MCID: CLS010
MIFTS: 50

Cluster Headache malady

Rare diseases, Neuronal diseases categories
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Summaries for Cluster Headache

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.  a cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  in some individuals, it may be preceded by a migraine-like "aura." the pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. males are much more likely than females to develop cluster headaches.  last updated: 5/1/2008

MalaCards: Cluster Headache is related to migraine and headache. An important gene associated with Cluster Headache is HCRTR2 (hypocretin (orexin) receptor 2), and among its related pathways are Adenylate cyclase activating neuropeptides and G alpha (s) signalling events. The drugs cyproheptadine and dihydroergotamine and the compounds triptan and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related mouse phenotypes are immune system and behavior/neurological.

Wikipedia:65 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Aliases & Classifications for Cluster Headache

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Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

cluster headache 43 45 62


External Ids:

ICD1025 G44.0

Related Diseases for Cluster Headache

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to cluster headache

Symptoms for Cluster Headache

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Drugs & Therapeutics for Cluster Headache

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Cluster Headache

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Anatomical Context for Cluster Headache

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Sources:
33MalaCards
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MalaCards organs/tissues related to Cluster Headache:

33
Eye, Brain, Hypothalamus, Testes, Spinal cord, Heart, Pineal, Pituitary, Lung

Animal Models for Cluster Headache or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cluster Headache:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0CACNA1A, HP, HTR3A, VIP
2MP:00053867.6CALCA, HCRTR2, VIP, HTR3A, CACNA1A
3MP:00053767.4HTR3A, HP, CACNA1A, CALCA, VIP
4MP:00107687.2CALCA, VIP, HTR3A, HP, CACNA1A

Publications for Cluster Headache

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Sources:
52PubMed
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Articles related to Cluster Headache:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
2
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
3
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
4
Cluster headache: what has changed since 1999? (23695050)
2013
5
Changes in Plasma Methionine-Enkephalin Levels Associated With a Cluster Headache Episode. (23353772)
2013
6
Cluster headache associated with acute maxillary sinusitis. (24133652)
2013
7
Cluster headache and arachnoid cyst. (23419954)
2013
8
Use of cannabis among 139 cluster headache sufferers. (23197349)
2013
9
Cluster headache and sleep, is there a connection? A review. (22407656)
2012
10
Female cluster headache in the United States of America: what are the gender differences? Results from the United States Cluster Headache Survey. (22482825)
2012
11
A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache. (22581595)
2012
12
Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: Experience in five patients with a modified anatomical target. (22116943)
2011
13
Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. (21848953)
2011
14
Peripheral neurostimulation for the treatment of refractory cluster headache, long-term follow-up: case report. (21854497)
2011
15
Acute and preventive pharmacologic treatment of cluster headache. (21980606)
2011
16
Needle-free subcutaneous sumatriptan: in the acute treatment of migraine attacks or cluster headache episodes. (22054121)
2011
17
Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. (21349186)
2011
18
Cluster headache: clinical features and therapeutic options. (21912573)
2011
19
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
20
Secondary chronic cluster headache due to trigeminal nerve root compression. (20384588)
2010
21
Allodynia in cluster headache. (20425203)
2010
22
Can response to indomethacin exclude the diagnosis of cluster headache? (20656700)
2010
23
Role of sphenopalatine ganglion neuroablation in the management of cluster headache. (20425206)
2010
24
Oxygen treatment in acute cluster headache. (19272273)
2009
25
Genetic aspects of cluster headache. (19271945)
2009
26
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
27
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
28
Cluster headache, hypothalamus, and orexin. (19272281)
2009
29
Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. (19330286)
2009
30
Use of complementary and alternative medicine by patients with cluster headache: results of a multi-centre headache clinic survey. (18638713)
2008
31
Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache. (18547217)
2008
32
Reduced habituation of trigeminal reflexes in patients with episodic cluster headache during cluster period. (18624808)
2008
33
Internal carotid artery dissection presenting as cluster headache. (18949282)
2008
34
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
35
The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. (17539953)
2007
36
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
37
Using ice cream headache to help physicians experience the pain of and empathize with cluster headache patients. (16288968)
2006
38
Cluster headache due to internal carotid artery dissection. (16541217)
2006
39
Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache. (16885751)
2006
40
Cluster headache attack due to sildenafil intake. (16674772)
2006
41
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
42
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
43
Decreasing incidence of cluster headache: a population-based study in Olmsted County, Minnesota. (15836596)
2005
44
Cluster headache from the patient's point of view. (15745622)
2005
45
Cluster headache: diagnosis and treatment. (15745625)
2005
46
Cluster headache with obstructive sleep apnea and periodic limb movements during sleep: a case report. (15663620)
2005
47
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
48
Subcutaneous sumatriptan induces changes in frequency pattern in cluster headache patients. (15209695)
2004
49
Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. (7516861)
1994
50
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991

Variations for Cluster Headache

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Expression for genes affiliated with Cluster Headache

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for genes affiliated with Cluster Headache

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Sources:
50PathCards, 12EMD Millipore, 55Reactome
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Pathways related to Cluster Headache according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CALCA, HCRTR2
29.2CALCA, VIP

Compounds for genes affiliated with Cluster Headache

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 3BitterDB
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Compounds related to Cluster Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1triptan459.8CALCA, HTR3A
2hydroxyproline45 24 1111.8CALCA, HP
3helospectin459.6VIP, CALCA
4cromakalim45 2910.6VIP, CALCA
5hexamethonium45 2910.6VIP, CALCA
6guanethidine45 1110.6VIP, CALCA
7sodium fluoride459.6CALCA, VIP
8mibg459.6CALCA, VIP
9thiorphan45 29 1111.6CALCA, VIP
10n(g)-nitro-l-arginine methyl ester459.6VIP, CALCA
11ng-nitro-l-arginine459.6CALCA, VIP
12phosphoramidon45 1110.6CALCA, VIP
13nitroglycerin45 1110.6VIP, CALCA
14captopril45 61 51 29 1113.5CALCA, VIP
15methacholine45 51 1111.5VIP, CALCA
16glibenclamide45 29 51 6112.5CALCA, VIP
17anaphylatoxin459.5HP, VIP
18capsaicin45 2910.5CALCA, VIP
19octreotide45 61 29 1112.5VIP, CALCA
20prostaglandin f2alpha459.5CALCA, VIP
21atropine45 29 1111.5CALCA, VIP
225-hydroxyindoleacetic acid45 2410.4VIP, HTR3A
23corticosterone45 61 2411.4CALCA, VIP
24polyethylene glycol459.3HP, VIP
25melatonin45 29 61 24 1113.3HTR3A, VIP
26catecholamine459.2VIP, HCRTR2
27gp 130459.2HP, VIP
28verapamil45 29 51 24 1113.1CACNA1A, VIP
29thyroxine45 2410.1VIP, HP, CALCA
30haloperidol45 51 29 3 1113.1HTR3A, VIP
31epinephrine45 24 1111.1CALCA, HP, VIP
32cyclosporin a45 29 6111.0CALCA, HP, VIP
33pge2459.0CALCA, HP, VIP
34sumatriptan45 29 61 51 24 1114.0VIP, HTR3A, CALCA
35lactate459.0VIP, HP, CALCA
36tetrodotoxin45 61 2911.0CALCA, HTR3A, VIP
37propranolol45 29 51 24 1113.0VIP, HTR3A, CALCA
385-hydroxytryptamine459.0CALCA, HTR3A, VIP
39testosterone45 61 24 1111.9VIP, HP, CALCA
40dopamine45 29 24 1111.9CALCA, HTR3A, VIP
41acth458.7HCRTR2, VIP, HP, CALCA
42dexamethasone45 51 29 1111.7VIP, HTR3A, HP
43norepinephrine45 24 1110.6CALCA, HTR3A, VIP, HCRTR2
44histamine45 29 2410.6HCRTR2, VIP, HTR3A, CALCA
45vegf458.6VIP, HP, CALCA
46glutamate458.6VIP, HP, CACNA1A, CALCA
47adenylate458.5CALCA, HP, HTR3A, VIP
48nitric oxide45 24 1110.4CALCA, HP, VIP
49calcium45 51 24 1111.1HCRTR2, VIP, HP, CACNA1A, CALCA
50acetylcholine45 51 29 24 1112.1CALCA, CACNA1A, HTR3A, VIP, HCRTR2

GO Terms for genes affiliated with Cluster Headache

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Sources:
16Gene Ontology
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Cellular components related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.1CALCA, CACNA1A, HTR3A, VIP

Biological processes related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:0076319.6HCRTR2, CALCA
2positive regulation of cytosolic calcium ion concentrationGO:0072049.5CACNA1A, CALCA
3neuropeptide signaling pathwayGO:0072189.3HCRTR2, CALCA
4positive regulation of vasodilationGO:0459099.3VIP, CALCA
5synaptic transmissionGO:0072688.8HCRTR2, HTR3A, CACNA1A

Molecular functions related to Cluster Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.2CALCA, VIP

Products for genes affiliated with Cluster Headache

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Sources for Cluster Headache

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet