MCID: CCC001
MIFTS: 63

Coccidioidomycosis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Coccidioidomycosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 2CDC, 61UMLS, 32MedlinePlus, 56SNOMED-CT, 33MeSH, 27ICD9CM, 39NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Coccidioidomycosis:

Name: Coccidioidomycosis 8 42 10 44 48 2 61
Valley Fever 42 48 32 2
Primary Extrapulmonary Coccidioidomycosis 8 61
Coccidiosis 42 61
Primary Pulmonary Coccidioidomycosis 61
Coccidioides Immitis Infection 42
San Joaquin Valley Fever 48
 
Coccidioides Infection 48
Enteric Coccidiosis 61
California Disease 48
San Joaquin Fever 42
Desert Rheumatism 48
Desert Fever 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
coccidioidomycosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology8 DOID:13450
MeSH33 D003047
ICD9CM27 114.9, 114
NCIt39 C84642
Orphanet48 228123
MESH via Orphanet34 D003047
ICD10 via Orphanet26 B38.0, B38.1, B38.2 B38.3, B38.4, B38.7, B38.8, B38.9, more
UMLS via Orphanet62 C0009186
ICD1025 B38, B38.9

Summaries for Coccidioidomycosis

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MedlinePlus:32 Valley fever is a disease caused by a fungus (or mold) called coccidioides. the fungi live in the soil of dry areas like the southwestern u.s. you get it from inhaling the spores of the fungus. the infection cannot spread from person to person. anyone can get valley fever. but it's most common among older adults, especially those 60 and older. people who have recently moved to an area where it occurs are at highest risk for infection. other people at higher risk include workers in jobs that expose them to soil dust. these include construction workers, agricultural workers, and military forces doing field training. african americans and asians women in their third trimester of pregnancy people with weak immune systems valley fever is often mild, with no symptoms. if you have symptoms, they may include a flu-like illness, with fever, cough, headache, rash, and muscle aches. most people get better within several weeks or months. a small number of people may develop a chronic lung or widespread infection. valley fever is diagnosed by testing your blood, other body fluids, or tissues. many people with the acute infection get better without treatment. in some cases, doctors may prescribe antifungal drugs for acute infections. severe infections require antifungal drugs. centers for disease control and prevention

MalaCards based summary: Coccidioidomycosis, also known as valley fever, is related to meningitis and candidiasis, and has symptoms including conjunctivitis, arthritis and chest pain. An important gene associated with Coccidioidomycosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Staphylococcus aureus infection and Cellular Transformation by HTLV1. The drugs fluconazole and ketoconazole and the compounds 1-methyltryptophan and zymosan have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in coccidioides immitis, transmitted by airborne spores and has symptom conjunctivitis, has symptom arthritis, has symptom chest pain and results in formation of skin nodules.

CDC:2 Valley fever, also called coccidioidomycosis, is an infection caused by the fungus Coccidioides. The fungus is known to live in the soil in the southwestern United States and parts of Mexico and Central and South America. The fungus was also recently found in south-central Washington. People can get valley fever by breathing in the microscopic fungal spores from the air, although most people who breathe in the spores don’t get sick. Usually, people who get sick with valley fever will get better on their own within weeks to months, but some people will need antifungal medication. Certain groups of people are at higher risk for becoming severely ill. It’s difficult to prevent exposure to Coccidioides in areas where it’s common in the environment, but people who are at higher risk for severe valley fever should try to avoid breathing in large amounts of dust if they’re in these areas.  

Wikipedia:64 Coccidioidomycosis (/k?k?s?di??do?ma??ko?s?s/, kok-sid-ee-oy-doh-my-KOH-sis), commonly known as cocci,... more...

Related Diseases for Coccidioidomycosis

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Diseases related to Coccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.1MBL2
2candidiasis30.5IFNG
3pneumonia30.1IL10, TLR4, MBL2
4hiv-130.1CD69, STAT1, TLR4
5uveitis30.0IFNG, CD69, IL10
6lepromatous leprosy30.0IL10, IFNG
7lupus nephritis29.9MBL2, IL10
8influenza29.7STAT1, MBL3P, IFNG, CD69, MBL2
9eosinophilia29.7STAT1, MBL2, IL10, CD69, IFNG
10leukemia29.4MBL2, IFNG, STAT1, TLR4
11atopic dermatitis29.4IFNG, IL10, CD69, TLR4
12tuberculosis28.6STAT1, CLEC7A, MBL2, TLR4, IL10, IFNG
13rift valley fever11.5
14coccidiosis11.3
15hemorrhagic fever10.5
16encephalitis10.5
17mycobacterium avium complex disease10.5IFNGR1
18crimean-congo hemorrhagic fever10.4
19histoplasmosis10.4
20thyroiditis10.4MBL2
21blastomycosis10.4
22filariasis10.4TLR4
23cryptosporidiosis10.3
24atypical mycobacteriosis, familial10.3IFNGR1, STAT1
25toxic shock syndrome10.2CD69, IFNG
26west nile virus10.2
27west nile fever10.2
28chikungunya10.2
29brucellosis10.2
30neurologic diseases10.2
31viral hemorrhagic fever10.2
32peritonitis10.2
33prostatitis10.2
34neisseria meningitidis infection10.2MBL2, TLR4
35hypercalcemia10.2
36cerebritis10.2
37sarcocystosis10.1
38diarrhea10.1
39synovitis10.1CD69, STAT1
40pulmonary eosinophilia10.1
41skin disease10.1
42newcastle disease10.1
43venezuelan equine encephalitis10.1
44lassa fever10.1
45japanese encephalitis10.1
46viral encephalitis10.1
47hepatorenal syndrome10.1
48yellow fever10.1
49hepatitis a10.1
50hydranencephaly10.1

Graphical network of the top 20 diseases related to Coccidioidomycosis:



Diseases related to coccidioidomycosis

Symptoms for Coccidioidomycosis

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Symptoms:

 8
  • conjunctivitis
  • arthritis
  • chest pain

Drugs & Therapeutics for Coccidioidomycosis

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Drug clinical trials:

Search ClinicalTrials for Coccidioidomycosis

Search NIH Clinical Center for Coccidioidomycosis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Coccidioidomycosis

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Anatomical Context for Coccidioidomycosis

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MalaCards organs/tissues related to Coccidioidomycosis:

31
Lung, Testes, Skin, Liver, Brain, Prostate, Whole blood, T cells, Bone, Lymph node, Heart, Kidney, Pancreas, Testis, B cells, Tongue, Neutrophil

Animal Models for Coccidioidomycosis or affiliated genes

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Publications for Coccidioidomycosis

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Articles related to Coccidioidomycosis:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Coccidioidomycosis and other systemic mycoses of marine mammals stranding along the central california, USA coast: 1998-2012. (25647598)
2015
2
Empyema necessitatis: unique presentation in a coccidioidomycosis case. (25876208)
2015
3
Distance from construction site and risk for coccidioidomycosis, Arizona, USA. (25148473)
2014
4
A newly diagnosed Wegener's disease as the underlying cause for a disseminated coccidioidomycosis. (24156233)
2013
5
Routine CSF analysis in coccidioidomycosis is not required. (23717579)
2013
6
Rare manifestations of coccidioidomycosis. (24015425)
2013
7
Coccidioidomycosis: adenosine deaminase levels, serologic parameters, culture results, and polymerase chain reaction testing in pleural fluid. (23187746)
2013
8
Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. (23488972)
2013
9
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. (23541320)
2013
10
Biochemical characterization of an in-house Coccidioides antigen: perspectives for the immunodiagnosis of coccidioidomycosis. (22743589)
2012
11
A reformulated spherule-derived coccidioidin (Spherusol) to detect delayed-type hypersensitivity in coccidioidomycosis. (22669545)
2012
12
Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related peptide is characteristic of granulomatous inflammation. (22670039)
2012
13
Multiple lung abscesses caused by Actinomyces graevenitzii mimicking acute pulmonary coccidioidomycosis. (22760049)
2012
14
Serum (1->3)-I^-D-glucan measurement in coccidioidomycosis. (22692738)
2012
15
The utility of fine needle aspiration for diagnosis of extrapulmonary coccidioidomycosis: a case report and discussion. (21562136)
2011
16
Subclinical dissemination of coccidioidomycosis in a liver transplant recipient. (21744045)
2011
17
Reactivation of coccidioidomycosis despite antifungal prophylaxis in solid organ transplant recipients. (21516063)
2011
18
Pulmonary coccidioidomycosis. (22167403)
2011
19
Clinical and pathologic characteristics of disseminated cutaneous coccidioidomycosis. (20398813)
2010
20
Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States. (19934792)
2010
21
Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency. (19681704)
2009
22
Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. (18781884)
2008
23
Acute pulmonary coccidioidomycosis: CT findings from 15 patients. (18508875)
2008
24
An unusual case of coccidioidomycosis presenting with skin lesions. (18806494)
2008
25
Coccidioidomycosis in rheumatology patients: incidence and potential risk factors. (17363440)
2007
26
Disseminated coccidioidomycosis in pregnancy. (17425401)
2007
27
Coccidioidomycosis in persons infected with HIV-1. (17363429)
2007
28
Disseminated coccidioidomycosis in a captive Indochinese tiger (Panthera tigris corbetti) with chronic renal disease. (17315442)
2006
29
Holocene coccidioidomycosis: Valley Fever in early Holocene bison (Bison antiquus). (17256570)
2006
30
Coccidioidomycosis of the prostate: a determination of incidence, report of 4 cases, and treatment recommendations. (15936822)
2006
31
Climate factors influencing coccidioidomycosis seasonality and outbreaks. (15929890)
2005
32
Disseminated coccidioidomycosis with cutaneous lesions clinically mimicking mycosis fungoides. (16336534)
2005
33
Coccidioidomycosis in liver transplant recipients relocating to an endemic area. (15628738)
2004
34
A cluster of disseminated coccidioidomycosis cases at a US military hospital. (12834136)
2003
35
Coccidioidomycosis mimicking lung cancer. (14732800)
2003
36
Coccidioidomycosis in Przewalski's horses (Equus przewalskii). (15077708)
2003
37
Donor transfer of pulmonary coccidioidomycosis in lung transplantation. (11834038)
2002
38
Reversal of coccidioidal anergy in vitro by dendritic cells from patients with disseminated coccidioidomycosis. (12165528)
2002
39
Coccidioidomycosis: efficacy of new agents and future prospects. (11964886)
2001
40
Serologic studies in coccidioidomycosis. (11740825)
2001
41
Primary pulmonary coccidioidomycosis. (11740823)
2001
42
Coccidioidomycosis complicating solid organ transplantation. (11740826)
2001
43
Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice. (11292702)
2001
44
Coccidioidomycosis in New York State. (10653565)
2000
45
Outbreak of coccidioidomycosis in Washington state residents returning from Mexico. (10619734)
2000
46
Coccidioidomycosis: a regional disease of national importance. Rethinking approaches for control. (10068388)
1999
47
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
48
Disseminated coccidioidomycosis diagnosed by culture of a central venous catheter tip. (8824997)
1996
49
Coccidioidomycosis: the other great imitator. (7555099)
1995
50
Coccidioidomycosis with necrotizing granulomatous conjunctivitis. (7842715)
1994

Variations for Coccidioidomycosis

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Expression for genes affiliated with Coccidioidomycosis

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Search GEO for disease gene expression data for Coccidioidomycosis.

Pathways for genes affiliated with Coccidioidomycosis

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Pathways related to Coccidioidomycosis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MBL2, IL10
2
Show member pathways
9.5IFNGR1, IFNG
39.5IL10, TLR4
49.4STAT1, IFNG
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.4IFNG, STAT1
6
Show member pathways
IL-2 Signaling pathway36
9.4IFNG, STAT1
79.4IFNG, TLR4
8
Show member pathways
9.3IL10, IFNG
99.3IFNG, IL10
109.3IFNG, IL10
119.3IL10, IFNG
129.3IFNG, IL10
139.3CLEC7A, MBL2, TLR4
14
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.3STAT1, CLEC7A, TLR4
159.1STAT1, IFNG, IFNGR1
169.1IFNGR1, STAT1, IFNG
17
Show member pathways
9.1IFNGR1, STAT1, IFNG
18
Show member pathways
9.1IFNGR1, STAT1, IFNG
199.1IFNG, IFNGR1, STAT1
20
Show member pathways
IFN-gamma pathway36
9.1IFNG, IFNGR1, STAT1
21
Show member pathways
9.1IFNGR1, IFNG, TLR4
229.1IFNG, IFNGR1, TLR4
23
Show member pathways
9.0IL10, IFNG, IFNGR1
24
Show member pathways
9.0IFNG, STAT1, TLR4
25
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.9STAT1, IFNG, IL10
268.9IL10, TLR4, IFNG
278.9TLR4, IL10, IFNG
28
Show member pathways
8.7STAT1, IFNGR1, TLR4, IFNG
298.7TLR4, IFNG, IFNGR1, STAT1
30
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.7IFNG, TLR4, IFNGR1, STAT1
31
Show member pathways
Immune response MIF in innate immunity response59
8.7STAT1, TLR4, IFNGR1, IFNG
32
Show member pathways
8.7IFNG, IFNGR1, STAT1, TLR4
33
Show member pathways
Type III interferon signaling36
8.6IL10, STAT1, IFNGR1, IFNG
34
Show member pathways
8.6STAT1, IFNG, IFNGR1, IL10
35
Show member pathways
8.6TLR4, IFNGR1, IL10, IFNG
36
Show member pathways
IL27-mediated signaling events36
8.1IFNG, STAT1, TLR4, IL10, IFNGR1
37
Show member pathways
8.1TLR4, STAT1, IFNGR1, IL10, IFNG
38
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.1TLR4, STAT1, IFNGR1, IFNG, IL10
397.8CLEC7A, IL10, IFNG, IFNGR1, STAT1, TLR4

Compounds for genes affiliated with Coccidioidomycosis

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Compounds related to Coccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
11-methyltryptophan449.7IFNG, TLR4
2zymosan449.7MBL2, CLEC7A, TLR4
3glucuronoxylomannan449.7TLR4, IL10
4betaseron449.6IFNG, IL10
5mannan449.5TLR4, MBL3P, MBL2
6lipoteichoic acid449.5TLR4, IL10, MBL2
7peptidoglycan44 2810.5MBL2, IL10, TLR4
8interferon gamma449.4IL10, IFNG
9anti-fungal449.4TLR4, MBL2, IFNG
10alpha-galactosylceramide449.3IL10, IFNG
11indoleamine449.3IFNG, STAT1, IL10
12echinacea449.3IL10, CD69
13neopterin449.3MBL2, IFNG, IL10
14il 10449.2TLR4, IFNG, IL10
15infliximab44 50 1111.2IL10, IFNG, TLR4
1615-deoxy-delta-12,14-prostaglandin j2449.2IL10, STAT1, IFNG
17ccl344 2810.2IL10, IFNG, TLR4
18vitamin d449.0STAT1, TLR4, IL10, MBL2
19prednisolone44 28 1111.0MBL2, IL10, IFNG
20n-acetylglucosamine449.0CD69, MBL2, MBL3P
21ribavirin44 50 1111.0STAT1, IFNG, IL10, MBL2
22polymyxin b448.9MBL2, IL10, IFNG, TLR4
23imiquimod44 60 28 1111.9STAT1, IL10, IFNG, TLR4
24polyinosinic-polycytidylic acid448.9IFNG, IL10, TLR4, STAT1
252,5-oligoadenylate448.9IFNG, IL10, STAT1, TLR4
26ifn-alpha448.9IL10, IFNG, TLR4, STAT1
27endotoxin448.9TLR4, STAT1, IFNG, IL10
28calcitriol44 60 24 1111.8IL10, IFNG, STAT1, TLR4
29sb 20358044 609.8TLR4, IL10, STAT1, IFNG
30carbohydrates448.7MBL2, TLR4, CD69
31polysaccharide448.6TLR4, CD69, MBL3P, MBL2
32herbimycin a44 609.6STAT1, CD69, IFNG
33poly(i-c)448.6CD69, TLR4, STAT1, IFNG
34tuberculin448.6IFNG, IL10, CD69, MBL2
35con a448.6CD69, IL10, MBL2, IFNG
36simvastatin44 50 60 28 24 1113.6IFNG, TLR4, IL10
37ly294002448.5CD69, TLR4, STAT1, IL10
38rantes448.5IFNG, IL10, MBL2, TLR4, STAT1
39allergens448.5IFNG, TLR4, CD69, IL10
40vegf448.5TLR4, MBL2, IL10, IFNG, STAT1
41tacrolimus44 50 1110.4IFNG, TLR4, IL10, CD69
42actinomycin d448.4CD69, STAT1, TLR4, IFNG
43mannose448.4CLEC7A, MBL2, MBL3P, CD69, TLR4
44genistein44 28 60 1 24 1113.4CD69, TLR4, IFNG, STAT1
45cyclosporin a44 28 6010.1IL10, IFNG, TLR4, STAT1, CD69
46pge2448.1IL10, IFNG, CD69, STAT1, TLR4
47tyrosine448.0CD69, MBL2, IFNGR1, CLEC7A, TLR4, STAT1
48cycloheximide448.0TLR4, IL10, IFNG, STAT1, CD69
49nitric oxide44 24 119.7IFNG, TLR4, STAT1, IL10, MBL2, CD69
50dexamethasone44 50 28 1110.4CLEC7A, MBL2, IL10, IFNG, CD69, STAT1

GO Terms for genes affiliated with Coccidioidomycosis

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Cellular components related to Coccidioidomycosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.2CD69, IFNG, CLEC7A, TLR4

Biological processes related to Coccidioidomycosis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phagocytosisGO:005076610.0CLEC7A, MBL2
2negative regulation of metanephric nephron tubule epithelial cell differentiationGO:00723089.8IFNG, STAT1
3defense response to protozoanGO:00428329.8CLEC7A, IFNG
4negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00033409.8IFNG, STAT1
5negative regulation of interleukin-6 productionGO:00327159.7TLR4, IL10
6positive regulation of interleukin-12 biosynthetic processGO:00450849.7TLR4, IFNG
7lipopolysaccharide-mediated signaling pathwayGO:00316639.7TLR4, STAT1
8negative regulation of interleukin-17 productionGO:00327009.7IFNG, TLR4
9negative regulation of interferon-gamma productionGO:00326899.6IL10, TLR4
10positive regulation of interleukin-12 productionGO:00327359.5IFNG, TLR4
11negative regulation of tumor necrosis factor productionGO:00327209.5TLR4, IL10
12regulation of interferon-gamma-mediated signaling pathwayGO:00603349.5STAT1, IFNG, IFNGR1
13interferon-gamma-mediated signaling pathwayGO:00603339.4IFNG, STAT1, IFNGR1
14positive regulation of tumor necrosis factor productionGO:00327609.4TLR4, CLEC7A, IFNG
15negative regulation of growth of symbiont in hostGO:00441309.3IL10, IFNG, MBL2
16cytokine-mediated signaling pathwayGO:00192219.3IFNG, IFNGR1, STAT1
17positive regulation of nitric oxide biosynthetic processGO:00454299.3TLR4, IFNG
18positive regulation of MHC class II biosynthetic processGO:00453489.2TLR4, IL10, IFNG
19cellular response to lipopolysaccharideGO:00712229.2IFNG, IL10, TLR4
20positive regulation of mesenchymal cell proliferationGO:00020539.1IFNG, STAT1
21response to drugGO:00424938.9IL10, STAT1, IFNG
22defense response to bacteriumGO:00427428.8MBL2, IL10, IFNG, TLR4
23positive regulation of transcription from RNA polymerase II promoterGO:00459448.7TLR4, IFNG, IL10, STAT1

Sources for Coccidioidomycosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet