MCID: CLC008
MIFTS: 28

Colchicine Resistance malady

Summaries for Colchicine Resistance

Sources:
47OMIM, 33MalaCards
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MalaCards: Colchicine Resistance is related to familial mediterranean fever and cystic fibrosis. An important gene associated with Colchicine Resistance is ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1), and among its related pathways are Irinotecan Pathway, Pharmacokinetics and Doxorubicin Pathway, Pharmacokinetics. The compounds tariquidar and gf 120918 have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotype liver/biliary system.

Description from OMIM:47 120080

Aliases & Classifications for Colchicine Resistance

Sources:
47OMIM, 45Novoseek, 61UMLS
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Aliases & Descriptions:

colchicine resistance 47 45 61


Related Diseases for Colchicine Resistance

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Colchicine Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1familial mediterranean fever30.6MEFV
2cystic fibrosis13.3ABCC1, IL1R1, ABCB1, ABCB11, DNAH8
3intrahepatic cholestasis13.3ABCB11, ABCC1, DNAH8
4burkitt's lymphoma13.3ABCB1, IL1R1, ABCC1, ABCB11
5cholelithiasis13.3ABCB11
6adenocarcinoma13.3ABCB11, ABCB1, DNAH8, ABCC1
7breast cancer13.3DNAH8, ABCC1, ABCB11, ABCB1
8cholestasis13.3ABCB11, ABCC1
9colon adenocarcinoma13.3ABCC1, ABCB1
10colon cancer13.3ABCB1, ABCC1
11epilepsy syndrome13.3ABCC1, ABCB11, ABCB1, DNAH8
12epithelioid sarcoma13.3ABCC1, ABCB1
13kidney cancer13.3ABCB1, IL1R1, ABCC1
14leukemia13.3DNAH8, ABCB11, ABCB1, IL1R1, ABCC1
15liver cirrhosis13.3DNAH8, ABCB11, ABCC1
16lung small cell carcinoma13.3ABCB1, ABCB11, ABCC1
17malignant glioma13.3ABCB1, ABCC1
18melanoma13.3ABCC1, DNAH8, ABCB11, MEFV
19monocytic leukemia13.3ABCB1, ABCC1, IL1R1
20myeloid leukemia13.3ABCC1, ABCB1
21non-small cell lung carcinoma13.3ABCC1, ABCB1, DNAH8
22osteosarcoma13.3ABCB1, ABCB11, ABCC1
23ovarian cancer13.3ABCC1, ABCB11, ABCB1
24rhabdomyosarcoma13.3ABCC1, ABCB1, DNAH8
25rheumatoid arthritis13.3MEFV, DNAH8, IL1R1, ABCC1
26sarcoma13.3ABCC1, ABCB11, ABCB1, IL1R1
27acute myeloid leukemia, adult13.3ABCB1, ABCC1
28acute lymphoblastic leukemia, childhood13.3ABCC1, ABCB1
29myelodysplastic syndromes13.3ABCB1, ABCB11
30leukemia, acute nonlymphocytic13.3ABCB1, ABCC1
31amyloidosis10.0
32periodic fever, familial, autosomal dominant10.0
33periodic fever, familial10.0
34amyloidosis, renal10.0
35prostate cancer10.0IL1R1
36hepatoblastoma10.0ABCB1
37malaria10.0DNAH8
38lung cancer10.0ABCB1
39glomerulonephritis10.0IL1R1
40peritonitis10.0MEFV
41hypertension10.0DNAH8
42vasculitis10.0MEFV
43pyoderma gangrenosum10.0MEFV
44atherosclerosis10.0DNAH8, IL1R1
45multiple sclerosis10.0IL1R1, DNAH8
46familial cold autoinflammatory syndrome10.0IL1R1, MEFV
47chronic infantile neurological cutaneous articular syndrome10.0MEFV, IL1R1
48muckle-wells syndrome10.0MEFV, IL1R1
49arthritis10.0MEFV, IL1R1
50rheumatic disease10.0MEFV, IL1R1

Graphical network of the top 20 diseases related to Colchicine Resistance:



Diseases related to colchicine resistance

Clinical Features for Colchicine Resistance

Sources:
47OMIM
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Clinical features from OMIM:

120080

Drugs & Therapeutics for Colchicine Resistance

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colchicine Resistance

Drug clinical trials:

Search ClinicalTrials for Colchicine Resistance

Search NIH Clinical Center for Colchicine Resistance

Search CenterWatch for Colchicine Resistance

Genetic Tests for Colchicine Resistance

Anatomical Context for Colchicine Resistance

Sources:
33MalaCards
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MalaCards organs/tissues related to Colchicine Resistance:

33
Liver

Animal Models for Colchicine Resistance or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Colchicine Resistance:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ABCB1, IL1R1, MEFV

Publications for Colchicine Resistance

Sources:
51PubMed
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Articles related to Colchicine Resistance:

(show all 19)
idTitleAuthorsYear
1
Comparative analyses of the I^-tubulin gene and molecular modeling reveal molecular insight into the colchicine resistance in kinetoplastids organisms. (24083244)
2013
2
A severe autosomal-dominant periodic inflammatory disorder with renal AA amyloidosis and colchicine resistance associated to the MEFV H478Y variant in a Spanish kindred: an unusual familial Mediterranean fever phenotype or another MEFV-associated periodic inflammatory disorder? (14679589)
2004
3
Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo. (15388989)
2004
4
Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo. (12235361)
2002
5
P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. (11284688)
2001
6
Coordinated regulation of P-glycoprotein activity and cytochrome P-4501A induction in sublines of rat hepatoma McA RH7777 cells with different levels of colchicine resistance. (10367566)
1998
7
Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. (9699675)
1998
8
Colchicine-resistance and enhancement of P-glycoprotein activity after co-cultivation of drug-sensitive cells with multidrug resistant variants. (7742775)
1995
9
Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver. (7890890)
1994
10
Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. (1611154)
1992
11
Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein. (1976255)
1990
12
Expression of phenotypic traits following modulation of colchicine resistance in J774.2 cells. (3700481)
1986
13
Colchicine resistance in human cell lines. Pleiotropic phenotype and decreased membrane permeability. (7129432)
1982
14
Persistence of colchicine resistance in Ehrlich-LettrAc ascites tumors and cell strains. (7334053)
1981
15
Studies on a morphologically distinct colchicine-resistance variant of Entamoeba sp. (490433)
1979
16
Dominance of colchicine resistance in hybrid CHO cells. (566474)
1978
17
A conditional cell division mutant of Chlamydomonas reinhardii having an increased level of colchicine resistance. (964308)
1976
18
Colchicine resistance in mammalian cell lines. (165207)
1975
19
Nature of colchicine resistance in golden hamster. (13668535)
1959

Genetic Variations for Colchicine Resistance

Expression for genes affiliated with Colchicine Resistance

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colchicine Resistance

Search GEO for disease gene expression data for Colchicine Resistance.

Pathways for genes affiliated with Colchicine Resistance

Sources:
50PharmGKB, 38NCBI BioSystems Database, 30KEGG, 54Reactome
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Compounds for genes affiliated with Colchicine Resistance

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Colchicine Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tariquidar4510.4ABCB1
2gf 1209184510.4ABCB1
3ly3359794510.4ABCB1
4psc-8334510.4ABCB1
5idarubicin45 50 1112.4ABCB1
6cyclosporine50 1111.3ABCB1
7Glyburide1110.3ABCB1
8Taurocholic Acid11 2411.3ABCB1
9rifampin50 1111.3ABCB1
10nelfinavir45 50 1112.3ABCB1
11saquinavir45 1111.3ABCB1
12taurocholate4510.3ABCB1
13bodipy-verapamil4510.3ABCB1
14idarubicinol4510.3ABCB1
15biricodar4510.3ABCB1
16sb 304510.3ABCB1
17ritonavir45 50 1112.2ABCB1
18cholic acid45 29 11 2413.2ABCB1
19daunoxome4510.2ABCB1
20deoxycorticosterone acetate4510.2ABCB1
21ortataxel4510.1ABCB1
22annamycin4510.1ABCB1
23mr204510.1ABCB1
24erythromycin45 50 2 1113.0ABCB1
25fumitremorgin c4510.0DNAH8
26rhodamine 12345 5010.9ABCB1, DNAH8
27tetramethylrosamine459.9DNAH8, ABCB1
28azidopine459.9ABCB1, DNAH8
29(125i)iodoarylazidoprazosin459.9ABCB1, DNAH8
30quinidine45 29 50 1112.9ABCB1, DNAH8
31digoxin45 50 60 11 2413.9DNAH8, ABCB1
32rifampicin45 29 6011.9DNAH8, ABCB1
33daunorubicin45 50 1111.9ABCB1, DNAH8
34vinblastine45 50 1111.8DNAH8, ABCB1
35flupenthixol45 50 1111.8ABCB1, DNAH8
368-azido-atp459.8ABCB1, DNAH8
37verapamil45 50 29 11 2413.8ABCB1, DNAH8
388-azido-adp459.8DNAH8, ABCB1
39colchicine60 45 2 29 1113.7ABCB1, MEFV
40probenecid45 29 60 50 1113.7DNAH8, ABCB1
41mitoxantrone45 50 1111.7DNAH8, ABCB1
42doxorubicin45 50 1111.4DNAH8, ABCB1
43cimetidine45 29 1111.4ABCB1, IL1R1
44diclofenac45 29 50 1112.4ABCB1, IL1R1
45epinephrine45 11 2411.0ABCB1, IL1R1, DNAH8
46etoposide45 50 60 1112.0ABCB1, DNAH8, IL1R1
47ibuprofen45 29 50 11 2413.0IL1R1, ABCB1
48cyclosporin a45 29 6011.0DNAH8, IL1R1, ABCB1
49indomethacin45 60 29 1111.9ABCB1, DNAH8, IL1R1
50actinomycin d458.8ABCB1, IL1R1

GO Terms for genes affiliated with Colchicine Resistance

Sources:
16Gene Ontology
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Cellular components related to Colchicine Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:0465819.7ABCB1
2membraneGO:0160209.1ABCB1, IL1R1

Biological processes related to Colchicine Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:05508510.0ABCB1
2transportGO:0068109.7ABCB1

Molecular functions related to Colchicine Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:0426269.9ABCB1
2transporter activityGO:0052159.7ABCB1
3ATP bindingGO:0055249.4DNAH8, ABCB1

Products for genes affiliated with Colchicine Resistance

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colchicine Resistance

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet