MCID: CCC001
MIFTS: 63

Coccidioidomycosis malady

Infectious category

Summaries for Coccidioidomycosis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Valley fever is a disease caused by a fungus (or mold) called coccidioides. the fungi live in the soil of dry areas like the southwestern u.s. you get it from inhaling the spores of the fungus. the infection cannot spread from person to person. anyone can get valley fever. but it's most common among older adults, especially those 60 and older. people who have recently moved to an area where it occurs are at highest risk for infection. other people at higher risk include workers in jobs that expose them to soil dust. these include construction workers, agricultural workers, and military forces doing field training. african americans and asians women in their third trimester of pregnancy people with weak immune systems valley fever is often mild, with no symptoms. if you have symptoms, they may include a flu-like illness, with fever, cough, headache, rash, and muscle aches. most people get better within several weeks or months. a small number of people may develop a chronic lung or widespread infection. valley fever is diagnosed by testing your blood, other body fluids, or tissues. many people with the acute infection get better without treatment. in some cases, doctors may prescribe antifungal drugs for acute infections. severe infections require antifungal drugs. centers for disease control and prevention

MalaCards: Coccidioidomycosis, also known as valley fever, is related to cryptosporidiosis and hepatitis c, and has symptoms including conjunctivitis, chest pain and arthritis. An important gene associated with Coccidioidomycosis is IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)), and among its related pathways are Th17 Differentiation and TGF-Beta Pathway. The drugs ketoconazole and itraconazole and the compounds pge2 and indoleamine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are integument and skeleton.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in coccidioides immitis, transmitted by airborne spores and has symptom conjunctivitis, has symptom arthritis, has symptom chest pain and results in formation of skin nodules.

CDC:3 Coccidioides is a fungus found in the soil of dry, low rainfall areas. It is endemic (native and common) in many areas of the southwestern United States, Mexico, Central and South America. Coccidioidomycosis, also known as Valley Fever, is a common cause of pneumonia in endemic areas. At least 30% – 60% of people who live in an endemic region are exposed to the fungus at some point during their lives. In most people the infection will go away on its own, but for people who develop severe infections or chronic pneumonia, medical treatment is necessary. Certain groups of people are at higher risk of developing severe disease. It is difficult to avoid exposure to Coccidioides, but people who are at higher risk should try to avoid breathing in large amounts of dust if they are in endemic areas.

Wikipedia:64 Coccidioidomycosis (/kɒkˌsɪdiɔɪdoʊmaɪˈkoʊsɪs/, kok-sid-ee-oy-doh-my-KOH-sis), commonly known... more...

Aliases & Classifications for Coccidioidomycosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 34MedlinePlus, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
coccidioidomycosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

coccidioidomycosis 8 43 10 45 49 61
valley fever 43 49 34
primary extrapulmonary coccidioidomycosis 8 61
coccidiosis 43 61
primary pulmonary coccidioidomycosis 61
coccidioides immitis infection 43
san joaquin valley fever 49
coccidioides infection 49
california disease 49
san joaquin fever 43
desert rheumatism 49
desert fever 49


External Ids:

Disease Ontology8 DOID:13450
ICD9CM27 114.9, 114
NCIt40 C84642
MeSH35 D003047
MESH via Orphanet36 D003047
ICD10 via Orphanet26 B38
SNOMED-CT via Orphanet58 442543009, 60826002
UMLS via Orphanet62 C0009186
ICD1025 B38, B38.9

Related Diseases for Coccidioidomycosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Coccidioidomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1cryptosporidiosis30.4CD4, MBL2
2hepatitis c30.3TLR4, IFNG, STAT1, CD69, IL10
3tuberculosis30.1TLR4, IFNG, IFNGR1, MBL2, STAT1, CD4
4mycosis fungoides30.1CD4
5uveitis30.0IFNG, CD4, CD69, IL10
6septic shock30.0IL10, MBL2, TLR4
7toxoplasmosis29.9CD4
8listeriosis29.9CD4
9acquired immunodeficiency syndrome29.9CD4
10cryptococcosis29.8CD4
11paracoccidioidomycosis29.8IL10
12lupus nephritis29.8MBL2, IL10
13lepromatous leprosy29.8IL10, IFNG
14atopic dermatitis29.8TLR4, IFNG, CD69, IL10
15rift valley fever11.4
16q fever10.6
17west nile fever10.5
18hemorrhagic fever10.5
19crimean-congo hemorrhagic fever10.4
20west nile virus10.4
21blastomycosis10.3
22phlebotomus fever10.3
23hepatitis e10.2
24lassa fever10.2
25chikungunya10.2
26hypercalcemia10.1
27sarcocystosis10.1
28newcastle disease10.1
29tick-borne encephalitis10.1
30marburg hemorrhagic fever10.1
31ebola hemorrhagic fever10.1
32dengue hemorrhagic fever10.1
33japanese encephalitis10.1
34venezuelan equine encephalitis10.1
35viral encephalitis10.1
36hepatorenal syndrome10.1
37hepatitis d10.1
38yellow fever10.1
39lymphogranuloma venereum10.1
40hydranencephaly10.1
41west nile encephalitis10.1
42char syndrome10.1
43anterior uveitis10.1
44viral hemorrhagic fever10.1
45hepatitis c virus10.1
46endotheliitis10.1
47skeletal tuberculosis10.1
48constrictive pericarditis10.1
49endometriosis10.0CD69
50human immunodeficiency virus infectious disease10.0CD69

Graphical network of the top 20 diseases related to Coccidioidomycosis:



Diseases related to coccidioidomycosis

Clinical Features for Coccidioidomycosis

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • conjunctivitis
  • chest pain
  • arthritis

Drugs & Therapeutics for Coccidioidomycosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Coccidioidomycosis

Drug clinical trials:

Search ClinicalTrials for Coccidioidomycosis

Search NIH Clinical Center for Coccidioidomycosis

Search CenterWatch for Coccidioidomycosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Coccidioidomycosis

Anatomical Context for Coccidioidomycosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Coccidioidomycosis:

33
Skin, Liver, Tongue, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Heart, Pancreas, Adrenal gland, Prostate, Testis, T cells, B cells

Animal Models for Coccidioidomycosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Coccidioidomycosis

Sources:
51PubMed
See all sources

Articles related to Coccidioidomycosis:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related peptide is characteristic of granulomatous inflammation. (22670039)
2012
2
Coccidioidomycosis of cervical lymph nodes in an HIV-infected patient with immunologic reconstitution on potent HAART: a rare observation in a nonendemic area. (22104185)
2012
3
Coccidioidomycosis. (23068145)
2012
4
Vertebral coccidioidomycosis: presentation and multidisciplinary management. (22340929)
2012
5
The utility of fine needle aspiration for diagnosis of extrapulmonary coccidioidomycosis: a case report and discussion. (21562136)
2011
6
Musculoskeletal coccidioidomycosis. (22081286)
2011
7
Coccidioidomycosis in Chennai. (21751654)
2011
8
Chronic coccidioidomycosis endophthalmitis without concomitant systemic involvement: a clinicopathological case report. (20471688)
2010
9
The diagnosis of coccidioidomycosis. (20948866)
2010
10
Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis. (19072555)
2009
11
Surgery for pulmonary coccidioidomycosis: a 10-year experience. (19932232)
2009
12
Coccidioidomycosis in a 38-year-old man: a case report. (18619197)
2008
13
Amphotericin B and coccidioidomycosis. (17513463)
2007
14
The public health need and present status of a vaccine for the prevention of coccidioidomycosis. (17344529)
2007
15
The role of IL-10 in genetic susceptibility to coccidioidomycosis on mice. (17363443)
2007
16
Histopathologic findings of disseminated coccidioidomycosis with hyphae. (17438198)
2007
17
Experimental animal models of coccidioidomycosis. (17344524)
2007
18
Diagnosis of coccidioidomycosis by culture: safety considerations, traditional methods, and susceptibility testing. (17363439)
2007
19
What is your diagnosis? Disseminated coccidioidomycosis. (16570668)
2006
20
Coccidioidomycosis after renal transplantation in an endemic area. (16426318)
2006
21
Coccidioidomycosis and blastomycosis: advances in molecular diagnosis. (16043334)
2005
22
Coccidioidomycosis. (16206093)
2005
23
Coccidioidomycosis in persons infected with HIV type 1. (16163637)
2005
24
Coccidioidomycosis in hematopoietic stem cell transplant recipients. (16422300)
2005
25
Coccidioidomycosis causing massive cervical lymphadenopathy. (15510010)
2004
26
Pathology case of the month. Occupational hazard? Coccidioidomycosis (Coccidioides immitis). (14506823)
2003
27
Clinical, clinicopathologic, and radiographic findings in dogs with coccidioidomycosis: 24 cases (1995-2000). (12597419)
2003
28
Use of liposomal amphotericin B in the treatment of disseminated coccidioidomycosis. (14620712)
2003
29
Coccidioidomycosis: case report and update on diagnosis and management. (12004318)
2002
30
Disseminated coccidioidomycosis discovered during routine skin cancer screening. (12184677)
2002
31
Coccidioidomycosis: efficacy of new agents and future prospects. (11964886)
2001
32
Primary pulmonary coccidioidomycosis. (11740823)
2001
33
Coccidioidomycosis in workers at an archeologic site--Dinosaur National Monument, Utah, June-July 2001. (11724157)
2001
34
Reactivated laryngeal coccidioidomycosis. (11458233)
2001
35
Proceedings of the forty-fourth annual coccidioidomycosis study group meeting. Berkeley, California, USA, April 1, 2000. (11922019)
2001
36
Coccidioidomycosis presenting as testicular mass. (11547090)
2001
37
Airway coccidioidomycosis--report of cases and review. (10451165)
1999
38
Influence of host genetics on the severity of coccidioidomycosis. (10511523)
1999
39
Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic area. (10421859)
1999
40
Successful treatment of disseminated coccidioidomycosis with amphotericin B lipid complex. (9515680)
1998
41
Risk factors for primary pulmonary coccidioidomycosis hospitalizations among United States Navy and Marine Corps personnel, 1981-1994. (9546408)
1998
42
Update on treatment of coccidioidomycosis. (9074341)
1997
43
A case of disseminated coccidioidomycosis--autopsy report. (8843009)
1996
44
Bilateral isolated adrenal coccidioidomycosis. (8772628)
1996
45
Coccidioidomycosis: the other great imitator. (7555099)
1995
46
Coccidioidomycosis of the central nervous system: neuropathological and vasculopathic manifestations and clinical correlates. (7742448)
1995
47
Coccidioidomycosis with necrotizing granulomatous conjunctivitis. (7842715)
1994
48
Diabetic ketoacidosis associated with pulmonary coccidioidomycosis. (8086561)
1994
49
Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis. (2393272)
1990
50
Clinical usefulness of skin testing in histoplasmosis, coccidioidomycosis, and blastomycosis. This Official Statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1987. (3202445)
1988

Genetic Variations for Coccidioidomycosis

Expression for genes affiliated with Coccidioidomycosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Coccidioidomycosis

Search GEO for disease gene expression data for Coccidioidomycosis.

Pathways for genes affiliated with Coccidioidomycosis

Sources:
53R&D Systems, 52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Hide members
9.9CD4, IL12A
39.6TLR4, MBL2, CLEC7A
49.6IL10, IL12A, TLR4
59.6IFNG, TLR4, IL12A
69.5IFNG, TLR4, IFNGR1
79.5IFNG, IFNGR1, TLR4
89.5IL12A, IL10, IFNG
99.5IL12A, IFNG, IL10
10
Hide members
9.5IFNG, IL12A, IL10
119.5CD4, STAT1, IL12A
129.4CD4, IL10, IFNG
139.4IFNGR1, IFNG, STAT1
149.4STAT1, IFNGR1, IFNG
159.4STAT1, IFNGR1, IFNG
16
Immune response IFN gamma signaling pathway
Hide members
9.4IFNGR1, STAT1, IFNG
179.4IFNG, IFNGR1, STAT1
189.2IL10, IFNG, IL12A, TLR4
199.2TLR4, IFNG, IL10, IL12A
20
Hide members
9.1IFNG, STAT1, CD4, IL12A
21
Hide members
9.1STAT1, IFNG, TLR4, IFNGR1
229.1TLR4, IFNG, STAT1, IFNGR1
23
Hide members
9.1TLR4, IFNG, STAT1, IFNGR1
24
Immune response Bacterial infections in normal airways
9.1IFNG, TLR4, STAT1, IFNGR1
25
Hide members
9.1STAT1, IFNGR1, IFNG, CD4
26
Development PDGF signaling via STATs and NF-kB
Hide members
9.0CD4, IL10, STAT1, IFNG
27
Hide members
8.9IL12A, IL10, IFNG, IFNGR1, CD4
28
Hide members
8.9IL12A, STAT1, IFNGR1, IFNG, TLR4
29
Hide members
8.9IL12A, STAT1, CD4, IL10, TLR4
308.8IL10, IFNGR1, STAT1, IFNG, IL12A
31
Hide members
8.6TLR4, IFNG, IFNGR1, CD4, IL10, IL12A
32
Hide members
8.5IL10, TLR4, IFNG, IL12A, STAT1, IFNGR1
33
Hide members
8.5IFNG, IFNGR1, STAT1, IL10, IL12A, TLR4
34
Hide members
8.5TLR4, MBL2, STAT1, CD4, IFNG, IFNGR1
358.3IFNG, IL12A, IFNGR1, TLR4, CLEC7A, STAT1
36
Hide members
8.2IFNGR1, STAT1, CD4, IL12A, TLR4, IL10

Compounds for genes affiliated with Coccidioidomycosis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24510.6CD4
2indoleamine4510.5STAT1
3endotoxin4510.4STAT1
4dexamethasone45 50 29 1113.3TLR4, CLEC7A
5cycloheximide4510.2STAT1, CD4
61-methyltryptophan4510.1TLR4, IFNG
7glucuronoxylomannan4510.1IL10, TLR4
8zymosan4510.0MBL2, CLEC7A, TLR4
9betaseron4510.0IFNG, IL10
10echinacea459.9CD69, IL10
11lipoteichoic acid459.9MBL2, IL10, TLR4
12interferon gamma459.9IFNG, IL10
13mycophenolate mofetil45 50 1111.9IFNG, IL10, IL12A
14peptidoglycan45 2910.8MBL2, IL10, TLR4
15anti-fungal459.8MBL2, IFNG, TLR4
16mdms459.8IL10, STAT1, CD4
17il 10459.8TLR4, IFNG, IL10
18infliximab45 50 1111.8TLR4, IL10, IFNG
19tarc459.7CD4, IL10, IFNG
20ccl345 2910.7IFNG, TLR4, IL10
21polymyxin b459.6MBL2, IL10, TLR4, IFNG
2215-deoxy-delta-12,14-prostaglandin j2459.6IFNG, IL10, STAT1
23neopterin459.6CD4, MBL2, IFNG, IL10
24chloroquine45 2 50 29 1113.5CD4, IL10, TLR4
25mannan459.5TLR4, MBL3P, MBL2, CD4
26imiquimod45 29 60 1112.5IL10, IFNG, STAT1, TLR4
27ribavirin45 50 1111.5IL10, IFNG, STAT1, MBL2
282,5-oligoadenylate459.5STAT1, TLR4, IL10, IFNG
29polyinosinic-polycytidylic acid459.5IL10, IFNG, TLR4, STAT1
30tuberculin459.5IFNG, MBL2, CD69, IL10
31ifn-alpha459.5IFNG, IL10, TLR4, STAT1
32alpha-galactosylceramide459.5IL10, IFNG
33con a459.5MBL2, IFNG, CD69, IL10
34allergens459.4IFNG, TLR4, CD69, IL10
35calcitriol45 60 11 2412.4IL10, IFNG, TLR4, STAT1
36poly(i-c)459.4STAT1, CD69, IFNG, TLR4
37tacrolimus45 50 1111.4TLR4, IL10, CD69, IFNG
38herbimycin a45 6010.3STAT1, CD4, IFNG, CD69
39n-acetylglucosamine459.3MBL2, CD69, MBL3P
40vitamin d459.3TLR4, MBL2, STAT1, IL10
41rantes459.2CD4, IFNG, TLR4, MBL2, STAT1
42sb 20358045 6010.2IFNG, TLR4, STAT1, IL10
43zidovudine45 1110.1IL10, NT5C, CD4
44genistein45 29 60 2 11 2414.0IFNG, CD69, CD4, STAT1, TLR4
45polysaccharide459.0TLR4, MBL3P, MBL2, CD4, CD69
46cyclosporin a45 29 6011.0IL10, TLR4, IFNG, CD69, STAT1
47ly294002459.0TLR4, IL10, CD69, STAT1
48mannose458.8MBL3P, TLR4, MBL2, CLEC7A, CD4, CD69
49nitric oxide45 11 2410.7IFNG, IL10, TLR4, MBL2, CD69, STAT1
50tyrosine458.4CD69, STAT1, MBL2, IFNGR1, TLR4, CLEC7A

GO Terms for genes affiliated with Coccidioidomycosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Coccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8CLEC7A, CD69, CD4, IFNG, TLR4

Biological processes related to Coccidioidomycosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smooth muscle cell apoptotic processGO:03439310.0IFNG, IL12A
2negative regulation of metanephric nephron tubule epithelial cell differentiationGO:0723089.9IFNG, STAT1
3positive regulation of phagocytosisGO:0507669.9CLEC7A, MBL2
4positive regulation of interleukin-12 biosynthetic processGO:0450849.9IFNG, TLR4
5negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:0033409.9IFNG, STAT1
6defense response to protozoanGO:0428329.9IFNG, CLEC7A, IL12A
7negative regulation of interleukin-17 productionGO:0327009.9IL12A, TLR4, IFNG
8negative regulation of interleukin-6 productionGO:0327159.8IL10, TLR4
9positive regulation of tumor necrosis factor productionGO:0327609.8TLR4, IFNG, CLEC7A
10positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG, TLR4
11negative regulation of growth of symbiont in hostGO:0441309.8IL10, MBL2, IFNG
12defense response to Gram-negative bacteriumGO:0508299.8CD4, TLR4
13regulation of interferon-gamma-mediated signaling pathwayGO:0603349.7IFNGR1, STAT1, IFNG
14response to virusGO:0096159.7IL12A, IFNG, IFNGR1
15cellular response to lipopolysaccharideGO:0712229.6IL10, IFNG, TLR4
16interferon-gamma-mediated signaling pathwayGO:0603339.6STAT1, IFNGR1, IFNG
17positive regulation of interleukin-12 productionGO:0327359.5IFNG, TLR4
18defense response to bacteriumGO:0427429.4IFNG, IL10, MBL2, TLR4

Molecular functions related to Coccidioidomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IL12A, IL10, IFNG
2transmembrane signaling receptor activityGO:0048889.1CD69, CD4, TLR4

Products for genes affiliated with Coccidioidomycosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coccidioidomycosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet