MCID: CCC001
MIFTS: 68

Coccidioidomycosis malady

Infectious diseases category

Summaries for Coccidioidomycosis

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Valley fever is a disease caused by a fungus (or mold) called coccidioides. the fungi live in the soil of dry areas like the southwestern u.s. you get it from inhaling the spores of the fungus. the infection cannot spread from person to person. anyone can get valley fever. but it's most common among older adults, especially those 60 and older. people who have recently moved to an area where it occurs are at highest risk for infection. other people at higher risk include workers in jobs that expose them to soil dust. these include construction workers, agricultural workers, and military forces doing field training. african americans and asians women in their third trimester of pregnancy people with weak immune systems valley fever is often mild, with no symptoms. if you have symptoms, they may include a flu-like illness, with fever, cough, headache, rash, and muscle aches. most people get better within several weeks or months. a small number of people may develop a chronic lung or widespread infection. valley fever is diagnosed by testing your blood, other body fluids, or tissues. many people with the acute infection get better without treatment. in some cases, doctors may prescribe antifungal drugs for acute infections. severe infections require antifungal drugs. centers for disease control and prevention

MalaCards: Coccidioidomycosis, also known as valley fever, is related to hepatitis and encephalitis, and has symptoms including arthritis, chest pain and conjunctivitis. An important gene associated with Coccidioidomycosis is IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)), and among its related pathways are Th17 Differentiation and TGF-Beta Pathway. The drugs ketoconazole and itraconazole and the compounds pge2 and indoleamine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are integument and skeleton.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in coccidioides immitis, transmitted by airborne spores and has symptom conjunctivitis, has symptom arthritis, has symptom chest pain and results in formation of skin nodules.

CDC:3 Coccidioides is a fungus found in the soil of dry, low rainfall areas. It is endemic (native and common) in many areas of the southwestern United States, Mexico, Central and South America. Coccidioidomycosis, also known as Valley Fever, is a common cause of pneumonia in endemic areas. At least 30% – 60% of people who live in an endemic region are exposed to the fungus at some point during their lives. In most people the infection will go away on its own, but for people who develop severe infections or chronic pneumonia, medical treatment is necessary. Certain groups of people are at higher risk of developing severe disease. It is difficult to avoid exposure to Coccidioides, but people who are at higher risk should try to avoid breathing in large amounts of dust if they are in endemic areas.

Wikipedia:63 Coccidioidomycosis (/kɒkˌsɪdiɔɪdoʊmaɪˈkoʊsɪs/, kok-sid-ee-oy-doh-my-KOH-sis), commonly known... more...

Aliases & Classifications for Coccidioidomycosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
coccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

coccidioidomycosis 8 42 10 44 48 60
valley fever 42 48 33
primary extrapulmonary coccidioidomycosis 8 60
coccidiosis 42 60
primary pulmonary coccidioidomycosis 60
coccidioides immitis infection 42
san joaquin valley fever 48
coccidioides infection 48
california disease 48
san joaquin fever 42
desert rheumatism 48
desert fever 48


External Ids:

Disease Ontology8 DOID:13450
ICD9CM27 114.9, 114
NCIt39 C84642
MeSH34 D003047
ICD10 via Orphanet26 B38.1, B38.2, B38.3 B38.4, B38.7, B38.8, B38.9, B38.0, more
MESH via Orphanet35 D003047
SNOMED-CT via Orphanet57 442543009, 60826002
UMLS via Orphanet61 C0009186
ICD1025 B38, B38.9

Related Diseases for Coccidioidomycosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Coccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.8CD4, STAT1
2encephalitis30.6CD4
3histoplasmosis30.5CD4
4meningitis30.4CD4, MBL2
5cryptosporidiosis30.3CD4, MBL2
6pneumonia30.3IL10, CD4, MBL2, TLR4
7eosinophilia30.2IFNG, MBL2, STAT1, CD4, CD69, IL10
8peritonitis30.2CD69
9tuberculosis30.1TLR4, IFNG, IFNGR1, MBL2, STAT1, CD4
10diarrhea30.1CD4
11uveitis30.0IFNG, CD4, CD69, IL10
12lung cancer30.0CD4
13diabetes mellitus30.0CD4
14mycosis fungoides30.0CD4
15dermatitis30.0IFNG
16glomerulonephritis29.8MBL2
17toxoplasmosis29.8CD4
18listeriosis29.8CD4
19pancreatitis29.8IL10
20acquired immunodeficiency syndrome29.8CD4
21myeloid leukemia29.8STAT1, TLR4
22breast cancer29.8IFNGR1, STAT1, AGR2, CD4, CD69
23leukemia29.8TLR4, IFNG, MBL2, STAT1, CD4
24osteomyelitis29.8IFNGR1
25ovarian cancer29.8CD69
26leprosy29.8CD4
27cryptococcosis29.8CD4
28paracoccidioidomycosis29.8IL10
29candidiasis29.8CD4, IFNG
30lepromatous leprosy29.8IL10, IFNG
31atopic dermatitis29.7TLR4, IFNG, CD69, IL10
32sarcoidosis29.7IFNG, IFNGR1, STAT1, CD4, CD69
33rift valley fever11.4
34coccidiosis11.3
35west nile fever10.5
36crimean-congo hemorrhagic fever10.4
37blastomycosis10.3
38phlebotomus fever10.3
39encephalomyelitis10.3
40lassa fever10.2
41chikungunya10.2
42neurologic diseases10.2
43prostatitis10.2
44hepatitis a10.1
45cerebritis10.1
46hypercalcemia10.1
47sarcocystosis10.1
48pulmonary eosinophilia10.1
49newcastle disease10.0
50tick-borne encephalitis10.0

Graphical network of the top 20 diseases related to Coccidioidomycosis:



Diseases related to coccidioidomycosis

Clinical Features for Coccidioidomycosis

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Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • arthritis
  • chest pain
  • conjunctivitis

Drugs & Therapeutics for Coccidioidomycosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Coccidioidomycosis

Drug clinical trials:

Search ClinicalTrials for Coccidioidomycosis

Search NIH Clinical Center for Coccidioidomycosis

Search CenterWatch for Coccidioidomycosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Coccidioidomycosis

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Anatomical Context for Coccidioidomycosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Coccidioidomycosis:

32
Lung, Testes, Skin, Liver, Brain, Prostate, Bone, T cells, Whole blood, B cells, Testis, Heart, Pancreas, Bone marrow, Lymph node, Kidney, Tongue

Animal Models for Coccidioidomycosis or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Coccidioidomycosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.9CD4, TLR4
2MP:00053909.5STAT1, IFNGR1
3MP:00020069.1IFNG, IFNGR1, STAT1, IL10
4MP:00053817.6TLR4, IFNG, IFNGR1, STAT1, AGR2, CD4
5MP:00107687.1TLR4, IFNG, IFNGR1, STAT1, AGR2, CD4
6MP:00053847.1TLR4, IFNG, IFNGR1, STAT1, AGR2, CD4
7MP:00053977.0TLR4, IFNG, IFNGR1, MBL2, STAT1, AGR2
8MP:00053767.0TLR4, IFNG, IFNGR1, MBL2, STAT1, AGR2
9MP:00053876.6IL12A, TLR4, IFNG, IFNGR1, MBL2, STAT1

Publications for Coccidioidomycosis

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Sources:
50PubMed
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Articles related to Coccidioidomycosis:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
The utility of diagnostic testing for active coccidioidomycosis in solid organ transplant recipients. (23399074)
2013
2
Pulmonary Coccidioidomycosis After a Renal Transplant in a Nonendemic Region. (23742155)
2013
3
An unusual case of pulmonary coccidioidomycosis presenting as pneumothorax. (24245436)
2013
4
Rare systemic mycoses in cats: blastomycosis, histoplasmosis and coccidioidomycosis: ABCD guidelines on prevention and management. (23813828)
2013
5
JAMA patient page. Valley fever (coccidioidomycosis). (24327049)
2013
6
How natural disasters change natural patterns: coccidioidomycosis imported to New Orleans. (24015428)
2013
7
Immunological characterization of bronchoalveolar lavage fluid in patients with acute pulmonary coccidioidomycosis. (23737603)
2013
8
Teaching neuroimages: fungus in the brain: coccidioidomycosis meningoencephalitis. (23420900)
2013
9
Dectin-1 is required for resistance to coccidioidomycosis in mice. (23386437)
2013
10
Biochemical characterization of an in-house Coccidioides antigen: perspectives for the immunodiagnosis of coccidioidomycosis. (22743589)
2012
11
Donor-derived organ transplant transmission of coccidioidomycosis. (22176496)
2012
12
Coccidioidomycosis in armadillo hunters from the state of CearA!, Brazil. (22990973)
2012
13
Pulmonary and extrapulmonary coccidioidomycosis, active component, U.S. Armed Forces, 1999-2011. (23311328)
2012
14
Coccidioidomycosis-associated Deaths, United States, 1990-2008. (23092645)
2012
15
Reactivation of coccidioidomycosis despite antifungal prophylaxis in solid organ transplant recipients. (21516063)
2011
16
Coccidioidomycosis in African Americans. (21193657)
2011
17
Coccidioidomycosis in a cat imported from the USA to Portugal. (21765128)
2011
18
A case study of imported pulmonary coccidioidomycosis. (21462386)
2011
19
Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17). (21859851)
2011
20
Outcomes among inmates treated for coccidioidomycosis at a correctional institution during a community outbreak, Kern County, California, 2004. (19886797)
2009
21
Pulmonary coccidioidomycosis: import illness and the importance of travel history. (19915230)
2009
22
Pathology quiz case 1. Disseminated coccidioidomycosis of the infratemporal fossa. (19528414)
2009
23
Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. (18781884)
2008
24
Significance of isolated positive IgM serologic results by enzyme immunoassay for coccidioidomycosis. (18523863)
2008
25
Diagnosis and treatment of ocular coccidioidomycosis in a female captive chimpanzee (Pan troglodytes): a case study. (17303834)
2007
26
The complex immunology of human coccidioidomycosis. (17363432)
2007
27
Coccidioidomycosis: changing perceptions and creating opportunities for its control. (17344530)
2007
28
Coccidioidomycosis and pregnancy: a review. (17363444)
2007
29
Fluctuations in climate and incidence of coccidioidomycosis in Kern County, California: a review. (17347336)
2007
30
Safety, antigenicity, and efficacy of a recombinant coccidioidomycosis vaccine in cynomolgus macaques (Macaca fascicularis). (17347333)
2007
31
The prevention of recrudescent coccidioidomycosis after solid organ transplantation. (17496533)
2007
32
Posaconazole therapy for chronic refractory coccidioidomycosis. (17573510)
2007
33
Five-month-old infant with a unilateral pleural effusion. Coccidioidomycosis. (17259890)
2007
34
Holocene coccidioidomycosis: Valley Fever in early Holocene bison (Bison antiquus). (17256570)
2006
35
Coccidioidomycosis as a common cause of community-acquired pneumonia. (16707052)
2006
36
Coccidioidomycosis: a diagnostic challenge. (16317911)
2005
37
Refractory coccidioidomycosis treated with posaconazole. (15909265)
2005
38
Coccidioidomycosis of the eyelid. (15778675)
2005
39
Disseminated coccidioidomycosis. (15714666)
2005
40
Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis. (15155212)
2004
41
A vaccine against coccidioidomycosis is justified and attainable. (15283234)
2004
42
In vitro modulation of cytokine production by lymphocytes in human coccidioidomycosis. (12747952)
2003
43
Adjunctive corticosteroids therapy in acute respiratory distress syndrome owing to disseminated coccidioidomycosis. (12163812)
2002
44
Coccidioidomycosis in New York State. (10653565)
2000
45
Multi-organ failure caused by reactivated coccidioidomycosis without dissemination in a patient with renal transplantation. (10728738)
2000
46
Risk factors for acute symptomatic coccidioidomycosis among elderly persons in Arizona, 1996-1997. (10753733)
2000
47
Protective effects of erythema nodosum in coccidioidomycosis. (9923870)
1999
48
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
49
Coccidioidomycosis. (9189666)
1997
50
Coccidioidomycosis in 48 cats: a retrospective study (1984-1993) (7760314)
1995

Genetic Variations for Coccidioidomycosis

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Expression for genes affiliated with Coccidioidomycosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coccidioidomycosis

Search GEO for disease gene expression data for Coccidioidomycosis.

Pathways for genes affiliated with Coccidioidomycosis

About this section
Sources:
52R&D Systems, 51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
See all sources

Pathways related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Hide members
9.9CD4, IL12A
39.6CLEC7A, MBL2, TLR4
49.6TLR4, IL10, IL12A
59.6TLR4, IFNG, IL12A
69.5TLR4, IFNG, IFNGR1
79.5TLR4, IFNG, IFNGR1
89.5IL12A, IL10, IFNG
9
Hide members
9.5IL12A, IL10, IFNG
109.5IFNG, IL10, IL12A
119.5STAT1, CD4, IL12A
129.4IL10, CD4, IFNG
13
Immune response IFN gamma signaling pathway
Hide members
9.4STAT1, IFNGR1, IFNG
149.4STAT1, IFNGR1, IFNG
159.4STAT1, IFNGR1, IFNG
169.4STAT1, IFNGR1, IFNG
179.4IFNG, IFNGR1, STAT1
189.2TLR4, IFNG, IL10, IL12A
199.2TLR4, IFNG, IL10, IL12A
20
Hide members
9.1IL12A, CD4, STAT1, IFNG
219.1STAT1, IFNGR1, IFNG, TLR4
22
Hide members
9.1STAT1, IFNGR1, IFNG, TLR4
23
Immune response Bacterial infections in normal airways
9.1STAT1, IFNGR1, IFNG, TLR4
24
Hide members
9.1TLR4, IFNG, IFNGR1, STAT1
25
Hide members
9.1IFNG, IFNGR1, STAT1, CD4
26
Development PDGF signaling via STATs and NF-kB
Hide members
9.0IL10, CD4, STAT1, IFNG
27
Hide members
8.9IFNG, IFNGR1, CD4, IL10, IL12A
28
Hide members
8.9IL12A, STAT1, IFNGR1, IFNG, TLR4
29
Hide members
8.9IL12A, IL10, CD4, STAT1, TLR4
308.8IL12A, IL10, STAT1, IFNGR1, IFNG
31
Hide members
8.6TLR4, IFNG, IFNGR1, CD4, IL10, IL12A
32
Hide members
8.5TLR4, IFNG, IFNGR1, STAT1, IL10, IL12A
33
Hide members
8.5TLR4, IFNG, IFNGR1, STAT1, IL10, IL12A
34
Hide members
8.5TLR4, IFNG, IFNGR1, MBL2, STAT1, CD4
358.3TLR4, IFNG, IFNGR1, STAT1, CLEC7A, IL10
36
Hide members
8.2IL12A, TLR4, IFNG, IFNGR1, STAT1, CD4

Compounds for genes affiliated with Coccidioidomycosis

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24410.6CD4
2indoleamine4410.5STAT1
3endotoxin4410.4STAT1
4dexamethasone44 49 28 1113.3TLR4, CLEC7A
5cycloheximide4410.2CD4, STAT1
61-methyltryptophan4410.1TLR4, IFNG
7glucuronoxylomannan4410.1TLR4, IL10
8zymosan4410.0TLR4, MBL2, CLEC7A
9betaseron4410.0IL10, IFNG
10echinacea449.9CD69, IL10
11lipoteichoic acid449.9TLR4, MBL2, IL10
12interferon gamma449.9IFNG, IL10
13mycophenolate mofetil44 49 1111.9IL12A, IL10, IFNG
14peptidoglycan44 2810.8IL10, MBL2, TLR4
15anti-fungal449.8TLR4, IFNG, MBL2
16mdms449.8STAT1, CD4, IL10
17il 10449.8TLR4, IFNG, IL10
18infliximab44 49 1111.8IL10, IFNG, TLR4
19tarc449.7IL10, CD4, IFNG
20ccl344 2810.7TLR4, IFNG, IL10
21polymyxin b449.6IL10, MBL2, IFNG, TLR4
2215-deoxy-delta-12,14-prostaglandin j2449.6IL10, STAT1, IFNG
23neopterin449.6IFNG, MBL2, CD4, IL10
24chloroquine44 2 49 28 1113.5TLR4, CD4, IL10
25mannan449.5TLR4, MBL3P, MBL2, CD4
26imiquimod44 28 59 1112.5IL10, STAT1, IFNG, TLR4
27ribavirin44 49 1111.5IL10, STAT1, MBL2, IFNG
28polyinosinic-polycytidylic acid449.5TLR4, IFNG, STAT1, IL10
292,5-oligoadenylate449.5TLR4, IFNG, STAT1, IL10
30tuberculin449.5IFNG, MBL2, CD69, IL10
31ifn-alpha449.5TLR4, IFNG, STAT1, IL10
32alpha-galactosylceramide449.5IFNG, IL10
33con a449.5IFNG, MBL2, CD69, IL10
34allergens449.4IL10, CD69, IFNG, TLR4
35calcitriol44 59 11 2412.4IL10, STAT1, IFNG, TLR4
36poly(i-c)449.4CD69, STAT1, IFNG, TLR4
37tacrolimus44 49 1111.4TLR4, IFNG, CD69, IL10
38herbimycin a44 5910.3CD69, CD4, STAT1, IFNG
39n-acetylglucosamine449.3CD69, MBL2, MBL3P
40vitamin d449.3IL10, STAT1, MBL2, TLR4
41rantes449.2TLR4, IFNG, MBL2, STAT1, CD4
42sb 20358044 5910.2IL10, STAT1, IFNG, TLR4
43zidovudine44 1110.1IL10, CD4, NT5C
44genistein44 28 59 2 11 2414.0TLR4, IFNG, STAT1, CD4, CD69
45polysaccharide449.0CD69, CD4, MBL2, MBL3P, TLR4
46cyclosporin a44 28 5911.0TLR4, IFNG, STAT1, CD69, IL10
47ly294002449.0IL10, CD69, STAT1, TLR4
48mannose448.8CLEC7A, CD69, CD4, MBL2, MBL3P, TLR4
49nitric oxide44 11 2410.7IL10, CD69, STAT1, MBL2, IFNG, TLR4
50tyrosine448.4TLR4, IFNGR1, MBL2, STAT1, CD4, CD69

GO Terms for genes affiliated with Coccidioidomycosis

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Sources:
16Gene Ontology
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Cellular components related to Coccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8CLEC7A, CD69, CD4, IFNG, TLR4

Biological processes related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smooth muscle cell apoptotic processGO:03439310.0IFNG, IL12A
2positive regulation of interleukin-12 biosynthetic processGO:04508410.0TLR4, IFNG
3negative regulation of metanephric nephron tubule epithelial cell differentiationGO:0723089.9STAT1, IFNG
4positive regulation of phagocytosisGO:0507669.9CLEC7A, MBL2
5negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:0033409.9STAT1, IFNG
6defense response to protozoanGO:0428329.9IFNG, CLEC7A, IL12A
7negative regulation of interleukin-17 productionGO:0327009.9IL12A, IFNG, TLR4
8negative regulation of interleukin-6 productionGO:0327159.8TLR4, IL10
9positive regulation of tumor necrosis factor productionGO:0327609.8TLR4, IFNG, CLEC7A
10positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG, TLR4
11negative regulation of growth of symbiont in hostGO:0441309.8IFNG, MBL2, IL10
12defense response to Gram-negative bacteriumGO:0508299.8CD4, TLR4
13regulation of interferon-gamma-mediated signaling pathwayGO:0603349.7IFNG, IFNGR1, STAT1
14response to virusGO:0096159.7IL12A, IFNGR1, IFNG
15cellular response to lipopolysaccharideGO:0712229.6IL10, IFNG, TLR4
16interferon-gamma-mediated signaling pathwayGO:0603339.6IFNG, IFNGR1, STAT1
17positive regulation of interleukin-12 productionGO:0327359.5IFNG, TLR4
18defense response to bacteriumGO:0427429.4TLR4, IFNG, MBL2, IL10

Molecular functions related to Coccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IL12A, IL10, IFNG
2transmembrane signaling receptor activityGO:0048889.1CD69, CD4, TLR4

Products for genes affiliated with Coccidioidomycosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coccidioidomycosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet