MCID: CTS003
MIFTS: 57

Coats Disease malady

Categories: Rare diseases, Genetic diseases, Neuronal diseases, Eye diseases, Fetal diseases, Cardiovascular diseases

Aliases & Classifications for Coats Disease

Aliases & Descriptions for Coats Disease:

Name: Coats Disease 54 12 50 24 56 52 14
Exudative Retinopathy 12 29 69
Leber Miliary Aneurysm 50 56
Retinal Telangiectasis 50 42
Congenital Retinal Telangiectasia 56
Coats' Syndrome 12
Coats' Disease 12

Characteristics:

Orphanet epidemiological data:

56
coats disease
Inheritance: Not applicable; Prevalence: <1/1000000 (United Kingdom); Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

OMIM 54 300216
Disease Ontology 12 DOID:7765
ICD10 33 H35.02 H35.07
ICD9CM 35 362.12
MeSH 42 D058456
Orphanet 56 ORPHA190
MESH via Orphanet 43 D058456
UMLS via Orphanet 70 C0154832
ICD10 via Orphanet 34 H35.0
UMLS 69 C0154832

Summaries for Coats Disease

NIH Rare Diseases : 50 coats disease is an eye disorder characterized by abnormal development of the blood vessels in the retina (retinal telangiectasia). most affected people begin showing symptoms of the condition in childhood. early signs and symptoms vary but may include vision loss, crossed eyes (strabismus), and a white mass in the pupil behind the lens of the eye (leukocoria). overtime, coats disease may also lead to retinal detachment, glaucoma, and clouding of the lens of the eye (cataracts) as the disease progresses. in most cases, only one eye is affected (unilateral). the exact underlying cause is not known but some cases may be due to somatic mutations in the ndp gene. treatment depends on the symptoms present and may include cryotherapy, laser therapy, and/or surgery. last updated: 12/15/2014

MalaCards based summary : Coats Disease, also known as exudative retinopathy, is related to gollop coates syndrome and revesz syndrome, and has symptoms including cataract, strabismus and abnormality of the macula. An important gene associated with Coats Disease is FZD4 (Frizzled Class Receptor 4), and among its related pathways/superpathways are Proteoglycans in cancer and Cell adhesion_Plasmin signaling. The drugs Histamine and Mianserin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are no phenotypic analysis and pigmentation

Wikipedia : 71 Coats\' disease, (also known as exudative retinitis or retinal telangiectasis, sometimes spelled... more...

Description from OMIM: 300216

Related Diseases for Coats Disease

Diseases related to Coats Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Related Disease Score Top Affiliating Genes
1 gollop coates syndrome 11.9
2 revesz syndrome 11.7
3 cerebroretinal microangiopathy with calcifications and cysts 10.9
4 idiopathic macular telangiectasia type 3 10.9
5 idiopathic juxtafoveal retinal telangiectasia 10.9
6 idiopathic macular telangiectasia type 1 10.9
7 retinitis 10.2
8 neonatal abstinence syndrome 10.2 FZD4 NDP
9 van buchem disease, type 2 10.2 FZD4 NDP
10 athabaskan brainstem dysgenesis syndrome 10.2 RS1 VEGFA
11 congenital ichthyosiform erythroderma 10.2 RS1 VEGFA
12 kidney osteogenic sarcoma 10.1 KDR VEGFA
13 congenital hypogammaglobulinemia 10.1 NDP RS1
14 hand, foot and mouth disease 10.1 KDR VEGFA
15 cone-rod dystrophy 17 10.1 KDR VEGFA
16 multilocular clear cell renal cell carcinoma 10.1 RS1 VEGFA
17 vesiculobullous skin disease 10.1 KDR VEGFA
18 intracranial hypotension 10.1 KDR VEGFA
19 neuropathy with hearing impairment 10.1 KDR VEGFA
20 adult infiltrating astrocytic neoplasm 10.1 RS1 VEGFA
21 benign idiopathic neonatal seizures 10.1 KDR VEGFA
22 respiratory syncytial virus infectious disease 10.1 NDP VEGFA
23 upper respiratory tract disease 10.1 RS1 VEGFA
24 phlegmonous dacryocystitis 10.1 KDR VEGFA
25 factitious disorder 10.1 KDR VEGFA
26 ovarian disease 10.1 KDR VEGFA
27 maxillary sinus cancer 10.1 CRB1 RS1
28 benign familial neonatal epilepsy 10.1 KDR VEGFA
29 neurilemmoma of the pleura 10.0 KDR VEGFA
30 astigmatism 10.0 FZD4 NDP RS1
31 smed strudwick type 10.0 NDP RS1
32 brucella canis brucellosis 10.0 RS1 VEGFA
33 mitral valve stenosis 10.0 KDR VEGFA
34 retinal detachment 9.9
35 adult liposarcoma 9.9 CRB1 NDP RS1
36 retinoblastoma 9.9
37 cornea plana 9.9 FZD4 NDP TSPAN12
38 nystagmus 5, congenital, x-linked 9.9 FZD4 NDP TSPAN12
39 epileptic encephalopathy, early infantile, 1 9.9 NDP RS1
40 muscular dystrophy 9.9
41 endotheliitis 9.9
42 dyskeratosis congenita 9.8
43 macular holes 9.8
44 telangiectasis 9.7
45 retinitis pigmentosa 9.7
46 cornelia de lange syndrome 9.7
47 uveitis 9.7
48 neovascular glaucoma 9.7
49 exudative vitreoretinopathy 9.6
50 retinoschisis 9.6

Graphical network of the top 20 diseases related to Coats Disease:



Diseases related to Coats Disease

Symptoms & Phenotypes for Coats Disease

Clinical features from OMIM:

300216

Human phenotypes related to Coats Disease:

56 32 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cataract 56 32 Occasional (29-5%) HP:0000518
2 strabismus 56 32 Very frequent (99-80%) HP:0000486
3 abnormality of the macula 56 32 Frequent (79-30%) HP:0001103
4 abnormality of the retinal vasculature 56 32 Very frequent (99-80%) HP:0008046
5 glaucoma 56 32 Frequent (79-30%) HP:0000501
6 retinal detachment 56 32 Frequent (79-30%) HP:0000541
7 aplasia/hypoplasia of the iris 56 32 Occasional (29-5%) HP:0008053
8 abnormality of the anterior chamber 56 32 Occasional (29-5%) HP:0000593

MGI Mouse Phenotypes related to Coats Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.55 CTC1 FZD4 KDR NDP VEGFA
2 pigmentation MP:0001186 9.26 CRB1 FZD4 NDP RS1
3 vision/eye MP:0005391 9.17 CRB1 FZD4 KDR NDP RS1 TSPAN12

Drugs & Therapeutics for Coats Disease

Drugs for Coats Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1192)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
2
Mianserin Approved Phase 4,Phase 3 24219-97-4 4184
3
Mirtazapine Approved Phase 4,Phase 3 85650-52-8, 61337-67-5 4205
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
6
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
9
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
12
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
13
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
14
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
15
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
16
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
17
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757 53477783
18
Norethindrone Approved Phase 4 68-22-4 6230
19
Glatiramer Acetate Approved, Investigational Phase 4,Phase 3,Phase 2 147245-92-9 3081884
20
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
21
Povidone-iodine Approved Phase 4 25655-41-8
22 Trapidil Approved Phase 4 15421-84-8
23
Adefovir Dipivoxil Approved, Investigational Phase 4,Phase 3,Phase 2 142340-99-6 60871
24
Telbivudine Approved, Investigational Phase 4,Phase 3 3424-98-4 159269
25
Acetylcholine Approved Phase 4,Phase 3 51-84-3 187
26
Triclosan Approved Phase 4 3380-34-5 5564
27
Phenobarbital Approved Phase 4 50-06-6 4763
28
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
29
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
30
Hyoscyamine Approved Phase 4 101-31-5 64692
31
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
32
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
33
Ticagrelor Approved Phase 4,Phase 2 274693-27-5 9871419
34
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
35
Cimetidine Approved Phase 4 51481-61-9 2756
36
Hydroquinone Approved Phase 4,Phase 3 123-31-9 785
37
Diclofenac Approved, Vet_approved Phase 4,Phase 2,Phase 1 15307-86-5 3033
38
Etoricoxib Approved, Investigational Phase 4,Phase 2 202409-33-4 123619
39
Sucralfate Approved Phase 4 54182-58-0
40
Cyproterone Acetate Approved, Investigational Phase 4,Phase 3 427-51-0
41
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
42
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
43
Metformin Approved Phase 4,Phase 3,Phase 1,Phase 2 657-24-9 14219 4091
44
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2 152923-56-3, 179045-86-4
45
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
46
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
47
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2 3056-17-5 18283
48
Glycerol Approved, Experimental Phase 4,Phase 3,Phase 2 56-81-5 753
49
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
50
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 55-56-1 9552079 2713

Interventional clinical trials:

(show top 50) (show all 2451)
id Name Status NCT ID Phase
1 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy Unknown status NCT00150839 Phase 4
2 Platelet Function With New Pediatric Oxygenator and Heparin and Non Heparin Coating in Pediatric Cardiac Surgery Unknown status NCT01648712 Phase 4
3 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4
4 Study of the Paclitaxel-Coated Balloon Catheter in Bifurcated Coronary Lesions Unknown status NCT01278186 Phase 4
5 Non-Polymer-Based, Rapamycin-Eluting Stents to Prevent Restenosis Unknown status NCT00152308 Phase 4
6 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4
7 COMPETE: A Clinical Evaluation of Chrono Carbostent Carbofilm™ Coated Stent Unknown status NCT00920283 Phase 4
8 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
9 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
10 Test Efficacy of Biodegradable and Permanent Limus-Eluting Stents Unknown status NCT01068106 Phase 4
11 Treatment of Bifurcated Coronary Lesions With Cypher™-Stent Unknown status NCT00288535 Phase 4
12 Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy Unknown status NCT02264743 Phase 4
13 Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease Unknown status NCT01418794 Phase 4
14 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
15 Effects of Copaxone in the Retinal Function in Diabetic Patients After Panphotocoagulation Unknown status NCT00677664 Phase 4
16 Comparison of Iodine + Isopropyl Alcohol Versus Iodine + Antimicrobial Sealant for Skin Preparation Unknown status NCT01110772 Phase 4
17 TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography Unknown status NCT01972022 Phase 4
18 Optical Coherence Tomography (OCT) Evaluation of Re-endothelization: A Comparison of the Intrepide™ Stent Versus Taxus™ Unknown status NCT00914420 Phase 4
19 Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII Unknown status NCT01918150 Phase 4
20 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4
21 Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity Unknown status NCT02009540 Phase 4
22 Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery Unknown status NCT01457859 Phase 4
23 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
24 Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PA Unknown status NCT01670474 Phase 4
25 Telaprevir in Genotype 3 HCV Unknown status NCT02087111 Phase 4
26 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
27 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4
28 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
29 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
30 A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis Unknown status NCT01838174 Phase 4
31 Efficacy of Ticagrelor vs Clopidogrel in High-risk NSTE-ACS Patients Undergoing Early PCI Unknown status NCT02201667 Phase 4
32 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
33 Clinical Trial of Hydroquinone Versus Miconazol in Melasma Unknown status NCT01661556 Phase 4
34 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4
35 Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? Unknown status NCT01997762 Phase 4
36 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4
37 ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial Unknown status NCT02016807 Phase 4
38 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4
39 Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease Completed NCT00229528 Phase 4
40 Randomized Trial Comparing Titan Stent With Zotarolimus-Eluting Stent Completed NCT00492908 Phase 4
41 Paclitaxel-coated Balloons in Femoral Indication to Defeat Restenosis Completed NCT01083030 Phase 4
42 A Bioequivalence Study of Cefadroxil Film Coated Tablets After A Single Oral Dose Administration to Healthy Subjects Completed NCT02446496 Phase 4
43 Myfortic, Prograf, and Corticosteroids in de Novo Liver Transplantation Completed NCT01467011 Phase 4
44 The Influence of Smoking Status on Prasugrel and Clopidogrel Treated Subjects Taking Aspirin and Having Stable Coronary Artery Disease Completed NCT01260584 Phase 4
45 OXEMET™ 1000 mg Coated Tablets (Metformin Hydrochloride) Bioequivalence Study. OXEMET (TM) is a Trademark of the GlaxoSmithKline Group of Companies. GLAFORNIL(TM) is a Trademark of Merck. Completed NCT01842620 Phase 4
46 Clinical Use of an Absorbable Coated Suture Material in Surgery (Safil) Completed NCT00645684 Phase 4
47 3 Limus Agent Eluting Stents With Different Polymer Coating Completed NCT00598676 Phase 4
48 Rapamycin-Eluting Stents With Different Polymer Coating to Reduce Restenosis (ISAR-TEST-3) Completed NCT00350454 Phase 4
49 The Impact of Using Triclosan-antibacterial Sutures on the Incidence of Surgical Site Infection Completed NCT01019447 Phase 4
50 Kidney Graft Function Under the Immunosuppression Strategies Completed NCT01817322 Phase 4

Search NIH Clinical Center for Coats Disease

Cochrane evidence based reviews: retinal telangiectasis

Genetic Tests for Coats Disease

Genetic tests related to Coats Disease:

id Genetic test Affiliating Genes
1 Exudative Retinopathy 29
2 Coats Disease 24

Anatomical Context for Coats Disease

MalaCards organs/tissues related to Coats Disease:

39
Eye, Retina, Endothelial, Brain

Publications for Coats Disease

Articles related to Coats Disease:

(show top 50) (show all 271)
id Title Authors Year
1
Serum hypercoagulability states in Coats' disease. ( 28223774 )
2017
2
Angio-OCT findings in Coats' disease. ( 28526523 )
2017
3
Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience. ( 28461016 )
2017
4
Optical Coherence Tomography and Optical Coherence Tomography Angiography in Monitoring Coats' Disease. ( 28377823 )
2017
5
LONG-TERM ANATOMICAL AND FUNCTIONAL OUTCOMES FOLLOWING VITRECTOMY FOR ADVANCED COATS DISEASE. ( 27984550 )
2016
6
A Case of Coats Disease and Concurrent Anisometropic Amblyopia. ( 28090595 )
2016
7
Uveal Melanoma Mimicking Advanced Coats' Disease in a Young Patient. ( 27239453 )
2016
8
Subretinal Fluid Drainage and Vitrectomy Are Helpful in Diagnosing and Treating Eyes with Advanced Coats' Disease. ( 27462247 )
2016
9
Coats' disease and retrobulbar haemodynamics. ( 26686879 )
2016
10
Coats' disease with macular oedema responsive to aflibercept and argon laser. ( 28038924 )
2016
11
Coats' disease of adult-onset in 48 eyes. ( 27609165 )
2016
12
Teaching NeuroImages: Coats disease revealing facioscapulohumeral muscular dystrophy. ( 27462044 )
2016
13
SUBFOVEAL NODULE IN COATS' DISEASE: Toward an Updated Classification Predicting Visual Prognosis. ( 28030429 )
2016
14
EXTRAMACULAR FIBROSIS IN COATS' DISEASE. ( 26991649 )
2016
15
Coats' Disease: Very Long-Term Outcome After Early Stage Conventional Treatment. ( 27014383 )
2016
16
A Case of Anterior Chamber Cholesterolosis Due to Coats' Disease and a Review of Reported Cases. ( 27014384 )
2016
17
Haploinsufficiency of RCBTB1 is associated with Coats disease and familial exudative vitreoretinopathy. ( 26908610 )
2016
18
Intravitreal Bevacizumab as an adjunct to laser in the management of adult onset Coats' disease. ( 27234923 )
2016
19
Optical Coherence Tomography Angiography Findings in Coats' Disease. ( 27549879 )
2016
20
Ultra-wide field imaging in the diagnosis and management of adult-onset Coats' disease. ( 27476647 )
2016
21
"Mommy... I Can't See With My Eye". Coats disease with foveal exudation (Stage 2b). ( 27018878 )
2016
22
Differences in aqueous concentrations of cytokines in paediatric and adult patients with Coats' disease. ( 27364629 )
2016
23
Risk of Tractional Retinal Detachment Following Intravitreal Bevacizumab Along with Subretinal Fluid Drainage and Cryotherapy for Stage 3B Coats' Disease. ( 27162454 )
2016
24
Optical Coherence Tomography Angiography Findings in Coats' Disease. ( 27434894 )
2016
25
iTRAQ-Based Proteomics Investigation of Aqueous Humor from Patients with Coats' Disease. ( 27416065 )
2016
26
Evaluation of Follow-Up and Treatment Results in Coats' Disease. ( 28058165 )
2016
27
Intravitreal bevacizumab injections combined with laser photocoagulation for adult-onset Coats' disease. ( 27270347 )
2016
28
Treatment of Coats' Disease With Combination Therapy of Intravitreal Bevacizumab, Laser Photocoagulation, and Sub-Tenon Corticosteroids. ( 27183548 )
2016
29
Retinoblastoma versus advanced Coats' disease: Is enucleation the answer? ( 27435805 )
2016
30
INTRAVITREAL RANIBIZUMAB AS AN ADJUNCTIVE TREATMENT FOR COATS DISEASE (6-YEAR FOLLOW-UP). ( 27472513 )
2016
31
Successful use of intravitreal ranibizumab injection and combined treatment in the management of Coats' disease. ( 27150442 )
2016
32
Anesthetic Management of an Unusual Case of Coats' Disease Complex: Use of Dexmedetomidine. ( 26237668 )
2015
33
577-NM YELLOW LASER PHOTOCOAGULATION FOR COATS DISEASE. ( 26579790 )
2015
34
Intravitreal bevacizumab injections combined with laser photocoagulation for adult-onset Coats' disease. ( 26631136 )
2015
35
CLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF COATS DISEASE IN A SAUDI ARABIAN POPULATION. ( 25978728 )
2015
36
Treatment of stage 3 Coats' disease by endolaser photocoagulation via a two-port pars plana nonvitrectomy approach. ( 25794987 )
2015
37
A Case of Coats' Disease with Spontaneous Retinal Reattachment after Total Detachment. ( 26265905 )
2015
38
Pearls and pitfalls in diagnosis and management of coats disease. ( 25811949 )
2015
39
An interesting case of Coats' disease. ( 26663970 )
2015
40
A 6-year-old boy with Cornelia de Lange syndrome and Coats disease: case report and review of the literature. ( 26486036 )
2015
41
Case of adult-onset Coats' disease with epiretinal membrane treated with 25-gauge pars plana vitrectomy. ( 25817290 )
2015
42
Multiple Arterial Macroaneurysms in Acquired Coats' Disease in an Adult - A Case Report. ( 25902131 )
2015
43
A Case of Congenital Simple Hamartoma of the Retinal Pigment Epithelium and Coats' Disease in the Same Eye. ( 26240514 )
2015
44
Coats disease. ( 26113936 )
2015
45
Intraoperative Fluorescein Angiography-Guided Treatment in Children with Early Coats' Disease. ( 25824326 )
2015
46
Bilateral Coats' Disease Combined with Retinopathy of Prematurity. ( 26413362 )
2015
47
Coats disease in a patient with Fanconi anemia: a case report. ( 25264118 )
2014
48
Combined treatment for Coats' disease: retinal laser photocoagulation combined with intravitreal bevacizumab injection was effective in two cases. ( 24666524 )
2014
49
RANIBIZUMAB IN THE MANAGEMENT OF ADVANCED COATS DISEASE STAGES 3B AND 4: Long-term Outcomes. ( 25075562 )
2014
50
Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation. ( 24876764 )
2014

Variations for Coats Disease

ClinVar genetic disease variations for Coats Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FZD4 NM_012193.3(FZD4): c.1282_1285delGACA (p.Asp428Serfs) deletion Pathogenic rs80358295 GRCh37 Chromosome 11, 86662513: 86662516
2 FZD4 NM_012193.3(FZD4): c.313A> G (p.Met105Val) single nucleotide variant Pathogenic rs80358284 GRCh38 Chromosome 11, 86952443: 86952443
3 RCBTB1 NM_018191.3(RCBTB1): c.1172+1G> A single nucleotide variant Likely pathogenic rs869312819 GRCh37 Chromosome 13, 50118872: 50118872
4 RCBTB1 NM_018191.3(RCBTB1): c.707delA (p.Asn236Thrfs) deletion Likely pathogenic rs777630688 GRCh37 Chromosome 13, 50126318: 50126318

Expression for Coats Disease

Search GEO for disease gene expression data for Coats Disease.

Pathways for Coats Disease

Pathways related to Coats Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.64 FZD4 KDR VEGFA
2 11.09 KDR VEGFA
3 11.03 KDR VEGFA
4
Show member pathways
10.94 KDR VEGFA
5 10.79 KDR VEGFA
6 10.34 KDR VEGFA
7
Show member pathways
9.83 KDR VEGFA

GO Terms for Coats Disease

Biological processes related to Coats Disease according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.67 KDR TSPAN12 VEGFA
2 positive regulation of endothelial cell migration GO:0010595 9.51 KDR VEGFA
3 positive regulation of focal adhesion assembly GO:0051894 9.48 KDR VEGFA
4 retina layer formation GO:0010842 9.46 RS1 TSPAN12
5 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 KDR VEGFA
6 eye photoreceptor cell development GO:0042462 9.4 CRB1 VEGFA
7 cell migration involved in sprouting angiogenesis GO:0002042 9.37 KDR VEGFA
8 positive regulation of positive chemotaxis GO:0050927 9.32 KDR VEGFA
9 retina vasculature morphogenesis in camera-type eye GO:0061299 9.26 FZD4 NDP
10 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.16 KDR VEGFA
11 vasculogenesis GO:0001570 9.13 FZD4 KDR VEGFA
12 extracellular matrix-cell signaling GO:0035426 8.62 FZD4 NDP

Molecular functions related to Coats Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Wnt-activated receptor activity GO:0042813 8.62 FZD4 TSPAN12

Sources for Coats Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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