MCID: CLL021
MIFTS: 57

Collagenous Colitis malady

Rare diseases, Gastrointestinal diseases categories

Summaries for Collagenous Colitis

About this section


NIH Rare Diseases:43 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as microscopic colitis, collagenous type, is related to colitis and diarrhea. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Leishmaniasis and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds thiocyanate and budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related mouse phenotypes are skeleton and cardiovascular system.

Disease Ontology:10 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:65 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Aliases & Classifications for Collagenous Colitis

About this section
Sources:
10Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 29ICD9CM, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Collagenous Colitis, Aliases & Descriptions:

Name: Collagenous Colitis 10 43 45 49
Microscopic Colitis, Collagenous Type 43
 
Colitis, Collagenous 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

49
collagenous colitis:
Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Sweden),1-9/1000000 (France),1-9/100000 (United States),1-9/100000 (Spain),1-9/100000 (Iceland),1-9/100000 (Canada); Age of onset: Adult,Elderly; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:0060183
ICD9CM29 558.9
MeSH35 D046729
Orphanet49 36205
MESH via Orphanet36 D046729
ICD10 via Orphanet28 K52.8
UMLS via Orphanet63 C0238067

Related Diseases for Collagenous Colitis

About this section

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1colitis32.1LTF, NOD2, NOS2, MPO
2diarrhea30.9CHGA, CD79A, LTF
3ulcerative colitis30.8MPO, RNASE3, EPX, MMP1, NOS2, NOD2
4arthritis30.8MPO, TIMP1, MMP9, MMP1, NOS2, NOD2
5inflammatory bowel disease30.5CD79A, MPO
6gastritis30.4LTF, CD79A, NOS2, CHGA
7food allergy30.4RNASE3, EPX
8lupus erythematosus30.4APOH, CD79A, CD40LG
9psoriatic arthritis30.3MMP1, NOD2
10rheumatoid arthritis30.3SCG2, APOH, MPO, TIMP1, RNASE3, MMP9
11systemic lupus erythematosus30.3APOH, MPO, NOD2, CD79A, CD40LG, LTF
12spondylitis30.2NOD2
13ileitis30.2MPO, NOD2
14polyarteritis nodosa30.2LTF, MPO
15proctitis30.1LTF, EPX, RNASE3
16hepatitis c30.1TIMP1, MMP1, CD40LG, LTF
17pulmonary fibrosis30.1MPO, TIMP1, MMP9, MMP1, CTGF
18lymphocytic colitis10.7
19microscopic colitis10.6
20blindness10.5
21crohn's disease10.4
22crohn's colitis10.4
23protein-losing enteropathy10.4
24pyoderma gangrenosum10.4
25pyoderma10.4
26celiac disease10.3
27collagenous gastritis10.3
28common variable immunodeficiency10.2
29toxic megacolon10.2
30amyloidosis10.2
31hyperparathyroidism10.2
32megacolon10.2
33spondyloarthropathy10.2
34spondylarthropathy10.2
35endotheliitis10.2
36chronic rhinitis10.1RNASE3
37eosinophil peroxidase deficiency10.1EPX
38toxocariasis10.1RNASE3
39cryptosporidiosis10.1CD79A
40mononeuropathy10.1MPO
41urethritis10.1CD79A
42chickenpox10.1CD79A
43retinal vasculitis10.1APOH
44q fever10.1CD79A
45systemic scleroderma10.1CTGF
46lactose intolerance10.1LTF
47keratoconjunctivitis sicca10.1LTF
48macroglobulinemia10.1CD79A
49endocarditis10.1EPX
50blepharitis10.1LTF

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

About this section

Drugs & Therapeutics for Collagenous Colitis

About this section

Drug clinical trials:

Search ClinicalTrials for Collagenous Colitis

Search NIH Clinical Center for Collagenous Colitis

Genetic Tests for Collagenous Colitis

About this section

Anatomical Context for Collagenous Colitis

About this section

MalaCards organs/tissues related to Collagenous Colitis:

33
Colon, Small intestine, T cells, Endothelial, Liver

Animal Models for Collagenous Colitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Collagenous Colitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CTGF, CD40LG, NOD2, NOS2, COL14A1, MMP9
2MP:00053858.1MPO, TIMP1, MMP9, CHGA, NOS2, CD40LG
3MP:00107687.5APOH, MPO, TIMP1, MMP9, CHGA, NOS2
4MP:00053877.4MMP9, EPX, TIMP1, MPO, MMP1, NOS2
5MP:00053797.4TIMP1, TG, CHGB, CHGA, NOS2, CD40LG
6MP:00053977.3MPO, TIMP1, TG, EPX, MMP9, NOS2
7MP:00053765.4LTF, APOH, MPO, TIMP1, TG, MMP9

Publications for Collagenous Colitis

About this section

Articles related to Collagenous Colitis:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Collagenous colitis during treatment with fumaric acid esters. (25482705)
2014
2
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. (24526204)
2014
3
Acute onset collagenous colitis with unique endoscopic findings. (25610672)
2014
4
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
5
Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. (23200274)
2013
6
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
7
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010. (22719191)
2012
8
Is smoking a risk factor for collagenous colitis? (21854096)
2011
9
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study. (21557718)
2011
10
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
11
Mucosal scars in collagenous colitis. (20105482)
2010
12
Mucosal tear in collagenous colitis. (18691941)
2009
13
Interventions for treating collagenous colitis. (18425892)
2008
14
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
15
Colonic perforation as a complication of collagenous colitis in a series of 12 patients. (18702648)
2008
16
Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis. (18513560)
2008
17
Collagenous colitis: oral low-dose methotrexate for patients with difficult symptoms: long-term outcomes. (17845686)
2007
18
Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. (17718794)
2007
19
Collagenous colitis in adult Sri Lankans: experience from the Indian subcontinent. (16474114)
2006
20
Long-term follow-up of collagenous colitis after induction of clinical remission with budesonide. (16305725)
2005
21
Interventions for treating collagenous colitis: a Cochrane Inflammatory Bowel Disease Group systematic review of randomized trials. (15571596)
2004
22
Collagenous colitis with spondyloarthropathy presenting as fibromyalgia syndrome. (15229969)
2004
23
Fractured colon: an endoscopically distinctive lesion associated with colonic perforation following colonoscopy in patients with collagenous colitis. (15087693)
2004
24
Further report of familial occurrence of collagenous colitis. (12374242)
2002
25
Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. (11781276)
2002
26
Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis. (11569721)
2001
27
Collagenous colitis in an adult patient with chronic diarrhoea: case report. (12002091)
2001
28
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
29
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
30
Collagenous colitis: a long-term follow-up study. (10755251)
1999
31
Autoantibodies and immunoglobulins in collagenous colitis. (8881813)
1996
32
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
33
Olsalazine in collagenous colitis. (8031693)
1994
34
Collagenous colitis: an unusual endoscopic appearance. (8495846)
1993
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. (1361906)
1992
37
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
38
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990
39
Collagenous colitis. (2407439)
1990
40
Diarrhoea caused by collagenous colitis. (2774620)
1989
41
Collagenous colitis. (3337067)
1988
42
Increased subepithelial collagen deposition is not specific for collagenous colitis. (3237709)
1988
43
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
44
Collagenous colitis: an association with fecal leukocytes. (3230281)
1988
45
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
46
Collagenous colitis: physiologic and histopathologic studies in seven patients. (3789577)
1987
47
Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. (3610134)
1987
48
Collagenous colitis. (6524458)
1984
49
Collagenous colitis. Report of a case. (6697827)
1984
50
Collagenous colitis: the clinical and morphological features. (7122380)
1982

Variations for Collagenous Colitis

About this section

Expression for genes affiliated with Collagenous Colitis

About this section

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

About this section

Pathways related to Collagenous Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CD40LG, NOD2, NOS2
29.7MMP1, TIMP1
39.6MMP1, MMP9
4
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.6MPO, TIMP1, NOS2
59.5CTGF, MMP9, MPO
6
Show member pathways
9.2MMP1, MMP9, TIMP1
7
Show member pathways
9.2MMP1, MMP9, TIMP1
8
Show member pathways
9.2TG, RNASE3, EPX, CD40LG
9
Show member pathways
8.9COL14A1, MMP1, MMP9, TIMP1
10
Show member pathways
8.7TIMP1, MMP9, MMP1, CD79A, CTGF

Compounds for genes affiliated with Collagenous Colitis

About this section

Compounds related to Collagenous Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 238)
idCompoundScoreTop Affiliating Genes
1thiocyanate45 2610.7MPO, LTF, CD79A, EPX
2budesonide45 51 1311.5MPO, RNASE3, LTF, EPX
3gliadin459.4TG, RNASE3, CD40LG, CD79A
4minocycline45 1310.3TIMP1, MMP9, NOS2, LTF
5theophylline45 30 26 1312.2EPX, CD40LG, CD79A, CHGA, RNASE3
6endotoxin459.2NOS2, APOH, CD40LG, LTF, RNASE3, NOD2
7anti-fungal459.1CD40LG, CHGA, CD79A, RNASE3, LTF
8leukotriene b445 61 2611.1EPX, RNASE3, MPO, MMP9, LTF
9vitamin b12459.0MPO, APOH, CD40LG, LTF, TIMP1, CD79A
10ivig459.0MMP9, APOH, CD40LG, TG, CD79A
11procollagen458.9CTGF, COL14A1, MMP9, TIMP1, MMP1
12ribavirin45 51 1310.9TIMP1, MMP9, LTF, MMP1, CD40LG
13aspirin45 51 30 2611.9CD40LG, MMP1, RNASE3, TIMP1, APOH, CD79A
14alpha tocopherol458.7APOH, TIMP1, MMP9, MMP1, CTGF
15doxycycline45 139.7MMP9, CD40LG, CD79A, MMP1, TIMP1, LTF
16indomethacin45 30 61 1311.7LTF, MPO, TIMP1, MMP1, NOS2, CD79A
17p002458.6TIMP1, RNASE3, EPX, CHGA, CTGF, MMP9
18ascorbic acid45 269.5CD79A, MMP1, LTF, MPO, CD40LG, TG
19prednisolone45 30 1310.5MMP1, NOD2, CD79A, TG, MPO, APOH
20vitamin a45 26 1310.3TIMP1, TG, MMP9, MMP1, CD40LG, LTF
21formaldehyde45 269.3MMP9, MMP1, CHGA, CD79A, MPO, RNASE3
22rantes458.3TIMP1, CD40LG, MMP1, MMP9, SCG2, RNASE3
23nitric oxide45 26 1310.3NOD2, TIMP1, CHGA, RNASE3, MPO, EPX
24fibrinogen458.3CD79A, CD40LG, CTGF, APOH, LTF, CHGA
25hyaluronic acid45 269.2MMP9, CD79A, COL14A1, MMP1, RNASE3, TIMP1
26phorbol458.2TIMP1, CHGA, MMP1, MMP9, RNASE3
27epinephrine45 26 1310.2RNASE3, TG, MMP9, CD79A, MMP1, CHGA
28ribonucleic acid458.1TIMP1, CTGF, CHGA, MMP1, MMP9, TG
29acetylcholine45 51 30 26 1311.9NOS2, CHGA, RNASE3, TG, MPO, SCG2
30arginine457.9CD40LG, APOH, TIMP1, TG, CD79A, NOS2
31heparin45 30 26 1310.9CTGF, MPO, TG, RNASE3, CD40LG, EPX
32n acetylcysteine457.9NOS2, CD79A, CD40LG, CTGF, LTF, TIMP1
33h2o2457.8CTGF, TG, CD79A, LTF, MMP1, EPX
34cyclosporin a45 30 619.8MMP1, RNASE3, TG, TIMP1, CD79A, CD40LG
35histamine45 30 269.7EPX, SCG2, CD40LG, CD79A, CHGA, LTF
36cycloheximide457.7MMP9, TG, CTGF, NOS2, CHGA, MMP1
37pge2457.6MMP9, LTF, CTGF, CD40LG, CD79A, NOS2
38glutamate457.5APOH, TIMP1, TG, CHGA, CD79A, LTF
39paraffin457.4LTF, CD40LG, CHGA, MMP1, MMP9, TG
40adenylate457.3LTF, CD40LG, NOS2, CHGA, MMP9, TG
41retinoic acid45 268.0MMP1, TG, RNASE3, CHGA, TIMP1, CD40LG
42creatinine456.9MMP9, EPX, RNASE3, TG, MPO, APOH
43lactate456.9TIMP1, CTGF, MPO, APOH, MMP9, CHGA
44cysteine456.6CD79A, CHGA, CD40LG, CTGF, LTF, MMP1
45calcium45 51 26 139.4MPO, RNASE3, EPX, CHGA, APOH, SCG2
46norepinephrine45 26 138.3CHGB, TG, CHGA, CD79A, CD40LG, LTF
47serine456.2MMP9, CTGF, CD40LG, NOD2, CHGA, CHGB
48estrogen456.0LTF, CTGF, CD79A, NOS2, CHGA, CHGB
49dexamethasone45 51 30 138.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA
50vegf455.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA

GO Terms for genes affiliated with Collagenous Colitis

About this section

Cellular components related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.1CTGF, COL14A1, MMP1, MMP9
2secretory granuleGO:00301417.8SCG2, MPO, CHGB, CHGA, LTF
3extracellular spaceGO:00056156.9SCG2, APOH, MPO, TG, MMP9, COL14A1
4extracellular regionGO:00055766.3LTF, TIMP1, TG, RNASE3, MMP9, MMP1

Biological processes related to Collagenous Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:004413010.0NOD2, MPO
2positive regulation of interleukin-12 productionGO:00327359.9CD40LG, NOD2
3hydrogen peroxide catabolic processGO:00427449.9MPO, EPX
4innate immune response in mucosaGO:00022279.9LTF, NOD2, NOS2
5defense response to bacteriumGO:00427429.9NOD2, NOS2, RNASE3
6ossificationGO:00015039.6MMP9, CTGF, LTF
7collagen catabolic processGO:00305749.5COL14A1, MMP1, MMP9
8extracellular matrix disassemblyGO:00226179.1COL14A1, MMP1, MMP9, TIMP1
9extracellular matrix organizationGO:00301989.0TIMP1, MMP9, MMP1, COL14A1
10negative regulation of apoptotic processGO:00430668.9LTF, CD40LG, TIMP1, MPO

Molecular functions related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxidase activityGO:000460110.0EPX, MPO
2heme bindingGO:00200379.5NOS2, EPX, MPO
3heparin bindingGO:00082019.3LTF, CTGF, MPO, APOH

Products for genes affiliated with Collagenous Colitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Collagenous Colitis

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet