MCID: CCN001
MIFTS: 56

Cocaine Dependence malady

Summaries for Cocaine Dependence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine overdose... more...

MalaCards: Cocaine Dependence is related to alcohol dependence and drug dependence. An important gene associated with Cocaine Dependence is PDYN (prodynorphin), and among its related pathways are Dopamine receptors and Monoamine Transport. The compounds u50488 and nmda have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related mouse phenotypes are taste/olfaction and adipose tissue.

Disease Ontology:8 A drug dependence that is a psychological dependency on the regular use of cocaine.

Aliases & Classifications for Cocaine Dependence

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

cocaine dependence 8 10 44 60


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Disease Ontology8 DOID:9975
ICD9CM27 304.20, 304.2
NCIt39 C34492
MeSH34 D019970

Related Diseases for Cocaine Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.0DRD2, GABRA2, SLC6A4, ANKK1, OPRM1, OPRK1
2drug dependence31.0OPRK1, OPRM1, SLC6A3, SLC6A4, PDYN, DRD2
3heroin dependence30.8DRD2, ANKK1
4personality disorder30.8DRD2, SLC6A4, DRD3, SLC6A3
5cocaine abuse30.8DRD2, OPRK1, DBH, SLC6A3, SLC6A4
6antisocial personality disorder30.6ANKK1, SLC6A3, SLC6A4, DRD2
7schizophrenia30.6CALY, PDYN, DBH, SLC6A3, SLC6A4, DRD2
8bipolar disorder30.6DRD2, SLC6A4
9opiate dependence30.6OPRM1
10substance dependence30.5OPRM1, SLC6A3, SLC6A4, DRD2, PDYN, DRD3
11nicotine dependence30.4SLC6A4, ANKK1, DRD2
12attention deficit hyperactivity disorder30.3DRD2, DBH, SLC6A4, SLC6A3, SLC18A2
13alexithymia30.0ANKK1
14pathological gambling30.0DRD3, DRD2, SLC6A3
15schizoaffective disorder30.0SLC6A4, DRD2, DRD3
16ischemia30.0DRD2, PDYN, SLC6A3, OPRK1
17alcohol abuse30.0SLC6A3, OPRM1, DRD3, DRD2, SLC6A4
18mood disorder30.0DBH, DRD3, POMC, SLC18A2, SLC6A3, SLC6A4
19dependent personality disorder10.6
20cannabis dependence10.5
21cerebritis10.3
22post-traumatic stress disorder10.2
23major depressive disorder10.0
24borderline personality disorder10.0
25cannabis abuse10.0
26bipolar i disorder10.0
27congenital syphilis10.0
28hyperthyroidism10.0
29prostatitis10.0
30sexual disorder10.0
31syphilis10.0
32restless legs syndrome10.0DRD2
33bulimia nervosa10.0SLC6A4
34eating disorder10.0SLC6A4
35prion disease10.0POMC
36neuroleptic malignant syndrome10.0DRD2
37fibromyalgia10.0SLC6A4
38anorexia nervosa10.0SLC6A4, POMC
39neuroblastoma10.0DBH, OPRM1
40obsessive-compulsive personality disorder10.0SLC6A4
41delusional disorder10.0DRD2
42alcoholic psychosis10.0SLC6A4
43essential hypertension10.0DBH
44wilson disease10.0SLC6A3, DRD2
45anxiety disorder10.0SLC6A4
46constipation10.0OPRM1, SLC6A4
47gilles de la tourette syndrome10.0SLC6A3, DRD2
48chronic fatigue syndrome10.0POMC, SLC6A4
49dementia10.0OPRM1, OPRK1, SLC6A3
50hypertension10.0SLC6A4, POMC, DBH

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to cocaine dependence

Clinical Features for Cocaine Dependence

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Drugs & Therapeutics for Cocaine Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cocaine Dependence

Drug clinical trials:

Search ClinicalTrials for Cocaine Dependence

Search NIH Clinical Center for Cocaine Dependence

Search CenterWatch for Cocaine Dependence

Genetic Tests for Cocaine Dependence

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Anatomical Context for Cocaine Dependence

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32MalaCards
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MalaCards organs/tissues related to Cocaine Dependence:

32
Brain, Heart, Pituitary, Testes, Cortex, Prostate, Monocytes, Temporal lobe, Subthalamic nucleus

Animal Models for Cocaine Dependence or affiliated genes

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36MGI
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Publications for Cocaine Dependence

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50PubMed
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Articles related to Cocaine Dependence:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Heightened D3 Dopamine Receptor Levels in Cocaine Dependence and Contributions to the Addiction Behavioral Phenotype: A Positron Emission Tomography Study with [(11)C]-(+)-PHNO. (23921256)
2014
2
Bupropion as an Add-on Therapy in Depressed Bipolar Disorder Type I Patients With Comorbid Cocaine Dependence. (24434527)
2014
3
Negative urgency, disinhibition and reduced temporal pole gray matter characterize the comorbidity of cocaine dependence and personality disorders. (23466222)
2013
4
A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. (23952889)
2013
5
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (23958962)
2013
6
A systematic assessment of delay discounting in relation to cocaine and nicotine dependence. (23872502)
2013
7
Enhanced continuing care provided in parallel to intensive outpatient treatment does not improve outcomes for patients with cocaine dependence. (23739030)
2013
8
The effectiveness of treatments for cocaine dependence in schizophrenic patients: a systematic review. (24403872)
2013
9
Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis. (24339190)
2013
10
Association study of the I^-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. (22472784)
2012
11
Associations between behavioral disinhibition and cocaine use history in individuals with cocaine dependence. (22710029)
2012
12
Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. (22327234)
2012
13
Employment-based abstinence reinforcement as a maintenance intervention for the treatment of cocaine dependence: post-intervention outcomes. (21226886)
2011
14
Exploring associations between borderline personality disorder, crack/cocaine dependence, gender, and risky sexual behavior among substance-dependent inpatients. (22448767)
2011
15
Treatment of co-morbid cocaine dependence in schizophrenia with topiramate. (19854620)
2010
16
Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. (19805702)
2009
17
Employment-based abstinence reinforcement as a maintenance intervention for the treatment of cocaine dependence: a randomized controlled trial. (19686522)
2009
18
New medications for the treatment of cocaine dependence. (19636162)
2009
19
Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence. (17574796)
2008
20
Early life trauma and sensitivity to current life stressors in individuals with and without cocaine dependence. (18584568)
2008
21
Attentional bias towards cocaine-related stimuli: relationship to treatment-seeking for cocaine dependence. (17891665)
2007
22
Cocaine craving as a predictor of treatment attrition and outcomes after residential treatment for cocaine dependence. (17690796)
2007
23
Daily stressor sensitivity, abuse effects, and cocaine use in cocaine dependence. (17706887)
2007
24
Outcome predictors in cocaine dependence treatment trials. (17182445)
2006
25
Glucocorticoid negative feedback in methadone-maintained former heroin addicts with ongoing cocaine dependence: dose-response to dexamethasone suppression. (16759341)
2006
26
Aripiprazole in schizophrenia with cocaine dependence: a pilot study. (16012280)
2005
27
Use of dopamine agonist pergolide in outpatient treatment of cocaine dependence. (16040376)
2005
28
A controlled trial of amlodipine for cocaine dependence: a negative report. (15780550)
2005
29
A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence. (15730350)
2005
30
Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers. (12590403)
2003
31
Cocaine withdrawal severity and urine toxicology results from treatment entry predict outcome in medication trials for cocaine dependence. (11817766)
2002
32
Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. (12022962)
2002
33
Determining a diagnostic cut-off on the Severity of Dependence Scale (SDS) for cocaine dependence. (12084142)
2002
34
Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependence. (11853133)
2002
35
Temporal progression of cocaine dependence symptoms in the US National Comorbidity Survey. (12033655)
2002
36
Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. (11173167)
2001
37
Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context. (11403691)
2001
38
Choreoathetoid movements in cocaine dependence. (10376125)
1999
39
Antisocial personality disorder and psychopathy in cocaine-dependent women. (10360122)
1999
40
Increasing treatment adherence among outpatients with depression and cocaine dependence: results of a pilot study. (9812129)
1998
41
The role of multifamily therapy in promoting retention in treatment of alcohol and cocaine dependence. (9522008)
1998
42
A randomized controlled study of the effectiveness of intensive outpatient treatment for cocaine dependence. (9634157)
1998
43
Subclinical neurological and neurovascular deficits in cocaine dependence. Gender and psychosocial considerations. (9369998)
1997
44
Cocaine dependence. A clinical syndrome requiring neuroprotection. (9369997)
1997
45
Incentives improve outcome in outpatient behavioral treatment of cocaine dependence. (8031230)
1994
46
Risk of cocaine abuse and dependence. (1944501)
1991
47
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. (1862788)
1991
48
The cocaine epidemic: treatment options for cocaine dependence. (2204847)
1990
49
Clinical trail of multiple treatment agents for cocaine dependence: a placebo-control; elimination study. (1876104)
1990
50
Functional analysis of lymphocytes subpopulations in experimental cocaine abuse. I. Dose-dependent activation of lymphocyte subsets. (2528433)
1989

Genetic Variations for Cocaine Dependence

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Expression for genes affiliated with Cocaine Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for genes affiliated with Cocaine Dependence

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD3, DRD2
210.2DBH, SLC6A3, SLC6A4
3
Hide members
10.2DRD2, DRD3, SLC18A2
410.2PER1, PDYN, CARTPT
5
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10.1CPLX4, SLC18A2, SLC6A4
610.1SLC18A2, SLC6A3, DRD2, PDYN
7
Hide members
10.1PDYN, DRD2, SLC6A3, SLC18A2
8
Hide members
10.1DRD2, DRD3, SLC6A4, SLC18A2
9
Hide members
10.1NPY1R, NPY2R, DBH, SLC18A2
10
Hide members
10.0OPRM1, OPRK1, NPY5R, NPY2R, NPY1R
11
Hide members
9.7PDYN, NPY1R, NPY2R, NPY5R, DRD2, DRD3
12
Hide members
9.6PER1, CALY, DRD2, DRD3, GABRA2, OPRM1
13
Hide members
9.5PDYN, NPY1R, NPY2R, NPY5R, DRD2, DRD3

Compounds for genes affiliated with Cocaine Dependence

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Cocaine Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 253)
idCompoundScoreTop Affiliating Genes
1u5048844 2811.5PDYN, OPRM1, OPRK1
2nmda44 2811.5OPRK1, OPRM1, SLC6A3, PDYN
3sulpiride44 28 1112.5PDYN, DRD3, DRD2, SLC6A3
4piperazine44 1111.5OPRM1, DRD2, DRD3, SLC6A3
5duloxetine44 49 28 1113.5SLC6A3, SLC6A4, SLC18A2, DRD3
6etorphine44 28 1112.5OPRK1, OPRM1, POMC, PDYN
72beta-carbomethoxy-3beta-(4-iodophenyl)tropane4410.5SLC6A3, SLC6A4, SLC18A2
8methylphenidate44 49 1112.5DRD2, SLC6A4, SLC18A2, SLC6A3
9maoa4410.5DBH, SLC6A4, SLC6A3, POMC, DRD2
10[leu31,pro34]pyy (human)2810.5NPY5R, NPY2R, NPY1R
11[ala31,aib32]npy (pig)2810.4NPY1R, NPY5R, NPY2R
12quinpirole44 2811.4DRD2, PDYN, SLC6A3, DRD3
13risperidone28 44 49 59 11 2415.4SLC6A3, ANKK1, DRD3, DRD2, SLC6A4
14tropane4410.4SLC18A2, SLC6A3, SLC6A4
15ketamine44 28 1112.4OPRM1, DRD2, SLC18A2, SLC6A3, SLC6A4
166-hydroxydopamine4410.4DBH, SLC6A3, OPRM1, PDYN, DRD2, DRD3
17pramipexole44 49 28 1113.4DRD3, SLC6A3, SLC18A2, DRD2
18nisoxetine44 2811.4SLC18A2, SLC6A4, SLC6A3
19clonidine44 28 1112.4POMC, OPRM1, OPRK1, SLC6A4, DBH
20methadone44 49 1112.4POMC, ANKK1, OPRM1, OPRK1, DRD2, PDYN
21gbr 129094410.4SLC18A2, SLC6A3, SLC6A4
22tyramine44 28 2412.4DBH, SLC6A3, SLC6A4, OPRM1
23imipramine44 49 28 11 2414.4DRD3, SLC18A2, SLC6A4, SLC6A3, DBH
24mptp4410.4DBH, DRD3, DRD2, SLC6A4, SLC6A3, SLC18A2
25bupropion44 49 11 2413.4ANKK1, SLC18A2, SLC6A4, DRD2, SLC6A3, DRD3
26methamphetamine44 49 1112.3SLC6A4, SLC18A2, OPRM1, SLC6A3, DRD3, DRD2
27haloperidol44 28 2 49 1114.3SLC6A3, DRD3, OPRM1, POMC, SLC18A2, SLC6A4
28morphine44 49 28 1113.3DRD2, PDYN, NPY5R, OPRK1, OPRM1, DBH
29bibp 3226 trifluoroacetate5910.3NPY1R, NPY2R, NPY5R
30heroin44 49 1112.3PDYN, DRD2, DRD3, OPRK1, OPRM1, POMC
315-hydroxytryptamine4410.2SLC6A3, DRD2, OPRM1, DBH, POMC, SLC18A2
32epinephrine44 11 2412.2DRD2, OPRM1, POMC, PDYN, DBH, SLC6A4
33levodopa44 1111.2SLC6A3, SLC18A2, DBH, PDYN, OPRK1, OPRM1
34dermorphin4410.2PDYN, OPRM1, OPRK1
35amphetamine44 1111.2DRD2, CARTPT, PDYN, OPRK1, POMC, SLC6A3
36bibo 3304 trifluoroacetate5910.2NPY5R, NPY2R, NPY1R
37lobeline4410.2SLC18A2, SLC6A4, SLC6A3
38clozapine44 28 49 1113.2SLC6A3, DRD3, OPRK1, ANKK1, POMC, SLC6A4
39amine4410.2SLC18A2, DRD3, SLC6A4, DBH, OPRK1
40opiate4410.2PDYN, DRD2, OPRK1, OPRM1, POMC, DBH
41ethanol44 49 11 2413.1NPY5R, DBH, PDYN, SLC18A2, ANKK1, OPRK1
42gaba4410.1DRD2, OPRK1, OPRM1, POMC, DBH, SLC6A3
43acetylcholine44 49 28 11 2414.1NPY5R, DRD2, POMC, OPRM1, OPRK1, DBH
44biie 02465910.1NPY1R, NPY5R, NPY2R
45nicotine44 49 28 1113.0PDYN, DRD2, SLC18A2, SLC6A3, DBH, OPRK1
46glutamate4410.0SLC18A2, OPRK1, OPRM1, DBH, PDYN, DRD2
47cocaine44 1111.0SLC6A3, PDYN, DRD2, DRD3, OPRK1, OPRM1
48norepinephrine44 11 2412.0DBH, POMC, OPRM1, OPRK1, DRD3, DRD2
49alpha-methyl-p-tyrosine449.9DRD2, DBH, SLC6A3
50dopamine44 28 11 2412.8SLC18A2, CALY, CARTPT, PDYN, SLC6A4, SLC6A3

GO Terms for genes affiliated with Cocaine Dependence

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16Gene Ontology
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Cellular components related to Cocaine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2integral to plasma membraneGO:0058879.3SLC18A2, CALY, NPY1R, NPY2R, NPY5R, DRD2
3plasma membraneGO:0058869.0DRD2, NPY5R, NPY2R, NPY1R, PDYN, DRD3

Biological processes related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
2response to histamineGO:03477610.7DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
4dopamine catabolic processGO:04242010.7SLC6A3, DBH
5regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3
7adenohypophysis developmentGO:02198410.6SLC6A3, DRD2
8prepulse inhibitionGO:06013410.6DRD2, DRD3, SLC6A3
9reduction of cytosolic calcium ion concentrationGO:05148110.6OPRM1, DRD2
10dopamine metabolic processGO:04241710.6DRD2, DRD3
11behavioral response to ethanolGO:04814910.6DBH, OPRM1, DRD2
12negative regulation of adenylate cyclase activityGO:00719410.6OPRM1, DRD3, DRD2
13regulation of dopamine secretionGO:01405910.6DRD2, DRD3
14visual learningGO:00854210.6DRD2, DRD3, DBH
15monoamine transportGO:01584410.6SLC18A2, SLC6A4, SLC6A3
16sensory perceptionGO:00760010.6OPRK1, OPRM1
17negative regulation of protein secretionGO:05070910.6DRD2, DRD3
18adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.6DRD3, OPRM1
19cardiac left ventricle morphogenesisGO:00321410.6NPY2R, NPY5R
20behavioral response to cocaineGO:04814810.5DRD2, DRD3
21response to cocaineGO:04222010.5SLC18A2, SLC6A3, DRD3, DRD2
22sensory perception of painGO:01923310.5NPY1R, OPRK1, OPRM1
23response to amphetamineGO:00197510.5DRD2, DRD3, DBH, SLC18A2
24circadian regulation of gene expressionGO:03292210.5CARTPT, DRD2, DRD3, PER1
25outflow tract morphogenesisGO:00315110.5NPY1R, NPY2R, NPY5R
26response to iron ionGO:01003910.5DRD2, SLC6A3
27G-protein coupled receptor internalizationGO:00203110.5DRD2, DRD3
28adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.5NPY1R, NPY2R, OPRK1, OPRM1
29synaptic transmission, dopaminergicGO:00196310.5DRD2, DRD3
30response to light stimulusGO:00941610.4PER1, DRD2
31response to drugGO:04249310.3DRD2, DRD3, SLC6A3, SLC6A4
32positive regulation of renal sodium excretionGO:03581510.2DRD3, DRD2
33synaptic transmissionGO:00726810.2CARTPT, PDYN, GABRA2, OPRK1, DBH, SLC6A3
34neuropeptide signaling pathwayGO:00721810.2CARTPT, PDYN, POMC
35neurotransmitter transportGO:00683610.2CPLX4, GABRA2
36locomotory behaviorGO:00762610.1SLC18A2, NPY1R, NPY2R, DRD2, DRD3, OPRK1
37arachidonic acid secretionGO:05048210.0DRD3, DRD2

Molecular functions related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.3SLC6A3, SLC6A4, SLC18A2
2peptide YY receptor activityGO:00160110.3NPY5R, NPY2R, NPY1R
3dopamine bindingGO:03524010.3DRD2, DRD3, SLC6A3
4neuropeptide Y receptor activityGO:00498310.3NPY5R, NPY2R, NPY1R
5pancreatic polypeptide receptor activityGO:00160210.3NPY5R, NPY1R
6serotonin transmembrane transporter activityGO:01522210.2SLC6A4, SLC18A2
7drug bindingGO:00814410.1SLC18A2, SLC6A3, DRD3, DRD2
8dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD3, DRD2

Products for genes affiliated with Cocaine Dependence

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Sources for Cocaine Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet