MCID: CLS010
MIFTS: 47

Cluster Headache

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Cluster Headache

MalaCards integrated aliases for Cluster Headache:

Name: Cluster Headache 49 36 51 69

Classifications:



External Ids:

KEGG 36 H01588
ICD10 32 G44.0
UMLS 69 C0009088

Summaries for Cluster Headache

NIH Rare Diseases : 49 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks. The headaches are accompanied by autonomic symptoms, and some people experience restlessness and agitation. A cluster headache begins with severe pain strictly on one side of the head, often behind or around one eye. In some people, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to three hours before going away. Typical attacks may strike up to eight times a day and are relatively short-lived. On average, a cluster period lasts 6 to 12 weeks. Autonomic symptoms may include: conjunctival injection (bloodshot eyes), swelling under or around the eye, excessive tearing of the eyes, drooping of the eyelid, runny nose and/or nasal congestion, and forehead and facial sweating. These symptoms generally occur only during the pain attack and are on the same side as the headache pain. Cluster headaches usually begin between the ages of 20 and 50, although they can start at any age. Males are more commonly affected than females. Treatment can be divided into acute therapy aimed at stopping symptoms once they have started and preventive therapy aimed at preventing recurrent attacks during the cluster period. Last updated: 7/14/2015

MalaCards based summary : Cluster Headache is related to headache and migraine with or without aura 1, and has symptoms including recurrent paroxysmal headache and headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways are Circadian entrainment and Myometrial Relaxation and Contraction Pathways. The drugs Sumatriptan and Rizatriptan have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 72 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Related Diseases for Cluster Headache

Diseases in the Cluster Headache family:

Cluster Headache, Familial

Diseases related to Cluster Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 headache 32.5 CACNA1A CALCA
2 migraine with or without aura 1 29.8 CACNA1A CALCA HCRT VIP
3 sleep disorder 29.4 HCRT HCRTR2
4 restless legs syndrome 28.1 CACNA1A CLOCK HCRT NOS1
5 cluster headache, familial 12.3
6 paroxysmal hemicrania 11.5
7 hemicrania continua 10.7
8 episodic pain syndrome, familial, 1 10.3
9 familial hemiplegic migraine 10.2 CACNA1A CALCA
10 wdha syndrome 10.2 CALCA VIP
11 leprosy 2 10.2 CALCA VIP
12 vasomotor rhinitis 10.2 CALCA VIP
13 hemiplegic migraine 10.2 CACNA1A CALCA
14 vipoma 10.1 CALCA VIP
15 pancreatic cholera 10.1 CALCA VIP
16 somatostatinoma 10.1 CALCA VIP
17 rohhad 10.1 HCRT HCRTR2
18 diffuse pulmonary fibrosis 10.1 CALCA VIP
19 islet cell tumor 10.1 CALCA VIP
20 hemiplegia 10.1 CACNA1A CALCA
21 carotid artery dissection 10.0
22 alternating hemiplegia of childhood 10.0 CACNA1A CALCA
23 sleep apnea 10.0
24 cervicitis 10.0
25 apnea, obstructive sleep 9.9
26 cerebritis 9.9
27 advanced sleep phase syndrome 9.9 CLOCK HCRT
28 horner's syndrome 9.9
29 urticaria pigmentosa 9.8 CALCA IL2RA VIP
30 multiple sclerosis 9.8
31 aging 9.8
32 cataract 9.8
33 sinusitis 9.8
34 migraine with aura 9.8
35 migraine without aura 9.8
36 acute maxillary sinusitis 9.8
37 maxillary sinusitis 9.8
38 retinitis 9.8
39 meningitis 9.8
40 glioblastoma 9.8
41 harlequin syndrome 9.8
42 aneurysm 9.8
43 head injury 9.8
44 hemifacial spasm 9.8
45 achalasia 9.7 NOS1 VIP
46 narcolepsy 9.7 CLOCK HCRT HCRTR2
47 endocrine gland cancer 9.7 CALCA VIP
48 glioma susceptibility 1 9.6
49 parkinson disease, late-onset 9.6
50 thrombophilia due to thrombin defect 9.6

Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to Cluster Headache

Symptoms & Phenotypes for Cluster Headache

UMLS symptoms related to Cluster Headache:


recurrent paroxysmal headache, headache

MGI Mouse Phenotypes related to Cluster Headache:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 CACNA1A CLOCK HCRT HCRTR2 NOS1 VIP
2 endocrine/exocrine gland MP:0005379 9.35 CACNA1A CLOCK IL2RA NOS1 VIP
3 respiratory system MP:0005388 9.02 IL2RA NOS1 VIP CACNA1A HCRT

Drugs & Therapeutics for Cluster Headache

Drugs for Cluster Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sumatriptan Approved, Investigational Phase 4,Phase 3 103628-46-2 5358
2
Rizatriptan Approved Phase 4 144034-80-0, 145202-66-0 5078
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Bupivacaine Approved, Investigational Phase 4,Early Phase 1 38396-39-3, 2180-92-9 2474
5
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
6
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
7
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 60857 441240
8
Topiramate Approved Phase 4 97240-79-4 5284627
9
Serotonin Phase 4,Phase 3 50-67-9 5202
10 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
11 Serotonin 5-HT1 Receptor Agonists Phase 4,Phase 3
12 Serotonin Agents Phase 4,Phase 3
13 Gastrointestinal Agents Phase 4,Phase 1,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
16 Anesthetics Phase 4,Phase 3,Phase 2,Early Phase 1
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
18 Antiemetics Phase 4,Phase 1,Phase 2
19 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
20 Autonomic Agents Phase 4,Phase 1,Phase 2
21
protease inhibitors Phase 4,Phase 2
22 HIV Protease Inhibitors Phase 4,Phase 2
23 Anesthetics, Local Phase 4,Phase 2,Early Phase 1
24 Anticonvulsants Phase 4
25 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
26 triamcinolone acetonide Phase 4
27 Dexamethasone acetate Phase 4 1177-87-3
28 glucocorticoids Phase 4
29 Triamcinolone diacetate Phase 4
30 Triamcinolone hexacetonide Phase 4
31 Hormone Antagonists Phase 4,Phase 2
32 Hormones Phase 4,Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
34 Immunosuppressive Agents Phase 4
35 BB 1101 Phase 4
36 Respiratory System Agents Phase 4
37 Anti-Asthmatic Agents Phase 4
38 Betamethasone Valerate Phase 4 2152-44-5
39 Oxazolidinones Phase 4
40 Anti-Infective Agents Phase 4
41 Betamethasone benzoate Phase 4
42 Betamethasone sodium phosphate Phase 4
43 Betamethasone-17,21-dipropionate Phase 4
44 Neuroprotective Agents Phase 4
45 Protective Agents Phase 4
46 Anti-Obesity Agents Phase 4
47
Sodium oxybate Approved Phase 3 502-85-2 5360545
48
Verapamil Approved Phase 2, Phase 3 52-53-9 2520
49
Capsaicin Approved Phase 3 404-86-4 1548943
50 Cortivazol Investigational Phase 2, Phase 3 1110-40-3

Interventional clinical trials:

(show top 50) (show all 76)

# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 A Research Study to Examine Cutaneous Allodynia and Cluster Headache Completed NCT00329836 Phase 4
3 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo
4 A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks Recruiting NCT02655523 Phase 4 Triamcinolone;Dexamethasone;Normal Saline;Bupivacaine
5 Efficacy and Safety of Zolmitriptan by Sublingual Administration Not yet recruiting NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
6 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Not yet recruiting NCT02686983 Phase 4 Betamethasone and local anesthetic
7 A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Terminated NCT00203190 Phase 4 Topiramate
8 Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Unknown status NCT02637648 Phase 3 Sodium Oxybate;Placebo
9 Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache Completed NCT02462395 Phase 2, Phase 3
10 Cluster Headache Cortivazol Injection (CHCI) Completed NCT00804895 Phase 2, Phase 3 ALTIM, cortivazol injections;PROAMP, subcutaneous serum physiological saline;Verapamil
11 Intranasal Civamide for Episodic Cluster Headache Completed NCT00069082 Phase 3 Civamide (Zucapsaicin);Sodium Chloride
12 A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed NCT00033839 Phase 3 Civamide (Zucapsaicin)
13 Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Completed NCT00356603 Phase 3 Sumatriptan Succinate
14 A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) Recruiting NCT02964338 Phase 3 Fremanezumab- A;Fremanezumab- B;Placebo
15 Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache Recruiting NCT01151631 Phase 3
16 A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH) Recruiting NCT02945046 Phase 3 Fremanezumab - A;Fremanezumab - B;Placebo
17 A Study of LY2951742 in Participants With Episodic Cluster Headache Active, not recruiting NCT02397473 Phase 3 LY2951742;Placebo
18 A Study of LY2951742 in Participants With Chronic Cluster Headache Active, not recruiting NCT02438826 Phase 3 LY2951742;Placebo
19 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3 Galcanezumab
20 A Study to Explore the Long-Term Safety of TEV-48125 (Fremanezumab) for the Prevention of Cluster Headache Enrolling by invitation NCT03107052 Phase 3 Fremanezumab
21 Civamide Nasal Solution for Cluster Headache Not yet recruiting NCT01341548 Phase 3 Civamide nasal solution 0.01%
22 Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache Unknown status NCT00274170 Phase 1, Phase 2 Octreotide
23 Botox Injection in Treatment of Cluster Headache Completed NCT02019017 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 50 IU
24 Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care Completed NCT01701245 Phase 2
25 Prophylactic Treatment of Episodic Cluster Headache Completed NCT00184587 Phase 2 candesartan cilexetil;placebo
26 Occipital Nerve Stimulation to Treat Chronic Headaches Completed NCT00205894 Phase 1, Phase 2
27 Safety and Efficacy Study of SOM230 s.c. in Cluster Headache Recruiting NCT02619617 Phase 2 SOM230;Placebo
28 Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues Recruiting NCT03066635 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 12.5 IU
29 Psilocybin-facilitated Treatment for Cocaine Use Recruiting NCT02037126 Phase 2 Psilocybin;Diphenhydramine
30 R-Verapamil for the Prophylaxis of Episodic Cluster Headache Active, not recruiting NCT02209155 Phase 2 R-verapamil 75 mg tablet;Placebo
31 Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache Terminated NCT02381795 Phase 2 Nasal Carbon Dioxide
32 A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache Unknown status NCT01298921 Phase 1 Oxygen;Oxygen
33 Psilocybin for the Treatment of Cluster Headache Recruiting NCT02981173 Phase 1 0.143 mg/kg Psilocybin;0.0143 mg/kg Psilocybin;Placebo
34 Cluster Headache, Addictions and Vascular Function Unknown status NCT02640105
35 Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation Unknown status NCT02081482
36 Physiotherapy Program for Cluster Headache Unknown status NCT02460003
37 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570 Baclofen
38 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
39 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
40 Inflammatory Markers Identification in Migraine Patients Unknown status NCT01618201
41 Identification of Inflammatory Markers in Migraine Patients Unknown status NCT00969995
42 Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout Completed NCT03439722
43 Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study Completed NCT02853487
44 Sleep, Circadian Rhythms and Cluster Headache Completed NCT01447641
45 Cluster Headache and SPINK-1 Gene Completed NCT02585739
46 Intranasal Cooling for Cluster Headache and Migraine Completed NCT01898455
47 Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache Completed NCT01255813
48 Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache Completed NCT01792817
49 Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH) Completed NCT00662935
50 Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: a Prospective Case Series Completed NCT03244735

Search NIH Clinical Center for Cluster Headache

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Cluster Headache

Anatomical Context for Cluster Headache

MalaCards organs/tissues related to Cluster Headache:

38
Eye, Brain, Hypothalamus, Testes, Endothelial, Bone, Spinal Cord

Publications for Cluster Headache

Articles related to Cluster Headache:

(show top 50) (show all 698)
# Title Authors Year
1
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
2
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
3
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
4
Societal burden of cluster headache in the United States: a descriptive economic analysis. ( 29125368 )
2018
5
Systematic review of the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion for the treatment of refractory chronic cluster headache. ( 29338934 )
2018
6
Clinical Characteristics and Treatment Patterns Among Patients Diagnosed With Cluster Headache in U.S. Healthcare Claims Data. ( 28581025 )
2017
7
Ketamine Infusion Combined With Magnesium as a Therapy for Intractable Chronic Cluster Headache: Report of Two Cases. ( 28670718 )
2017
8
Economics of Inhaled Oxygen Use as an Acute Therapy for Cluster Headache in the United States of America. ( 28842974 )
2017
9
Oxygen for Cluster Headache. ( 28967120 )
2017
10
Treatment of intractable chronic cluster headache by occipital nerve stimulation: a cohort of 51 patients. ( 27995704 )
2017
11
Cluster headache and the trigeminal-autonomic reflex: Driving or being driven? ( 29082825 )
2017
12
Naratriptan in the Prophylactic Treatment of Cluster Headache. ( 28883254 )
2017
13
Improved surgical procedure using intraoperative navigation for the implantation of the SPG microstimulator in patients with chronic cluster headache. ( 28083804 )
2017
14
Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks. ( 29082823 )
2017
15
Cluster headache and middle meningeal artery dural arteriovenous fistulas: A case report. ( 29199428 )
2017
16
Carotid dissection presenting as a prolonged cluster-like headache in a patient with episodic cluster headache. ( 28765481 )
2017
17
Naratriptan May Become an Alternative Prophylactic Option for Patients with Cluster Headache. ( 28883259 )
2017
18
Identifying a gene expression signature of cluster headache in blood. ( 28074859 )
2017
19
Cost-effectiveness of gammaCore (non-invasive vagus nerve stimulation) for acute treatment of episodic cluster headache. ( 29144720 )
2017
20
The emerging role of gammaCoreAr in the management of cluster headache: expert panel recommendations. ( 29144718 )
2017
21
Cerebral hemodynamics in the different phases of migraine and cluster headache. ( 28857642 )
2017
22
Cluster headache: present and future therapy. ( 28527055 )
2017
23
Review of non-invasive vagus nerve stimulation (gammaCore): efficacy, safety, potential impact on comorbidities, and economic burden for episodic and chronic cluster headache. ( 29144717 )
2017
24
Personality disorders in cluster headache: a study using the Millon Clinical Multiaxial Inventory-III. ( 28527059 )
2017
25
Screening of genetic variants in ADCYAP1R1, MME and 14q21 in a Swedish cluster headache cohort. ( 28831700 )
2017
26
Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. ( 28856479 )
2017
27
The pathophysiology of episodic cluster headache: Insights from recent neuroimaging research. ( 28677993 )
2017
28
Pre-attack signs and symptoms in cluster headache: Characteristics and time profile. ( 28816505 )
2017
29
Calcitonin Gene-Related Peptide-Targeted Therapies for Migraine and Cluster Headache: A Review. ( 28644160 )
2017
30
Prescribing Oxygen for Cluster Headache: A Guide for the Provider. ( 28857152 )
2017
31
Cluster Headache Associated with Secondary Unilateral Blepharospasm: A Case Report and Review of the Literature. ( 28540017 )
2017
32
STN DBS for Advanced Parkinson Disease Simultaneously Alleviates Cluster Headache. ( 29422851 )
2017
33
Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks. ( 29082824 )
2017
34
Pathogenesis of chronic cluster headache and bouts: role of tryptamine, arginine metabolism and I+1-agonists. ( 28527056 )
2017
35
Non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A randomized, double-blind, sham-controlled ACT2 study. ( 29231763 )
2017
36
Clomiphene treatment may be effective in refractory episodic and chronic cluster headache. ( 28977141 )
2017
37
Neurovascular mechanisms of migraine and cluster headache. ( 28948863 )
2017
38
The comorbidity burden of patients with cluster headache: a population-based study. ( 28741257 )
2017
39
Sphenopalatine ganglion stimulation induces changes in cardiac autonomic regulation in cluster headache. ( 29105279 )
2017
40
Optimal deep brain stimulation site and target connectivity for chronic cluster headache. ( 29030455 )
2017
41
Childhood-Onset Cluster Headache: Observations From a Personal Case-Series and Review of the Literature. ( 29226466 )
2017
42
Cluster headache - clinical pattern and a new severity scale in a Swedish cohort. ( 28906127 )
2017
43
CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data. ( 29110503 )
2017
44
Long-term effectiveness of sphenopalatine ganglion stimulation for cluster headache. ( 27165493 )
2016
45
Occipital nerve stimulation improves the quality of life in medically-intractable chronic cluster headache: Results of an observational prospective study. ( 27697849 )
2016
46
Bout-associated intrinsic functional network changes in cluster headache: A longitudinal resting-state functional MRI study. ( 27605571 )
2016
47
Trigeminal Autonomic Cephalalgias in Children and Adolescents: Cluster Headache and Related Conditions. ( 27017018 )
2016
48
Noninvasive vagus nerve stimulation in the management of cluster headache: clinical evidence and practical experience. ( 27134678 )
2016
49
Long-term occipital nerve stimulation for drug-resistant chronic cluster headache. ( 27250232 )
2016
50
Cluster headache attack remission with sphenopalatine ganglion stimulation: experiences in chronic cluster headache patients through 24A months. ( 27461394 )
2016

Variations for Cluster Headache

Expression for Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for Cluster Headache

Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 CACNA1A CLOCK NOS1
2
Show member pathways
11.62 CACNA1A CALCA NOS1
3 11.46 CALCA HCRT NOS1 VIP
4 10.93 CACNA1A NOS1

GO Terms for Cluster Headache

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.86 CALCA HCRT HCRTR2 VIP
2 regulation of receptor activity GO:0010469 9.72 CALCA HCRT VIP
3 chemical synaptic transmission GO:0007268 9.63 CACNA1A HCRT HCRTR2
4 regulation of insulin secretion GO:0050796 9.54 CACNA1A CLOCK
5 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.52 HCRT HCRTR2
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.51 CALCA VIP
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.5 CACNA1A CALCA HCRT
8 response to heat GO:0009408 9.49 CALCA NOS1
9 regulation of cytosolic calcium ion concentration GO:0051480 9.48 CALCA HCRTR2
10 negative regulation of blood pressure GO:0045776 9.43 CALCA NOS1
11 vasodilation GO:0042311 9.4 CALCA NOS1
12 response to pain GO:0048265 9.37 CACNA1A CALCA
13 neuropeptide signaling pathway GO:0007218 9.33 CALCA HCRT HCRTR2
14 negative regulation of potassium ion transport GO:0043267 9.26 HCRT NOS1
15 negative regulation of calcium ion transport into cytosol GO:0010523 8.96 CALCA NOS1
16 feeding behavior GO:0007631 8.8 CALCA HCRT HCRTR2

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.62 HCRT VIP

Sources for Cluster Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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