MCID: CCN002
MIFTS: 53

Cocaine Abuse malady

Summaries for Cocaine Abuse

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A substance abuse that involves the recurring use of cocaine despite negative consequences.

MalaCards: Cocaine Abuse is related to alcohol abuse and cocaine dependence. An important gene associated with Cocaine Abuse is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Selected targets of CREB1. The compounds gbr 12909 and nisoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, uterus and testes, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Cocaine Abuse

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

cocaine abuse 8 10 44 60


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Disease Ontology8 DOID:809
MeSH34 D019970
SNOMED-CT56 78267003
ICD9CM27 305.6, 305.60

Related Diseases for Cocaine Abuse

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17GeneCards, 18GeneDecks
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Diseases related to Cocaine Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.0SLC6A4, SLC6A3, DRD2
2cocaine dependence31.0SLC18A2, SLC6A4, SLC6A3, PDYN, DRD2, OPRK1
3alcohol dependence30.6SLC6A4, OPRK1, DRD2
4ischemia30.6PDYN, DRD2, OPRK1, NGB, SLC6A3, SLC6A2
5substance abuse30.5DRD2, SLC6A3, SLC6A4
6attention deficit hyperactivity disorder30.4DRD2, DBH, SLC6A3, SLC6A4, SLC6A2
7schizophrenia30.4BCHE, SLC18A2, SLC6A2, SLC6A4, MOBP, PDYN
8personality disorder30.3SLC6A4, SLC6A3, DRD2
9neuroleptic malignant syndrome30.3DRD2
10dementia30.3HTR3A, OPRK1, SNCB, PLP1, SLC6A3, BCHE
11heroin dependence30.1DRD2
12hypertension30.1DBH, SLC6A4
13antisocial personality disorder30.1DRD2, SLC6A3, SLC6A4
14panic disorder30.1SLC6A4, HTR3A
15drug dependence30.1SLC6A4, SLC6A3, OPRK1, DRD2, PDYN
16obesity30.1CARTPT, DRD2, SLC6A3, SLC6A2, BCHE
17migraine30.1HTR3A, DRD2, DBH, SLC6A3, SLC6A4
18bipolar disorder30.1SLC6A4, HTR3A
19pheochromocytoma30.1PDYN, DRD2, DBH, SLC6A3, SLC6A2, SLC18A2
20cerebritis10.5
21opioid abuse10.4
22myocardial infarction10.4
23vasculitis10.4
24neuronitis10.3
25acute myocardial infarction10.3
26dilated cardiomyopathy10.3
27orbital cellulitis10.2
28cellulitis10.2
29wegener's granulomatosis10.2
30cannabis abuse10.2
31priapism10.2
32placental abruption10.2
33atherosclerosis10.2
34esophagitis10.2
35keratitis10.2
36pancreatitis10.2
37thrombocytopenia10.2
38sickle cell disease10.2
39burns10.1
40coronary artery disease10.1
41acute pancreatitis10.1
42antiphospholipid syndrome10.1
43wolff-parkinson-white syndrome10.1
44renal agenesis10.1
45coronary aneurysm10.1
46wound botulism10.1
47hyperprolactinemia10.1
48dependent personality disorder10.1
49intracranial aneurysm10.1
50pharyngitis10.1

Graphical network of the top 20 diseases related to Cocaine Abuse:



Diseases related to cocaine abuse

Clinical Features for Cocaine Abuse

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Drugs & Therapeutics for Cocaine Abuse

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cocaine Abuse

Drug clinical trials:

Search ClinicalTrials for Cocaine Abuse

Search NIH Clinical Center for Cocaine Abuse

Search CenterWatch for Cocaine Abuse

Genetic Tests for Cocaine Abuse

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Anatomical Context for Cocaine Abuse

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32MalaCards
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MalaCards organs/tissues related to Cocaine Abuse:

32
Brain, Uterus, Testes, Placenta, Lung, Pituitary, Thalamus, Cortex, Amygdala, Heart, Skin, Prefrontal cortex

Animal Models for Cocaine Abuse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cocaine Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3CARTPT, HTR3A, DRD2, OPRK1, DBH, CLDN11
2MP:00107719.1PDYN, HTR3A, DRD2, OPRK1, DBH, SLC6A3
3MP:00107688.9DRD2, SNCB, NR4A2, DBH, NGB, PLP1
4MP:00053788.8SNCB, DRD2, HTR3A, PDYN, CARTPT, NR4A2
5MP:00053768.7SNCB, DRD2, HTR3A, PDYN, CARTPT, NR4A2
6MP:00036318.7MOBP, PDYN, HTR3A, DRD2, SNCB, NR4A2
7MP:00053868.3SLC18A2, MOBP, CARTPT, PDYN, HTR3A, DRD2

Publications for Cocaine Abuse

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50PubMed
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Articles related to Cocaine Abuse:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Cocaine abuse and sleep apnea in severe obesity. (23519053)
2013
2
A case-control study of stroke risk factors and outcomes in African American stroke patients with and without crack-cocaine abuse. (20645024)
2012
3
Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors. (22541946)
2012
4
Cocaine abuse in older adults: an underscreened cohort. (20370870)
2010
5
mGluR2-Positive allosteric modulators: Therapeutic potential for treating cocaine abuse? (20711209)
2010
6
Cocaine abuse versus cocaine dependence: cocaine self-administration and pharmacodynamic response in the human laboratory. (19717246)
2010
7
Short- and long-term adverse effects of cocaine abuse during pregnancy on the heart development. (19144667)
2009
8
Haemoperitoneum associated with cocaine abuse: a case report. (18274186)
2007
9
A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. (16537431)
2006
10
Poland-MAPbius syndrome and cocaine abuse: a relook at vascular etiology. (15797189)
2005
11
Investigating the use of contingency management in the treatment of cocaine abuse among individuals with schizophrenia: a feasibility study. (14967553)
2004
12
Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. (12684441)
2003
13
The Rhodococcus sp. cocaine esterase: a bacterial candidate for novel pharmacokinetic-based therapies for cocaine abuse. (14584590)
2003
14
The role of therapeutic alliance in network therapy: a family and peer support-based treatment for cocaine abuse. (12766376)
2003
15
GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). (11931612)
2002
16
Can cocaine abuse exacerbate the cardiac toxicity of human immunodeficiency virus? (11288961)
2001
17
Outpatient cocaine abuse treatment: predictors of success. (11487993)
2001
18
Maternal cocaine abuse resulting in necrotizing enterocolitis. An experimental study in a rat model. II. Results of perfusion studies. (10786976)
2000
19
Altered activity of midbrain dopamine neurons following 7-day withdrawal from chronic cocaine abuse is normalized by D2 receptor stimulation during the early withdrawal phase. (10379527)
1999
20
Brain imaging studies of cocaine abuse: implications for medication development. (10803636)
1999
21
Should cocaine-abusing, buprenorphine-maintained patients receive auricular acupuncture? Findings from an acute effects study. (10630350)
1999
22
Cocaine abuse sharply reduced in an effective methadone maintenance program. (10631964)
1999
23
Moyamoya syndrome associated with cocaine abuse. Case report. (17112210)
1998
24
A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients. (9513631)
1998
25
Intracranial hemorrhage associated with cocaine abuse: a prospective autopsy study. (8628469)
1996
26
Serving infants and families affected by maternal cocaine abuse: Part 1. (9087078)
1996
27
Cardiovascular manifestations of cocaine abuse. A case of recurrent dilated cardiomyopathy. (7774343)
1994
28
Maternal cocaine abuse resulting in necrotizing enterocolitis--an experimental study in a rat model. (8086695)
1994
29
Outpatient treatment for cocaine abuse: a controlled comparison of relapse prevention and twelve-step approaches. (8192128)
1994
30
Index of suspicion. Case 1. Diagnosis: cocaine abuse. (8247971)
1993
31
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. (8101394)
1993
32
Perinatal cocaine abuse as a public health problem. (8374959)
1993
33
A comparison of alternate systems for diagnosing antisocial personality disorder in cocaine abusers. (8320546)
1993
34
The treatment of cocaine abuse. (8316599)
1993
35
Neonatal intestinal ischemia with bowel perforation: an in utero complication of maternal cocaine abuse. (1590129)
1992
36
Papillary muscle rupture after acute myocardial infarction due to cocaine abuse. (1469169)
1992
37
Gastrointestinal complications of cocaine abuse. (1589604)
1992
38
Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. (1985292)
1991
39
Pharmacotherapeutic interventions for cocaine abuse: present practices and future directions. (1685672)
1991
40
Left ventricular hypertrophy associated with chronic cocaine abuse. (1832090)
1991
41
Unrecognized left ventricular dysfunction in an apparently healthy cocaine abuse population. (2347124)
1990
42
Can a technology model of psychotherapy research be applied to cocaine abuse treatment? (2092229)
1990
43
Esophagitis, epiglottitis, and cocaine alkaloid ("crack"): "accidental" poisoning or child abuse? (2359667)
1990
44
Dopaminergic sensitivity and cocaine abuse: response to apomorphine. (2243893)
1990
45
Cocaine abuse among schizophrenic patients. (2386250)
1990
46
The care of infants menaced by cocaine abuse. (2507857)
1989
47
Intracerebral hemorrhage associated with cocaine abuse. (2742464)
1989
48
Personality risk factors for cocaine abuse. (2735482)
1989
49
Placental abruption associated with cocaine abuse. (3285653)
1988
50
Cocaine and heroin dependence compared in poly-drug abusers. (3354742)
1988

Genetic Variations for Cocaine Abuse

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Expression for genes affiliated with Cocaine Abuse

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Abuse

Search GEO for disease gene expression data for Cocaine Abuse.

Pathways for genes affiliated with Cocaine Abuse

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Sources:
49PharmGKB, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Cocaine Abuse

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Cocaine Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1gbr 129094410.3SLC6A2, SLC6A3, SLC6A4, SLC18A2
2nisoxetine44 2811.3SLC18A2, SLC6A2, SLC6A4, SLC6A3
3tropane4410.3SLC18A2, SLC6A2, SLC6A4, SLC6A3
4d amphetamine4410.2SLC6A2, SLC6A4, SLC6A3, DRD2
5maoa4410.2SLC6A2, SLC6A4, DBH, SLC6A3, DRD2
6mazindol44 28 1112.2SLC6A3, SLC6A4, SLC6A2, SLC18A2
73,4-Methylenedioxymethamphetamine1110.2SLC6A4, SLC6A3, SLC6A2, SLC18A2
8milnacipran44 49 1112.2SLC18A2, SLC6A2, SLC6A3, SLC6A4
9tyramine44 28 2412.2SLC6A2, SLC6A4, SLC6A3, DBH, BCHE
10MMDA1110.2SLC6A3, SLC18A2, SLC6A2, SLC6A4
11methylphenidate44 49 1112.2SLC6A4, SLC18A2, SLC6A2, SLC6A3, DRD2
12Tapentadol1110.2HTR3A, SLC6A2, SLC6A4, OPRK1
13reboxetine44 28 1112.2SLC6A3, SLC6A4, SLC18A2, SLC6A2
14heroin44 49 1112.1PDYN, SLC6A3, DRD2, OPRK1, SLC6A4, BCHE
15duloxetine44 49 28 1113.1SLC6A4, SLC6A3, SLC18A2, SLC6A2
16ephedrine28 44 1112.1SLC6A3, SLC6A2, SLC18A2, BCHE
17venlafaxine49 44 11 2413.1SLC18A2, SLC6A2, SLC6A4, SLC6A3, HTR3A
18amitriptyline44 49 28 1113.1OPRK1, SLC6A2, SLC6A4, HTR3A, SLC6A3, BCHE
19opiate4410.1SLC6A3, DBH, OPRK1, PDYN, DRD2, SLC6A4
20bupropion44 49 11 2413.1SLC6A3, SLC18A2, SLC6A2, SLC6A4, DRD2
216-hydroxydopamine4410.1PDYN, SLC6A3, NR4A2, DBH, SLC6A2, DRD2
22indole4410.1HTR3A, OPRK1, SIGMAR1, SLC6A4, SLC18A2
23mdma4410.1SLC6A3, SLC18A2, SLC6A2, SLC6A4
24Ephedra1110.1SLC6A2, SLC6A3, SLC18A2, SLC6A4
25maprotiline44 1111.1SLC6A4, SLC6A2, HTR3A, SLC6A3
26paroxetine44 49 28 1113.1SLC6A3, SLC6A4, HTR3A, SLC18A2, SLC6A2
27fluoxetine49 44 28 1113.0SLC6A3, SLC18A2, SLC6A2, SLC6A4, DRD2, HTR3A
28escitalopram44 49 11 2413.0SLC6A3, SLC18A2, SLC6A4, SLC6A2
29mptp4410.0SLC6A4, DRD2, SLC18A2, SLC6A2, SLC6A3, DBH
30nmda44 2811.0SLC6A3, OPRK1, PDYN, BCHE
31methamphetamine44 49 1112.0SLC6A3, DRD2, SLC6A2, SLC18A2, SLC6A4, PDYN
32imipramine44 49 28 11 2414.0DBH, SLC6A3, SLC6A4, SLC6A2, SLC18A2, HTR3A
33spec-t4410.0DRD2, SLC18A2, SLC6A4, SLC6A2, SLC6A3
34levodopa44 1111.0PDYN, DRD2, DBH, SLC6A3, SLC18A2, OPRK1
35nefazodone44 49 1111.9SLC6A4, SLC6A2, SLC6A3, HTR3A
36amine449.9SLC6A2, BCHE, SLC18A2, SLC6A4, DBH, OPRK1
375-hydroxytryptamine449.9SLC18A2, SLC6A2, SLC6A4, DBH, HTR3A, SLC6A3
38haloperidol44 28 2 49 1113.9SLC18A2, SLC6A2, SLC6A4, SLC6A3, DRD2, HTR3A
39citalopram49 44 11 2412.9SLC18A2, HTR3A, SLC6A2, SLC6A3, SLC6A4
40reserpine44 28 1111.9DRD2, SLC6A3, SLC6A2, SLC18A2
41trimipramine49 44 1111.9DRD2, SLC6A2, SLC6A4, SLC6A3
42amphetamine44 1110.8SLC18A2, SLC6A2, SLC6A4, SLC6A3, OPRK1, PDYN
43sulpiride44 28 1111.7BCHE, SLC6A3, DRD2, PDYN
44nicotine44 49 28 1112.6SLC6A2, DBH, SLC18A2, BCHE, SLC6A4, OPRK1
45glutamate449.4BCHE, SLC18A2, SLC6A2, SLC6A4, DBH, SLC6A3
46gaba449.4SLC6A3, SLC6A4, SLC6A2, SLC18A2, PLP1, DBH
47acetylcholine44 49 28 11 2413.4PDYN, HTR3A, DRD2, OPRK1, DBH, PLP1
48norepinephrine44 11 2411.4PDYN, HTR3A, DRD2, OPRK1, NR4A2, DBH
49dopamine44 28 11 2412.2SLC18A2, CARTPT, PDYN, HTR3A, DRD2, OPRK1
50cocaine44 1110.1PDYN, DRD2, OPRK1, DBH, BCHE, SLC18A2

GO Terms for genes affiliated with Cocaine Abuse

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16Gene Ontology
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Cellular components related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.9SLC18A2, SLC6A3, SNCB, HTR3A
2integral to plasma membraneGO:0058879.0SLC18A2, HTR3A, DRD2, OPRK1, SIGMAR1, SLC6A3

Biological processes related to Cocaine Abuse according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.5SLC6A3, DBH
2adenohypophysis developmentGO:02198410.5SLC6A3, DRD2
3behavioral response to ethanolGO:04814910.4DRD2, DBH
4axon ensheathmentGO:00836610.4PLP1, CLDN11
5deathGO:01626510.4NR4A2, SLC18A2
6regulation of dopamine metabolic processGO:04205310.4NR4A2, SLC6A3
7dopamine biosynthetic processGO:04241610.3SLC6A3, NR4A2
8dopamine metabolic processGO:04241710.3SNCB, DRD2
9response to iron ionGO:01003910.3DRD2, SLC6A3
10response to cocaineGO:04222010.2HTR3A, DRD2, SLC6A3, SLC18A2
11response to painGO:04826510.2SLC6A2, DBH
12cell deathGO:00821910.2PDYN, SIGMAR1, PLP1, SLC6A3
13response to amphetamineGO:00197510.2SLC18A2, DBH, NR4A2, DRD2
14monoamine transportGO:01584410.2SLC6A3, SLC6A4, SLC6A2, SLC18A2
15prepulse inhibitionGO:06013410.2SLC6A3, DRD2
16locomotory behaviorGO:00762610.1DRD2, OPRK1, DBH, SLC6A3, SLC18A2
17circadian regulation of gene expressionGO:0329229.9DRD2, CARTPT
18synaptic transmissionGO:0072689.4SLC18A2, CARTPT, PDYN, HTR3A, OPRK1, SNCB

Molecular functions related to Cocaine Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.3SLC6A3, DRD2
2serotonin transmembrane transporter activityGO:01522210.1SLC6A4, SLC18A2
3structural constituent of myelin sheathGO:01991110.1PLP1, MOBP
4monoamine transmembrane transporter activityGO:00850410.0SLC18A2, SLC6A2, SLC6A4, SLC6A3
5drug bindingGO:00814410.0SLC18A2, SLC6A3, SIGMAR1, DRD2
6opioid receptor activityGO:0049859.9SIGMAR1, OPRK1

Products for genes affiliated with Cocaine Abuse

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  • Antibodies
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Sources for Cocaine Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet