MCID: CLL021
MIFTS: 41

Collagenous Colitis malady

Gastrointestinal diseases category

Summaries for Collagenous Colitis

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards: Collagenous Colitis, also known as microscopic colitis, collagenous type, is related to ulcerative colitis and arthritis. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Syndecan-1-mediated signaling events and amb2 Integrin signaling. The compounds indomethacin and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:63 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Aliases & Classifications for Collagenous Colitis

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
collagenous colitis:
Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

collagenous colitis 42 44 48
microscopic colitis, collagenous type 42
colitis, collagenous 60


External Ids:

ICD10 via Orphanet26 K52.8
SNOMED-CT via Orphanet57 19311003
UMLS via Orphanet61 C0238067
MESH via Orphanet35 D046729

Related Diseases for Collagenous Colitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis30.8LTF, RNASE3, CD79A, NOD2, NOS2, MPO
2arthritis30.7MMP9, NOD2, MPO, MMP1, CTGF, TIMP1
3diarrhea30.7CD79A, LTF
4crohn's disease30.5MPO, NOD2
5pyoderma gangrenosum30.4NOD2
6rheumatoid arthritis30.4CD79A, RNASE3, MMP1, MPO, CD40LG, NOS2
7celiac disease30.3CD79A, TG
8gastritis30.3CD79A, LTF, NOS2
9inflammatory bowel disease30.3EPX, MPO, NOD2, NOS2, MMP1, LTF
10amyloidosis30.2CD79A
11lupus erythematosus30.2APOH, CD79A, CD40LG
12systemic lupus erythematosus30.2MPO, LTF, CD79A, NOD2, APOH, CD40LG
13spondylitis30.0NOD2
14irritable bowel syndrome30.0LTF
15hepatitis30.0CD40LG
16peritonitis30.0MPO, CTGF
17polyarteritis nodosa30.0MPO, LTF
18proctitis30.0RNASE3, EPX, LTF
19connective tissue disease30.0APOH, CTGF, LTF
20ankylosing spondylitis30.0NOD2, CD79A, CD40LG
21hepatitis c29.9LTF, TIMP1, CD40LG, MMP1
22pulmonary fibrosis29.9TIMP1, MMP9, MMP1, MPO, CTGF
23collagen disease10.8
24pyoderma10.3
25protein-losing enteropathy10.2
26toxic megacolon10.1
27common variable immunodeficiency10.1
28psoriatic arthritis10.1
29constipation10.1
30food allergy10.1
31hyperparathyroidism10.1
32megacolon10.1
33spondyloarthropathy10.1
34syndromic diarrhea10.0
35secretory diarrhea10.0
36sapho syndrome10.0
37cerebritis10.0
38eosinophilic gastritis10.0
39gastroduodenitis10.0
40duodenitis10.0
41osteogenesis imperfecta10.0
42addison's disease10.0
43colonic disease10.0
44cystitis10.0
45dermatomyositis10.0
46intestinal disease10.0
47nervous system disease10.0
48scleroderma10.0
49collagenous gastritis10.0
50lymphocytic colitis10.0

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Clinical Features for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Collagenous Colitis

Drug clinical trials:

Search ClinicalTrials for Collagenous Colitis

Search NIH Clinical Center for Collagenous Colitis

Search CenterWatch for Collagenous Colitis

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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32MalaCards
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MalaCards organs/tissues related to Collagenous Colitis:

32
Colon

Animal Models for Collagenous Colitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Collagenous Colitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5TG, NOD2, CD79A, CD40LG, LTF, CTGF
2MP:00053876.8NOS2, MMP9, EPX, CD79A, CD40LG, LTF
3MP:00053976.2EPX, CD79A, LTF, MMP9, NOS2, NOD2

Publications for Collagenous Colitis

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Genetic Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Collagenous Colitis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Collagenous Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 190)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.5LTF
2cardiolipin44 1111.2TG
3norepinephrine44 11 2412.1MMP1, LTF
4alpha tocopherol4410.1CTGF, APOH
5glutamate4410.0APOH, CD40LG
6endotoxin449.9RNASE3, LTF, APOH
7pge2449.8EPX, MMP9
8uva 1449.8MMP1, TIMP1
9acetylcholine44 49 28 11 2413.7NOS2, CD40LG, MPO
10budesonide44 49 1111.6RNASE3, EPX, LTF, MPO
11thiocyanate44 2410.4EPX, LTF, MPO, CD79A
12gliadin449.4CD40LG, CD79A, TG
13hypothiocyanite44 2410.3CD79A, LTF, MPO
14doxycycline44 1110.2LTF, CD79A, MMP1, CD40LG
15cytochalasin b449.2LTF, MPO, RNASE3, EPX
16epinephrine44 11 2411.1RNASE3, CD79A, TG, CD40LG
17ivig449.1TG, APOH, CD79A, CD40LG
18methacholine44 1110.1MPO, LTF, RNASE3, CD79A
19estrogen448.9TG, RNASE3, CD79A, APOH, LTF
20minocycline44 119.9NOS2, LTF, TIMP1, MMP9
21h2o2448.8MMP1, EPX, LTF, MPO, CTGF, CD79A
22vitamin a44 11 2410.8MMP1, MMP9, LTF, TIMP1
23leukotriene b444 59 2410.8EPX, RNASE3, MMP9, LTF, MPO
24mannose448.5APOH, NOD2, LTF, CD79A, TG
25vitamin b12448.5APOH, CD79A, TIMP1, MPO, LTF, CD40LG
26aspirin44 49 28 2411.5RNASE3, TIMP1, MMP1, CD40LG, APOH, CD79A
27p002448.5APOH, TIMP1, EPX, RNASE3, MMP9, CTGF
28ribavirin44 49 1110.4TIMP1, LTF, CD40LG, MMP1, MMP9
29nitric oxide44 11 2410.4RNASE3, EPX, NOS2, NOD2, MPO, CTGF
30cytochalasin d44 599.4MMP9, MMP1, LTF, TIMP1, CTGF
31histamine44 28 2410.3CD79A, MPO, RNASE3, LTF, TIMP1, EPX
32herbimycin a44 599.3TIMP1, MMP1, MMP9, NOS2, CD40LG
33cyclosporin a44 28 5910.2CD79A, TG, MMP1, RNASE3, CD40LG, LTF
34ascorbic acid44 249.2CD40LG, LTF, MPO, CD79A, MMP1, NOS2
35prednisolone44 28 1110.2CD79A, EPX, RNASE3, MPO, APOH, MMP1
36formaldehyde44 249.0EPX, CD79A, CD40LG, MMP9, MMP1, MPO
37curcumin448.0NOS2, MMP9, MMP1, CTGF, TIMP1
38fibrinogen447.9CTGF, MMP9, RNASE3, APOH, CD79A, CD40LG
39heparin44 28 11 2410.8APOH, TIMP1, RNASE3, EPX, CD79A, CD40LG
40serine447.7LTF, EPX, MMP1, MPO, CTGF, MMP9
41adenylate447.7TIMP1, LTF, CD40LG, RNASE3, MMP9, NOS2
42creatinine447.5TG, MMP1, RNASE3, EPX, CD79A, LTF
43paraffin447.1TG, MMP9, MMP1, MPO, CD79A, CD40LG
44hyaluronic acid44 248.1TIMP1, RNASE3, MMP1, MMP9, LTF, CD40LG
45dexamethasone44 49 28 119.9CTGF, LTF, CD79A, EPX, RNASE3, NOS2
46n acetylcysteine446.9NOS2, RNASE3, TIMP1, CTGF, MPO, LTF
47cysteine446.8TG, MMP1, CD79A, CTGF, TIMP1, EPX
48retinoic acid44 247.6MMP9, RNASE3, LTF, CD40LG, CD79A, CTGF
49lactate446.5CD40LG, CD79A, EPX, RNASE3, MMP1, MMP9
50vegf446.1TIMP1, APOH, LTF, TG, CTGF, MPO

GO Terms for genes affiliated with Collagenous Colitis

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16Gene Ontology
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Cellular components related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055788.4MMP9, COL14A1, CTGF, MMP1
2extracellular spaceGO:0056157.1COL14A1, APOH, CTGF, MPO, CD40LG, MMP9
3extracellular regionGO:0055766.5TG, CTGF, COL14A1, MMP9, MMP1, TIMP1

Biological processes related to Collagenous Colitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:00222710.0NOD2, NOS2
2negative regulation of growth of symbiont in hostGO:0441309.9NOD2, MPO
3defense response to bacteriumGO:0427429.5NOD2, NOS2, LTF, RNASE3
4B cell proliferationGO:0421009.2CD79A, CD40LG
5collagen catabolic processGO:0305748.7COL14A1, MMP1, MMP9
6extracellular matrix disassemblyGO:0226178.4COL14A1, MMP9, MMP1, TIMP1
7extracellular matrix organizationGO:0301988.1COL14A1, TIMP1, MMP1, MMP9

Molecular functions related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.7NOS2, EPX, MPO
2heparin bindingGO:0082018.9LTF, MPO, CTGF, APOH

Products for genes affiliated with Collagenous Colitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Collagenous Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet