MCID: CLL021
MIFTS: 50

Collagenous Colitis malady

Rare diseases, Gastrointestinal diseases categories

Aliases & Classifications for Collagenous Colitis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 27ICD9CM, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Collagenous Colitis, Aliases & Descriptions:

Name: Collagenous Colitis 9 41 43 47
Microscopic Colitis, Collagenous Type 41
 
Colitis, Collagenous 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

47
collagenous colitis:
Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Sweden),1-9/1000000 (France),1-9/100000 (United States),1-9/100000 (Spain),1-9/100000 (Iceland),1-9/100000 (Canada); Age of onset: Adult,Elderly; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:0060183
ICD9CM27 558.9
MeSH33 D046729
Orphanet47 36205
MESH via Orphanet34 D046729
ICD10 via Orphanet26 K52.8
UMLS via Orphanet61 C0238067

Summaries for Collagenous Colitis

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NIH Rare Diseases:41 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as microscopic colitis, collagenous type, is related to colitis and inflammatory bowel disease. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Leishmaniasis and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds thiocyanate and budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related mouse phenotypes are skeleton and cardiovascular system.

Disease Ontology:9 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:63 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1colitis32.4MPO, NOD2, NOS2, LTF
2inflammatory bowel disease31.1CD79A, MPO
3diarrhea31.1CHGA, CD79A, LTF
4food allergy30.9RNASE3, EPX
5spondylitis30.9NOD2
6ileitis30.8MPO, NOD2
7lupus erythematosus30.7CD79A, APOH, CD40LG
8polyarteritis nodosa30.7MPO, LTF
9proctitis30.6LTF, EPX, RNASE3
10gastritis30.6CHGA, NOS2, CD79A, LTF
11ulcerative colitis30.5MPO, RNASE3, EPX, MMP1, NOS2, NOD2
12psoriatic arthritis30.5MMP1, NOD2
13arthritis30.3LTF, MMP9, TIMP1, MMP1, NOD2, NOS2
14systemic lupus erythematosus30.2APOH, CD79A, MPO, NOD2, CD40LG, LTF
15hepatitis c30.2LTF, MMP1, TIMP1, CD40LG
16pulmonary fibrosis30.0TIMP1, MMP9, CTGF, MPO, MMP1
17rheumatoid arthritis28.8CD79A, CTGF, LTF, NOD2, SCG2, MMP9
18lymphocytic colitis10.7
19chronic rhinitis10.6RNASE3
20eosinophil peroxidase deficiency10.6EPX
21toxocariasis10.6RNASE3
22cryptosporidiosis10.6CD79A
23mononeuropathy10.6MPO
24urethritis10.5CD79A
25microscopic colitis10.5
26chickenpox10.5CD79A
27retinal vasculitis10.5APOH
28q fever10.5CD79A
29lactose intolerance10.5LTF
30keratoconjunctivitis sicca10.5LTF
31systemic scleroderma10.5CTGF
32endocarditis10.5EPX
33macroglobulinemia10.5CD79A
34blepharitis10.5LTF
35purpura10.5CD79A
36oral candidiasis10.5LTF
37periodontitis10.5MMP9
38onchocerciasis10.5EPX, RNASE3
39blindness10.5
40asthma10.5RNASE3, EPX
41pulmonary eosinophilia10.5RNASE3, EPX
42syphilis10.5APOH, CD79A
43hypersensitivity vasculitis10.4CD79A, MPO
44giant papillary conjunctivitis10.4RNASE3, LTF
45toxoplasmosis10.4CD40LG, CD79A
46myxedema10.4TG
47congenital toxoplasmosis10.4CD79A, CD40LG
48conjunctivitis10.4CD79A, RNASE3
49immunoglobulin g deficiency10.4CD40LG, CD79A
50selective iga deficiency disease10.4CD40LG, CD79A

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Drug clinical trials:

Search ClinicalTrials for Collagenous Colitis

Search NIH Clinical Center for Collagenous Colitis

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

31
Colon, Small intestine, T cells, Endothelial, Liver

Animal Models for Collagenous Colitis or affiliated genes

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MGI Mouse Phenotypes related to Collagenous Colitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CTGF, CD40LG, NOD2, NOS2, COL14A1, MMP9
2MP:00053858.1MPO, TIMP1, MMP9, CHGA, NOS2, CD40LG
3MP:00107687.5APOH, MPO, TIMP1, MMP9, CHGA, NOS2
4MP:00053877.4MMP9, EPX, TIMP1, MPO, MMP1, NOS2
5MP:00053797.4TIMP1, TG, CHGB, CHGA, NOS2, CD40LG
6MP:00053977.3MPO, TIMP1, TG, EPX, MMP9, NOS2
7MP:00053765.4LTF, APOH, MPO, TIMP1, TG, MMP9

Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Collagenous colitis during treatment with fumaric acid esters. (25482705)
2014
2
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. (24526204)
2014
3
Acute onset collagenous colitis with unique endoscopic findings. (25610672)
2014
4
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
5
Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. (23200274)
2013
6
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
7
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010. (22719191)
2012
8
Is smoking a risk factor for collagenous colitis? (21854096)
2011
9
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study. (21557718)
2011
10
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
11
Mucosal scars in collagenous colitis. (20105482)
2010
12
Mucosal tear in collagenous colitis. (18691941)
2009
13
Interventions for treating collagenous colitis. (18425892)
2008
14
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
15
Colonic perforation as a complication of collagenous colitis in a series of 12 patients. (18702648)
2008
16
Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis. (18513560)
2008
17
Collagenous colitis: oral low-dose methotrexate for patients with difficult symptoms: long-term outcomes. (17845686)
2007
18
Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. (17718794)
2007
19
Collagenous colitis in adult Sri Lankans: experience from the Indian subcontinent. (16474114)
2006
20
Long-term follow-up of collagenous colitis after induction of clinical remission with budesonide. (16305725)
2005
21
Interventions for treating collagenous colitis: a Cochrane Inflammatory Bowel Disease Group systematic review of randomized trials. (15571596)
2004
22
Collagenous colitis with spondyloarthropathy presenting as fibromyalgia syndrome. (15229969)
2004
23
Fractured colon: an endoscopically distinctive lesion associated with colonic perforation following colonoscopy in patients with collagenous colitis. (15087693)
2004
24
Further report of familial occurrence of collagenous colitis. (12374242)
2002
25
Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. (11781276)
2002
26
Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis. (11569721)
2001
27
Collagenous colitis in an adult patient with chronic diarrhoea: case report. (12002091)
2001
28
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
29
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
30
Collagenous colitis: a long-term follow-up study. (10755251)
1999
31
Autoantibodies and immunoglobulins in collagenous colitis. (8881813)
1996
32
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
33
Olsalazine in collagenous colitis. (8031693)
1994
34
Collagenous colitis: an unusual endoscopic appearance. (8495846)
1993
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. (1361906)
1992
37
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
38
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990
39
Collagenous colitis. (2407439)
1990
40
Diarrhoea caused by collagenous colitis. (2774620)
1989
41
Collagenous colitis. (3337067)
1988
42
Increased subepithelial collagen deposition is not specific for collagenous colitis. (3237709)
1988
43
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
44
Collagenous colitis: an association with fecal leukocytes. (3230281)
1988
45
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
46
Collagenous colitis: physiologic and histopathologic studies in seven patients. (3789577)
1987
47
Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. (3610134)
1987
48
Collagenous colitis. (6524458)
1984
49
Collagenous colitis. Report of a case. (6697827)
1984
50
Collagenous colitis: the clinical and morphological features. (7122380)
1982

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CD40LG, NOS2, NOD2
29.7MMP1, TIMP1
39.6MMP9, MMP1
4
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.6NOS2, TIMP1, MPO
59.5MPO, MMP9, CTGF
6
Show member pathways
9.2TIMP1, MMP9, MMP1
7
Show member pathways
Metalloproteases in connective tissue degradation
9.2TIMP1, MMP9, MMP1
8
Show member pathways
9.2CD40LG, EPX, RNASE3, TG
9
Show member pathways
8.9MMP9, MMP1, TIMP1, COL14A1
10
Show member pathways
8.7MMP9, CTGF, CD79A, MMP1, TIMP1

Compounds for genes affiliated with Collagenous Colitis

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Compounds related to Collagenous Colitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 238)
idCompoundScoreTop Affiliating Genes
1thiocyanate43 2410.7MPO, LTF, CD79A, EPX
2budesonide43 49 1211.5MPO, RNASE3, LTF, EPX
3gliadin439.4TG, RNASE3, CD40LG, CD79A
4minocycline43 1210.3TIMP1, MMP9, NOS2, LTF
5theophylline43 28 24 1212.2EPX, CD40LG, CD79A, CHGA, RNASE3
6endotoxin439.2NOS2, APOH, CD40LG, LTF, RNASE3, NOD2
7anti-fungal439.1CD40LG, CHGA, CD79A, RNASE3, LTF
8leukotriene b443 59 2411.1EPX, RNASE3, MPO, MMP9, LTF
9vitamin b12439.0MPO, APOH, CD40LG, LTF, TIMP1, CD79A
10ivig439.0MMP9, APOH, CD40LG, TG, CD79A
11procollagen438.9CTGF, COL14A1, MMP9, TIMP1, MMP1
12ribavirin43 49 1210.9TIMP1, MMP9, LTF, MMP1, CD40LG
13aspirin43 49 28 2411.9CD40LG, MMP1, RNASE3, TIMP1, APOH, CD79A
14alpha tocopherol438.7APOH, TIMP1, MMP9, MMP1, CTGF
15doxycycline43 129.7MMP9, CD40LG, CD79A, MMP1, TIMP1, LTF
16indomethacin43 28 59 1211.7LTF, MPO, TIMP1, MMP1, NOS2, CD79A
17p002438.6TIMP1, RNASE3, EPX, CHGA, CTGF, MMP9
18ascorbic acid43 249.5CD79A, MMP1, LTF, MPO, CD40LG, TG
19prednisolone43 28 1210.5MMP1, NOD2, CD79A, TG, MPO, APOH
20vitamin a43 24 1210.3TIMP1, TG, MMP9, MMP1, CD40LG, LTF
21formaldehyde43 249.3MMP9, MMP1, CHGA, CD79A, MPO, RNASE3
22rantes438.3TIMP1, CD40LG, MMP1, MMP9, SCG2, RNASE3
23nitric oxide43 24 1210.3NOD2, TIMP1, CHGA, RNASE3, MPO, EPX
24fibrinogen438.3CD79A, CD40LG, CTGF, APOH, LTF, CHGA
25hyaluronic acid43 249.2MMP9, CD79A, COL14A1, MMP1, RNASE3, TIMP1
26phorbol438.2TIMP1, CHGA, MMP1, MMP9, RNASE3
27epinephrine43 24 1210.2RNASE3, TG, MMP9, CD79A, MMP1, CHGA
28ribonucleic acid438.1TIMP1, CTGF, CHGA, MMP1, MMP9, TG
29acetylcholine43 49 28 24 1211.9NOS2, CHGA, RNASE3, TG, MPO, SCG2
30arginine437.9CD40LG, APOH, TIMP1, TG, CD79A, NOS2
31heparin43 28 24 1210.9CTGF, MPO, TG, RNASE3, CD40LG, EPX
32n acetylcysteine437.9NOS2, CD79A, CD40LG, CTGF, LTF, TIMP1
33h2o2437.8CTGF, TG, CD79A, LTF, MMP1, EPX
34cyclosporin a43 28 599.8MMP1, RNASE3, TG, TIMP1, CD79A, CD40LG
35histamine43 28 249.7EPX, SCG2, CD40LG, CD79A, CHGA, LTF
36cycloheximide437.7MMP9, TG, CTGF, NOS2, CHGA, MMP1
37pge2437.6MMP9, LTF, CTGF, CD40LG, CD79A, NOS2
38glutamate437.5APOH, TIMP1, TG, CHGA, CD79A, LTF
39paraffin437.4LTF, CD40LG, CHGA, MMP1, MMP9, TG
40adenylate437.3LTF, CD40LG, NOS2, CHGA, MMP9, TG
41retinoic acid43 248.0MMP1, TG, RNASE3, CHGA, TIMP1, CD40LG
42creatinine436.9MMP9, EPX, RNASE3, TG, MPO, APOH
43lactate436.9TIMP1, CTGF, MPO, APOH, MMP9, CHGA
44cysteine436.6CD79A, CHGA, CD40LG, CTGF, LTF, MMP1
45calcium43 49 24 129.4MPO, RNASE3, EPX, CHGA, APOH, SCG2
46norepinephrine43 24 128.3CHGB, TG, CHGA, CD79A, CD40LG, LTF
47serine436.2MMP9, CTGF, CD40LG, NOD2, CHGA, CHGB
48estrogen436.0LTF, CTGF, CD79A, NOS2, CHGA, CHGB
49dexamethasone43 49 28 128.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA
50vegf435.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA

GO Terms for genes affiliated with Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.1CTGF, COL14A1, MMP1, MMP9
2secretory granuleGO:00301417.8SCG2, MPO, CHGB, CHGA, LTF
3extracellular spaceGO:00056156.9SCG2, APOH, MPO, TG, MMP9, COL14A1
4extracellular regionGO:00055766.3LTF, TIMP1, TG, RNASE3, MMP9, MMP1

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:004413010.0NOD2, MPO
2positive regulation of interleukin-12 productionGO:00327359.9CD40LG, NOD2
3hydrogen peroxide catabolic processGO:00427449.9MPO, EPX
4innate immune response in mucosaGO:00022279.9LTF, NOD2, NOS2
5defense response to bacteriumGO:00427429.9NOD2, NOS2, RNASE3
6ossificationGO:00015039.6MMP9, CTGF, LTF
7collagen catabolic processGO:00305749.5COL14A1, MMP1, MMP9
8extracellular matrix disassemblyGO:00226179.1COL14A1, MMP1, MMP9, TIMP1
9extracellular matrix organizationGO:00301989.0TIMP1, MMP9, MMP1, COL14A1
10negative regulation of apoptotic processGO:00430668.9LTF, CD40LG, TIMP1, MPO

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peroxidase activityGO:000460110.0EPX, MPO
2heme bindingGO:00200379.5NOS2, EPX, MPO
3heparin bindingGO:00082019.3LTF, CTGF, MPO, APOH

Products for genes affiliated with Collagenous Colitis

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Sources for Collagenous Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet