MCID: CLS010
MIFTS: 51

Cluster Headache malady

Neuronal category

Summaries for Cluster Headache

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.  a cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  in some individuals, it may be preceded by a migraine-like "aura." the pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. males are much more likely than females to develop cluster headaches.  last updated: 5/1/2008

MalaCards: Cluster Headache is related to sleep disorder and acute myocardial infarction. An important gene associated with Cluster Headache is HCRTR2 (hypocretin (orexin) receptor 2), and among its related pathways are Phenylalanine metabolism and Cytochrome P450 - arranged by substrate type. The drugs cyproheptadine and dihydroergotamine and the compounds estrogen and triptan have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:64 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Aliases & Classifications for Cluster Headache

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

cluster headache 43 45 61


External Ids:

ICD1025 G44.0

Related Diseases for Cluster Headache

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to cluster headache

Clinical Features for Cluster Headache

Drugs & Therapeutics for Cluster Headache

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cluster Headache

Drug clinical trials:

Search ClinicalTrials for Cluster Headache

Search NIH Clinical Center for Cluster Headache

Search CenterWatch for Cluster Headache

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cluster Headache

Anatomical Context for Cluster Headache

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cluster Headache:

33
Brain, Spinal cord, Heart, Lung, T cells, Hypothalamus, Trigeminal ganglion, Pineal, Pituitary

Animal Models for Cluster Headache or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cluster Headache:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0CALCA, CACNA1A, HTR3A, NPY, AKR1A1, HFE
2MP:00053868.4ADH7, VIP, CALCA, CACNA1A, HTR1B, HTR3A

Publications for Cluster Headache

Sources:
51PubMed
See all sources

Articles related to Cluster Headache:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Cluster headache and arachnoid cyst. (23419954)
2013
2
Secondary chronic cluster headache treated by posterior hypothalamic deep brain stimulation: first reported case. (23165695)
2013
3
Brainstem activation in cluster headache: an adaptive behavioural response? (23359873)
2013
4
Deep Brain Stimulation of the Posterior Hypothalamus for Cluster Headache-How High Should the Threshold Be? (23500341)
2013
5
Cluster headache - a symptom of different problems or a primary form? A case report. (23650009)
2013
6
The psychiatric comorbidities of cluster headache. (23296640)
2013
7
Differences in clinical characteristics and frequency of accompanying migraine features in episodic and chronic cluster headache. (22529192)
2012
8
Traumatic head injury in cluster headache: cause or effect? (22274664)
2012
9
A patient with cluster headache--due to a brainstem lesion. (22077341)
2012
10
Efficacy of hypothalamic stimulation for chronic drug-resistant cluster headache. (22259048)
2012
11
White blood cell SPECT during active period of cluster headache and in remission. (21771198)
2012
12
Acute and preventive pharmacologic treatment of cluster headache. (21980606)
2011
13
Mere surgery will not cure cluster headache--implications for neurostimulation. (20974592)
2011
14
A probable cluster headache case from a textbook of 1726: Francisco Suarez de Rivera's description. (21768182)
2011
15
Frovatriptan for prophylactic treatment of cluster headache. (21453330)
2011
16
Cluster headache and oxygen: is it possible to predict which patients will be relieved? A retrospective cross-sectional correlation study. (20422207)
2010
17
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
18
Chronic cluster-like headache secondary to prolactinoma: uncommon cephalalgia in association with brain tumors. (18694630)
2009
19
Cranial autonomic symptoms in migraine: characteristics and comparison with cluster headache. (18931007)
2009
20
Cluster headache: pharmacological treatment and neurostimulation. (19262591)
2009
21
Endocrinology of cluster headache: potential for therapeutic manipulation. (18474195)
2008
22
Investigation of the T3111C CLOCK gene polymorphism in cluster headache. (18283403)
2008
23
The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. (18789357)
2008
24
Normobaric and hyperbaric oxygen therapy for migraine and cluster headache. (18646121)
2008
25
High cervical epidural neurostimulation for cluster headache: case report and review of the literature. (18727646)
2008
26
Cluster headache triggered by high-dose gestagens in the context of in vitro fertilization: a case report. (17850352)
2007
27
Nocturnal secretion of growth hormone, noradrenaline, cortisol and insulin in cluster headache remission. (17645758)
2007
28
Effect on sleep of posterior hypothalamus stimulation in cluster headache. (17635601)
2007
29
Cluster headache attacks in a woman previously struck by lightning: pathophysiology of the latent period. (17607444)
2007
30
Supraorbital nerve electric stimulation for the treatment of intractable chronic cluster headache: a case report. (17635606)
2007
31
Hypothalamic stimulation for intractable cluster headache: long-term experience. (16832097)
2006
32
Diagnosis and treatment of cluster headache. (16628535)
2006
33
Should cluster headache be associated with cutaneous allodynia? (16919053)
2006
34
Impaired thermal perception in cluster headache. (16649093)
2006
35
Lifetime prevalence and concordance risk of cluster headache in the Swedish twin population. (16966540)
2006
36
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
37
Cluster headache: diagnosis and treatment. (15745625)
2005
38
Change in frequency pattern in cluster headache induced by subcutaneous sumatriptan. (16109129)
2005
39
History of cluster headache. (15745624)
2005
40
Circulating nociceptin levels during the cluster headache period. (15030536)
2004
41
High oxygen flow rates for cluster headache. (15304611)
2004
42
Remission of refractory chronic cluster headache after warfarin administrations: case report. (15608975)
2004
43
Complete but transient relief of chronic cluster headache with mycophenolate mofetil. (15330831)
2004
44
Symptomatic cluster headache in internal carotid artery dissection--consider anhidrosis. (12940812)
2003
45
Clusterlike headache as first manifestation of a prolactinoma. (11554962)
2001
46
Cognitive processing is involved in cluster headache but not in chronic paroxysmal hemicrania. (10430426)
1999
47
Cluster headache management with methylphenidate (Ritalin). (15613186)
1998
48
Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. (7516861)
1994
49
Neuropeptides in migraine and cluster headache. (7828188)
1994
50
Cluster headache after herpes zoster ophthalmicus. (7092621)
1982

Genetic Variations for Cluster Headache

Expression for genes affiliated with Cluster Headache

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for genes affiliated with Cluster Headache

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Cluster Headache according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ADH7, ADH4
2
Hide members
10.2ADH7, ADH4
3
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10.0HTR1B, HTR3A, HTR1D
4
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10.0ADH7, AKR1A1, ADH4
5
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10.0ADH7, ADH4, AKR1A1
6
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9.7HTR1D, HTR3A, HTR1B, GNB3, CACNA1A
7
Hide members
9.6CACNA1A, CLOCK, HTR1D, HTR3A, HTR1B, GNB3
8
Hide members
9.4PNOC, HCRTR2, NPY, HTR1D, HTR1B, GNB3
9
Hide members
9.3VIP, GNB3, HTR1B, HTR1D, NPY, HCRTR2

Compounds for genes affiliated with Cluster Headache

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 2BitterDB, 50PharmGKB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Cluster Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6PNOC
2triptan4510.5CALCA, HTR3A, HTR1B
3helospectin4510.5VIP, CALCA, NPY
4frovatriptan45 1111.4HTR1B, HTR3A, HTR1D
5cyanopindolol45 2911.4HTR3A, HTR1B, HTR1D
6rizatriptan45 29 1112.4HTR1D, CALCA, HTR1B
7hexamethonium45 2911.4PNOC, CALCA, VIP
8ru 2496929 4511.4HTR1D, HTR3A, HTR1B
92-methyl-5-ht45 2911.4HTR1B, HTR3A, HTR1D
10ipsapirone45 2911.4HTR1B, HTR1D, HTR3A
115-carboxamidotryptamine4510.4HTR3A, HTR1D, HTR1B
12almotriptan45 1111.4HTR1B, HTR1D, HTR3A
13dihydroergotamine29 45 1112.4HTR1B, HTR3A, HTR1D
14zotepine45 2911.3HTR1B, HTR1D, HTR3A
15methiothepin45 2911.3HTR1B, HTR1D, HTR3A
16atropine45 29 1112.3NPY, CALCA, PNOC
17guanethidine45 1111.3PNOC, NPY, CALCA, VIP
18ritanserin29 4511.3HTR3A, HTR1D, HTR1B
19metergoline45 2911.3HTR1B, HTR3A, HTR1D
20methysergide45 29 1112.2HTR1B, HTR1D, HTR3A
21yohimbine45 29 2 1113.2HTR3A, HTR1B, NPY, HTR1D
22acetylcholine45 50 29 11 2414.2CALCA, CACNA1A, HTR3A, HCRTR2, PNOC
23tryptamine45 29 2412.2HTR1B, HTR3A, HTR1D
24tetrodotoxin45 60 2912.2NPY, VIP, CALCA, HTR3A
25melatonin45 60 29 11 2414.2HTR3A, CLOCK, IL2RB
26olanzapine50 45 29 11 2414.2HTR1B, HTR1D, GNB3, HTR3A
27propranolol45 29 50 11 2414.2HTR3A, HTR1B, CALCA, VIP, HTR1D
28fenfluramine29 45 1112.1HTR3A, NPY, HTR1B
29thyroxine45 2411.1NPY, HP, IL2RB, CALCA, VIP
30capsaicin45 2911.1CALCA, NPY, S100A12, VIP, PNOC
31ergotamine29 45 1112.1HTR1D, HTR3A, HTR1B
32sumatriptan45 29 60 50 11 2415.1CALCA, VIP, GNB3, HTR1B, HTR3A, HTR1D
33ketanserin29 4511.0HTR1B, HTR3A, HTR1D
34vitamin a45 11 2411.9ADH7, ADH4, AKR1A1, SERPINA1, HP
35acth459.9VIP, CALCA, HCRTR2, NPY, SERPINA1, IL2RB
36ethanol45 50 11 2412.9ADH4, SERPINA1, HP, AKR1A1, ADH7, HFE
37haloperidol45 29 2 50 1113.9NPY, AKR1A1, VIP, HTR1D, IL2RB, HTR3A
38clozapine45 29 50 1112.9HTR1D, HTR3A, HTR1B, GNB3
39gaba459.8PNOC, HTR3A, NPY, VIP, AKR1A1
40lactate459.8CALCA, NPY, AKR1A1, HP, VIP, IL2RB
41cyclic amp45 2410.7IL2RB, NPY, PNOC, HTR1B, HTR1D, VIP
42dopamine45 29 11 2412.7HTR3A, HTR1D, NPY, AKR1A1, CLOCK, PNOC
43histamine45 29 2411.7HTR3A, PNOC, IL2RB, HCRTR2, AKR1A1, NPY
44epinephrine45 11 2411.7CALCA, VIP, HP, NPY, GNB3
455-hydroxytryptamine459.6HTR1D, VIP, CALCA, HTR1B, HTR3A, PNOC
46adenylate459.6CALCA, HTR3A, HTR1D, NPY, AKR1A1, HP
47alanine459.6PNOC, HFE, AKR1A1, VIP, HCRTR2, HP
48norepinephrine45 11 2411.6CALCA, HTR3A, PNOC, IL2RB, HCRTR2, NPY
49nitric oxide45 11 2411.5GNB3, CALCA, IL2RB, HTR1B, HP, PNOC
50creatinine459.2HP, SERPINA1, AKR1A1, CALCA, IL2RB, NPY

GO Terms for genes affiliated with Cluster Headache

Sources:
16Gene Ontology
See all sources

Cellular components related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.9VIP, CALCA, CACNA1A, HTR3A
2integral to plasma membraneGO:0058879.6HTR3A, HTR1D, HFE, HCRTR2, IL2RB, HTR1B
3extracellular regionGO:0055769.2ADH7, VIP, CALCA, S100A12, NPY, HP
4plasma membraneGO:0058868.6CACNA1A, S100A12, GNB3, HTR1B, HTR3A, HTR1D

Biological processes related to Cluster Headache according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor internalizationGO:00203110.3HTR1B, CALCA
2feeding behaviorGO:00763110.3CALCA, NPY, HCRTR2
3regulation of behaviorGO:05079510.3HTR1D, HTR1B
4ethanol oxidationGO:00606910.3ADH7, ADH4
5regulation of blood pressureGO:00821710.2NPY, GNB3, CALCA
6monocyte chemotaxisGO:00254810.2S100A12, CALCA
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.2HTR1B, HTR1D, NPY
8cellular aldehyde metabolic processGO:00608110.1AKR1A1, ADH4
9neuropeptide signaling pathwayGO:00721810.1PNOC, CALCA, HCRTR2, NPY
10defense response to bacteriumGO:0427429.8S100A12, ANXA3, HP
11vasoconstrictionGO:0423109.8HTR1B, HTR1D
12synaptic transmissionGO:0072689.5HTR1D, HTR1B, HTR3A, CACNA1A, NPY, HCRTR2

Molecular functions related to Cluster Headache according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:00402410.3ADH4, ADH7
2retinol dehydrogenase activityGO:00474510.2ADH7, ADH4
3serotonin bindingGO:05137810.2HTR1D, HTR3A, HTR1B
4neuropeptide hormone activityGO:00518410.1VIP, NPY, PNOC
5serotonin receptor activityGO:00499310.1HTR1D, HTR3A, HTR1B
6alditol:NADP+ 1-oxidoreductase activityGO:00403210.1ADH4, AKR1A1
7alcohol dehydrogenase (NAD) activityGO:00402210.1ADH7, ADH4
8retinol bindingGO:0198419.9ADH7, ADH4

Products for genes affiliated with Cluster Headache

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  • Lysates
  • Antibodies

Sources for Cluster Headache

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet