Cocaine Abuse malady

Disease Ontology: A substance abuse that involves the recurring use of cocaine despite negative consequences.⁶

MalaCards: Cocaine Abuse is related to neuronitis and leptin receptor deficiency. An important gene associated with Cocaine Abuse is MOBP (myelin-associated oligodendrocyte basic protein), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The compounds nicotine and tyramine have been mentioned in the context of this disorder. Affiliated tissues include brain and pituitary, and related mouse phenotypes are endocrine/exocrine gland and taste/olfaction.

Aliases & Descriptions:

cocaine abuse 6 8 32 43

Diseases related to cocaine abuse by text searches and GeneDecks gene sharing:

(show top 50)    (show all 250)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	19.8	PIK3C2A, RECK, BDNF, BCHE, CHKB, LAMB1
2	leptin receptor deficiency	13.7	DRD2, SLC6A3
3	major affective disorder	13.6	HTR3A, DRD2, SLC6A4
4	social phobia	13.6	HTR3A, DRD2, SLC6A4
5	opiate dependence	13.6	DRD2, PDYN, OPRK1
6	conduction disease	13.6	DBH, SLC6A3, SLC6A4
7	autonomic dysfunction	13.5	DBH, SLC6A2
8	sepiapterin reductase deficiency	13.5	DRD2, SLC6A3, SLC18A2
9	amnestic disorder	13.5	HTR3A, PDYN, OPRK1
10	migraine with aura	13.5	DRD2, DBH, SLC6A3, SLC6A4
11	gilles de la tourette syndrome	13.5	HTR3A, DRD2, DBH, SLC6A3
12	generalized anxiety disorder	13.5	HTR3A, SLC6A2, SLC6A4
13	quadriplegia	13.5	PIK3C2A, DBH
14	lewy body dementia	13.4	SNCB, SNCA
15	alcoholic psychosis	13.4	SLC6A3, SLC6A4
16	striatonigral degeneration	13.4	DRD2, SNCA, SLC6A3
17	personality disorder	13.4	MAOB, DRD2, SLC6A3, SLC6A4
18	bipolar disorder	13.4	BDNF, SLC6A4
19	pathological gambling	13.4	MAOB, DRD2, SLC6A3, SLC6A4
20	pure autonomic failure	13.4	SNCA, DBH
21	progressive supranuclear palsy	13.3	DRD2, SNCA, SLC6A3
22	post-traumatic stress disorder	13.3	BDNF, DRD2, DBH
23	rem sleep behavior disorder	13.3	SNCA, SLC6A3
24	aggressive digital papillary adenocarcinoma	13.3	MAOB, HTR3A, DRD2, SLC6A4
25	manic-depressive illness	13.3	MAOB, DRD2, DBH, SLC6A3, SLC6A4
26	neurotic disorder	13.2	BDNF, HTR3A, DRD2, SLC6A4
27	compartment syndrome	13.2	CHKB, MB
28	eating disorder	13.2	BDNF, HTR3A, SLC6A3, SLC6A4
29	movement disease	13.2	DRD2, SNCA, SLC6A3, SLC18A2
30	orthostatic hypotension	13.2	MAOB, SNCA, DBH
31	fibrillary astrocytoma	13.2	CHKB, SNCB, SNCA
32	transverse myelitis	13.2	APOH, MBP
33	sudden infant death syndrome	13.2	MAOB, HTR3A, SLC6A3, SLC6A4
34	constipation	13.2	HTR3A, PDYN, DBH, SLC6A2, SLC6A4
35	fetal akinesia syndrome x-linked	13.2	MAOB, SNCA
36	riley-day syndrome	13.1	BDNF, DBH
37	spinocerebellar ataxia type 3	13.1	HTR3A, SNCA, SLC6A3
38	leukodystrophy	13.1	MBP, PLP1, SLC6A3, SLC6A4
39	panic disorder	13.1	HTR3A, POMC, SLC6A4
40	creatine phosphokinase, elevated serum	13.1	PIK3C2A, CHKB, MB
41	bipolar i disorder	13.1	BDNF, DRD2, SLC6A4, SLC18A2
42	gas gangrene	13.1	PIK3C2A, CHKB, MB
43	tremor	13.0	HTR3A, DRD2, SNCA, PLP1, SLC6A3, SLC6A4
44	creatine phosphokinase	13.0	PIK3C2A, CHKB, MB
45	rhabdomyolysis, cerivastatin-induced	13.0	PIK3C2A, CHKB, MB
46	congestive heart failure	13.0	PIK3C2A, CHKB, PDYN, DBH
47	cannabis abuse	13.0	BDNF, NGF
48	olivopontocerebellar atrophy	13.0	MBP, SNCA, SLC6A3
49	nervous system disease	13.0	APOH, MBP, PLP1
50	anxiety-related personality traits	12.9	BDNF, NGF, SLC6A4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cocaine abuse:

²²

MGI Mouse Phenotypes related to cocaine abuse:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.8	CARTPT, DBH, OPRK1
2	taste/olfaction phenotype	MP:0005394	8.9	ADRBK2, SLC18A2, SLC6A3, SNCA, DRD2, BDNF
3	reproductive system phenotype	MP:0005389	8.6	PRL, PLP1, SNCA, DRD2, BCHE, CLDN11
4	integument phenotype	MP:0010771	6.4	PRL, OPRK1, POMC, SLC6A2, SLC6A3, SLC6A4
5	growth/size phenotype	MP:0005378	5.6	NGF, PDYN, TF, DBH, POMC, SLC6A2
6	mortality/aging	MP:0010768	4.8	SNCA, PLP1, NGF, TF, DBH, POMC
7	nervous system phenotype	MP:0003631	4.7	NGF, PDYN, DBH, PRL, POMC, SLC6A2
8	behavior/neurological phenotype	MP:0005386	4.6	CLDN11, PDYN, DBH, PRL, OPRK1, POMC
9	homeostasis/metabolism phenotype	MP:0005376	3.9	TF, PDYN, PLP1, SNCA, DBH, PRL

Articles related to cocaine abuse:

(show all 40)

id	Title	Authors	Year	Affiliating Genes
1	Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. (21150907)	Moyer R.A.... Sadee W.	2011	DRD2
2	Striatal dopamine D2 receptor availability predicts t he thalamic and medial prefrontal responses to reward in cocaine abusers three years later. (20034014)	Asensio S.... Goldstein R.Z.	2010	DRD2
3	Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. (18357522)	Kristiansen L.V.... Meador-Woodruff J.H.	2009	TF, PLP1, CLDN11
4	Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuse. (18579413)	Chang L.... Fowler J.S.	2008	DRD2, SLC6A3
5	The novel N-substituted benztropine analog GA2-50 pos sesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate s ubstitute medication for cocaine abuse. (18425847)	Othman A.A.... Eddington N.D.	2008	SLC6A3
6	Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. (18055133)	Mash D.C.... Ervin F.R.	2008	SNCA
7	Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. (17391744)	Goletiani N.V.... Mello N.K.	2007	POMC, PRL
8	Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. (17715210)	Angelucci F.... Bria P.	2007	BDNF, NGF
9	Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (18000554)	Mash D.C.... Pablo J.	2007	LAMB1, RECK
10	CART mRNA expression in rat monkey and human brain: relevance to cocaine abuse. (17631364)	Fagergren P.... Hurd Y.	2007	CARTPT
11	Association analysis of GRK3 gene promoter variants in cocaine abuse. (17621168)	Guindalini C.... Breen G.	2007	ADRBK2
12	A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. (16537431)	Guindalini C.... Breen G.	2006	SLC6A3
13	Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls. (17000009)	Mannelli P.... Berrettini W.H.	2006	PRL, SLC6A4
14	Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum. (16110277)	Qin Y.... Mash D.C.	2005	SNCA, SLC6A3
15	Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers. (15763139)	Mash D.C.... Pablo J.	2005	SLC6A2
16	Gene expression profiling in the brains of human cocaine abusers. (15849025)	Bannon M.... Albertson D.	2005	MBP, PLP1, MOBP
17	PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. (16055768)	Nader M.A.... Czoty P.W.	2005	DRD2
18	Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. (15009677)	Albertson D.N.... Bannon M.J.	2004	MBP, PLP1, MOBP
19	Agents in development for the management of cocaine abuse. (15233592)	Gorelick D.A.... Xi Z.X.	2004	MAOB, DBH, SLC6A3
20	Treatment-seeking inpatient cocaine abusers show hypo thalamic dysregulation of both basal prolactin and cortisol secretion. (14512708)	Contoreggi C.... Hess J.	2003	PRL
21	Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. (12684441)	Mash D.C.... Perrin R.J.	2003	SNCA, SNCB
22	Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piper azines as potential cocaine abuse therapeutic agents. (12565970)	Hsin L.W.... Rice K.C.	2003	SLC6A3, SLC6A4
23	Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. (12801223)	Cao J.... Newman A.H.	2003	SLC6A3, SIGMAR1
24	Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. (11959923)	Bannon M.J.... Schmidt C.J.	2002	NR4A2
25	Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. (12210554)	Newman A.H.... Kulkarni S.	2002	SLC6A3, SLC18A2
26	Association of methylphenidate-induced craving with c hanges in right striato-orbitofrontal metabolism in cocaine abusers: implicatio ns in addiction. (9892293)	Volkow N.D.... Pappas N.	1999	DRD2
27	Should cocaine-abusing, buprenorphine-maintained pati ents receive auricular acupuncture? Findings from an acute effects study. (10630350)	Margolin A.... Avants S.K.	1999	PDYN
28	Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)pipera zines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents. (10585212)	Lewis D.B.... Rice K.C.	1999	SLC6A3
29	Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. (9372557)	Logan J.... Shea C.E.	1997	SLC6A3
30	Cocaine abusers do not show loss of dopamine transpor ters with age. (9307051)	Wang G.J.... Pappas N.R.	1997	SLC6A3
31	Ibogaine and cocaine abuse: pharmacological interactions at dopamine and serotonin receptors. (8995326)	Sershen H.... Lajtha A.	1997	HTR3A
32	Cocaine uptake is decreased in the brain of detoxifie d cocaine abusers. (8866699)	Volkow N.D.... Wolf A.P.	1996	SLC6A3
33	Effects of intravenous cocaine on plasma cortisol and prolactin in human cocaine abusers. (8580229)	Baumann M.H.... Rothman R.B.	1995	PRL
34	Decreased dopamine D2 receptor availability is associ ated with reduced frontal metabolism in cocaine abusers. (8101394)	Volkow N.D.... Wolf A.P.	1993	DRD2
35	Elevated serum CK in long abstinent cocaine abusers. (8213696)	Swartz C.M.... Breen K.J.	1993	CHKB
36	Observations on increased CPK levels in 'asymptomatic' cocaine abusers. (1486096)	Warrian W.G.... Crea F.	1992	PIK3C2A
37	Neurobiology of cocaine abuse. (1604712)	Woolverton W.L.... Johnson K.M.	1992	DRD2
38	Rhabdomyolysis associated with cocaine abuse. (1743698)	Nolte K.B.	1991	MB
39	Detection of anticardiolipin antibody in patients wit h cocaine abuse. (1955680)	Fritsma G.A.... Hryhorczuk D.O.	1991	APOH
40	Dopaminergic sensitivity and cocaine abuse: response to apomorphine. (2243893)	Hollander E.... Klein D.F.	1990	PRL

Genes related to cocaine abuse according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	MOBP	myelin-associated oligodendrocyte basic protein	11.0	Publications
2	PLP1	proteolipid protein 1	11.0	Publications
3	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
4	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
5	DRD2	dopamine receptor D2	11.0	Publications
6	OPRK1	opioid receptor, kappa 1	11.0
7	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
8	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
9	BCHE	butyrylcholinesterase	11.0
10	CRIP2	cysteine-rich protein 2	11.0
11	CARTPT	CART prepropeptide	11.0	Publications
12	CLDN11	claudin 11	11.0	Publications
13	SNCB	synuclein, beta	11.0	Publications
14	SIGMAR1	sigma non-opioid intracellular receptor 1	11.0	Publications
15	NGB	neuroglobin	11.0
16	PPFIA3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	11.0
17	NR4A2	nuclear receptor subfamily 4, group A, member 2	11.0	Publications
18	PDYN	prodynorphin	11.0	Publications
19	SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	11.0	Publications
20	LAMB1	laminin, beta 1	11.0	Publications
21	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	11.0	Publications
22	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
23	ADRBK2	adrenergic, beta, receptor kinase 2	11.0	Publications
24	INTS8	integrator complex subunit 8	11.0
25	CHKB	choline kinase beta	11.0	Publications
26	MB	myoglobin	11.0	Publications
27	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
28	MAOB	monoamine oxidase B	11.0	Publications
29	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
30	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
31	BDNF	brain-derived neurotrophic factor	11.0	Publications
32	TF	transferrin	11.0	Publications
33	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
34	MBP	myelin basic protein	11.0	Publications
35	PRL	prolactin	11.0	Publications
36	POMC	proopiomelanocortin	11.0	Publications

Pathways related to cocaine abuse according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Sympathetic Nerve Pathway (Neuroeffector Junction)34	9.9	DBH, SLC6A2, SLC18A2
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.8	SLC6A4, SLC18A2

Compounds related to cocaine abuse according to GeneDecks:

(show top 50)    (show all 268)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.4	SLC6A2, OPRK1, PDYN
2	tyramine32 18	11.0	BCHE, SLC6A2, MAOB
3	mazindol32 9 9	11.8	MAOB, SLC18A2, SLC6A4, SLC6A3, SLC6A2
4	methylphenidate32 9 9	11.7	SLC6A3, SLC6A2, DRD2, SLC18A2, SLC6A4, MAOB
5	MMDA9 9	10.6	SLC6A4, SLC6A3, SLC6A2, SLC18A2, MAOB
6	d amphetamine32	9.6	DRD2, MAOB, SLC6A2, SLC6A4, SLC6A3
7	amitriptyline32 34 42 9 9	13.6	SLC6A2, SLC6A4, BCHE, MAOB, HTR3A, SLC6A3
8	venlafaxine32 34 9 18 9	13.6	SLC6A3, SLC18A2, SLC6A4, SLC6A2, HTR3A, BDNF
9	glucose32	9.5	NGB, LAMB1, PDYN, SLC18A2, SLC6A2
10	spec-t32	9.4	CHKB, MAOB, DRD2, SLC18A2, SLC6A2, SLC6A3
11	sertraline32 34 9 18 9	13.3	MAOB, HTR3A, SLC6A4, SLC6A3, SLC6A2, POMC
12	amine32	9.3	DBH, SLC6A4, SLC18A2, OPRK1, SLC6A2, BCHE
13	heroin32 9 9	11.3	SLC6A4, SLC6A3, POMC, OPRK1, PDYN, DRD2
14	ketamine32 9 9	11.2	BDNF, DRD2, SLC6A3, SLC6A4, SLC18A2, MB
15	imipramine32 34 9 18 9	13.2	SLC6A3, SLC6A2, SLC6A4, SLC18A2, HTR3A, BDNF
16	1 methyl 4 phenylpyridinium32	9.1	BDNF, SNCA, SLC18A2, SLC6A4, SLC6A3, MAOB
17	mdma32	9.0	SLC18A2, SLC6A4, SLC6A3, SLC6A2, PRL, MAOB
18	maoa32	8.9	DRD2, DBH, POMC, SLC6A2, SLC6A3, SLC6A4
19	risperidone32 34 9 18 9	12.8	BDNF, CHKB, HTR3A, DRD2, PRL, SLC6A3
20	mhpg32	8.8	MAOB, DBH, PRL, SLC6A2, SLC6A4, BDNF
21	homovanillic acid32 18	9.7	MAOB, BDNF, DBH, PRL, SLC6A2, SLC6A4
22	glutamate32	8.7	MBP, SLC18A2, OPRK1, PDYN, PLP1, SNCA
23	clozapine32 34 9 9	11.6	PRL, CHKB, HTR3A, DRD2, OPRK1, POMC
24	chlorpromazine32 9 9	10.6	APOH, DRD2, HTR3A, CHKB, BCHE, BDNF
25	choline32 9 18 9	11.5	TF, NGF, SNCA, MAOB, CHKB, PIK3C2A
26	citalopram32 34 9 18 9	12.5	HTR3A, PRL, SLC18A2, SLC6A2, SLC6A3, SLC6A4
27	amphetamine32 9 9	10.4	SLC6A2, POMC, OPRK1, PDYN, SNCA, DRD2
28	mptp32	8.4	BDNF, MAOB, DRD2, SNCA, NGF, DBH
29	selegiline32 9 9	10.3	SLC6A3, BDNF, NGF, SNCA, MAOB, BCHE
30	methamphetamine32 9 9	10.3	SLC6A3, SLC6A4, SLC18A2, ADRBK2, BDNF, MB
31	6-hydroxydopamine32	8.3	DBH, PDYN, NGF, BDNF, MAOB, DRD2
32	opiate32	8.3	PDYN, SLC6A4, SLC6A3, POMC, OPRK1, DBH
33	5-hydroxytryptamine32	8.1	SLC6A2, SLC6A3, SLC6A4, SLC18A2, POMC, DBH
34	catecholamine32	7.9	BDNF, PIK3C2A, MAOB, SNCA, PDYN, DBH
35	fluoxetine32 34 9 9	10.9	SLC18A2, SLC6A4, SLC6A3, SLC6A2, PRL, NGF
36	haloperidol32 34 9 9	10.2	MAOB, MB, BDNF, PIK3C2A, HTR3A, DRD2
37	lactate32	7.1	PDYN, TF, DBH, MAOB, PIK3C2A, RECK
38	h2o232	7.1	MB, BCHE, SLC6A4, SLC6A3, POMC, DBH
39	creatinine32	7.0	BDNF, TF, NGF, MAOB, MBP, MB
40	aspartate32	6.9	MB, BDNF, BCHE, CHKB, MBP, SLC6A2
41	gaba32 42	7.9	SLC18A2, SLC6A4, SLC6A3, SLC6A2, POMC, OPRK1
42	dopamine32 9 18 9	9.8	SLC18A2, MB, CHKB, BDNF, MAOB, HTR3A
43	levodopa32 9 9	8.8	MAOB, SLC18A2, SLC6A3, OPRK1, PRL, DBH
44	cysteine32	6.8	RECK, MB, CHKB, OPRK1, SNCA, PLP1
45	alanine32	6.5	ADRBK2, BCHE, SLC6A2, SLC6A4, CHKB, MB
46	acetylcholine32 9 18 9	9.2	POMC, OPRK1, DBH, PDYN, NGF, PLP1
47	arginine32	5.8	MBP, SLC6A4, SLC6A3, MB, RECK, SNCA
48	epinephrine32 9 18 9	8.1	TF, PDYN, NGF, DRD2, MAOB, MBP
49	norepinephrine32 9 18 9	7.0	PDYN, NGF, NR4A2, DRD2, HTR3A, MAOB
50	cocaine32 9 9	5.7	POMC, OPRK1, PRL, DBH, TF, PDYN

Cellular components related to cocaine abuse according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	terminal button	GO:043195	9.7	SLC18A2, DBH, SNCB
2	compact myelin	GO:043218	9.6	MBP, PLP1
3	secretory granule	GO:030141	9.3	CARTPT, TF, DBH, POMC
4	neuronal cell body	GO:043025	9.3	SLC18A2, SLC6A3, DBH, HTR3A, MBP
5	extracellular region	GO:005576	6.7	PRL, DBH, TF, PDYN, NGF, SNCA

Biological processes related to cocaine abuse according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to iron ion	GO:010039	10.3	SLC6A3, DBH, DRD2
2	dopamine catabolic process	GO:042420	10.2	SLC6A3, DBH
3	behavioral response to ethanol	GO:048149	10.2	DRD2, DBH
4	response to cocaine	GO:042220	10.1	HTR3A, DRD2, SLC6A3, SLC18A2
5	locomotory behavior	GO:007626	10.1	DRD2, DBH, SLC6A3, SLC18A2
6	response to amphetamine	GO:001975	10.1	DRD2, DBH, SLC18A2
7	monoamine transport	GO:015844	10.1	SLC18A2, SLC6A4, SLC6A3, SLC6A2
8	response to nicotine	GO:035094	9.9	DRD2, NGF, SLC6A3
9	fear response	GO:042596	9.6	BDNF, DBH
10	axon ensheathment	GO:008366	9.6	MBP, PLP1
11	response to toxin	GO:009636	9.5	SLC6A4, DRD2, MAOB, MBP
12	negative regulation of neuron apoptotic process	GO:043524	9.1	NGF, SNCA, SNCB, BDNF
13	synaptic transmission	GO:007268	8.6	MBP, SLC18A2, SLC6A3, SLC6A2, OPRK1, DBH
14	response to drug	GO:042493	8.6	SLC6A4, SLC6A3, NGF, SNCA, DRD2, MAOB

Molecular functions related to cocaine abuse according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serotonin transmembrane transporter activity	GO:015222	10.1	SLC6A4, SLC18A2
2	monoamine transmembrane transporter activity	GO:008504	9.8	SLC6A2, SLC6A3, SLC6A4, SLC18A2
3	drug binding	GO:008144	9.6	DRD2, SLC6A3, SLC18A2, SIGMAR1
4	structural constituent of myelin sheath	GO:019911	9.5	PLP1, MBP, MOBP