MCID: CLL021
MIFTS: 45

Collagenous Colitis malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Collagenous Colitis:

Name: Collagenous Colitis 10 45 47 12 51
Colitis, Collagenous 36 65
 
Microscopic Colitis, Collagenous Type 45

Characteristics:

Orphanet epidemiological data:

51
collagenous colitis:
Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Sweden),1-9/1000000 (France),1-9/100000 (United States),1-9/100000 (Spain),1-9/100000 (Iceland),1-9/100000 (Canada); Age of onset: Adult,Elderly; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology10 DOID:0060183
ICD1027 K52.89
MeSH36 D046729
NCIt42 C27021
SNOMED-CT59 19311003
Orphanet51 36205
ICD10 via Orphanet28 K52.8
MESH via Orphanet37 D046729
UMLS via Orphanet66 C0238067
UMLS65 C0238067

Summaries for Collagenous Colitis

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NIH Rare Diseases:45 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as colitis, collagenous, is related to cystitis and ischemic colitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways are FSH signaling pathway and TSH signaling pathway. Affiliated tissues include colon, lung and liver, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:10 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:68 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1cystitis30.0CD79A, RNASE3
2ischemic colitis29.1CD79A, LTF, MPO
3lymphocytic colitis26.7CD79A, CHGA, CHGB, COL14A1, LTF, MPO
4colitis11.0
5microscopic colitis10.7
6collagenous gastritis10.5
7timothy grass allergy10.5MPO, RNASE3
8chronic sphenoidal sinusitis10.5MPO, RNASE3
9balkan nephropathy10.4MPO, RNASE3
10anterior dislocation of lens10.4LTF, RNASE3
11papillary conjunctivitis10.4LTF, RNASE3
12egg allergy10.3CD79A, RNASE3
13choroid plexus meningioma10.3CD79A, MPO
14generalized atherosclerosis10.3CD79A, MPO
15exudative glomerulonephritis10.3CD79A, MPO
16angioedema10.3CD79A, MPO
17diffuse secondary choroid atrophy10.3CD79A, MPO
18crescentic glomerulonephritis10.3CD79A, MPO
19hypersensitivity vasculitis10.3CD79A, MPO
20hemosiderosis10.2CD79A, MPO
21goat milk allergy10.2CD79A, RNASE3
22bronchial neoplasm10.2CD79A, MPO
23focal embolic glomerulonephritis10.2CD79A, MPO
24cervical incompetence10.2CD79A, MPO
25melorheostosis10.2CD79A, RNASE3
26ulcerative colitis10.2
27enamel caries10.2CD79A, RNASE3
28legionellosis10.2CD79A, NOS2
29acalculous cholecystitis10.2CD79A, RNASE3
30arthritis10.2
31trachoma10.2CD79A, NOS2
32villonodular synovitis10.2CD79A, MPO
33diarrhea10.2
34meckel's diverticulum10.2CD79A, LTF
35postcholecystectomy syndrome10.2CD79A, RNASE3
36intestinal botulism10.1CD79A, LTF
37hodgkin's lymphoma, nodular sclerosis10.1CD79A, RNASE3
38paralytic squint10.1CD79A, LTF
39shigellosis10.1CD79A, LTF
40anus disease10.1LTF, MPO, RNASE3
41chronic conjunctivitis10.1CD79A, LTF
42otomycosis10.1CD79A, LTF
43crohn's colitis10.0
44protein-losing enteropathy10.0
45post-traumatic stress disorder10.0CD79A, MPO, RNASE3
46qualitative platelet defect10.0CD79A, MPO, RNASE3
47glucose-6-phosphate translocase deficiency10.0CHGA, CHGB
48rheumatoid arthritis9.9
49celiac disease9.9
50crohn's disease9.9

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BudesonideapprovedPhase 338151333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide Inhalation
Budesonide MMX
Budesonide Nasal
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
 
Horacort
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort FLEXHALER
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Uceris
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
2Anti-Asthmatic AgentsPhase 32796
3Respiratory System AgentsPhase 33931
4Analgesics, Non-NarcoticPhase 35184
5Anti-Inflammatory Agents, Non-SteroidalPhase 33549
6Antirheumatic AgentsPhase 38496
7Peripheral Nervous System AgentsPhase 318510
8MesalaminePhase 315289-57-6
9AnalgesicsPhase 39358
10Bronchodilator AgentsPhase 32377
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 39988
12glucocorticoidsPhase 33896
13Anti-Inflammatory AgentsPhase 38478
14HormonesPhase 311748
15Hormone AntagonistsPhase 310002
16Pharmaceutical Solutions7004
17Gastrointestinal Agents6401
18
Bismuth1037440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
19Anti-Ulcer Agents1453
20Antacids1453
21ColaNutraceutical1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Budesonide for Maintenance Treatment of Collagenous ColitisCompletedNCT00180076Phase 3
2SOIBD Collagenous Colitis Maintenance StudyCompletedNCT01278082Phase 3
3Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous ColitisCompletedNCT00450086Phase 3
4Long-Term Treatment of Collagenous Colitis With BudesonideActive, not recruitingNCT00139165Phase 3
5Usefulness of Chromoendoscopy in Diagnosing Microscopic ColitisRecruitingNCT01504048
6Case-Control Study to Identify Risk Factors for Microscopic ColitisEnrolling by invitationNCT01928667
7Treatment of Microscopic ColitisTerminatedNCT00184171

Search NIH Clinical Center for Collagenous Colitis


Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

33
Colon, Lung, Liver, Prostate, T cells, Skin, Breast

Animal Models for Collagenous Colitis or affiliated genes

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MGI Mouse Phenotypes related to Collagenous Colitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1CD79A, CHGA, CHGB, COL14A1, LTF, MPO

Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50)    (show all 428)
idTitleAuthorsYear
1
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. (26019474)
2015
2
Collagenous colitis during treatment with fumaric acid esters. (25482705)
2014
3
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. (24526204)
2014
4
Acute onset collagenous colitis with unique endoscopic findings. (25610672)
2014
5
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
6
Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. (23200274)
2013
7
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
8
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010. (22719191)
2012
9
Is smoking a risk factor for collagenous colitis? (21854096)
2011
10
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
11
Mucosal scars in collagenous colitis. (20105482)
2010
12
Mucosal tear in collagenous colitis. (18691941)
2009
13
Interventions for treating collagenous colitis. (18425892)
2008
14
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
15
Colonic perforation as a complication of collagenous colitis in a series of 12 patients. (18702648)
2008
16
Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis. (18513560)
2008
17
Collagenous colitis: oral low-dose methotrexate for patients with difficult symptoms: long-term outcomes. (17845686)
2007
18
Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. (17718794)
2007
19
Collagenous colitis in adult Sri Lankans: experience from the Indian subcontinent. (16474114)
2006
20
Long-term follow-up of collagenous colitis after induction of clinical remission with budesonide. (16305725)
2005
21
Interventions for treating collagenous colitis: a Cochrane Inflammatory Bowel Disease Group systematic review of randomized trials. (15571596)
2004
22
Collagenous colitis with spondyloarthropathy presenting as fibromyalgia syndrome. (15229969)
2004
23
Fractured colon: an endoscopically distinctive lesion associated with colonic perforation following colonoscopy in patients with collagenous colitis. (15087693)
2004
24
Further report of familial occurrence of collagenous colitis. (12374242)
2002
25
Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. (11781276)
2002
26
Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis. (11569721)
2001
27
Collagenous colitis in an adult patient with chronic diarrhoea: case report. (12002091)
2001
28
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
29
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
30
Collagenous colitis: a long-term follow-up study. (10755251)
1999
31
Autoantibodies and immunoglobulins in collagenous colitis. (8881813)
1996
32
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
33
Olsalazine in collagenous colitis. (8031693)
1994
34
Collagenous colitis: an unusual endoscopic appearance. (8495846)
1993
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. (1361906)
1992
37
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
38
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990
39
Collagenous colitis. (2407439)
1990
40
Diarrhoea caused by collagenous colitis. (2774620)
1989
41
Collagenous colitis. (3337067)
1988
42
Increased subepithelial collagen deposition is not specific for collagenous colitis. (3237709)
1988
43
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
44
Collagenous colitis: an association with fecal leukocytes. (3230281)
1988
45
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
46
Collagenous colitis: physiologic and histopathologic studies in seven patients. (3789577)
1987
47
Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. (3610134)
1987
48
Collagenous colitis. (6524458)
1984
49
Collagenous colitis. Report of a case. (6697827)
1984
50
Collagenous colitis: the clinical and morphological features. (7122380)
1982

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3CHGA, RNASE3
29.3CHGA, RNASE3
3
Show member pathways
9.0CHGA, NOS2, RNASE3

GO Terms for genes affiliated with Collagenous Colitis

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Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell redox homeostasisGO:00454549.6LTF, NOS2
2defense response to Gram-positive bacteriumGO:00508309.5CHGA, RNASE3
3innate immune response in mucosaGO:00022279.3LTF, NOS2
4defense response to Gram-negative bacteriumGO:00508299.2CHGA, NOS2

Sources for Collagenous Colitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet