Aliases & Classifications for Collagen Disease

MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 14
Collagen Diseases 51 41 69
Collagen Disorder 12 72

External Ids:

Disease Ontology 12 DOID:854
MeSH 41 D003095
NCIt 46 C27204
UMLS 69 C0009326

Summaries for Collagen Disease

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to rheumatic disease and ehlers-danlos syndrome. An important gene associated with Collagen Disease is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 72 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

Related Diseases for Collagen Disease

Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 31.7 APOH CENPB TOP1
2 ehlers-danlos syndrome 31.1 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2
3 purpura 30.0 APOH THBD VWF
4 thrombosis 29.7 APOH THBD VWF
5 vasculitis 29.7 APOH THBD VWF
6 systemic lupus erythematosus 29.5 APOH RPL7 SNRNP70 THBD TLR9 VWF
7 vascular disease 29.5 APOH ELN THBD VWF
8 scleroderma, familial progressive 29.4 COL1A1 COL1A2 CTGF TOP1
9 connective tissue disease 27.6 APOH CENPB COL1A1 COL1A2 COL3A1 COL5A1
10 disseminated eosinophilic collagen disease 12.1
11 alpha-2-deficient collagen disease 12.0
12 hypereosinophilic syndrome 10.9
13 mixed connective tissue disease 10.7
14 bone fragility with contractures, arterial rupture, and deafness 10.7
15 unilateral absence of a pulmonary artery 10.6 THBD VWF
16 ehlers-danlos/osteogenesis imperfecta syndrome 10.6 COL1A1 COL1A2
17 familial abdominal aortic aneurysm 10.6 COL3A1 ELN
18 ehlers-danlos syndrome, arthrochalasia type, 1 10.5 COL1A1 COL1A2
19 plica syndrome 10.5 ELN VWF
20 high bone mass osteogenesis imperfecta 10.5 COL1A1 COL1A2
21 thrombophilia due to activated protein c resistance 10.5 APOH THBD VWF
22 thrombotic thrombocytopenic purpura 10.5 APOH THBD VWF
23 pilomyxoid astrocytoma 10.5 COL1A1 COL2A1
24 thrombophilia due to thrombin defect 10.5 APOH THBD VWF
25 osteogenesis imperfecta, type viii 10.5 COL1A1 COL1A2
26 pelvic organ prolapse 10.5 COL1A1 COL3A1 ELN
27 osteogenesis imperfecta, type vii 10.4 COL1A1 COL1A2
28 type i ehlers-danlos syndrome 10.4 COL1A1 COL5A1 COL5A2
29 ehlers-danlos syndrome type 2 10.4 COL1A1 COL5A1 COL5A2
30 ehlers-danlos syndrome, vascular type 10.4 COL3A1 COL5A1 ELN
31 bone development disease 10.4 COL1A1 COL1A2 COL2A1
32 hellp syndrome 10.4 APOH THBD VWF
33 varicose veins 10.4 COL3A1 ELN VWF
34 hypermobility syndrome 10.4 COL3A1 COL5A1 COL5A2
35 pfeiffer syndrome 10.4 COL1A1 COL3A1 TLR9
36 lipoblastoma 10.3 COL1A2 COL3A1
37 intracranial aneurysm 10.3 COL1A2 COL3A1 ELN
38 idiopathic interstitial pneumonia 10.3 CTGF SFTPD TLR9
39 crest syndrome 10.3 CENPB TOP1
40 spondyloepiphyseal dysplasia congenita 10.3 COL1A1 COL1A2 COL2A1 COL3A1
41 brittle bone disorder 10.3 COL1A1 COL1A2 COL2A1 COL3A1
42 larsen-like syndrome 10.2 COL1A1 COL1A2 COL3A1 COL5A2
43 arterial tortuosity syndrome 10.2 COL5A2 ELN
44 raynaud disease 10.2 APOH CENPB THBD VWF
45 stiff skin syndrome 10.2 COL1A2 CTGF
46 facial hemiatrophy 10.2 EXOSC10 SNRNP70
47 immune system disease 10.2 APOH SCHIP1 TLR9 VWF
48 scoliosis 10.2 COL1A1 COL1A2 COL2A1
49 osteogenesis imperfecta, type vi 10.2 COL1A1 COL1A2
50 hypersensitivity reaction disease 10.1 APOH SCHIP1 SNRNP70 TLR9

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease

Symptoms & Phenotypes for Collagen Disease

MGI Mouse Phenotypes related to Collagen Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 COL2A1 COL3A1 COL5A1 COL5A2 CTGF SCHIP1
2 mortality/aging MP:0010768 10.03 COL5A1 COL5A2 CTGF SCHIP1 SFTPD THBD
3 growth/size/body region MP:0005378 10 CENPB COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
4 digestive/alimentary MP:0005381 9.92 COL1A1 COL2A1 COL3A1 CTGF SCHIP1 THBD
5 normal MP:0002873 9.61 CENPB COL1A1 COL1A2 COL2A1 COL5A1 COL5A2
6 respiratory system MP:0005388 9.17 COL1A1 COL2A1 COL3A1 COL5A2 CTGF SFTPD

Drugs & Therapeutics for Collagen Disease

Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 921)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
2
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 46507594 772
3
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
6
Tacrolimus Approved, Investigational Phase 4,Phase 3,Early Phase 1 104987-11-3 445643 439492
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
9
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
10
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
11
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
12
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 15307-86-5 3033
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
14
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2 51481-61-9 2756
15
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
16
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
17
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
18
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5359476 5353980
19
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 9004-61-9 53477741 24759
20
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
21
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
22
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6, 75614-87-8 774
23
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
24
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
25
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
26
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
27
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
28
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
30
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
31
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
32
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22204-53-1 156391 1302
33
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
34
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2 471-34-1
35
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
36
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1 50-48-6 2160
37
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 38396-39-3, 2180-92-9 2474
38
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
39
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 54677470 5281106
40
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
41
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
42
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
43
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
44
Chromium Approved Phase 4,Phase 3,Phase 2 7440-47-3 27668
45
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 202409-33-4 123619
46
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
47
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
48
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
49
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1 161796-78-7, 119141-88-7 9579578 4594
50
Milnacipran Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 92623-85-3 65833

Interventional clinical trials:

(show top 50) (show all 5993)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
3 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
4 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
5 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
6 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
7 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
8 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
9 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
10 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
11 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
12 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
13 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
14 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
15 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
16 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
17 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
18 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
19 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
20 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
21 Comparing Conservative Therapies for the Alleviation of Knee Pain in Knee Osteoarthritis Unknown status NCT02320500 Phase 4
22 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
23 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
24 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
25 Daily Activity and Gait Analysis After Viscosupplement Injection Among Hip Osteoarthritis Patients Unknown status NCT02086474 Phase 4 Hyaluronan;Bupivacaine
26 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
27 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
28 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
29 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
30 Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women Unknown status NCT01926158 Phase 4 Denosumb;Placebo (for denosumab)
31 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
32 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
33 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
34 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
35 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
36 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
37 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
38 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
39 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
40 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
41 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
42 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
43 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
44 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
45 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
46 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
47 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
48 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
49 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
50 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: collagen diseases

Genetic Tests for Collagen Disease

Anatomical Context for Collagen Disease

MalaCards organs/tissues related to Collagen Disease:

38
Bone, Eye, Testes, Bone Marrow, Heart, Skin, Brain

Publications for Collagen Disease

Articles related to Collagen Disease:

(show top 50) (show all 197)
# Title Authors Year
1
Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. ( 28895531 )
2017
2
A scabies outbreak in a diabetic and collagen disease ward: Management and prevention. ( 28105102 )
2016
3
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. ( 26327779 )
2015
4
Serum levels of tenascin-C in collagen diseases. ( 23834524 )
2013
5
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. ( 23405989 )
2013
6
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. ( 22944580 )
2012
7
Left ventricular myocardial ischemia in collagen disease associated with pulmonary hypertension: an evaluation by rest-stress gated SPECT and coronary angiography. ( 21597395 )
2011
8
A polygene network model for the complex pathological phenotypes of collagen disease. ( 22029672 )
2011
9
Polygene network in collagen disease. ( 20453438 )
2010
10
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei in collagen disease patient. ( 21083708 )
2010
11
Haemorrhoids - a collagen disease? ( 19614671 )
2010
12
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. ( 20307660 )
2010
13
[Genetics of autoimmune and collagen diseases]. ( 19507500 )
2009
14
Myopia: a collagen disease? ( 19616386 )
2009
15
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer. ( 18461292 )
2008
16
Cytokines in collagen disease-related atherogenesis. ( 17143992 )
2006
17
Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease. ( 16320409 )
2005
18
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. ( 14621587 )
2003
19
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. ( 12373883 )
2002
20
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]. ( 12373879 )
2002
21
Tc-99m DTPA renography in patients with collagen disease. ( 11245107 )
2001
22
Thallium-201 myocardial SPET in patients with collagen disease. ( 11039455 )
2000
23
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. ( 11092254 )
2000
24
Clinical significance of ventilation/perfusion scans in collagen disease patients. ( 11210092 )
2000
25
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. ( 10980337 )
2000
26
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations ( 10980338 )
2000
27
Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models. ( 11016428 )
2000
28
[Clinical evaluation of serum cytokine from patients with collagen diseases]. ( 10340006 )
1999
29
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension. ( 10513835 )
1999
30
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. ( 10594844 )
1999
31
Collagen disease: the enemy within. ( 9863615 )
1998
32
Serum concentrations of vascular endothelial growth factor in collagen diseases. ( 9990370 )
1998
33
Leishmaniasis mimicking collagen disease. ( 9251665 )
1997
34
Alport syndrome: clinical and genetic correlation in a type-IV collagen disease. ( 9399052 )
1997
35
Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature. ( 8656563 )
1996
36
Unusual systemic lupus erythematosus-like reaction to minocycline in a patient with acne and antecedent collagen disease. ( 19078088 )
1996
37
[Studies of serum markers in patients with interstitial pneumonia/pulmonary fibrosis complicated with collagen diseases: clinical evaluation of CYFRA21-1]. ( 9122823 )
1996
38
[Detection of anti small nuclear ribonucleoprotein antibody in patients with collagen disease--a comparison of sensitivities of four methods]. ( 7570209 )
1995
39
Severe reaction after chemoradiotherapy of nasopharyngeal carcinoma with collagen disease. ( 7591915 )
1995
40
Study of interleukin-2 receptor in schistosomiasis mansoni and its analogous changes in collagen diseases and schistosomal arthropathy. ( 7665927 )
1995
41
[Ribosomal protein L7 as an autoantigen in patients with systemic lupus erythematosus, mixed collagen disease and rheumatoid arthritis]. ( 7856252 )
1994
42
Immunological changes in hydroxyurea-induced collagen disease. ( 7947215 )
1994
43
Addition of serum from patients with collagen diseases increases to cultured human endothelial cells production and release of von Willebrand factor. ( 8438904 )
1993
44
[Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases]. ( 8360993 )
1993
45
Glycosaminoglycan-collagen interactions in vitro in the hydralazine-induced collagen disease-like syndrome. ( 8372554 )
1993
46
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in collagen diseases associated with vasculitic syndrome in Japan. ( 1635282 )
1992
47
Protein losing enteropathy associated with collagen diseases. ( 2015012 )
1991
48
Plasma coagulation and fibrinolysis parameters in patients with collagen diseases, and analysis of the multimeric structure of von Willebrand factor (vWF). ( 1756253 )
1991
49
Appearance of beta-human atrial natriuretic peptide in collagen disease. ( 1831836 )
1991
50
[Clinical usefulness of determining the antibodies to soluble nuclear antigens in various collagen diseases]. ( 2125351 )
1990

Variations for Collagen Disease

Expression for Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for Collagen Disease

Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2
Show member pathways
12.9 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
3
Show member pathways
12.77 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4
Show member pathways
12.46 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
5
Show member pathways
12 COL1A1 COL1A2 COL2A1 VWF
6
Show member pathways
11.97 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
7
Show member pathways
11.95 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
8 11.9 COL1A1 COL1A2 COL3A1 VWF
9 11.77 COL1A1 COL1A2 COL3A1 THBD
10
Show member pathways
11.75 COL1A1 COL1A2 COL3A1
11 11.71 COL1A1 COL1A2 COL3A1
12 11.52 COL1A1 COL1A2 COL2A1 COL3A1
13 11.38 COL1A1 COL1A2 COL3A1 VWF
14 11.19 COL1A1 COL1A2 COL3A1
15 11.09 COL1A2 COL3A1 COL5A1 COL5A2
16 10.46 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

GO Terms for Collagen Disease

Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.85 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2 extracellular matrix GO:0031012 9.81 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
3 collagen trimer GO:0005581 9.5 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4 collagen type V trimer GO:0005588 9.43 COL5A1 COL5A2
5 collagen type I trimer GO:0005584 9.4 COL1A1 COL1A2
6 proteinaceous extracellular matrix GO:0005578 9.36 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
7 extracellular region GO:0005576 10.1 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
8 extracellular space GO:0005615 10 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.84 COL1A1 COL1A2 THBD VWF
2 regulation of immune response GO:0050776 9.83 COL1A1 COL1A2 COL2A1 COL3A1 SFTPD
3 platelet activation GO:0030168 9.8 COL1A1 COL1A2 COL3A1 VWF
4 skeletal system development GO:0001501 9.8 COL1A1 COL1A2 COL2A1 COL3A1 COL5A2
5 ossification GO:0001503 9.76 COL1A1 COL2A1 COL5A2 CTGF
6 cellular response to amino acid stimulus GO:0071230 9.67 COL1A1 COL1A2 COL3A1 COL5A2
7 collagen catabolic process GO:0030574 9.63 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
8 blood vessel development GO:0001568 9.62 COL1A1 COL1A2 COL3A1 COL5A1
9 cartilage condensation GO:0001502 9.61 COL2A1 CTGF
10 tissue homeostasis GO:0001894 9.61 COL2A1 CTGF
11 blood coagulation, intrinsic pathway GO:0007597 9.6 APOH VWF
12 negative regulation of blood coagulation GO:0030195 9.59 APOH THBD
13 supramolecular fiber organization GO:0097435 9.58 COL3A1 COL5A1
14 protein heterotrimerization GO:0070208 9.58 COL1A1 COL1A2
15 negative regulation of fibrinolysis GO:0051918 9.57 APOH THBD
16 skin morphogenesis GO:0043589 9.56 COL1A1 COL1A2
17 skin development GO:0043588 9.56 COL1A1 COL3A1 COL5A1 COL5A2
18 extracellular matrix organization GO:0030198 9.56 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
19 collagen biosynthetic process GO:0032964 9.55 COL1A1 COL5A1
20 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.52 COL1A1 COL2A1
21 eye morphogenesis GO:0048592 9.51 COL5A1 COL5A2
22 negative regulation of endodermal cell differentiation GO:1903225 9.48 COL5A1 COL5A2
23 collagen fibril organization GO:0030199 9.1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.56 COL3A1 COL5A1 CTGF VWF
2 SMAD binding GO:0046332 9.5 COL1A2 COL3A1 COL5A2
3 protease binding GO:0002020 9.46 COL1A1 COL1A2 COL3A1 VWF
4 platelet-derived growth factor binding GO:0048407 9.35 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
5 extracellular matrix structural constituent GO:0005201 9.17 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

Sources for Collagen Disease

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