MCID: CLS010
MIFTS: 40

Cluster Headache malady

Neuronal diseases category

Summaries for Cluster Headache

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.  a cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  in some individuals, it may be preceded by a migraine-like "aura." the pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. males are much more likely than females to develop cluster headaches.  last updated: 5/1/2008

MalaCards: Cluster Headache is related to migraine and sleep disorder. An important gene associated with Cluster Headache is HCRTR2 (hypocretin (orexin) receptor 2), and among its related pathways are Phenylalanine metabolism and Cytochrome P450 - arranged by substrate type. The drugs cyproheptadine and dihydroergotamine and the compounds estrogen and triptan have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:63 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Aliases & Classifications for Cluster Headache

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Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

cluster headache 42 44 60


External Ids:

ICD1025 G44.0

Related Diseases for Cluster Headache

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to cluster headache

Clinical Features for Cluster Headache

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Drugs & Therapeutics for Cluster Headache

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cluster Headache

Drug clinical trials:

Search ClinicalTrials for Cluster Headache

Search NIH Clinical Center for Cluster Headache

Search CenterWatch for Cluster Headache

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cluster Headache

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Anatomical Context for Cluster Headache

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32MalaCards
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MalaCards organs/tissues related to Cluster Headache:

32
Eye

Animal Models for Cluster Headache or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cluster Headache:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0CALCA, CACNA1A, HTR3A, NPY, AKR1A1, HFE
2MP:00053868.4ADH7, VIP, CALCA, CACNA1A, HTR1B, HTR3A

Publications for Cluster Headache

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Genetic Variations for Cluster Headache

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Expression for genes affiliated with Cluster Headache

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for genes affiliated with Cluster Headache

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 51QIAGEN
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Pathways related to Cluster Headache according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2ADH7, ADH4
2
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10.2ADH7, ADH4
3
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10.0HTR1B, HTR3A, HTR1D
4
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10.0ADH7, ADH4, AKR1A1
5
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10.0ADH7, ADH4, AKR1A1
6
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9.7CACNA1A, GNB3, HTR1B, HTR3A, HTR1D
7
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9.6CACNA1A, GNB3, HTR1B, HTR3A, HTR1D, CLOCK
8
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9.4PNOC, CALCA, GNB3, HTR1B, HTR1D, NPY
9
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9.3VIP, CALCA, GNB3, HTR1B, HTR1D, NPY

Compounds for genes affiliated with Cluster Headache

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Cluster Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6PNOC
2triptan4410.5CALCA, HTR3A, HTR1B
3helospectin4410.5VIP, CALCA, NPY
4frovatriptan44 1111.4HTR1B, HTR3A, HTR1D
5cyanopindolol44 2811.4HTR3A, HTR1B, HTR1D
6rizatriptan44 28 1112.4HTR1D, CALCA, HTR1B
7hexamethonium44 2811.4PNOC, CALCA, VIP
8ru 2496928 4411.4HTR1D, HTR3A, HTR1B
92-methyl-5-ht44 2811.4HTR1B, HTR3A, HTR1D
10ipsapirone44 2811.4HTR1B, HTR1D, HTR3A
115-carboxamidotryptamine4410.4HTR3A, HTR1D, HTR1B
12almotriptan44 1111.4HTR1B, HTR1D, HTR3A
13dihydroergotamine28 44 1112.4HTR1B, HTR3A, HTR1D
14zotepine44 2811.3HTR1B, HTR1D, HTR3A
15methiothepin44 2811.3HTR1B, HTR1D, HTR3A
16atropine44 28 1112.3NPY, CALCA, PNOC
17guanethidine44 1111.3PNOC, NPY, CALCA, VIP
18ritanserin28 4411.3HTR3A, HTR1D, HTR1B
19metergoline44 2811.3HTR1B, HTR3A, HTR1D
20methysergide44 28 1112.2HTR1B, HTR1D, HTR3A
21yohimbine44 28 2 1113.2HTR3A, HTR1B, NPY, HTR1D
22acetylcholine44 49 28 11 2414.2CALCA, CACNA1A, HTR3A, HCRTR2, PNOC
23tryptamine44 28 2412.2HTR1B, HTR3A, HTR1D
24tetrodotoxin44 59 2812.2NPY, VIP, CALCA, HTR3A
25melatonin44 59 28 11 2414.2HTR3A, CLOCK, IL2RB
26olanzapine49 44 28 11 2414.2HTR1B, HTR1D, GNB3, HTR3A
27propranolol44 28 49 11 2414.2HTR3A, HTR1B, CALCA, VIP, HTR1D
28fenfluramine28 44 1112.1HTR3A, NPY, HTR1B
29thyroxine44 2411.1NPY, HP, IL2RB, CALCA, VIP
30capsaicin44 2811.1CALCA, NPY, S100A12, VIP, PNOC
31ergotamine28 44 1112.1HTR1D, HTR3A, HTR1B
32sumatriptan44 28 59 49 11 2415.1CALCA, VIP, GNB3, HTR1B, HTR3A, HTR1D
33ketanserin28 4411.0HTR1B, HTR3A, HTR1D
34vitamin a44 11 2411.9ADH7, ADH4, AKR1A1, SERPINA1, HP
35acth449.9VIP, CALCA, HCRTR2, NPY, SERPINA1, IL2RB
36ethanol44 49 11 2412.9ADH4, SERPINA1, HP, AKR1A1, ADH7, HFE
37haloperidol44 28 2 49 1113.9NPY, AKR1A1, VIP, HTR1D, IL2RB, HTR3A
38clozapine44 28 49 1112.9HTR1D, HTR3A, HTR1B, GNB3
39gaba449.8PNOC, HTR3A, NPY, VIP, AKR1A1
40lactate449.8CALCA, NPY, AKR1A1, HP, VIP, IL2RB
41cyclic amp44 2410.7IL2RB, NPY, PNOC, HTR1B, HTR1D, VIP
42dopamine44 28 11 2412.7HTR3A, HTR1D, NPY, AKR1A1, CLOCK, PNOC
43histamine44 28 2411.7HTR3A, PNOC, IL2RB, HCRTR2, AKR1A1, NPY
44epinephrine44 11 2411.7CALCA, VIP, HP, NPY, GNB3
455-hydroxytryptamine449.6HTR1D, VIP, CALCA, HTR1B, HTR3A, PNOC
46adenylate449.6CALCA, HTR3A, HTR1D, NPY, AKR1A1, HP
47alanine449.6PNOC, HFE, AKR1A1, VIP, HCRTR2, HP
48norepinephrine44 11 2411.6CALCA, HTR3A, PNOC, IL2RB, HCRTR2, NPY
49nitric oxide44 11 2411.5GNB3, CALCA, IL2RB, HTR1B, HP, PNOC
50creatinine449.2HP, SERPINA1, AKR1A1, CALCA, IL2RB, NPY

GO Terms for genes affiliated with Cluster Headache

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16Gene Ontology
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Cellular components related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.9VIP, CALCA, CACNA1A, HTR3A
2integral to plasma membraneGO:0058879.6HTR3A, HTR1D, HFE, HCRTR2, IL2RB, HTR1B
3extracellular regionGO:0055769.2ADH7, VIP, CALCA, S100A12, NPY, HP
4plasma membraneGO:0058868.6CACNA1A, S100A12, GNB3, HTR1B, HTR3A, HTR1D

Biological processes related to Cluster Headache according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00763110.3HCRTR2, NPY, CALCA
2regulation of behaviorGO:05079510.3HTR1B, HTR1D
3ethanol oxidationGO:00606910.3ADH4, ADH7
4cellular aldehyde metabolic processGO:00608110.2AKR1A1, ADH4
5G-protein coupled receptor internalizationGO:00203110.2CALCA, HTR1B
6regulation of blood pressureGO:00821710.2CALCA, GNB3, NPY
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.2NPY, HTR1D, HTR1B
8vasoconstrictionGO:04231010.1HTR1D, HTR1B
9neuropeptide signaling pathwayGO:00721810.1CALCA, NPY, HCRTR2, PNOC
10monocyte chemotaxisGO:0025489.9S100A12, CALCA
11defense response to bacteriumGO:0427429.8S100A12, ANXA3, HP
12synaptic transmissionGO:0072689.5PNOC, CACNA1A, GNB3, HTR1B, HTR3A, HTR1D

Molecular functions related to Cluster Headache according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:00402410.3ADH4, ADH7
2retinol dehydrogenase activityGO:00474510.2ADH7, ADH4
3serotonin bindingGO:05137810.2HTR1D, HTR3A, HTR1B
4neuropeptide hormone activityGO:00518410.1VIP, NPY, PNOC
5serotonin receptor activityGO:00499310.1HTR1D, HTR3A, HTR1B
6alditol:NADP+ 1-oxidoreductase activityGO:00403210.1ADH4, AKR1A1
7alcohol dehydrogenase (NAD) activityGO:00402210.1ADH7, ADH4
8retinol bindingGO:0198419.9ADH7, ADH4

Products for genes affiliated with Cluster Headache

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  • Antibodies
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Sources for Cluster Headache

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet