MCID: CCN001
MIFTS: 56

Cocaine Dependence malady

Summaries for Cocaine Dependence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine overdose... more...

MalaCards: Cocaine Dependence is related to alcohol dependence and drug dependence. An important gene associated with Cocaine Dependence is PDYN (prodynorphin), and among its related pathways are Dopamine receptors and Monoamine Transport. The compounds u50488 and nmda have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related mouse phenotypes are taste/olfaction and adipose tissue.

Disease Ontology:8 A drug dependence that is a psychological dependency on the regular use of cocaine.

Aliases & Classifications for Cocaine Dependence

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

cocaine dependence 8 10 44 60


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Disease Ontology8 DOID:9975
ICD9CM27 304.20, 304.2
NCIt39 C34492
MeSH34 D019970

Related Diseases for Cocaine Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.0DRD2, GABRA2, SLC6A4, ANKK1, OPRM1, OPRK1
2drug dependence31.0OPRK1, OPRM1, SLC6A3, SLC6A4, PDYN, DRD2
3heroin dependence30.8DRD2, ANKK1
4personality disorder30.8DRD2, SLC6A4, DRD3, SLC6A3
5cocaine abuse30.8DRD2, OPRK1, DBH, SLC6A3, SLC6A4
6antisocial personality disorder30.6ANKK1, SLC6A3, SLC6A4, DRD2
7schizophrenia30.6CALY, PDYN, DBH, SLC6A3, SLC6A4, DRD2
8bipolar disorder30.6DRD2, SLC6A4
9opiate dependence30.6OPRM1
10substance dependence30.5OPRM1, SLC6A3, SLC6A4, DRD2, PDYN, DRD3
11nicotine dependence30.4SLC6A4, ANKK1, DRD2
12attention deficit hyperactivity disorder30.3DRD2, DBH, SLC6A4, SLC6A3, SLC18A2
13alexithymia30.0ANKK1
14pathological gambling30.0DRD3, DRD2, SLC6A3
15schizoaffective disorder30.0SLC6A4, DRD2, DRD3
16ischemia30.0DRD2, PDYN, SLC6A3, OPRK1
17alcohol abuse30.0SLC6A3, OPRM1, DRD3, DRD2, SLC6A4
18mood disorder30.0DBH, DRD3, POMC, SLC18A2, SLC6A3, SLC6A4
19dependent personality disorder10.6
20cannabis dependence10.5
21cerebritis10.3
22post-traumatic stress disorder10.2
23major depressive disorder10.0
24borderline personality disorder10.0
25cannabis abuse10.0
26bipolar i disorder10.0
27congenital syphilis10.0
28hyperthyroidism10.0
29prostatitis10.0
30sexual disorder10.0
31syphilis10.0
32restless legs syndrome10.0DRD2
33bulimia nervosa10.0SLC6A4
34eating disorder10.0SLC6A4
35prion disease10.0POMC
36neuroleptic malignant syndrome10.0DRD2
37fibromyalgia10.0SLC6A4
38anorexia nervosa10.0SLC6A4, POMC
39neuroblastoma10.0DBH, OPRM1
40obsessive-compulsive personality disorder10.0SLC6A4
41delusional disorder10.0DRD2
42alcoholic psychosis10.0SLC6A4
43essential hypertension10.0DBH
44wilson disease10.0SLC6A3, DRD2
45anxiety disorder10.0SLC6A4
46constipation10.0OPRM1, SLC6A4
47gilles de la tourette syndrome10.0SLC6A3, DRD2
48chronic fatigue syndrome10.0POMC, SLC6A4
49dementia10.0OPRM1, OPRK1, SLC6A3
50hypertension10.0SLC6A4, POMC, DBH

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to cocaine dependence

Clinical Features for Cocaine Dependence

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Drugs & Therapeutics for Cocaine Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cocaine Dependence

Drug clinical trials:

Search ClinicalTrials for Cocaine Dependence

Search NIH Clinical Center for Cocaine Dependence

Search CenterWatch for Cocaine Dependence

Genetic Tests for Cocaine Dependence

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Anatomical Context for Cocaine Dependence

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32MalaCards
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MalaCards organs/tissues related to Cocaine Dependence:

32
Brain, Heart, Pituitary, Testes, Cortex, Prostate, Monocytes, Temporal lobe, Subthalamic nucleus

Animal Models for Cocaine Dependence or affiliated genes

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36MGI
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Publications for Cocaine Dependence

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50PubMed
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Articles related to Cocaine Dependence:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Neural correlates of reward-based spatial learning in persons with cocaine dependence. (23917430)
2014
2
Functional Status of the Serotonin 5-HT2C Receptor (5-HT2CR) Drives Interlocked Phenotypes that Precipitate Relapse-Like Behaviors in Cocaine Dependence. (23939424)
2014
3
Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample. (24120036)
2013
4
The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study. (23306096)
2013
5
Re-appraisal of negative emotions in cocaine dependence: dysfunctional corticolimbic activation and connectivity. (22978709)
2012
6
Efficacy of contingency management for cocaine dependence treatment: a review of the evidence. (23244344)
2012
7
Extended-release mixed amphetamine salts and topiramate for cocaine dependence: a randomized controlled trial. (22795453)
2012
8
Psychostimulant treatment of cocaine dependence. (22640764)
2012
9
Acoustic startle reduction in cocaine dependence persists for 1 year of abstinence. (21161186)
2011
10
Psychoticism and neuroticism predict cocaine dependence and future cocaine use via different mechanisms. (21306838)
2011
11
WITHDRAWN: Antidepressants for cocaine dependence. (20166064)
2010
12
Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals. (19836169)
2010
13
New treatments for cocaine dependence: a focused review. (17927843)
2008
14
Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? (17671965)
2007
15
Assessment of cognitive functioning of methadone-maintenance patients: impact of adult ADHD and current cocaine dependence. (17088222)
2006
16
Pills for speedballing or cocaine dependence. (16731254)
2006
17
Cocaine dependence and PTSD: a pilot study of symptom interplay and treatment preferences. (15951125)
2006
18
Nefazodone in out-patient treatment of inhaled cocaine dependence: a randomized double-blind placebo-controlled trial. (15784063)
2005
19
Pharmacotherapy and other treatments for cocaine abuse and dependence. (16639150)
2005
20
Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function. (16185095)
2005
21
Prize reinforcement contingency management for cocaine dependence: integration with group therapy in a methadone clinic. (15796645)
2005
22
Participants receiving dehydroepiandrosterone during treatment for cocaine dependence show high rates of cocaine use in a placebo-controlled pilot study. (15122957)
2004
23
Effects of acute cortisol and cocaine administration on attention, recall and recognition task performance in individuals with cocaine dependence. (15378675)
2004
24
Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. (15010698)
2004
25
Lamotrigine in patients with bipolar disorder and cocaine dependence. (12633129)
2003
26
Apathy syndrome in cocaine dependence. (11850056)
2002
27
Sustained release dextroamphetamine (15-30 mg but not 30-60 mg) improved retention in patients with cocaine dependence. (12026896)
2002
28
A comparison of contingency management and cognitive-behavioral approaches during methadone maintenance treatment for cocaine dependence. (12215081)
2002
29
Adverse outcomes in a controlled trial of pergolide for cocaine dependence. (11286433)
2001
30
Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. (10862808)
2000
31
Cocaine dependence with and without comorbid depression: a comparison of patient characteristics. (10940546)
2000
32
'Research' versus 'real-world' patients: representativeness of participants in clinical trials of treatments for cocaine dependence. (10217557)
1999
33
A national evaluation of treatment outcomes for cocaine dependence. (10359464)
1999
34
Structured interview versus self-report test vantages for the assessment of personality pathology in cocaine dependence. (9203112)
1997
35
Management of clinical trials with new medications for cocaine dependence and abuse. (9467794)
1997
36
Monetary reinforcement of abstinence from cocaine among mentally ill patients with cocaine dependence. (9175190)
1997
37
Measuring adherence and competence of dynamic therapists in the treatment of cocaine dependence. (9058557)
1997
38
Management of cocaine abuse and dependence. (8596599)
1996
39
A quasi-experimental comparison of the effectiveness of 6- versus 12-hour per week outpatient treatments for cocaine dependence. (8551291)
1996
40
Psychomotor and electroencephalographic sequelae of cocaine dependence. (8809854)
1996
41
Carbamazepine treatment for cocaine dependence. (7555622)
1995
42
Fluoxetine is ineffective for treatment of cocaine dependence or concurrent opiate and cocaine dependence: two placebo-controlled double-blind trials. (7635993)
1995
43
Why publish three negative articles on carbamazepine as a medication for the treatment of cocaine dependence? (7555619)
1995
44
Fluoxetine for cocaine dependence in methadone maintenance: quantitative plasma and urine cocaine/benzoylecgonine concentrations. (8376611)
1993
45
Depression as a prognostic factor for pharmacological treatment of cocaine dependence. (1775608)
1991
46
Chemical aversion therapy in the treatment of cocaine dependence as part of a multimodal treatment program: treatment outcome. (2313768)
1990
47
Cocaine abuse and dependence. (2193362)
1990
48
Outcomes of cocaine-dependence treatment. (2640977)
1989
49
The diagnosis of alcohol, cocaine, and other drug dependence in an inpatient treatment population. (2709471)
1989
50
Cocaine dependence. (2658744)
1989

Genetic Variations for Cocaine Dependence

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Expression for genes affiliated with Cocaine Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for genes affiliated with Cocaine Dependence

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD3, DRD2
210.2DBH, SLC6A3, SLC6A4
3
Hide members
10.2DRD2, DRD3, SLC18A2
410.2PER1, PDYN, CARTPT
5
Hide members
10.1CPLX4, SLC18A2, SLC6A4
610.1SLC18A2, SLC6A3, DRD2, PDYN
7
Hide members
10.1PDYN, DRD2, SLC6A3, SLC18A2
8
Hide members
10.1DRD2, DRD3, SLC6A4, SLC18A2
9
Hide members
10.1NPY1R, NPY2R, DBH, SLC18A2
10
Hide members
10.0OPRM1, OPRK1, NPY5R, NPY2R, NPY1R
11
Hide members
9.7PDYN, NPY1R, NPY2R, NPY5R, DRD2, DRD3
12
Hide members
9.6PER1, CALY, DRD2, DRD3, GABRA2, OPRM1
13
Hide members
9.5PDYN, NPY1R, NPY2R, NPY5R, DRD2, DRD3

Compounds for genes affiliated with Cocaine Dependence

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Cocaine Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 253)
idCompoundScoreTop Affiliating Genes
1u5048844 2811.5OPRK1, PDYN, OPRM1
2nmda44 2811.5PDYN, OPRK1, SLC6A3, OPRM1
3piperazine44 1111.5DRD3, OPRM1, SLC6A3, DRD2
4sulpiride44 28 1112.5SLC6A3, DRD3, DRD2, PDYN
5duloxetine44 49 28 1113.5SLC18A2, SLC6A4, SLC6A3, DRD3
6etorphine44 28 1112.5PDYN, OPRK1, POMC, OPRM1
72beta-carbomethoxy-3beta-(4-iodophenyl)tropane4410.5SLC6A3, SLC6A4, SLC18A2
8methylphenidate44 49 1112.5SLC6A3, SLC18A2, DRD2, SLC6A4
9maoa4410.5DBH, SLC6A4, SLC6A3, POMC, DRD2
10[leu31,pro34]pyy (human)2810.5NPY5R, NPY2R, NPY1R
11[ala31,aib32]npy (pig)2810.4NPY1R, NPY2R, NPY5R
12quinpirole44 2811.4PDYN, SLC6A3, DRD2, DRD3
13risperidone28 44 49 59 11 2415.4SLC6A4, SLC6A3, ANKK1, DRD3, DRD2
14nisoxetine44 2811.4SLC18A2, SLC6A3, SLC6A4
15ketamine44 28 1112.4SLC6A4, SLC18A2, SLC6A3, OPRM1, DRD2
166-hydroxydopamine4410.4DRD2, SLC6A3, DBH, OPRM1, DRD3, PDYN
17pramipexole44 49 28 1113.4SLC6A3, DRD3, DRD2, SLC18A2
18tropane4410.4SLC6A4, SLC6A3, SLC18A2
19clonidine44 28 1112.4DBH, SLC6A4, POMC, OPRM1, OPRK1
20methadone44 49 1112.4POMC, ANKK1, OPRM1, OPRK1, DRD2, PDYN
21gbr 129094410.4SLC18A2, SLC6A4, SLC6A3
22tyramine44 28 2412.4DBH, SLC6A4, SLC6A3, OPRM1
23imipramine44 49 28 11 2414.4DBH, SLC6A3, SLC6A4, SLC18A2, DRD3
24mptp4410.4SLC18A2, SLC6A4, SLC6A3, DBH, DRD3, DRD2
25bupropion44 49 11 2413.4ANKK1, SLC18A2, SLC6A4, DRD2, SLC6A3, DRD3
26methamphetamine44 49 1112.3SLC6A4, SLC18A2, OPRM1, SLC6A3, DRD3, DRD2
27haloperidol44 28 2 49 1114.3SLC6A3, DRD3, OPRM1, POMC, SLC18A2, SLC6A4
28morphine44 49 28 1113.3DRD2, DBH, SLC6A3, OPRK1, NPY5R, PDYN
29bibp 3226 trifluoroacetate5910.3NPY1R, NPY2R, NPY5R
30heroin44 49 1112.3PDYN, DRD2, DRD3, OPRK1, OPRM1, POMC
315-hydroxytryptamine4410.2SLC18A2, SLC6A4, DRD2, OPRM1, POMC, DBH
32epinephrine44 11 2412.2DRD2, PDYN, SLC18A2, SLC6A4, DBH, POMC
33levodopa44 1111.2SLC6A3, SLC18A2, DBH, PDYN, OPRK1, OPRM1
34amphetamine44 1111.2DRD2, CARTPT, PDYN, OPRK1, POMC, SLC6A3
35[leu31,pro34]-neuropeptide y (human, rat)5910.2NPY1R, NPY5R, NPY2R
36clozapine44 28 49 1113.2SLC6A3, DRD3, OPRK1, ANKK1, POMC, SLC6A4
37amine4410.2DRD3, SLC18A2, SLC6A4, DBH, OPRK1
38opiate4410.2PDYN, DRD2, OPRK1, OPRM1, POMC, DBH
39neuropeptide y (human, rat)5910.2NPY1R, NPY2R, NPY5R
40biie 02465910.2NPY5R, NPY2R, NPY1R
41ethanol44 49 11 2413.1PDYN, NPY5R, OPRK1, SLC18A2, OPRM1, ANKK1
42nalmefene44 2811.1OPRM1, OPRK1, PDYN
43gaba4410.1DRD2, OPRK1, OPRM1, POMC, DBH, SLC6A3
44acetylcholine44 49 28 11 2414.1NPY5R, DRD2, POMC, OPRM1, OPRK1, DBH
45nicotine44 49 28 1113.0PDYN, DRD2, SLC18A2, SLC6A3, DBH, OPRK1
46glutamate4410.0OPRK1, DBH, SLC6A3, SLC6A4, OPRM1, PDYN
47cocaine44 1111.0SLC6A3, PDYN, DRD2, DRD3, OPRK1, OPRM1
48norepinephrine44 11 2412.0DBH, POMC, OPRM1, OPRK1, DRD3, DRD2
49dermorphin449.9OPRK1, PDYN, OPRM1
50dopamine44 28 11 2412.8SLC18A2, CALY, CARTPT, PDYN, SLC6A4, SLC6A3

GO Terms for genes affiliated with Cocaine Dependence

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16Gene Ontology
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Cellular components related to Cocaine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2integral to plasma membraneGO:0058879.3SLC18A2, CALY, NPY1R, NPY2R, NPY5R, DRD2
3plasma membraneGO:0058869.0DRD2, NPY5R, NPY2R, NPY1R, PDYN, DRD3

Biological processes related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
2response to histamineGO:03477610.7DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
4dopamine catabolic processGO:04242010.7SLC6A3, DBH
5regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3
7adenohypophysis developmentGO:02198410.6SLC6A3, DRD2
8prepulse inhibitionGO:06013410.6DRD2, DRD3, SLC6A3
9reduction of cytosolic calcium ion concentrationGO:05148110.6OPRM1, DRD2
10dopamine metabolic processGO:04241710.6DRD2, DRD3
11behavioral response to ethanolGO:04814910.6DBH, OPRM1, DRD2
12negative regulation of adenylate cyclase activityGO:00719410.6OPRM1, DRD3, DRD2
13regulation of dopamine secretionGO:01405910.6DRD2, DRD3
14visual learningGO:00854210.6DRD2, DRD3, DBH
15monoamine transportGO:01584410.6SLC18A2, SLC6A4, SLC6A3
16sensory perceptionGO:00760010.6OPRK1, OPRM1
17negative regulation of protein secretionGO:05070910.6DRD2, DRD3
18adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.6DRD3, OPRM1
19cardiac left ventricle morphogenesisGO:00321410.6NPY2R, NPY5R
20behavioral response to cocaineGO:04814810.5DRD2, DRD3
21response to cocaineGO:04222010.5SLC18A2, SLC6A3, DRD3, DRD2
22sensory perception of painGO:01923310.5NPY1R, OPRK1, OPRM1
23response to amphetamineGO:00197510.5DRD2, DRD3, DBH, SLC18A2
24circadian regulation of gene expressionGO:03292210.5CARTPT, DRD2, DRD3, PER1
25outflow tract morphogenesisGO:00315110.5NPY1R, NPY2R, NPY5R
26response to iron ionGO:01003910.5DRD2, SLC6A3
27G-protein coupled receptor internalizationGO:00203110.5DRD2, DRD3
28adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.5NPY1R, NPY2R, OPRK1, OPRM1
29synaptic transmission, dopaminergicGO:00196310.5DRD2, DRD3
30response to light stimulusGO:00941610.4PER1, DRD2
31response to drugGO:04249310.3DRD2, DRD3, SLC6A3, SLC6A4
32positive regulation of renal sodium excretionGO:03581510.2DRD3, DRD2
33synaptic transmissionGO:00726810.2CARTPT, PDYN, GABRA2, OPRK1, DBH, SLC6A3
34neuropeptide signaling pathwayGO:00721810.2CARTPT, PDYN, POMC
35neurotransmitter transportGO:00683610.2CPLX4, GABRA2
36locomotory behaviorGO:00762610.1SLC18A2, NPY1R, NPY2R, DRD2, DRD3, OPRK1
37arachidonic acid secretionGO:05048210.0DRD3, DRD2

Molecular functions related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.3SLC6A3, SLC6A4, SLC18A2
2peptide YY receptor activityGO:00160110.3NPY5R, NPY2R, NPY1R
3dopamine bindingGO:03524010.3DRD2, DRD3, SLC6A3
4neuropeptide Y receptor activityGO:00498310.3NPY5R, NPY2R, NPY1R
5pancreatic polypeptide receptor activityGO:00160210.3NPY5R, NPY1R
6serotonin transmembrane transporter activityGO:01522210.2SLC6A4, SLC18A2
7drug bindingGO:00814410.1SLC18A2, SLC6A3, DRD3, DRD2
8dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD3, DRD2

Products for genes affiliated with Cocaine Dependence

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Sources for Cocaine Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet