MCID: CCN001
MIFTS: 52

Cocaine Dependence

Categories: Mental diseases

Aliases & Classifications for Cocaine Dependence

Summaries for Cocaine Dependence

Disease Ontology : 12 A drug dependence that is a psychological dependency on the regular use of cocaine.

MalaCards based summary : Cocaine Dependence is related to psychotic disorder and antisocial personality disorder. An important gene associated with Cocaine Dependence is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Transmission across Chemical Synapses. The drugs Ethanol and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Cocaine dependence is a psychological desire to use cocaine regularly. Cocaine overdose may result in... more...

Related Diseases for Cocaine Dependence

Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 psychotic disorder 31.0 DRD2 DRD3 SLC6A3 SLC6A4
2 antisocial personality disorder 30.5 DRD2 SLC6A3 SLC6A4
3 personality disorder 30.4 DRD2 DRD3 SLC6A3 SLC6A4
4 pathological gambling 30.0 DRD2 DRD3 SLC6A3 SLC6A4
5 bipolar disorder 29.8 DBH DRD2 DRD3 SLC6A3 SLC6A4
6 alcohol abuse 29.8 DRD2 DRD3 SLC6A4
7 schizoaffective disorder 29.8 DRD2 DRD3 SLC6A4
8 schizophrenia 29.7 DBH DRD2 DRD3 SLC6A3 SLC6A4
9 cocaine abuse 29.7 DBH DRD2 SLC6A3 SLC6A4
10 attention deficit-hyperactivity disorder 29.7 DBH DRD2 DRD3 SLC6A3 SLC6A4
11 alexithymia 29.7 DRD2 SLC6A4
12 mood disorder 29.6 DRD2 POMC SLC6A4
13 cannabis abuse 29.3 CHRNA3 CHRNB3
14 smoking as a quantitative trait locus 3 29.2 CHRNA3 CHRNA5
15 major depressive disorder 29.1 DRD2 DRD3 POMC SLC6A3 SLC6A4
16 opioid addiction 29.0 DRD2 OPRD1 OPRK1 OPRM1
17 heroin dependence 28.8 DRD2 OPRD1 OPRM1 PDYN SLC6A3
18 tobacco addiction 27.6 CHRNA3 CHRNA5 CHRNB3 DRD2 OPRM1 SLC6A3
19 alcohol dependence 27.4 DBH DRD2 DRD3 OPRD1 OPRK1 OPRM1
20 drug dependence 26.9 CHRNB3 DRD2 DRD3 OPRD1 OPRK1 OPRM1
21 substance dependence 26.1 CHRNA3 CHRNA5 DRD2 DRD3 OPRD1 OPRK1
22 cocaine intoxication 11.0
23 alcohol use disorder 10.5 DRD2 SLC6A4
24 polysubstance abuse 10.4 DRD2 DRD3
25 delusional disorder 10.4 DRD2 DRD3
26 tardive dyskinesia 10.4 DRD2 DRD3
27 obsessive-compulsive personality disorder 10.4 DRD3 SLC6A4
28 impulse control disorder 10.4 DRD2 DRD3
29 social phobia 10.4 DRD2 SLC6A4
30 striatonigral degeneration 10.4 DRD2 SLC6A3
31 periodic limb movement disorder 10.4 DRD2 SLC6A4
32 bruxism 10.3 DRD2 SLC6A4
33 alcohol-induced mental disorder 10.3 DRD2 SLC6A3 SLC6A4
34 alcoholic psychosis 10.3 DRD2 SLC6A3 SLC6A4
35 premature ejaculation 10.3 SLC6A3 SLC6A4
36 movement disease 10.3 DRD2 DRD3 SLC6A3
37 cutaneous solitary mastocytoma 10.3 PDYN POMC
38 migraine without aura 10.3 DRD2 DRD3 SLC6A4
39 restless legs syndrome 10.3 DRD2 DRD3 SLC6A3
40 stuttering 10.2 DBH DRD2 SLC6A3
41 multiple system atrophy 1 10.2 DBH DRD2 SLC6A3
42 phobic disorder 10.2 OPRK1 SLC6A4
43 functioning pituitary adenoma 10.2 DRD2 POMC
44 gilles de la tourette syndrome 10.2 DBH DRD2 SLC6A3
45 opioid abuse 10.2 DRD2 OPRM1 PDYN
46 retrograde amnesia 10.2 PDYN POMC SLC6A4
47 brunner syndrome 10.2 DBH SLC6A4
48 tic disorder 10.1 DRD2 SLC6A3
49 obsessive-compulsive disorder 10.1 DRD2 DRD3 SLC6A3 SLC6A4
50 withdrawal disorder 10.1 OPRM1 PDYN POMC

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to Cocaine Dependence

Symptoms & Phenotypes for Cocaine Dependence

MGI Mouse Phenotypes related to Cocaine Dependence:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 POMC SLC6A3 SLC6A4 CHRNA3 OPRD1 CHRNA5
2 homeostasis/metabolism MP:0005376 10 POMC SLC6A3 SLC6A4 PDYN DRD3 CHRNA3
3 growth/size/body region MP:0005378 9.97 POMC SLC6A3 SLC6A4 PDYN DRD3 CHRNA3
4 adipose tissue MP:0005375 9.93 POMC PDYN DRD3 DBH OPRM1 DRD2
5 endocrine/exocrine gland MP:0005379 9.91 POMC SLC6A3 SLC6A4 OPRK1 DBH OPRM1
6 digestive/alimentary MP:0005381 9.88 PDYN DRD3 CHRNA3 OPRK1 OPRM1 DRD2
7 integument MP:0010771 9.81 POMC SLC6A3 SLC6A4 OPRD1 OPRK1 DBH
8 nervous system MP:0003631 9.73 POMC SLC6A3 SLC6A4 DRD3 CHRNA3 OPRD1
9 no phenotypic analysis MP:0003012 9.1 POMC PDYN CHRNA3 OPRD1 OPRM1 DRD2

Drugs & Therapeutics for Cocaine Dependence

Drugs for Cocaine Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 325)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-36-2 446220 5760
4
Risperidone Approved, Investigational Phase 4,Phase 2,Phase 1 106266-06-2 5073
5
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
6
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
7
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
8
Biperiden Approved, Investigational Phase 4,Phase 3,Phase 2 514-65-8 2381
9
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
10
Lamotrigine Approved, Investigational Phase 4,Phase 2 84057-84-1 3878
11
Carbamazepine Approved, Investigational Phase 4,Phase 2 298-46-4 2554
12
Amphetamine Approved, Illicit, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 300-62-9 3007 5826
13
Disulfiram Approved Phase 4,Phase 2,Phase 1 97-77-8 3117
14
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
15
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 616-91-1 12035
16
Azacitidine Approved, Investigational Phase 4 320-67-2 9444
17
Caffeine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-08-2 2519
18
Choline Approved, Nutraceutical Phase 4,Phase 3 62-49-7 305
19
Glutamic Acid Approved, Nutraceutical Phase 4,Phase 1,Early Phase 1 56-86-0 33032
20
Serotonin Phase 4,Phase 2,Phase 3,Phase 1 50-67-9 5202
21 Dopamine agonists Phase 4,Phase 2,Phase 3,Phase 1
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
24 Central Nervous System Stimulants Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
25 Serotonin Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Serotonin Antagonists Phase 4,Phase 2,Phase 1
27 Muscarinic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
28 Sodium Channel Blockers Phase 4,Phase 2,Phase 1
29 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Cholinergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
31 Gastrointestinal Agents Phase 4,Phase 2,Phase 1
32 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Tranquilizing Agents Phase 4,Phase 2,Phase 1,Early Phase 1
34 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3,Phase 2,Phase 1
36 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Dermatologic Agents Phase 4,Phase 2
39 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Parasympatholytics Phase 4,Phase 3,Phase 2,Phase 1
41 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 1
42 Wakefulness-Promoting Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Anti-Anxiety Agents Phase 4,Phase 2,Phase 1
45 Dopamine Antagonists Phase 4,Phase 2,Phase 1,Early Phase 1
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1
48 Dopamine Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
50 Antiemetics Phase 4,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 334)

# Name Status NCT ID Phase Drugs
1 Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence Unknown status NCT00495183 Phase 4 caffeine;Biperiden;Placebo
2 Pharmacologic MRI in Cocaine Addiction Unknown status NCT01652378 Phase 4 ondansetron, lidocaine
3 Citicoline for Bipolar 1 Disorder and Cocaine Dependence Completed NCT00619723 Phase 4 Citicoline;Placebo
4 An Add-On Trial of Quetiapine in Patients With Bipolar Disorder and Cocaine Dependence Completed NCT00223210 Phase 4 Quetiapine;PLacebo
5 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed NCT00280293 Phase 4 Lamotrigine;Placebo
6 Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction Completed NCT02626494 Phase 4 N-Acetylcystein;Placebo
7 Pathophysiological Subtyping of Abnormalities in Cocaine Dependence - 9 Completed NCT00015275 Phase 4
8 Quetiapine for Cocaine Use and Cravings Completed NCT00232336 Phase 4 quetiapine
9 Pharmacotherapy and Intensive Treatment - 2 Completed NCT00000218 Phase 4 Carbamazepine
10 Effects of Modafinil in Methamphetamine Dependence Completed NCT00751023 Phase 4 Modafinil;Placebo
11 Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia Completed NCT00208143 Phase 4 Quetiapine;Risperidone
12 The Maternal Lifestyle Study (MLS) Completed NCT00059540 Phase 4
13 Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial. Recruiting NCT03018236 Phase 4 Alcohol N-acetylcysteine;Alcohol Placebo;Cocaine N-acetylcysteine;Cocaine Placebo
14 A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts Withdrawn NCT02134002 Phase 4 Disulfiram;Placebo
15 Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1 Unknown status NCT00249691 Phase 3 Topiramate + Cognitive Behavioral Therapy;Placebo + Cognitive Behavioral Therapy
16 Novel Pharmacotherapy for Dual Dependence Unknown status NCT00448825 Phase 3 Topiramate + Cognitive Behavioral Therapy;Placebo + Cognitive Behavioral Therapy
17 Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence Completed NCT01811940 Phase 2, Phase 3 Adderall-ER;Topiramate
18 Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence Completed NCT01468012 Phase 2, Phase 3 levodopa carbidopa and entacapone (LCE);Placebo
19 Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence Completed NCT00553319 Phase 2, Phase 3 Placebo;Adderall-XR;Adderall-XR
20 Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1 Completed NCT00032929 Phase 3 Selegiline
21 Brain Imaging Study of the Effects of Modafinil in Cocaine Addiction Completed NCT00701532 Phase 3 Modafinil and PET (brain imaging);placebo
22 Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence Completed NCT00167232 Phase 3 Naltrexone
23 Dose Response Trial of Pergolide for Cocaine Dependence - 1 Completed NCT00000248 Phase 3 Pergolide
24 Investigation of Mifepristone (RU486) on Stress Sensitivity and Relapse Prevention in Cocaine Dependent Patients Completed NCT01134198 Phase 2, Phase 3 Mifepristone;placebo
25 Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1 Completed NCT00218660 Phase 3 Naltrexone;Placebo
26 Vigabatrin for the Treatment of Cocaine Dependency Completed NCT01281202 Phase 2, Phase 3 Vigabatrin;Matching Placebo
27 Adaptive Treatment for Alcohol and Cocaine Dependence Completed NCT01032135 Phase 2, Phase 3 medication management
28 Cocaine Use Reduction With Buprenorphine Completed NCT01402492 Phase 2, Phase 3 Buprenorphine + Naltrexone;Placebo + Naltrexone
29 Cocaine/Crack and Reduction of Compulsion With Biperiden Completed NCT01251393 Phase 3 Biperiden;Placebo
30 Clinical Neurobiology of Serotonin and Addiction Completed NCT00732901 Phase 2, Phase 3 Escitalopram;Placebo
31 Progesterone Treatment for Cocaine-dependent Women: A Pilot Study Completed NCT00632099 Phase 2, Phase 3 Oral micronized progesterone;Placebo
32 Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients Completed NCT00495092 Phase 2, Phase 3 Caffeine;Biperiden;Placebo
33 Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10 Completed NCT00000293 Phase 3 Nefazodone
34 Smoking-Cessation and Stimulant Treatment (S-CAST) Completed NCT01077024 Phase 3
35 Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1 Completed NCT00061087 Phase 2, Phase 3 Methylphenidate;Bupropion
36 Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence Completed NCT00223236 Phase 3 Citicoline;Placebo
37 Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence Recruiting NCT02111798 Phase 2, Phase 3 Bupropion XL;placebo
38 Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients. Active, not recruiting NCT02255357 Phase 2, Phase 3 Placebo;Intranasal Oxytocin
39 Change the Cycle: An RCT to Prevent Injection Initiation Active, not recruiting NCT02774954 Phase 3
40 Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence Unknown status NCT00123383 Phase 2 Modafinil
41 Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence Unknown status NCT01397266 Phase 2
42 A Double-Blind, Controlled Study of Aripiprazole in Co-Morbid Schizophrenia and Cocaine Dependence Unknown status NCT00737256 Phase 2 Aripiprazole;Perphenazine
43 A Pilot Study of Candesartan as a Treatment for Cocaine Dependence Unknown status NCT01938664 Phase 2 Candesartan;Placebo
44 Treating Cocaine Abuse: A Behavioral Approach Unknown status NCT01822327 Phase 2
45 Effects of Repeated Transcranial Magnetic Stimulation (rTMS) on the Treatment of Cocaine Addicted Patients Unknown status NCT01259362 Phase 2
46 Repetitive Transcranial Magnetic Stimulation in Symptoms of Attention Deficit Hyperactivity Disorder and Cognitive Function In Cocaine Addicts Unknown status NCT01593982 Phase 2
47 Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving Unknown status NCT01929343 Phase 2 lidocaine following cue-induced craving;lidocaine following neutral stimulus;saline
48 Psychopharmacology for Cocaine Dependence - Buspirone Completed NCT01267292 Phase 2 Buspirone;Placebo for Buspirone;Methylphenidate;Placebo for Methylphenidate
49 Brain Function and Structure in Cocaine Dependence Completed NCT02080832 Phase 2 Citalopram;Placebo
50 Pharmacogenetics of Doxazosin for Cocaine Dependence Completed NCT01145183 Phase 2 Doxazosin;Placebo

Search NIH Clinical Center for Cocaine Dependence

Genetic Tests for Cocaine Dependence

Anatomical Context for Cocaine Dependence

MalaCards organs/tissues related to Cocaine Dependence:

38
Brain, Heart, Cortex, Prefrontal Cortex, Pituitary, Testes, Prostate

Publications for Cocaine Dependence

Articles related to Cocaine Dependence:

(show top 50) (show all 617)
# Title Authors Year
1
Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial. ( 29258028 )
2018
2
Attentional bias toward alcohol stimuli as a predictor of treatment retention in cocaine dependence and alcohol user patients. ( 29136565 )
2018
3
Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence. ( 29422497 )
2018
4
Neurostimulation techniques in the treatment of cocaine dependence: A review of the literature. ( 28822321 )
2018
5
Cocaine dependence modulates the effect of HIV infection on brain activation during intertemporal decision making. ( 28711810 )
2017
6
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. ( 29286595 )
2017
7
Kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms? ( 27885412 )
2017
8
Functional neural changes following behavioral therapies and disulfiram for cocaine dependence. ( 28714728 )
2017
9
Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence. ( 28823835 )
2017
10
Reply to: kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms? ( 27896378 )
2017
11
Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence. ( 28984746 )
2017
12
White Matter Changes in HIV+ Women with a History of Cocaine Dependence. ( 29163330 )
2017
13
Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence. ( 28857070 )
2017
14
A Novel Therapy for cocaine dependence during abstinence: A randomized clinical trial. ( 28894547 )
2017
15
Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. ( 28251596 )
2017
16
Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence. ( 28074533 )
2017
17
Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis. ( 28350194 )
2017
18
A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence. ( 28190084 )
2017
19
A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. ( 27449273 )
2016
20
Efficacy of topiramate in the treatment of crack cocaine dependence: a double-blind, randomized, placebo-controlled trial. ( 27046312 )
2016
21
Crack-cocaine dependence and aging: effects on working memory. ( 27111700 )
2016
22
Psychiatric comorbidity in a sample of cocaine-dependent outpatients seen in the Community of Madrid drug addiction care network. ( 26990385 )
2016
23
Psychostimulant drugs for cocaine dependence. ( 27670244 )
2016
24
Effect of Continuing Care for Cocaine Dependence on HIV Sex-Risk Behaviors. ( 27224980 )
2016
25
Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence. ( 27394932 )
2016
26
Antipsychotic medications for cocaine dependence. ( 26992929 )
2016
27
Effective drug therapy for cocaine dependence: a milestone. ( 27015910 )
2016
28
Cocaine dependence and thalamic functional connectivity: a multivariate pattern analysis. ( 27556009 )
2016
29
Buprenorphinea88+a88Naloxone plus Naltrexone for the Treatment of Cocaine Dependence: The Cocaine Use Reduction with Buprenorphine (CURB) Study. ( 26948856 )
2016
30
Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users. ( 26833821 )
2016
31
Mixed-amphetamine salts increase abstinence from marijuana in patients with co-occurring attention-deficit/hyperactivity disorder and cocaine dependence. ( 28051838 )
2016
32
Psychotic symptoms associated with the use of dopaminergic drugs, in patients with cocaine dependence or abuse. ( 27009114 )
2016
33
Dissociable Effects of Cocaine-Dependence on Reward Processes: The Role of Acute Cocaine and Craving. ( 27545986 )
2016
34
Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases. ( 26792050 )
2016
35
Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users. ( 27499362 )
2016
36
Modafinil and sleep architecture in an inpatient-outpatient treatment study of cocaine dependence. ( 26777774 )
2016
37
Topiramate for Cocaine Dependence: A Systematic Review and Meta-Analysis of Randomized Control Trials. ( 26826006 )
2016
38
Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders: Impulsivity Dimensions as Predictors of Current Cocaine Dependence. ( 27014100 )
2016
39
Assessing the effects of cocaine dependence and pathological gambling using group-wise sparse representation of natural stimulus FMRI data. ( 27704410 )
2016
40
Polysomnographic measures of sleep in cocaine dependence and alcohol dependence: Implications for age-related loss of slow wave, stage 3 sleep. ( 26749502 )
2016
41
A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. ( 27498889 )
2016
42
Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. ( 26792441 )
2016
43
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. ( 26817621 )
2016
44
Successful classification of cocaine dependence using brain imaging: a generalizable machine learning approach. ( 27766943 )
2016
45
Just showing up is not enough: Homework adherence and outcome in cognitive-behavioral therapy for cocaine dependence. ( 27454780 )
2016
46
Attenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences. ( 27441590 )
2016
47
Clinical differences between cocaine-dependent patients with and without antisocial personality disorder. ( 27839828 )
2016
48
WITHDRAWN: Anticonvulsants for cocaine dependence. ( 25731153 )
2015
49
Effect of cocaine dependence on brain connections: clinical implications. ( 26512421 )
2015
50
Increased corticolimbic connectivity in cocaine dependence versus pathological gambling is associated with drug severity and emotion-related impulsivity. ( 25818325 )
2015

Variations for Cocaine Dependence

Expression for Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for Cocaine Dependence

Pathways related to Cocaine Dependence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 CHRNA3 CHRNA5 CHRNB3 DRD2 DRD3 OPRD1
2
Show member pathways
12.57 CHRNA3 CHRNA5 CHRNB3 SLC6A3 SLC6A4
3
Show member pathways
12.43 CHRNA3 DRD2 DRD3 SLC6A3
4
Show member pathways
11.65 DRD2 PDYN SLC6A3
5 11.6 OPRD1 OPRM1 POMC
6
Show member pathways
11.36 CHRNA3 CHRNA5 CHRNB3
7
Show member pathways
11.27 CHRNA3 CHRNA5 DRD2 DRD3
8
Show member pathways
10.97 DBH SLC6A3 SLC6A4
9
Show member pathways
10.89 SLC6A3 SLC6A4
10 10.78 DRD2 DRD3

GO Terms for Cocaine Dependence

Cellular components related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 DRD2 DRD3 OPRD1 OPRK1 OPRM1 SLC6A3
2 synapse GO:0045202 9.83 CHRNA3 CHRNA5 CHRNB3 OPRK1
3 neuronal cell body GO:0043025 9.8 CHRNA3 OPRK1 PDYN SLC6A3
4 membrane raft GO:0045121 9.73 OPRD1 OPRM1 SLC6A3 SLC6A4
5 postsynaptic membrane GO:0045211 9.71 CHRNA3 CHRNA5 CHRNB3 OPRD1
6 perikaryon GO:0043204 9.65 DRD2 OPRK1 OPRM1
7 dendrite GO:0030425 9.65 CHRNA3 DRD2 OPRK1 OPRM1 PDYN
8 neuron projection GO:0043005 9.55 OPRD1 OPRK1 OPRM1 SLC6A3 SLC6A4
9 dendrite membrane GO:0032590 9.51 OPRD1 OPRM1
10 acetylcholine-gated channel complex GO:0005892 9.13 CHRNA3 CHRNA5 CHRNB3
11 axon terminus GO:0043679 8.92 DRD2 OPRD1 OPRK1 PDYN
12 integral component of membrane GO:0016021 10.2 CHRNA3 CHRNA5 CHRNB3 DBH DRD2 DRD3
13 plasma membrane GO:0005886 10.06 CHRNA3 CHRNA5 CHRNB3 DRD2 DRD3 OPRD1

Biological processes related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 DRD2 DRD3 SLC6A3 SLC6A4
2 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.83 OPRD1 OPRK1 OPRM1
3 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.82 OPRD1 OPRK1 OPRM1
4 sensory perception of pain GO:0019233 9.81 OPRD1 OPRK1 OPRM1
5 visual learning GO:0008542 9.8 DBH DRD2 DRD3
6 response to ethanol GO:0045471 9.8 DRD2 DRD3 OPRK1 OPRM1 SLC6A3
7 negative regulation of adenylate cyclase activity GO:0007194 9.77 DRD2 DRD3 OPRM1
8 neuropeptide signaling pathway GO:0007218 9.77 OPRD1 OPRK1 OPRM1 PDYN POMC
9 regulation of sensory perception of pain GO:0051930 9.75 OPRD1 OPRK1 OPRM1
10 response to amphetamine GO:0001975 9.74 DBH DRD2 DRD3
11 eating behavior GO:0042755 9.73 OPRD1 OPRK1 OPRM1
12 response to nicotine GO:0035094 9.73 CHRNA5 CHRNB3 DRD2 SLC6A3
13 chemical synaptic transmission GO:0007268 9.73 CHRNA5 DBH OPRD1 OPRK1 OPRM1 PDYN
14 positive regulation of multicellular organism growth GO:0040018 9.72 DRD2 SLC6A3
15 negative regulation of blood pressure GO:0045776 9.72 DRD2 DRD3
16 neuromuscular synaptic transmission GO:0007274 9.72 CHRNA5 CHRNB3
17 synaptic transmission, cholinergic GO:0007271 9.72 CHRNA3 CHRNA5 CHRNB3
18 associative learning GO:0008306 9.71 DBH DRD2
19 arachidonic acid secretion GO:0050482 9.71 DRD2 DRD3
20 regulation of dopamine secretion GO:0014059 9.71 DRD2 DRD3
21 dopamine receptor signaling pathway GO:0007212 9.71 DRD2 DRD3
22 response to iron ion GO:0010039 9.71 DRD2 SLC6A3
23 behavioral response to cocaine GO:0048148 9.71 DRD2 DRD3 OPRK1
24 synaptic transmission, dopaminergic GO:0001963 9.7 DRD2 DRD3
25 negative regulation of protein secretion GO:0050709 9.7 DRD2 DRD3
26 estrous cycle GO:0044849 9.7 OPRK1 OPRM1
27 dopamine metabolic process GO:0042417 9.7 DRD2 DRD3
28 neurotransmitter biosynthetic process GO:0042136 9.69 SLC6A3 SLC6A4
29 ammonium transmembrane transport GO:0072488 9.69 SLC6A3 SLC6A4
30 positive regulation of renal sodium excretion GO:0035815 9.69 DRD2 DRD3
31 behavioral response to ethanol GO:0048149 9.69 DBH DRD2 OPRM1
32 maternal behavior GO:0042711 9.68 DBH OPRK1
33 G-protein coupled receptor internalization GO:0002031 9.68 DRD2 DRD3
34 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.68 DRD2 DRD3
35 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.67 DRD3 OPRM1
36 adenohypophysis development GO:0021984 9.67 DRD2 SLC6A3
37 monoamine transport GO:0015844 9.67 SLC6A3 SLC6A4
38 sensory perception GO:0007600 9.67 OPRK1 OPRM1 PDYN
39 dopamine catabolic process GO:0042420 9.66 DBH SLC6A3
40 regulation of cAMP metabolic process GO:0030814 9.66 DRD2 DRD3
41 behavioral response to nicotine GO:0035095 9.65 CHRNA3 CHRNA5
42 dopamine uptake involved in synaptic transmission GO:0051583 9.65 SLC6A3 SLC6A4
43 prepulse inhibition GO:0060134 9.65 DRD2 DRD3 SLC6A3
44 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.63 DRD2 DRD3
45 opioid receptor signaling pathway GO:0038003 9.63 OPRD1 OPRK1 OPRM1
46 negative regulation of dopamine receptor signaling pathway GO:0060160 9.62 DRD2 DRD3
47 acid secretion GO:0046717 9.62 DRD2 DRD3
48 response to morphine GO:0043278 9.62 DRD2 DRD3 OPRK1 OPRM1
49 response to histamine GO:0034776 9.61 DRD2 DRD3
50 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.59 OPRK1 OPRM1

Molecular functions related to Cocaine Dependence according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.95 DRD2 DRD3 OPRD1 OPRK1 OPRM1
2 signal transducer activity GO:0004871 9.86 DRD2 DRD3 OPRD1 OPRM1
3 drug binding GO:0008144 9.67 DRD2 DRD3 SLC6A3
4 extracellular ligand-gated ion channel activity GO:0005230 9.61 CHRNA3 CHRNA5 CHRNB3
5 neuropeptide hormone activity GO:0005184 9.57 PDYN POMC
6 neurotransmitter:sodium symporter activity GO:0005328 9.54 SLC6A3 SLC6A4
7 ligand-gated ion channel activity GO:0015276 9.54 CHRNA3 CHRNA5 CHRNB3
8 acetylcholine receptor activity GO:0015464 9.52 CHRNA3 CHRNA5
9 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.51 DRD2 DRD3
10 neuropeptide binding GO:0042923 9.5 OPRD1 OPRK1 OPRM1
11 monoamine transmembrane transporter activity GO:0008504 9.48 SLC6A3 SLC6A4
12 dopamine neurotransmitter receptor activity GO:0004952 9.46 DRD2 DRD3
13 acetylcholine binding GO:0042166 9.43 CHRNA3 CHRNA5 CHRNB3
14 dopamine:sodium symporter activity GO:0005330 9.4 SLC6A3 SLC6A4
15 acetylcholine-gated cation-selective channel activity GO:0022848 9.33 CHRNA3 CHRNA5 CHRNB3
16 dopamine binding GO:0035240 9.13 DRD2 DRD3 SLC6A3
17 opioid receptor activity GO:0004985 8.8 OPRD1 OPRK1 OPRM1

Sources for Cocaine Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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