MCID: CCN001
MIFTS: 56

Cocaine Dependence malady

Summaries for Cocaine Dependence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine overdose... more...

MalaCards: Cocaine Dependence is related to alcohol dependence and drug dependence. An important gene associated with Cocaine Dependence is PDYN (prodynorphin), and among its related pathways are Dopamine receptors and Monoamine Transport. The compounds u50488 and nmda have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related mouse phenotypes are taste/olfaction and adipose tissue.

Disease Ontology:8 A drug dependence that is a psychological dependency on the regular use of cocaine.

Aliases & Classifications for Cocaine Dependence

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

cocaine dependence 8 10 44 60


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Disease Ontology8 DOID:9975
ICD9CM27 304.20, 304.2
NCIt39 C34492
MeSH34 D019970

Related Diseases for Cocaine Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.0DRD2, GABRA2, SLC6A4, ANKK1, OPRM1, OPRK1
2drug dependence31.0OPRK1, OPRM1, SLC6A3, SLC6A4, PDYN, DRD2
3heroin dependence30.8DRD2, ANKK1
4personality disorder30.8DRD2, SLC6A4, DRD3, SLC6A3
5cocaine abuse30.8DRD2, OPRK1, DBH, SLC6A3, SLC6A4
6antisocial personality disorder30.6ANKK1, SLC6A3, SLC6A4, DRD2
7schizophrenia30.6CALY, PDYN, DBH, SLC6A3, SLC6A4, DRD2
8bipolar disorder30.6DRD2, SLC6A4
9opiate dependence30.6OPRM1
10substance dependence30.5OPRM1, SLC6A3, SLC6A4, DRD2, PDYN, DRD3
11nicotine dependence30.4SLC6A4, ANKK1, DRD2
12attention deficit hyperactivity disorder30.3DRD2, DBH, SLC6A4, SLC6A3, SLC18A2
13alexithymia30.0ANKK1
14pathological gambling30.0DRD3, DRD2, SLC6A3
15schizoaffective disorder30.0SLC6A4, DRD2, DRD3
16ischemia30.0DRD2, PDYN, SLC6A3, OPRK1
17alcohol abuse30.0SLC6A3, OPRM1, DRD3, DRD2, SLC6A4
18mood disorder30.0DBH, DRD3, POMC, SLC18A2, SLC6A3, SLC6A4
19dependent personality disorder10.6
20cannabis dependence10.5
21cerebritis10.3
22post-traumatic stress disorder10.2
23major depressive disorder10.0
24borderline personality disorder10.0
25cannabis abuse10.0
26bipolar i disorder10.0
27congenital syphilis10.0
28hyperthyroidism10.0
29prostatitis10.0
30sexual disorder10.0
31syphilis10.0
32restless legs syndrome10.0DRD2
33bulimia nervosa10.0SLC6A4
34eating disorder10.0SLC6A4
35prion disease10.0POMC
36neuroleptic malignant syndrome10.0DRD2
37fibromyalgia10.0SLC6A4
38anorexia nervosa10.0SLC6A4, POMC
39neuroblastoma10.0DBH, OPRM1
40obsessive-compulsive personality disorder10.0SLC6A4
41delusional disorder10.0DRD2
42alcoholic psychosis10.0SLC6A4
43essential hypertension10.0DBH
44wilson disease10.0SLC6A3, DRD2
45anxiety disorder10.0SLC6A4
46constipation10.0OPRM1, SLC6A4
47gilles de la tourette syndrome10.0SLC6A3, DRD2
48chronic fatigue syndrome10.0POMC, SLC6A4
49dementia10.0OPRM1, OPRK1, SLC6A3
50hypertension10.0SLC6A4, POMC, DBH

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to cocaine dependence

Clinical Features for Cocaine Dependence

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Drugs & Therapeutics for Cocaine Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cocaine Dependence

Drug clinical trials:

Search ClinicalTrials for Cocaine Dependence

Search NIH Clinical Center for Cocaine Dependence

Search CenterWatch for Cocaine Dependence

Genetic Tests for Cocaine Dependence

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Anatomical Context for Cocaine Dependence

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32MalaCards
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MalaCards organs/tissues related to Cocaine Dependence:

32
Brain, Heart, Pituitary, Testes, Cortex, Prostate, Monocytes, Temporal lobe, Subthalamic nucleus

Animal Models for Cocaine Dependence or affiliated genes

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36MGI
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Publications for Cocaine Dependence

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50PubMed
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Articles related to Cocaine Dependence:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Functional brain networks associated with cognitive control, cocaine dependence, and treatment outcome. (22775772)
2013
2
A systematic review comparing cognitive-behavioral therapy and contingency management for cocaine dependence. (24074193)
2013
3
Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. (23485852)
2013
4
A comparison of trauma profiles among individuals with prescription opioid, nicotine, or cocaine dependence. (23414497)
2013
5
Impulsivity in adult ADHD patients with and without cocaine dependence. (23026814)
2013
6
The Sexual Discounting Task: HIV risk behavior and the discounting of delayed sexual rewards in cocaine dependence. (22055012)
2012
7
Combination of Modafinil and d-amphetamine for the Treatment of Cocaine Dependence: A Preliminary Investigation. (22969732)
2012
8
Dopamine agonists for the treatment of cocaine dependence. (22161376)
2011
9
A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. (21849985)
2011
10
Diagnosing adult attention deficit/hyperactivity disorder in patients with cocaine dependence: discriminant validity of Barkley executive dysfunction symptoms. (21912132)
2011
11
Disulfiram for the treatment of cocaine dependence. (20091613)
2010
12
Anticonvulsant drugs in cocaine dependence: a systematic review and meta-analysis. (19717271)
2010
13
Written emotional expression during recovery from cocaine dependence: group and individual differences in craving intensity. (20441458)
2010
14
Cocaine dependence and concurrent marijuana use: a comparison of clinical characteristics. (19462304)
2009
15
A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. (18923396)
2009
16
Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels. (19046384)
2008
17
The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (18422838)
2008
18
A double-blind, placebo-controlled trial of reserpine for the treatment of cocaine dependence. (17628352)
2007
19
Early abstinence in cocaine dependence: influence of comorbid major depression. (17661196)
2007
20
A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. (16631323)
2006
21
Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population. (16461866)
2006
22
A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. (16272961)
2005
23
CALCYON gene variation, schizophrenia, and cocaine dependence. (14755439)
2004
24
Treatment responsivity of cocaine-dependent patients with antisocial personality disorder to cognitive-behavioral and contingency management interventions. (12699026)
2003
25
Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells. (11948252)
2002
26
From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. (11927172)
2002
27
Review: dopamine agonists are not effective for cocaine dependence. (12180450)
2002
28
Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence. (12233989)
2002
29
A randomized controlled trial of auricular acupuncture for cocaine dependence: treatments vs outcomes. (11268238)
2001
30
Cocaine dependence: a disease of the brain's reward centers. (11728784)
2001
31
Antidepressants for cocaine dependence. (11687168)
2001
32
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. (10823899)
2000
33
Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. (10633042)
2000
34
Racial identity and its assessment in a sample of African-American men in treatment for cocaine dependence. (10718166)
2000
35
A randomized controlled trial of auricular acupuncture for cocaine dependence. (10927727)
2000
36
A two-rate hypothesis for patterns of retention in psychosocial treatments of cocaine dependence: findings from a study of African-American men and a review of the published data. (10598215)
1999
37
Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects. (9787120)
1998
38
Pharmacotherapy of cerebral ischemia in cocaine dependence. (9543650)
1998
39
The Addiction Severity Index in clinical efficacy trials of medications for cocaine dependence. (9467798)
1997
40
Medication Development for the Treatment of Cocaine Dependence: Issues in Clinical Efficacy Trials. October 20-21, 1994. (9508643)
1997
41
Integrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial. (8742770)
1995
42
Fluoxetine for cocaine dependence in methadone maintenance. (7806696)
1994
43
Dissociation of "conscious desire" (craving) from and relapse in alcohol and cocaine dependence. (7804394)
1994
44
Allelic association of the D2 dopamine receptor gene with cocaine dependence. (8261891)
1993
45
Clinical freedom and drug dependence. No rationale for prescribing cocaine to addicts. (8123150)
1993
46
Use of a cue exposure paradigm for the evaluation of a potential pharmacotherapeutic agents for cocaine dependence. (8178699)
1993
47
Drugs for cocaine dependence: not easy. (1444730)
1992
48
Psychotherapy for cocaine dependence. (1638915)
1992
49
Day hospital versus inpatient cocaine dependence rehabilitation: an interim report. (1876041)
1990
50
Cocaine and heroin dependence compared in poly-drug abusers. (3354742)
1988

Genetic Variations for Cocaine Dependence

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Expression for genes affiliated with Cocaine Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for genes affiliated with Cocaine Dependence

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD3, DRD2
210.2DBH, SLC6A3, SLC6A4
3
Hide members
10.2DRD2, DRD3, SLC18A2
410.2PER1, PDYN, CARTPT
5
Hide members
10.1CPLX4, SLC18A2, SLC6A4
610.1SLC18A2, SLC6A3, DRD2, PDYN
7
Hide members
10.1PDYN, DRD2, SLC6A3, SLC18A2
8
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10.1DRD2, DRD3, SLC6A4, SLC18A2
9
Hide members
10.1NPY1R, NPY2R, DBH, SLC18A2
10
Hide members
10.0OPRM1, OPRK1, NPY5R, NPY2R, NPY1R
11
Hide members
9.7PDYN, NPY1R, NPY2R, NPY5R, DRD2, DRD3
12
Hide members
9.6PER1, CALY, DRD2, DRD3, GABRA2, OPRM1
13
Hide members
9.5PDYN, NPY1R, NPY2R, NPY5R, DRD2, DRD3

Compounds for genes affiliated with Cocaine Dependence

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Cocaine Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 253)
idCompoundScoreTop Affiliating Genes
1u5048844 2811.5OPRM1, OPRK1, PDYN
2nmda44 2811.5PDYN, OPRK1, SLC6A3, OPRM1
3piperazine44 1111.5DRD3, OPRM1, SLC6A3, DRD2
4sulpiride44 28 1112.5SLC6A3, DRD3, DRD2, PDYN
5duloxetine44 49 28 1113.5SLC18A2, SLC6A4, SLC6A3, DRD3
6etorphine44 28 1112.5PDYN, OPRK1, POMC, OPRM1
72beta-carbomethoxy-3beta-(4-iodophenyl)tropane4410.5SLC18A2, SLC6A4, SLC6A3
8methylphenidate44 49 1112.5SLC6A3, SLC18A2, DRD2, SLC6A4
9maoa4410.5DBH, SLC6A4, SLC6A3, POMC, DRD2
10[ala31,aib32]npy (pig)2810.5NPY2R, NPY5R, NPY1R
11[leu31,pro34]pyy (human)2810.4NPY5R, NPY2R, NPY1R
12quinpirole44 2811.4PDYN, DRD3, SLC6A3, DRD2
13risperidone28 44 49 59 11 2415.4SLC6A4, SLC6A3, ANKK1, DRD3, DRD2
14gbr 129094410.4SLC6A3, SLC6A4, SLC18A2
15ketamine44 28 1112.4SLC6A4, SLC18A2, SLC6A3, OPRM1, DRD2
166-hydroxydopamine4410.4DRD2, SLC6A3, DBH, OPRM1, DRD3, PDYN
17pramipexole44 49 28 1113.4DRD2, DRD3, SLC18A2, SLC6A3
18nisoxetine44 2811.4SLC18A2, SLC6A4, SLC6A3
19clonidine44 28 1112.4DBH, SLC6A4, POMC, OPRM1, OPRK1
20methadone44 49 1112.4POMC, ANKK1, OPRM1, OPRK1, DRD2, PDYN
21tropane4410.4SLC6A3, SLC6A4, SLC18A2
22tyramine44 28 2412.4DBH, OPRM1, SLC6A3, SLC6A4
23imipramine44 49 28 11 2414.4DBH, SLC6A3, SLC6A4, SLC18A2, DRD3
24mptp4410.4SLC18A2, SLC6A4, SLC6A3, DBH, DRD3, DRD2
25bupropion44 49 11 2413.4ANKK1, SLC18A2, SLC6A4, DRD2, SLC6A3, DRD3
26methamphetamine44 49 1112.3SLC6A4, SLC18A2, OPRM1, SLC6A3, DRD3, DRD2
27haloperidol44 28 2 49 1114.3SLC6A3, DRD3, OPRM1, POMC, SLC18A2, SLC6A4
28morphine44 49 28 1113.3DRD2, DBH, SLC6A3, OPRK1, NPY5R, PDYN
29[leu31,pro34]-neuropeptide y (human, rat)5910.3NPY1R, NPY2R, NPY5R
30heroin44 49 1112.3PDYN, DRD2, DRD3, OPRK1, OPRM1, POMC
315-hydroxytryptamine4410.2SLC18A2, SLC6A4, DRD2, OPRM1, POMC, DBH
32epinephrine44 11 2412.2DRD2, PDYN, SLC18A2, SLC6A4, DBH, POMC
33levodopa44 1111.2SLC6A3, SLC18A2, DBH, PDYN, OPRK1, OPRM1
34amphetamine44 1111.2DRD2, CARTPT, PDYN, OPRK1, POMC, SLC6A3
35bibp 3226 trifluoroacetate5910.2NPY5R, NPY2R, NPY1R
36clozapine44 28 49 1113.2SLC6A3, DRD3, OPRK1, ANKK1, POMC, SLC6A4
37amine4410.2OPRK1, DBH, SLC6A4, DRD3, SLC18A2
38opiate4410.2PDYN, DRD2, OPRK1, OPRM1, POMC, DBH
39neuropeptide y (human, rat)5910.2NPY1R, NPY5R, NPY2R
40biie 02465910.2NPY5R, NPY2R, NPY1R
41ethanol44 49 11 2413.1PDYN, NPY5R, OPRK1, SLC18A2, OPRM1, ANKK1
42alpha-methyl-p-tyrosine4410.1DRD2, SLC6A3, DBH
43gaba4410.1DRD2, OPRK1, OPRM1, POMC, DBH, SLC6A3
44acetylcholine44 49 28 11 2414.1NPY5R, DRD2, POMC, OPRM1, OPRK1, DBH
45nicotine44 49 28 1113.0PDYN, DRD2, SLC18A2, SLC6A3, DBH, OPRK1
46glutamate4410.0OPRM1, DBH, SLC6A3, SLC18A2, OPRK1, PDYN
47cocaine44 1111.0SLC6A3, PDYN, DRD2, DRD3, OPRK1, OPRM1
48norepinephrine44 11 2412.0DBH, POMC, OPRM1, OPRK1, DRD3, DRD2
49nalmefene44 2810.9OPRK1, PDYN, OPRM1
50dopamine44 28 11 2412.8SLC18A2, CALY, CARTPT, PDYN, SLC6A4, SLC6A3

GO Terms for genes affiliated with Cocaine Dependence

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16Gene Ontology
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Cellular components related to Cocaine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2integral to plasma membraneGO:0058879.3SLC18A2, CALY, NPY1R, NPY2R, NPY5R, DRD2
3plasma membraneGO:0058869.0DRD2, NPY5R, NPY2R, NPY1R, PDYN, DRD3

Biological processes related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
2response to histamineGO:03477610.7DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
4dopamine catabolic processGO:04242010.7SLC6A3, DBH
5regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3
7adenohypophysis developmentGO:02198410.6SLC6A3, DRD2
8prepulse inhibitionGO:06013410.6DRD2, DRD3, SLC6A3
9reduction of cytosolic calcium ion concentrationGO:05148110.6OPRM1, DRD2
10dopamine metabolic processGO:04241710.6DRD2, DRD3
11behavioral response to ethanolGO:04814910.6DBH, OPRM1, DRD2
12negative regulation of adenylate cyclase activityGO:00719410.6OPRM1, DRD3, DRD2
13regulation of dopamine secretionGO:01405910.6DRD2, DRD3
14visual learningGO:00854210.6DRD2, DRD3, DBH
15monoamine transportGO:01584410.6SLC18A2, SLC6A4, SLC6A3
16sensory perceptionGO:00760010.6OPRK1, OPRM1
17negative regulation of protein secretionGO:05070910.6DRD2, DRD3
18adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.6DRD3, OPRM1
19cardiac left ventricle morphogenesisGO:00321410.6NPY2R, NPY5R
20behavioral response to cocaineGO:04814810.5DRD2, DRD3
21response to cocaineGO:04222010.5SLC18A2, SLC6A3, DRD3, DRD2
22sensory perception of painGO:01923310.5NPY1R, OPRK1, OPRM1
23response to amphetamineGO:00197510.5DRD2, DRD3, DBH, SLC18A2
24circadian regulation of gene expressionGO:03292210.5CARTPT, DRD2, DRD3, PER1
25outflow tract morphogenesisGO:00315110.5NPY1R, NPY2R, NPY5R
26response to iron ionGO:01003910.5DRD2, SLC6A3
27G-protein coupled receptor internalizationGO:00203110.5DRD2, DRD3
28adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.5NPY1R, NPY2R, OPRK1, OPRM1
29synaptic transmission, dopaminergicGO:00196310.5DRD2, DRD3
30response to light stimulusGO:00941610.4PER1, DRD2
31response to drugGO:04249310.3DRD2, DRD3, SLC6A3, SLC6A4
32positive regulation of renal sodium excretionGO:03581510.2DRD3, DRD2
33synaptic transmissionGO:00726810.2CARTPT, PDYN, GABRA2, OPRK1, DBH, SLC6A3
34neuropeptide signaling pathwayGO:00721810.2CARTPT, PDYN, POMC
35neurotransmitter transportGO:00683610.2CPLX4, GABRA2
36locomotory behaviorGO:00762610.1SLC18A2, NPY1R, NPY2R, DRD2, DRD3, OPRK1
37arachidonic acid secretionGO:05048210.0DRD3, DRD2

Molecular functions related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.3SLC6A3, SLC6A4, SLC18A2
2peptide YY receptor activityGO:00160110.3NPY5R, NPY2R, NPY1R
3dopamine bindingGO:03524010.3DRD2, DRD3, SLC6A3
4neuropeptide Y receptor activityGO:00498310.3NPY5R, NPY2R, NPY1R
5pancreatic polypeptide receptor activityGO:00160210.3NPY5R, NPY1R
6serotonin transmembrane transporter activityGO:01522210.2SLC6A4, SLC18A2
7drug bindingGO:00814410.1SLC18A2, SLC6A3, DRD3, DRD2
8dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD3, DRD2

Products for genes affiliated with Cocaine Dependence

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Sources for Cocaine Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet