MCID: CLS010
MIFTS: 43

Cluster Headache malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Cluster Headache

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS, 25ICD10
See all sources

Cluster Headache, Aliases & Descriptions:

Name: Cluster Headache 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

ICD1025 G44.0

Summaries for Cluster Headache

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NIH Rare Diseases:41 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.  a cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  in some individuals, it may be preceded by a migraine-like "aura." the pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. males are much more likely than females to develop cluster headaches.  last updated: 5/1/2008

MalaCards based summary: Cluster Headache is related to migraine and headache. An important gene associated with Cluster Headache is HCRTR2 (hypocretin (orexin) receptor 2), and among its related pathways are Adenylate cyclase activating neuropeptides and G alpha (s) signalling events. The drugs cyproheptadine and dihydroergotamine and the compounds triptan and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related mouse phenotypes are immune system and behavior/neurological.

Wikipedia:63 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Related Diseases for Cluster Headache

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Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to cluster headache

Symptoms for Cluster Headache

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Drugs & Therapeutics for Cluster Headache

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Genetic Tests for Cluster Headache

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Anatomical Context for Cluster Headache

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MalaCards organs/tissues related to Cluster Headache:

31
Eye, Brain, Hypothalamus, Testes, Spinal cord, Pituitary, Heart, Pineal, Lung, Neutrophil

Animal Models for Cluster Headache or affiliated genes

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MGI Mouse Phenotypes related to Cluster Headache:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0CACNA1A, HP, HTR3A, VIP
2MP:00053867.6CALCA, CACNA1A, HTR3A, VIP, HCRTR2
3MP:00053767.4VIP, HTR3A, HP, CACNA1A, CALCA
4MP:00107687.2VIP, HTR3A, HP, CACNA1A, CALCA

Publications for Cluster Headache

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Articles related to Cluster Headache:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Abnormal coactivation of the hypothalamus and salience network in patients with cluster headache. (25746559)
2015
2
Value of intra- and post-operative cone beam computed tomography (CBCT) for positioning control of a sphenopalatine ganglion neurostimulator in patients with chronic cluster headache. (25648069)
2015
3
Study of cluster headache: A hospital-based study. (25288839)
2014
4
Corticosteroids alter CGRP and melatonin release in cluster headache episodes. (24958681)
2014
5
Lateralized nociceptive blink reflex habituation deficit in episodic cluster headache: Correlations with clinical features. (25228682)
2014
6
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
7
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
8
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
9
Cluster headache: what has changed since 1999? (23695050)
2013
10
Changes in Plasma Methionine-Enkephalin Levels Associated With a Cluster Headache Episode. (23353772)
2013
11
Cluster headache associated with acute maxillary sinusitis. (24133652)
2013
12
Cluster headache and arachnoid cyst. (23419954)
2013
13
Use of cannabis among 139 cluster headache sufferers. (23197349)
2013
14
Cluster headache and sleep, is there a connection? A review. (22407656)
2012
15
A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache. (22581595)
2012
16
Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: Experience in five patients with a modified anatomical target. (22116943)
2011
17
Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. (21848953)
2011
18
Peripheral neurostimulation for the treatment of refractory cluster headache, long-term follow-up: case report. (21854497)
2011
19
Needle-free subcutaneous sumatriptan: in the acute treatment of migraine attacks or cluster headache episodes. (22054121)
2011
20
Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. (21349186)
2011
21
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
22
Secondary chronic cluster headache due to trigeminal nerve root compression. (20384588)
2010
23
Allodynia in cluster headache. (20425203)
2010
24
Can response to indomethacin exclude the diagnosis of cluster headache? (20656700)
2010
25
Role of sphenopalatine ganglion neuroablation in the management of cluster headache. (20425206)
2010
26
Oxygen treatment in acute cluster headache. (19272273)
2009
27
Genetic aspects of cluster headache. (19271945)
2009
28
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
29
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
30
Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. (19330286)
2009
31
Use of complementary and alternative medicine by patients with cluster headache: results of a multi-centre headache clinic survey. (18638713)
2008
32
Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache. (18547217)
2008
33
Reduced habituation of trigeminal reflexes in patients with episodic cluster headache during cluster period. (18624808)
2008
34
Internal carotid artery dissection presenting as cluster headache. (18949282)
2008
35
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
36
The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. (17539953)
2007
37
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
38
Using ice cream headache to help physicians experience the pain of and empathize with cluster headache patients. (16288968)
2006
39
Cluster headache due to internal carotid artery dissection. (16541217)
2006
40
Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache. (16885751)
2006
41
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
42
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
43
Decreasing incidence of cluster headache: a population-based study in Olmsted County, Minnesota. (15836596)
2005
44
Cluster headache from the patient's point of view. (15745622)
2005
45
Cluster headache: diagnosis and treatment. (15745625)
2005
46
Cluster headache with obstructive sleep apnea and periodic limb movements during sleep: a case report. (15663620)
2005
47
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
48
Subcutaneous sumatriptan induces changes in frequency pattern in cluster headache patients. (15209695)
2004
49
Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. (7516861)
1994
50
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991

Variations for Cluster Headache

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Expression for genes affiliated with Cluster Headache

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Search GEO for disease gene expression data for Cluster Headache.

Pathways for genes affiliated with Cluster Headache

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Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CALCA, VIP

Compounds for genes affiliated with Cluster Headache

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Compounds related to Cluster Headache according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1triptan439.8CALCA, HTR3A
2hydroxyproline43 24 1211.8CALCA, HP
3helospectin439.6VIP, CALCA
4cromakalim43 2810.6VIP, CALCA
5hexamethonium43 2810.6VIP, CALCA
6guanethidine43 1210.6VIP, CALCA
7sodium fluoride439.6CALCA, VIP
8mibg439.6CALCA, VIP
9thiorphan43 28 1211.6CALCA, VIP
10n(g)-nitro-l-arginine methyl ester439.6VIP, CALCA
11ng-nitro-l-arginine439.6CALCA, VIP
12phosphoramidon43 1210.6CALCA, VIP
13nitroglycerin43 1210.6VIP, CALCA
14captopril43 59 49 28 1213.5CALCA, VIP
15methacholine43 49 1211.5VIP, CALCA
16glibenclamide43 28 49 5912.5CALCA, VIP
17anaphylatoxin439.5HP, VIP
18capsaicin43 2810.5CALCA, VIP
19octreotide43 59 28 1212.5VIP, CALCA
20prostaglandin f2alpha439.5CALCA, VIP
21atropine43 28 1211.5CALCA, VIP
225-hydroxyindoleacetic acid43 2410.4VIP, HTR3A
23corticosterone43 59 2411.4CALCA, VIP
24polyethylene glycol439.3HP, VIP
25melatonin43 28 59 24 1213.3HTR3A, VIP
26catecholamine439.2VIP, HCRTR2
27gp 130439.2HP, VIP
28verapamil43 28 49 24 1213.1CACNA1A, VIP
29thyroxine43 2410.1VIP, HP, CALCA
30haloperidol43 49 28 2 1213.1HTR3A, VIP
31epinephrine43 24 1211.1CALCA, HP, VIP
32cyclosporin a43 28 5911.0CALCA, HP, VIP
33pge2439.0CALCA, HP, VIP
34sumatriptan43 28 59 49 24 1214.0VIP, HTR3A, CALCA
35lactate439.0VIP, HP, CALCA
36tetrodotoxin43 59 2811.0CALCA, HTR3A, VIP
37propranolol43 28 49 24 1213.0VIP, HTR3A, CALCA
385-hydroxytryptamine439.0CALCA, HTR3A, VIP
39testosterone43 59 24 1211.9VIP, HP, CALCA
40dopamine43 28 24 1211.9CALCA, HTR3A, VIP
41acth438.7HCRTR2, VIP, HP, CALCA
42dexamethasone43 49 28 1211.7VIP, HTR3A, HP
43norepinephrine43 24 1210.6CALCA, HTR3A, VIP, HCRTR2
44histamine43 28 2410.6HCRTR2, VIP, HTR3A, CALCA
45vegf438.6VIP, HP, CALCA
46glutamate438.6VIP, HP, CACNA1A, CALCA
47adenylate438.5CALCA, HP, HTR3A, VIP
48nitric oxide43 24 1210.4CALCA, HP, VIP
49calcium43 49 24 1211.1HCRTR2, VIP, HP, CACNA1A, CALCA
50acetylcholine43 49 28 24 1212.1CALCA, CACNA1A, HTR3A, VIP, HCRTR2

GO Terms for genes affiliated with Cluster Headache

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Cellular components related to Cluster Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.1CALCA, CACNA1A, HTR3A, VIP

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00076319.6CALCA, HCRTR2
2positive regulation of cytosolic calcium ion concentrationGO:00072049.5CALCA, CACNA1A
3neuropeptide signaling pathwayGO:00072189.3CALCA, HCRTR2
4positive regulation of vasodilationGO:00459099.3CALCA, VIP
5synaptic transmissionGO:00072688.8HCRTR2, HTR3A, CACNA1A

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.2CALCA, VIP

Products for genes affiliated with Cluster Headache

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Sources for Cluster Headache

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet