MCID: CLL021
MIFTS: 58

Collagenous Colitis malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Collagenous Colitis

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NIH Rare Diseases:42 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as microscopic colitis, collagenous type, is related to colitis and inflammatory bowel disease. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Leishmaniasis and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds thiocyanate and budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related mouse phenotypes are skeleton and cardiovascular system.

Disease Ontology:8 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:65 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Aliases & Classifications for Collagenous Colitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Collagenous Colitis, Aliases & Descriptions:

Name: Collagenous Colitis 8 42 44 48
Microscopic Colitis, Collagenous Type 42
 
Colitis, Collagenous 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
collagenous colitis:
Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:0060183
ICD9CM27 558.9
MeSH34 D046729
MESH via Orphanet35 D046729
ICD10 via Orphanet26 K52.8
UMLS via Orphanet63 C0238067

Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1colitis32.4LTF, NOD2, NOS2, MPO
2inflammatory bowel disease31.1CD79A, MPO
3diarrhea31.1CHGA, CD79A, LTF
4food allergy31.0RNASE3, EPX
5spondylitis30.9NOD2
6ileitis30.8MPO, NOD2
7polyarteritis nodosa30.7LTF, MPO
8proctitis30.6LTF, EPX, RNASE3
9psoriatic arthritis30.6MMP1, NOD2
10gastritis30.6LTF, CD79A, NOS2, CHGA
11ulcerative colitis30.6MPO, RNASE3, EPX, MMP1, NOS2, NOD2
12ankylosing spondylitis30.6NOD2, CD79A, CD40LG
13lupus erythematosus30.5APOH, CD79A, CD40LG
14arthritis30.3MPO, TIMP1, MMP9, MMP1, NOS2, NOD2
15hepatitis c30.2TIMP1, MMP1, CD40LG, LTF
16systemic lupus erythematosus30.0APOH, MPO, NOD2, CD79A, CD40LG, LTF
17pulmonary fibrosis30.0MPO, TIMP1, MMP9, MMP1, CTGF
18rheumatoid arthritis28.9SCG2, APOH, MPO, TIMP1, RNASE3, MMP9
19lymphocytic colitis10.7
20chronic rhinitis10.6RNASE3
21eosinophil peroxidase deficiency10.6EPX
22toxocariasis10.6RNASE3
23cryptosporidiosis10.6CD79A
24mononeuropathy10.6MPO
25urethritis10.6CD79A
26chickenpox10.5CD79A
27retinal vasculitis10.5APOH
28q fever10.5CD79A
29microscopic colitis10.5
30systemic scleroderma10.5CTGF
31lactose intolerance10.5LTF
32keratoconjunctivitis sicca10.5LTF
33macroglobulinemia10.5CD79A
34endocarditis10.5EPX
35blepharitis10.5LTF
36purpura10.5CD79A
37periodontitis10.5MMP9
38oral candidiasis10.5LTF
39onchocerciasis10.5RNASE3, EPX
40asthma10.5RNASE3, EPX
41blindness10.5
42pulmonary eosinophilia10.5RNASE3, EPX
43syphilis10.5APOH, CD79A
44hypersensitivity vasculitis10.5MPO, CD79A
45giant papillary conjunctivitis10.4RNASE3, LTF
46toxoplasmosis10.4CD40LG, CD79A
47myxedema10.4TG
48congenital toxoplasmosis10.4CD40LG, CD79A
49conjunctivitis10.4RNASE3, CD79A
50immunoglobulin g deficiency10.4CD79A, CD40LG

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Drug clinical trials:

Search ClinicalTrials for Collagenous Colitis

Search NIH Clinical Center for Collagenous Colitis

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

32
Colon, Small intestine, T cells, Endothelial, Liver

Animal Models for Collagenous Colitis or affiliated genes

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MGI Mouse Phenotypes related to Collagenous Colitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CTGF, CD40LG, NOD2, NOS2, COL14A1, MMP9
2MP:00053858.1MPO, TIMP1, MMP9, CHGA, NOS2, CD40LG
3MP:00107687.5APOH, MPO, TIMP1, MMP9, CHGA, NOS2
4MP:00053877.4MMP9, EPX, TIMP1, MPO, MMP1, NOS2
5MP:00053797.4TIMP1, TG, CHGB, CHGA, NOS2, CD40LG
6MP:00053977.3MPO, TIMP1, TG, EPX, MMP9, NOS2
7MP:00053765.4LTF, APOH, MPO, TIMP1, TG, MMP9

Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. (24526204)
2014
2
Collagenous colitis associated with protein losing enteropathy in a toddler. (25221677)
2014
3
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
4
Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. (23200274)
2013
5
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
6
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010. (22719191)
2012
7
Is smoking a risk factor for collagenous colitis? (21854096)
2011
8
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study. (21557718)
2011
9
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
10
Mucosal scars in collagenous colitis. (20105482)
2010
11
Mucosal tear in collagenous colitis. (18691941)
2009
12
Interventions for treating collagenous colitis. (18425892)
2008
13
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
14
Colonic perforation as a complication of collagenous colitis in a series of 12 patients. (18702648)
2008
15
Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis. (18513560)
2008
16
Collagenous colitis: oral low-dose methotrexate for patients with difficult symptoms: long-term outcomes. (17845686)
2007
17
Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. (17718794)
2007
18
Collagenous colitis in adult Sri Lankans: experience from the Indian subcontinent. (16474114)
2006
19
Colonic mucosal tears in collagenous colitis. (16716973)
2006
20
Long-term follow-up of collagenous colitis after induction of clinical remission with budesonide. (16305725)
2005
21
Interventions for treating collagenous colitis: a Cochrane Inflammatory Bowel Disease Group systematic review of randomized trials. (15571596)
2004
22
Collagenous colitis with spondyloarthropathy presenting as fibromyalgia syndrome. (15229969)
2004
23
Fractured colon: an endoscopically distinctive lesion associated with colonic perforation following colonoscopy in patients with collagenous colitis. (15087693)
2004
24
Further report of familial occurrence of collagenous colitis. (12374242)
2002
25
Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. (11781276)
2002
26
Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis. (11569721)
2001
27
Collagenous colitis in an adult patient with chronic diarrhoea: case report. (12002091)
2001
28
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
29
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
30
Collagenous colitis: a long-term follow-up study. (10755251)
1999
31
Autoantibodies and immunoglobulins in collagenous colitis. (8881813)
1996
32
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
33
Olsalazine in collagenous colitis. (8031693)
1994
34
Collagenous colitis: an unusual endoscopic appearance. (8495846)
1993
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. (1361906)
1992
37
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
38
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990
39
Collagenous colitis. (2407439)
1990
40
Diarrhoea caused by collagenous colitis. (2774620)
1989
41
Collagenous colitis. (3337067)
1988
42
Increased subepithelial collagen deposition is not specific for collagenous colitis. (3237709)
1988
43
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
44
Collagenous colitis: an association with fecal leukocytes. (3230281)
1988
45
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
46
Collagenous colitis: physiologic and histopathologic studies in seven patients. (3789577)
1987
47
Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. (3610134)
1987
48
Collagenous colitis. (6524458)
1984
49
Collagenous colitis. Report of a case. (6697827)
1984
50
Collagenous colitis: the clinical and morphological features. (7122380)
1982

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Expression patterns in normal tissues for genes affiliated with Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CD40LG, NOD2, NOS2
29.7MMP1, TIMP1
39.6MMP1, MMP9
4
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.6MPO, TIMP1, NOS2
59.5CTGF, MMP9, MPO
6
Show member pathways
9.2MMP1, MMP9, TIMP1
7
Show member pathways
9.2MMP1, MMP9, TIMP1
8
Show member pathways
9.2TG, RNASE3, EPX, CD40LG
9
Show member pathways
8.9COL14A1, MMP1, MMP9, TIMP1
10
Show member pathways
8.7TIMP1, MMP9, MMP1, CD79A, CTGF

Compounds for genes affiliated with Collagenous Colitis

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Compounds related to Collagenous Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 238)
idCompoundScoreTop Affiliating Genes
1thiocyanate44 2410.7MPO, LTF, CD79A, EPX
2budesonide44 50 1111.5MPO, RNASE3, LTF, EPX
3gliadin449.4TG, RNASE3, CD40LG, CD79A
4minocycline44 1110.3TIMP1, MMP9, NOS2, LTF
5theophylline44 28 24 1112.2EPX, CD40LG, CD79A, CHGA, RNASE3
6endotoxin449.2NOS2, APOH, CD40LG, LTF, RNASE3, NOD2
7anti-fungal449.1CD40LG, CHGA, CD79A, RNASE3, LTF
8leukotriene b444 61 2411.1EPX, RNASE3, MPO, MMP9, LTF
9vitamin b12449.0MPO, APOH, CD40LG, LTF, TIMP1, CD79A
10ivig449.0MMP9, APOH, CD40LG, TG, CD79A
11procollagen448.9CTGF, COL14A1, MMP9, TIMP1, MMP1
12ribavirin44 50 1110.9TIMP1, MMP9, LTF, MMP1, CD40LG
13aspirin44 50 28 2411.9CD40LG, MMP1, RNASE3, TIMP1, APOH, CD79A
14alpha tocopherol448.7APOH, TIMP1, MMP9, MMP1, CTGF
15doxycycline44 119.7MMP9, CD40LG, CD79A, MMP1, TIMP1, LTF
16indomethacin44 28 61 1111.7LTF, MPO, TIMP1, MMP1, NOS2, CD79A
17p002448.6TIMP1, RNASE3, EPX, CHGA, CTGF, MMP9
18ascorbic acid44 249.5CD79A, MMP1, LTF, MPO, CD40LG, TG
19prednisolone44 28 1110.5MMP1, NOD2, CD79A, TG, MPO, APOH
20vitamin a44 24 1110.3TIMP1, TG, MMP9, MMP1, CD40LG, LTF
21formaldehyde44 249.3MMP9, MMP1, CHGA, CD79A, MPO, RNASE3
22rantes448.3TIMP1, CD40LG, MMP1, MMP9, SCG2, RNASE3
23nitric oxide44 24 1110.3NOD2, TIMP1, CHGA, RNASE3, MPO, EPX
24fibrinogen448.3CD79A, CD40LG, CTGF, APOH, LTF, CHGA
25hyaluronic acid44 249.2MMP9, CD79A, COL14A1, MMP1, RNASE3, TIMP1
26phorbol448.2TIMP1, CHGA, MMP1, MMP9, RNASE3
27epinephrine44 24 1110.2RNASE3, TG, MMP9, CD79A, MMP1, CHGA
28ribonucleic acid448.1TIMP1, CTGF, CHGA, MMP1, MMP9, TG
29acetylcholine44 50 28 24 1111.9NOS2, CHGA, RNASE3, TG, MPO, SCG2
30arginine447.9CD40LG, APOH, TIMP1, TG, CD79A, NOS2
31heparin44 28 24 1110.9CTGF, MPO, TG, RNASE3, CD40LG, EPX
32n acetylcysteine447.9NOS2, CD79A, CD40LG, CTGF, LTF, TIMP1
33h2o2447.8CTGF, TG, CD79A, LTF, MMP1, EPX
34cyclosporin a44 28 619.8MMP1, RNASE3, TG, TIMP1, CD79A, CD40LG
35histamine44 28 249.7EPX, SCG2, CD40LG, CD79A, CHGA, LTF
36cycloheximide447.7MMP9, TG, CTGF, NOS2, CHGA, MMP1
37pge2447.6MMP9, LTF, CTGF, CD40LG, CD79A, NOS2
38glutamate447.5APOH, TIMP1, TG, CHGA, CD79A, LTF
39paraffin447.4LTF, CD40LG, CHGA, MMP1, MMP9, TG
40adenylate447.3LTF, CD40LG, NOS2, CHGA, MMP9, TG
41retinoic acid44 248.0MMP1, TG, RNASE3, CHGA, TIMP1, CD40LG
42creatinine446.9MMP9, EPX, RNASE3, TG, MPO, APOH
43lactate446.9TIMP1, CTGF, MPO, APOH, MMP9, CHGA
44cysteine446.6CD79A, CHGA, CD40LG, CTGF, LTF, MMP1
45calcium44 50 24 119.4MPO, RNASE3, EPX, CHGA, APOH, SCG2
46norepinephrine44 24 118.3CHGB, TG, CHGA, CD79A, CD40LG, LTF
47serine446.2MMP9, CTGF, CD40LG, NOD2, CHGA, CHGB
48estrogen446.0LTF, CTGF, CD79A, NOS2, CHGA, CHGB
49dexamethasone44 50 28 118.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA
50vegf445.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA

GO Terms for genes affiliated with Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.1CTGF, COL14A1, MMP1, MMP9
2secretory granuleGO:0301417.8SCG2, MPO, CHGB, CHGA, LTF
3extracellular spaceGO:0056156.9SCG2, APOH, MPO, TG, MMP9, COL14A1
4extracellular regionGO:0055766.3LTF, TIMP1, TG, RNASE3, MMP9, MMP1

Biological processes related to Collagenous Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.0NOD2, MPO
2positive regulation of interleukin-12 productionGO:0327359.9CD40LG, NOD2
3hydrogen peroxide catabolic processGO:0427449.9MPO, EPX
4innate immune response in mucosaGO:0022279.9LTF, NOD2, NOS2
5defense response to bacteriumGO:0427429.9NOD2, NOS2, RNASE3
6ossificationGO:0015039.6MMP9, CTGF, LTF
7collagen catabolic processGO:0305749.5COL14A1, MMP1, MMP9
8extracellular matrix disassemblyGO:0226179.1COL14A1, MMP1, MMP9, TIMP1
9extracellular matrix organizationGO:0301989.0TIMP1, MMP9, MMP1, COL14A1
10negative regulation of apoptotic processGO:0430668.9LTF, CD40LG, TIMP1, MPO

Molecular functions related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxidase activityGO:00460110.0EPX, MPO
2heme bindingGO:0200379.5NOS2, EPX, MPO
3heparin bindingGO:0082019.3LTF, CTGF, MPO, APOH

Products for genes affiliated with Collagenous Colitis

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Sources for Collagenous Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet