MCID: CCN001
MIFTS: 54

Cocaine Dependence malady

Mental diseases category

Summaries for Cocaine Dependence

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine overdose... more...

MalaCards: Cocaine Dependence is related to personality disorder and antisocial personality disorder. An important gene associated with Cocaine Dependence is PDYN (prodynorphin), and among its related pathways are Monoamine GPCRs and Monoamine Transport. The compounds [3h]nemonapride and 7-oh-dpat have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related mouse phenotypes are taste/olfaction and skeleton.

Disease Ontology:9 A drug dependence that is a psychological dependency on the regular use of cocaine.

Aliases & Classifications for Cocaine Dependence

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

cocaine dependence 9 11 46 63


External Ids:

Disease Ontology9 DOID:9975
ICD9CM28 304.2, 304.20
NCIt41 C34492
MeSH36 D019970

Related Diseases for Cocaine Dependence

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.9DRD3, SLC6A3, DRD2
2antisocial personality disorder30.8SLC6A3, DRD2
3alcohol dependence30.5DRD2, OPRK1
4schizophrenia30.4SLC6A3, OPRK1, DBH, PDYN, DRD3, DRD2
5attention deficit hyperactivity disorder30.4SLC6A3, DRD2, DBH
6bipolar disorder30.4PDYN, DRD3, DRD2, OPRK1, SLC6A3, SLC18A2
7heroin dependence30.2DRD2
8cocaine abuse30.2OPRK1, DBH, DRD2, SLC6A3
9nicotine dependence30.2DRD2
10schizoaffective disorder30.1DRD3, DRD2
11pathological gambling30.1SLC6A3, DRD3, DRD2
12alcohol abuse30.1DRD3, DRD2, SLC6A3
13substance dependence30.0SLC6A3, DRD3, PDYN, DRD2
14ischemia30.0SLC6A3, OPRK1, PDYN, DRD2
15drug dependence29.9PDYN, SLC6A3, OPRK1, DRD2, DRD3
16drug addiction29.8SLC18A2, SLC6A3, OPRK1, DRD2, DRD3, PDYN
17mood disorder29.7POMC, DBH, SLC18A2, SLC6A3, DRD2, DRD3
18blindness10.8
19cerebritis10.3
20cannabis dependence10.3
21post-traumatic stress disorder10.3
22delusional disorder10.1DRD2
23neuroleptic malignant syndrome10.1DRD2
24torsion dystonia10.1DBH
25oppositional defiant disorder10.1SLC6A3
26amnestic disorder10.1PDYN, OPRK1
27striatonigral degeneration10.0DRD2, SLC6A3
28essential tremor10.0SLC6A3, DRD3
29progressive supranuclear palsy10.0DRD2, SLC6A3
30major depressive disorder10.0
31borderline personality disorder10.0
32alexithymia10.0
33cannabis abuse10.0
34congenital syphilis10.0
35dystonia10.0
36hyperthyroidism10.0
37prostatitis10.0
38syphilis10.0
39wilson disease10.0DRD2, SLC6A3
40memory impairment10.0PDYN, SLC6A3
41gilles de la tourette syndrome10.0SLC6A3, DRD2
42acromegaly10.0DRD2, POMC
43anxiety disorder10.0SLC6A3, DRD2
44prolactinoma10.0DRD2, POMC
45pituitary tumors10.0DRD2, POMC
46hyperprolactinemia10.0DBH, POMC, DRD2
47substance abuse10.0DRD2, DRD3, SLC6A3
48pain agnosia10.0OPRK1, POMC, PDYN
49conduct disorder10.0DRD2, DBH, SLC6A3
50multiple system atrophy10.0SLC6A3, DRD2, DBH

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to cocaine dependence

Symptoms for Cocaine Dependence

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Drugs & Therapeutics for Cocaine Dependence

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cocaine Dependence

Drug clinical trials:

Search ClinicalTrials for Cocaine Dependence

Search NIH Clinical Center for Cocaine Dependence

Search CenterWatch for Cocaine Dependence

Genetic Tests for Cocaine Dependence

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Anatomical Context for Cocaine Dependence

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34MalaCards
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MalaCards organs/tissues related to Cocaine Dependence:

34
Brain, Heart, Testes, Pituitary, Monocytes, Prostate, Cortex, Temporal lobe

Animal Models for Cocaine Dependence or affiliated genes

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38MGI
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Publications for Cocaine Dependence

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53PubMed
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Articles related to Cocaine Dependence:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Heightened D3 Dopamine Receptor Levels in Cocaine Dependence and Contributions to the Addiction Behavioral Phenotype: A Positron Emission Tomography Study with [(11)C]-(+)-PHNO. (23921256)
2014
2
Attention deficit hyperactivity disorder in cocaine-dependent adults: a psychiatric comorbidity analysis. (23952892)
2013
3
Individual Differences in Attentional Bias Associated with Cocaine Dependence Are Related to Varying Engagement of Neural Processing Networks. (24196947)
2013
4
Negative urgency, disinhibition and reduced temporal pole gray matter characterize the comorbidity of cocaine dependence and personality disorders. (23466222)
2013
5
Functional brain networks associated with cognitive control, cocaine dependence, and treatment outcome. (22775772)
2013
6
Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes. (24312228)
2013
7
Stochastic dynamic causal modeling of working memory connections in cocaine dependence. (23151990)
2012
8
Association study of the I^-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. (22472784)
2012
9
Dopamine agonists for the treatment of cocaine dependence. (22161376)
2011
10
A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. (21849985)
2011
11
Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands. (21854580)
2011
12
Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. (20170711)
2010
13
White matter integrity is associated with treatment outcome measures in cocaine dependence. (20393459)
2010
14
Review of treatment for cocaine dependence. (20088819)
2010
15
Cocaine dependence and concurrent marijuana use: a comparison of clinical characteristics. (19462304)
2009
16
WITHDRAWN: Carbamazepine for cocaine dependence. (19160205)
2009
17
Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (18828811)
2008
18
Efficacy of central nervous system stimulant treatment for cocaine dependence: a systematic review and meta-analysis of randomized controlled clinical trials. (18031423)
2007
19
Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? (17671965)
2007
20
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. (17403976)
2007
21
Monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release as candidate "agonist" medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine self-administration in rhesus monkeys. (17071819)
2007
22
A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. (16631323)
2006
23
Assessment of cognitive functioning of methadone-maintenance patients: impact of adult ADHD and current cocaine dependence. (17088222)
2006
24
Changes in tobacco smoking following treatment for cocaine dependence. (16595320)
2006
25
Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. (16759340)
2006
26
Nefazodone in out-patient treatment of inhaled cocaine dependence: a randomized double-blind placebo-controlled trial. (15784063)
2005
27
Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response. (15804873)
2005
28
What aspects of treatment matter to the patient in the treatment of cocaine dependence? (15450650)
2004
29
Recent advances in the pharmacotherapy of cocaine dependence. (15355754)
2004
30
Apathy syndrome in cocaine dependence. (11850056)
2002
31
Cocaine withdrawal severity and urine toxicology results from treatment entry predict outcome in medication trials for cocaine dependence. (11817766)
2002
32
Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. (12022962)
2002
33
Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression. (12167556)
2002
34
Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. (11173167)
2001
35
Anger management group treatment for cocaine dependence: preliminary outcomes. (10852354)
2000
36
Counselor prompts to increase condom taking during treatment for cocaine dependence. (9567735)
1998
37
Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects. (9787120)
1998
38
Increasing treatment adherence among outpatients with depression and cocaine dependence: results of a pilot study. (9812129)
1998
39
Structured interview versus self-report test vantages for the assessment of personality pathology in cocaine dependence. (9203112)
1997
40
Replacement medication for cocaine dependence: methylphenidate. (9408812)
1997
41
Overview of potential treatment medications for cocaine dependence. (9467792)
1997
42
Subclinical neurological and neurovascular deficits in cocaine dependence. Gender and psychosocial considerations. (9369998)
1997
43
Are neuroadaptations in D3 dopamine receptors linked to the development of cocaine dependence? (9154209)
1997
44
Carbamazepine treatment of cocaine dependence: a placebo-controlled trial. (7555620)
1995
45
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. (8082553)
1994
46
Combinations of treatment modalities and therapeutic outcome for cocaine dependence. (8289900)
1993
47
Allelic association of the D2 dopamine receptor gene with cocaine dependence. (8261891)
1993
48
Pharmacological approaches to cocaine dependence. (1498999)
1992
49
Developing and evaluating new treatments for alcoholism and cocaine dependence. (1589603)
1992
50
The prevalence of marijuana (cannabis) use and dependence in cocaine dependence. (2234615)
1990

Variations for Cocaine Dependence

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Expression for genes affiliated with Cocaine Dependence

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for genes affiliated with Cocaine Dependence

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 31KEGG
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Pathways related to Cocaine Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DRD2, DRD3
2
Show member pathways
Serotonin Transporter Activity39
9.4SLC6A3, DBH
39.2DBH, SLC18A2
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
8.9DRD3, DRD2, SLC18A2
5
Show member pathways
8.6SLC18A2, SLC6A3, DRD2
6
Show member pathways
8.3POMC, PDYN, DRD3, DRD2, OPRK1
7
Show member pathways
8.3OPRK1, DRD2, DRD3, PDYN, POMC
8
Show member pathways
8.3PDYN, DRD2, SLC6A3, SLC18A2
9
Show member pathways
8.3SLC18A2, SLC6A3, DRD2, PDYN
10
Show member pathways
8.2SLC18A2, SLC6A3, DRD2, DRD3

Compounds for genes affiliated with Cocaine Dependence

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Cocaine Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1[3h]nemonapride309.7DRD3, DRD2
27-oh-dpat309.6DRD2, DRD3
3dopac469.4OPRK1, DBH, DRD3
4(-)-n-porphynorapomorphine309.4DRD3, DRD2
5raclopride46 3010.4SLC6A3, DRD3, DRD2
6etorphine46 30 1211.4OPRK1, POMC, PDYN
7piperazine46 1210.4DRD2, DRD3, SLC6A3
8alpha-methyl-p-tyrosine469.3DBH, SLC6A3, DRD2
9sulpiride46 30 1211.1SLC6A3, DRD2, DRD3, PDYN
10apomorphine30 46 1211.1DRD3, SLC6A3, DRD2
11quinpirole46 3010.1SLC6A3, PDYN, DRD3, DRD2
12methadone52 46 1211.1OPRK1, POMC, PDYN, DRD2
13duloxetine46 52 30 1212.0SLC18A2, SLC6A3, DRD3
14tetrabenazine46 30 62 52 1213.0SLC18A2, SLC6A3, DRD2
15bromocriptine46 30 1210.9DRD3, POMC, DRD2, SLC6A3
16methylphenidate46 52 1210.9DRD2, SLC6A3, SLC18A2
17maoa468.9DRD2, POMC, SLC6A3, DBH
18reserpine46 30 1210.9DRD2, SLC6A3, SLC18A2
19ketamine46 30 1210.8SLC18A2, SLC6A3, DRD2
20acth468.8OPRK1, POMC, PDYN, DBH
21paroxetine46 52 30 1211.8SLC6A3, DRD3, SLC18A2
226-hydroxydopamine468.7DRD2, DRD3, PDYN, DBH, SLC6A3
23pramipexole46 30 52 1211.6SLC6A3, SLC18A2, DRD3, DRD2
24spec-t468.6SLC18A2, SLC6A3, DRD2
25bupropion52 46 25 1211.6DRD3, DRD2, SLC18A2, SLC6A3
26amine468.6DRD3, DBH, OPRK1, SLC18A2
27lead468.6OPRK1, SLC18A2, DRD3, DBH
28imipramine46 30 52 25 1212.5SLC6A3, DRD3, DBH, SLC18A2
29morphine46 52 30 1211.5DRD2, SLC6A3, DBH, PDYN, OPRK1
30clozapine46 30 52 1211.4DRD3, DRD2, OPRK1, POMC, SLC6A3
31catecholamine468.4DRD3, SLC18A2, PDYN, POMC, DBH
32methamphetamine46 52 1210.3SLC18A2, SLC6A3, DRD2, PDYN, DRD3
33epinephrine46 25 1210.3PDYN, SLC18A2, POMC, DRD2, DBH
34mptp468.2DBH, DRD3, DRD2, SLC6A3, SLC18A2
35haloperidol46 52 30 3 1212.1DRD2, POMC, DRD3, SLC6A3, SLC18A2
36heroin46 52 1210.1SLC6A3, DRD2, POMC, PDYN, DRD3, OPRK1
375-hydroxytryptamine468.0SLC18A2, SLC6A3, DRD2, DBH, POMC
38sodium46 258.9OPRK1, SLC6A3, SLC18A2, DRD3, DBH
39nmda46 308.8SLC6A3, DRD3, DRD2, SLC18A2, OPRK1, PDYN
40opiate467.7SLC6A3, PDYN, OPRK1, DRD2, DRD3, DBH
41amphetamine46 52 129.7PDYN, DRD2, OPRK1, SLC6A3, SLC18A2, POMC
42cysteine467.6SLC6A3, OPRK1, DRD3, DBH, SLC18A2, PDYN
43levodopa46 128.4DRD2, SLC18A2, SLC6A3, OPRK1, DRD3, PDYN
44nicotine46 30 52 1210.4OPRK1, SLC6A3, SLC18A2, DRD2, DRD3, PDYN
45glutamate467.3SLC18A2, OPRK1, DRD2, PDYN, DBH, DRD3
46gaba467.2PDYN, DRD2, OPRK1, POMC, SLC18A2, DBH
47acetylcholine46 52 30 25 1211.2SLC18A2, DRD2, OPRK1, PDYN, POMC, DBH
48norepinephrine46 25 128.9POMC, DBH, SLC6A3, OPRK1, DRD2, DRD3
49cocaine46 127.8OPRK1, SLC18A2, SLC6A3, DRD2, DRD3, POMC
50dopamine46 30 25 129.8DRD3, SLC18A2, SLC6A3, DBH, OPRK1, POMC

GO Terms for genes affiliated with Cocaine Dependence

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17Gene Ontology
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Cellular components related to Cocaine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.7DRD2, DRD3
2secretory granule lumenGO:0347749.5DBH, POMC
3synaptic vesicle membraneGO:0306728.9SLC18A2, DRD2
4integral component of plasma membraneGO:0058877.8SLC18A2, SLC6A3, OPRK1, DRD2, DRD3
5plasma membraneGO:0058867.3PDYN, DRD3, DRD2, OPRK1, SLC6A3, SLC18A2

Biological processes related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotion involved in locomotory behaviorGO:09032510.1DRD2, DRD3
2response to histamineGO:03477610.1DRD2, DRD3
3negative regulation of dopamine receptor signaling pathwayGO:06016010.1DRD2, DRD3
4regulation of dopamine uptake involved in synaptic transmissionGO:05158410.1DRD3, DRD2
5regulation of cAMP metabolic processGO:03081410.1DRD3, DRD2
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD3, DRD2
7dopamine metabolic processGO:04241710.0DRD2, DRD3
8negative regulation of protein secretionGO:05070910.0DRD3, DRD2
9G-protein coupled receptor internalizationGO:00203110.0DRD3, DRD2
10synaptic transmission, dopaminergicGO:00196310.0DRD3, DRD2
11behavioral response to cocaineGO:04814810.0DRD3, DRD2
12arachidonic acid secretionGO:05048210.0DRD3, DRD2
13positive regulation of renal sodium excretionGO:03581510.0DRD3, DRD2
14circadian regulation of gene expressionGO:03292210.0DRD2, DRD3
15behavioral response to ethanolGO:04814910.0DBH, DRD2
16response to morphineGO:0432789.9DRD2, DRD3
17negative regulation of adenylate cyclase activityGO:0071949.9DRD3, DRD2
18negative regulation of protein kinase B signalingGO:0518989.9DRD2, DRD3
19negative regulation of blood pressureGO:0457769.9DRD3, DRD2
20positive regulation of cytokinesisGO:0324679.8DRD2, DRD3
21adenohypophysis developmentGO:0219849.8SLC6A3, DRD2
22dopamine catabolic processGO:0424209.8DBH, SLC6A3
23response to iron ionGO:0100399.7DRD2, SLC6A3
24response to nicotineGO:0350949.7SLC6A3, DRD2
25visual learningGO:0085429.6DBH, DRD3, DRD2
26cellular calcium ion homeostasisGO:0068749.6DRD2, DRD3
27positive regulation of multicellular organism growthGO:0400189.6SLC6A3, DRD2
28response to ethanolGO:0454719.5SLC6A3, DRD3
29prepulse inhibitionGO:0601349.5SLC6A3, DRD2, DRD3
30sensory perception of smellGO:0076089.4SLC6A3, DRD2
31monoamine transportGO:0158449.4SLC18A2, SLC6A3
32response to drugGO:0424939.1DRD3, DRD2, SLC6A3
33glucose homeostasisGO:0425938.9SLC18A2, DBH
34response to amphetamineGO:0019758.8DBH, DRD3, DRD2, SLC18A2
35response to cocaineGO:0422208.7DRD3, DRD2, SLC6A3, SLC18A2
36synaptic transmissionGO:0072688.5DBH, OPRK1, SLC6A3, SLC18A2
37locomotory behaviorGO:0076267.7SLC18A2, SLC6A3, OPRK1, DRD2, DRD3, DBH

Molecular functions related to Cocaine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.4DRD2, DRD3
2monoamine transmembrane transporter activityGO:0085049.0SLC18A2, SLC6A3
3dopamine bindingGO:0352409.0DRD3, DRD2, SLC6A3
4drug bindingGO:0081448.2SLC18A2, SLC6A3, DRD2, DRD3

Products for genes affiliated with Cocaine Dependence

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Sources for Cocaine Dependence

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet