MCID: CCN001
MIFTS: 54

Cocaine Dependence malady

Summaries for Cocaine Dependence

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Cocaine dependence (or addiction) is a psychological desire to use cocaine regularly. Cocaine overdose... more...

MalaCards: Cocaine Dependence is related to alcohol dependence and heroin dependence. An important gene associated with Cocaine Dependence is PDYN (prodynorphin), and among its related pathways are Dopamine receptors and Monoamine Transport. The compounds u50488 and nmda have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are taste/olfaction and adipose tissue.

Disease Ontology:8 A drug dependence that is a psychological dependency on the regular use of cocaine.

Aliases & Classifications for Cocaine Dependence

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

cocaine dependence 8 10 45 61


External Ids:

Disease Ontology8 DOID:9975
ICD9CM27 304.20, 304.2
NCIt40 C34492
MeSH35 D019970

Related Diseases for Cocaine Dependence

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cocaine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.1DRD2, GABRA2, SLC6A4, ANKK1, OPRM1, OPRK1
2heroin dependence30.8DRD2, ANKK1
3cocaine abuse30.8DRD2, OPRK1, DBH, SLC6A3, SLC6A4
4antisocial personality disorder30.7ANKK1, SLC6A3, SLC6A4, DRD2
5bipolar disorder30.6DRD2, SLC6A4
6substance dependence30.5OPRM1, SLC6A3, SLC6A4, DRD2, PDYN, DRD3
7nicotine dependence30.5SLC6A4, ANKK1, DRD2
8attention deficit hyperactivity disorder30.4DRD2, DBH, SLC6A4, SLC6A3, SLC18A2
9alexithymia30.0ANKK1
10pathological gambling30.0DRD3, DRD2, SLC6A3
11schizoaffective disorder30.0SLC6A4, DRD2, DRD3
12alcohol abuse30.0SLC6A3, OPRM1, DRD3, DRD2, SLC6A4
13drug addiction30.0SLC18A2, SLC6A3, OPRM1, OPRK1, DRD3, DRD2
14cannabis dependence10.5
15dependent personality disorder10.4
16post-traumatic stress disorder10.3
17major depressive disorder10.0
18borderline personality disorder10.0
19cannabis abuse10.0
20n syndrome10.0
21brain disease10.0
22syphilis10.0
23restless legs syndrome10.0DRD2
24bulimia nervosa10.0SLC6A4
25eating disorder10.0SLC6A4
26prion disease10.0POMC
27opiate dependence10.0OPRM1
28neuroleptic malignant syndrome10.0DRD2
29fibromyalgia10.0SLC6A4
30anorexia nervosa10.0SLC6A4, POMC
31neuroblastoma10.0DBH, OPRM1
32obsessive-compulsive personality disorder10.0SLC6A4
33delusional disorder10.0DRD2
34alcoholic psychosis10.0SLC6A4
35essential hypertension10.0DBH
36wilson disease10.0SLC6A3, DRD2
37anxiety disorder10.0SLC6A4
38constipation10.0OPRM1, SLC6A4
39gilles de la tourette syndrome10.0SLC6A3, DRD2
40chronic fatigue syndrome10.0POMC, SLC6A4
41dementia10.0OPRM1, OPRK1, SLC6A3
42hypertension10.0SLC6A4, POMC, DBH
43endogenous depression10.0SLC6A4, DRD3
44amnestic disorder10.0OPRK1, OPRM1, PDYN
45multiple system atrophy10.0SLC6A3, DRD2, DBH
46melancholia10.0POMC
47papillon-lefevre disease10.0NPY5R
48cholera10.0SLC6A4, POMC
49social phobia10.0SLC6A4, DRD2
50myoclonus-dystonia10.0DRD2

Graphical network of the top 20 diseases related to Cocaine Dependence:



Diseases related to cocaine dependence

Clinical Features for Cocaine Dependence

Drugs & Therapeutics for Cocaine Dependence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cocaine Dependence

Drug clinical trials:

Search ClinicalTrials for Cocaine Dependence

Search NIH Clinical Center for Cocaine Dependence

Search CenterWatch for Cocaine Dependence

Genetic Tests for Cocaine Dependence

Anatomical Context for Cocaine Dependence

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cocaine Dependence:

33
Brain, Cortex, Heart, Prostate, Monocytes, Temporal lobe, Adrenal cortex, Pituitary

Animal Models for Cocaine Dependence or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cocaine Dependence

Sources:
51PubMed
See all sources

Articles related to Cocaine Dependence:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Individual Differences in Attentional Bias Associated with Cocaine Dependence Are Related to Varying Engagement of Neural Processing Networks. (24196947)
2013
2
Negative urgency, disinhibition and reduced temporal pole gray matter characterize the comorbidity of cocaine dependence and personality disorders. (23466222)
2013
3
Sex differences in decreased limbic and cortical grey matter volume in cocaine dependence: a voxel-based morphometric study. (23167305)
2013
4
Could disulfiram be a new treatment for crack cocaine dependence?: a pilot study. (23567610)
2013
5
Executive cognitive dysfunction and ADHD in cocaine dependence: searching for a common cognitive endophenotype for addictive disorders. (24155725)
2013
6
Association study of the I^-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. (22472784)
2012
7
Efficacy of contingency management for cocaine dependence treatment: a review of the evidence. (23244344)
2012
8
Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (21426264)
2012
9
Adding voucher-based incentives to community reinforcement approach improves outcomes during treatment for cocaine dependence. (21838845)
2011
10
Acoustic startle reduction in cocaine dependence persists for 1 year of abstinence. (21161186)
2011
11
Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route. (19595517)
2009
12
Brain macrostructural and microstructural abnormalities in cocaine dependence. (17904770)
2008
13
Bupropion hydrochloride versus placebo, in combination with cognitive behavioral therapy, for the treatment of cocaine abuse/dependence. (18551884)
2008
14
The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (18422838)
2008
15
New treatments for cocaine dependence: a focused review. (17927843)
2008
16
Efficacy of central nervous system stimulant treatment for cocaine dependence: a systematic review and meta-analysis of randomized controlled clinical trials. (18031423)
2007
17
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. (17403976)
2007
18
Safety, tolerability and efficacy of levodopa-carbidopa treatment for cocaine dependence: two double-blind, randomized, clinical trials. (17134849)
2007
19
Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. (17106427)
2006
20
Pills for speedballing or cocaine dependence. (16731254)
2006
21
Prize reinforcement contingency management for cocaine dependence: integration with group therapy in a methadone clinic. (15796645)
2005
22
A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence. (15730350)
2005
23
Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (16314758)
2005
24
Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol. (14766440)
2004
25
A pilot trial of piracetam and ginkgo biloba for the treatment of cocaine dependence. (12628617)
2003
26
Dopamine transporter as target for drug development of cocaine dependence medications. (14612141)
2003
27
Pharmacologic treatments for heroin and cocaine dependence. (12857659)
2003
28
A national 5-year follow-up of treatment outcomes for cocaine dependence. (12044196)
2002
29
Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence. (12095075)
2002
30
Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder. (12233988)
2002
31
Gabapentin in the treatment of cocaine dependence: a case series. (11235923)
2001
32
Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. (11900612)
2001
33
Cocaine withdrawal symptoms and initial urine toxicology results predict treatment attrition in outpatient cocaine dependence treatment. (11255939)
2001
34
Pharmacotherapies for cocaine dependence. (11123003)
2000
35
Carbamazepine for cocaine dependence. (10796844)
2000
36
Coping and social skills training for alcohol and cocaine dependence. (10385943)
1999
37
Psychosocial treatments for cocaine dependence: National Institute on Drug Abuse Collaborative Cocaine Treatment Study. (10359461)
1999
38
Cocaine abuse and dependence linked to genetic risk factors among female twins. (18751166)
1999
39
Increasing treatment adherence among outpatients with depression and cocaine dependence: results of a pilot study. (9812129)
1998
40
Pharmacotherapy of cerebral ischemia in cocaine dependence. (9543650)
1998
41
Management of cocaine abuse and dependence. (8596599)
1996
42
Day versus inpatient treatment for cocaine dependence: an experimental comparison. (10172622)
1996
43
Pharmacological approaches to cocaine dependence. (1498999)
1992
44
Developing and evaluating new treatments for alcoholism and cocaine dependence. (1589603)
1992
45
Buprenorphine for cocaine and opiate dependence. (1609037)
1992
46
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. (2701321)
1989
47
Pharmacologic treatment of cocaine dependence. (18750646)
1989
48
Outcomes of cocaine-dependence treatment. (2640977)
1989
49
The diagnosis of alcohol, cocaine, and other drug dependence in an inpatient treatment population. (2709471)
1989
50
Cocaine dependence. (2658744)
1989

Genetic Variations for Cocaine Dependence

Expression for genes affiliated with Cocaine Dependence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cocaine Dependence

Search GEO for disease gene expression data for Cocaine Dependence.

Pathways for genes affiliated with Cocaine Dependence

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DRD3, DRD2
210.2SLC6A4, DBH, SLC6A3
3
Hide members
10.2DRD2, DRD3, SLC18A2
410.2PDYN, CARTPT, PER1
5
Hide members
10.1SLC18A2, SLC6A4, CPLX4
6
Hide members
10.1SLC18A2, SLC6A3, DRD2, PDYN
710.1PDYN, DRD2, SLC6A3, SLC18A2
8
Hide members
10.1SLC6A4, DRD3, DRD2, SLC18A2
9
Hide members
10.1DBH, SLC18A2, NPY2R, NPY1R
10
Hide members
10.0NPY1R, OPRK1, NPY5R, NPY2R, OPRM1
11
Hide members
9.7NPY5R, PDYN, NPY1R, NPY2R, POMC, OPRM1
12
Hide members
9.6OPRM1, CALY, DRD2, DRD3, GABRA2, PER1
13
Hide members
9.5POMC, OPRM1, OPRK1, GABRA2, PDYN, NPY1R

Compounds for genes affiliated with Cocaine Dependence

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Cocaine Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 253)
idCompoundScoreTop Affiliating Genes
1u5048845 2911.5PDYN, OPRM1, OPRK1
2nmda45 2911.5OPRK1, OPRM1, SLC6A3, PDYN
3sulpiride45 29 1112.5PDYN, DRD3, DRD2, SLC6A3
4piperazine45 1111.5OPRM1, DRD2, DRD3, SLC6A3
5duloxetine45 50 29 1113.5SLC6A3, SLC6A4, SLC18A2, DRD3
6etorphine45 29 1112.5OPRK1, OPRM1, POMC, PDYN
72beta-carbomethoxy-3beta-(4-iodophenyl)tropane4510.5SLC6A3, SLC6A4, SLC18A2
8methylphenidate45 50 1112.5DRD2, SLC6A4, SLC18A2, SLC6A3
9maoa4510.5DBH, SLC6A4, SLC6A3, POMC, DRD2
10[leu31,pro34]pyy (human)2910.5NPY5R, NPY2R, NPY1R
11[ala31,aib32]npy (pig)2910.4NPY1R, NPY5R, NPY2R
12quinpirole45 2911.4DRD2, PDYN, SLC6A3, DRD3
13risperidone29 45 50 60 11 2415.4SLC6A3, ANKK1, DRD3, DRD2, SLC6A4
14tropane4510.4SLC18A2, SLC6A3, SLC6A4
15ketamine45 29 1112.4OPRM1, DRD2, SLC18A2, SLC6A3, SLC6A4
166-hydroxydopamine4510.4DBH, SLC6A3, OPRM1, PDYN, DRD2, DRD3
17pramipexole45 50 29 1113.4DRD3, SLC6A3, SLC18A2, DRD2
18nisoxetine45 2911.4SLC18A2, SLC6A4, SLC6A3
19clonidine45 29 1112.4POMC, OPRM1, OPRK1, SLC6A4, DBH
20methadone45 50 1112.4POMC, ANKK1, OPRM1, OPRK1, DRD2, PDYN
21gbr 129094510.4SLC18A2, SLC6A3, SLC6A4
22tyramine45 29 2412.4DBH, SLC6A3, SLC6A4, OPRM1
23imipramine45 50 29 11 2414.4DRD3, SLC18A2, SLC6A4, SLC6A3, DBH
24mptp4510.4DBH, DRD3, DRD2, SLC6A4, SLC6A3, SLC18A2
25bupropion45 50 11 2413.4ANKK1, SLC18A2, SLC6A4, DRD2, SLC6A3, DRD3
26methamphetamine45 50 1112.3SLC6A4, SLC18A2, OPRM1, SLC6A3, DRD3, DRD2
27haloperidol45 29 2 50 1114.3SLC6A3, DRD3, OPRM1, POMC, SLC18A2, SLC6A4
28morphine45 50 29 1113.3DRD2, PDYN, NPY5R, OPRK1, OPRM1, DBH
29bibp 3226 trifluoroacetate6010.3NPY1R, NPY2R, NPY5R
30heroin45 50 1112.3PDYN, DRD2, DRD3, OPRK1, OPRM1, POMC
315-hydroxytryptamine4510.2SLC6A3, DRD2, OPRM1, DBH, POMC, SLC18A2
32epinephrine45 11 2412.2DRD2, OPRM1, POMC, PDYN, DBH, SLC6A4
33levodopa45 1111.2SLC6A3, SLC18A2, DBH, PDYN, OPRK1, OPRM1
34nalmefene45 2911.2PDYN, OPRM1, OPRK1
35amphetamine45 1111.2DRD2, CARTPT, PDYN, OPRK1, POMC, SLC6A3
36bibo 3304 trifluoroacetate6010.2NPY5R, NPY2R, NPY1R
37lobeline4510.2SLC18A2, SLC6A4, SLC6A3
38clozapine45 29 50 1113.2SLC6A3, DRD3, OPRK1, ANKK1, POMC, SLC6A4
39amine4510.2SLC18A2, DRD3, SLC6A4, DBH, OPRK1
40opiate4510.2PDYN, DRD2, OPRK1, OPRM1, POMC, DBH
41ethanol45 50 11 2413.1NPY5R, DBH, PDYN, SLC18A2, ANKK1, OPRK1
42gaba4510.1DRD2, OPRK1, OPRM1, POMC, DBH, SLC6A3
43acetylcholine45 50 29 11 2414.1NPY5R, DRD2, POMC, OPRM1, OPRK1, DBH
44[leu31,pro34]-neuropeptide y (human, rat)6010.1NPY1R, NPY5R, NPY2R
45nicotine45 50 29 1113.0PDYN, DRD2, SLC18A2, SLC6A3, DBH, OPRK1
46glutamate4510.0SLC18A2, OPRK1, OPRM1, DBH, PDYN, DRD2
47cocaine45 1111.0SLC6A3, PDYN, DRD2, DRD3, OPRK1, OPRM1
48norepinephrine45 11 2412.0DBH, POMC, OPRM1, OPRK1, DRD3, DRD2
49alpha-methyl-p-tyrosine459.9DRD2, DBH, SLC6A3
50dopamine45 29 11 2412.8SLC18A2, CALY, CARTPT, PDYN, SLC6A4, SLC6A3

GO Terms for genes affiliated with Cocaine Dependence

Sources:
16Gene Ontology
See all sources

Cellular components related to Cocaine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3DBH, POMC
2integral to plasma membraneGO:0058879.3SLC18A2, SLC6A4, SLC6A3, OPRM1, OPRK1, DRD3
3plasma membraneGO:0058869.0SLC18A2, PDYN, SLC6A4, SLC6A3, OPRM1, OPRK1

Biological processes related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD3, DRD2
2negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD2, DRD3
4dopamine catabolic processGO:04242010.7DBH, SLC6A3
5regulation of cAMP metabolic processGO:03081410.7DRD3, DRD2
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD3, DRD2
7adenohypophysis developmentGO:02198410.6SLC6A3, DRD2
8prepulse inhibitionGO:06013410.6DRD2, SLC6A3, DRD3
9reduction of cytosolic calcium ion concentrationGO:05148110.6DRD2, OPRM1
10dopamine metabolic processGO:04241710.6DRD2, DRD3
11behavioral response to ethanolGO:04814910.6DRD2, DBH, OPRM1
12negative regulation of adenylate cyclase activityGO:00719410.6DRD2, OPRM1, DRD3
13visual learningGO:00854210.6DRD3, DRD2, DBH
14monoamine transportGO:01584410.6SLC18A2, SLC6A3, SLC6A4
15adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.6OPRM1, DRD3
16regulation of dopamine secretionGO:01405910.6DRD2, DRD3
17sensory perceptionGO:00760010.6OPRM1, OPRK1
18synaptic transmission, dopaminergicGO:00196310.6DRD3, DRD2
19cardiac left ventricle morphogenesisGO:00321410.6NPY2R, NPY5R
20negative regulation of protein secretionGO:05070910.5DRD2, DRD3
21response to cocaineGO:04222010.5SLC6A3, DRD2, SLC18A2, DRD3
22sensory perception of painGO:01923310.5OPRM1, OPRK1, NPY1R
23response to amphetamineGO:00197510.5DRD2, SLC18A2, DBH, DRD3
24circadian regulation of gene expressionGO:03292210.5CARTPT, DRD2, PER1, DRD3
25G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2
26outflow tract morphogenesisGO:00315110.5NPY1R, NPY5R, NPY2R
27behavioral response to cocaineGO:04814810.5DRD2, DRD3
28adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.5OPRM1, OPRK1, NPY2R, NPY1R
29response to iron ionGO:01003910.5SLC6A3, DRD2
30response to light stimulusGO:00941610.4PER1, DRD2
31response to drugGO:04249310.3DRD2, SLC6A4, DRD3, SLC6A3
32arachidonic acid secretionGO:05048210.2DRD2, DRD3
33synaptic transmissionGO:00726810.2PDYN, SLC6A3, SLC18A2, GABRA2, CARTPT, OPRK1
34neuropeptide signaling pathwayGO:00721810.2CARTPT, PDYN, POMC
35neurotransmitter transportGO:00683610.2GABRA2, CPLX4
36locomotory behaviorGO:00762610.1DRD2, SLC18A2, NPY1R, NPY2R, SLC6A3, DBH
37positive regulation of renal sodium excretionGO:03581510.0DRD2, DRD3

Molecular functions related to Cocaine Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.3SLC6A3, SLC6A4, SLC18A2
2peptide YY receptor activityGO:00160110.3NPY5R, NPY2R, NPY1R
3dopamine bindingGO:03524010.3DRD2, DRD3, SLC6A3
4neuropeptide Y receptor activityGO:00498310.3NPY5R, NPY2R, NPY1R
5pancreatic polypeptide receptor activityGO:00160210.3NPY5R, NPY1R
6serotonin transmembrane transporter activityGO:01522210.2SLC6A4, SLC18A2
7drug bindingGO:00814410.1SLC18A2, SLC6A3, DRD3, DRD2
8dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD3, DRD2

Products for genes affiliated with Cocaine Dependence

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Sources for Cocaine Dependence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet