Aliases & Classifications for Cocaine Dependence

About this section
Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 27ICD9CM
See all sources

Cocaine Dependence, Aliases & Descriptions:

Name: Cocaine Dependence 9 11 43 60


External Ids:

Disease Ontology9 DOID:9975
MeSH33 D019970
NCIt38 C34492
ICD9CM27 304.2, 304.20

Summaries for Cocaine Dependence

About this section


Wikipedia:63 Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine overdose... more...

MalaCards based summary: Cocaine Dependence is related to schizophrenia and antisocial personality disorder. An important gene associated with Cocaine Dependence is PDYN (prodynorphin), and among its related pathways are Monoamine GPCRs and Monoamine Transport. The compounds spiradoline and (-)-n-porphynorapomorphine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related mouse phenotypes are taste/olfaction and skeleton.

Disease Ontology:9 A drug dependence that is a psychological dependency on the regular use of cocaine.

Related Diseases for Cocaine Dependence

About this section

Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.1DRD3, DRD2
2antisocial personality disorder30.9SLC6A3, DRD2
3personality disorder30.9DRD3, SLC6A3, DRD2
4alcohol dependence30.8DRD2, OPRK1
5heroin dependence30.7DRD2
6attention deficit-hyperactivity disorder30.5SLC6A3, DRD2, DBH
7pathological gambling30.5SLC6A3, DRD3, DRD2
8alcohol abuse30.1DRD3, DRD2, SLC6A3
9cocaine abuse30.0OPRK1, DBH, DRD2, SLC6A3
10substance dependence29.9SLC6A3, DRD3, PDYN, DRD2
11ischemia29.8SLC6A3, OPRK1, PDYN, DRD2
12psychotic disorder29.6DRD3, DBH, PDYN, DRD2, SLC6A3
13drug dependence29.6PDYN, SLC6A3, OPRK1, DRD2, DRD3
14bipolar disorder29.4PDYN, DRD3, DRD2, OPRK1, SLC6A3, SLC18A2
15drug addiction29.0SLC18A2, SLC6A3, OPRK1, DRD2, DRD3, PDYN
16mood disorder28.7POMC, DBH, SLC18A2, SLC6A3, DRD2, DRD3
17blindness10.8
18delusional disorder10.4DRD2
19neuroleptic malignant syndrome10.4DRD2
20torsion dystonia10.4DBH
21oppositional defiant disorder10.4SLC6A3
22cerebritis10.4
23cannabis dependence10.3
24post-traumatic stress disorder10.3
25amnestic disorder10.2PDYN, OPRK1
26cannabis abuse10.2
27striatonigral degeneration10.2DRD2, SLC6A3
28essential tremor10.2SLC6A3, DRD3
29supranuclear palsy, progressive10.1DRD2, SLC6A3
30wilson disease10.1DRD2, SLC6A3
31acromegaly10.1DRD2, POMC
32gilles de la tourette syndrome10.1SLC6A3, DRD2
33prolactinoma10.1DRD2, POMC
34anxiety disorder10.1SLC6A3, DRD2
35pituitary tumors10.1DRD2, POMC
36borderline personality disorder10.0
37alexithymia10.0
38congenital syphilis10.0
39dystonia10.0
40hyperthyroidism10.0
41prostatitis10.0
42syphilis10.0
43nicotine dependence, protection against10.0SLC6A3, DRD2
44hyperprolactinemia10.0DBH, POMC, DRD2
45substance abuse10.0DRD2, DRD3, SLC6A3
46pain agnosia10.0OPRK1, POMC, PDYN
47conduct disorder10.0DRD2, DBH, SLC6A3
48multiple system atrophy10.0SLC6A3, DRD2, DBH
49congestive heart failure10.0DBH, PDYN
50dementia, lewy body10.0SLC18A2, SLC6A3

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to cocaine dependence

Symptoms for Cocaine Dependence

About this section

Drugs & Therapeutics for Cocaine Dependence

About this section

Drug clinical trials:

Search ClinicalTrials for Cocaine Dependence

Search NIH Clinical Center for Cocaine Dependence

Genetic Tests for Cocaine Dependence

About this section

Anatomical Context for Cocaine Dependence

About this section

MalaCards organs/tissues related to Cocaine Dependence:

31
Brain, Heart, Pituitary, Testes, Cortex, Prostate, Monocytes, Temporal lobe, Thalamus

Animal Models for Cocaine Dependence or affiliated genes

About this section

Publications for Cocaine Dependence

About this section

Articles related to Cocaine Dependence:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
The self-medication hypothesis and psychostimulant treatment of cocaine dependence: an update. (25187055)
2014
2
Heightened D3 Dopamine Receptor Levels in Cocaine Dependence and Contributions to the Addiction Behavioral Phenotype: A Positron Emission Tomography Study with [(11)C]-(+)-PHNO. (23921256)
2014
3
The influence of dopamine I^-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. (24809448)
2014
4
Attention deficit hyperactivity disorder in cocaine-dependent adults: a psychiatric comorbidity analysis. (23952892)
2013
5
Individual Differences in Attentional Bias Associated with Cocaine Dependence Are Related to Varying Engagement of Neural Processing Networks. (24196947)
2013
6
Negative urgency, disinhibition and reduced temporal pole gray matter characterize the comorbidity of cocaine dependence and personality disorders. (23466222)
2013
7
Functional brain networks associated with cognitive control, cocaine dependence, and treatment outcome. (22775772)
2013
8
Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes. (24312228)
2013
9
Stochastic dynamic causal modeling of working memory connections in cocaine dependence. (23151990)
2012
10
Association study of the I^-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. (22472784)
2012
11
Dopamine agonists for the treatment of cocaine dependence. (22161376)
2011
12
A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. (21849985)
2011
13
Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. (20170711)
2010
14
White matter integrity is associated with treatment outcome measures in cocaine dependence. (20393459)
2010
15
Review of treatment for cocaine dependence. (20088819)
2010
16
Cocaine dependence and concurrent marijuana use: a comparison of clinical characteristics. (19462304)
2009
17
WITHDRAWN: Carbamazepine for cocaine dependence. (19160205)
2009
18
Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (18828811)
2008
19
Efficacy of central nervous system stimulant treatment for cocaine dependence: a systematic review and meta-analysis of randomized controlled clinical trials. (18031423)
2007
20
Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? (17671965)
2007
21
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. (17403976)
2007
22
A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. (16631323)
2006
23
Assessment of cognitive functioning of methadone-maintenance patients: impact of adult ADHD and current cocaine dependence. (17088222)
2006
24
Changes in tobacco smoking following treatment for cocaine dependence. (16595320)
2006
25
Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. (16759340)
2006
26
Nefazodone in out-patient treatment of inhaled cocaine dependence: a randomized double-blind placebo-controlled trial. (15784063)
2005
27
Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response. (15804873)
2005
28
What aspects of treatment matter to the patient in the treatment of cocaine dependence? (15450650)
2004
29
Recent advances in the pharmacotherapy of cocaine dependence. (15355754)
2004
30
Apathy syndrome in cocaine dependence. (11850056)
2002
31
Cocaine withdrawal severity and urine toxicology results from treatment entry predict outcome in medication trials for cocaine dependence. (11817766)
2002
32
Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. (12022962)
2002
33
Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression. (12167556)
2002
34
Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. (11173167)
2001
35
Anger management group treatment for cocaine dependence: preliminary outcomes. (10852354)
2000
36
Counselor prompts to increase condom taking during treatment for cocaine dependence. (9567735)
1998
37
Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects. (9787120)
1998
38
Increasing treatment adherence among outpatients with depression and cocaine dependence: results of a pilot study. (9812129)
1998
39
Structured interview versus self-report test vantages for the assessment of personality pathology in cocaine dependence. (9203112)
1997
40
Replacement medication for cocaine dependence: methylphenidate. (9408812)
1997
41
Overview of potential treatment medications for cocaine dependence. (9467792)
1997
42
Subclinical neurological and neurovascular deficits in cocaine dependence. Gender and psychosocial considerations. (9369998)
1997
43
Are neuroadaptations in D3 dopamine receptors linked to the development of cocaine dependence? (9154209)
1997
44
Carbamazepine treatment of cocaine dependence: a placebo-controlled trial. (7555620)
1995
45
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. (8082553)
1994
46
Combinations of treatment modalities and therapeutic outcome for cocaine dependence. (8289900)
1993
47
Allelic association of the D2 dopamine receptor gene with cocaine dependence. (8261891)
1993
48
Pharmacological approaches to cocaine dependence. (1498999)
1992
49
Developing and evaluating new treatments for alcoholism and cocaine dependence. (1589603)
1992
50
The prevalence of marijuana (cannabis) use and dependence in cocaine dependence. (2234615)
1990

Variations for Cocaine Dependence

About this section

Expression for genes affiliated with Cocaine Dependence

About this section
Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for genes affiliated with Cocaine Dependence

About this section

Pathways related to Cocaine Dependence according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DRD3, DRD2
2
Show member pathways
Serotonin Transporter Activity36
9.4SLC6A3, DBH
39.2DBH, SLC18A2
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
8.9DRD3, DRD2, SLC18A2
5
Show member pathways
8.6SLC18A2, SLC6A3, DRD2
6
Show member pathways
8.3DRD2, DRD3, PDYN, POMC, OPRK1
7
Show member pathways
8.3DRD2, OPRK1, DRD3, PDYN, POMC
8
Show member pathways
8.3PDYN, SLC18A2, SLC6A3, DRD2
9
Show member pathways
8.3SLC6A3, SLC18A2, DRD2, PDYN
10
Show member pathways
8.2SLC18A2, SLC6A3, DRD2, DRD3

Compounds for genes affiliated with Cocaine Dependence

About this section

Compounds related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1spiradoline439.6PDYN, OPRK1
2(-)-n-porphynorapomorphine289.6DRD2, DRD3
3dopac439.4DBH, DRD3, OPRK1
4[3h]nemonapride289.4DRD3, DRD2
5raclopride43 2810.4SLC6A3, DRD2, DRD3
6etorphine43 28 1211.4POMC, PDYN, OPRK1
7piperazine43 1210.4DRD3, DRD2, SLC6A3
8alpha-methyl-p-tyrosine439.3SLC6A3, DRD2, DBH
9sulpiride43 28 1211.1PDYN, DRD3, DRD2, SLC6A3
10apomorphine28 43 1211.1DRD3, DRD2, SLC6A3
11quinpirole43 2810.1SLC6A3, DRD2, DRD3, PDYN
12methadone49 43 1211.1OPRK1, DRD2, PDYN, POMC
13duloxetine43 49 28 1212.0DRD3, SLC6A3, SLC18A2
14tetrabenazine43 28 59 49 1213.0SLC18A2, SLC6A3, DRD2
15bromocriptine43 28 1210.9POMC, DRD3, DRD2, SLC6A3
16methylphenidate43 49 1210.9SLC18A2, SLC6A3, DRD2
17maoa438.9SLC6A3, DRD2, POMC, DBH
18reserpine43 28 1210.9DRD2, SLC6A3, SLC18A2
19ketamine43 28 1210.8SLC18A2, SLC6A3, DRD2
20acth438.8DBH, POMC, PDYN, OPRK1
21paroxetine43 49 28 1211.8DRD3, SLC6A3, SLC18A2
226-hydroxydopamine438.7SLC6A3, DRD2, DRD3, PDYN, DBH
23pramipexole43 28 49 1211.6SLC18A2, SLC6A3, DRD2, DRD3
24spec-t438.6SLC18A2, SLC6A3, DRD2
25bupropion49 43 24 1211.6DRD3, DRD2, SLC6A3, SLC18A2
26amine438.6DBH, DRD3, OPRK1, SLC18A2
27lead438.6DBH, DRD3, OPRK1, SLC18A2
28imipramine43 28 49 24 1212.5SLC18A2, SLC6A3, DRD3, DBH
29morphine43 49 28 1211.5DBH, PDYN, DRD2, OPRK1, SLC6A3
30clozapine43 28 49 1211.4POMC, DRD3, DRD2, OPRK1, SLC6A3
31catecholamine438.4DBH, POMC, PDYN, DRD3, SLC18A2
32methamphetamine43 49 1210.3PDYN, DRD3, DRD2, SLC6A3, SLC18A2
33epinephrine43 24 1210.3DBH, POMC, PDYN, DRD2, SLC18A2
34mptp438.2DBH, DRD3, DRD2, SLC6A3, SLC18A2
35heroin43 49 1210.1POMC, SLC6A3, OPRK1, DRD2, DRD3, PDYN
36haloperidol43 49 28 2 1212.1POMC, DRD3, DRD2, SLC6A3, SLC18A2
375-hydroxytryptamine438.0DBH, POMC, DRD2, SLC6A3, SLC18A2
38sodium43 248.9DBH, DRD3, OPRK1, SLC6A3, SLC18A2
39nmda43 288.8PDYN, DRD3, DRD2, OPRK1, SLC6A3, SLC18A2
40opiate437.7SLC6A3, OPRK1, DRD2, DRD3, PDYN, POMC
41amphetamine43 49 129.7SLC18A2, SLC6A3, OPRK1, DRD2, PDYN, POMC
42cysteine437.6DBH, PDYN, DRD3, OPRK1, SLC6A3, SLC18A2
43levodopa43 128.4DRD2, DRD3, PDYN, DBH, OPRK1, SLC6A3
44nicotine43 28 49 1210.4DRD3, PDYN, DBH, DRD2, OPRK1, SLC6A3
45glutamate437.3DBH, PDYN, DRD3, DRD2, OPRK1, SLC6A3
46gaba437.2DBH, POMC, PDYN, DRD2, OPRK1, SLC6A3
47acetylcholine43 49 28 24 1211.2DBH, POMC, PDYN, DRD2, OPRK1, SLC6A3
48norepinephrine43 24 128.8SLC18A2, SLC6A3, OPRK1, DRD2, DRD3, PDYN
49cocaine43 127.8SLC18A2, SLC6A3, DBH, POMC, PDYN, DRD3
50dopamine43 28 24 129.8SLC18A2, SLC6A3, OPRK1, DRD2, DRD3, PDYN

GO Terms for genes affiliated with Cocaine Dependence

About this section

Cellular components related to Cocaine Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:00301399.7DRD2, DRD3
2secretory granule lumenGO:00347749.5POMC, DBH
3synaptic vesicle membraneGO:00306728.9SLC18A2, DRD2
4integral component of plasma membraneGO:00058877.8OPRK1, DRD3, DRD2, SLC6A3, SLC18A2
5plasma membraneGO:00058867.3PDYN, SLC6A3, SLC18A2, OPRK1, DRD2, DRD3

Biological processes related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotion involved in locomotory behaviorGO:009032510.1DRD2, DRD3
2response to histamineGO:003477610.1DRD2, DRD3
3negative regulation of dopamine receptor signaling pathwayGO:006016010.1DRD2, DRD3
4regulation of dopamine uptake involved in synaptic transmissionGO:005158410.1DRD3, DRD2
5regulation of cAMP metabolic processGO:003081410.1DRD3, DRD2
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:000719510.1DRD3, DRD2
7dopamine metabolic processGO:004241710.0DRD2, DRD3
8negative regulation of protein secretionGO:005070910.0DRD3, DRD2
9G-protein coupled receptor internalizationGO:000203110.0DRD3, DRD2
10synaptic transmission, dopaminergicGO:000196310.0DRD3, DRD2
11behavioral response to cocaineGO:004814810.0DRD3, DRD2
12arachidonic acid secretionGO:005048210.0DRD3, DRD2
13positive regulation of renal sodium excretionGO:003581510.0DRD3, DRD2
14circadian regulation of gene expressionGO:003292210.0DRD2, DRD3
15behavioral response to ethanolGO:004814910.0DBH, DRD2
16response to morphineGO:00432789.9DRD2, DRD3
17negative regulation of adenylate cyclase activityGO:00071949.9DRD3, DRD2
18negative regulation of protein kinase B signalingGO:00518989.9DRD2, DRD3
19negative regulation of blood pressureGO:00457769.9DRD3, DRD2
20positive regulation of cytokinesisGO:00324679.8DRD2, DRD3
21adenohypophysis developmentGO:00219849.8SLC6A3, DRD2
22dopamine catabolic processGO:00424209.8DBH, SLC6A3
23response to iron ionGO:00100399.7DRD2, SLC6A3
24response to nicotineGO:00350949.7SLC6A3, DRD2
25visual learningGO:00085429.6DBH, DRD3, DRD2
26cellular calcium ion homeostasisGO:00068749.6DRD2, DRD3
27positive regulation of multicellular organism growthGO:00400189.6SLC6A3, DRD2
28response to ethanolGO:00454719.5SLC6A3, DRD3
29prepulse inhibitionGO:00601349.5SLC6A3, DRD2, DRD3
30sensory perception of smellGO:00076089.4SLC6A3, DRD2
31monoamine transportGO:00158449.4SLC18A2, SLC6A3
32response to drugGO:00424939.1DRD3, DRD2, SLC6A3
33glucose homeostasisGO:00425938.9SLC18A2, DBH
34response to amphetamineGO:00019758.8DBH, DRD3, DRD2, SLC18A2
35response to cocaineGO:00422208.7DRD3, DRD2, SLC6A3, SLC18A2
36synaptic transmissionGO:00072688.5DBH, OPRK1, SLC6A3, SLC18A2
37locomotory behaviorGO:00076267.7SLC18A2, SLC6A3, OPRK1, DRD2, DRD3, DBH

Molecular functions related to Cocaine Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.4DRD3, DRD2
2monoamine transmembrane transporter activityGO:00085049.0SLC18A2, SLC6A3
3dopamine bindingGO:00352409.0DRD2, SLC6A3, DRD3
4drug bindingGO:00081448.2DRD3, SLC18A2, SLC6A3, DRD2

Products for genes affiliated with Cocaine Dependence

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Cocaine Dependence

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet