MCID: CLS010
MIFTS: 50

Cluster Headache malady

Rare diseases, Neuronal diseases categories

Summaries for Cluster Headache

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NIH Rare Diseases:42 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.  a cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  in some individuals, it may be preceded by a migraine-like "aura." the pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. males are much more likely than females to develop cluster headaches.  last updated: 5/1/2008

MalaCards based summary: Cluster Headache is related to migraine and headache. An important gene associated with Cluster Headache is HCRTR2 (hypocretin (orexin) receptor 2), and among its related pathways are Adenylate cyclase activating neuropeptides and G alpha (s) signalling events. The drugs cyproheptadine and dihydroergotamine and the compounds triptan and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related mouse phenotypes are immune system and behavior/neurological.

Wikipedia:64 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Aliases & Classifications for Cluster Headache

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS, 26ICD10
See all sources

Cluster Headache, Aliases & Descriptions:

Name: Cluster Headache 42 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

ICD1026 G44.0

Related Diseases for Cluster Headache

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Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to cluster headache

Symptoms for Cluster Headache

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Drugs & Therapeutics for Cluster Headache

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Genetic Tests for Cluster Headache

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Anatomical Context for Cluster Headache

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MalaCards organs/tissues related to Cluster Headache:

32
Eye, Brain, Hypothalamus, Testes, Spinal cord, Heart, Pineal, Pituitary, Lung, Neutrophil

Animal Models for Cluster Headache or affiliated genes

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MGI Mouse Phenotypes related to Cluster Headache:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0CACNA1A, HP, HTR3A, VIP
2MP:00053867.6CALCA, CACNA1A, HTR3A, VIP, HCRTR2
3MP:00053767.4VIP, HTR3A, HP, CACNA1A, CALCA
4MP:00107687.2VIP, HTR3A, HP, CACNA1A, CALCA

Publications for Cluster Headache

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Articles related to Cluster Headache:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Study of cluster headache: A hospital-based study. (25288839)
2014
2
Corticosteroids alter CGRP and melatonin release in cluster headache episodes. (24958681)
2014
3
Lateralized nociceptive blink reflex habituation deficit in episodic cluster headache: Correlations with clinical features. (25228682)
2014
4
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
5
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
6
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
7
Cluster headache: what has changed since 1999? (23695050)
2013
8
Changes in Plasma Methionine-Enkephalin Levels Associated With a Cluster Headache Episode. (23353772)
2013
9
Cluster headache associated with acute maxillary sinusitis. (24133652)
2013
10
Cluster headache and arachnoid cyst. (23419954)
2013
11
Use of cannabis among 139 cluster headache sufferers. (23197349)
2013
12
Cluster headache and sleep, is there a connection? A review. (22407656)
2012
13
Female cluster headache in the United States of America: what are the gender differences? Results from the United States Cluster Headache Survey. (22482825)
2012
14
A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache. (22581595)
2012
15
Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. (21848953)
2011
16
Peripheral neurostimulation for the treatment of refractory cluster headache, long-term follow-up: case report. (21854497)
2011
17
Acute and preventive pharmacologic treatment of cluster headache. (21980606)
2011
18
Needle-free subcutaneous sumatriptan: in the acute treatment of migraine attacks or cluster headache episodes. (22054121)
2011
19
Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. (21349186)
2011
20
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
21
Secondary chronic cluster headache due to trigeminal nerve root compression. (20384588)
2010
22
Allodynia in cluster headache. (20425203)
2010
23
Can response to indomethacin exclude the diagnosis of cluster headache? (20656700)
2010
24
Role of sphenopalatine ganglion neuroablation in the management of cluster headache. (20425206)
2010
25
Oxygen treatment in acute cluster headache. (19272273)
2009
26
Genetic aspects of cluster headache. (19271945)
2009
27
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
28
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
29
Cluster headache, hypothalamus, and orexin. (19272281)
2009
30
Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. (19330286)
2009
31
Use of complementary and alternative medicine by patients with cluster headache: results of a multi-centre headache clinic survey. (18638713)
2008
32
Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache. (18547217)
2008
33
Reduced habituation of trigeminal reflexes in patients with episodic cluster headache during cluster period. (18624808)
2008
34
Internal carotid artery dissection presenting as cluster headache. (18949282)
2008
35
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
36
The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. (17539953)
2007
37
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
38
Using ice cream headache to help physicians experience the pain of and empathize with cluster headache patients. (16288968)
2006
39
Cluster headache due to internal carotid artery dissection. (16541217)
2006
40
Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache. (16885751)
2006
41
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
42
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
43
Decreasing incidence of cluster headache: a population-based study in Olmsted County, Minnesota. (15836596)
2005
44
Cluster headache from the patient's point of view. (15745622)
2005
45
Cluster headache: diagnosis and treatment. (15745625)
2005
46
Cluster headache with obstructive sleep apnea and periodic limb movements during sleep: a case report. (15663620)
2005
47
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
48
Subcutaneous sumatriptan induces changes in frequency pattern in cluster headache patients. (15209695)
2004
49
Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. (7516861)
1994
50
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991

Variations for Cluster Headache

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Expression for genes affiliated with Cluster Headache

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Expression patterns in normal tissues for genes affiliated with Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for genes affiliated with Cluster Headache

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Pathways related to Cluster Headache according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CALCA, HCRTR2
29.2CALCA, VIP

Compounds for genes affiliated with Cluster Headache

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Compounds related to Cluster Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1triptan449.8HTR3A, CALCA
2hydroxyproline44 25 1211.8HP, CALCA
3helospectin449.6CALCA, VIP
4cromakalim44 2910.6VIP, CALCA
5hexamethonium44 2910.6VIP, CALCA
6guanethidine44 1210.6CALCA, VIP
7sodium fluoride449.6VIP, CALCA
8mibg449.6VIP, CALCA
9thiorphan44 29 1211.6VIP, CALCA
10n(g)-nitro-l-arginine methyl ester449.6VIP, CALCA
11ng-nitro-l-arginine449.6CALCA, VIP
12phosphoramidon44 1210.6CALCA, VIP
13nitroglycerin44 1210.6CALCA, VIP
14captopril44 60 50 29 1213.5CALCA, VIP
15methacholine44 50 1211.5VIP, CALCA
16glibenclamide44 29 50 6012.5CALCA, VIP
17anaphylatoxin449.5HP, VIP
18capsaicin44 2910.5VIP, CALCA
19octreotide44 60 29 1212.5CALCA, VIP
20prostaglandin f2alpha449.5CALCA, VIP
21atropine44 29 1211.5VIP, CALCA
225-hydroxyindoleacetic acid44 2510.4HTR3A, VIP
23corticosterone44 60 2511.4CALCA, VIP
24polyethylene glycol449.3HP, VIP
25melatonin44 29 60 25 1213.3VIP, HTR3A
26catecholamine449.2VIP, HCRTR2
27gp 130449.2HP, VIP
28verapamil44 29 50 25 1213.1CACNA1A, VIP
29thyroxine44 2510.1CALCA, HP, VIP
30haloperidol44 50 29 3 1213.1HTR3A, VIP
31epinephrine44 25 1211.1CALCA, VIP, HP
32cyclosporin a44 29 6011.0HP, VIP, CALCA
33pge2449.0CALCA, VIP, HP
34sumatriptan44 29 60 50 25 1214.0CALCA, HTR3A, VIP
35lactate449.0CALCA, HP, VIP
36tetrodotoxin44 60 2911.0CALCA, HTR3A, VIP
37propranolol44 29 50 25 1213.0CALCA, VIP, HTR3A
385-hydroxytryptamine449.0HTR3A, CALCA, VIP
39testosterone44 60 25 1211.9VIP, HP, CALCA
40dopamine44 29 25 1211.9HTR3A, VIP, CALCA
41acth448.7HP, CALCA, VIP, HCRTR2
42dexamethasone44 50 29 1211.7VIP, HP, HTR3A
43norepinephrine44 25 1210.6CALCA, HTR3A, VIP, HCRTR2
44histamine44 29 2510.6CALCA, HTR3A, VIP, HCRTR2
45vegf448.6HP, VIP, CALCA
46glutamate448.6CALCA, VIP, HP, CACNA1A
47adenylate448.5VIP, HP, CALCA, HTR3A
48nitric oxide44 25 1210.4VIP, CALCA, HP
49calcium44 50 25 1211.1CACNA1A, CALCA, HP, VIP, HCRTR2
50acetylcholine44 50 29 25 1212.1HCRTR2, HTR3A, VIP, CACNA1A, CALCA

GO Terms for genes affiliated with Cluster Headache

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Cellular components related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.1CALCA, CACNA1A, HTR3A, VIP

Biological processes related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:0076319.6CALCA, HCRTR2
2positive regulation of cytosolic calcium ion concentrationGO:0072049.5CALCA, CACNA1A
3neuropeptide signaling pathwayGO:0072189.3CALCA, HCRTR2
4positive regulation of vasodilationGO:0459099.3CALCA, VIP
5synaptic transmissionGO:0072688.8HCRTR2, HTR3A, CACNA1A

Molecular functions related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.2CALCA, VIP

Products for genes affiliated with Cluster Headache

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Sources for Cluster Headache

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet