Cocaine Dependence malady

Wikipedia: Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine use can...⁴⁴ more...

MalaCards: Cocaine Dependence is related to schizophrenia and alcoholism. An important gene associated with Cocaine Dependence is DBH (dopamine beta-hydroxylase (dopamine beta-monooxygenase)), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Circadian Clock in Mammals. The compounds nicotine and quinpirole have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and prostate, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology: A drug dependence that is a psychological dependency on the regular use of cocaine.⁶

Aliases & Descriptions:

cocaine dependence 6 8 32 43

Diseases related to cocaine dependence by text searches and GeneDecks gene sharing:

(show top 50)    (show all 208)

id	Related Disease	Score	Top Affiliating Genes
1	schizophrenia	29.1	ANKK1, DRD2, DRD3, COMT
2	alcoholism	26.2	CNR1, MAOB, HTR2C, CARTPT, TPH2, DRD1
3	nicotine dependence	26.2	CNR1, ANKK1, MAOB, CARTPT, TPH2, DRD1
4	adhd	24.1	CNR1, PAWR, ANKK1, MAOB, HTR2C, CALY
5	blindness	24.0	CNR1, MAOB, HTR2C, DRD2, DRD3, CRH
6	prostatitis	22.4	CNR1, CLOCK, PAWR, GSTP1, DRD2, CRH
7	alcohol dependence	20.1	CNR1, ANKK1, MAOB, HTR2C, HOMER1, HOMER2
8	leptin receptor deficiency	13.6	DRD2, SLC6A3
9	attention deficit hyperactivity disorder	13.6	DRD4, SLC6A3
10	separation anxiety disorder	13.6	DRD4, SLC6A3
11	neuroleptic malignant syndrome	13.6	ANKK1, DRD2, POMC
12	striatonigral degeneration	13.6	DRD1, DRD2, SLC6A3
13	myoclonus-dystonia	13.6	DRD2, DRD3, DRD4
14	alcohol withdrawal delirium	13.5	DBH, SLC6A3, GABRA2
15	amnestic disorder	13.5	CNR1, PDYN, POMC
16	movement disease	13.5	DRD2, DRD3, SLC6A3
17	delusional disorder	13.5	DRD3, DRD4
18	alcoholic psychosis	13.5	SLC6A3, SLC6A4
19	conduction disease	13.4	DRD4, DBH, SLC6A3, SLC6A4
20	opiate dependence	13.4	DRD2, DRD3, COMT
21	delayed sleep phase syndrome	13.4	CLOCK, PER2
22	dyslexia	13.4	DRD2, DRD3, DRD4, SLC6A3
23	social phobia	13.4	DRD2, COMT, SLC6A4
24	progressive supranuclear palsy	13.4	DRD2, ACHE, SLC6A3
25	tic disorder	13.4	DRD2, DRD4
26	rem sleep behavior disorder	13.3	ACHE, SLC6A3
27	orthostatic hypotension	13.3	ACHE, DBH, POMC
28	panic disorder	13.3	CRH, POMC, SLC6A4
29	novelty seeking personality	13.3	DRD2, DRD4, COMT
30	lewy body dementia	13.2	MAOB, ACHE, SLC6A3
31	fetal akinesia syndrome x-linked	13.2	MAOB, COMT
32	endogenous depression	13.2	CRH, SLC6A4
33	antisocial personality disorder	13.2	ANKK1, DRD2, DRD4, SLC6A4, GABRA2
34	central nervous system disease	13.2	CNR1, SLC6A3, SLC6A4
35	toxic encephalopathy	13.2	MAOB, PDYN, SLC6A3, SLC6A4
36	phenylketonuria	13.1	MAOB, DRD2, ACHE, SLC6A3
37	neurotic disorder	13.1	DRD2, DRD3, DRD4, COMT, SLC6A4
38	gilles de la tourette syndrome	13.1	DRD2, DRD4, COMT, DBH, SLC6A3
39	cannabis dependence	13.1	CNR1, COMT, GABRA2, CHRNA5
40	chronic pain	13.1	COMT, PDYN, ACHE, DBH
41	advanced sleep phase syndrome	13.0	CLOCK, TPH2, PER1, PER2
42	migraine with aura	13.0	HTR2C, DRD2, DBH, SLC6A3, SLC6A4
43	sudden infant death syndrome	13.0	MAOB, TPH2, SLC6A3, SLC6A4
44	cognitive disease	13.0	MAOB, COMT, ACHE
45	manic-depressive illness	13.0	MAOB, DRD2, DRD3, DRD4, DBH, SLC6A3
46	essential tremor	12.9	GSTP1, DRD3, COMT, SLC6A3
47	myoclonus	12.9	HTR2C, DRD2, DRD3, DRD4, POMC
48	schizophreniform disorder	12.9	DRD2, PRL
49	pathological gambling	12.9	MAOB, DRD1, DRD2, DRD3, DRD4, SLC6A3
50	peripartum cardiomyopathy	12.9	DRD2, PRL

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cocaine dependence:

²²

MGI Mouse Phenotypes related to cocaine dependence:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.7	CNR1, TPH2, DRD2, SLC6A3
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	PER2, NPY2R, OPRK1, DBH, HOMER2, HOMER1
3	skeleton phenotype	MP:0005390	9.3	PER2, NPY2R, NPY1R, PDYN, DRD2, CARTPT
4	renal/urinary system phenotype	MP:0005367	8.6	PER2, PER1, NPY2R, NPY, POMC, COMT
5	digestive/alimentary phenotype	MP:0005381	8.5	PER2, NPY2R, NPY, OPRK1, PDYN, DRD3
6	no phenotypic analysis	MP:0003012	8.1	GABRA2, PER2, NPY1R, POMC, ACHE, DRD2
7	reproductive system phenotype	MP:0005389	7.5	PER2, PER1, SLC6A3, NPY2R, NPY1R, OPRK1
8	adipose tissue phenotype	MP:0005375	6.9	ACHE, POMC, NPY, NPY1R, NPY2R, NPY5R
9	mortality/aging	MP:0010768	6.2	NPY1R, NPY2R, SLC6A3, SLC6A4, PER1, PER2
10	integument phenotype	MP:0010771	6.2	PRL, OPRK1, POMC, NPY1R, SLC6A3, SLC6A4
11	nervous system phenotype	MP:0003631	4.9	SLC6A3, SLC6A4, NPY, POMC, DRD3, DRD4
12	growth/size phenotype	MP:0005378	4.7	DBH, POMC, NPY, NPY1R, NPY2R, NPY5R
13	homeostasis/metabolism phenotype	MP:0005376	3.8	GABRA2, CNR1, CLOCK, MAOB, HTR2C, CARTPT
14	behavior/neurological phenotype	MP:0005386	2.9	CNR1, DRD3, DRD4, CRH, COMT, PDYN

Articles related to cocaine dependence:

(show top 50)    (show all 53)

id	Title	Authors	Year	Affiliating Genes
1	Association study between the DAT1, DBH and DRD2 gene s and cocaine dependence in a Spanish sample. (20505554)	FernA ndez-Castillo N.... Cormand B.	2010	DBH, DRD2, SLC6A3
2	Donepezil treatment and the subjective effects of int ravenous cocaine in dependent individuals. (19836169)	Grasing K.... Desouza C.	2010	ACHE
3	The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. (19833324)	Enoch M.A.... Roy A.	2010	GABRA2
4	Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. (19429035)	Lohoff F.W.... Oslin D.W.	2009	CDNF
5	Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. (19349312)	Brady K.T.... Kreek M.J.	2009	POMC, CRH
6	Discovery of drugs to treat cocaine dependence: behav ioral and neurochemical effects of atypical dopamine transport inhibitors. (20230764)	Tanda G.... Katz J.L.	2009	SLC6A3
7	Association analysis between polymorphisms in the dop amine D3 receptor (DRD3) gene and cocaine dependence. (19503018)	Bloch P.J.... Lohoff F.W.	2009	DRD3
8	Neuropeptide Y Receptor Genes Are Associated With Alcohol Dependence, Alcohol Withdrawal Phenotypes, and Cocaine Dependence. (18828811)	Wetherill L.... Foroud T.	2008	NPY, NPY1R, NPY2R
9	Dopamine transporter levels in cocaine dependent subj ects. (18565692)	Crits-Christoph P.... Present J.	2008	SLC6A3
10	A Functional Haplotype Implicated in Vulnerability to Develop Cocaine Dependence is Associated with Reduced PDYN Expression in Human Brain. (18923396)	Yuferov V.... Kreek M.J.	2008	OPRK1, PDYN
11	A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence. (18519132)	Grucza R.A.... Bierut L.J.	2008	CHRNA5
12	Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. (18572320)	Lohoff F.W.... Berrettini W.H.	2008	CARTPT
13	Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. (18704099)	Lohoff F.W.... Berrettini W.H.	2008	COMT
14	Interaction Between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample. (19052543)	Zuo L.... Gelernter J.	2008	CNR1
15	The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (18422838)	Foroud T.... Edenberg H.J.	2008	TACR3
16	Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. (18321529)	Patkar A.A.... Kuhn C.	2008	PRL, SLC6A4
17	Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? (17671965)	Ballon N.... Poirier M.F.	2007	DRD2, SLC6A3, DRD3
18	Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. (16759340)	Dahl J.P.... Berrettini W.H.	2006	TPH2
19	Relationship of prolactin response to meta-chlorophen ylpiperazine with severity of drug use in cocaine dependence. (16915581)	Patkar A.A.... Lee T.H.	2006	PRL
20	Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence. (16730924)	Elkashef A.... Sather M.	2006	MAOB
21	Relationship of disinhibition and aggression to blunt ed prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patie nts. (16418827)	Patkar A.A.... Berrettini W.H.	2006	PRL
22	Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. (17106427)	Malison R.T.... Gelernter J.	2006	CLOCK, PER1, PER2
23	No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence. (16969273)	Weller A.E.... Berrettini W.H.	2006	PAWR
24	Effects of cortisol and cocaine on plasma prolactin a nd growth hormone levels in cocaine-dependent volunteers. (15833589)	Elman I.... Lukas S.E.	2005	PRL
25	Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (16314758)	Dahl J.P.... Berrettini W.H.	2005	HOMER1, HOMER2
26	Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence. (16094250)	Messas G.... Vallada H.	2005	DRD2, DRD3
27	A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. (16272961)	Guindalini C.... Breen G.	2005	GSTP1
28	DHEAS and POMS measures identify cocaine dependence treatment outcome. (15358439)	Wilkins J.N.... Setoda D.	2005	PRL
29	Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. (16184603)	Dahl J.P.... Berrettini W.H.	2005	PDYN
30	Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence. (15064918)	Patkar A.A.... Berrettini W.H.	2004	PRL
31	Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers. (15091312)	Patkar A.A.... Vergare M.J.	2004	SLC6A4
32	CALCYON gene variation, schizophrenia, and cocaine dependence. (14755439)	Luo X.... Gelernter J.	2004	CALY
33	Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. (15010698)	Martinez D.... Frankel W.G.	2004	DRD2
34	Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-depende nt patients and healthy volunteers. (12590403)	Patkar A.A.... Weinstein S.P.	2003	SLC6A4
35	Dopamine transporter as target for drug development of cocaine dependence medications. (14612141)	Dutta A.K.... Reith M.E.	2003	SLC6A3
36	Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter. (12773538)	Norregaard L.... Gether U.	2003	SLC6A3
37	A pilot trial of olanzapine for the treatment of cocaine dependence. (12757964)	Kampman K.M.... O'Brien C.P.	2003	HTR2C, DRD2
38	CSF CRH in abstinent cocaine-dependent patients. (12686370)	Roy A.... Gonzalez B.	2003	CRH
39	Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. (11992566)	Chen A.C.... Kreek M.J.	2002	PDYN
40	Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. (12057823)	Patkar A.A.... Weinstein S.P.	2002	SLC6A4
41	No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. (12218660)	Patkar A.A.... Weinstein S.P.	2002	SLC6A4
42	Quantitative medial temporal lobe brain morphology an d hypothalamic-pituitary-adrenal axis function in cocaine dependence: a prelimi nary report. (11173167)	Jacobsen L.K.... Kosten T.R.	2001	POMC
43	Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. (11900612)	Patkar A.A.... Weinstein S.P.	2001	SLC6A4
44	Disulfiram treatment for cocaine dependence in methad one-maintained opioid addicts. (10723850)	Petrakis I.L.... Rounsaville B.J.	2000	DBH
45	No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. (10023512)	Gelernter J.... Satel S.L.	1999	DRD2
46	Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. (10523822)	Comings D.E.... MacMurray J.P.	1999	DRD2, DRD3
47	Are neuroadaptations in D3 dopamine receptors linked to the development of cocaine dependence? (9154209)	Mash D.C.	1997	DRD3
48	No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. (12893467)	Freimer M.... Gelernter J.	1996	DRD3
49	Allelic association of the D2 dopamine receptor gene with cocaine dependence. (8261891)	Noble E.P.... Anglin M.D.	1993	DRD2
50	Acute effects of cocaine on plasma adrenocorticotropi c hormone, luteinizing hormone and prolactin levels in cocaine-dependent men. (1331401)	Mendelson J.H.... Rhoades E.	1992	PRL

Genes related to cocaine dependence according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
2	PDYN	prodynorphin	11.0	Publications
3	DRD3	dopamine receptor D3	11.0	Publications
4	OPRK1	opioid receptor, kappa 1	11.0	Publications
5	DRD2	dopamine receptor D2	11.0	Publications
6	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
7	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
8	POMC	proopiomelanocortin	11.0	Publications
9	CALY	calcyon neuron-specific vesicular protein	11.0	Publications
10	CDNF	cerebral dopamine neurotrophic factor	11.0	Publications
11	CARTPT	CART prepropeptide	11.0	Publications
12	ANKK1	ankyrin repeat and kinase domain containing 1	11.0	Publications
13	NPY5R	neuropeptide Y receptor Y5	11.0	Publications
14	NPY2R	neuropeptide Y receptor Y2	11.0	Publications
15	PER1	period homolog 1 (Drosophila)	11.0	Publications
16	HOMER2	homer homolog 2 (Drosophila)	11.0	Publications
17	CHRNA5	cholinergic receptor, nicotinic, alpha 5 (neuronal)	11.0	Publications
18	NPY1R	neuropeptide Y receptor Y1	11.0	Publications
19	PER2	period homolog 2 (Drosophila)	11.0	Publications
20	PAWR	PRKC, apoptosis, WT1, regulator	11.0	Publications
21	TACR3	tachykinin receptor 3	11.0	Publications
22	DRD4	dopamine receptor D4	11.0	Publications
23	GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	11.0	Publications
24	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
25	HOMER1	homer homolog 1 (Drosophila)	11.0	Publications
26	TPH2	tryptophan hydroxylase 2	11.0	Publications
27	CLOCK	clock homolog (mouse)	11.0	Publications
28	MAOB	monoamine oxidase B	11.0	Publications
29	DRD1	dopamine receptor D1	11.0	Publications
30	COMT	catechol-O-methyltransferase	11.0	Publications
31	PRL	prolactin	11.0	Publications
32	CRH	corticotropin releasing hormone	11.0	Publications
33	NPY	neuropeptide Y	11.0	Publications
34	GSTP1	glutathione S-transferase pi 1	11.0	Publications
35	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Publications
36	ACHE	acetylcholinesterase	11.0	Publications
37	OPRM1	opioid receptor, mu 1	-10.0	Publications

Pathways related to cocaine dependence according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.0	TPH2, SLC6A4
2	Circadian Clock in Mammals36	10.0	CLOCK, PER1, PER2
3	Tyrosine metabolism p.1 (dopamine)41	9.8	DBH, COMT, MAOB
4	Circadian rhythm - mammal20	9.8	PER2, PER1, CLOCK
5	Tyrosine metabolism p.1 (dopamine)10	9.8	DBH, COMT, MAOB
6	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	9.7	CHRNA5, DRD4, DRD3, DRD2, DRD1
7	Tyrosine metabolism20	9.7	MAOB, COMT, DBH
8	Selected targets of CREB110	9.6	PER2, PER1, PDYN, CRH, CARTPT
9	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.4	NPY5R, NPY2R, NPY1R, NPY, OPRK1, TACR3
10	Amine ligand-binding receptors38	9.3	DRD4, DRD3, DRD2, DRD1, HTR2C
11	Class A/1 (Rhodopsin-like receptors)38	9.3	NPY5R, NPY2R, NPY1R, NPY, OPRK1, PDYN
12	Dopamine-DARPP32 Feedback onto cAMP Pathway36	9.2	DRD4, DRD3, DRD2, DRD1, PAWR
13	Sympathetic Nerve Pathway (Neuroeffector Junction)34	9.0	NPY2R, NPY1R, NPY, DBH, ACHE
14	Neuroactive ligand-receptor interaction20	7.5	CNR1, CHRNA5, GABRA2, NPY5R, NPY2R, NPY1R

Compounds related to cocaine dependence according to GeneDecks:

(show top 50)    (show all 242)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.0	OPRK1, PDYN, CRH, ANKK1, CHRNA5
2	quinpirole32	9.7	DRD1, DRD2, CNR1, PDYN, SLC6A3, DRD3
3	bromocriptine32 9 9	11.6	POMC, PRL, DRD3, HTR2C
4	dopac32	9.4	DRD1, DRD3, COMT, OPRK1, DBH, MAOB
5	rotigotine32 9 9	11.4	DRD4, DRD3, DRD2, DRD1, MAOB
6	d amphetamine32	9.4	MAOB, DRD2, SLC6A3, SLC6A4, DRD1
7	methylphenidate32 9 9	11.3	SLC6A3, COMT, DRD4, DRD2, DRD1, MAOB
8	bupropion32 34 9 18 9	13.2	DRD2, DRD3, MAOB, ANKK1, NPY, SLC6A3
9	mptp32	9.2	DRD2, DRD3, DBH, MAOB, SLC6A3, DRD1
10	homovanillic acid32 18	10.0	CRH, COMT, MAOB, DBH, PRL, SLC6A4
11	spec-t32	8.9	MAOB, DRD1, CNR1, SLC6A4, TACR3, CRH
12	lisuride32 9 9	10.9	HTR2C, DRD2, DRD3, DRD4, PRL, DRD1
13	carbidopa32	8.9	PRL, DBH, COMT, MAOB, SLC6A3
14	quetiapine32 9 18 9	11.8	SLC6A3, DRD1, DRD2, DRD3, HTR2C, PRL
15	paliperidone32 9 9	10.8	DRD3, DRD2, DRD1, HTR2C, DRD4, PRL
16	mirtazapine32 34 9 9	11.8	SLC6A4, POMC, HTR2C, OPRK1, PRL, CRH
17	ropinirole32 9 9	10.8	DRD4, MAOB, DRD1, DRD3, COMT, HTR2C
18	heroin32 9 9	10.7	DRD2, CNR1, DRD3, DRD4, COMT, SLC6A4
19	6-hydroxydopamine32	8.7	DRD4, SLC6A3, NPY, DBH, PDYN, COMT
20	methamphetamine32 9 9	10.7	SLC6A4, SLC6A3, NPY, PDYN, COMT, DRD4
21	glutamate32	8.7	CNR1, HTR2C, DRD1, DRD2, DRD4, PDYN
22	pergolide32 9 9	10.7	DRD3, PRL, DRD4, COMT, DRD2, DRD1
23	morphine32 9 9	10.7	OPRK1, PDYN, SLC6A3, OPRM1, DBH, COMT
24	pramipexole32 9 9	10.7	SLC6A3, PRL, COMT, DRD4, DRD3, DRD2
25	cabergoline32 9 9	10.6	PRL, DRD4, DRD2, HTR2C, DRD3, DRD1
26	mhpg32	8.6	MAOB, SLC6A4, NPY, PRL, DBH, COMT
27	haloperidol32 34 9 9	11.6	MAOB, NPY, SLC6A3, SLC6A4, POMC, PRL
28	naloxone32 34 9 9	11.6	POMC, OPRM1, OPRK1, PDYN, CRH, CNR1
29	fenfluramine32 9 9	10.5	HTR2C, SLC6A4, PRL, POMC, NPY, CRH
30	maoa32	8.5	HTR2C, MAOB, TPH2, DRD2, SLC6A4, SLC6A3
31	risperidone32 34 9 18 9	12.5	SLC6A4, SLC6A3, PRL, COMT, DRD4, DRD3
32	amphetamine32 9 9	10.5	CNR1, SLC6A4, SLC6A3, NPY, POMC, OPRK1
33	naltrexone32 34 9 9	11.5	OPRK1, CRH, PRL, NPY, POMC, OPRM1
34	olanzapine32 34 9 18 9	12.5	DRD3, PRL, COMT, DRD4, DRD2, DRD1
35	opiate32	8.4	SLC6A4, SLC6A3, NPY, POMC, OPRK1, PRL
36	clomipramine32 34 9 9	11.4	PRL, SLC6A3, SLC6A4, GSTP1, HTR2C, CRH
37	clozapine32 34 9 9	11.3	SLC6A4, SLC6A3, POMC, OPRK1, PRL, DRD4
38	fluoxetine32 34 9 9	11.3	CNR1, MAOB, SLC6A4, SLC6A3, PRL, CRH
39	catecholamine32	8.3	MAOB, DRD3, DRD4, POMC, NPY, COMT
40	sulpiride32 9 9	10.0	DRD1, HTR2C, DRD2, DRD3, SLC6A3, NPY
41	apomorphine32 9 9	10.0	SLC6A3, PRL, COMT, DRD4, DRD3, DRD2
42	levodopa32 9 9	9.9	SLC6A3, OPRK1, PRL, DBH, PDYN, COMT
43	epinephrine32 9 18 9	10.6	DRD4, PRL, DBH, PDYN, GSTP1, SLC6A4
44	gaba32 42	8.5	SLC6A4, SLC6A3, NPY, POMC, OPRK1, DBH
45	nmda32 42	8.0	DRD2, SLC6A4, SLC6A3, CNR1, MAOB, HTR2C
46	acetylcholine32 9 18 9	9.9	POMC, PDYN, CRH, DRD2, DRD1, HTR2C
47	5-hydroxytryptamine32	6.9	SLC6A4, SLC6A3, NPY, POMC, PRL, DBH
48	cocaine32 9 9	8.5	DRD3, DRD2, DRD1, CARTPT, HTR2C, MAOB
49	norepinephrine32 9 18 9	9.5	DRD1, CNR1, MAOB, HTR2C, DBH, SLC6A3
50	dopamine32 9 18 9	7.5	DBH, CRH, DRD4, DRD3, DRD2, DRD1

Cellular components related to cocaine dependence according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	9.5	DRD1, DRD4, DBH, SLC6A3, CHRNA5
2	axon	GO:030424	9.2	GABRA2, SLC6A3, NPY1R, DRD2, DRD1
3	integral to plasma membrane	GO:005887	7.5	CNR1, SLC6A4, SLC6A3, NPY5R, NPY2R, NPY1R
4	plasma membrane	GO:005886	5.1	OPRK1, OPRM1, NPY1R, NPY2R, NPY5R, SLC6A3

Biological processes related to cocaine dependence according to GeneDecks:

(show all 47)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of dopamine receptor signaling pathway	GO:060160	10.5	DRD3, DRD2
2	response to iron ion	GO:010039	10.5	DRD2, DBH, SLC6A3
3	response to histamine	GO:034776	10.4	DRD4, DRD3, DRD2
4	behavioral response to ethanol	GO:048149	10.4	DBH, DRD4, DRD2
5	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.4	DRD4, DRD3, DRD2
6	negative regulation of protein secretion	GO:050709	10.4	DRD4, DRD3, DRD2
7	arachidonic acid secretion	GO:050482	10.4	DRD4, DRD3, DRD2
8	positive regulation of dopamine uptake involved in synaptic transmission	GO:051586	10.4	DRD4, DRD2
9	negative regulation of circadian sleep/wake cycle, sleep	GO:042321	10.3	DRD1, DRD2
10	negative regulation of adenylate cyclase activity	GO:007194	10.3	DRD4, DRD3, DRD2
11	regulation of dopamine uptake involved in synaptic transmission	GO:051584	10.3	DRD3, DRD2, DRD1
12	regulation of cAMP metabolic process	GO:030814	10.3	DRD3, DRD2
13	dopamine catabolic process	GO:042420	10.3	SLC6A3, DBH, COMT
14	response to nicotine	GO:035094	10.3	SLC6A3, DRD2, CNR1
15	social behavior	GO:035176	10.3	SLC6A4, DBH, DRD4, DRD3
16	prepulse inhibition	GO:060134	10.2	SLC6A3, DRD3, DRD2, DRD1
17	positive regulation of blood pressure	GO:045777	10.2	CNR1, CARTPT, TACR3
18	visual learning	GO:008542	10.2	DBH, DRD3, DRD2, DRD1
19	response to morphine	GO:043278	10.2	TACR3, DRD3, DRD2, CNR1
20	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	GO:007193	10.2	OPRK1, NPY1R, NPY2R
21	outflow tract morphogenesis	GO:003151	10.2	NPY5R, NPY2R, NPY1R
22	phospholipase C-activating dopamine receptor signaling pathway	GO:060158	10.1	DRD2, DRD1
23	behavioral response to cocaine	GO:048148	10.1	DRD1, DRD2, DRD3, DRD4
24	response to estradiol stimulus	GO:032355	10.1	SLC6A4, NPY1R, DBH, TACR3
25	dopamine metabolic process	GO:042417	10.1	DRD1, DRD2, DRD3, DRD4
26	response to cocaine	GO:042220	10.1	SLC6A3, TACR3, DRD3, DRD2, CNR1
27	locomotory behavior	GO:007626	10.1	SLC6A3, NPY2R, NPY1R, DBH, DRD3, DRD2
28	circadian regulation of gene expression	GO:032922	10.1	PER1, DRD3, DRD2, CARTPT, CLOCK
29	regulation of multicellular organism growth	GO:040014	10.1	NPY1R, PRL, DRD3
30	memory	GO:007613	10.0	CNR1, DRD1, DBH, SLC6A4
31	cerebral cortex GABAergic interneuron migration	GO:021853	10.0	DRD2, DRD1
32	regulation of dopamine metabolic process	GO:042053	10.0	SLC6A3, TACR3, DRD4, DRD1
33	response to amphetamine	GO:001975	10.0	DBH, DRD4, DRD3, DRD2, DRD1
34	response to ethanol	GO:045471	10.0	SLC6A3, DRD3, MAOB, CNR1
35	negative regulation of blood pressure	GO:045776	9.9	CNR1, DRD2, DRD3, NPY
36	regulation of feeding behavior	GO:060259	9.9	CNR1, TACR3
37	neuropeptide signaling pathway	GO:007218	9.9	CARTPT, PDYN, POMC, NPY
38	behavior	GO:007610	9.9	NPY, OPRK1, CNR1
39	circadian rhythm	GO:007623	9.9	PER2, PER1, SLC6A4, TPH2, CLOCK
40	fear response	GO:042596	9.9	DBH, DRD4
41	synaptic transmission, dopaminergic	GO:001963	9.7	CRH, DRD4, DRD3, DRD2, DRD1
42	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	9.6	CNR1, DRD1, NPY, NPY1R
43	neurotransmitter biosynthetic process	GO:042136	9.5	SLC6A3, ACHE, COMT
44	synapse assembly	GO:007416	9.2	DRD1, DRD2, ACHE
45	feeding behavior	GO:007631	9.1	NPY1R, NPY, CRH, DRD2, HTR2C
46	response to drug	GO:042493	8.8	SLC6A4, SLC6A3, COMT, DRD3, DRD2, DRD1
47	synaptic transmission	GO:007268	7.0	HTR2C, CHRNA5, GABRA2, SLC6A3, NPY, OPRK1

Molecular functions related to cocaine dependence according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	monoamine transmembrane transporter activity	GO:008504	10.2	SLC6A3, SLC6A4
2	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.1	DRD4, DRD3, DRD2
3	peptide YY receptor activity	GO:001601	10.0	NPY1R, NPY2R, NPY5R
4	pancreatic polypeptide receptor activity	GO:001602	10.0	NPY1R, NPY5R
5	neuropeptide Y receptor activity	GO:004983	10.0	NPY5R, NPY2R, NPY1R
6	dopamine binding	GO:035240	9.8	DRD1, DRD2, DRD3, DRD4, SLC6A3
7	dopamine receptor activity	GO:004952	9.6	DRD1, DRD4
8	drug binding	GO:008144	8.9	SLC6A3, DRD4, DRD3, DRD2, DRD1, HTR2C