MCID: CCN002
MIFTS: 50

Cocaine Abuse malady

Mental diseases category
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Summaries for Cocaine Abuse

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Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A substance abuse that involves the recurring use of cocaine despite negative consequences.

MalaCards: Cocaine Abuse is related to ischemia and alcohol dependence. An important gene associated with Cocaine Abuse is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Monoamine Transport and Amphetamine addiction. The compounds ibzm and octopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, uterus and placenta, and related mouse phenotypes are mortality/aging and endocrine/exocrine gland.

Aliases & Classifications for Cocaine Abuse

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

cocaine abuse 8 10 45 62


External Ids:

Disease Ontology8 DOID:809
MeSH35 D019970
SNOMED-CT58 78267003
ICD9CM27 305.60, 305.6

Related Diseases for Cocaine Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cocaine Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.6SLC6A3, OPRK1, DRD2
2alcohol dependence30.6OPRK1, DRD2
3attention deficit hyperactivity disorder30.5SLC6A3, DRD2, DBH
4neuroleptic malignant syndrome30.5DRD2
5personality disorder30.4SLC6A3, DRD2
6substance abuse30.4DRD2, SLC6A3
7cocaine dependence30.3SLC6A3, OPRK1, DRD2, DBH
8dementia30.2HTR3A, BCHE, OPRK1, SLC6A3
9schizophrenia30.2DBH, HTR3A, BCHE, DRD2, OPRK1, SLC6A3
10antisocial personality disorder30.2SLC6A3, DRD2
11alcohol abuse30.2SLC6A3, DRD2
12hyperprolactinemia30.2DBH, DRD2
13bipolar disorder30.2HTR3A, DRD2
14pheochromocytoma30.1SLC6A3, DRD2, DBH
15drug dependence30.1SLC6A3, OPRK1, DRD2
16drug addiction30.1DRD2, OPRK1, SLC6A3
17obesity30.1SLC6A3, DRD2, BCHE
18migraine30.1DBH, HTR3A, DRD2, SLC6A3
19cerebritis10.5
20myocardial infarction10.4
21vasculitis10.4
22blindness10.4
23neuronitis10.3
24acute myocardial infarction10.3
25dilated cardiomyopathy10.3
26aneurysm10.3
27priapism10.2
28placental abruption10.2
29wegener's granulomatosis10.2
30atherosclerosis10.2
31cellulitis10.2
32esophagitis10.2
33keratitis10.2
34pancreatitis10.2
35thrombocytopenia10.2
36sickle cell disease10.2
37venous thrombosis10.2
38oppositional defiant disorder10.1SLC6A3
39burns10.1
40coronary artery disease10.1
41wolff-parkinson-white syndrome10.1
42antiphospholipid syndrome10.1
43acute pancreatitis10.1
44intracranial aneurysm10.1
45pharyngitis10.1
46pemphigus10.1
47cleft lip10.1
48panic disorder10.1
49aortitis10.1
50acquired immunodeficiency syndrome10.1

Graphical network of the top 20 diseases related to Cocaine Abuse:



Diseases related to cocaine abuse

Symptoms for Cocaine Abuse

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Drugs & Therapeutics for Cocaine Abuse

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cocaine Abuse

Search NIH Clinical Center for Cocaine Abuse

Genetic Tests for Cocaine Abuse

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Anatomical Context for Cocaine Abuse

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Sources:
33MalaCards
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MalaCards organs/tissues related to Cocaine Abuse:

33
Brain, Uterus, Placenta, Testes, Lung, Pituitary, Thalamus, Amygdala, Cortex, Skin, Heart, Prefrontal cortex

Animal Models for Cocaine Abuse or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cocaine Abuse:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.9SLC6A3, DRD2, BCHE, HTR3A, DBH
2MP:00053797.8SLC6A3, OPRK1, DRD2, HTR3A, DBH
3MP:00107717.7DBH, HTR3A, DRD2, OPRK1, SLC6A3
4MP:00053767.6DBH, HTR3A, BCHE, DRD2, SLC6A3
5MP:00053897.6SLC6A3, OPRK1, DRD2, BCHE, HTR3A
6MP:00053867.5DBH, HTR3A, DRD2, OPRK1, SLC6A3

Publications for Cocaine Abuse

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Sources:
52PubMed
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Articles related to Cocaine Abuse:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Levamisole-induced occlusive necrotising vasculitis in cocaine abusers: an unusual cause of skin necrosis and neutropenia. (22716045)
2013
2
The impact of contingency management on quality of life among cocaine abusers with and without alcohol dependence. (22211346)
2012
3
Association between cocaine abuse in pregnancy and placenta-associated syndromes using propensity score matching approach. (21975278)
2012
4
Sex hormones: a new treatment for cocaine abuse? (21918518)
2011
5
Cocaine abuse among patients: a study at the Charleston Area Medical Center. (21932758)
2010
6
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
7
Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuse. (17170312)
2007
8
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. (17715210)
2007
9
Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse. (16584128)
2006
10
Severe destructive sinusitis and orbital apex syndrome as a complication of intranasal cocaine abuse. (16787814)
2006
11
Rhabdomyolysis of the left upper leg after cocaine abuse. (16883771)
2006
12
Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum. (16110277)
2005
13
Pharmacotherapy and other treatments for cocaine abuse and dependence. (16639150)
2005
14
Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. (12684441)
2003
15
Olanzapine treatment for patients with schizophrenia and cocaine abuse. (12530415)
2002
16
Commentary on auricular acupuncture for cocaine abuse. (12013511)
2002
17
The effects of maternal cocaine abuse on mothers and newborns. (11123004)
2000
18
The role of weight control as a motivation for cocaine abuse. (9573424)
1998
19
Can cocaine abuse cause parkinsonism? (9134080)
1997
20
A randomized double-blind study of carbamazepine in the treatment of cocaine abuse. (9246023)
1997
21
Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. (9372557)
1997
22
Brief coping skills treatment for cocaine abuse: substance use outcomes at three months. (9581004)
1997
23
Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients. (8841686)
1996
24
Intracranial hemorrhage associated with cocaine abuse: a prospective autopsy study. (8628469)
1996
25
Nasal cocaine abuse mimicking midline granuloma. (7829720)
1995
26
The prevalence of cocaine abuse during pregnancy in Barcelona. (7821487)
1994
27
Comparative cocaine abuse treatment strategies: enhancing client retention and treatment exposure. (7734463)
1994
28
Priapism associated with chronic cocaine abuse. (8042894)
1994
29
Cocaine abuse in methadone maintenance programs: integrating pharmacotherapy with psychosocial interventions. (7931858)
1994
30
Index of suspicion. Case 1. Diagnosis: cocaine abuse. (8247971)
1993
31
The antecedents of women's crack cocaine abuse: family substance abuse, sexual abuse, depression and illicit drug use. (8246316)
1993
32
Neonatal intestinal ischemia with bowel perforation: an in utero complication of maternal cocaine abuse. (1590129)
1992
33
Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics. (1317046)
1992
34
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
35
Central nervous system infarction related to cocaine abuse. (1926246)
1991
36
Cocaine abuse by medical students. (1985598)
1991
37
Plasma prolactin levels and cocaine abuse. (1992852)
1991
38
Pharmacologic treatment of cocaine abuse. (1949942)
1991
39
Deep venous thrombosis in intravenous cocaine abuse mimicking septic arthritis of the shoulder. (1990471)
1991
40
Cocaine abuse in maternal-child health care. (2172440)
1990
41
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
42
Effects of maternal cocaine abuse on perinatal and infant outcome. (2338984)
1990
43
Priapism associated with intranasal cocaine abuse. (2304177)
1990
44
Rhabdomyolysis and acute renal failure associated with cocaine abuse. (2231831)
1990
45
Panic disorder and cocaine abuse in alcoholics. (2211546)
1990
46
Presidential address of the SSCI. Metabolic and social consequences of cocaine abuse. (2356849)
1990
47
Unrecognized left ventricular dysfunction in an apparently healthy cocaine abuse population. (2347124)
1990
48
Cocaine abuse during pregnancy: correlation between prenatal care and perinatal outcome. (2586952)
1989
49
Cocaine abuse: what every emergency nurse should know. (2668596)
1989
50
Placental abruption associated with cocaine abuse. (3285653)
1988

Variations for Cocaine Abuse

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Expression for genes affiliated with Cocaine Abuse

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Abuse

Search GEO for disease gene expression data for Cocaine Abuse.

Pathways for genes affiliated with Cocaine Abuse

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Cocaine Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity38
9.6SLC6A3, DBH
2
Show member pathways
9.5SLC6A3, DRD2
3
Show member pathways
8.9SLC6A3, DRD2, HTR3A

Compounds for genes affiliated with Cocaine Abuse

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Cocaine Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1ibzm459.8SLC6A3, DRD2
2octopamine45 2910.8DBH, SLC6A3
3tetrabenazine45 29 61 51 1113.7SLC6A3, DRD2
4tiapride459.7BCHE, DRD2
5alizapride45 1110.7DRD2, HTR3A
6d amphetamine459.7SLC6A3, DRD2
7ipecac459.7HTR3A, BCHE
8droperidol45 1110.6HTR3A, DRD2
9amperozide459.6DRD2, HTR3A
10ephedrine45 29 1111.5SLC6A3, BCHE
11alpha-methyl-p-tyrosine459.5DBH, SLC6A3, DRD2
12maoa459.5SLC6A3, DRD2, DBH
13tyramine45 29 2411.5DBH, BCHE, SLC6A3
146-hydroxydopamine459.4DRD2, SLC6A3, DBH
15sulpiride45 29 1111.4SLC6A3, DRD2, BCHE
16mptp459.4DBH, DRD2, SLC6A3
17remifentanil45 1110.4OPRK1, BCHE
18benzamide3 4510.4HTR3A, DRD2
19procaine45 29 1111.3SLC6A3, BCHE, HTR3A
20granisetron51 45 1111.3HTR3A, DRD2
21imipramine45 29 51 24 1113.3SLC6A3, HTR3A, DBH
22hallucinogen459.3OPRK1, HTR3A
23carbidopa45 2910.3SLC6A3, DBH
24quetiapine45 51 29 24 1113.3DRD2, SLC6A3, HTR3A
25risperidone45 51 29 61 24 1114.3DRD2, SLC6A3, HTR3A
26metoclopramide45 51 1111.3HTR3A, DBH, DRD2
27fluoxetine45 51 29 1112.3SLC6A3, DRD2, HTR3A
28olanzapine45 51 29 24 1113.2SLC6A3, HTR3A, DRD2
29chlorpromazine29 45 51 1112.2DRD2, HTR3A, BCHE
30haloperidol45 51 29 3 1113.1HTR3A, DRD2, SLC6A3
31amphetamine45 51 1111.1DRD2, SLC6A3, OPRK1
32ibogaine459.1HTR3A, OPRK1, SLC6A3
33choline45 24 1111.0DBH, SLC6A3, BCHE
345-hydroxytryptamine458.9DBH, HTR3A, DRD2, SLC6A3
35lead458.9BCHE, OPRK1, DBH
36opiate458.7SLC6A3, DRD2, DBH, OPRK1
37levodopa45 119.7OPRK1, SLC6A3, DBH, DRD2
38morphine45 51 29 1111.7OPRK1, SLC6A3, DRD2, DBH
39heroin45 51 1110.6OPRK1, SLC6A3, DRD2, BCHE
40nmda45 299.6DRD2, OPRK1, SLC6A3, BCHE
41amitriptyline45 29 51 1111.5HTR3A, OPRK1, SLC6A3, BCHE
42clozapine45 29 51 1111.5OPRK1, DRD2, SLC6A3, HTR3A
43amine458.5DBH, BCHE, OPRK1, HTR3A
44cocaine45 119.2BCHE, DBH, DRD2, OPRK1, SLC6A3
45nicotine45 29 51 1111.2SLC6A3, OPRK1, DRD2, DBH, BCHE
46glutamate458.1OPRK1, DRD2, BCHE, DBH, SLC6A3
47gaba458.1OPRK1, SLC6A3, HTR3A, DRD2, DBH
48dopamine45 29 24 1111.1HTR3A, SLC6A3, OPRK1, DRD2, DBH
49norepinephrine45 24 119.6HTR3A, OPRK1, DRD2, BCHE, DBH, SLC6A3
50acetylcholine45 51 29 24 1111.6SLC6A3, DBH, BCHE, DRD2, OPRK1, HTR3A

GO Terms for genes affiliated with Cocaine Abuse

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16Gene Ontology
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Cellular components related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.6SLC6A3, DRD2, HTR3A
2integral component of plasma membraneGO:0058878.1SLC6A3, OPRK1, DRD2, HTR3A

Biological processes related to Cocaine Abuse according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.9SLC6A3, DBH
2adenohypophysis developmentGO:0219849.8SLC6A3, DRD2
3response to iron ionGO:0100399.7DRD2, SLC6A3
4prepulse inhibitionGO:0601349.7SLC6A3, DRD2
5behavioral response to ethanolGO:0481499.7DRD2, DBH
6response to nicotineGO:0350949.7SLC6A3, DRD2
7response to amphetamineGO:0019759.6DBH, DRD2
8positive regulation of multicellular organism growthGO:0400189.5SLC6A3, DRD2
9response to ethanolGO:0454719.4SLC6A3, HTR3A
10visual learningGO:0085429.4DBH, DRD2
11sensory perception of smellGO:0076089.2SLC6A3, DRD2
12response to cocaineGO:0422209.2SLC6A3, DRD2, HTR3A
13response to drugGO:0424939.1BCHE, DRD2, SLC6A3
14locomotory behaviorGO:0076268.6SLC6A3, OPRK1, DRD2, DBH
15synaptic transmissionGO:0072688.4DBH, HTR3A, OPRK1, SLC6A3

Molecular functions related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catalytic activityGO:0038249.5BCHE, DBH
2dopamine bindingGO:0352409.4SLC6A3, DRD2
3drug bindingGO:0081449.2SLC6A3, DRD2

Products for genes affiliated with Cocaine Abuse

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Sources for Cocaine Abuse

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet