MCID: CTS003
MIFTS: 58

Coats Disease

Categories: Rare diseases, Genetic diseases, Neuronal diseases, Eye diseases, Fetal diseases, Cardiovascular diseases

Aliases & Classifications for Coats Disease

MalaCards integrated aliases for Coats Disease:

Name: Coats Disease 54 12 50 24 56 52 14
Exudative Retinopathy 12 29 69
Leber Miliary Aneurysm 50 56
Retinal Telangiectasis 50 42
Congenital Retinal Telangiectasia 56
Coats' Syndrome 12
Coats' Disease 12

Characteristics:

Orphanet epidemiological data:

56
coats disease
Inheritance: Not applicable; Prevalence: <1/1000000 (United Kingdom); Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

OMIM 54 300216
Disease Ontology 12 DOID:7765
ICD10 33 H35.02 H35.07
ICD9CM 35 362.12
MeSH 42 D058456
Orphanet 56 ORPHA190
MESH via Orphanet 43 D058456
UMLS via Orphanet 70 C0154832
ICD10 via Orphanet 34 H35.0
UMLS 69 C0154832

Summaries for Coats Disease

NIH Rare Diseases : 50 coats disease is an eye disorder characterized by abnormal development of the blood vessels in the retina (retinal telangiectasia). most people begin showing symptoms in childhood. early signs and symptoms vary but may include vision loss, "crossed eyes" (strabismus), and a white mass in the pupil behind the lens of the eye (leukocoria). over time, coats disease may also lead to retinal detachment, glaucoma, and clouding of the lens of the eye (cataracts). in most cases, only one eye is affected. coats disease is not inherited and the underlying cause is not known. it has been theorized that some cases may be due to somatic mutations (acquired, not inherited) in the ndp gene. treatment depends on the symptoms present and may include cryotherapy and laser photocoagulation (alone or in combination), steroids for inflammation, and/or surgery for retinal detachment. last updated: 8/17/2017

MalaCards based summary : Coats Disease, also known as exudative retinopathy, is related to gollop coates syndrome and revesz syndrome, and has symptoms including strabismus, retinal detachment and glaucoma. An important gene associated with Coats Disease is FZD4 (Frizzled Class Receptor 4), and among its related pathways/superpathways are Proteoglycans in cancer and Cell adhesion_Plasmin signaling. The drugs Histamine and Mianserin have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and kidney, and related phenotypes are no phenotypic analysis and pigmentation

Wikipedia : 72 Coats\' disease, (also known as exudative retinitis or retinal telangiectasis, sometimes spelled... more...

Description from OMIM: 300216

Related Diseases for Coats Disease

Diseases related to Coats Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 gollop coates syndrome 11.8
2 revesz syndrome 11.8
3 idiopathic juxtafoveal retinal telangiectasia 10.9
4 idiopathic macular telangiectasia type 1 10.9
5 idiopathic macular telangiectasia type 3 10.9
6 cerebroretinal microangiopathy with calcifications and cysts 10.9
7 hypersensitivity vasculitis 10.5 FZD4 VEGFA
8 hyperostosis, endosteal 10.4 FZD4 NDP
9 leukodystrophy, hypomyelinating, 5 10.4 CRB1 VEGFA
10 respiratory syncytial virus infectious disease 10.4 NDP VEGFA
11 congenital ichthyosiform erythroderma 10.4 RS1 VEGFA
12 parietal foramina 10.4 FZD4 NDP
13 hyperaldosteronism 10.3 CRB1 VEGFA
14 kidney pelvis papillary carcinoma 10.3 KDR VEGFA
15 extragonadal germ cell cancer 10.3 KDR VEGFA
16 iliac vein thrombophlebitis 10.3 KDR VEGFA
17 vesiculobullous skin disease 10.3 KDR VEGFA
18 segmental odontomaxillary dysplasia 10.2 KDR VEGFA
19 coloboma of superior eyelid 10.2 KDR VEGFA
20 lens disease 10.2 KDR VEGFA
21 retinitis 10.2
22 factitious disorder 10.2 KDR VEGFA
23 posterior foramen magnum meningioma 10.2 KDR VEGFA
24 phlegmonous dacryocystitis 10.2 KDR VEGFA
25 benign familial neonatal epilepsy 10.2 KDR VEGFA
26 mitral valve stenosis 10.1 KDR VEGFA
27 placental choriocarcinoma 10.1 KDR VEGFA
28 diabetes mellitus, insulin-dependent, 3 10.1 KDR VEGFA
29 subdural empyema 10.1 KDR VEGFA
30 trachea carcinoma in situ 10.0 KDR VEGFA
31 renal fibrosis 10.0 KDR VEGFA
32 hidradenoma 10.0 KDR VEGFA
33 astigmatism 10.0 FZD4 NDP RS1
34 retinal detachment 9.9
35 retinoblastoma 9.9
36 ovarian hyperstimulation syndrome 9.9 KDR VEGFA
37 endotheliitis 9.9
38 muscular dystrophy 9.9
39 epileptic encephalopathy, early infantile, 1 9.8 CRB1 RS1
40 dyskeratosis congenita 9.8
41 macular holes 9.8
42 hereditary breast ovarian cancer 9.8 CRB1 NDP RS1
43 cleft lip palate dysmorphism kumar type 9.8 KDR VEGFA
44 telangiectasis 9.7
45 retinitis pigmentosa 9.7
46 cornelia de lange syndrome 9.7
47 uveitis 9.7
48 neovascular glaucoma 9.7
49 nystagmus 5, congenital, x-linked 9.6 FZD4 NDP TSPAN12
50 macular degeneration, age-related, 1 9.6 CRB1 KDR VEGFA

Graphical network of the top 20 diseases related to Coats Disease:



Diseases related to Coats Disease

Symptoms & Phenotypes for Coats Disease

Clinical features from OMIM:

300216

Human phenotypes related to Coats Disease:

56 32 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 strabismus 56 32 hallmark (90%) Very frequent (99-80%) HP:0000486
2 retinal detachment 56 32 frequent (33%) Frequent (79-30%) HP:0000541
3 glaucoma 56 32 frequent (33%) Frequent (79-30%) HP:0000501
4 cataract 56 32 occasional (7.5%) Occasional (29-5%) HP:0000518
5 abnormality of the macula 56 32 frequent (33%) Frequent (79-30%) HP:0001103
6 abnormality of the retinal vasculature 56 32 hallmark (90%) Very frequent (99-80%) HP:0008046
7 aplasia/hypoplasia of the iris 56 32 occasional (7.5%) Occasional (29-5%) HP:0008053
8 abnormality of the anterior chamber 56 32 occasional (7.5%) Occasional (29-5%) HP:0000593

MGI Mouse Phenotypes related to Coats Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.55 CTC1 FZD4 KDR NDP VEGFA
2 pigmentation MP:0001186 9.26 CRB1 FZD4 NDP RS1
3 vision/eye MP:0005391 9.17 FZD4 KDR NDP RS1 TSPAN12 VEGFA

Drugs & Therapeutics for Coats Disease

Drugs for Coats Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1043)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
2
Mianserin Approved Phase 4,Phase 3 24219-97-4 4184
3
Mirtazapine Approved Phase 4,Phase 3 85650-52-8, 61337-67-5 4205
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
6
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
9
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
12
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
13
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
14
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
15
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
16
Ethanol Approved Phase 4,Phase 2 64-17-5 702
17
Chromium Approved Phase 4,Phase 2,Phase 3,Phase 1 7440-47-3 27668
18
Dimethyl sulfoxide Approved, Vet_approved Phase 4,Phase 1 67-68-5 679
19
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757
20
Norethindrone Approved Phase 4 68-22-4 6230
21
Glatiramer Acetate Approved, Investigational Phase 4,Phase 3,Phase 2 147245-92-9 3081884
22
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
23
Povidone Approved Phase 4,Phase 3,Phase 2 9003-39-8
24 Povidone-iodine Approved Phase 4 25655-41-8
25 Trapidil Approved Phase 4 15421-84-8
26
Adefovir Dipivoxil Approved, Investigational Phase 4,Phase 2 142340-99-6 60871
27
Telbivudine Approved, Investigational Phase 4,Phase 3 3424-98-4 159269
28
Acetylcholine Approved Phase 4,Phase 3,Phase 1 51-84-3 187
29
Triclosan Approved Phase 4 3380-34-5 5564
30
Phenobarbital Approved Phase 4 50-06-6 4763
31
Thrombin Approved Phase 4,Phase 3,Phase 2
32
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
33
Ribavirin Approved Phase 4,Phase 3,Phase 2 36791-04-5 37542
34
Hyoscyamine Approved Phase 4 101-31-5 64692
35
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
36
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 1 137-58-6 3676
37
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
38
Metformin Approved Phase 4,Phase 1,Phase 2 657-24-9 14219 4091
39
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
40
Ticagrelor Approved Phase 4 274693-27-5 9871419
41
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
42
Cimetidine Approved Phase 4 51481-61-9 2756
43
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
44
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2 152923-56-3, 179045-86-4
45
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
46
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
47
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2 3056-17-5 18283
48
Glycerol Approved, Investigational Phase 4,Phase 2 56-81-5 753
49
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
50
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 55-56-1 9552079 2713

Interventional clinical trials:

(show top 50) (show all 1864)

id Name Status NCT ID Phase Drugs
1 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy Unknown status NCT00150839 Phase 4 Mirtazapine;Venlafaxine
2 Platelet Function With New Pediatric Oxygenator and Heparin and Non Heparin Coating in Pediatric Cardiac Surgery Unknown status NCT01648712 Phase 4
3 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
4 Study of the Paclitaxel-Coated Balloon Catheter in Bifurcated Coronary Lesions Unknown status NCT01278186 Phase 4
5 Non-Polymer-Based, Rapamycin-Eluting Stents to Prevent Restenosis Unknown status NCT00152308 Phase 4
6 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
7 COMPETE: A Clinical Evaluation of Chrono Carbostent Carbofilm™ Coated Stent Unknown status NCT00920283 Phase 4
8 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
9 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
10 Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia Unknown status NCT02032134 Phase 4
11 Test Efficacy of Biodegradable and Permanent Limus-Eluting Stents Unknown status NCT01068106 Phase 4
12 Treatment of Bifurcated Coronary Lesions With Cypher™-Stent Unknown status NCT00288535 Phase 4
13 Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy Unknown status NCT02264743 Phase 4 Femoston Conti;EVOREL® CONTI
14 Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease Unknown status NCT01418794 Phase 4
15 Effects of a Probiotic Supplement on Symptoms of Attention Deficit Hyperactivity Disorder and Anxiety in Children Unknown status NCT02545634 Phase 4
16 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
17 Intravascular ULTrasound Guided Versus Conventional Angiography Guided Strategy to Deploy Zotarolimus and Everolimus Eluting Third Generation Stents in the Long Coronary Artery Lesions: ULTRA-ZET Trial Unknown status NCT01979744 Phase 4
18 Effects of Copaxone in the Retinal Function in Diabetic Patients After Panphotocoagulation Unknown status NCT00677664 Phase 4 Glatiramer acetate (Copaxone);Mannitol
19 Comparison of Iodine + Isopropyl Alcohol Versus Iodine + Antimicrobial Sealant for Skin Preparation Unknown status NCT01110772 Phase 4
20 TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography Unknown status NCT01972022 Phase 4
21 Optical Coherence Tomography (OCT) Evaluation of Re-endothelization: A Comparison of the Intrepide™ Stent Versus Taxus™ Unknown status NCT00914420 Phase 4
22 Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII Unknown status NCT01918150 Phase 4
23 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
24 Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity Unknown status NCT02009540 Phase 4 Botulinum toxin injected to bladder body;Botulinum toxin injected into trigone
25 Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery Unknown status NCT01457859 Phase 4 Triclosan
26 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
27 Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PA Unknown status NCT01670474 Phase 4 rt-PA (2mg/2mL) actilysis;rt-PA
28 Telaprevir in Genotype 3 HCV Unknown status NCT02087111 Phase 4 Telaprevir;40 Kd Pegylated interferon alfa 2a;Ribavirin
29 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
30 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
31 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4 Bepreve (bepotastine ophthalmic solution) 1.5%
32 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
33 Comparison of Strut Coverage With OPTIMAX Versus SYNERGY Stents Unknown status NCT02464397 Phase 4
34 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
35 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
36 A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis Unknown status NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV steroids with oral taper
37 Efficacy of Ticagrelor vs Clopidogrel in High-risk NSTE-ACS Patients Undergoing Early PCI Unknown status NCT02201667 Phase 4 Ticagrelor;clopidogrel;Aspirin
38 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
39 Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease Completed NCT00229528 Phase 4 Paxil-CR
40 Randomized Trial Comparing Titan Stent With Zotarolimus-Eluting Stent Completed NCT00492908 Phase 4
41 Paclitaxel-coated Balloons in Femoral Indication to Defeat Restenosis Completed NCT01083030 Phase 4
42 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
43 A Bioequivalence Study of Cefadroxil Film Coated Tablets After A Single Oral Dose Administration to Healthy Subjects Completed NCT02446496 Phase 4 Cefadroxil tablets manufactured by GSK;Cefadroxil tablets manufactured by NP
44 Myfortic, Prograf, and Corticosteroids in de Novo Liver Transplantation Completed NCT01467011 Phase 4 Enteric-coated Mycophenolate Sodium
45 The Influence of Smoking Status on Prasugrel and Clopidogrel Treated Subjects Taking Aspirin and Having Stable Coronary Artery Disease Completed NCT01260584 Phase 4 Prasugrel;Clopidogrel
46 OXEMET™ 1000 mg Coated Tablets (Metformin Hydrochloride) Bioequivalence Study. OXEMET (TM) is a Trademark of the GlaxoSmithKline Group of Companies. GLAFORNIL(TM) is a Trademark of Merck. Completed NCT01842620 Phase 4 Metformin
47 Clinical Use of an Absorbable Coated Suture Material in Surgery (Safil) Completed NCT00645684 Phase 4
48 3 Limus Agent Eluting Stents With Different Polymer Coating Completed NCT00598676 Phase 4
49 Rapamycin-Eluting Stents With Different Polymer Coating to Reduce Restenosis (ISAR-TEST-3) Completed NCT00350454 Phase 4
50 The Impact of Using Triclosan-antibacterial Sutures on the Incidence of Surgical Site Infection Completed NCT01019447 Phase 4

Search NIH Clinical Center for Coats Disease

Cochrane evidence based reviews: retinal telangiectasis

Genetic Tests for Coats Disease

Genetic tests related to Coats Disease:

id Genetic test Affiliating Genes
1 Exudative Retinopathy 29
2 Coats Disease 24

Anatomical Context for Coats Disease

MalaCards organs/tissues related to Coats Disease:

39
Eye, Liver, Kidney, Skin, Testes, Bone, Heart

Publications for Coats Disease

Articles related to Coats Disease:

(show top 50) (show all 278)
id Title Authors Year
1
Coats' disease: not such a smooth ride. ( 28884344 )
2017
2
Angio-OCT findings in Coats' disease. ( 28526523 )
2017
3
Optical Coherence Tomography Angiography in Children with Leber-Coats Disease. ( 28803250 )
2017
4
Cyclophotocoagulation-induced sympathetic ophthalmia in a Coats' disease patient supported by histopathology and immunohistochemistry. ( 28820164 )
2017
5
String of Pearls: Macroaneurysms in Coats Disease. ( 28820931 )
2017
6
Serum hypercoagulability states in Coats' disease. ( 28223774 )
2017
7
Early onset coats' disease initially treated as unilateral ROP at 39A weeks postmenstrual age: a case report. ( 28814287 )
2017
8
Coats' disease with retinochoroidal anastomosis. ( 28757699 )
2017
9
Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience. ( 28461016 )
2017
10
Optical Coherence Tomography and Optical Coherence Tomography Angiography in Monitoring Coats' Disease. ( 28377823 )
2017
11
Refining Coats' disease by ultra-widefield imaging and optical coherence tomography angiography. ( 28875282 )
2017
12
LONG-TERM ANATOMICAL AND FUNCTIONAL OUTCOMES FOLLOWING VITRECTOMY FOR ADVANCED COATS DISEASE. ( 27984550 )
2016
13
Uveal Melanoma Mimicking Advanced Coats' Disease in a Young Patient. ( 27239453 )
2016
14
iTRAQ-Based Proteomics Investigation of Aqueous Humor from Patients with Coats' Disease. ( 27416065 )
2016
15
Risk of Tractional Retinal Detachment Following Intravitreal Bevacizumab Along with Subretinal Fluid Drainage and Cryotherapy for Stage 3B Coats' Disease. ( 27162454 )
2016
16
Haploinsufficiency of RCBTB1 is associated with Coats disease and familial exudative vitreoretinopathy. ( 26908610 )
2016
17
Teaching NeuroImages: Coats disease revealing facioscapulohumeral muscular dystrophy. ( 27462044 )
2016
18
"Mommy... I Can't See With My Eye". Coats disease with foveal exudation (Stage 2b). ( 27018878 )
2016
19
Coats' disease of adult-onset in 48 eyes. ( 27609165 )
2016
20
Intravitreal bevacizumab injections combined with laser photocoagulation for adult-onset Coats' disease. ( 27270347 )
2016
21
Optical Coherence Tomography Angiography Findings in Coats' Disease. ( 27434894 )
2016
22
Differences in aqueous concentrations of cytokines in paediatric and adult patients with Coats' disease. ( 27364629 )
2016
23
EXTRAMACULAR FIBROSIS IN COATS' DISEASE. ( 26991649 )
2016
24
Subretinal Fluid Drainage and Vitrectomy Are Helpful in Diagnosing and Treating Eyes with Advanced Coats' Disease. ( 27462247 )
2016
25
A Case of Anterior Chamber Cholesterolosis Due to Coats' Disease and a Review of Reported Cases. ( 27014384 )
2016
26
Retinoblastoma versus advanced Coats' disease: Is enucleation the answer? ( 27435805 )
2016
27
INTRAVITREAL RANIBIZUMAB AS AN ADJUNCTIVE TREATMENT FOR COATS DISEASE (6-YEAR FOLLOW-UP). ( 27472513 )
2016
28
Successful use of intravitreal ranibizumab injection and combined treatment in the management of Coats' disease. ( 27150442 )
2016
29
Optical Coherence Tomography Angiography Findings in Coats' Disease. ( 27549879 )
2016
30
SUBFOVEAL NODULE IN COATS' DISEASE: Toward an Updated Classification Predicting Visual Prognosis. ( 28030429 )
2016
31
Coats' Disease: Very Long-Term Outcome After Early Stage Conventional Treatment. ( 27014383 )
2016
32
Ultra-wide field imaging in the diagnosis and management of adult-onset Coats' disease. ( 27476647 )
2016
33
Treatment of Coats' Disease With Combination Therapy of Intravitreal Bevacizumab, Laser Photocoagulation, and Sub-Tenon Corticosteroids. ( 27183548 )
2016
34
A Case of Coats Disease and Concurrent Anisometropic Amblyopia. ( 28090595 )
2016
35
Coats' disease and retrobulbar haemodynamics. ( 26686879 )
2016
36
Intravitreal Bevacizumab as an adjunct to laser in the management of adult onset Coats' disease. ( 27234923 )
2016
37
Evaluation of Follow-Up and Treatment Results in Coats' Disease. ( 28058165 )
2016
38
Coats' disease with macular oedema responsive to aflibercept and argon laser. ( 28038924 )
2016
39
Anesthetic Management of an Unusual Case of Coats' Disease Complex: Use of Dexmedetomidine. ( 26237668 )
2015
40
Pearls and pitfalls in diagnosis and management of coats disease. ( 25811949 )
2015
41
A 6-year-old boy with Cornelia de Lange syndrome and Coats disease: case report and review of the literature. ( 26486036 )
2015
42
CLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF COATS DISEASE IN A SAUDI ARABIAN POPULATION. ( 25978728 )
2015
43
A Case of Congenital Simple Hamartoma of the Retinal Pigment Epithelium and Coats' Disease in the Same Eye. ( 26240514 )
2015
44
Intraoperative Fluorescein Angiography-Guided Treatment in Children with Early Coats' Disease. ( 25824326 )
2015
45
Multiple Arterial Macroaneurysms in Acquired Coats' Disease in an Adult - A Case Report. ( 25902131 )
2015
46
577-NM YELLOW LASER PHOTOCOAGULATION FOR COATS DISEASE. ( 26579790 )
2015
47
Coats disease. ( 26113936 )
2015
48
An interesting case of Coats' disease. ( 26663970 )
2015
49
Bilateral Coats' Disease Combined with Retinopathy of Prematurity. ( 26413362 )
2015
50
Intravitreal bevacizumab injections combined with laser photocoagulation for adult-onset Coats' disease. ( 26631136 )
2015

Variations for Coats Disease

ClinVar genetic disease variations for Coats Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FZD4 NM_012193.3(FZD4): c.1282_1285delGACA (p.Asp428Serfs) deletion Pathogenic rs80358295 GRCh37 Chromosome 11, 86662513: 86662516
2 FZD4 NM_012193.3(FZD4): c.313A> G (p.Met105Val) single nucleotide variant Pathogenic rs80358284 GRCh38 Chromosome 11, 86952443: 86952443
3 RCBTB1 NM_018191.3(RCBTB1): c.1172+1G> A single nucleotide variant Likely pathogenic rs869312819 GRCh37 Chromosome 13, 50118872: 50118872
4 RCBTB1 NM_018191.3(RCBTB1): c.707delA (p.Asn236Thrfs) deletion Likely pathogenic rs777630688 GRCh37 Chromosome 13, 50126318: 50126318

Expression for Coats Disease

Search GEO for disease gene expression data for Coats Disease.

Pathways for Coats Disease

Pathways related to Coats Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.44 FZD4 KDR VEGFA
2 11.06 KDR VEGFA
3 10.98 KDR VEGFA
4
Show member pathways
10.88 KDR VEGFA
5 10.69 KDR VEGFA
6 10 KDR VEGFA

GO Terms for Coats Disease

Biological processes related to Coats Disease according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.67 KDR TSPAN12 VEGFA
2 positive regulation of endothelial cell migration GO:0010595 9.51 KDR VEGFA
3 positive regulation of focal adhesion assembly GO:0051894 9.48 KDR VEGFA
4 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.46 KDR VEGFA
5 retina layer formation GO:0010842 9.43 RS1 TSPAN12
6 eye photoreceptor cell development GO:0042462 9.4 CRB1 VEGFA
7 cell migration involved in sprouting angiogenesis GO:0002042 9.37 KDR VEGFA
8 positive regulation of positive chemotaxis GO:0050927 9.32 KDR VEGFA
9 retina vasculature morphogenesis in camera-type eye GO:0061299 9.26 FZD4 NDP
10 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.16 KDR VEGFA
11 vasculogenesis GO:0001570 9.13 FZD4 KDR VEGFA
12 extracellular matrix-cell signaling GO:0035426 8.62 FZD4 NDP

Molecular functions related to Coats Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Wnt-activated receptor activity GO:0042813 8.62 FZD4 TSPAN12

Sources for Coats Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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51 NINDS
52 Novoseek
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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