MCID: CCN002
MIFTS: 51

Cocaine Abuse malady

Mental diseases category
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Summaries for Cocaine Abuse

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Disease Ontology:8 A substance abuse that involves the recurring use of cocaine despite negative consequences.

MalaCards based summary: Cocaine Abuse is related to neuroleptic malignant syndrome and personality disorder. An important gene associated with Cocaine Abuse is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Monoamine Transport and Amphetamine addiction. The compounds ibzm and octopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, uterus and placenta, and related mouse phenotypes are mortality/aging and endocrine/exocrine gland.

Aliases & Classifications for Cocaine Abuse

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Cocaine Abuse, Aliases & Descriptions:

Name: Cocaine Abuse 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:809
MeSH34 D019970
SNOMED-CT57 78267003
ICD9CM27 305.6, 305.60

Related Diseases for Cocaine Abuse

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Diseases related to Cocaine Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1neuroleptic malignant syndrome31.0DRD2
2personality disorder30.7SLC6A3, DRD2
3substance abuse30.7DRD2, SLC6A3
4attention deficit hyperactivity disorder30.6SLC6A3, DRD2, DBH
5antisocial personality disorder30.5SLC6A3, DRD2
6alcohol abuse30.5SLC6A3, DRD2
7alcohol dependence30.4OPRK1, DRD2
8hyperprolactinemia30.4DBH, DRD2
9bipolar disorder30.4HTR3A, DRD2
10ischemia30.3SLC6A3, OPRK1, DRD2
11pheochromocytoma30.2SLC6A3, DRD2, DBH
12drug dependence30.0SLC6A3, OPRK1, DRD2
13drug addiction30.0DRD2, OPRK1, SLC6A3
14obesity30.0SLC6A3, DRD2, BCHE
15cocaine dependence29.9SLC6A3, OPRK1, DRD2, DBH
16migraine29.8DBH, HTR3A, DRD2, SLC6A3
17dementia29.8HTR3A, BCHE, OPRK1, SLC6A3
18schizophrenia29.3DBH, HTR3A, BCHE, DRD2, OPRK1, SLC6A3
19cerebritis10.5
20oppositional defiant disorder10.5SLC6A3
21vasculitis10.5
22myocardial infarction10.4
23blindness10.4
24nicotine dependence10.3DRD2
25dilated cardiomyopathy10.3
26neuronitis10.3
27aneurysm10.3
28acute myocardial infarction10.3
29atherosclerosis10.3
30thrombocytopenia10.3
31priapism10.3
32placental abruption10.3
33wegener's granulomatosis10.3
34cellulitis10.3
35colitis10.3
36esophagitis10.3
37keratitis10.3
38pancreatitis10.3
39sickle cell disease10.3
40pathological gambling10.3SLC6A3, DRD2
41striatonigral degeneration10.2DRD2, SLC6A3
42substance dependence10.2DRD2, SLC6A3
43progressive supranuclear palsy10.2SLC6A3, DRD2
44lewy body dementia10.2SLC6A3, BCHE
45wilson disease10.2DRD2, SLC6A3
46gilles de la tourette syndrome10.2DRD2, SLC6A3
47movement disease10.2SLC6A3, DRD2
48memory impairment10.1BCHE, SLC6A3
49social phobia10.1HTR3A, DRD2
50restless legs syndrome10.1DRD2, HTR3A

Graphical network of the top 20 diseases related to Cocaine Abuse:



Diseases related to cocaine abuse

Symptoms for Cocaine Abuse

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Drugs & Therapeutics for Cocaine Abuse

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Drug clinical trials:

Search ClinicalTrials for Cocaine Abuse

Search NIH Clinical Center for Cocaine Abuse

Genetic Tests for Cocaine Abuse

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Anatomical Context for Cocaine Abuse

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MalaCards organs/tissues related to Cocaine Abuse:

32
Brain, Uterus, Placenta, Testes, Lung, Pituitary, Cortex, Heart, Skin, Prefrontal cortex, Thalamus, Amygdala

Animal Models for Cocaine Abuse or affiliated genes

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MGI Mouse Phenotypes related to Cocaine Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.9SLC6A3, DRD2, BCHE, HTR3A, DBH
2MP:00053797.8SLC6A3, OPRK1, DRD2, HTR3A, DBH
3MP:00107717.7DBH, HTR3A, DRD2, OPRK1, SLC6A3
4MP:00053767.6DBH, HTR3A, BCHE, DRD2, SLC6A3
5MP:00053897.6SLC6A3, OPRK1, DRD2, BCHE, HTR3A
6MP:00053867.5DBH, HTR3A, DRD2, OPRK1, SLC6A3

Publications for Cocaine Abuse

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Articles related to Cocaine Abuse:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Salvinorin A analogs and other I_-opioid receptor compounds as treatments for cocaine abuse. (24484985)
2014
2
Levamisole-induced occlusive necrotising vasculitis in cocaine abusers: an unusual cause of skin necrosis and neutropenia. (22716045)
2013
3
The impact of contingency management on quality of life among cocaine abusers with and without alcohol dependence. (22211346)
2012
4
Association between cocaine abuse in pregnancy and placenta-associated syndromes using propensity score matching approach. (21975278)
2012
5
Sex hormones: a new treatment for cocaine abuse? (21918518)
2011
6
Cocaine abuse among patients: a study at the Charleston Area Medical Center. (21932758)
2010
7
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
8
Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuse. (17170312)
2007
9
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. (17715210)
2007
10
Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse. (16584128)
2006
11
Severe destructive sinusitis and orbital apex syndrome as a complication of intranasal cocaine abuse. (16787814)
2006
12
Rhabdomyolysis of the left upper leg after cocaine abuse. (16883771)
2006
13
Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum. (16110277)
2005
14
Pharmacotherapy and other treatments for cocaine abuse and dependence. (16639150)
2005
15
Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. (12684441)
2003
16
Olanzapine treatment for patients with schizophrenia and cocaine abuse. (12530415)
2002
17
Commentary on auricular acupuncture for cocaine abuse. (12013511)
2002
18
The effects of maternal cocaine abuse on mothers and newborns. (11123004)
2000
19
The role of weight control as a motivation for cocaine abuse. (9573424)
1998
20
Pharmacotherapy for opioid and cocaine abuse. (9222260)
1997
21
Can cocaine abuse cause parkinsonism? (9134080)
1997
22
A randomized double-blind study of carbamazepine in the treatment of cocaine abuse. (9246023)
1997
23
Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. (9372557)
1997
24
Brief coping skills treatment for cocaine abuse: substance use outcomes at three months. (9581004)
1997
25
Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients. (8841686)
1996
26
Intracranial hemorrhage associated with cocaine abuse: a prospective autopsy study. (8628469)
1996
27
Nasal cocaine abuse mimicking midline granuloma. (7829720)
1995
28
The prevalence of cocaine abuse during pregnancy in Barcelona. (7821487)
1994
29
Comparative cocaine abuse treatment strategies: enhancing client retention and treatment exposure. (7734463)
1994
30
Priapism associated with chronic cocaine abuse. (8042894)
1994
31
Cocaine abuse in methadone maintenance programs: integrating pharmacotherapy with psychosocial interventions. (7931858)
1994
32
Index of suspicion. Case 1. Diagnosis: cocaine abuse. (8247971)
1993
33
The antecedents of women's crack cocaine abuse: family substance abuse, sexual abuse, depression and illicit drug use. (8246316)
1993
34
Neonatal intestinal ischemia with bowel perforation: an in utero complication of maternal cocaine abuse. (1590129)
1992
35
Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics. (1317046)
1992
36
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
37
Central nervous system infarction related to cocaine abuse. (1926246)
1991
38
Cocaine abuse by medical students. (1985598)
1991
39
Plasma prolactin levels and cocaine abuse. (1992852)
1991
40
Pharmacologic treatment of cocaine abuse. (1949942)
1991
41
Cocaine abuse in maternal-child health care. (2172440)
1990
42
Hyperprolactinemia and risk for relapse of cocaine abuse. (2257288)
1990
43
Effects of maternal cocaine abuse on perinatal and infant outcome. (2338984)
1990
44
Priapism associated with intranasal cocaine abuse. (2304177)
1990
45
Rhabdomyolysis and acute renal failure associated with cocaine abuse. (2231831)
1990
46
Panic disorder and cocaine abuse in alcoholics. (2211546)
1990
47
Presidential address of the SSCI. Metabolic and social consequences of cocaine abuse. (2356849)
1990
48
Cocaine abuse during pregnancy: correlation between prenatal care and perinatal outcome. (2586952)
1989
49
Cocaine abuse: what every emergency nurse should know. (2668596)
1989
50
Placental abruption associated with cocaine abuse. (3285653)
1988

Variations for Cocaine Abuse

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Expression for genes affiliated with Cocaine Abuse

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Expression patterns in normal tissues for genes affiliated with Cocaine Abuse

Search GEO for disease gene expression data for Cocaine Abuse.

Pathways for genes affiliated with Cocaine Abuse

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Pathways related to Cocaine Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity37
9.6SLC6A3, DBH
2
Show member pathways
9.5SLC6A3, DRD2
3
Show member pathways
8.9SLC6A3, DRD2, HTR3A

Compounds for genes affiliated with Cocaine Abuse

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Compounds related to Cocaine Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1ibzm449.8DRD2, SLC6A3
2octopamine44 2810.8DBH, SLC6A3
3tetrabenazine44 28 61 50 1113.7DRD2, SLC6A3
4tiapride449.7BCHE, DRD2
5alizapride44 1110.7DRD2, HTR3A
6d amphetamine449.7SLC6A3, DRD2
7ipecac449.7HTR3A, BCHE
8droperidol44 1110.6HTR3A, DRD2
9amperozide449.6HTR3A, DRD2
10ephedrine44 28 1111.5BCHE, SLC6A3
11alpha-methyl-p-tyrosine449.5DBH, DRD2, SLC6A3
12maoa449.5SLC6A3, DRD2, DBH
13tyramine44 28 2411.5DBH, BCHE, SLC6A3
146-hydroxydopamine449.4SLC6A3, DRD2, DBH
15sulpiride44 28 1111.4BCHE, DRD2, SLC6A3
16mptp449.4SLC6A3, DRD2, DBH
17benzamide2 4410.4HTR3A, DRD2
18remifentanil44 1110.4BCHE, OPRK1
19procaine44 28 1111.3SLC6A3, BCHE, HTR3A
20granisetron50 44 1111.3DRD2, HTR3A
21imipramine44 28 50 24 1113.3DBH, HTR3A, SLC6A3
22carbidopa44 2810.3SLC6A3, DBH
23quetiapine44 50 28 24 1113.3HTR3A, DRD2, SLC6A3
24risperidone44 50 28 61 24 1114.3HTR3A, DRD2, SLC6A3
25fluoxetine44 50 28 1112.3HTR3A, DRD2, SLC6A3
26hallucinogen449.3HTR3A, OPRK1
27metoclopramide44 50 1111.3DRD2, HTR3A, DBH
28olanzapine44 50 28 24 1113.2HTR3A, DRD2, SLC6A3
29chlorpromazine28 44 50 1112.2HTR3A, BCHE, DRD2
30haloperidol44 50 28 2 1113.1SLC6A3, DRD2, HTR3A
31amphetamine44 50 1111.1DRD2, OPRK1, SLC6A3
32ibogaine449.1SLC6A3, OPRK1, HTR3A
33choline44 24 1111.0SLC6A3, BCHE, DBH
345-hydroxytryptamine448.9SLC6A3, DRD2, HTR3A, DBH
35lead448.9OPRK1, BCHE, DBH
36opiate448.7SLC6A3, OPRK1, DRD2, DBH
37levodopa44 119.7DBH, DRD2, OPRK1, SLC6A3
38morphine44 50 28 1111.7SLC6A3, OPRK1, DRD2, DBH
39heroin44 50 1110.6BCHE, DRD2, OPRK1, SLC6A3
40nmda44 289.6SLC6A3, OPRK1, DRD2, BCHE
41amitriptyline44 28 50 1111.5HTR3A, BCHE, OPRK1, SLC6A3
42clozapine44 28 50 1111.5HTR3A, DRD2, OPRK1, SLC6A3
43amine448.5DBH, HTR3A, BCHE, OPRK1
44cocaine44 119.2DBH, BCHE, DRD2, OPRK1, SLC6A3
45nicotine44 28 50 1111.2DBH, BCHE, DRD2, OPRK1, SLC6A3
46glutamate448.1DBH, BCHE, DRD2, OPRK1, SLC6A3
47gaba448.1SLC6A3, OPRK1, DRD2, HTR3A, DBH
48dopamine44 28 24 1111.1DBH, HTR3A, DRD2, OPRK1, SLC6A3
49norepinephrine44 24 119.6SLC6A3, OPRK1, DRD2, BCHE, HTR3A, DBH
50acetylcholine44 50 28 24 1111.6DBH, HTR3A, BCHE, DRD2, OPRK1, SLC6A3

GO Terms for genes affiliated with Cocaine Abuse

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Cellular components related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.6SLC6A3, DRD2, HTR3A
2integral component of plasma membraneGO:0058878.1SLC6A3, OPRK1, DRD2, HTR3A

Biological processes related to Cocaine Abuse according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.9SLC6A3, DBH
2adenohypophysis developmentGO:0219849.8SLC6A3, DRD2
3response to iron ionGO:0100399.7DRD2, SLC6A3
4prepulse inhibitionGO:0601349.7SLC6A3, DRD2
5behavioral response to ethanolGO:0481499.7DRD2, DBH
6response to nicotineGO:0350949.7SLC6A3, DRD2
7response to amphetamineGO:0019759.6DBH, DRD2
8positive regulation of multicellular organism growthGO:0400189.5SLC6A3, DRD2
9response to ethanolGO:0454719.4SLC6A3, HTR3A
10visual learningGO:0085429.4DBH, DRD2
11sensory perception of smellGO:0076089.2SLC6A3, DRD2
12response to cocaineGO:0422209.2SLC6A3, DRD2, HTR3A
13response to drugGO:0424939.1BCHE, DRD2, SLC6A3
14locomotory behaviorGO:0076268.6SLC6A3, OPRK1, DRD2, DBH
15synaptic transmissionGO:0072688.4DBH, HTR3A, OPRK1, SLC6A3

Molecular functions related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catalytic activityGO:0038249.5BCHE, DBH
2dopamine bindingGO:0352409.4SLC6A3, DRD2
3drug bindingGO:0081449.2SLC6A3, DRD2

Products for genes affiliated with Cocaine Abuse

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Sources for Cocaine Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet