MCID: CCN002
MIFTS: 53

Cocaine Abuse malady

Summaries for Cocaine Abuse

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A substance abuse that involves the recurring use of cocaine despite negative consequences.

MalaCards: Cocaine Abuse is related to alcohol abuse and cocaine dependence. An important gene associated with Cocaine Abuse is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Selected targets of CREB1. The compounds gbr 12909 and nisoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, uterus and testes, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Cocaine Abuse

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

cocaine abuse 8 10 44 60


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Disease Ontology8 DOID:809
MeSH34 D019970
SNOMED-CT56 78267003
ICD9CM27 305.6, 305.60

Related Diseases for Cocaine Abuse

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17GeneCards, 18GeneDecks
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Diseases related to Cocaine Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.0SLC6A4, SLC6A3, DRD2
2cocaine dependence31.0SLC18A2, SLC6A4, SLC6A3, PDYN, DRD2, OPRK1
3alcohol dependence30.6SLC6A4, OPRK1, DRD2
4ischemia30.6PDYN, DRD2, OPRK1, NGB, SLC6A3, SLC6A2
5substance abuse30.5DRD2, SLC6A3, SLC6A4
6attention deficit hyperactivity disorder30.4DRD2, DBH, SLC6A3, SLC6A4, SLC6A2
7schizophrenia30.4BCHE, SLC18A2, SLC6A2, SLC6A4, MOBP, PDYN
8personality disorder30.3SLC6A4, SLC6A3, DRD2
9neuroleptic malignant syndrome30.3DRD2
10dementia30.3HTR3A, OPRK1, SNCB, PLP1, SLC6A3, BCHE
11heroin dependence30.1DRD2
12hypertension30.1DBH, SLC6A4
13antisocial personality disorder30.1DRD2, SLC6A3, SLC6A4
14panic disorder30.1SLC6A4, HTR3A
15drug dependence30.1SLC6A4, SLC6A3, OPRK1, DRD2, PDYN
16obesity30.1CARTPT, DRD2, SLC6A3, SLC6A2, BCHE
17migraine30.1HTR3A, DRD2, DBH, SLC6A3, SLC6A4
18bipolar disorder30.1SLC6A4, HTR3A
19pheochromocytoma30.1PDYN, DRD2, DBH, SLC6A3, SLC6A2, SLC18A2
20cerebritis10.5
21opioid abuse10.4
22myocardial infarction10.4
23vasculitis10.4
24neuronitis10.3
25acute myocardial infarction10.3
26dilated cardiomyopathy10.3
27orbital cellulitis10.2
28cellulitis10.2
29wegener's granulomatosis10.2
30cannabis abuse10.2
31priapism10.2
32placental abruption10.2
33atherosclerosis10.2
34esophagitis10.2
35keratitis10.2
36pancreatitis10.2
37thrombocytopenia10.2
38sickle cell disease10.2
39burns10.1
40coronary artery disease10.1
41acute pancreatitis10.1
42antiphospholipid syndrome10.1
43wolff-parkinson-white syndrome10.1
44renal agenesis10.1
45coronary aneurysm10.1
46wound botulism10.1
47hyperprolactinemia10.1
48dependent personality disorder10.1
49intracranial aneurysm10.1
50pharyngitis10.1

Graphical network of the top 20 diseases related to Cocaine Abuse:



Diseases related to cocaine abuse

Clinical Features for Cocaine Abuse

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Drugs & Therapeutics for Cocaine Abuse

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cocaine Abuse

Drug clinical trials:

Search ClinicalTrials for Cocaine Abuse

Search NIH Clinical Center for Cocaine Abuse

Search CenterWatch for Cocaine Abuse

Genetic Tests for Cocaine Abuse

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Anatomical Context for Cocaine Abuse

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32MalaCards
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MalaCards organs/tissues related to Cocaine Abuse:

32
Brain, Uterus, Testes, Placenta, Lung, Pituitary, Thalamus, Cortex, Amygdala, Heart, Skin, Prefrontal cortex

Animal Models for Cocaine Abuse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cocaine Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3CARTPT, HTR3A, DRD2, OPRK1, DBH, CLDN11
2MP:00107719.1PDYN, HTR3A, DRD2, OPRK1, DBH, SLC6A3
3MP:00107688.9DRD2, SNCB, NR4A2, DBH, NGB, PLP1
4MP:00053788.8SNCB, DRD2, HTR3A, PDYN, CARTPT, NR4A2
5MP:00053768.7SNCB, DRD2, HTR3A, PDYN, CARTPT, NR4A2
6MP:00036318.7MOBP, PDYN, HTR3A, DRD2, SNCB, NR4A2
7MP:00053868.3SLC18A2, MOBP, CARTPT, PDYN, HTR3A, DRD2

Publications for Cocaine Abuse

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50PubMed
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Articles related to Cocaine Abuse:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Gastrointestinal complications and esophageal stenosis after crack cocaine abuse. (24008469)
2013
2
Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. (23335468)
2013
3
Clinical and forensic signs related to cocaine abuse. (22280333)
2012
4
Levamisole-induced Wegener's granulomatosis following contaminated cocaine abuse. (23008947)
2012
5
A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder. (21092101)
2010
6
Striatal dopamine D2 receptor availability predicts the thalamic and medial prefrontal responses to reward in cocaine abusers three years later. (20034014)
2010
7
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
8
Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature. (18720516)
2008
9
Cocaine abuse: acute medical manifestations and current recommended management strategies. (21607225)
2008
10
The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. (18425847)
2008
11
Le Fort I osteotomy and the use of bilateral bichat bulla adipose flap: an effective new technique for reconstructing oronasal communications due to cocaine abuse. (18281796)
2008
12
New developments in the pharmacotherapy of cocaine abuse. (17508985)
2007
13
Self-mutilation induced by cocaine abuse: the pleasure of bleeding. (17259032)
2007
14
Four-extremity gangrene associated with crack cocaine abuse. (17059855)
2007
15
Rhabdomyolysis of the left upper leg after cocaine abuse. (16883771)
2006
16
Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum. (16110277)
2005
17
Acute pancreatitis, incomplete thrombotic microangiopathy and cocaine abuse: an unusual pathogenic link. (15959761)
2005
18
Pituitary infarction resulting from intranasal cocaine abuse. (16033719)
2004
19
Collisions and traffic violations of alcohol, cannabis and cocaine abuse clients before and after treatment. (15203356)
2004
20
Driving behavior of alcohol, cannabis, and cocaine abuse treatment clients and population controls. (15230084)
2004
21
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. (12801223)
2003
22
The surgical abdomen associated with cocaine abuse. (12480020)
2002
23
Cocaine abuse: repolarization abnormalities and ventricular arrhythmias. (10910367)
2000
24
Rapid progression of coronary artery disease in the setting of chronic cocaine abuse. (9696183)
1998
25
Preseptal cellulitis and orbital wall destruction secondary to nasal cocaine abuse. (9467464)
1998
26
Methodologic recommendations for cocaine abuse clinical trials: a clinician-researcher's perspective. (9467793)
1997
27
Brain atrophy and chronic cocaine abuse: background and work in progress. (8809852)
1996
28
Buprenorphine as a pharmacotherapy for cocaine abuse: a review of the evidence. (8555282)
1995
29
Uterine rupture in association with alkaloidal ("crack") cocaine abuse. (7631697)
1995
30
Effects of intravenous cocaine on plasma cortisol and prolactin in human cocaine abusers. (8580229)
1995
31
Cocaine abuse and dependence. (7714230)
1995
32
A 28-year-old man with an aortic dissection and history of cocaine abuse. (7630051)
1995
33
The antecedents of women's crack cocaine abuse: family substance abuse, sexual abuse, depression and illicit drug use. (8246316)
1993
34
Cerebral vasculitis associated with cocaine abuse. (8515225)
1993
35
Cardiovascular complications of cocaine abuse. (8385415)
1993
36
Observations on increased CPK levels in "asymptomatic" cocaine abusers. (1486096)
1992
37
Preclinical methods for the development of pharmacotherapies for cocaine abuse. (1435972)
1992
38
Treatment of cocaine abuse: pharmacotherapy. (1638913)
1992
39
Acute transient thrombocytopenia associated with cocaine abuse in pregnancy. (1870806)
1991
40
Cocaine abuse during pregnancy: psychiatric considerations. (1765257)
1991
41
Trends in cocaine abuse reflected in emergency room episodes reported to DAWN. Drug Abuse Warning Network. (1847529)
1991
42
Pott's puffy tumor: a complication of intranasal cocaine abuse. (1925277)
1991
43
Chronic, habitual cocaine abuse and kindling-induced epilepsy: a case report. (1743162)
1991
44
Cocaine abuse in maternal-child health care. (2172440)
1990
45
Rhabdomyolysis and acute renal failure associated with cocaine abuse. (2231831)
1990
46
Presidential address of the SSCI. Metabolic and social consequences of cocaine abuse. (2356849)
1990
47
Intravenous cocaine abuse and subarachnoid haemorrhage: effect on outcome. (2334523)
1990
48
Cocaine abuse in pregnancy--a myriad of unanswered questions. (2232723)
1990
49
Cocaine abuse and its treatment. (2179901)
1990
50
Cocaine abuse: unusual medical complications. (2670853)
1989

Genetic Variations for Cocaine Abuse

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Expression for genes affiliated with Cocaine Abuse

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Abuse

Search GEO for disease gene expression data for Cocaine Abuse.

Pathways for genes affiliated with Cocaine Abuse

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Sources:
49PharmGKB, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Cocaine Abuse

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Cocaine Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1gbr 129094410.3SLC6A2, SLC6A3, SLC6A4, SLC18A2
2nisoxetine44 2811.3SLC18A2, SLC6A2, SLC6A4, SLC6A3
3tropane4410.3SLC18A2, SLC6A2, SLC6A4, SLC6A3
4d amphetamine4410.2SLC6A2, SLC6A4, SLC6A3, DRD2
5maoa4410.2SLC6A2, SLC6A4, DBH, SLC6A3, DRD2
6mazindol44 28 1112.2SLC6A3, SLC6A4, SLC6A2, SLC18A2
73,4-Methylenedioxymethamphetamine1110.2SLC6A4, SLC6A3, SLC6A2, SLC18A2
8milnacipran44 49 1112.2SLC18A2, SLC6A2, SLC6A3, SLC6A4
9tyramine44 28 2412.2SLC6A2, SLC6A4, SLC6A3, DBH, BCHE
10MMDA1110.2SLC6A3, SLC18A2, SLC6A2, SLC6A4
11methylphenidate44 49 1112.2SLC6A4, SLC18A2, SLC6A2, SLC6A3, DRD2
12Tapentadol1110.2HTR3A, SLC6A2, SLC6A4, OPRK1
13reboxetine44 28 1112.2SLC6A3, SLC6A4, SLC18A2, SLC6A2
14heroin44 49 1112.1PDYN, SLC6A3, DRD2, OPRK1, SLC6A4, BCHE
15duloxetine44 49 28 1113.1SLC6A4, SLC6A3, SLC18A2, SLC6A2
16ephedrine28 44 1112.1SLC6A3, SLC6A2, SLC18A2, BCHE
17venlafaxine49 44 11 2413.1SLC18A2, SLC6A2, SLC6A4, SLC6A3, HTR3A
18amitriptyline44 49 28 1113.1OPRK1, SLC6A2, SLC6A4, HTR3A, SLC6A3, BCHE
19opiate4410.1SLC6A3, DBH, OPRK1, PDYN, DRD2, SLC6A4
20bupropion44 49 11 2413.1SLC6A3, SLC18A2, SLC6A2, SLC6A4, DRD2
216-hydroxydopamine4410.1PDYN, SLC6A3, NR4A2, DBH, SLC6A2, DRD2
22indole4410.1HTR3A, OPRK1, SIGMAR1, SLC6A4, SLC18A2
23mdma4410.1SLC6A3, SLC18A2, SLC6A2, SLC6A4
24Ephedra1110.1SLC6A2, SLC6A3, SLC18A2, SLC6A4
25maprotiline44 1111.1SLC6A4, SLC6A2, HTR3A, SLC6A3
26paroxetine44 49 28 1113.1SLC6A3, SLC6A4, HTR3A, SLC18A2, SLC6A2
27fluoxetine49 44 28 1113.0SLC6A3, SLC18A2, SLC6A2, SLC6A4, DRD2, HTR3A
28escitalopram44 49 11 2413.0SLC6A3, SLC18A2, SLC6A4, SLC6A2
29mptp4410.0SLC6A4, DRD2, SLC18A2, SLC6A2, SLC6A3, DBH
30nmda44 2811.0SLC6A3, OPRK1, PDYN, BCHE
31methamphetamine44 49 1112.0SLC6A3, DRD2, SLC6A2, SLC18A2, SLC6A4, PDYN
32imipramine44 49 28 11 2414.0DBH, SLC6A3, SLC6A4, SLC6A2, SLC18A2, HTR3A
33spec-t4410.0DRD2, SLC18A2, SLC6A4, SLC6A2, SLC6A3
34levodopa44 1111.0PDYN, DRD2, DBH, SLC6A3, SLC18A2, OPRK1
35nefazodone44 49 1111.9SLC6A4, SLC6A2, SLC6A3, HTR3A
36amine449.9SLC6A2, BCHE, SLC18A2, SLC6A4, DBH, OPRK1
375-hydroxytryptamine449.9SLC18A2, SLC6A2, SLC6A4, DBH, HTR3A, SLC6A3
38haloperidol44 28 2 49 1113.9SLC18A2, SLC6A2, SLC6A4, SLC6A3, DRD2, HTR3A
39citalopram49 44 11 2412.9SLC18A2, HTR3A, SLC6A2, SLC6A3, SLC6A4
40reserpine44 28 1111.9DRD2, SLC6A3, SLC6A2, SLC18A2
41trimipramine49 44 1111.9DRD2, SLC6A2, SLC6A4, SLC6A3
42amphetamine44 1110.8SLC18A2, SLC6A2, SLC6A4, SLC6A3, OPRK1, PDYN
43sulpiride44 28 1111.7BCHE, SLC6A3, DRD2, PDYN
44nicotine44 49 28 1112.6SLC6A2, DBH, SLC18A2, BCHE, SLC6A4, OPRK1
45glutamate449.4BCHE, SLC18A2, SLC6A2, SLC6A4, DBH, SLC6A3
46gaba449.4SLC6A3, SLC6A4, SLC6A2, SLC18A2, PLP1, DBH
47acetylcholine44 49 28 11 2413.4PDYN, HTR3A, DRD2, OPRK1, DBH, PLP1
48norepinephrine44 11 2411.4PDYN, HTR3A, DRD2, OPRK1, NR4A2, DBH
49dopamine44 28 11 2412.2SLC18A2, CARTPT, PDYN, HTR3A, DRD2, OPRK1
50cocaine44 1110.1PDYN, DRD2, OPRK1, DBH, BCHE, SLC18A2

GO Terms for genes affiliated with Cocaine Abuse

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16Gene Ontology
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Cellular components related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.9SLC18A2, SLC6A3, SNCB, HTR3A
2integral to plasma membraneGO:0058879.0SLC18A2, HTR3A, DRD2, OPRK1, SIGMAR1, SLC6A3

Biological processes related to Cocaine Abuse according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.5SLC6A3, DBH
2adenohypophysis developmentGO:02198410.5SLC6A3, DRD2
3behavioral response to ethanolGO:04814910.4DRD2, DBH
4axon ensheathmentGO:00836610.4PLP1, CLDN11
5deathGO:01626510.4NR4A2, SLC18A2
6regulation of dopamine metabolic processGO:04205310.4NR4A2, SLC6A3
7dopamine biosynthetic processGO:04241610.3SLC6A3, NR4A2
8dopamine metabolic processGO:04241710.3SNCB, DRD2
9response to iron ionGO:01003910.3DRD2, SLC6A3
10response to cocaineGO:04222010.2HTR3A, DRD2, SLC6A3, SLC18A2
11response to painGO:04826510.2SLC6A2, DBH
12cell deathGO:00821910.2PDYN, SIGMAR1, PLP1, SLC6A3
13response to amphetamineGO:00197510.2SLC18A2, DBH, NR4A2, DRD2
14monoamine transportGO:01584410.2SLC6A3, SLC6A4, SLC6A2, SLC18A2
15prepulse inhibitionGO:06013410.2SLC6A3, DRD2
16locomotory behaviorGO:00762610.1DRD2, OPRK1, DBH, SLC6A3, SLC18A2
17circadian regulation of gene expressionGO:0329229.9DRD2, CARTPT
18synaptic transmissionGO:0072689.4SLC18A2, CARTPT, PDYN, HTR3A, OPRK1, SNCB

Molecular functions related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.3SLC6A3, DRD2
2serotonin transmembrane transporter activityGO:01522210.1SLC6A4, SLC18A2
3structural constituent of myelin sheathGO:01991110.1PLP1, MOBP
4monoamine transmembrane transporter activityGO:00850410.0SLC18A2, SLC6A2, SLC6A4, SLC6A3
5drug bindingGO:00814410.0SLC18A2, SLC6A3, SIGMAR1, DRD2
6opioid receptor activityGO:0049859.9SIGMAR1, OPRK1

Products for genes affiliated with Cocaine Abuse

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  • Antibodies
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Sources for Cocaine Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet