MCID: CLL015
MIFTS: 59

Collagen Disease malady

Summaries for Collagen Disease

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid... more...

MalaCards: Collagen Disease, also known as collagen diseases, is related to lupus erythematosus and skin disease. An important gene associated with Collagen Disease is SFTPD (surfactant protein D), and among its related pathways are Platelet Adhesion to exposed collagen and Protein digestion and absorption. The drugs prednisolone and prednisone and the compounds procollagen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and liver, and related mouse phenotypes are nervous system and skeleton.

Aliases & Classifications for Collagen Disease

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

collagen disease 8 10
collagen diseases 44 60
collagen disorder 8


External Ids:

Disease Ontology8 DOID:854
MeSH34 D003095
NCIt39 C27204

Related Diseases for Collagen Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.5THBD, APOH
2skin disease30.3IL2RA
3systemic lupus erythematosus30.3RPL7, LSM2, MBL2, APOH, CTLA4, FGA
4hypertension30.1NPPA
5vascular disease30.1APOH, FGF2, VWF, THBD, ELN
6hepatitis30.0CTLA4
7ischemia30.0FGF2, FGA
8connective tissue disease29.9COL2A1, COL1A1, SFTPD, APOH, CD36, RNPC3
9diabetes mellitus29.9NPPA, CTLA4, CD36, FGA, VWF, THBD
10osteogenesis imperfecta29.7COL2A1, COL1A1, CD36
11dermatomyositis29.7SFTPD
12glomerulonephritis29.7MBL2
13hypothyroidism29.7VWF, CTLA4
14pneumonia29.7SFTPD, MBL2, FGA
15eosinophilia29.7IL2RA, MBL2
16liver cirrhosis29.7NPPA, FGA
17disseminated intravascular coagulation29.7THBD, FGA
18mixed connective tissue disease29.7RNPC3, APOH, LSM2
19pulmonary fibrosis29.7ELN, CD36, SFTPD, COL1A1
20ehlers-danlos syndrome29.7COL2A1, COL1A1, CD36, ELN
21arthritis29.7IL18R1, FGF2, CTLA4, COL2A1
22uveitis29.7CTLA4, RNPC3, IL2RA, IL18R1
23primary biliary cirrhosis29.7MBL2, CTLA4, RNPC3, KRT19
24asthma29.7SFTPD, MBL2, CTLA4, IL2RA, IL18R1
25vasculitis29.7FGA, CTLA4, APOH, MBL2, VWF, THBD
26coronary artery disease29.7MBL2, HTR3A, NPPA, FGA, VWF, THBD
27leukemia29.7MBL2, HTR3A, FGA, FGF2, IL2RA, IL18R1
28rheumatoid arthritis29.7COL2A1, RPL7, SFTPD, MBL2, APOH, CTLA4
29atherosclerosis29.7MBL2, HTR3A, APOH, CD36, FGA, FGF2
30disseminated eosinophilic collagen disease10.3
31liver disease10.1
32alpha-2 deficient collagen disease10.1
33rheumatic fever10.1
34nasopharyngitis10.0
35agammaglobulinemia10.0
36nasopharyngeal disease10.0
37scleroderma10.0
38pulmonary disease, chronic obstructive10.0SFTPD
39peritonitis10.0IL18R1
40obesity10.0SFTPD
41blindness10.0COL2A1
42kawasaki disease10.0MBL2
43eclampsia10.0THBD
44cerebrovascular disease10.0APOH
45sarcoma10.0IL18R1
46retinal detachment10.0COL2A1
47aortic valve stenosis10.0ELN
48deficiency anemia10.0VWF
49diarrhea10.0HTR3A
50wilms tumor10.0IL18R1

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to collagen disease

Clinical Features for Collagen Disease

About this section

Drugs & Therapeutics for Collagen Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Collagen Disease

Drug clinical trials:

Search ClinicalTrials for Collagen Disease

Search NIH Clinical Center for Collagen Disease

Search CenterWatch for Collagen Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Collagen Disease

About this section

Anatomical Context for Collagen Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Collagen Disease:

32
Bone, Skin, Liver, Lung, Kidney, Heart, Endothelial, Smooth muscle, Colon, T cells, Testes, Eye, Skeletal muscle, Salivary gland, Pancreas, Brain, Nk cells, B cells, Bone marrow

Animal Models for Collagen Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Collagen Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.3KRT19, FGA, HTR3A, COL1A1, COL2A1
2MP:00053909.1COL2A1, CD36, FGA, FGF2, KRT19
3MP:00053708.9COL2A1, COL1A1, CTLA4, CD36, FGA, THBD
4MP:00053858.9COL2A1, COL1A1, NPPA, CTLA4, CD36, FGA
5MP:00053818.4COL2A1, COL1A1, CTLA4, CD36, FGA, IL2RA
6MP:00053878.2COL2A1, COL1A1, SFTPD, MBL2, HTR3A, CTLA4
7MP:00053978.1THBD, COL1A1, SFTPD, MBL2, HTR3A, NPPA
8MP:00053767.8APOH, HTR3A, MBL2, SFTPD, COL1A1, NPPA
9MP:00107687.6CTLA4, APOH, HTR3A, SFTPD, COL1A1, COL2A1

Publications for Collagen Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Collagen Disease:

(show top 50)    (show all 485)
idTitleAuthorsYear
1
Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease. (22963260)
2012
2
Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment. (21871007)
2011
3
A polygene network model for the complex pathological phenotypes of collagen disease. (22029672)
2011
4
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
5
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. (20307660)
2010
6
A recurrent mutation in type II collagen gene causes Legg-Calve- Perthes disease in a Japanese family. (17394019)
2007
7
Progression of collagenous colitis to Crohn's disease. (15827449)
2005
8
The significance of carboxy-terminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in assessment of bone disease in patients with multiple myeloma. (16263577)
2005
9
Autosomal recessive Alport's syndrome and benign familial hematuria are collagen type IV diseases. (14582039)
2003
10
Ullrich disease: collagen VI deficiency: EM suggests a new basis for muscular weakness. (12297580)
2002
11
Regulation of myocardial fibrillar collagen by angiotensin II. A role in hypertensive heart disease? (12505057)
2002
12
Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. (12373883)
2002
13
Quantitative analysis of glomerular type IV collagen alpha3-5 chain expression in children with thin basement membrane disease. (12218303)
2002
14
Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice. (11181084)
2001
15
Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome. (11175791)
2001
16
Thallium-201 myocardial SPET in patients with collagen disease. (11039455)
2000
17
Role of collagen hydrolysate in bone and joint disease. (11071580)
2000
18
Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (10772122)
2000
19
Urinary cross-linked N-telopeptides of type I collagen and bone metabolic diseases. (11593583)
1999
20
Expression of p53, p21 (Waf1/Cip1/Sdi1) and Fas antigen in collagen vascular and granulomatous lung diseases. (9817169)
1998
21
Linear IgA disease: a report of two dermal binding sera which recognize a pepsin-sensitive epitope (?NC-1 domain) of collagen type VII. (9390326)
1997
22
Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature. (8656563)
1996
23
Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone. (8831725)
1996
24
Endothelin and collagen vascular disease: a review with special reference to Raynaud's phenomenon and systemic sclerosis. (7827371)
1994
25
Anti-CD5 therapy decreases severity of established disease in collagen type II-induced arthritis in DBA/1 mice. (7527741)
1994
26
Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen. (7949092)
1994
27
Glycosaminoglycan-collagen interactions in vitro in the hydralazine-induced collagen disease-like syndrome. (8372554)
1993
28
Urinary collagen crosslink excretion: a better index of bone resorption than hydroxyproline in Paget's disease of bone? (8219934)
1993
29
Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases]. (8360993)
1993
30
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in collagen diseases associated with vasculitic syndrome in Japan. (1635282)
1992
31
Relationship between serum interleukin-4 or interferon-gamma level and B cell abnormality in patients with collagen vascular diseases]. (1767343)
1991
32
Studies on circulating immune complexes. I: Circulating immune complexes in various types of glomerulonephritis and collagen disease: a comparative study employing conglutinin solid phase radioimmunoassay and raji cell radioimmunoassay. (2739117)
1989
33
Effect of anti-inflammatory drugs on collagen-induced autoimmune inner ear disease. (3281543)
1988
34
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
35
Landmark perspective. Diffuse collagen disease. (6366271)
1984
36
Collagen and glycosaminoglycans in the human ovarian capsule with polycystic ovarian disease. (6526340)
1984
37
Animal models of collagen disease. (6750647)
1982
38
Increased solubility of collagen. A biochemical defect in the experimental hydralizine-induced collagen disease-like syndrome. (639926)
1978
39
Gel electrophoretic studies on proteoglycans and collagen of abnormal human growth cartilage: proteoglycan abnormalities in pseudoachondroplasia and in Kniest's disease. (127160)
1975
40
Collagen disease debuting as acute hepatitis. (4398837)
1971
41
Spontaneous disappearance of insulin-resistant diabetes mellitus in a patient with a collagen disease. A case report, with review of the literature for conditions associated with insulin resistance. (5416269)
1970
42
Collagen disease-like syndrome following administration of a benzodiazepine derivative. (6052929)
1967
43
Plant toxins and human disease. Collagen and lathyrism. (5331025)
1966
44
NUTRITION AND COLLAGEN DISEASE. (14140025)
1964
45
Phenylalanine and tyrosine in collagen diseases. Urinary excretion of general intermediary metabolites of tyrosine in patients with collagen disease and liver disease. (13729226)
1961
46
Collagen disease. (14400069)
1959
47
Clinical electrophoresis in collagen disease. (13339205)
1956
48
Collagen disease. (14819045)
1951
49
ACTH and cortisone in diffuse collagen disease and chronic dermatoses; differential therapeutic effects. (14803276)
1951
50
Pathogenesis of so-called diffuse vascular or collagen disease. (18112381)
1949

Genetic Variations for Collagen Disease

About this section

Expression for genes affiliated with Collagen Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for genes affiliated with Collagen Disease

About this section
Sources:
53Reactome, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 51QIAGEN
See all sources

Compounds for genes affiliated with Collagen Disease

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Collagen Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1procollagen4410.6COL2A1
2pge24410.5COL1A1
3estrogen4410.4MBL2, APOH, ELN
4phosphatidylserine44 28 1112.4APOH, CD36
5hydroxylysine4410.2ELN, SFTPD, COL1A1, COL2A1
611-dehydrothromboxane b24410.1THBD, VWF, FGA, APOH
7dermatan sulfate4410.0FGF2, VWF, THBD, ELN
8warfarin44 49 11 2412.9VWF, APOH, FGA, FGF2
9hydroxyproline44 11 2411.9COL1A1, ELN, COL2A1, CD36, SFTPD
106-ketoprostaglandin f1alpha449.9APOH, NPPA, FGA, VWF, THBD
11ivig449.8APOH, ELN, VWF, IL18R1, IL2RA
12thromboxane44 2410.8VWF, HTR3A, APOH, FGA, THBD
13agarose449.8APOH, THBD, SFTPD, MBL2, COL2A1, VWF
14infliximab44 49 1111.8IL18R1, APOH, CTLA4, IL2RA, FGF2
15aspartate449.7ELN, COL2A1, COL1A1, MBL2, KRT19
16dexamethasone44 49 28 1112.7SFTPD, FGF2, CTLA4, COL2A1, COL1A1, HTR3A
17txb2449.7VWF, APOH, FGA, THBD
18betacarotene449.7THBD, ELN, APOH, VWF, CD36, IL2RA
19heparin44 28 11 2412.7FGA, ELN, IL18R1, IL2RA, CD36, APOH
20pge1449.7VWF, APOH, NPPA, FGA, THBD
21losartan44 49 28 1112.7THBD, ELN, VWF, CD36, NPPA
22glycosaminoglycan449.6COL2A1, ELN, THBD, FGF2, CD36, COL1A1
23alginate449.6COL2A1, FGF2, CD36, ELN
24fitc449.6IL2RA, VWF, THBD, KRT19
25thalidomide44 49 59 1112.5IL2RA, CTLA4, THBD, CD36, FGF2, IL18R1
26phosphatidylcholine449.5ELN, THBD, IL2RA, FGF2, SFTPD, MBL2
27polysaccharide449.4THBD, IL18R1, IL2RA, FGF2, MBL2, SFTPD
28prostacyclin449.4THBD, VWF, FGF2, APOH, FGA, NPPA
29histamine44 28 2411.4VWF, THBD, IL2RA, FGA, HTR3A, SFTPD
30ascorbic acid44 2410.3FGF2, COL2A1, IL2RA, ELN, THBD, VWF
31prednisolone44 28 1111.3FGF2, APOH, IL18R1, VWF, MBL2, SFTPD
32carbohydrates449.3ELN, KRT19, THBD, MBL2, FGF2, VWF
33hyaluronic acid44 2410.3CD36, FGF2, VWF, THBD, KRT19, ELN
34fibrinogen449.3KRT19, ELN, THBD, VWF, FGA, APOH
35vitamin d449.3ELN, COL1A1, COL2A1, IL2RA, CD36, CTLA4
36lactate449.1ELN, VWF, THBD, SFTPD, APOH, KRT19
37creatinine449.1APOH, NPPA, CD36, FGA, THBD, KRT19
38paraffin449.0ELN, MBL2, CD36, FGF2, IL2RA, VWF
39steroid449.0CTLA4, IL2RA, IL18R1, SFTPD, KRT19, THBD
40cyclosporin a44 28 5911.0VWF, IL18R1, IL2RA, RNPC3, FGF2, NPPA
41thymidine44 2410.0CTLA4, SFTPD, COL1A1, FGF2, FGA, IL2RA
42nitric oxide44 11 2410.9NPPA, SFTPD, COL2A1, MBL2, VWF, THBD
43zinc44 249.8COL1A1, APOH, COL2A1, IL18R1, LSM2, MBL2
44cysteine448.7COL1A1, COL2A1, ELN, CTLA4, SFTPD, MBL2
45retinoic acid44 249.7COL2A1, COL1A1, CD36, FGF2, IL18R1, VWF
46serine448.7FGF2, IL18R1, CTLA4, FGA, LSM2, RNPC3
47alanine448.5CTLA4, THBD, IL18R1, FGF2, COL2A1, COL1A1
48arginine448.5ELN, THBD, VWF, IL18R1, IL2RA, RNPC3
49vegf448.2CD36, ELN, KRT19, APOH, IL18R1, IL2RA
50calcium44 49 11 2410.9NPPA, COL1A1, RNPC3, SFTPD, ELN, KRT19

GO Terms for genes affiliated with Collagen Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Collagen Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.0VWF, FGA
2external side of plasma membraneGO:0098979.3CTLA4, CD36, FGA, IL2RA, VWF
3cell surfaceGO:0099869.2MBL2, APOH, CD36, FGA, THBD
4extracellular spaceGO:0056158.9FGF2, COL2A1, COL1A1, SFTPD, MBL2, APOH
5extracellular regionGO:0055768.5COL2A1, COL1A1, SFTPD, MBL2, NPPA, FGA

Biological processes related to Collagen Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cartilage development involved in endochondral bone morphogenesisGO:06035110.2COL1A1, COL2A1
2negative regulation of fibrinolysisGO:05191810.2APOH, THBD
3negative regulation of blood coagulationGO:03019510.1THBD, APOH
4positive regulation of blood coagulationGO:03019410.0CD36, APOH
5platelet degranulationGO:0025769.8VWF, FGA, CD36
6platelet activationGO:0301689.8VWF, FGA, CD36, COL1A1
7blood coagulationGO:0075969.6COL1A1, CD36, FGA, VWF, THBD
8extracellular matrix organizationGO:0301989.3COL2A1, COL1A1, FGF2, ELN

Molecular functions related to Collagen Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.1COL1A1, COL2A1
2protein bindingGO:0055157.1ELN, COL1A1, RPL7, SFTPD, LSM2, MBL2

Products for genes affiliated with Collagen Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Collagen Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet