MCID: CCN002
MIFTS: 52

Cocaine Abuse malady

Summaries for Cocaine Abuse

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A substance abuse that involves the recurring use of cocaine despite negative consequences.

MalaCards: Cocaine Abuse is related to alcohol abuse and cocaine dependence. An important gene associated with Cocaine Abuse is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Selected targets of CREB1. The compounds gbr 12909 and nisoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Cocaine Abuse

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

cocaine abuse 8 10 45 61


External Ids:

Disease Ontology8 DOID:809
MeSH35 D019970
SNOMED-CT57 78267003
ICD9CM27 305.6, 305.60

Related Diseases for Cocaine Abuse

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cocaine Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.1SLC6A4, SLC6A3, DRD2
2cocaine dependence31.0SLC18A2, SLC6A4, SLC6A3, PDYN, DRD2, OPRK1
3substance abuse30.6DRD2, SLC6A3, SLC6A4
4alcohol dependence30.5SLC6A4, OPRK1, DRD2
5attention deficit hyperactivity disorder30.5DRD2, DBH, SLC6A3, SLC6A4, SLC6A2
6neuroleptic malignant syndrome30.3DRD2
7heroin dependence30.1DRD2
8bipolar disorder30.1HTR3A, DRD2, SLC6A4
9antisocial personality disorder30.1DRD2, SLC6A3, SLC6A4
10panic disorder30.1SLC6A4, HTR3A
11drug addiction30.1PDYN, DRD2, OPRK1, SLC6A3, SLC18A2
12pheochromocytoma30.1PDYN, DRD2, DBH, SLC6A3, SLC6A2, SLC18A2
13opioid abuse10.5
14vasculitis10.4
15acute myocardial infarction10.3
16orbital cellulitis10.2
17cellulitis10.2
18cannabis abuse10.2
19priapism10.2
20placental abruption10.2
21n syndrome10.2
22atherosclerosis10.2
23thrombocytopenia10.2
24sickle cell disease10.2
25venous thrombosis10.2
26burns10.1
27coronary artery disease,10.1
28acute pancreatitis10.1
29antiphospholipid syndrome10.1
30wolff-parkinson-white syndrome10.1
31renal agenesis10.1
32coronary aneurysm10.1
33wound botulism10.1
34hyperprolactinemia10.1
35dependent personality disorder10.1
36intracranial aneurysm10.1
37aortitis10.1
38pemphigus10.1
39gastric ulcer10.1
40poland syndrome10.1
41cleft palate10.1
42amphetamine abuse10.1
43acquired immunodeficiency syndrome10.1
44brown-sequard syndrome10.1
45coronary thrombosis10.1
46malignant hyperthermia10.1
47mutism10.1
48septic arthritis10.1
49adult syndrome10.1
50inferior myocardial infarction10.1

Graphical network of the top 20 diseases related to Cocaine Abuse:



Diseases related to cocaine abuse

Clinical Features for Cocaine Abuse

Drugs & Therapeutics for Cocaine Abuse

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cocaine Abuse

Drug clinical trials:

Search ClinicalTrials for Cocaine Abuse

Search NIH Clinical Center for Cocaine Abuse

Search CenterWatch for Cocaine Abuse

Genetic Tests for Cocaine Abuse

Anatomical Context for Cocaine Abuse

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cocaine Abuse:

33
Brain, Cortex, Heart, Lung, Skin, Uterus, Placenta, Fetal brain, Prefrontal cortex, Cingulate cortex, Thalamus, Amygdala, Fetal lung, Adrenal cortex, Pituitary

Animal Models for Cocaine Abuse or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cocaine Abuse

Sources:
51PubMed
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Articles related to Cocaine Abuse:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
The impact of contingency management on quality of life among cocaine abusers with and without alcohol dependence. (22211346)
2012
2
Association between cocaine abuse in pregnancy and placenta-associated syndromes using propensity score matching approach. (21975278)
2012
3
Prosthetic and surgical management of oronasal communications secondary to cocaine abuse. (22474793)
2012
4
Oral manifestation upon short time cocaine abuse. A case report. (22669060)
2012
5
Multifocal inflammatory leukoencephalopathy associated with cocaine abuse: is levamisole responsible? (22702903)
2012
6
Lesson of the month (1). Ictal asystole due to unsuspected cocaine abuse. (21526711)
2011
7
Posterior ischaemic myelopathy associated with cocaine abuse. (21038543)
2010
8
Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study. (20307798)
2010
9
Atomoxetine Treatment for Cocaine Abuse and Adult Attention-Deficit Hyperactivity Disorder (ADHD): A Preliminary Open Trial. (19430599)
2009
10
Optic neuropathy caused by naso-orbital mass in chronic intranasal cocaine abuse. (19458577)
2009
11
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. (17715210)
2007
12
Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse. (16584128)
2006
13
Significance of cocaine abuse in the past. (16672097)
2006
14
Recurrent intestinal obstruction in a cocaine abuser. (15700151)
2006
15
A circular structure in the aortic outflow tract during diastole: an unusual complication of cocaine abuse. (16750754)
2006
16
PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. (16055768)
2005
17
The role of the dopamine transporter in cocaine abuse. (15545021)
2004
18
Acute basilar artery occlusion treated by thromboaspiration in a cocaine and ecstasy abuser. (14504335)
2003
19
Midline palate perforation from cocaine abuse. (12960878)
2003
20
Olanzapine treatment for patients with schizophrenia and cocaine abuse. (12530415)
2002
21
Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. (11959923)
2002
22
Pathophysiology of cocaine abuse. (12094914)
2002
23
Synthesis and pharmacology of site specific cocaine abuse treatment agents: a new synthetic methodology for methylphenidate analogs based on the Blaise reaction. (11461755)
2001
24
Platelet activation as a universal trigger in the pathogenesis of acute coronary events after cocaine abuse. (11683077)
2001
25
Cocaine abuse and coronary artery dissection. (11216774)
2001
26
Cocaine abuse, generalized myasthenia, complete external ophthalmoplegia, and pseudotonic pupil. (11262695)
2001
27
Chronic inhaled cocaine abuse may predispose to the development of pancreatic adenocarcinoma. (10612544)
1999
28
Psychosocial treatments for cocaine dependence: National Institute on Drug Abuse Collaborative Cocaine Treatment Study. (10359461)
1999
29
Severe avascular necrosis of the nasal chambers secondary to cocaine abuse. (10604166)
1999
30
Microbial keratitis following cocaine abuse in a soft contact lens wearer. (10450397)
1999
31
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. (9892293)
1999
32
Validation of the criteria for DSM diagnosis of cocaine abuse and cocaine dependence. (9513636)
1998
33
Brief coping skills treatment for cocaine abuse: substance use outcomes at three months. (9581004)
1997
34
Psychopharmacologic violence associated with cocaine abuse: kindling of a limbic dyscontrol syndrome? (9004337)
1996
35
Cocaine abuse in pregnancy: its evaluation through hair analysis of pathological new-borns. (8950288)
1996
36
Anesthetic management of the cocaine abuse patient. (7502643)
1995
37
Transient monocular blindness associated with cocaine abuse. (8423897)
1993
38
How cocaine abuse affects post-extraction bleeding. (8277059)
1993
39
Cocaine abuse. (8323092)
1993
40
Cocaine abuse in a high risk obstetrical population. (8468153)
1993
41
Conditioned responses to cocaine-related stimuli in cocaine abuse patients. (1603895)
1992
42
Methadone dose for cocaine abuse. (1883015)
1991
43
A review of the literature on cocaine abuse in pregnancy. (2003076)
1991
44
Cardiovascular effects of cocaine abuse. (1931262)
1991
45
Bupropion reduces cocaine abuse in methadone-maintained patients. (1898631)
1991
46
Effects of maternal cocaine abuse on perinatal and infant outcome. (2338984)
1990
47
Cocaine abuse and dependence. (2193362)
1990
48
Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse. (3441016)
1987
49
Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine. (3514688)
1986
50
Wound botulism associated with parenteral cocaine abuse--New York City. (6801464)
1982

Genetic Variations for Cocaine Abuse

Expression for genes affiliated with Cocaine Abuse

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cocaine Abuse

Search GEO for disease gene expression data for Cocaine Abuse.

Pathways for genes affiliated with Cocaine Abuse

Sources:
50PharmGKB, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Cocaine Abuse

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Cocaine Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1gbr 129094510.3SLC6A2, SLC6A3, SLC6A4, SLC18A2
2nisoxetine45 2911.3SLC18A2, SLC6A2, SLC6A4, SLC6A3
3tropane4510.3SLC18A2, SLC6A2, SLC6A4, SLC6A3
4d amphetamine4510.2SLC6A2, SLC6A4, SLC6A3, DRD2
5maoa4510.2SLC6A2, SLC6A4, DBH, SLC6A3, DRD2
6mazindol45 29 1112.2SLC6A3, SLC6A4, SLC6A2, SLC18A2
73,4-Methylenedioxymethamphetamine1110.2SLC6A4, SLC6A3, SLC6A2, SLC18A2
8milnacipran45 50 1112.2SLC18A2, SLC6A2, SLC6A3, SLC6A4
9tyramine45 29 2412.2SLC6A2, SLC6A4, SLC6A3, DBH, BCHE
10MMDA1110.2SLC6A3, SLC18A2, SLC6A2, SLC6A4
11methylphenidate45 50 1112.2SLC6A4, SLC18A2, SLC6A2, SLC6A3, DRD2
12Tapentadol1110.2HTR3A, SLC6A2, SLC6A4, OPRK1
13reboxetine45 29 1112.2SLC6A3, SLC6A4, SLC18A2, SLC6A2
14heroin45 50 1112.1PDYN, SLC6A3, DRD2, OPRK1, SLC6A4, BCHE
15duloxetine45 50 29 1113.1SLC6A4, SLC6A3, SLC18A2, SLC6A2
16ephedrine29 45 1112.1SLC6A3, SLC6A2, SLC18A2, BCHE
17venlafaxine50 45 11 2413.1SLC18A2, SLC6A2, SLC6A4, SLC6A3, HTR3A
18amitriptyline45 50 29 1113.1OPRK1, SLC6A2, SLC6A4, HTR3A, SLC6A3, BCHE
19opiate4510.1SLC6A3, DBH, OPRK1, PDYN, DRD2, SLC6A4
20bupropion45 50 11 2413.1SLC6A3, SLC18A2, SLC6A2, SLC6A4, DRD2
216-hydroxydopamine4510.1PDYN, SLC6A3, NR4A2, DBH, SLC6A2, DRD2
22indole4510.1HTR3A, OPRK1, SIGMAR1, SLC6A4, SLC18A2
23mdma4510.1SLC6A3, SLC18A2, SLC6A2, SLC6A4
24Ephedra1110.1SLC6A2, SLC6A3, SLC18A2, SLC6A4
25maprotiline45 1111.1SLC6A4, SLC6A2, HTR3A, SLC6A3
26paroxetine45 50 29 1113.1SLC6A3, SLC6A4, HTR3A, SLC18A2, SLC6A2
27fluoxetine50 45 29 1113.0SLC6A3, SLC18A2, SLC6A2, SLC6A4, DRD2, HTR3A
28escitalopram45 50 11 2413.0SLC6A3, SLC18A2, SLC6A4, SLC6A2
29mptp4510.0SLC6A4, DRD2, SLC18A2, SLC6A2, SLC6A3, DBH
30nmda45 2911.0SLC6A3, OPRK1, PDYN, BCHE
31methamphetamine45 50 1112.0SLC6A3, DRD2, SLC6A2, SLC18A2, SLC6A4, PDYN
32imipramine45 50 29 11 2414.0DBH, SLC6A3, SLC6A4, SLC6A2, SLC18A2, HTR3A
33spec-t4510.0DRD2, SLC18A2, SLC6A4, SLC6A2, SLC6A3
34levodopa45 1111.0PDYN, DRD2, DBH, SLC6A3, SLC18A2, OPRK1
35nefazodone45 50 1111.9SLC6A4, SLC6A2, SLC6A3, HTR3A
36amine459.9SLC6A2, BCHE, SLC18A2, SLC6A4, DBH, OPRK1
375-hydroxytryptamine459.9SLC18A2, SLC6A2, SLC6A4, DBH, HTR3A, SLC6A3
38haloperidol45 29 2 50 1113.9SLC18A2, SLC6A2, SLC6A4, SLC6A3, DRD2, HTR3A
39citalopram50 45 11 2412.9SLC18A2, HTR3A, SLC6A2, SLC6A3, SLC6A4
40reserpine45 29 1111.9DRD2, SLC6A3, SLC6A2, SLC18A2
41trimipramine50 45 1111.9DRD2, SLC6A2, SLC6A4, SLC6A3
42amphetamine45 1110.8SLC18A2, SLC6A2, SLC6A4, SLC6A3, OPRK1, PDYN
43sulpiride45 29 1111.7BCHE, SLC6A3, DRD2, PDYN
44nicotine45 50 29 1112.6SLC6A2, DBH, SLC18A2, BCHE, SLC6A4, OPRK1
45glutamate459.4BCHE, SLC18A2, SLC6A2, SLC6A4, DBH, SLC6A3
46gaba459.4SLC6A3, SLC6A4, SLC6A2, SLC18A2, PLP1, DBH
47acetylcholine45 50 29 11 2413.4PDYN, HTR3A, DRD2, OPRK1, DBH, PLP1
48norepinephrine45 11 2411.4PDYN, HTR3A, DRD2, OPRK1, NR4A2, DBH
49dopamine45 29 11 2412.2SLC18A2, CARTPT, PDYN, HTR3A, DRD2, OPRK1
50cocaine45 1110.1PDYN, DRD2, OPRK1, DBH, BCHE, SLC18A2

GO Terms for genes affiliated with Cocaine Abuse

Sources:
16Gene Ontology
See all sources

Cellular components related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.9SLC18A2, SLC6A3, SNCB, HTR3A
2integral to plasma membraneGO:0058879.0SLC18A2, HTR3A, DRD2, OPRK1, SIGMAR1, SLC6A3

Biological processes related to Cocaine Abuse according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.5SLC6A3, DBH
2adenohypophysis developmentGO:02198410.5SLC6A3, DRD2
3behavioral response to ethanolGO:04814910.4DRD2, DBH
4axon ensheathmentGO:00836610.4PLP1, CLDN11
5deathGO:01626510.4NR4A2, SLC18A2
6regulation of dopamine metabolic processGO:04205310.4NR4A2, SLC6A3
7dopamine biosynthetic processGO:04241610.3SLC6A3, NR4A2
8dopamine metabolic processGO:04241710.3SNCB, DRD2
9response to iron ionGO:01003910.3DRD2, SLC6A3
10response to cocaineGO:04222010.2HTR3A, DRD2, SLC6A3, SLC18A2
11response to painGO:04826510.2SLC6A2, DBH
12cell deathGO:00821910.2PDYN, SIGMAR1, PLP1, SLC6A3
13response to amphetamineGO:00197510.2SLC18A2, DBH, NR4A2, DRD2
14monoamine transportGO:01584410.2SLC6A3, SLC6A4, SLC6A2, SLC18A2
15prepulse inhibitionGO:06013410.2SLC6A3, DRD2
16locomotory behaviorGO:00762610.1DRD2, OPRK1, DBH, SLC6A3, SLC18A2
17circadian regulation of gene expressionGO:0329229.9DRD2, CARTPT
18synaptic transmissionGO:0072689.4SLC18A2, CARTPT, PDYN, HTR3A, OPRK1, SNCB

Molecular functions related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.3SLC6A3, DRD2
2serotonin transmembrane transporter activityGO:01522210.1SLC6A4, SLC18A2
3structural constituent of myelin sheathGO:01991110.1PLP1, MOBP
4monoamine transmembrane transporter activityGO:00850410.0SLC18A2, SLC6A2, SLC6A4, SLC6A3
5drug bindingGO:00814410.0SLC18A2, SLC6A3, SIGMAR1, DRD2
6opioid receptor activityGO:0049859.9SIGMAR1, OPRK1

Products for genes affiliated with Cocaine Abuse

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  • Lysates
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Sources for Cocaine Abuse

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet