MCID: CLL021
MIFTS: 39

Collagenous Colitis malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

Aliases & Descriptions for Collagenous Colitis:

Name: Collagenous Colitis 12 50 52 14
Colitis, Collagenous 42 69
Microscopic Colitis, Collagenous Type 50

Classifications:



External Ids:

Disease Ontology 12 DOID:0060183
ICD10 33 K52.89
MeSH 42 D046729
NCIt 47 C27021
SNOMED-CT 64 19311003
UMLS 69 C0238067

Summaries for Collagenous Colitis

NIH Rare Diseases : 50 collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to peritonitis and diversion colitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3). The drugs Budesonide and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related phenotype is Increased shRNA abundance (Z-score > 2).

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 71 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 peritonitis 29.8 EPX MPO
2 diversion colitis 29.3 CD79A CHGA
3 lymphocytic colitis 11.3
4 microscopic colitis 11.2
5 collagenous gastritis 11.2
6 colitis 10.8
7 mucositis 10.2
8 amelogenesis imperfecta 1j 10.2 EPX RNASE3
9 spastic paraplegia 3a, autosomal dominant 10.2 EPX RNASE3
10 epidermoid brain tumor 10.2 EPX MPO
11 necrotizing gastritis 10.2 EPX RNASE3
12 appendix carcinoid tumor 10.2 EPX RNASE3
13 acute gonococcal prostatitis 10.2 EPX RNASE3
14 astrocytoma 10.2 MPO RNASE3
15 sm-ahnmd 10.2 CHGA SCG2
16 cartilage cancer 10.1 CHGA EPX
17 bare lymphocyte syndrome, type i 10.1 MPO NOS2 RNASE3
18 ethmoid sinusitis 10.1 EPX RNASE3
19 gmppa-cdg 10.1 CHGA CHGB
20 inflamed seborrheic keratosis 10.1 EPX RNASE3
21 ulcerative colitis 10.1
22 heart septal defect 10.1 CD79A RNASE3
23 mitochondrial complex ii deficiency 10.1 CHGA CHGB
24 penis basaloid carcinoma 10.1 CD79A RNASE3
25 arthritis 10.1
26 brown shrimp allergy 10.1 CD79A RNASE3
27 scalp dermatosis 10.1 EPX MPO RNASE3
28 pediatric meningioma 10.1 CD79A MPO
29 glucocorticoid resistance 10.1 EPX MPO RNASE3
30 apricot allergy 10.1 CD79A RNASE3
31 colonic benign neoplasm 10.1 CD79A MPO
32 eosinophilic fasciitis 10.0 CD79A MPO
33 diarrhea 10.0
34 subacute glomerulonephritis 10.0 CD79A MPO
35 dysentery 10.0 CD79A MPO
36 uveitis 10.0 CD79A MPO
37 intravascular angioleiomyoma 10.0 CD79A RNASE3
38 cyclotropia 10.0 CD79A MPO
39 dermatomycosis 10.0 CD79A MPO
40 orbit alveolar rhabdomyosarcoma 10.0 CD79A RNASE3
41 omsk hemorrhagic fever 10.0 CD79A MPO
42 retinal telangiectasia 10.0 CHGA CHGB
43 postinflammatory pulmonary fibrosis 10.0 CD79A MPO
44 pancreatic serous cystadenoma 10.0 CD79A MPO
45 rosacea conjunctivitis 10.0 CD79A MPO
46 immune-complex glomerulonephritis 10.0 CD79A MPO
47 eyelid neoplasm 10.0 CD79A RNASE3
48 lymphangiectasia, intestinal 10.0 CD79A RNASE3
49 vulvar disease 9.9 CD79A MPO RNASE3
50 dislocation of ear ossicle 9.9 CD79A MPO RNASE3

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis

Symptoms & Phenotypes for Collagenous Colitis

GenomeRNAi Phenotypes related to Collagenous Colitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.64 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 CHGA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.64 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.64 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.64 CHGA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.64 CHGA MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CD79A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.64 CHGA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.64 CHGA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.64 MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.64 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.64 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 CD79A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.64 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 CD79A CHGA MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.64 CD79A

Drugs & Therapeutics for Collagenous Colitis

Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3 51333-22-3 63006 5281004
2 Anti-Asthmatic Agents Phase 3
3 Anti-Inflammatory Agents Phase 3
4 Autonomic Agents Phase 3
5 Bronchodilator Agents Phase 3
6 glucocorticoids Phase 3
7 Hormone Antagonists Phase 3
8 Hormones Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Respiratory System Agents Phase 3
12 Analgesics Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Antirheumatic Agents Phase 3
16 Mesalamine Phase 3 89-57-6
17 Pharmaceutical Solutions
18 Antacids
19 Anti-Ulcer Agents
20
Bismuth 7440-69-9 16682734 105143
21 Gastrointestinal Agents
22 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3
2 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3
3 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3
4 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3
5 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
6 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Recruiting NCT01504048
7 Treatment of Microscopic Colitis Terminated NCT00184171

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

Anatomical Context for Collagenous Colitis

MalaCards organs/tissues related to Collagenous Colitis:

39
Colon, Small Intestine, T Cells, Endothelial, Heart, Liver, Kidney

Publications for Collagenous Colitis

Articles related to Collagenous Colitis:

(show top 50) (show all 436)
id Title Authors Year
1
Smoking Status Influences Clinical Outcome in Collagenous Colitis. ( 26721941 )
2016
2
Letter: oral low-dose methotrexate for collagenous colitis - authors' reply. ( 27250589 )
2016
3
Immunological Differences between Lymphocytic and Collagenous Colitis. ( 26928959 )
2016
4
Optimal management of collagenous colitis: a review. ( 26929656 )
2016
5
Collagenous colitis presenting as spontaneous perforation in an 80A year old woman: Report of a Case. ( 27716080 )
2016
6
Spontaneous colonic perforation: a rare complication of collagenous colitis. ( 27178398 )
2016
7
Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis. ( 27725290 )
2016
8
Letter: oral low-dose methotrexate for collagenous colitis. ( 27250588 )
2016
9
Comparison of Clinical Features, Treatment and Outcomes of Collagenous Sprue, Celiac Disease and Collagenous Colitis. ( 27620860 )
2016
10
Anti-PD1-induced collagenous colitis in a melanoma patient. ( 26990271 )
2016
11
Automated image analysis in the study of collagenous colitis. ( 27114713 )
2016
12
Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea. ( 26854205 )
2016
13
Tofacitinib Response in Juvenile Idiopathic Arthritis (JIA) and Collagenous Colitis. ( 27870773 )
2016
14
Collagenous colitis and Crohn's disease: Guilty or innocent bystander? ( 27474197 )
2016
15
Collagenous Colitis Refractory to Budesonide: is the Upper Gastrointestinal Tract Involved? ( 27557639 )
2016
16
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
17
Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. ( 26450480 )
2015
18
P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis. ( 25717636 )
2015
19
Collagenous colitis with mucosal ulcerations in a patient without nonsteroidal anti-inflammatory drug or lansoprazole use. ( 26130218 )
2015
20
Collagenous Colitis Associated with Protein-losing Enteropathy. ( 26568022 )
2015
21
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. ( 26019474 )
2015
22
DOP082. Genome-wide association identifies multiple collagenous colitis susceptibility loci. ( 25718298 )
2015
23
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. ( 26525574 )
2015
24
Microscopic (collagenous) colitis in a patient with a heart transplant. ( 26115392 )
2015
25
Pseudomembranous variant of collagenous colitis. ( 26508688 )
2015
26
Severe acute kidney injury as a complication of collagenous colitis. ( 26561416 )
2015
27
Collagenous colitis associated with protein losing enteropathy in a toddler. ( 25221677 )
2014
28
Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. ( 24440672 )
2014
29
Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222. ( 25164577 )
2014
30
Narrow band imaging for diagnosis of collagenous colitis. ( 25092202 )
2014
31
An In Vitro Model to Evaluate the Impact of the Soluble Factors from the Colonic Mucosa of Collagenous Colitis Patients on T Cells: Enhanced Production of IL-17A and IL-10 from Peripheral CD4(+) T Cells. ( 25332518 )
2014
32
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. ( 24526204 )
2014
33
Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial. ( 25425655 )
2014
34
Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. ( 25036565 )
2014
35
Acute onset collagenous colitis with unique endoscopic findings. ( 25610672 )
2014
36
Mucosal tears and colonic perforation in a patient with collagenous colitis. ( 24523187 )
2014
37
Clinical characteristics of collagenous colitis with linear ulcerations. ( 23560988 )
2014
38
O-018a88genome-wide association identifies multiple collagenous colitis susceptibility Loci. ( 25407172 )
2014
39
Collagenous colitis during treatment with fumaric acid esters. ( 25482705 )
2014
40
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. ( 23539406 )
2013
41
Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis. ( 23423580 )
2013
42
Stable incidence of collagenous colitis and lymphocytic colitis in A9rebro, Sweden, 1999-2008: a continuous epidemiologic study. ( 23945183 )
2013
43
Collagenous colitis in children and adolescents: study of 7 cases and literature review. ( 23348901 )
2013
44
Protein-losing enteropathy associated with collagenous colitis cured by withdrawal of a proton pump inhibitor. ( 23728552 )
2013
45
Lack of effect of methotrexate in budesonide-refractory collagenous colitis. ( 24039441 )
2013
46
Collagenous colitis with mucosal tears in two proton pump inhibitors and non-steroidal naive patients who developed metachronous cancer. ( 23134231 )
2013
47
Clinical features and treatment responses in pediatric lymphocytic and collagenous colitis. ( 23820404 )
2013
48
Celiac disease and other autoimmune diseases in patients with collagenous colitis. ( 23800241 )
2013
49
Cerebral demyelination in children with collagenous colitis. ( 23793315 )
2013
50
Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. ( 22658854 )
2013

Variations for Collagenous Colitis

Expression for Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for Collagenous Colitis

GO Terms for Collagenous Colitis

Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 CHGA COL14A1 EPX MPO RNASE3 SCG2
2 extracellular region GO:0005576 9.5 CHGA CHGB COL14A1 EPX MPO RNASE3
3 endoplasmic reticulum lumen GO:0005788 9.43 CHGB COL14A1 SCG2
4 secretory granule GO:0030141 8.92 CHGA CHGB MPO SCG2

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 9.37 CHGA RNASE3
2 defense response to Gram-negative bacterium GO:0050829 9.32 CHGA NOS2
3 defense response to fungus GO:0050832 9.26 CHGA MPO
4 innate immune response in mucosa GO:0002227 9.16 NOS2 RNASE3
5 hydrogen peroxide catabolic process GO:0042744 8.96 EPX MPO
6 defense response to bacterium GO:0042742 8.92 CHGA MPO NOS2 RNASE3

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX MPO
2 heme binding GO:0020037 8.8 EPX MPO NOS2

Sources for Collagenous Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....