MCID: CCC001
MIFTS: 63

Coccidioidomycosis malady

Rare diseases, Infectious diseases categories

Summaries for Coccidioidomycosis

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MedlinePlus:32 Valley fever is a disease caused by a fungus (or mold) called coccidioides. the fungi live in the soil of dry areas like the southwestern u.s. you get it from inhaling the spores of the fungus. the infection cannot spread from person to person. anyone can get valley fever. but it's most common among older adults, especially those 60 and older. people who have recently moved to an area where it occurs are at highest risk for infection. other people at higher risk include workers in jobs that expose them to soil dust. these include construction workers, agricultural workers, and military forces doing field training. african americans and asians women in their third trimester of pregnancy people with weak immune systems valley fever is often mild, with no symptoms. if you have symptoms, they may include a flu-like illness, with fever, cough, headache, rash, and muscle aches. most people get better within several weeks or months. a small number of people may develop a chronic lung or widespread infection. valley fever is diagnosed by testing your blood, other body fluids, or tissues. many people with the acute infection get better without treatment. in some cases, doctors may prescribe antifungal drugs for acute infections. severe infections require antifungal drugs. centers for disease control and prevention

MalaCards based summary: Coccidioidomycosis, also known as valley fever, is related to meningitis and candidiasis, and has symptoms including conjunctivitis, arthritis and chest pain. An important gene associated with Coccidioidomycosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Staphylococcus aureus infection and Cellular Transformation by HTLV1. The drugs fluconazole and ketoconazole and the compounds 1-methyltryptophan and zymosan have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology:9 A primary systemic mycosis that results in systemic fungal infection, has material basis in coccidioides immitis, transmitted by airborne spores and has symptom conjunctivitis, has symptom arthritis, has symptom chest pain and results in formation of skin nodules.

CDC:3 Valley fever, also called coccidioidomycosis, is an infection caused by the fungus Coccidioides. The fungus is known to live in the soil in the southwestern United States and parts of Mexico and Central and South America. The fungus was also recently found in south-central Washington. People can get valley fever by breathing in the microscopic fungal spores from the air, although most people who breathe in the spores don’t get sick. Usually, people who get sick with valley fever will get better on their own within weeks to months, but some people will need antifungal medication. Certain groups of people are at higher risk for becoming severely ill. It’s difficult to prevent exposure to Coccidioides in areas where it’s common in the environment, but people who are at higher risk for severe valley fever should try to avoid breathing in large amounts of dust if they’re in these areas.  

Wikipedia:63 Coccidioidomycosis (/k?k?s?di??do?ma??ko?s?s/, kok-sid-ee-oy-doh-my-KOH-sis), commonly known as cocci,... more...

Aliases & Classifications for Coccidioidomycosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Coccidioidomycosis, Aliases & Descriptions:

Name: Coccidioidomycosis 9 41 11 43 47 3 60
Valley Fever 41 47 32 3
Primary Extrapulmonary Coccidioidomycosis 9 60
Coccidiosis 41 60
Primary Pulmonary Coccidioidomycosis 60
Coccidioides Immitis Infection 41
San Joaquin Valley Fever 47
 
Coccidioides Infection 47
Enteric Coccidiosis 60
California Disease 47
San Joaquin Fever 41
Desert Rheumatism 47
Desert Fever 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

47
coccidioidomycosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:13450
MeSH33 D003047
ICD9CM27 114.9, 114
NCIt38 C84642
Orphanet47 228123
MESH via Orphanet34 D003047
ICD10 via Orphanet26 B38.0, B38.1, B38.2 B38.3, B38.4, B38.7, B38.8, B38.9, more
UMLS via Orphanet61 C0009186
ICD1025 B38, B38.9

Related Diseases for Coccidioidomycosis

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Diseases related to Coccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.1MBL2
2candidiasis30.5IFNG
3pneumonia30.1IL10, TLR4, MBL2
4hiv-130.1CD69, STAT1, TLR4
5uveitis30.0IFNG, CD69, IL10
6lepromatous leprosy30.0IL10, IFNG
7lupus nephritis29.9MBL2, IL10
8influenza29.7STAT1, MBL3P, IFNG, CD69, MBL2
9eosinophilia29.7STAT1, MBL2, IL10, CD69, IFNG
10leukemia29.4MBL2, IFNG, STAT1, TLR4
11atopic dermatitis29.4IFNG, IL10, CD69, TLR4
12tuberculosis28.6STAT1, CLEC7A, MBL2, TLR4, IL10, IFNG
13rift valley fever11.5
14coccidiosis11.3
15hemorrhagic fever10.5
16encephalitis10.5
17mycobacterium avium complex disease10.5IFNGR1
18crimean-congo hemorrhagic fever10.4
19histoplasmosis10.4
20thyroiditis10.4MBL2
21blastomycosis10.4
22filariasis10.4TLR4
23cryptosporidiosis10.3
24atypical mycobacteriosis, familial10.3IFNGR1, STAT1
25toxic shock syndrome10.2CD69, IFNG
26west nile virus10.2
27west nile fever10.2
28chikungunya10.2
29brucellosis10.2
30neurologic diseases10.2
31viral hemorrhagic fever10.2
32peritonitis10.2
33prostatitis10.2
34neisseria meningitidis infection10.2MBL2, TLR4
35hypercalcemia10.2
36cerebritis10.2
37sarcocystosis10.1
38diarrhea10.1
39synovitis10.1CD69, STAT1
40pulmonary eosinophilia10.1
41skin disease10.1
42newcastle disease10.1
43venezuelan equine encephalitis10.1
44lassa fever10.1
45japanese encephalitis10.1
46viral encephalitis10.1
47hepatorenal syndrome10.1
48yellow fever10.1
49hepatitis a10.1
50hydranencephaly10.1

Graphical network of the top 20 diseases related to Coccidioidomycosis:



Diseases related to coccidioidomycosis

Symptoms for Coccidioidomycosis

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Symptoms:

 9
  • conjunctivitis
  • arthritis
  • chest pain

Drugs & Therapeutics for Coccidioidomycosis

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Drug clinical trials:

Search ClinicalTrials for Coccidioidomycosis

Search NIH Clinical Center for Coccidioidomycosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Coccidioidomycosis

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Anatomical Context for Coccidioidomycosis

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MalaCards organs/tissues related to Coccidioidomycosis:

31
Lung, Testes, Skin, Liver, Brain, Prostate, Whole blood, T cells, Bone, Lymph node, Heart, Kidney, Pancreas, Testis, B cells, Tongue, Neutrophil

Animal Models for Coccidioidomycosis or affiliated genes

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Publications for Coccidioidomycosis

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Articles related to Coccidioidomycosis:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Coccidioidomycosis and other systemic mycoses of marine mammals stranding along the central california, USA coast: 1998-2012. (25647598)
2015
2
Empyema necessitatis: unique presentation in a coccidioidomycosis case. (25876208)
2015
3
Distance from construction site and risk for coccidioidomycosis, Arizona, USA. (25148473)
2014
4
A newly diagnosed Wegener's disease as the underlying cause for a disseminated coccidioidomycosis. (24156233)
2013
5
Routine CSF analysis in coccidioidomycosis is not required. (23717579)
2013
6
Rare manifestations of coccidioidomycosis. (24015425)
2013
7
Coccidioidomycosis: adenosine deaminase levels, serologic parameters, culture results, and polymerase chain reaction testing in pleural fluid. (23187746)
2013
8
Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. (23488972)
2013
9
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. (23541320)
2013
10
Biochemical characterization of an in-house Coccidioides antigen: perspectives for the immunodiagnosis of coccidioidomycosis. (22743589)
2012
11
A reformulated spherule-derived coccidioidin (Spherusol) to detect delayed-type hypersensitivity in coccidioidomycosis. (22669545)
2012
12
Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related peptide is characteristic of granulomatous inflammation. (22670039)
2012
13
Multiple lung abscesses caused by Actinomyces graevenitzii mimicking acute pulmonary coccidioidomycosis. (22760049)
2012
14
Serum (1->3)-I^-D-glucan measurement in coccidioidomycosis. (22692738)
2012
15
The utility of fine needle aspiration for diagnosis of extrapulmonary coccidioidomycosis: a case report and discussion. (21562136)
2011
16
Subclinical dissemination of coccidioidomycosis in a liver transplant recipient. (21744045)
2011
17
Reactivation of coccidioidomycosis despite antifungal prophylaxis in solid organ transplant recipients. (21516063)
2011
18
Pulmonary coccidioidomycosis. (22167403)
2011
19
Clinical and pathologic characteristics of disseminated cutaneous coccidioidomycosis. (20398813)
2010
20
Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States. (19934792)
2010
21
Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency. (19681704)
2009
22
Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. (18781884)
2008
23
Acute pulmonary coccidioidomycosis: CT findings from 15 patients. (18508875)
2008
24
An unusual case of coccidioidomycosis presenting with skin lesions. (18806494)
2008
25
Coccidioidomycosis in rheumatology patients: incidence and potential risk factors. (17363440)
2007
26
Disseminated coccidioidomycosis in pregnancy. (17425401)
2007
27
Coccidioidomycosis in persons infected with HIV-1. (17363429)
2007
28
Disseminated coccidioidomycosis in a captive Indochinese tiger (Panthera tigris corbetti) with chronic renal disease. (17315442)
2006
29
Holocene coccidioidomycosis: Valley Fever in early Holocene bison (Bison antiquus). (17256570)
2006
30
Coccidioidomycosis of the prostate: a determination of incidence, report of 4 cases, and treatment recommendations. (15936822)
2006
31
Climate factors influencing coccidioidomycosis seasonality and outbreaks. (15929890)
2005
32
Disseminated coccidioidomycosis with cutaneous lesions clinically mimicking mycosis fungoides. (16336534)
2005
33
Coccidioidomycosis in liver transplant recipients relocating to an endemic area. (15628738)
2004
34
A cluster of disseminated coccidioidomycosis cases at a US military hospital. (12834136)
2003
35
Coccidioidomycosis mimicking lung cancer. (14732800)
2003
36
Coccidioidomycosis in Przewalski's horses (Equus przewalskii). (15077708)
2003
37
Donor transfer of pulmonary coccidioidomycosis in lung transplantation. (11834038)
2002
38
Reversal of coccidioidal anergy in vitro by dendritic cells from patients with disseminated coccidioidomycosis. (12165528)
2002
39
Coccidioidomycosis: efficacy of new agents and future prospects. (11964886)
2001
40
Serologic studies in coccidioidomycosis. (11740825)
2001
41
Primary pulmonary coccidioidomycosis. (11740823)
2001
42
Coccidioidomycosis complicating solid organ transplantation. (11740826)
2001
43
Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice. (11292702)
2001
44
Coccidioidomycosis in New York State. (10653565)
2000
45
Outbreak of coccidioidomycosis in Washington state residents returning from Mexico. (10619734)
2000
46
Coccidioidomycosis: a regional disease of national importance. Rethinking approaches for control. (10068388)
1999
47
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
48
Disseminated coccidioidomycosis diagnosed by culture of a central venous catheter tip. (8824997)
1996
49
Coccidioidomycosis: the other great imitator. (7555099)
1995
50
Coccidioidomycosis with necrotizing granulomatous conjunctivitis. (7842715)
1994

Variations for Coccidioidomycosis

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Expression for genes affiliated with Coccidioidomycosis

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Search GEO for disease gene expression data for Coccidioidomycosis.

Pathways for genes affiliated with Coccidioidomycosis

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Pathways related to Coccidioidomycosis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MBL2, IL10
2
Show member pathways
9.5IFNGR1, IFNG
39.5IL10, TLR4
4
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.4IFNG, STAT1
5
Show member pathways
IL-2 Signaling pathway36
9.4IFNG, STAT1
69.4IFNG, STAT1
79.4TLR4, IFNG
8
Show member pathways
9.3IL10, IFNG
99.3IL10, IFNG
109.3IFNG, IL10
119.3IL10, IFNG
129.3IL10, IFNG
139.3MBL2, CLEC7A, TLR4
14
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.3TLR4, CLEC7A, STAT1
15
Show member pathways
9.1STAT1, IFNGR1, IFNG
169.1STAT1, IFNGR1, IFNG
179.1IFNG, IFNGR1, STAT1
18
Show member pathways
9.1IFNG, IFNGR1, STAT1
19
Show member pathways
IFN-gamma pathway36
9.1IFNG, IFNGR1, STAT1
209.1IFNG, IFNGR1, STAT1
219.1TLR4, IFNGR1, IFNG
22
Show member pathways
9.1IFNG, IFNGR1, TLR4
23
Show member pathways
9.0IFNGR1, IFNG, IL10
24
Show member pathways
9.0IFNG, STAT1, TLR4
25
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.9IL10, IFNG, STAT1
268.9IL10, IFNG, TLR4
278.9TLR4, IFNG, IL10
28
Show member pathways
8.7TLR4, STAT1, IFNGR1, IFNG
298.7TLR4, STAT1, IFNGR1, IFNG
30
Show member pathways
8.7TLR4, STAT1, IFNGR1, IFNG
31
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.7TLR4, STAT1, IFNGR1, IFNG
32
Show member pathways
Immune response MIF in innate immunity response58
8.7IFNG, IFNGR1, STAT1, TLR4
33
Show member pathways
Type III interferon signaling36
8.6IL10, IFNG, IFNGR1, STAT1
34
Show member pathways
8.6IL10, IFNG, IFNGR1, STAT1
35
Show member pathways
8.6IL10, IFNG, IFNGR1, TLR4
36
Show member pathways
IL27-mediated signaling events36
8.1TLR4, STAT1, IFNGR1, IFNG, IL10
37
Show member pathways
8.1TLR4, STAT1, IFNGR1, IFNG, IL10
38
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.1IL10, IFNG, IFNGR1, STAT1, TLR4
397.8IL10, IFNG, IFNGR1, STAT1, CLEC7A, TLR4

Compounds for genes affiliated with Coccidioidomycosis

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Compounds related to Coccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
11-methyltryptophan439.7IFNG, TLR4
2zymosan439.7MBL2, CLEC7A, TLR4
3glucuronoxylomannan439.7TLR4, IL10
4betaseron439.6IFNG, IL10
5mannan439.5TLR4, MBL3P, MBL2
6lipoteichoic acid439.5TLR4, IL10, MBL2
7peptidoglycan43 2810.5MBL2, IL10, TLR4
8interferon gamma439.4IL10, IFNG
9anti-fungal439.4TLR4, MBL2, IFNG
10alpha-galactosylceramide439.3IL10, IFNG
11indoleamine439.3IFNG, STAT1, IL10
12echinacea439.3IL10, CD69
13neopterin439.3MBL2, IFNG, IL10
14il 10439.2TLR4, IFNG, IL10
15infliximab43 49 1211.2IL10, IFNG, TLR4
1615-deoxy-delta-12,14-prostaglandin j2439.2IL10, STAT1, IFNG
17ccl343 2810.2IL10, IFNG, TLR4
18vitamin d439.0STAT1, TLR4, IL10, MBL2
19prednisolone43 28 1211.0MBL2, IL10, IFNG
20n-acetylglucosamine439.0CD69, MBL2, MBL3P
21ribavirin43 49 1211.0STAT1, IFNG, IL10, MBL2
22polymyxin b438.9MBL2, IL10, IFNG, TLR4
23imiquimod43 59 28 1211.9STAT1, IL10, IFNG, TLR4
24polyinosinic-polycytidylic acid438.9IFNG, IL10, TLR4, STAT1
252,5-oligoadenylate438.9IFNG, IL10, STAT1, TLR4
26ifn-alpha438.9IL10, IFNG, TLR4, STAT1
27endotoxin438.9TLR4, STAT1, IFNG, IL10
28calcitriol43 59 24 1211.8IL10, IFNG, STAT1, TLR4
29sb 20358043 599.8TLR4, IL10, STAT1, IFNG
30carbohydrates438.7MBL2, TLR4, CD69
31polysaccharide438.6TLR4, CD69, MBL3P, MBL2
32herbimycin a43 599.6STAT1, CD69, IFNG
33poly(i-c)438.6CD69, TLR4, STAT1, IFNG
34tuberculin438.6IFNG, IL10, CD69, MBL2
35con a438.6CD69, IL10, MBL2, IFNG
36simvastatin43 49 59 28 24 1213.6IFNG, TLR4, IL10
37ly294002438.5CD69, TLR4, STAT1, IL10
38rantes438.5IFNG, IL10, MBL2, TLR4, STAT1
39allergens438.5IFNG, TLR4, CD69, IL10
40vegf438.5TLR4, MBL2, IL10, IFNG, STAT1
41tacrolimus43 49 1210.4IFNG, TLR4, IL10, CD69
42actinomycin d438.4CD69, STAT1, TLR4, IFNG
43mannose438.4CLEC7A, MBL2, MBL3P, CD69, TLR4
44genistein43 28 59 2 24 1213.4CD69, TLR4, IFNG, STAT1
45cyclosporin a43 28 5910.1IL10, IFNG, TLR4, STAT1, CD69
46pge2438.1IL10, IFNG, CD69, STAT1, TLR4
47tyrosine438.0CD69, MBL2, IFNGR1, CLEC7A, TLR4, STAT1
48cycloheximide438.0TLR4, IL10, IFNG, STAT1, CD69
49nitric oxide43 24 129.7IFNG, TLR4, STAT1, IL10, MBL2, CD69
50dexamethasone43 49 28 1210.4CLEC7A, MBL2, IL10, IFNG, CD69, STAT1

GO Terms for genes affiliated with Coccidioidomycosis

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Cellular components related to Coccidioidomycosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.2CD69, IFNG, CLEC7A, TLR4

Biological processes related to Coccidioidomycosis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phagocytosisGO:005076610.0MBL2, CLEC7A
2negative regulation of metanephric nephron tubule epithelial cell differentiationGO:00723089.8IFNG, STAT1
3defense response to protozoanGO:00428329.8IFNG, CLEC7A
4negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00033409.8IFNG, STAT1
5negative regulation of interleukin-6 productionGO:00327159.7IL10, TLR4
6positive regulation of interleukin-12 biosynthetic processGO:00450849.7IFNG, TLR4
7lipopolysaccharide-mediated signaling pathwayGO:00316639.7STAT1, TLR4
8negative regulation of interleukin-17 productionGO:00327009.7TLR4, IFNG
9negative regulation of interferon-gamma productionGO:00326899.6IL10, TLR4
10positive regulation of interleukin-12 productionGO:00327359.5TLR4, IFNG
11regulation of interferon-gamma-mediated signaling pathwayGO:00603349.5STAT1, IFNGR1, IFNG
12interferon-gamma-mediated signaling pathwayGO:00603339.4STAT1, IFNGR1, IFNG
13positive regulation of nitric oxide biosynthetic processGO:00454299.4TLR4, IFNG
14negative regulation of tumor necrosis factor productionGO:00327209.4TLR4, IL10
15positive regulation of tumor necrosis factor productionGO:00327609.4TLR4, CLEC7A, IFNG
16negative regulation of growth of symbiont in hostGO:00441309.3MBL2, IL10, IFNG
17cytokine-mediated signaling pathwayGO:00192219.3IFNG, IFNGR1, STAT1
18positive regulation of MHC class II biosynthetic processGO:00453489.2IL10, IFNG, TLR4
19cellular response to lipopolysaccharideGO:00712229.2IL10, IFNG, TLR4
20positive regulation of mesenchymal cell proliferationGO:00020539.1IFNG, STAT1
21response to drugGO:00424938.9IL10, IFNG, STAT1
22defense response to bacteriumGO:00427428.8MBL2, IL10, IFNG, TLR4
23positive regulation of transcription from RNA polymerase II promoterGO:00459448.7TLR4, STAT1, IFNG, IL10

Products for genes affiliated with Coccidioidomycosis

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Sources for Coccidioidomycosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet