MCID: CCN001
MIFTS: 48

Cocaine Dependence

Categories: Mental diseases

Aliases & Classifications for Cocaine Dependence

Summaries for Cocaine Dependence

Disease Ontology : 12 A drug dependence that is a psychological dependency on the regular use of cocaine.

MalaCards based summary : Cocaine Dependence is related to antisocial personality disorder and schizophrenia. An important gene associated with Cocaine Dependence is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Transmission across Chemical Synapses. The drugs Biperiden and Cocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 72 Cocaine dependence is a psychological desire to use cocaine regularly. Cocaine overdose may result in... more...

Related Diseases for Cocaine Dependence

Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 antisocial personality disorder 31.0 DRD2 DRD3
2 schizophrenia 29.2 DBH DRD2 DRD3 PRL SLC6A3 SLC6A4
3 personality disorder 28.7 DRD2 DRD3 OPRM1 PDYN POMC SLC6A3
4 heroin dependence 25.9 CHRNA3 CHRNA5 DRD2 DRD3 OPRK1 OPRM1
5 cocaine intoxication 10.9
6 placenta disease 10.7 DRD2 DRD3
7 dissociative disorder 10.7 DRD3 SLC6A4
8 rhinoscleroma 10.7 DRD2 PRL
9 teebi kaurah syndrome 10.7 DRD2 DRD3
10 water-clear cell adenoma 10.7 DRD2 PRL
11 hyperthyroxinemia 10.7 DRD2 SLC6A4
12 peroxisomal biogenesis disorders 10.6 DRD2 PRL
13 anodontia 10.6 SLC6A3 SLC6A4
14 pompholyx 10.6 DRD2 SLC6A4
15 african histoplasmosis 10.6 POMC PRL
16 anosognosia 10.6 DRD2 SLC6A4
17 aortic valve atresia 10.6 POMC PRL
18 intermittent squint 10.5 POMC PRL
19 lymphoepithelioma-like carcinoma 10.5 POMC PRL
20 olfactory nerve neoplasm 10.5 POMC PRL
21 tinea pedis 10.5 SLC6A3 SLC6A4
22 osteoclast-like giant cell neoplasm of the pancreas 10.5 POMC PRL
23 vertebral artery occlusion 10.5 POMC PRL
24 intracranial cavernous angioma 10.5 DRD2 SLC6A3 SLC6A4
25 splenic abscess 10.5 DRD2 SLC6A3 SLC6A4
26 lactic acidosis 10.5 POMC PRL
27 asperger syndrome 10.5 DRD2 DRD3 SLC6A3
28 tongue disease 10.5 DRD2 SLC6A3 SLC6A4
29 actinobacillosis 10.5 POMC PRL
30 ganglioneuroma 10.5 DRD2 DRD3 SLC6A3
31 ulcerative blepharitis 10.5 POMC PRL
32 hepatitis d 10.5 DRD2 SLC6A3 SLC6A4
33 psychotic disorder 10.5
34 protein s deficiency 10.5 POMC PRL
35 ornithosis 10.5 DRD2 PRL SLC6A4
36 contact dermatitis 10.5 DRD2 SLC6A3
37 simpson-golabi-behmel syndrome 10.4 DBH DRD2 SLC6A3
38 rhabdoid cancer 10.4 PDYN POMC
39 hypothyroidism, congenital, nongoitrous 4 10.4 POMC PRL
40 parietal foramina 3 10.4 DBH DRD2 SLC6A3
41 albinism, oculocutaneous, type v 10.4 DRD2 DRD3 SLC6A4
42 immune system organ benign neoplasm 10.4 POMC PRL
43 osteogenesis imperfecta, type ix 10.4 DBH DRD2 SLC6A3
44 pelvic inflammatory disease 10.4 DBH DRD2 SLC6A4
45 uterus intravascular leiomyomatosis 10.4 OPRK1 SLC6A4
46 renpenning syndrome 10.4 DBH SLC6A4
47 retinitis pigmentosa 46 10.4 POMC PRL
48 strabismus 10.3 DRD2 POMC PRL
49 cold-induced sweating syndrome 2 10.3 DRD2 POMC PRL
50 alpha-methylacyl-coa racemase deficiency 10.3 DRD2 POMC PRL

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to Cocaine Dependence

Symptoms & Phenotypes for Cocaine Dependence

MGI Mouse Phenotypes related to Cocaine Dependence:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 CHRNA5 CHRNB3 DBH DRD2 DRD3 OPRK1
2 endocrine/exocrine gland MP:0005379 9.92 DBH DRD2 OPRK1 OPRM1 POMC PRL
3 adipose tissue MP:0005375 9.91 DBH DRD2 DRD3 OPRM1 PDYN POMC
4 growth/size/body region MP:0005378 9.91 CHRNA3 DBH DRD2 DRD3 OPRM1 PDYN
5 homeostasis/metabolism MP:0005376 9.9 CHRNA3 DBH DRD2 DRD3 OPRK1 OPRM1
6 digestive/alimentary MP:0005381 9.85 CHRNA3 DRD2 DRD3 OPRK1 OPRM1 PDYN
7 integument MP:0010771 9.61 POMC PRL SLC6A3 SLC6A4 DBH DRD2
8 nervous system MP:0003631 9.4 CHRNA3 CHRNA5 DBH DRD2 DRD3 OPRK1

Drugs & Therapeutics for Cocaine Dependence

Drugs for Cocaine Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 334)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Biperiden Approved Phase 4,Phase 3,Phase 2 514-65-8 2381
2
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-36-2 5760 446220
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
4
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
5
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
6
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
7
Methamphetamine Approved, Illicit Phase 4,Phase 3,Phase 2 537-46-2 10836
8
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
9
Amphetamine Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 300-62-9 5826 3007
10
Risperidone Approved, Investigational Phase 4,Phase 2,Phase 1 106266-06-2 5073
11
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
12
Methadone Approved Phase 4,Phase 2,Phase 3,Phase 1 76-99-3 4095
13
Lamotrigine Approved, Investigational Phase 4,Phase 2 84057-84-1 3878
14
Azacitidine Approved, Investigational Phase 4 320-67-2 9444
15
Carbamazepine Approved, Investigational Phase 4,Phase 2 298-46-4 2554
16
Bupropion Approved Phase 4,Phase 3,Phase 2,Early Phase 1 34841-39-9, 34911-55-2 444
17
Nicotine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 54-11-5 942 89594
18
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 616-91-1 12035
19
Heroin Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 561-27-3 5462328
20
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-56-6 439302 53477758
21
Disulfiram Approved Phase 4,Phase 2,Phase 1 97-77-8 3117
22
Caffeine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-08-2 2519
23
Choline Approved, Nutraceutical Phase 4,Phase 3 62-49-7 305
24
Glutamic Acid Approved, Nutraceutical Phase 4,Phase 1,Early Phase 1 56-86-0 33032
25 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antiparkinson Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
29 Biperiden lactate Phase 4,Phase 3,Phase 2
30 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Central Nervous System Stimulants Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
32 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Cholinergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
34 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Dopamine Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Muscarinic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Parasympatholytics Phase 4,Phase 3,Phase 2,Phase 1
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 Phosphodiesterase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
42 Purinergic P1 Receptor Antagonists Phase 4,Phase 2,Phase 3,Phase 1
43 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Anti-Anxiety Agents Phase 4,Phase 2,Phase 1
45 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1
46 Antiemetics Phase 4,Phase 2,Phase 1
47 Antipruritics Phase 4,Phase 2
48 Antipsychotic Agents Phase 4,Phase 2,Phase 1,Early Phase 1
49 Dermatologic Agents Phase 4,Phase 2
50 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 371)

id Name Status NCT ID Phase Drugs
1 Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence Unknown status NCT00495183 Phase 4 caffeine;Biperiden;Placebo
2 Pharmacologic MRI in Cocaine Addiction Unknown status NCT01652378 Phase 4 ondansetron, lidocaine
3 Citicoline for Bipolar 1 Disorder and Cocaine Dependence Completed NCT00619723 Phase 4 Citicoline;Placebo
4 An Add-On Trial of Quetiapine in Patients With Bipolar Disorder and Cocaine Dependence Completed NCT00223210 Phase 4 Quetiapine;PLacebo
5 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed NCT00280293 Phase 4 Lamotrigine;Placebo
6 Pathophysiological Subtyping of Abnormalities in Cocaine Dependence - 9 Completed NCT00015275 Phase 4
7 Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction Completed NCT02626494 Phase 4 N-Acetylcystein;Placebo
8 Quetiapine for Cocaine Use and Cravings Completed NCT00232336 Phase 4 quetiapine
9 Pharmacotherapy and Intensive Treatment - 2 Completed NCT00000218 Phase 4 Carbamazepine
10 Effects of Modafinil in Methamphetamine Dependence Completed NCT00751023 Phase 4 Modafinil;Placebo
11 Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia Completed NCT00208143 Phase 4 Quetiapine;Risperidone
12 The Maternal Lifestyle Study (MLS) Completed NCT00059540 Phase 4
13 Brain Changes in Stimulant Dependent Subjects - 8 Completed NCT00000343 Phase 4
14 Bupropion for ADHD in Adolescents With Substance Use Disorder Completed NCT00936299 Phase 4 Bupropion
15 Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial. Recruiting NCT03018236 Phase 4 Alcohol N-acetylcysteine;Alcohol Placebo;Cocaine N-acetylcysteine;Cocaine Placebo
16 Oxytocin and Cognitive Behavioral Therapy in Drug Dependence Terminated NCT00975416 Phase 4 Intranasal Oxytocin;Placebo
17 A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts Withdrawn NCT02134002 Phase 4 Disulfiram;Placebo
18 Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1 Unknown status NCT00249691 Phase 3 Topiramate + Cognitive Behavioral Therapy;Placebo + Cognitive Behavioral Therapy
19 Novel Pharmacotherapy for Dual Dependence Unknown status NCT00448825 Phase 3 Topiramate + Cognitive Behavioral Therapy;Placebo + Cognitive Behavioral Therapy
20 Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence Completed NCT01811940 Phase 2, Phase 3 Adderall-ER;Topiramate
21 Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence Completed NCT01468012 Phase 2, Phase 3 levodopa carbidopa and entacapone (LCE);Placebo
22 Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1 Completed NCT00032929 Phase 3 Selegiline
23 Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence Completed NCT00553319 Phase 2, Phase 3 Placebo;Adderall-XR;Adderall-XR
24 Brain Imaging Study of the Effects of Modafinil in Cocaine Addiction Completed NCT00701532 Phase 3 Modafinil and PET (brain imaging);placebo
25 Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence Completed NCT00167232 Phase 3 Naltrexone
26 Dose Response Trial of Pergolide for Cocaine Dependence - 1 Completed NCT00000248 Phase 3 Pergolide
27 Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1 Completed NCT00218660 Phase 3 Naltrexone;Placebo
28 Vigabatrin for the Treatment of Cocaine Dependency Completed NCT01281202 Phase 2, Phase 3 Vigabatrin;Matching Placebo
29 Adaptive Treatment for Alcohol and Cocaine Dependence Completed NCT01032135 Phase 2, Phase 3 medication management
30 Cocaine Use Reduction With Buprenorphine Completed NCT01402492 Phase 2, Phase 3 Buprenorphine + Naltrexone;Placebo + Naltrexone
31 Cocaine/Crack and Reduction of Compulsion With Biperiden Completed NCT01251393 Phase 3 Biperiden;Placebo
32 Progesterone Treatment for Cocaine-dependent Women: A Pilot Study Completed NCT00632099 Phase 2, Phase 3 Oral micronized progesterone;Placebo
33 Clinical Neurobiology of Serotonin and Addiction Completed NCT00732901 Phase 2, Phase 3 Escitalopram;Placebo
34 Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients Completed NCT00495092 Phase 2, Phase 3 Caffeine;Biperiden;Placebo
35 Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10 Completed NCT00000293 Phase 3 Nefazodone
36 Smoking-Cessation and Stimulant Treatment (S-CAST) Completed NCT01077024 Phase 3
37 Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1 Completed NCT00061087 Phase 2, Phase 3 Methylphenidate;Bupropion
38 Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence Completed NCT00223236 Phase 3 Citicoline;Placebo
39 An Eval of Neurocognitive Function, Oxidative Damage, and Their Association With Outcomes in METH and Cocaine Abusers. Completed NCT00628927 Phase 3
40 The German Project of Heroin Assisted Treatment of Opiate Dependent Patients Completed NCT00268814 Phase 3 Diacetylmorphine;Methadone
41 Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence Recruiting NCT02111798 Phase 2, Phase 3 Bupropion XL;placebo
42 Change the Cycle: An RCT to Prevent Injection Initiation Recruiting NCT02774954 Phase 3
43 Investigation of Mifepristone (RU486) on Stress Sensitivity and Relapse Prevention in Cocaine Dependent Patients Active, not recruiting NCT01134198 Phase 2, Phase 3 Mifepristone;placebo
44 Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients. Active, not recruiting NCT02255357 Phase 2, Phase 3 Placebo;Intranasal Oxytocin
45 Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence Unknown status NCT00123383 Phase 2 Modafinil
46 A Double-Blind, Controlled Study of Aripiprazole in Co-Morbid Schizophrenia and Cocaine Dependence Unknown status NCT00737256 Phase 2 Aripiprazole;Perphenazine
47 Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence Unknown status NCT01397266 Phase 2
48 Treating Cocaine Abuse: A Behavioral Approach Unknown status NCT01822327 Phase 2
49 Effects of Repeated Transcranial Magnetic Stimulation (rTMS) on the Treatment of Cocaine Addicted Patients Unknown status NCT01259362 Phase 2
50 Repetitive Transcranial Magnetic Stimulation in Symptoms of Attention Deficit Hyperactivity Disorder and Cognitive Function In Cocaine Addicts Unknown status NCT01593982 Phase 2

Search NIH Clinical Center for Cocaine Dependence

Genetic Tests for Cocaine Dependence

Anatomical Context for Cocaine Dependence

MalaCards organs/tissues related to Cocaine Dependence:

39
Brain, Heart, Testes, Cortex, Prefrontal Cortex, Pituitary, Thalamus

Publications for Cocaine Dependence

Articles related to Cocaine Dependence:

(show top 50) (show all 611)
id Title Authors Year
1
Neurostimulation techniques in the treatment of cocaine dependence: A review of the literature. ( 28822321 )
2018
2
Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence. ( 28823835 )
2017
3
Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence. ( 28857070 )
2017
4
Cocaine dependence modulates the effect of HIV infection on brain activation during intertemporal decision making. ( 28711810 )
2017
5
Functional neural changes following behavioral therapies and disulfiram for cocaine dependence. ( 28714728 )
2017
6
Kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms? ( 27885412 )
2017
7
Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. ( 28251596 )
2017
8
Reply to: kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms? ( 27896378 )
2017
9
A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence. ( 28190084 )
2017
10
A Novel Therapy for cocaine dependence during abstinence: A randomized clinical trial. ( 28894547 )
2017
11
Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence. ( 28074533 )
2017
12
Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis. ( 28350194 )
2017
13
Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users. ( 26833821 )
2016
14
Psychiatric comorbidity in a sample of cocaine-dependent outpatients seen in the Community of Madrid drug addiction care network. ( 26990385 )
2016
15
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. ( 26817621 )
2016
16
Psychostimulant drugs for cocaine dependence. ( 27670244 )
2016
17
Polysomnographic measures of sleep in cocaine dependence and alcohol dependence: Implications for age-related loss of slow wave, stage 3 sleep. ( 26749502 )
2016
18
Attenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences. ( 27441590 )
2016
19
Psychotic symptoms associated with the use of dopaminergic drugs, in patients with cocaine dependence or abuse. ( 27009114 )
2016
20
Effective drug therapy for cocaine dependence: a milestone. ( 27015910 )
2016
21
Modafinil and sleep architecture in an inpatient-outpatient treatment study of cocaine dependence. ( 26777774 )
2016
22
Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users. ( 27499362 )
2016
23
Crack-cocaine dependence and aging: effects on working memory. ( 27111700 )
2016
24
Successful classification of cocaine dependence using brain imaging: a generalizable machine learning approach. ( 27766943 )
2016
25
Clinical differences between cocaine-dependent patients with and without antisocial personality disorder. ( 27839828 )
2016
26
A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. ( 27498889 )
2016
27
Mixed-amphetamine salts increase abstinence from marijuana in patients with co-occurring attention-deficit/hyperactivity disorder and cocaine dependence. ( 28051838 )
2016
28
Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders: Impulsivity Dimensions as Predictors of Current Cocaine Dependence. ( 27014100 )
2016
29
A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. ( 27449273 )
2016
30
Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence. ( 27394932 )
2016
31
Effect of Continuing Care for Cocaine Dependence on HIV Sex-Risk Behaviors. ( 27224980 )
2016
32
Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. ( 26792441 )
2016
33
Just showing up is not enough: Homework adherence and outcome in cognitive-behavioral therapy for cocaine dependence. ( 27454780 )
2016
34
Cocaine dependence and thalamic functional connectivity: a multivariate pattern analysis. ( 27556009 )
2016
35
Buprenorphinea88+a88Naloxone plus Naltrexone for the Treatment of Cocaine Dependence: The Cocaine Use Reduction with Buprenorphine (CURB) Study. ( 26948856 )
2016
36
Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases. ( 26792050 )
2016
37
Assessing the effects of cocaine dependence and pathological gambling using group-wise sparse representation of natural stimulus FMRI data. ( 27704410 )
2016
38
Dissociable Effects of Cocaine-Dependence on Reward Processes: The Role of Acute Cocaine and Craving. ( 27545986 )
2016
39
Topiramate for Cocaine Dependence: A Systematic Review and Meta-Analysis of Randomized Control Trials. ( 26826006 )
2016
40
Antipsychotic medications for cocaine dependence. ( 26992929 )
2016
41
Efficacy of topiramate in the treatment of crack cocaine dependence: a double-blind, randomized, placebo-controlled trial. ( 27046312 )
2016
42
Increased corticolimbic connectivity in cocaine dependence versus pathological gambling is associated with drug severity and emotion-related impulsivity. ( 25818325 )
2015
43
In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence. ( 26080087 )
2015
44
A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline for Cocaine Dependence in Bipolar I Disorder. ( 25998279 )
2015
45
Cocaine dependence and stroke: pathogenesis and management. ( 25742568 )
2015
46
Impaired Bayesian learning for cognitive control in cocaine dependence. ( 25869543 )
2015
47
Modafinil in the treatment of crack-cocaine dependence in the Netherlands: Results of an open-label randomised controlled feasibility trial. ( 25922424 )
2015
48
Effects of adverse childhood experiences on the association between intranasal oxytocin and social stress reactivity among individuals with cocaine dependence. ( 26231584 )
2015
49
Integrative Bayesian Analysis of Neuroimaging-Genetic Data with Application to Cocaine Dependence. ( 26484829 )
2015
50
WITHDRAWN: Anticonvulsants for cocaine dependence. ( 25731153 )
2015

Variations for Cocaine Dependence

Expression for Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for Cocaine Dependence

Pathways related to Cocaine Dependence according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 CHRNA3 CHRNA5 CHRNB3 DRD2 DRD3 OPRK1
2
Show member pathways
12.51 CHRNA3 CHRNA5 CHRNB3 SLC6A3 SLC6A4
3
Show member pathways
12.37 CHRNA3 DRD2 DRD3 SLC6A3
4
Show member pathways
11.57 DRD2 PDYN SLC6A3
5
Show member pathways
11.27 CHRNA3 CHRNA5 DRD2 DRD3
6
Show member pathways
10.97 DBH SLC6A3 SLC6A4
7
Show member pathways
10.86 SLC6A3 SLC6A4
8 10.77 DRD2 DRD3

GO Terms for Cocaine Dependence

Cellular components related to Cocaine Dependence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 DRD2 DRD3 OPRK1 OPRM1 SLC6A3 SLC6A4
2 synapse GO:0045202 9.78 CHRNA3 CHRNA5 CHRNB3 OPRK1
3 neuronal cell body GO:0043025 9.71 CHRNA3 OPRK1 PDYN SLC6A3
4 dendrite GO:0030425 9.55 CHRNA3 DRD2 OPRK1 OPRM1 PDYN
5 perikaryon GO:0043204 9.54 DRD2 OPRK1 OPRM1
6 axon terminus GO:0043679 9.43 DRD2 OPRK1 PDYN
7 neuron projection GO:0043005 9.35 CHRNB3 OPRK1 OPRM1 SLC6A3 SLC6A4
8 acetylcholine-gated channel complex GO:0005892 8.8 CHRNA3 CHRNA5 CHRNB3
9 integral component of membrane GO:0016021 10.16 CHRNA3 CHRNA5 CHRNB3 DBH DRD2 DRD3
10 plasma membrane GO:0005886 10.02 CHRNA3 CHRNA5 CHRNB3 DRD2 DRD3 OPRK1

Biological processes related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.96 DRD2 DRD3 SLC6A3 SLC6A4
2 chemical synaptic transmission GO:0007268 9.88 CHRNA5 DBH OPRK1 OPRM1 PDYN
3 neuropeptide signaling pathway GO:0007218 9.81 OPRK1 OPRM1 PDYN POMC
4 visual learning GO:0008542 9.77 DBH DRD2 DRD3
5 negative regulation of adenylate cyclase activity GO:0007194 9.74 DRD2 DRD3 OPRM1
6 negative regulation of blood pressure GO:0045776 9.71 DRD2 DRD3
7 regulation of sensory perception of pain GO:0051930 9.71 OPRK1 OPRM1
8 regulation of multicellular organism growth GO:0040014 9.71 DRD3 PRL
9 associative learning GO:0008306 9.71 DBH DRD2
10 synaptic transmission, cholinergic GO:0007271 9.71 CHRNA3 CHRNA5 CHRNB3
11 excitatory postsynaptic potential GO:0060079 9.71 CHRNA3 CHRNA5 CHRNB3 OPRM1
12 eating behavior GO:0042755 9.7 OPRK1 OPRM1
13 neuromuscular synaptic transmission GO:0007274 9.7 CHRNA5 CHRNB3
14 arachidonic acid secretion GO:0050482 9.7 DRD2 DRD3
15 regulation of dopamine secretion GO:0014059 9.7 DRD2 DRD3
16 response to amphetamine GO:0001975 9.7 DBH DRD2 DRD3
17 dopamine receptor signaling pathway GO:0007212 9.69 DRD2 DRD3
18 response to iron ion GO:0010039 9.69 DRD2 SLC6A3
19 synaptic transmission, dopaminergic GO:0001963 9.69 DRD2 DRD3
20 negative regulation of protein secretion GO:0050709 9.68 DRD2 DRD3
21 estrous cycle GO:0044849 9.68 OPRK1 OPRM1
22 dopamine metabolic process GO:0042417 9.68 DRD2 DRD3
23 neurotransmitter biosynthetic process GO:0042136 9.68 SLC6A3 SLC6A4
24 maternal behavior GO:0042711 9.67 DBH OPRK1
25 ammonium transmembrane transport GO:0072488 9.67 SLC6A3 SLC6A4
26 positive regulation of renal sodium excretion GO:0035815 9.67 DRD2 DRD3
27 behavioral response to cocaine GO:0048148 9.67 DRD2 DRD3 OPRK1
28 G-protein coupled receptor internalization GO:0002031 9.66 DRD2 DRD3
29 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.65 DRD2 DRD3
30 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.65 DRD3 OPRM1
31 adenohypophysis development GO:0021984 9.65 DRD2 SLC6A3
32 response to ethanol GO:0045471 9.65 DRD2 DRD3 OPRK1 OPRM1 SLC6A3
33 monoamine transport GO:0015844 9.64 SLC6A3 SLC6A4
34 behavioral response to nicotine GO:0035095 9.64 CHRNA3 CHRNA5
35 dopamine catabolic process GO:0042420 9.63 DBH SLC6A3
36 opioid receptor signaling pathway GO:0038003 9.63 OPRK1 OPRM1
37 behavioral response to ethanol GO:0048149 9.63 DBH DRD2 OPRM1
38 dopamine uptake involved in synaptic transmission GO:0051583 9.62 SLC6A3 SLC6A4
39 regulation of cAMP metabolic process GO:0030814 9.62 DRD2 DRD3
40 response to nicotine GO:0035094 9.62 CHRNA5 CHRNB3 DRD2 SLC6A3
41 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.61 DRD2 DRD3
42 sensory perception GO:0007600 9.61 OPRK1 OPRM1 PDYN
43 negative regulation of dopamine receptor signaling pathway GO:0060160 9.59 DRD2 DRD3
44 acid secretion GO:0046717 9.58 DRD2 DRD3
45 response to histamine GO:0034776 9.58 DRD2 DRD3
46 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.56 OPRK1 OPRM1
47 regulation of locomotion involved in locomotory behavior GO:0090325 9.55 DRD2 DRD3
48 prepulse inhibition GO:0060134 9.54 DRD2 DRD3 SLC6A3
49 response to morphine GO:0043278 9.46 DRD2 DRD3 OPRK1 OPRM1
50 response to cocaine GO:0042220 9.35 DRD2 DRD3 OPRK1 OPRM1 SLC6A3

Molecular functions related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 extracellular ligand-gated ion channel activity GO:0005230 9.58 CHRNA3 CHRNA5 CHRNB3
2 neuropeptide binding GO:0042923 9.54 OPRK1 OPRM1
3 neurotransmitter:sodium symporter activity GO:0005328 9.52 SLC6A3 SLC6A4
4 acetylcholine receptor activity GO:0015464 9.51 CHRNA3 CHRNA5
5 ligand-gated ion channel activity GO:0015276 9.5 CHRNA3 CHRNA5 CHRNB3
6 opioid receptor activity GO:0004985 9.49 OPRK1 OPRM1
7 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.48 DRD2 DRD3
8 monoamine transmembrane transporter activity GO:0008504 9.46 SLC6A3 SLC6A4
9 dopamine neurotransmitter receptor activity GO:0004952 9.43 DRD2 DRD3
10 acetylcholine binding GO:0042166 9.43 CHRNA3 CHRNA5 CHRNB3
11 dopamine:sodium symporter activity GO:0005330 9.37 SLC6A3 SLC6A4
12 acetylcholine-gated cation-selective channel activity GO:0022848 9.33 CHRNA3 CHRNA5 CHRNB3
13 drug binding GO:0008144 9.26 CHRNB3 DRD2 DRD3 SLC6A3
14 neuropeptide hormone activity GO:0005184 9.25 PDYN
15 dopamine binding GO:0035240 8.8 DRD2 DRD3 SLC6A3

Sources for Cocaine Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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