MCID: CLS010
MIFTS: 43

Cluster Headache malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Cluster Headache

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS, 25ICD10
See all sources

Aliases & Descriptions for Cluster Headache:

Name: Cluster Headache 42 44 61


Classifications:



External Ids:

ICD1025 G44.0

Summaries for Cluster Headache

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NIH Rare Diseases:42 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.  a cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  in some individuals, it may be preceded by a migraine-like "aura." the pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. males are much more likely than females to develop cluster headaches.  last updated: 5/1/2008

MalaCards based summary: Cluster Headache is related to migraine and headache. An important gene associated with Cluster Headache is HCRTR2 (hypocretin (orexin) receptor 2), and among its related pathways are Adenylate cyclase activating neuropeptides and G alpha (s) signalling events. The drugs cyproheptadine and dihydroergotamine and the compounds triptan and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related mouse phenotypes are immune system and behavior/neurological.

Wikipedia:64 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Related Diseases for Cluster Headache

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Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to cluster headache

Symptoms for Cluster Headache

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Drugs & Therapeutics for Cluster Headache

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Genetic Tests for Cluster Headache

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Anatomical Context for Cluster Headache

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MalaCards organs/tissues related to Cluster Headache:

31
Eye, Brain, Hypothalamus, Testes, Spinal cord, Pituitary, Heart, Pineal, Lung, Neutrophil

Animal Models for Cluster Headache or affiliated genes

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MGI Mouse Phenotypes related to Cluster Headache:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0CACNA1A, HP, HTR3A, VIP
2MP:00053867.6CALCA, CACNA1A, HTR3A, VIP, HCRTR2
3MP:00053767.4VIP, HTR3A, HP, CACNA1A, CALCA
4MP:00107687.2VIP, HTR3A, HP, CACNA1A, CALCA

Publications for Cluster Headache

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Articles related to Cluster Headache:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Abnormal coactivation of the hypothalamus and salience network in patients with cluster headache. (25746559)
2015
2
Value of intra- and post-operative cone beam computed tomography (CBCT) for positioning control of a sphenopalatine ganglion neurostimulator in patients with chronic cluster headache. (25648069)
2015
3
Study of cluster headache: A hospital-based study. (25288839)
2014
4
Corticosteroids alter CGRP and melatonin release in cluster headache episodes. (24958681)
2014
5
Lateralized nociceptive blink reflex habituation deficit in episodic cluster headache: Correlations with clinical features. (25228682)
2014
6
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
7
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
8
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
9
Cluster headache: what has changed since 1999? (23695050)
2013
10
Changes in Plasma Methionine-Enkephalin Levels Associated With a Cluster Headache Episode. (23353772)
2013
11
Cluster headache associated with acute maxillary sinusitis. (24133652)
2013
12
Cluster headache and arachnoid cyst. (23419954)
2013
13
Use of cannabis among 139 cluster headache sufferers. (23197349)
2013
14
Cluster headache and sleep, is there a connection? A review. (22407656)
2012
15
A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache. (22581595)
2012
16
Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: Experience in five patients with a modified anatomical target. (22116943)
2011
17
Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. (21848953)
2011
18
Peripheral neurostimulation for the treatment of refractory cluster headache, long-term follow-up: case report. (21854497)
2011
19
Needle-free subcutaneous sumatriptan: in the acute treatment of migraine attacks or cluster headache episodes. (22054121)
2011
20
Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. (21349186)
2011
21
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
22
Secondary chronic cluster headache due to trigeminal nerve root compression. (20384588)
2010
23
Allodynia in cluster headache. (20425203)
2010
24
Can response to indomethacin exclude the diagnosis of cluster headache? (20656700)
2010
25
Role of sphenopalatine ganglion neuroablation in the management of cluster headache. (20425206)
2010
26
Oxygen treatment in acute cluster headache. (19272273)
2009
27
Genetic aspects of cluster headache. (19271945)
2009
28
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
29
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
30
Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. (19330286)
2009
31
Use of complementary and alternative medicine by patients with cluster headache: results of a multi-centre headache clinic survey. (18638713)
2008
32
Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache. (18547217)
2008
33
Reduced habituation of trigeminal reflexes in patients with episodic cluster headache during cluster period. (18624808)
2008
34
Internal carotid artery dissection presenting as cluster headache. (18949282)
2008
35
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
36
The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. (17539953)
2007
37
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
38
Using ice cream headache to help physicians experience the pain of and empathize with cluster headache patients. (16288968)
2006
39
Cluster headache due to internal carotid artery dissection. (16541217)
2006
40
Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache. (16885751)
2006
41
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
42
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
43
Decreasing incidence of cluster headache: a population-based study in Olmsted County, Minnesota. (15836596)
2005
44
Cluster headache from the patient's point of view. (15745622)
2005
45
Cluster headache: diagnosis and treatment. (15745625)
2005
46
Cluster headache with obstructive sleep apnea and periodic limb movements during sleep: a case report. (15663620)
2005
47
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
48
Subcutaneous sumatriptan induces changes in frequency pattern in cluster headache patients. (15209695)
2004
49
Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. (7516861)
1994
50
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991

Variations for Cluster Headache

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Expression for genes affiliated with Cluster Headache

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Search GEO for disease gene expression data for Cluster Headache.

Pathways for genes affiliated with Cluster Headache

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Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CALCA, VIP

Compounds for genes affiliated with Cluster Headache

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Compounds related to Cluster Headache according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1triptan449.8HTR3A, CALCA
2hydroxyproline44 24 1111.8HP, CALCA
3helospectin449.6CALCA, VIP
4cromakalim44 2810.6VIP, CALCA
5hexamethonium44 2810.6VIP, CALCA
6guanethidine44 1110.6CALCA, VIP
7sodium fluoride449.6VIP, CALCA
8mibg449.6VIP, CALCA
9thiorphan44 28 1111.6VIP, CALCA
10n(g)-nitro-l-arginine methyl ester449.6VIP, CALCA
11ng-nitro-l-arginine449.6CALCA, VIP
12phosphoramidon44 1110.6CALCA, VIP
13nitroglycerin44 1110.6CALCA, VIP
14captopril44 60 50 28 1113.5CALCA, VIP
15methacholine44 50 1111.5VIP, CALCA
16glibenclamide44 28 50 6012.5CALCA, VIP
17anaphylatoxin449.5HP, VIP
18capsaicin44 2810.5VIP, CALCA
19octreotide44 60 28 1112.5CALCA, VIP
20prostaglandin f2alpha449.5CALCA, VIP
21atropine44 28 1111.5VIP, CALCA
225-hydroxyindoleacetic acid44 2410.4HTR3A, VIP
23corticosterone44 60 2411.4CALCA, VIP
24polyethylene glycol449.3HP, VIP
25melatonin44 28 60 24 1113.3VIP, HTR3A
26catecholamine449.2VIP, HCRTR2
27gp 130449.2HP, VIP
28verapamil44 28 50 24 1113.1CACNA1A, VIP
29thyroxine44 2410.1CALCA, HP, VIP
30haloperidol44 50 28 1 1113.1HTR3A, VIP
31epinephrine44 24 1111.1CALCA, VIP, HP
32cyclosporin a44 28 6011.0HP, VIP, CALCA
33pge2449.0CALCA, VIP, HP
34sumatriptan44 28 60 50 24 1114.0CALCA, HTR3A, VIP
35lactate449.0CALCA, HP, VIP
36tetrodotoxin44 60 2811.0CALCA, HTR3A, VIP
37propranolol44 28 50 24 1113.0CALCA, VIP, HTR3A
385-hydroxytryptamine449.0HTR3A, CALCA, VIP
39testosterone44 60 24 1111.9VIP, HP, CALCA
40dopamine44 28 24 1111.9HTR3A, VIP, CALCA
41acth448.7HP, CALCA, VIP, HCRTR2
42dexamethasone44 50 28 1111.7VIP, HP, HTR3A
43norepinephrine44 24 1110.6CALCA, HTR3A, VIP, HCRTR2
44histamine44 28 2410.6CALCA, HTR3A, VIP, HCRTR2
45vegf448.6HP, VIP, CALCA
46glutamate448.6CALCA, VIP, HP, CACNA1A
47adenylate448.5VIP, HP, CALCA, HTR3A
48nitric oxide44 24 1110.4VIP, CALCA, HP
49calcium44 50 24 1111.1CACNA1A, CALCA, HP, VIP, HCRTR2
50acetylcholine44 50 28 24 1112.1HCRTR2, HTR3A, VIP, CACNA1A, CALCA

GO Terms for genes affiliated with Cluster Headache

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Cellular components related to Cluster Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.1CALCA, CACNA1A, HTR3A, VIP

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00076319.6CALCA, HCRTR2
2positive regulation of cytosolic calcium ion concentrationGO:00072049.5CALCA, CACNA1A
3neuropeptide signaling pathwayGO:00072189.3CALCA, HCRTR2
4positive regulation of vasodilationGO:00459099.3CALCA, VIP
5synaptic transmissionGO:00072688.8HCRTR2, HTR3A, CACNA1A

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.2CALCA, VIP

Sources for Cluster Headache

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet