MCID: CLL015
MIFTS: 50

Collagen Disease

Categories: Genetic diseases

Aliases & Classifications for Collagen Disease

MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 14
Collagen Diseases 52 42 69
Collagen Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:854
MeSH 42 D003095
NCIt 47 C27204
UMLS 69 C0009326

Summaries for Collagen Disease

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to diffuse scleroderma and disseminated eosinophilic collagen disease. An important gene associated with Collagen Disease is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Methotrexate and Leflunomide have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and heart, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid... more...

Related Diseases for Collagen Disease

Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 diffuse scleroderma 27.6 CENPB CTGF EXOSC10 SNRNP70 TOP1 TSSK1B
2 disseminated eosinophilic collagen disease 11.9
3 alpha-2 deficient collagen disease 11.8
4 unna-thost palmoplantar keratoderma 10.9 THBD VWF
5 congenital erosive and vesicular dermatosis 10.8 COL1A1 COL1A2
6 cln12 disease 10.8 COL1A1 COL1A2
7 carbonic anhydrase va deficiency 10.8 COL1A1 COL1A2
8 familial or sporadic hemiplegic migraine 10.8 COL3A1 ELN
9 prpf3-related retinitis pigmentosa 10.8 COL1A1 COL1A2
10 anal margin squamous cell carcinoma 10.8 ELN VWF
11 pens syndrome 10.8 COL1A1 COL1A2
12 cerebellar astrocytoma 10.8 COL1A1 COL2A1
13 pfn1-related amyotrophic lateral sclerosis 10.8 COL1A1 COL1A2
14 epilepsy with neurodevelopmental defects 10.8 COL1A1 COL1A2
15 stickler sydrome, type i, nonsyndromic ocular 10.7 APOH COL2A1 THBD
16 osteogenesis imperfecta, type viii 10.7 COL1A1 COL1A2
17 thumb stiff brachydactyly mental retardation 10.7 APOH THBD VWF
18 osteogenesis imperfecta, type iv 10.7 COL1A1 COL1A2
19 thrombophilia due to activated protein c resistance 10.7 APOH THBD VWF
20 pregnancy loss, recurrent 2 10.7 APOH THBD VWF
21 ehlers-danlos syndrome, type vi 10.7 COL1A1 PLOD1
22 actinic prurigo 10.7 COL3A1 PLOD1
23 human herpesvirus 8 10.7 COL1A1 COL1A2
24 partial sensory epilepsy 10.6 APOH THBD VWF
25 bone remodeling disease 10.6 APOH THBD VWF
26 aggressive periodontitis 10.6 COL1A1 COL5A1 COL5A2
27 eif2b4-related childhood ataxia with central nervous system hypomyelination/vanishing white matter 10.6 COL1A1 COL5A1 COL5A2
28 acute proliferative glomerulonephritis 10.6 APOH THBD VWF
29 ischemic bone disease 10.6 COL1A1 COL1A2 COL2A1
30 ehlers-danlos syndrome, classic type 10.6 COL3A1 COL5A1 ELN
31 ehlers-danlos syndrome 10.6
32 mixed connective tissue disease 10.6
33 giant papillary conjunctivitis 10.6 APOH THBD VWF
34 staphyloma posticum 10.6 COL3A1 COL5A1 COL5A2
35 lysyl hydroxylase 3 deficiency 10.6
36 cholangiocarcinoma, susceptibility to 10.5 COL5A1 PLOD1
37 gonococcal keratitis 10.5 COL5A2 PLOD1
38 chickenpox 10.5 APOH THBD VWF
39 strongyloidiasis 10.5 COL1A2 COL3A1 ELN
40 lipoic acid biosynthesis defects 10.5 COL1A2 COL3A1
41 carnitine palmitoyltransferase ii deficiency 10.5 COL1A1 COL1A2 PLOD1
42 lacrimal system cancer 10.5 APOH SCHIP1 VWF
43 thrombocytopenia with or without dyserythropoietic anemia 10.4 COL3A1 PLOD1
44 pericarditis 10.4 APOH ELN THBD VWF
45 sulfite oxidase deficiency 10.4 COL1A1 COL1A2 COL2A1 COL3A1
46 parotid disease 10.4 CENPB TOP1 VWF
47 periodic limb movement disorder 10.4 CENPB TOP1
48 graves disease 2 10.4 COL5A2 ELN
49 deafness, autosomal recessive 91 10.4 COL1A1 COL1A2 COL3A1 COL5A2
50 respiratory system disease 10.4 APOH CENPB TOP1

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease

Symptoms & Phenotypes for Collagen Disease

MGI Mouse Phenotypes related to Collagen Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.14 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2 growth/size/body region MP:0005378 10.06 COL2A1 COL3A1 COL5A1 COL5A2 CTGF SCHIP1
3 mortality/aging MP:0010768 10.03 COL2A1 COL3A1 COL5A1 COL5A2 CTGF PLOD1
4 digestive/alimentary MP:0005381 9.91 COL1A1 COL2A1 COL3A1 CTGF SCHIP1 THBD
5 integument MP:0010771 9.86 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2 CTGF
6 normal MP:0002873 9.61 CTGF EXOSC10 THBD CENPB COL1A1 COL1A2
7 respiratory system MP:0005388 9.17 COL1A1 COL2A1 COL3A1 COL5A2 CTGF SFTPD

Drugs & Therapeutics for Collagen Disease

Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 923)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
2
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
3
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
4
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
5
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
7
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
9
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5353980 5359476
10
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2216-51-5 16666
11
Fluorouracil Approved Phase 4 51-21-8 3385
12
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
13
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
14
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
15
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 1197-18-8 5526
16
Tranylcypromine Approved Phase 4 155-09-9 441233
17
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
18
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1 161796-78-7, 119141-88-7 4594 9579578
19
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22204-53-1 1302 156391
20
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
21
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
22
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
23
Ropivacaine Approved Phase 4,Phase 2,Phase 3 84057-95-4 71273 175805
24
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
25
Cimetidine Approved Phase 4,Phase 3,Phase 2 51481-61-9 2756
26
Hyoscyamine Approved Phase 4 101-31-5 64692
27
Milnacipran Approved Phase 4,Phase 2,Phase 3,Phase 1 92623-85-3 65833
28
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
29
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
30
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 202409-33-4 123619
31
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
32
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 15307-86-5 3033
33
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
34
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
35
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1 50-48-6 2160
36
Cyclobenzaprine Approved Phase 4,Phase 3,Phase 2 303-53-7 2895
37
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
38
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
39
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
40
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
41 Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1
42
Calcium Carbonate Approved Phase 4,Phase 3,Phase 2 471-34-1
43
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
44
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
45
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
46
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
47
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
48
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
49
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
50
Linezolid Approved, Investigational Phase 4 165800-03-3 441401

Interventional clinical trials:

(show top 50) (show all 5781)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
3 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
4 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
5 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
6 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
7 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
8 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
9 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
10 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
11 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
12 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
13 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
14 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
15 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
16 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
17 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
18 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
19 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
20 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
21 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
22 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
23 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
24 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
25 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
26 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
27 Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women Unknown status NCT01926158 Phase 4 Denosumb;Placebo (for denosumab)
28 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
29 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
30 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
31 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
32 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
33 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
34 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
35 Roentgen Stereophotogrammetric Analysis (RSA) Trial Comparing Trabecular Metal Monoblock and Modular Tibial Components Unknown status NCT01180595 Phase 4
36 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
37 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
38 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
39 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
40 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
41 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
42 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
43 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
44 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
45 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
46 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
47 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
48 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran
49 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4 etoricoxib
50 Bipolar Sealer Aquamantys Use in Total Knee Replacement Unknown status NCT01736644 Phase 4

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: collagen diseases

Genetic Tests for Collagen Disease

Anatomical Context for Collagen Disease

MalaCards organs/tissues related to Collagen Disease:

39
Bone, Eye, Heart, Bone Marrow, Testes, Skin, Brain

Publications for Collagen Disease

Articles related to Collagen Disease:

(show top 50) (show all 197)
id Title Authors Year
1
Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. ( 28895531 )
2017
2
A scabies outbreak in a diabetic and collagen disease ward: Management and prevention. ( 28105102 )
2016
3
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. ( 26327779 )
2015
4
Serum levels of tenascin-C in collagen diseases. ( 23834524 )
2013
5
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. ( 23405989 )
2013
6
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. ( 22944580 )
2012
7
A polygene network model for the complex pathological phenotypes of collagen disease. ( 22029672 )
2011
8
Left ventricular myocardial ischemia in collagen disease associated with pulmonary hypertension: an evaluation by rest-stress gated SPECT and coronary angiography. ( 21597395 )
2011
9
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei in collagen disease patient. ( 21083708 )
2010
10
Haemorrhoids - a collagen disease? ( 19614671 )
2010
11
Polygene network in collagen disease. ( 20453438 )
2010
12
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. ( 20307660 )
2010
13
Myopia: a collagen disease? ( 19616386 )
2009
14
[Genetics of autoimmune and collagen diseases]. ( 19507500 )
2009
15
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer. ( 18461292 )
2008
16
Cytokines in collagen disease-related atherogenesis. ( 17143992 )
2006
17
Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease. ( 16320409 )
2005
18
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. ( 14621587 )
2003
19
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]. ( 12373879 )
2002
20
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. ( 12373883 )
2002
21
Tc-99m DTPA renography in patients with collagen disease. ( 11245107 )
2001
22
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations ( 10980338 )
2000
23
Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models. ( 11016428 )
2000
24
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. ( 11092254 )
2000
25
Thallium-201 myocardial SPET in patients with collagen disease. ( 11039455 )
2000
26
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. ( 10980337 )
2000
27
Clinical significance of ventilation/perfusion scans in collagen disease patients. ( 11210092 )
2000
28
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension. ( 10513835 )
1999
29
[Clinical evaluation of serum cytokine from patients with collagen diseases]. ( 10340006 )
1999
30
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. ( 10594844 )
1999
31
Collagen disease: the enemy within. ( 9863615 )
1998
32
Serum concentrations of vascular endothelial growth factor in collagen diseases. ( 9990370 )
1998
33
Alport syndrome: clinical and genetic correlation in a type-IV collagen disease. ( 9399052 )
1997
34
Leishmaniasis mimicking collagen disease. ( 9251665 )
1997
35
[Studies of serum markers in patients with interstitial pneumonia/pulmonary fibrosis complicated with collagen diseases: clinical evaluation of CYFRA21-1]. ( 9122823 )
1996
36
Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature. ( 8656563 )
1996
37
Unusual systemic lupus erythematosus-like reaction to minocycline in a patient with acne and antecedent collagen disease. ( 19078088 )
1996
38
Study of interleukin-2 receptor in schistosomiasis mansoni and its analogous changes in collagen diseases and schistosomal arthropathy. ( 7665927 )
1995
39
[Detection of anti small nuclear ribonucleoprotein antibody in patients with collagen disease--a comparison of sensitivities of four methods]. ( 7570209 )
1995
40
Severe reaction after chemoradiotherapy of nasopharyngeal carcinoma with collagen disease. ( 7591915 )
1995
41
Immunological changes in hydroxyurea-induced collagen disease. ( 7947215 )
1994
42
[Ribosomal protein L7 as an autoantigen in patients with systemic lupus erythematosus, mixed collagen disease and rheumatoid arthritis]. ( 7856252 )
1994
43
[Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases]. ( 8360993 )
1993
44
Glycosaminoglycan-collagen interactions in vitro in the hydralazine-induced collagen disease-like syndrome. ( 8372554 )
1993
45
Addition of serum from patients with collagen diseases increases to cultured human endothelial cells production and release of von Willebrand factor. ( 8438904 )
1993
46
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in collagen diseases associated with vasculitic syndrome in Japan. ( 1635282 )
1992
47
Plasma coagulation and fibrinolysis parameters in patients with collagen diseases, and analysis of the multimeric structure of von Willebrand factor (vWF). ( 1756253 )
1991
48
Appearance of beta-human atrial natriuretic peptide in collagen disease. ( 1831836 )
1991
49
Protein losing enteropathy associated with collagen diseases. ( 2015012 )
1991
50
[Clinical usefulness of determining the antibodies to soluble nuclear antigens in various collagen diseases]. ( 2125351 )
1990

Variations for Collagen Disease

Expression for Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for Collagen Disease

Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2
Show member pathways
12.81 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
3
Show member pathways
12.72 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4
Show member pathways
12.21 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
5
Show member pathways
12 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
6
Show member pathways
11.97 COL1A1 COL1A2 COL2A1 VWF
7 11.87 COL1A1 COL1A2 COL3A1 VWF
8 11.73 COL1A1 COL1A2 COL3A1 THBD
9
Show member pathways
11.72 COL1A1 COL1A2 COL3A1
10 11.67 COL1A1 COL1A2 COL3A1
11 11.45 COL1A1 COL1A2 COL2A1 COL3A1
12 11.27 COL1A1 COL1A2 COL3A1 VWF
13 11.15 COL1A1 COL1A2 COL3A1
14 11.09 COL1A2 COL3A1 COL5A1 COL5A2

GO Terms for Collagen Disease

Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.76 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
2 endoplasmic reticulum lumen GO:0005788 9.73 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
3 collagen trimer GO:0005581 9.5 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4 collagen type V trimer GO:0005588 9.43 COL5A1 COL5A2
5 collagen type I trimer GO:0005584 9.4 COL1A1 COL1A2
6 proteinaceous extracellular matrix GO:0005578 9.32 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
7 extracellular region GO:0005576 10.11 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
8 extracellular space GO:0005615 10.02 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.84 COL1A1 COL1A2 THBD VWF
2 regulation of immune response GO:0050776 9.83 COL1A1 COL1A2 COL2A1 COL3A1 SFTPD
3 platelet activation GO:0030168 9.8 COL1A1 COL1A2 COL3A1 VWF
4 skeletal system development GO:0001501 9.8 COL1A1 COL1A2 COL2A1 COL3A1 COL5A2
5 ossification GO:0001503 9.76 COL1A1 COL2A1 COL5A2 CTGF
6 blood vessel development GO:0001568 9.67 COL1A1 COL1A2 COL3A1 COL5A1
7 collagen catabolic process GO:0030574 9.63 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
8 cellular response to amino acid stimulus GO:0071230 9.62 COL1A1 COL1A2 COL3A1 COL5A2
9 cartilage condensation GO:0001502 9.61 COL2A1 CTGF
10 tissue homeostasis GO:0001894 9.61 COL2A1 CTGF
11 blood coagulation, intrinsic pathway GO:0007597 9.6 APOH VWF
12 supramolecular fiber organization GO:0097435 9.59 COL3A1 COL5A1
13 negative regulation of blood coagulation GO:0030195 9.58 APOH THBD
14 protein heterotrimerization GO:0070208 9.58 COL1A1 COL1A2
15 negative regulation of fibrinolysis GO:0051918 9.57 APOH THBD
16 skin morphogenesis GO:0043589 9.56 COL1A1 COL1A2
17 skin development GO:0043588 9.56 COL1A1 COL3A1 COL5A1 COL5A2
18 extracellular matrix organization GO:0030198 9.56 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
19 collagen biosynthetic process GO:0032964 9.55 COL1A1 COL5A1
20 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.52 COL1A1 COL2A1
21 eye morphogenesis GO:0048592 9.51 COL5A1 COL5A2
22 negative regulation of endodermal cell differentiation GO:1903225 9.48 COL5A1 COL5A2
23 collagen fibril organization GO:0030199 9.1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 APOH COL1A1 COL1A2 COL2A1 SCHIP1 VWF
2 integrin binding GO:0005178 9.56 COL3A1 COL5A1 CTGF VWF
3 SMAD binding GO:0046332 9.5 COL1A2 COL3A1 COL5A2
4 protease binding GO:0002020 9.46 COL1A1 COL1A2 COL3A1 VWF
5 platelet-derived growth factor binding GO:0048407 9.35 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
6 extracellular matrix structural constituent GO:0005201 9.17 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2

Sources for Collagen Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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