CAD
MCID: CLD007
MIFTS: 44

Cold Agglutinin Disease (CAD) malady

Categories: Rare diseases, Blood diseases, Immune diseases

Aliases & Classifications for Cold Agglutinin Disease

Aliases & Descriptions for Cold Agglutinin Disease:

Name: Cold Agglutinin Disease 50 56
Chronic Cold Agglutinin Disease 56 69
Cad 50 56
Anemia, Hemolytic, Cold Antibody 50
Cold Antibody Hemolytic Anemia 50
Cold Hemagglutinin Disease 69
Cold Agglutinin Syndrome 56
Cold Antibody Disease 50
Cas 56

Characteristics:

Orphanet epidemiological data:

56
cold agglutinin disease
Inheritance: Multigenic/multifactorial; Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

Orphanet 56 ORPHA56425
ICD10 via Orphanet 34 D59.1

Summaries for Cold Agglutinin Disease

NIH Rare Diseases : 50 cold agglutinin disease is a rare type of autoimmune hemolytic anemia in which the body's immune system mistakenly attacks and destroys its own red blood cells. when affected people's blood is exposed to cold temperatures (32º to 50º f), certain proteins that normally attack bacteria (igm antibodies) attach themselves to red blood cells and bind them together into clumps (agglutination). this eventually causes red blood cells to be prematurely destroyed (hemolysis) leading to anemia and other associated signs and symptoms. cold agglutinin disease can be primary (unknown cause) or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers. treatment depends on many factors including the severity of the condition, the signs and symptoms present in each person, and the underlying cause. last updated: 5/26/2016

MalaCards based summary : Cold Agglutinin Disease, also known as chronic cold agglutinin disease, is related to neuropathy and lupus erythematosus, and has symptoms including arthralgia, fatigue and headache. An important gene associated with Cold Agglutinin Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Fludarabine and rituximab have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow.

Wikipedia : 71 Cold agglutinin disease is an autoimmune disease characterized by the presence of high concentrations of... more...

Related Diseases for Cold Agglutinin Disease

Diseases related to Cold Agglutinin Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
id Related Disease Score Top Affiliating Genes
1 neuropathy 29.9 CRP IL6
2 lupus erythematosus 29.6 CRP IL6
3 histiocytosis 29.5 CRP IL6
4 scott syndrome 11.2
5 gastric cancer 11.2
6 pancreatic cancer 11.2
7 esophageal cancer 11.1
8 warm antibody hemolytic anemia 11.0
9 lymphoma 10.3
10 cryoglobulinemia 10.1
11 cutaneous sclerosis 10.0 CRP IL6
12 shoulder impingement syndrome 10.0 CRP IL6
13 unilateral multicystic dysplastic kidney 10.0 CRP IL6
14 neutrophilia, hereditary 10.0 CRP IL6
15 swine influenza 10.0 CRP IL6
16 cardiac tuberculosis 10.0 CRP IL6
17 cataract, total congenital 10.0 CRP IL6
18 laryngotracheoesophageal cleft type 2 10.0 CRP IL6
19 gastric lymphoma 10.0 CRP IL6
20 leukemia 10.0
21 b-cell lymphomas 10.0
22 human immunodeficiency virus infectious disease 10.0 CRP IL6
23 secretory diarrhea myopathy and deafness 10.0 CRP IL6
24 hemangioma of spleen 10.0 CRP IL6
25 mixed eosinophil-basophil adenoma 10.0 CRP IL6
26 retinal degeneration 10.0 CRP IL6
27 joint disorders 10.0 CRP IL6
28 nodular nonsuppurative panniculitis 10.0 CRP IL6
29 toxic myocarditis 10.0 CRP IL6
30 cicatricial lagophthalmos 10.0 CRP IL6
31 multiple mitochondrial dysfunctions syndrome 10.0 CRP IL6
32 esotropia 10.0 CRP IL6
33 benign neonatal seizures 10.0 CRP IL6
34 premature menopause 10.0 CRP IL6
35 fallopian tube serous adenocarcinoma 10.0 CRP IL6
36 hyperlipoproteinemia type iv 10.0 CRP IL6
37 luxation of globe 10.0 CRP IL6
38 mixed mineral dust pneumoconiosis 10.0 CRP IL6
39 autoimmune disease of central nervous system 10.0 CRP IL6
40 plummer's disease 10.0 CRP IL6
41 allergic bronchopulmonary aspergillosis 10.0 CRP IL6
42 ischemic optic neuropathy 10.0 CRP IL6
43 focal dystonia 10.0 CRP IL6
44 pancreas lymphoma 10.0 CRP IL6
45 atrophy of prostate 10.0 CRP IL6
46 follicular adenoma 10.0 CRP IL6
47 carotenemia 10.0 CRP IL6
48 urinary bladder posterior wall cancer 10.0 CRP IL6
49 myiasis 10.0 CRP IL6
50 breast hemangiopericytoma 10.0 CRP IL6

Graphical network of the top 20 diseases related to Cold Agglutinin Disease:



Diseases related to Cold Agglutinin Disease

Symptoms & Phenotypes for Cold Agglutinin Disease

Human phenotypes related to Cold Agglutinin Disease:

56 32 (show all 14)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Very frequent (99-80%) HP:0002829
2 fatigue 56 32 Very frequent (99-80%) HP:0012378
3 headache 56 32 Occasional (29-5%) HP:0002315
4 back pain 56 32 Occasional (29-5%) HP:0003418
5 diarrhea 56 32 Occasional (29-5%) HP:0002014
6 nausea and vomiting 56 32 Occasional (29-5%) HP:0002017
7 muscle weakness 56 32 Very frequent (99-80%) HP:0001324
8 splenomegaly 56 32 Occasional (29-5%) HP:0001744
9 hepatomegaly 56 32 Occasional (29-5%) HP:0002240
10 hemolytic anemia 56 32 Very frequent (99-80%) HP:0001878
11 pallor 56 32 Very frequent (99-80%) HP:0000980
12 autoimmunity 56 32 Very frequent (99-80%) HP:0002960
13 lymphadenopathy 56 32 Occasional (29-5%) HP:0002716
14 abnormal urinary color 56 32 Occasional (29-5%) HP:0012086

Drugs & Therapeutics for Cold Agglutinin Disease

Drugs for Cold Agglutinin Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
2
rituximab Approved Phase 2 174722-31-7 10201696
3
Vidarabine Approved Phase 2 24356-66-9 32326 21704
4
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
5
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
6 Agglutinins Phase 2
7 Cold agglutinins Phase 2,Phase 1
8 Complement System Proteins Phase 2,Phase 1
9 Hemagglutinins Phase 2
10 Antibodies Phase 2,Phase 1
11 Antibodies, Monoclonal Phase 2,Phase 1
12 Anti-Infective Agents Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Antirheumatic Agents Phase 2
16 Antiviral Agents Phase 2
17 Immunoglobulins Phase 2,Phase 1
18 Immunosuppressive Agents Phase 2
19 Alkylating Agents Phase 2
20 Antineoplastic Agents, Alkylating Phase 2
21 Bendamustine Hydrochloride Phase 2
22 Anti-Inflammatory Agents Phase 2
23 Antineoplastic Agents, Hormonal Phase 2
24 glucocorticoids Phase 2
25 Hormone Antagonists Phase 2
26 Hormones Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
28 Acyclovir Phase 2
29 Pharmaceutical Solutions Phase 1
30
Copper Approved 15158-11-9, 7440-50-8 27099
31
Trastuzumab Approved, Investigational 180288-69-1 9903
32 Micronutrients
33 Trace Elements

Interventional clinical trials:


id Name Status NCT ID Phase
1 Therapy of Chronic Cold Agglutinin Disease With Eculizumab Completed NCT01303952 Phase 2
2 Therapy for Chronic Cold Agglutinin Disease Completed NCT00373594 Phase 2
3 Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Completed NCT02689986 Phase 2
4 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2
5 Short Course of Bortezomib in Anemic Patients With Refractory Cold Agglutinin Disease Active, not recruiting NCT01696474 Phase 2
6 Safety, Tolerability and Activity of TNT009 in Healthy Volunteers and Patients With Complement Mediated Disorders Recruiting NCT02502903 Phase 1
7 Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12 in Treating Patients With Advanced Leukemia Terminated NCT00618696 Phase 1
8 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713
9 Positron Emission Tomography in Women With Advanced HER2-Positive Breast Cancer Active, not recruiting NCT01093612

Search NIH Clinical Center for Cold Agglutinin Disease

Genetic Tests for Cold Agglutinin Disease

Anatomical Context for Cold Agglutinin Disease

MalaCards organs/tissues related to Cold Agglutinin Disease:

39
B Cells, Bone, Bone Marrow, T Cells, Neutrophil, Heart, Skin

Publications for Cold Agglutinin Disease

Articles related to Cold Agglutinin Disease:

(show top 50) (show all 154)
id Title Authors Year
1
Cold agglutinin disease complicated by acrocyanosis and necrosis. ( 28050677 )
2017
2
Cold agglutinin disease. ( 27913484 )
2016
3
Successful renal transplantation in a patient with cold agglutinin disease. ( 27011103 )
2016
4
Perioperative management of a patient with cold agglutinin disease undergoing segmental hepatectomy. ( 27827519 )
2016
5
Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity. ( 27198717 )
2016
6
Coomb's negative cold agglutinin disease secondary to mycoplasma pneumonia. ( 27728307 )
2016
7
Postoperative Recurrence of Invasive Thymoma with Cold Agglutinin Disease and Autoimmune Hemolytic Anemia. ( 27629968 )
2016
8
Two cases of primary cold agglutinin disease associated with megaloblastic anemia. ( 25918651 )
2015
9
Treatment solution by Miyahara et al.: Treatment of choice for aortic arch aneurysm in a patient with cold agglutinin disease. ( 26097925 )
2015
10
Cold agglutinin disease in sepsis: A rare entity. ( 26229347 )
2015
11
Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity. ( 26576277 )
2015
12
Alleviated anemia by bendamustine in cold agglutinin disease associated with small lymphocytic lymphoma. ( 25765801 )
2015
13
Aortic arch aneurysm in a patient with cold agglutinin disease. ( 25655279 )
2015
14
Cold Agglutinin Disease; A Laboratory Challenge. ( 26566452 )
2015
15
Glucocorticoid-Responsive Cold Agglutinin Disease in a Patient with Rheumatoid Arthritis. ( 26346552 )
2015
16
Cold agglutinin disease detected during open heart surgery. ( 24554828 )
2014
17
Cold agglutinin disease-associated digital gangrene treated with plasmapheresis. ( 25382532 )
2014
18
Primary bone marrow diffuse large B-cell lymphoma accompanying cold agglutinin disease: A case report with review of the literature. ( 24348825 )
2014
19
Long-term response of refractory primary cold agglutinin disease to eculizumab therapy. ( 23722501 )
2014
20
A man with "black fingers". Cold agglutinin disease (CAD). ( 24457440 )
2014
21
Cold agglutinin disease with erythrophagocytosis by neutrophils occurring during recovery phase of chickenpox. ( 24701117 )
2013
22
Cold agglutinin disease. ( 23757733 )
2013
23
Acute exacerbation of cold agglutinin disease during operation. ( 24478842 )
2013
24
Acronecrosis with cold agglutinin disease mimics diabetic gangrene. ( 23545690 )
2013
25
Blood clotting at room temperature in cold agglutinin disease. ( 23946942 )
2013
26
Therapy for chronic cold agglutinin disease: perspective for further improvements. ( 23399355 )
2013
27
Plasma exchange and rituximab treatment for lenalidomide-associated cold agglutinin disease. ( 22435421 )
2012
28
Successful treatment of IgM-monoclonal gammopathy of undetermined significance associated with cryoglobulinemia and cold agglutinin disease with immunochemotherapy with rituximab, fludarabine, and cyclophosphamide. ( 21901341 )
2012
29
Relapsed lymphoma preceded by cold agglutinin disease. ( 22611566 )
2012
30
Cold agglutinin disease with prolymphocytic leukemia. ( 22833870 )
2012
31
Primary cold agglutinin disease: a case report. ( 23738411 )
2012
32
Occurrence of lymphoplasmacytic lymphoma 6 years after amelioration of primary cold agglutinin disease by rituximab therapy. ( 22878940 )
2012
33
Normothermic total arch replacement without hypothermic circulatory arrest to treat aortic distal arch aneurysm in a patient with cold agglutinin disease. ( 21788303 )
2011
34
Cold agglutinin disease in fibrolamellar hepatocellular carcinoma: a rare association with a rare cancer variant. ( 21293066 )
2011
35
Primary gastrointestinal diffuse large B cell lymphoma presenting with cold agglutinin disease. ( 21887126 )
2011
36
Primary cold agglutinin disease. ( 22315851 )
2011
37
Erythrophagocytosis in cold agglutinin disease. ( 20502359 )
2011
38
Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. ( 23803987 )
2011
39
How I manage cold agglutinin disease. ( 21385173 )
2011
40
Type A aortic dissection with cold agglutinin disease. ( 21801929 )
2011
41
Improvement of the thermal amplitude after rituximab treatment for cold agglutinin disease with WaldenstrAPm's macroglobulinemia. ( 19513714 )
2010
42
Cold agglutinin disease. ( 19614954 )
2010
43
High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease. ( 20634373 )
2010
44
Transfusion medicine illustrated. Erythrophagocytosis in cold agglutinin disease. ( 21182630 )
2010
45
Case of erythrophagocytosis in a patient with mantle cell lymphoma and cold agglutinin disease. ( 20153050 )
2010
46
Transfusion medicine illustrated. The role of plasmapheresis in the multimodal treatment of anti-Pr cold agglutinin disease. ( 21064265 )
2010
47
Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease. ( 19372265 )
2009
48
Transient cold agglutinin disease with mycoplasma infection. ( 20214006 )
2009
49
A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica. ( 19340395 )
2009
50
Infectious mononucleosis with secondary cold agglutinin disease causing autoimmune haemolytic anaemia. ( 21894246 )
2009

Variations for Cold Agglutinin Disease

Expression for Cold Agglutinin Disease

Search GEO for disease gene expression data for Cold Agglutinin Disease.

Pathways for Cold Agglutinin Disease

GO Terms for Cold Agglutinin Disease

Cellular components related to Cold Agglutinin Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 CRP IGHM IL6 MS4A1
2 external side of plasma membrane GO:0009897 8.8 IGHM IL6 MS4A1

Biological processes related to Cold Agglutinin Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.37 CRP IL6
2 positive regulation of B cell activation GO:0050871 9.32 IGHM IL6
3 humoral immune response GO:0006959 9.26 IL6 MS4A1
4 defense response to Gram-negative bacterium GO:0050829 9.16 IGHM IL6
5 acute-phase response GO:0006953 8.96 CRP IL6
6 negative regulation of lipid storage GO:0010888 8.62 CRP IL6

Sources for Cold Agglutinin Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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