MCID: CLL015
MIFTS: 52

Collagen Disease malady

Summaries for Collagen Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid... more...

MalaCards: Collagen Disease, also known as collagen diseases, is related to systemic lupus erythematosus and vascular disease. An important gene associated with Collagen Disease is SFTPD (surfactant protein D), and among its related pathways are Platelet Adhesion to exposed collagen and Protein digestion and absorption. The drugs prednisolone and prednisone and the compounds procollagen and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and skeleton.

Aliases & Classifications for Collagen Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

collagen disease 8 10
collagen diseases 45 61
collagen disorder 8


External Ids:

Disease Ontology8 DOID:854
MeSH35 D003095
NCIt40 C27204

Related Diseases for Collagen Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Collagen Disease family:

collagen type vi-related disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.3APOH, MBL2, LSM2, RPL7, VWF, IL2RA
2vascular disease30.1VWF, ELN, APOH, THBD, FGF2
3rheumatic disease30.1CTLA4, IL2RA, APOH, COL2A1, RNPC3, LSM2
4hepatitis c30.0RNPC3
5osteogenesis imperfecta type i29.8COL1A1, CD36
6osteogenesis imperfecta29.8COL2A1, COL1A1, CD36
7nephritis29.8RNPC3, APOH
8insulin resistance29.8IL18R1, VWF
9polymyositis29.8SFTPD, RNPC3, CTLA4
10mixed connective tissue disease29.8RNPC3, APOH, LSM2
11hepatitis b29.8CTLA4, IL2RA, MBL2
12arthritis29.8IL18R1, COL2A1, CTLA4, FGF2
13uveitis29.8CTLA4, RNPC3, IL2RA, IL18R1
14primary biliary cirrhosis29.8CTLA4, RNPC3, MBL2, KRT19
15asthma29.8SFTPD, MBL2, IL18R1, IL2RA, CTLA4
16vasculitis29.8MBL2, THBD, VWF, FGA, CTLA4, APOH
17atherosclerosis29.8FGA, MBL2, FGF2, ELN, THBD, VWF
18disseminated eosinophilic collagen disease10.3
19alpha-2 deficient collagen disease10.2
20ehlers–danlos syndrome10.1
21rheumatic fever10.1
22hepatitis d10.0
23n syndrome10.0
24hepatitis a10.0
25agammaglobulinemia10.0
26periarteritis nodosa10.0
27nutrition disease10.0
28lip disease10.0
29pulmonary disease, chronic obstructive10.0SFTPD
30peritonitis10.0IL18R1
31dermatomyositis10.0SFTPD
32obesity10.0SFTPD
33blindness10.0COL2A1
34kawasaki disease10.0MBL2
35glomerulonephritis10.0MBL2
36eclampsia10.0THBD
37cerebrovascular disease10.0APOH
38sarcoma10.0IL18R1
39retinal detachment10.0COL2A1
40aortic valve stenosis10.0ELN
41deficiency anemia10.0VWF
42diarrhea10.0HTR3A
43wilms tumor10.0IL18R1
44achondroplasia10.0COL2A1
45meningitis10.0MBL2
46dementia10.0HTR3A
47hyperglycemia10.0FGA
48hepatitis10.0CTLA4
49rabies10.0RNPC3
50measles10.0RNPC3

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to collagen disease

Clinical Features for Collagen Disease

Drugs & Therapeutics for Collagen Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Collagen Disease

Drug clinical trials:

Search ClinicalTrials for Collagen Disease

Search NIH Clinical Center for Collagen Disease

Search CenterWatch for Collagen Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Collagen Disease

Anatomical Context for Collagen Disease

Animal Models for Collagen Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Collagen Disease

Sources:
51PubMed
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Articles related to Collagen Disease:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
Integrins I+4 and I+M, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. (23344661)
2013
2
Are collagenous and lymphocytic colitis different aspects of the same disease? (23016916)
2012
3
Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment. (21871007)
2011
4
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study. (21557718)
2011
5
The relationship between androgens, regulators of collagen metabolism, and Peyronie's disease: a case control study. (20584122)
2010
6
Blocking of CD27-CD70 pathway by anti-CD70 antibody ameliorates joint disease in murine collagen-induced arthritis. (19710474)
2009
7
Effect of statins on collagen type I degradation in patients with coronary artery disease and atrial fibrillation. (18178406)
2008
8
Organ-specific collagen expression: implications for renal disease. (16286786)
2006
9
Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features. (17042681)
2006
10
Caffey disease: an unlikely collagenopathy. (15864344)
2005
11
Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. (15618538)
2005
12
Insulin-like growth factor I gene microsatellite repeat, collagen type Ialpha1 gene Sp1 polymorphism, and bone disease in primary biliary cirrhosis. (15256976)
2004
13
Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. (14621587)
2003
14
Tyrosinemia I, a model for human diseases mediated by 2-oxoacid-utilizing dioxygenases: hepatotoxin suppression by NTBC does not normalize hepatic collagen metabolism. (12142814)
2002
15
Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease. (12149201)
2002
16
Von Willebrand factor collagen binding activity in the diagnosis of von Willebrand disease: an alternative to ristocetin co-factor activity? (11260057)
2001
17
Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice. (11181084)
2001
18
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. (11735694)
2001
19
Serum collagen type VI and XIV and hyaluronic acid as early indicators for altered connective tissue turnover in alcoholic liver disease. (11575459)
2001
20
The bisphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone. (11344044)
2001
21
Increased gelsolin expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine. (10623895)
2000
22
Mutations in fibrillar collagens (types I, II, III, and XI), fibril- associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. (9101290)
1997
23
Plasma collagen-binding vitronectin activated by heparin and dextran sulfate in chronic liver disease. (9387191)
1997
24
Collagen-binding activity of plasma vitronectin in chronic liver disease. (8814365)
1996
25
A comparative clinical study: the use of human type I collagen with and without the addition of metronidazole in the GTR method of treatment of periodontal disease. (7560238)
1995
26
Study of interleukin-2 receptor in schistosomiasis mansoni and its analogous changes in collagen diseases and schistosomal arthropathy. (7665927)
1995
27
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
28
Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression. (8132760)
1994
29
Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen. (7949092)
1994
30
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article. (8433257)
1993
31
Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. (8442431)
1993
32
Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. (8253711)
1993
33
Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. (8518539)
1993
34
Activity of type IV collagenases in benign and malignant breast disease. (8494711)
1993
35
Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases. (1425210)
1992
36
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
37
Cancer in collagen disease. A statistical analysis by reviewing the Annual of Pathological Autopsy Cases (Nippon Boken Shuho) in Japan. (6148140)
1984
38
Collagen and glycosaminoglycans in the human ovarian capsule with polycystic ovarian disease. (6526340)
1984
39
Animal models of collagen disease. (6750647)
1982
40
A study of essential fatty acid metabolism as a precursor of prostaglandin in collagen disease. (7344138)
1981
41
Letter: Relief of intractable pain associated with collagen disease. (4408280)
1974
42
Peripheral ischemia and collagen disease: clinical manifestations, diagnosis, and treatment. (4402964)
1972
43
Medical testimony in a case of systemic lupus erythematosus (SLE)--a collagen disease--showing the direct and cross-examination of the plaintiff's internist. Part I. (5550300)
1971
44
Cutaneous amyloidosis. Classification, pathogenesis and relation to "collagen disease". (5472644)
1970
45
Linear scleroderma with hemiatrophy: report of three cases associated with collagen-vascular disease. (5907143)
1966
46
NEUROLOGIC MANIFESTATIONS OF COLLAGEN DISEASE: A REPORT OF FOUR CASES. (14224299)
1964
47
Collagen disease and the chronic biological false positive phenomenon. (13691640)
1961
48
Some of the Clinical Aspects of Collagen Disease Including Treatment with and without Steroids. (19312627)
1956
49
Fibrogenesis imperfecta ossium; a generalised disease of bone characterised by defective formation of the collagen fibres of the bone matrix. (13295341)
1956
50
Collagen disease: pathology and clinical course. (14862556)
1951

Genetic Variations for Collagen Disease

Expression for genes affiliated with Collagen Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for genes affiliated with Collagen Disease

Sources:
54Reactome, 30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 52QIAGEN
See all sources

Compounds for genes affiliated with Collagen Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Collagen Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1procollagen4510.6COL2A1
2pge24510.5COL1A1
3estrogen4510.4MBL2, APOH, ELN
4phosphatidylserine45 29 1112.4APOH, CD36
5hydroxylysine4510.2ELN, SFTPD, COL1A1, COL2A1
611-dehydrothromboxane b24510.1THBD, VWF, FGA, APOH
7dermatan sulfate4510.0FGF2, VWF, THBD, ELN
8warfarin45 50 11 2412.9VWF, APOH, FGA, FGF2
9hydroxyproline45 11 2411.9COL1A1, ELN, COL2A1, CD36, SFTPD
106-ketoprostaglandin f1alpha459.9APOH, NPPA, FGA, VWF, THBD
11ivig459.8APOH, ELN, VWF, IL18R1, IL2RA
12thromboxane45 2410.8VWF, HTR3A, APOH, FGA, THBD
13agarose459.8APOH, THBD, SFTPD, MBL2, COL2A1, VWF
14infliximab45 50 1111.8IL18R1, APOH, CTLA4, IL2RA, FGF2
15aspartate459.7ELN, COL2A1, COL1A1, MBL2, KRT19
16dexamethasone45 50 29 1112.7SFTPD, FGF2, CTLA4, COL2A1, COL1A1, HTR3A
17txb2459.7VWF, APOH, FGA, THBD
18betacarotene459.7THBD, ELN, APOH, VWF, CD36, IL2RA
19heparin45 29 11 2412.7FGA, ELN, IL18R1, IL2RA, CD36, APOH
20pge1459.7VWF, APOH, NPPA, FGA, THBD
21losartan45 50 29 1112.7THBD, ELN, VWF, CD36, NPPA
22glycosaminoglycan459.6COL2A1, ELN, THBD, FGF2, CD36, COL1A1
23alginate459.6COL2A1, FGF2, CD36, ELN
24fitc459.6IL2RA, VWF, THBD, KRT19
25thalidomide45 50 60 1112.5IL2RA, CTLA4, THBD, CD36, FGF2, IL18R1
26phosphatidylcholine459.5ELN, THBD, IL2RA, FGF2, SFTPD, MBL2
27polysaccharide459.4THBD, IL18R1, IL2RA, FGF2, MBL2, SFTPD
28prostacyclin459.4THBD, VWF, FGF2, APOH, FGA, NPPA
29histamine45 29 2411.4VWF, THBD, IL2RA, FGA, HTR3A, SFTPD
30ascorbic acid45 2410.3FGF2, COL2A1, IL2RA, ELN, THBD, VWF
31prednisolone45 29 1111.3FGF2, APOH, IL18R1, VWF, MBL2, SFTPD
32carbohydrates459.3ELN, KRT19, THBD, MBL2, FGF2, VWF
33hyaluronic acid45 2410.3CD36, FGF2, VWF, THBD, KRT19, ELN
34fibrinogen459.3KRT19, ELN, THBD, VWF, FGA, APOH
35vitamin d459.3ELN, COL1A1, COL2A1, IL2RA, CD36, CTLA4
36lactate459.1ELN, VWF, THBD, SFTPD, APOH, KRT19
37creatinine459.1APOH, NPPA, CD36, FGA, THBD, KRT19
38paraffin459.0ELN, MBL2, CD36, FGF2, IL2RA, VWF
39steroid459.0CTLA4, IL2RA, IL18R1, SFTPD, KRT19, THBD
40cyclosporin a45 29 6011.0VWF, IL18R1, IL2RA, RNPC3, FGF2, NPPA
41thymidine45 2410.0CTLA4, SFTPD, COL1A1, FGF2, FGA, IL2RA
42nitric oxide45 11 2410.9NPPA, SFTPD, COL2A1, MBL2, VWF, THBD
43zinc45 249.8COL1A1, APOH, COL2A1, IL18R1, LSM2, MBL2
44cysteine458.7COL1A1, COL2A1, ELN, CTLA4, SFTPD, MBL2
45retinoic acid45 249.7COL2A1, COL1A1, CD36, FGF2, IL18R1, VWF
46serine458.7FGF2, IL18R1, CTLA4, FGA, LSM2, RNPC3
47alanine458.5CTLA4, THBD, IL18R1, FGF2, COL2A1, COL1A1
48arginine458.5ELN, THBD, VWF, IL18R1, IL2RA, RNPC3
49vegf458.2CD36, ELN, KRT19, APOH, IL18R1, IL2RA
50calcium45 50 11 2410.9NPPA, COL1A1, RNPC3, SFTPD, ELN, KRT19

GO Terms for genes affiliated with Collagen Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Collagen Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.0VWF, FGA
2external side of plasma membraneGO:0098979.3CTLA4, CD36, FGA, IL2RA, VWF
3cell surfaceGO:0099869.2MBL2, APOH, CD36, FGA, THBD
4extracellular spaceGO:0056158.9FGF2, COL2A1, COL1A1, SFTPD, MBL2, APOH
5extracellular regionGO:0055768.5COL2A1, COL1A1, SFTPD, MBL2, NPPA, FGA

Biological processes related to Collagen Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cartilage development involved in endochondral bone morphogenesisGO:06035110.2COL1A1, COL2A1
2negative regulation of fibrinolysisGO:05191810.2APOH, THBD
3negative regulation of blood coagulationGO:03019510.1THBD, APOH
4positive regulation of blood coagulationGO:03019410.0CD36, APOH
5platelet degranulationGO:0025769.8VWF, FGA, CD36
6platelet activationGO:0301689.8VWF, FGA, CD36, COL1A1
7blood coagulationGO:0075969.6COL1A1, CD36, FGA, VWF, THBD
8extracellular matrix organizationGO:0301989.3COL2A1, COL1A1, FGF2, ELN

Molecular functions related to Collagen Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.1COL1A1, COL2A1
2protein bindingGO:0055157.1ELN, COL1A1, RPL7, SFTPD, LSM2, MBL2

Products for genes affiliated with Collagen Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Collagen Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet