Collagenous Colitis malady

Wikipedia: Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak...⁴⁴ more...

MalaCards: Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and irritable bowel syndrome. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Asthma and Activation of Matrix Metalloproteinases. The compounds ivig and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include small intestine and colon, and related mouse phenotypes are hematopoietic system and immune system.

collagenous colitis 30 32 colitis, collagenous 43

Diseases related to collagenous colitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 411)

id	Related Disease	Score	Top Affiliating Genes
1	lymphocytic colitis	29.4	CD79A, NOS2
2	irritable bowel syndrome	27.8	MPO, CD79A, CD40LG, LTF, EPX
3	giant papillary conjunctivitis	13.5	RNASE3, LTF
4	eosinophil peroxidase deficiency	13.5	MPO, EPX
5	chronic maxillary sinusitis	13.4	MPO, RNASE3
6	urinary schistosomiasis	13.4	RNASE3, EPX
7	retinal vasculitis	13.4	APOH, NOS2
8	hemorrhagic shock and encephalopathy syndrome	13.4	MPO, NOS2
9	toxocariasis	13.3	CD40LG, RNASE3
10	asthma	13.3	RNASE3, EPX
11	crohn's disease	13.3	MPO, NOD2
12	transverse myelitis	13.3	CD40LG, APOH
13	mononeuropathy	13.3	MPO, APOH
14	colonic disease	13.3	NOD2, NOS2
15	chronic rhinitis	13.3	MPO, RNASE3, EPX
16	herpes gestationis	13.2	CD79A, RNASE3
17	allergic rhinitis	13.2	MPO, RNASE3, EPX
18	hypersensitivity vasculitis	13.2	MPO, CD79A
19	cystic fibrosis lung disease	13.2	MPO, NOS2, RNASE3
20	internal hemorrhoid	13.2	MMP9, NOS2
21	goodpasture syndrome	13.2	MPO, CD79A
22	cryofibrinogenemia	13.2	CD79A, CD40LG
23	choledochal cyst	13.2	MMP1, NOS2
24	catastrophic antiphospholipid syndrome	13.2	CD40LG, APOH
25	bronchitis	13.2	MPO, RNASE3, LTF
26	sneddon syndrome	13.2	CD79A, APOH
27	connective tissue disease	13.2	APOH, CTGF, LTF
28	lactose intolerance	13.2	CD79A, LTF
29	natural killer cell leukemia	13.2	MPO, CD79A
30	churg-strauss syndrome	13.1	MPO, RNASE3, LTF
31	congenital toxoplasmosis	13.1	CD79A, CD40LG
32	hemorrhoid	13.1	MMP9, NOS2
33	selective iga deficiency disease	13.1	CD79A, CD40LG
34	aggressive periodontitis	13.1	MMP1, LTF
35	immunodeficiency with hyper igm	13.1	CD79A, CD40LG
36	sporotrichosis	13.1	CD79A, CD40LG
37	secondary syphilis	13.1	CD79A, CD40LG
38	central nervous system disease	13.1	CD40LG, APOH, NOS2
39	immunodeficiency, centromere instability and facial anomalies syndrome	13.1	CD79A, CD40LG
40	ocular cicatricial pemphigoid	13.1	CD79A, CTGF, RNASE3
41	dandy-walker syndrome	13.1	CD79A, CD40LG
42	autoimmune disease of central nervous system	13.1	CD79A, CD40LG
43	immune-complex glomerulonephritis	13.1	MPO, CD40LG
44	nervous system disease	13.1	CD40LG, APOH, NOS2
45	portal hypertension	13.1	MPO, CTGF, NOS2
46	iritis	13.1	CD79A, CD40LG
47	immunoglobulin alpha deficiency	13.1	CD79A, CD40LG
48	cicatricial pemphigoid	13.1	CD79A, CTGF, RNASE3
49	immunodeficiency with hyper igm type 1	13.1	CD79A, CD40LG
50	nephrogenic systemic fibrosis	13.1	CTGF, TIMP1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to collagenous colitis:

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MGI Mouse Phenotypes related to collagenous colitis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.4	NOD2, TG, EPX
2	immune system phenotype	MP:0005387	9.0	CD79A, NOD2, LTF
3	homeostasis/metabolism phenotype	MP:0005376	5.7	TG, TIMP1, LTF, NOS2, NOD2, CTGF

Articles related to collagenous colitis:

(show all 13)

id	Title	Authors	Year	Affiliating Genes
1	Allelic variation of the matrix metalloproteinase-9 g ene is associated with collagenous colitis. (21305678)	Madisch A.... Miehlke S.	2011	MMP9
2	Connective tissue growth factor expression is increas ed in collagenous colitis and coeliac disease. (20840672)	GA1nther U.... Kaskas B.A.	2010	CTGF
3	NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis. (16804670)	Madisch A.... Miehlke S.	2007	NOD2
4	Metabolic and inflammatory faecal markers in collagenous colitis. (17556903)	Wildt S.... Rumessen J.J.	2007	LTF
5	Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis. (16373277)	LettesjAP H.... SimrAcn M.	2006	MPO, EPX
6	Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. (16957516)	Bonderup O.K.... Teglbjaerg P.S.	2006	NOS2
7	Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. (17109497)	Taha Y.... ThAPrn M.	2006	MPO, RNASE3
8	Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. (11511561)	Perner A.... Rask-Madsen J.	2001	NOS2
9	Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. (11330429)	Taha Y.... Raab Y.	2001	RNASE3
10	Fibrogenesis and fibrolysis in collagenous colitis. Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and -13, and TIMP-1 gene expression. (10433942)	Gunther U.... Herbst H.	1999	MMP1, TIMP1, COL14A1
11	Collagenous colitis associated with rheumatoid arthri tis and anticardiolipin antibodies. (9586689)	GA1naydin I.... Kanz L.	1998	APOH
12	Small intestine in lymphocytic and collagenous colitis: mucosal morphology, permeability, and secretory immunity to gliadin. (9378824)	Moayyedi P.... Axon A.T.	1997	CD40LG, CD79A
13	Autoantibodies and immunoglobulins in collagenous colitis. (8881813)	Bohr J.... JAornerot G.	1996	TG

Genes related to collagenous colitis according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
2	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
3	EPX	eosinophil peroxidase	11.0	Publications
4	CTGF	connective tissue growth factor	11.0	Publications
5	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
6	MPO	myeloperoxidase	11.0	Publications
7	LTF	lactotransferrin	11.0	Publications
8	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
9	COL14A1	collagen, type XIV, alpha 1	11.0	Publications
10	TG	thyroglobulin	11.0	Publications
11	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
12	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
13	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
14	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
15	CD40LG	CD40 ligand	11.0	Publications

Pathways related to collagenous colitis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Asthma20	9.5	EPX, RNASE3, CD40LG
2	Activation of Matrix Metalloproteinases38	9.0	TIMP1, MMP1, MMP9
3	Inhibition of Matrix Metalloproteinases36	8.9	TIMP1, MMP9, MMP1
4	Cell adhesion_ECM remodeling41	8.8	TIMP1, MMP9, MMP1
5	Pancreatic Adenocarcinoma36	8.6	TIMP1, CTGF, MMP9, MMP1
6	Cell adhesion ECM remodeling10	8.6	TIMP1, MMP9, MMP1

Compounds related to collagenous colitis according to GeneDecks:

(show top 50)    (show all 183)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.4	TG
2	endotoxin32	10.2	LTF, APOH
3	vitamin a32 9 18 9	13.1	TG, LTF
4	budesonide32 42 9 9	12.9	RNASE3, LTF, EPX
5	pge232	9.7	EPX, LTF, MMP1
6	ascorbic acid32 18	10.6	CD40LG, TG, LTF
7	hyaluronic acid32 18	10.4	MMP1, COL14A1, RNASE3, LTF
8	uva 132	9.3	RNASE3, TIMP1, MMP1
9	cytochalasin b32	9.3	EPX, RNASE3, LTF, MPO
10	minocycline32 9 9	11.3	TIMP1, NOS2, LTF, MMP9
11	thiocyanate32 18	10.2	CD79A, LTF, EPX, MPO
12	leukotriene b432 42 18	11.2	EPX, MPO, MMP9, RNASE3, LTF
13	hypothiocyanite32 18	10.0	CD79A, LTF, MPO
14	alpha tocopherol32	8.9	TIMP1, CTGF, MMP9, MMP1
15	latanoprost32 9 9	10.9	MMP1, MMP9, TIMP1
16	heparin32 9 18 9	11.8	MPO, CD79A, RNASE3, TIMP1, EPX
17	gliadin32	8.8	TG, CD40LG, RNASE3, CD79A
18	p00232	8.8	EPX, RNASE3, MMP9, APOH, CTGF, TIMP1
19	gluten32	8.8	CD79A, APOH, RNASE3
20	cardiolipin32 9 9	10.6	TG, APOH, CD40LG, CD79A
21	glutamate32	8.6	MMP9, TIMP1, APOH, CD79A
22	procollagen32	8.6	TIMP1, COL14A1, CTGF, MMP9, MMP1
23	h2o232	8.6	RNASE3, EPX, TG, LTF, MPO, CD79A
24	cytochalasin d32 42	9.5	LTF, CTGF, MMP9, MMP1, TIMP1
25	ribavirin32 34 9 9	11.4	MMP9, CD40LG, LTF, TIMP1, MMP1
26	nitric oxide32 9 18 9	11.4	EPX, APOH, MPO, TIMP1, NOS2, NOD2
27	herbimycin a32 42	9.2	MMP1, TIMP1, NOS2, MMP9, CD40LG
28	epinephrine32 9 18 9	11.2	MMP9, MMP1, CD79A, TG, RNASE3
29	vitamin b1232	8.1	CD40LG, TIMP1, LTF, APOH, CD79A, MPO
30	acetylcholine32 9 18 9	11.1	CD40LG, CD79A, MPO, RNASE3, TG, NOS2
31	adenylate32	8.0	CD40LG, TIMP1, LTF, RNASE3, NOS2, MMP9
32	histamine32 18	8.9	EPX, LTF, RNASE3, CD40LG, CD79A, MPO
33	fibrinogen32	7.8	LTF, RNASE3, CTGF, CD79A, MMP9, CD40LG
34	aspirin32 34 18	9.8	CD40LG, MMP1, APOH, RNASE3, TIMP1, CD79A
35	prednisolone32 9 9	9.6	EPX, TG, RNASE3, NOD2, APOH, MMP1
36	doxycycline32 9 9	9.6	TIMP1, LTF, CD79A, MMP9, MMP1, CD40LG
37	formaldehyde32 18	8.6	MMP1, CD40LG, EPX, MMP9, RNASE3, CD79A
38	indomethacin32 9 9	9.6	TIMP1, LTF, NOS2, MMP1, MPO, CD79A
39	norepinephrine32 9 18 9	10.2	CD40LG, TG, TIMP1, LTF, MMP9, MMP1
40	cysteine32	7.0	EPX, CTGF, TIMP1, CD79A, LTF, MMP1
41	paraffin32	6.9	CD79A, CD40LG, MMP1, LTF, TIMP1, TG
42	serine32	6.8	NOD2, CTGF, TIMP1, LTF, TG, MMP9
43	cyclosporin a32 42	7.7	CD79A, CD40LG, MMP1, MMP9, RNASE3, LTF
44	dexamethasone32 42 34 9 9	10.6	MMP1, RNASE3, NOS2, EPX, TIMP1, LTF
45	n acetylcysteine32	6.6	CD40LG, RNASE3, MPO, CD79A, TIMP1, LTF
46	retinoic acid32 42 18	8.4	MMP1, LTF, TIMP1, TG, CTGF, MMP9
47	creatinine32	6.3	LTF, MPO, CD79A, MMP1, EPX, APOH
48	lactate32	6.2	MPO, CD79A, APOH, CTGF, RNASE3, TG
49	estrogen32	6.1	CD79A, TG, MMP1, APOH, CTGF, NOS2
50	vegf32	5.9	MPO, TIMP1, TG, RNASE3, NOS2, LTF

Cellular components related to collagenous colitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	8.7	COL14A1, CTGF, MMP1, MMP9
2	extracellular space	GO:005615	7.8	CTGF, APOH, MMP9, CD40LG, MPO, COL14A1
3	extracellular region	GO:005576	7.2	MMP1, TG, TIMP1, LTF, RNASE3, COL14A1

Biological processes related to collagenous colitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	defense response to bacterium	GO:042742	9.4	LTF, RNASE3, NOS2, NOD2
2	B cell proliferation	GO:042100	9.1	CD79A, CD40LG
3	extracellular matrix disassembly	GO:022617	8.8	MMP1, TIMP1, MMP9
4	extracellular matrix organization	GO:030198	8.2	COL14A1, MMP9, MMP1, TIMP1

Molecular functions related to collagenous colitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:008201	9.2	MPO, APOH, CTGF, LTF