MCID: CLC008
MIFTS: 26

Colchicine Resistance malady

Summaries for Colchicine Resistance

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46OMIM, 32MalaCards
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MalaCards: Colchicine Resistance is related to familial mediterranean fever and cystic fibrosis. An important gene associated with Colchicine Resistance is ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1), and among its related pathways are Irinotecan Pathway, Pharmacokinetics and Doxorubicin Pathway, Pharmacokinetics. The compounds tariquidar and gf 120918 have been mentioned in the context of this disorder. Related mouse phenotype liver/biliary system.

Description from OMIM:46 120080

Aliases & Classifications for Colchicine Resistance

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46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

colchicine resistance 46 44 60


Related Diseases for Colchicine Resistance

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17GeneCards, 18GeneDecks
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Diseases related to Colchicine Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1familial mediterranean fever30.6MEFV
2cystic fibrosis13.3DNAH8, IL1R1, ABCB1, ABCB11, ABCC1
3intrahepatic cholestasis13.3DNAH8, ABCB11, ABCC1
4burkitt's lymphoma13.3IL1R1, ABCB1, ABCB11, ABCC1
5cholelithiasis13.3ABCB11
6adenocarcinoma13.3DNAH8, ABCB1, ABCB11, ABCC1
7breast cancer13.3ABCC1, ABCB11, ABCB1, DNAH8
8cholestasis13.3ABCB11, ABCC1
9colon adenocarcinoma13.3ABCC1, ABCB1
10colon cancer13.3ABCC1, ABCB1
11epilepsy syndrome13.3ABCC1, ABCB11, ABCB1, DNAH8
12epithelioid sarcoma13.3ABCC1, ABCB1
13kidney cancer13.3ABCC1, ABCB1, IL1R1
14leukemia13.3ABCC1, ABCB11, ABCB1, IL1R1, DNAH8
15liver cirrhosis13.3DNAH8, ABCB11, ABCC1
16lung small cell carcinoma13.3ABCC1, ABCB11, ABCB1
17malignant glioma13.3ABCB1, ABCC1
18melanoma13.3ABCC1, ABCB11, DNAH8, MEFV
19monocytic leukemia13.3IL1R1, ABCB1, ABCC1
20myeloid leukemia13.3ABCC1, ABCB1
21non-small cell lung carcinoma13.3ABCC1, ABCB1, DNAH8
22osteosarcoma13.3ABCC1, ABCB11, ABCB1
23ovarian cancer13.3ABCC1, ABCB11, ABCB1
24rhabdomyosarcoma13.3DNAH8, ABCB1, ABCC1
25rheumatoid arthritis13.3ABCC1, IL1R1, DNAH8, MEFV
26sarcoma13.3IL1R1, ABCB1, ABCB11, ABCC1
27acute myeloid leukemia, adult13.3ABCC1, ABCB1
28acute lymphoblastic leukemia, childhood13.3ABCC1, ABCB1
29myelodysplastic syndromes13.3ABCB1, ABCB11
30leukemia, acute nonlymphocytic13.3ABCC1, ABCB1
31amyloidosis10.0
32prostate cancer10.0IL1R1
33hepatoblastoma10.0ABCB1
34malaria10.0DNAH8
35lung cancer10.0ABCB1
36glomerulonephritis10.0IL1R1
37peritonitis10.0MEFV
38hypertension10.0DNAH8
39vasculitis10.0MEFV
40pyoderma gangrenosum10.0MEFV
41atherosclerosis10.0IL1R1, DNAH8
42multiple sclerosis10.0DNAH8, IL1R1
43familial cold autoinflammatory syndrome10.0IL1R1, MEFV
44chronic infantile neurological cutaneous articular syndrome10.0MEFV, IL1R1
45muckle-wells syndrome10.0IL1R1, MEFV
46arthritis10.0IL1R1, MEFV
47rheumatic disease10.0IL1R1, MEFV
48iga glomerulonephritis10.0MEFV, IL1R1

Graphical network of the top 20 diseases related to Colchicine Resistance:



Diseases related to colchicine resistance

Clinical Features for Colchicine Resistance

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46OMIM
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Clinical features from OMIM:

120080

Drugs & Therapeutics for Colchicine Resistance

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colchicine Resistance

Drug clinical trials:

Search ClinicalTrials for Colchicine Resistance

Search NIH Clinical Center for Colchicine Resistance

Search CenterWatch for Colchicine Resistance

Genetic Tests for Colchicine Resistance

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Anatomical Context for Colchicine Resistance

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Animal Models for Colchicine Resistance or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colchicine Resistance:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ABCB1, IL1R1, MEFV

Publications for Colchicine Resistance

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Genetic Variations for Colchicine Resistance

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Expression for genes affiliated with Colchicine Resistance

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colchicine Resistance

Search GEO for disease gene expression data for Colchicine Resistance.

Pathways for genes affiliated with Colchicine Resistance

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Colchicine Resistance

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Colchicine Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tariquidar4410.4ABCB1
2gf 1209184410.4ABCB1
3ly3359794410.4ABCB1
4psc-8334410.4ABCB1
5idarubicin44 49 1112.4ABCB1
6cyclosporine49 1111.3ABCB1
7Glyburide1110.3ABCB1
8Taurocholic Acid11 2411.3ABCB1
9rifampin49 1111.3ABCB1
10nelfinavir44 49 1112.3ABCB1
11saquinavir44 1111.3ABCB1
12taurocholate4410.3ABCB1
13bodipy-verapamil4410.3ABCB1
14idarubicinol4410.3ABCB1
15biricodar4410.3ABCB1
16sb 304410.3ABCB1
17ritonavir44 49 1112.2ABCB1
18cholic acid44 28 11 2413.2ABCB1
19daunoxome4410.2ABCB1
20deoxycorticosterone acetate4410.2ABCB1
21ortataxel4410.1ABCB1
22annamycin4410.1ABCB1
23mr204410.1ABCB1
24erythromycin44 49 2 1113.0ABCB1
25fumitremorgin c4410.0DNAH8
26rhodamine 12344 4910.9ABCB1, DNAH8
27tetramethylrosamine449.9DNAH8, ABCB1
28azidopine449.9ABCB1, DNAH8
29(125i)iodoarylazidoprazosin449.9ABCB1, DNAH8
30quinidine44 28 49 1112.9ABCB1, DNAH8
31digoxin44 49 59 11 2413.9DNAH8, ABCB1
32rifampicin44 28 5911.9DNAH8, ABCB1
33daunorubicin44 49 1111.9ABCB1, DNAH8
34vinblastine44 49 1111.8DNAH8, ABCB1
35flupenthixol44 49 1111.8ABCB1, DNAH8
368-azido-atp449.8ABCB1, DNAH8
37verapamil44 49 28 11 2413.8ABCB1, DNAH8
388-azido-adp449.8DNAH8, ABCB1
39colchicine59 44 2 28 1113.7ABCB1, MEFV
40probenecid44 28 59 49 1113.7DNAH8, ABCB1
41mitoxantrone44 49 1111.7DNAH8, ABCB1
42doxorubicin44 49 1111.4DNAH8, ABCB1
43cimetidine44 28 1111.4ABCB1, IL1R1
44diclofenac44 28 49 1112.4ABCB1, IL1R1
45epinephrine44 11 2411.0ABCB1, IL1R1, DNAH8
46etoposide44 49 59 1112.0ABCB1, DNAH8, IL1R1
47ibuprofen44 28 49 11 2413.0IL1R1, ABCB1
48cyclosporin a44 28 5911.0DNAH8, IL1R1, ABCB1
49indomethacin44 59 28 1111.9ABCB1, DNAH8, IL1R1
50actinomycin d448.8ABCB1, IL1R1

GO Terms for genes affiliated with Colchicine Resistance

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16Gene Ontology
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Cellular components related to Colchicine Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:0465819.7ABCB1
2membraneGO:0160209.1ABCB1, IL1R1

Biological processes related to Colchicine Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:05508510.0ABCB1
2transportGO:0068109.7ABCB1

Molecular functions related to Colchicine Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:0426269.9ABCB1
2transporter activityGO:0052159.7ABCB1
3ATP bindingGO:0055249.4ABCB1, DNAH8

Products for genes affiliated with Colchicine Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colchicine Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet