MCID: CCC001
MIFTS: 70

Coccidioidomycosis malady

Rare diseases, Infectious diseases categories
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Summaries for Coccidioidomycosis

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8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Valley fever is a disease caused by a fungus (or mold) called coccidioides. the fungi live in the soil of dry areas like the southwestern u.s. you get it from inhaling the spores of the fungus. the infection cannot spread from person to person. anyone can get valley fever. but it's most common among older adults, especially those 60 and older. people who have recently moved to an area where it occurs are at highest risk for infection. other people at higher risk include workers in jobs that expose them to soil dust. these include construction workers, agricultural workers, and military forces doing field training. african americans and asians women in their third trimester of pregnancy people with weak immune systems valley fever is often mild, with no symptoms. if you have symptoms, they may include a flu-like illness, with fever, cough, headache, rash, and muscle aches. most people get better within several weeks or months. a small number of people may develop a chronic lung or widespread infection. valley fever is diagnosed by testing your blood, other body fluids, or tissues. many people with the acute infection get better without treatment. in some cases, doctors may prescribe antifungal drugs for acute infections. severe infections require antifungal drugs. centers for disease control and prevention

MalaCards: Coccidioidomycosis, also known as valley fever, is related to meningitis and pneumonia, and has symptoms including chest pain, arthritis and conjunctivitis. An important gene associated with Coccidioidomycosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Staphylococcus aureus infection and Cellular Transformation by HTLV1. The drugs ketoconazole and itraconazole and the compounds 1-methyltryptophan and zymosan have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in coccidioides immitis, transmitted by airborne spores and has symptom conjunctivitis, has symptom arthritis, has symptom chest pain and results in formation of skin nodules.

CDC:4 Valley fever, also called coccidioidomycosis, is an infection caused by the fungus Coccidioides. The fungus is known to live in the soil in the southwestern United States and parts of Mexico and Central and South America. The fungus was also recently found in south-central Washington. People can get valley fever by breathing in the microscopic fungal spores from the air, although most people who breathe in the spores don’t get sick. Usually, people who get sick with valley fever will get better on their own within weeks to months, but some people will need antifungal medication. Certain groups of people are at higher risk for becoming severely ill. It’s difficult to prevent exposure to Coccidioides in areas where it’s common in the environment, but people who are at higher risk for severe valley fever should try to avoid breathing in large amounts of dust if they’re in these areas.  

Wikipedia:65 Coccidioidomycosis (/k?k?s?di??do?ma??ko?s?s/, kok-sid-ee-oy-doh-my-KOH-sis), commonly known as cocci,... more...

Aliases & Classifications for Coccidioidomycosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 34MedlinePlus, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
coccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

coccidioidomycosis 8 43 10 45 49 62
valley fever 43 49 34
primary extrapulmonary coccidioidomycosis 8 62
coccidiosis 43 62
primary pulmonary coccidioidomycosis 62
coccidioides immitis infection 43
san joaquin valley fever 49
coccidioides infection 49
california disease 49
san joaquin fever 43
desert rheumatism 49
desert fever 49


External Ids:

Disease Ontology8 DOID:13450
ICD9CM27 114.9, 114
NCIt40 C84642
MeSH35 D003047
ICD10 via Orphanet26 B38.1, B38.2, B38.3 B38.4, B38.7, B38.8, B38.9, B38.0, more
MESH via Orphanet36 D003047
SNOMED-CT via Orphanet59 442543009, 60826002
UMLS via Orphanet63 C0009186
ICD1025 B38, B38.9

Related Diseases for Coccidioidomycosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Coccidioidomycosis:



Diseases related to coccidioidomycosis

Symptoms for Coccidioidomycosis

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8Disease Ontology
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Symptoms:

8
  • chest pain
  • arthritis
  • conjunctivitis

Drugs & Therapeutics for Coccidioidomycosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Coccidioidomycosis

Search NIH Clinical Center for Coccidioidomycosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Coccidioidomycosis

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Anatomical Context for Coccidioidomycosis

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33MalaCards
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MalaCards organs/tissues related to Coccidioidomycosis:

33
Lung, Testes, Skin, Liver, Brain, Prostate, Bone, Whole blood, T cells, B cells, Pancreas, Testis, Tongue, Kidney, Heart, Lymph node, Bone marrow

Animal Models for Coccidioidomycosis or affiliated genes

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37MGI
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Publications for Coccidioidomycosis

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52PubMed
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Articles related to Coccidioidomycosis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
A newly diagnosed Wegener's disease as the underlying cause for a disseminated coccidioidomycosis. (24156233)
2013
2
Routine CSF analysis in coccidioidomycosis is not required. (23717579)
2013
3
Rare manifestations of coccidioidomycosis. (24015425)
2013
4
Coccidioidomycosis: adenosine deaminase levels, serologic parameters, culture results, and polymerase chain reaction testing in pleural fluid. (23187746)
2013
5
Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. (23488972)
2013
6
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. (23541320)
2013
7
Biochemical characterization of an in-house Coccidioides antigen: perspectives for the immunodiagnosis of coccidioidomycosis. (22743589)
2012
8
A reformulated spherule-derived coccidioidin (Spherusol) to detect delayed-type hypersensitivity in coccidioidomycosis. (22669545)
2012
9
Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related peptide is characteristic of granulomatous inflammation. (22670039)
2012
10
Multiple lung abscesses caused by Actinomyces graevenitzii mimicking acute pulmonary coccidioidomycosis. (22760049)
2012
11
Serum (1->3)-I^-D-glucan measurement in coccidioidomycosis. (22692738)
2012
12
The utility of fine needle aspiration for diagnosis of extrapulmonary coccidioidomycosis: a case report and discussion. (21562136)
2011
13
Subclinical dissemination of coccidioidomycosis in a liver transplant recipient. (21744045)
2011
14
Reactivation of coccidioidomycosis despite antifungal prophylaxis in solid organ transplant recipients. (21516063)
2011
15
Pulmonary coccidioidomycosis. (22167403)
2011
16
Clinical and pathologic characteristics of disseminated cutaneous coccidioidomycosis. (20398813)
2010
17
Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States. (19934792)
2010
18
Twelve years of coccidioidomycosis in CearA! State, Northeast Brazil: epidemiologic and diagnostic aspects. (19117713)
2010
19
Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency. (19681704)
2009
20
Disseminated coccidioidomycosis: a case report from the United kingdom. (19294009)
2009
21
Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. (18781884)
2008
22
Acute pulmonary coccidioidomycosis: CT findings from 15 patients. (18508875)
2008
23
An unusual case of coccidioidomycosis presenting with skin lesions. (18806494)
2008
24
Coccidioidomycosis in rheumatology patients: incidence and potential risk factors. (17363440)
2007
25
Disseminated coccidioidomycosis in pregnancy. (17425401)
2007
26
Coccidioidomycosis in persons infected with HIV-1. (17363429)
2007
27
Disseminated coccidioidomycosis in a captive Indochinese tiger (Panthera tigris corbetti) with chronic renal disease. (17315442)
2006
28
Holocene coccidioidomycosis: Valley Fever in early Holocene bison (Bison antiquus). (17256570)
2006
29
Coccidioidomycosis of the prostate: a determination of incidence, report of 4 cases, and treatment recommendations. (15936822)
2006
30
Climate factors influencing coccidioidomycosis seasonality and outbreaks. (15929890)
2005
31
Disseminated coccidioidomycosis with cutaneous lesions clinically mimicking mycosis fungoides. (16336534)
2005
32
Coccidioidomycosis in liver transplant recipients relocating to an endemic area. (15628738)
2004
33
A cluster of disseminated coccidioidomycosis cases at a US military hospital. (12834136)
2003
34
Coccidioidomycosis mimicking lung cancer. (14732800)
2003
35
Coccidioidomycosis in Przewalski's horses (Equus przewalskii). (15077708)
2003
36
Donor transfer of pulmonary coccidioidomycosis in lung transplantation. (11834038)
2002
37
Reversal of coccidioidal anergy in vitro by dendritic cells from patients with disseminated coccidioidomycosis. (12165528)
2002
38
Coccidioidomycosis: efficacy of new agents and future prospects. (11964886)
2001
39
Serologic studies in coccidioidomycosis. (11740825)
2001
40
Primary pulmonary coccidioidomycosis. (11740823)
2001
41
Coccidioidomycosis complicating solid organ transplantation. (11740826)
2001
42
Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice. (11292702)
2001
43
Coccidioidomycosis in New York State. (10653565)
2000
44
Outbreak of coccidioidomycosis in Washington state residents returning from Mexico. (10619734)
2000
45
Coccidioidomycosis: a regional disease of national importance. Rethinking approaches for control. (10068388)
1999
46
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
47
Activity of the triazole SCH 56592 against disseminated murine coccidioidomycosis. (9210684)
1997
48
Disseminated coccidioidomycosis diagnosed by culture of a central venous catheter tip. (8824997)
1996
49
Coccidioidomycosis: the other great imitator. (7555099)
1995
50
Coccidioidomycosis with necrotizing granulomatous conjunctivitis. (7842715)
1994

Variations for Coccidioidomycosis

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Expression for genes affiliated with Coccidioidomycosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coccidioidomycosis

Search GEO for disease gene expression data for Coccidioidomycosis.

Pathways for genes affiliated with Coccidioidomycosis

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 5Cell Signaling Technology, 60Thomson Reuters, 38NCBI BioSystems Database, 54R&D Systems, 55Reactome
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Pathways related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MBL2, IL10
2
Show member pathways
9.5IFNGR1, IFNG
39.5IL10, TLR4
4
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4IFNG, STAT1
5
Show member pathways
IL-2 Signaling pathway38
9.4IFNG, STAT1
69.4IFNG, STAT1
79.4TLR4, IFNG
8
Show member pathways
9.3IL10, IFNG
99.3IL10, IFNG
109.3IFNG, IL10
119.3IL10, IFNG
129.3IL10, IFNG
139.3MBL2, CLEC7A, TLR4
14
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3TLR4, CLEC7A, STAT1
15
Show member pathways
9.1STAT1, IFNGR1, IFNG
169.1STAT1, IFNGR1, IFNG
179.1IFNG, IFNGR1, STAT1
18
Show member pathways
9.1IFNG, IFNGR1, STAT1
19
Show member pathways
IFN-gamma pathway38
9.1IFNG, IFNGR1, STAT1
209.1IFNG, IFNGR1, STAT1
219.1TLR4, IFNGR1, IFNG
22
Show member pathways
9.1IFNG, IFNGR1, TLR4
23
Show member pathways
9.0IFNGR1, IFNG, IL10
24
Show member pathways
9.0IFNG, STAT1, TLR4
25
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.9IL10, IFNG, STAT1
268.9IL10, IFNG, TLR4
278.9TLR4, IFNG, IL10
28
Show member pathways
8.7TLR4, STAT1, IFNGR1, IFNG
298.7TLR4, STAT1, IFNGR1, IFNG
30
Show member pathways
8.7TLR4, STAT1, IFNGR1, IFNG
31
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7TLR4, STAT1, IFNGR1, IFNG
32
Show member pathways
Immune response MIF in innate immunity response60
8.7IFNG, IFNGR1, STAT1, TLR4
33
Show member pathways
Type III interferon signaling38
8.6IL10, IFNG, IFNGR1, STAT1
34
Show member pathways
8.6IL10, IFNG, IFNGR1, STAT1
35
Show member pathways
8.6IL10, IFNG, IFNGR1, TLR4
36
Show member pathways
IL27-mediated signaling events38
8.1TLR4, STAT1, IFNGR1, IFNG, IL10
37
Show member pathways
8.1TLR4, STAT1, IFNGR1, IFNG, IL10
38
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.1IL10, IFNG, IFNGR1, STAT1, TLR4
397.8IL10, IFNG, IFNGR1, STAT1, CLEC7A, TLR4

Compounds for genes affiliated with Coccidioidomycosis

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
11-methyltryptophan459.7TLR4, IFNG
2zymosan459.7TLR4, CLEC7A, MBL2
3glucuronoxylomannan459.7IL10, TLR4
4betaseron459.6IFNG, IL10
5mannan459.5MBL3P, MBL2, TLR4
6lipoteichoic acid459.5MBL2, IL10, TLR4
7peptidoglycan45 2910.5TLR4, IL10, MBL2
8interferon gamma459.4IFNG, IL10
9anti-fungal459.4TLR4, IFNG, MBL2
10alpha-galactosylceramide459.3IFNG, IL10
11indoleamine459.3STAT1, IFNG, IL10
12echinacea459.3CD69, IL10
13neopterin459.3IFNG, IL10, MBL2
14il 10459.2TLR4, IFNG, IL10
15infliximab45 51 1111.2IL10, IFNG, TLR4
1615-deoxy-delta-12,14-prostaglandin j2459.2IL10, IFNG, STAT1
17ccl345 2910.2IL10, IFNG, TLR4
18vitamin d459.0TLR4, STAT1, IL10, MBL2
19prednisolone45 29 1111.0MBL2, IL10, IFNG
20n-acetylglucosamine459.0CD69, MBL3P, MBL2
21ribavirin45 51 1111.0STAT1, IFNG, IL10, MBL2
22polymyxin b458.9MBL2, IL10, IFNG, TLR4
23imiquimod45 61 29 1111.9TLR4, STAT1, IFNG, IL10
242,5-oligoadenylate458.9TLR4, STAT1, IFNG, IL10
25polyinosinic-polycytidylic acid458.9TLR4, STAT1, IFNG, IL10
26ifn-alpha458.9IL10, IFNG, STAT1, TLR4
27endotoxin458.9TLR4, STAT1, IFNG, IL10
28calcitriol45 61 24 1111.8TLR4, STAT1, IFNG, IL10
29sb 20358045 619.8IL10, IFNG, STAT1, TLR4
30carbohydrates458.7CD69, MBL2, TLR4
31polysaccharide458.6CD69, MBL3P, MBL2, TLR4
32herbimycin a45 619.6STAT1, IFNG, CD69
33poly(i-c)458.6TLR4, STAT1, IFNG, CD69
34tuberculin458.6CD69, MBL2, IL10, IFNG
35con a458.6IFNG, IL10, MBL2, CD69
36simvastatin45 51 61 29 24 1113.6IFNG, IL10, TLR4
37ly294002458.5TLR4, STAT1, IL10, CD69
38rantes458.5MBL2, IL10, IFNG, STAT1, TLR4
39allergens458.5TLR4, IFNG, IL10, CD69
40vegf458.5TLR4, STAT1, IFNG, IL10, MBL2
41tacrolimus45 51 1110.4TLR4, IFNG, IL10, CD69
42actinomycin d458.4CD69, IFNG, STAT1, TLR4
43mannose458.4TLR4, CLEC7A, MBL2, MBL3P, CD69
44genistein45 29 61 3 24 1113.4TLR4, STAT1, IFNG, CD69
45cyclosporin a45 29 6110.1TLR4, STAT1, IFNG, IL10, CD69
46pge2458.1TLR4, STAT1, IFNG, IL10, CD69
47tyrosine458.0TLR4, CLEC7A, STAT1, IFNGR1, MBL2, CD69
48cycloheximide458.0CD69, IL10, IFNG, STAT1, TLR4
49nitric oxide45 24 119.7TLR4, STAT1, IFNG, IL10, MBL2, CD69
50dexamethasone45 51 29 1110.4TLR4, CLEC7A, STAT1, IFNG, IL10, MBL2

GO Terms for genes affiliated with Coccidioidomycosis

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Sources:
16Gene Ontology
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Cellular components related to Coccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD69, IFNG, CLEC7A, TLR4

Biological processes related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phagocytosisGO:05076610.0MBL2, CLEC7A
2negative regulation of metanephric nephron tubule epithelial cell differentiationGO:0723089.8IFNG, STAT1
3defense response to protozoanGO:0428329.8IFNG, CLEC7A
4negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:0033409.8IFNG, STAT1
5negative regulation of interleukin-6 productionGO:0327159.7IL10, TLR4
6positive regulation of interleukin-12 biosynthetic processGO:0450849.7IFNG, TLR4
7lipopolysaccharide-mediated signaling pathwayGO:0316639.7STAT1, TLR4
8negative regulation of interleukin-17 productionGO:0327009.7TLR4, IFNG
9negative regulation of interferon-gamma productionGO:0326899.6IL10, TLR4
10positive regulation of interleukin-12 productionGO:0327359.5TLR4, IFNG
11regulation of interferon-gamma-mediated signaling pathwayGO:0603349.5STAT1, IFNGR1, IFNG
12interferon-gamma-mediated signaling pathwayGO:0603339.4STAT1, IFNGR1, IFNG
13positive regulation of nitric oxide biosynthetic processGO:0454299.4TLR4, IFNG
14negative regulation of tumor necrosis factor productionGO:0327209.4TLR4, IL10
15positive regulation of tumor necrosis factor productionGO:0327609.4TLR4, CLEC7A, IFNG
16negative regulation of growth of symbiont in hostGO:0441309.3MBL2, IL10, IFNG
17cytokine-mediated signaling pathwayGO:0192219.3IFNG, IFNGR1, STAT1
18positive regulation of MHC class II biosynthetic processGO:0453489.2IL10, IFNG, TLR4
19cellular response to lipopolysaccharideGO:0712229.2IL10, IFNG, TLR4
20positive regulation of mesenchymal cell proliferationGO:0020539.1IFNG, STAT1
21response to drugGO:0424938.9IL10, IFNG, STAT1
22defense response to bacteriumGO:0427428.8MBL2, IL10, IFNG, TLR4
23positive regulation of transcription from RNA polymerase II promoterGO:0459448.7TLR4, STAT1, IFNG, IL10

Products for genes affiliated with Coccidioidomycosis

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  • Antibodies
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Sources for Coccidioidomycosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet