MCID: CLL015
MIFTS: 50

Collagen Disease malady

Categories: Genetic diseases

Aliases & Classifications for Collagen Disease

Aliases & Descriptions for Collagen Disease:

Name: Collagen Disease 12 14
Collagen Diseases 52 42 69
Collagen Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:854
MeSH 42 D003095
NCIt 47 C27204
UMLS 69 C0009326

Summaries for Collagen Disease

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to diffuse scleroderma and disseminated eosinophilic collagen disease. An important gene associated with Collagen Disease is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lung, and related phenotypes are mortality/aging and cardiovascular system

Wikipedia : 71 Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid... more...

Related Diseases for Collagen Disease

Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 diffuse scleroderma 28.7 CENPB CTGF EXOSC10 SNRNP70 TOP1 TSSK1B
2 disseminated eosinophilic collagen disease 12.0
3 alpha-2 deficient collagen disease 11.8
4 rheumatic disease 10.8
5 hypereosinophilic syndrome 10.8
6 meigel disease 10.8
7 ehlers-danlos syndrome 10.6
8 mixed connective tissue disease 10.6
9 lysyl hydroxylase 3 deficiency 10.6
10 urogenital adysplasia 10.4 THBD VWF
11 cngb3-related stargardt disease 1 10.3 COL1A1 COL1A2
12 isolated lissencephaly type 1 without known genetic defects 10.3 COL1A1 COL1A2
13 charcot-marie-tooth neuropathy type 2a 10.3 COL1A1 COL1A2
14 prph2-related retinitis pigmentosa 10.3 COL1A1 COL1A2
15 20p13 microdeletion syndrome 10.3 COL1A1 COL1A2
16 phyh-related refsum disease 10.3 COL1A1 COL1A2
17 myopathy-growth delay-intellectual disability-hypospadias syndrome 10.3 COL3A1 ELN
18 anal margin squamous cell carcinoma 10.3 ELN VWF
19 epileptic encephalopathy, early infantile, 36 10.3 COL1A1 COL1A2
20 czech dysplasia 10.3 APOH COL2A1 THBD
21 porphyria cutanea tarda 10.3 COL1A1 COL1A2
22 thyroid cancer, anaplastic 10.3 APOH THBD VWF
23 pregnancy loss, recurrent 1 10.3 APOH THBD VWF
24 immunodeficiency, common variable, 6 10.3 APOH THBD VWF
25 aggressive periodontitis 10.3 COL1A1 COL5A1 COL5A2
26 eng-related hereditary hemorrhagic telangiectasia 10.3 COL1A1 COL5A1 COL5A2
27 haemonchiasis 10.3 APOH THBD VWF
28 human herpesvirus 8 10.2 COL1A1 COL1A2
29 pilocytic astrocytoma of cerebellum 10.2 COL1A1 COL2A1
30 ehlers-danlos syndrome, classic type 10.2 COL3A1 COL5A1 ELN
31 bone structure disease 10.2 COL1A1 COL1A2 COL2A1
32 staphyloma posticum 10.2 COL3A1 COL5A1 COL5A2
33 bone development disease 10.2 APOH THBD VWF
34 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.2 ELN NPPA VWF
35 osteogenesis imperfecta, type iii 10.2 COL1A1 COL1A2
36 cholesteatoma of attic 10.2 COL1A2 COL3A1 ELN
37 giant papillary conjunctivitis 10.2 APOH THBD VWF
38 sclerocornea 10.2 COL1A1 COL1A2 COL2A1
39 neuropathy, distal hereditary motor, type iia 10.2 COL1A1 COL1A2 COL2A1 COL3A1
40 respiratory system disease 10.2 APOH CENPB LSM2
41 factor xiiia deficiency 10.2 COL1A1 COL1A2 COL3A1 COL5A2
42 sialadenitis 10.2 APOH CENPB THBD VWF
43 cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2 10.1 COL1A1 COL1A2
44 pericarditis 10.1 APOH ELN THBD VWF
45 eating disorder 10.1 APOH THBD VWF
46 facial nerve neoplasm 10.1 EXOSC10 SNRNP70
47 muscle hypertrophy 10.1 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2
48 tinea manuum 10.1 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2
49 acute proliferative glomerulonephritis 10.0 APOH THBD VWF
50 agraphia 10.0 CENPB COL1A1 COL1A2 CTGF TOP1

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease

Symptoms & Phenotypes for Collagen Disease

MGI Mouse Phenotypes related to Collagen Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.97 APOH CENPB COL1A1 COL1A2 COL2A1 COL3A1
2 cardiovascular system MP:0005385 9.96 COL2A1 COL3A1 COL5A1 COL5A2 CTGF NPPA
3 normal MP:0002873 9.61 CENPB COL1A1 COL1A2 COL2A1 COL5A1 COL5A2
4 respiratory system MP:0005388 9.17 COL1A1 COL2A1 COL3A1 COL5A2 CTGF SFTPD

Drugs & Therapeutics for Collagen Disease

Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 834)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2 64-17-5 702
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
6
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
7
Tacrolimus Approved, Investigational Phase 4,Phase 3,Early Phase 1 104987-11-3 445643 439492
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
9
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
10
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
11
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 15307-86-5 3033
12
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
13
Cimetidine Approved Phase 4,Phase 3,Phase 2 51481-61-9 2756
14
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
15
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
16
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
17
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5353980 5359476
18
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
19
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
20
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
21
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
22
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
23
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
24
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
25
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
26
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
27
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
28
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
29
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22204-53-1 1302 156391
30
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
31
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
32
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1 50-48-6 2160
33
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
34
Tranylcypromine Approved Phase 4 155-09-9 441233
35
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 5281106 54677470
36
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
37
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
38
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 1197-18-8 5526
39
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
40
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 202409-33-4 123619
41
Nabumetone Approved Phase 4 42924-53-8 4409
42
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
43
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
44
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
45
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1 161796-78-7, 119141-88-7 4594 9579578
46
Milnacipran Approved Phase 4,Phase 2,Phase 3,Phase 1 92623-85-3 65833
47
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1 58-39-9 4748
48
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 27203-92-5 33741
49
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 76-42-6 5284603
50
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8

Interventional clinical trials:

(show top 50) (show all 5000)
id Name Status NCT ID Phase
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
3 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4
4 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
5 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4
6 A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Unknown status NCT00208442 Phase 4
7 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
8 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4
9 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4
10 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
11 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4
12 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4
13 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
14 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4
15 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4
16 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4
17 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4
18 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
19 To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee Unknown status NCT02049606 Phase 4
20 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4
21 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
22 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4
23 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
24 Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women Unknown status NCT01926158 Phase 4
25 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
26 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4
27 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
28 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
29 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4
30 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4
31 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4
32 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
33 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
34 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
35 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
36 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4
37 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4
38 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4
39 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
40 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4
41 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4
42 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
43 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
44 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4
45 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4
46 Bipolar Sealer Aquamantys Use in Total Knee Replacement Unknown status NCT01736644 Phase 4
47 Comparison Between Anterior and Direct Lateral Approach in Total Hip Arthroplasty Unknown status NCT01578746 Phase 4
48 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4
49 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4
50 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: collagen diseases

Genetic Tests for Collagen Disease

Anatomical Context for Collagen Disease

MalaCards organs/tissues related to Collagen Disease:

39
Skin, Liver, Lung, Endothelial, Testes, Neutrophil, Skeletal Muscle

Publications for Collagen Disease

Articles related to Collagen Disease:

(show top 50) (show all 195)
id Title Authors Year
1
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. ( 26327779 )
2015
2
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. ( 23405989 )
2013
3
Serum levels of tenascin-C in collagen diseases. ( 23834524 )
2013
4
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. ( 22944580 )
2012
5
A polygene network model for the complex pathological phenotypes of collagen disease. ( 22029672 )
2011
6
Left ventricular myocardial ischemia in collagen disease associated with pulmonary hypertension: an evaluation by rest-stress gated SPECT and coronary angiography. ( 21597395 )
2011
7
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei in collagen disease patient. ( 21083708 )
2010
8
Haemorrhoids - a collagen disease? ( 19614671 )
2010
9
Polygene network in collagen disease. ( 20453438 )
2010
10
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. ( 20307660 )
2010
11
[Genetics of autoimmune and collagen diseases]. ( 19507500 )
2009
12
Myopia: a collagen disease? ( 19616386 )
2009
13
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer. ( 18461292 )
2008
14
Cytokines in collagen disease-related atherogenesis. ( 17143992 )
2006
15
Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease. ( 16320409 )
2005
16
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. ( 14621587 )
2003
17
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. ( 12373883 )
2002
18
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]. ( 12373879 )
2002
19
Tc-99m DTPA renography in patients with collagen disease. ( 11245107 )
2001
20
Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models. ( 11016428 )
2000
21
Clinical significance of ventilation/perfusion scans in collagen disease patients. ( 11210092 )
2000
22
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. ( 11092254 )
2000
23
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations ( 10980338 )
2000
24
Thallium-201 myocardial SPET in patients with collagen disease. ( 11039455 )
2000
25
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. ( 10980337 )
2000
26
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension. ( 10513835 )
1999
27
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. ( 10594844 )
1999
28
[Clinical evaluation of serum cytokine from patients with collagen diseases]. ( 10340006 )
1999
29
Collagen disease: the enemy within. ( 9863615 )
1998
30
Serum concentrations of vascular endothelial growth factor in collagen diseases. ( 9990370 )
1998
31
Leishmaniasis mimicking collagen disease. ( 9251665 )
1997
32
Alport syndrome: clinical and genetic correlation in a type-IV collagen disease. ( 9399052 )
1997
33
Unusual systemic lupus erythematosus-like reaction to minocycline in a patient with acne and antecedent collagen disease. ( 19078088 )
1996
34
[Studies of serum markers in patients with interstitial pneumonia/pulmonary fibrosis complicated with collagen diseases: clinical evaluation of CYFRA21-1]. ( 9122823 )
1996
35
Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature. ( 8656563 )
1996
36
Severe reaction after chemoradiotherapy of nasopharyngeal carcinoma with collagen disease. ( 7591915 )
1995
37
Study of interleukin-2 receptor in schistosomiasis mansoni and its analogous changes in collagen diseases and schistosomal arthropathy. ( 7665927 )
1995
38
[Detection of anti small nuclear ribonucleoprotein antibody in patients with collagen disease--a comparison of sensitivities of four methods]. ( 7570209 )
1995
39
[Ribosomal protein L7 as an autoantigen in patients with systemic lupus erythematosus, mixed collagen disease and rheumatoid arthritis]. ( 7856252 )
1994
40
Immunological changes in hydroxyurea-induced collagen disease. ( 7947215 )
1994
41
[Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases]. ( 8360993 )
1993
42
Glycosaminoglycan-collagen interactions in vitro in the hydralazine-induced collagen disease-like syndrome. ( 8372554 )
1993
43
Addition of serum from patients with collagen diseases increases to cultured human endothelial cells production and release of von Willebrand factor. ( 8438904 )
1993
44
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in collagen diseases associated with vasculitic syndrome in Japan. ( 1635282 )
1992
45
Appearance of beta-human atrial natriuretic peptide in collagen disease. ( 1831836 )
1991
46
Plasma coagulation and fibrinolysis parameters in patients with collagen diseases, and analysis of the multimeric structure of von Willebrand factor (vWF). ( 1756253 )
1991
47
Protein losing enteropathy associated with collagen diseases. ( 2015012 )
1991
48
The clearance of colloidal particles by Kupffer cells in collagen disease. ( 2094346 )
1990
49
[Clinical usefulness of determining the antibodies to soluble nuclear antigens in various collagen diseases]. ( 2125351 )
1990
50
Studies on circulating immune complexes. I: Circulating immune complexes in various types of glomerulonephritis and collagen disease: a comparative study employing conglutinin solid phase radioimmunoassay and raji cell radioimmunoassay. ( 2739117 )
1989

Variations for Collagen Disease

Expression for Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for Collagen Disease

Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2
Show member pathways
12.81 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
3
Show member pathways
12.72 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4
Show member pathways
12.35 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
5
Show member pathways
11.97 COL1A1 COL1A2 COL2A1 VWF
6
Show member pathways
11.95 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
7 11.87 COL1A1 COL1A2 COL3A1 VWF
8 11.73 COL1A1 COL1A2 COL3A1 THBD
9
Show member pathways
11.72 COL1A1 COL1A2 COL3A1
10 11.67 COL1A1 COL1A2 COL3A1
11 11.45 COL1A1 COL1A2 COL2A1 COL3A1
12 11.27 COL1A1 COL1A2 COL3A1 VWF
13 11.15 COL1A1 COL1A2 COL3A1
14 10.89 COL1A2 COL3A1 COL5A1 COL5A2

GO Terms for Collagen Disease

Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.85 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2 extracellular matrix GO:0031012 9.76 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
3 collagen trimer GO:0005581 9.5 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4 collagen type V trimer GO:0005588 9.43 COL5A1 COL5A2
5 collagen type I trimer GO:0005584 9.4 COL1A1 COL1A2
6 proteinaceous extracellular matrix GO:0005578 9.32 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
7 extracellular region GO:0005576 10.1 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
8 extracellular space GO:0005615 10 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.85 COL1A1 COL1A2 THBD VWF
2 regulation of immune response GO:0050776 9.83 COL1A1 COL1A2 COL2A1 COL3A1 SFTPD
3 platelet activation GO:0030168 9.8 COL1A1 COL1A2 COL3A1 VWF
4 skeletal system development GO:0001501 9.8 COL1A1 COL1A2 COL2A1 COL3A1 COL5A2
5 ossification GO:0001503 9.76 COL1A1 COL2A1 COL5A2 CTGF
6 cellular response to amino acid stimulus GO:0071230 9.67 COL1A1 COL1A2 COL3A1 COL5A2
7 collagen catabolic process GO:0030574 9.63 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
8 blood vessel development GO:0001568 9.62 COL1A1 COL1A2 COL3A1 COL5A1
9 tissue homeostasis GO:0001894 9.61 COL2A1 CTGF
10 blood coagulation, intrinsic pathway GO:0007597 9.61 APOH VWF
11 negative regulation of blood coagulation GO:0030195 9.6 APOH THBD
12 supramolecular fiber organization GO:0097435 9.59 COL3A1 COL5A1
13 protein heterotrimerization GO:0070208 9.58 COL1A1 COL1A2
14 negative regulation of fibrinolysis GO:0051918 9.58 APOH THBD
15 skin morphogenesis GO:0043589 9.57 COL1A1 COL1A2
16 positive regulation of cardiac muscle contraction GO:0060452 9.56 CTGF NPPA
17 skin development GO:0043588 9.56 COL1A1 COL3A1 COL5A1 COL5A2
18 extracellular matrix organization GO:0030198 9.56 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
19 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.54 COL1A1 COL2A1
20 collagen biosynthetic process GO:0032964 9.52 COL1A1 COL5A1
21 eye morphogenesis GO:0048592 9.51 COL5A1 COL5A2
22 negative regulation of endodermal cell differentiation GO:1903225 9.48 COL5A1 COL5A2
23 collagen fibril organization GO:0030199 9.1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.56 COL3A1 COL5A1 CTGF VWF
2 SMAD binding GO:0046332 9.5 COL1A2 COL3A1 COL5A2
3 protease binding GO:0002020 9.46 COL1A1 COL1A2 COL3A1 VWF
4 platelet-derived growth factor binding GO:0048407 9.35 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
5 extracellular matrix structural constituent GO:0005201 9.17 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

Sources for Collagen Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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