MCID: CLL021
MIFTS: 38

Collagenous Colitis malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Collagenous Colitis:

Name: Collagenous Colitis 10 45 47 12 51
Colitis, Collagenous 36 65
 
Microscopic Colitis, Collagenous Type 45

Characteristics:

Orphanet epidemiological data:

51
collagenous colitis:
Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Sweden),1-9/1000000 (France),1-9/100000 (United States),1-9/100000 (Spain),1-9/100000 (Iceland),1-9/100000 (Canada); Age of onset: Adult,Elderly; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology10 DOID:0060183
ICD1027 K52.89
MeSH36 D046729
NCIt42 C27021
SNOMED-CT59 19311003
Orphanet51 36205
ICD10 via Orphanet28 K52.8
MESH via Orphanet37 D046729
UMLS via Orphanet66 C0238067
UMLS65 C0238067

Summaries for Collagenous Colitis

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NIH Rare Diseases:45 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as colitis, collagenous, is related to villonodular synovitis and lymphocytic colitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways are FSH signaling pathway and TSH signaling pathway. Affiliated tissues include colon, liver and testes, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:10 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:68 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1villonodular synovitis29.9CD79A, MPO
2lymphocytic colitis27.7CD79A, CHGA, CHGB, COL14A1, LTF, MPO
3microscopic colitis10.4
4collagenous gastritis10.4
5timothy grass allergy10.3MPO, RNASE3
6chronic sphenoidal sinusitis10.3MPO, RNASE3
7balkan nephropathy10.3MPO, RNASE3
8anterior dislocation of lens10.3LTF, RNASE3
9papillary conjunctivitis10.3LTF, RNASE3
10cystitis10.2CD79A, RNASE3
11egg allergy10.2CD79A, RNASE3
12choroid plexus meningioma10.2CD79A, MPO
13generalized atherosclerosis10.2CD79A, MPO
14breast cancer10.2
15leukemia10.2
16neuronitis10.2
17exudative glomerulonephritis10.2CD79A, MPO
18angioedema10.2CD79A, MPO
19diffuse secondary choroid atrophy10.2CD79A, MPO
20crescentic glomerulonephritis10.2CD79A, MPO
21hypersensitivity vasculitis10.2CD79A, MPO
22hemosiderosis10.2CD79A, MPO
23goat milk allergy10.2CD79A, RNASE3
24bronchial neoplasm10.2CD79A, MPO
25focal embolic glomerulonephritis10.2CD79A, MPO
26cervical incompetence10.2CD79A, MPO
27melorheostosis10.2CD79A, RNASE3
28colorectal cancer10.2
29endotheliitis10.2
30enamel caries10.1CD79A, RNASE3
31legionellosis10.1CD79A, NOS2
32acalculous cholecystitis10.1CD79A, RNASE3
33trachoma10.1CD79A, NOS2
34meckel's diverticulum10.1CD79A, LTF
35postcholecystectomy syndrome10.1CD79A, RNASE3
36lung cancer10.1
37esophagitis10.1
38adenocarcinoma10.1
39retinitis10.1
40pneumonia10.1
41intestinal botulism10.1CD79A, LTF
42hodgkin's lymphoma, nodular sclerosis10.1CD79A, RNASE3
43paralytic squint10.1CD79A, LTF
44shigellosis10.1CD79A, LTF
45anus disease10.0LTF, MPO, RNASE3
46chronic conjunctivitis10.0CD79A, LTF
47prostate cancer10.0
48adrenoleukodystrophy10.0
49hepatitis10.0
50paroxysmal nocturnal hemoglobinuria10.0

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BudesonideapprovedPhase 338151333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide Inhalation
Budesonide MMX
Budesonide Nasal
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
 
Horacort
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort FLEXHALER
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Uceris
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
2Anti-Asthmatic AgentsPhase 32796
3Respiratory System AgentsPhase 33931
4Analgesics, Non-NarcoticPhase 35184
5Anti-Inflammatory Agents, Non-SteroidalPhase 33549
6Antirheumatic AgentsPhase 38496
7Peripheral Nervous System AgentsPhase 318510
8MesalaminePhase 315289-57-6
9AnalgesicsPhase 39358
10Bronchodilator AgentsPhase 32377
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 39988
12glucocorticoidsPhase 33896
13Anti-Inflammatory AgentsPhase 38478
14HormonesPhase 311748
15Hormone AntagonistsPhase 310002
16Pharmaceutical Solutions7004
17Gastrointestinal Agents6401
18
Bismuth1037440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
19Anti-Ulcer Agents1453
20Antacids1453
21ColaNutraceutical1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Budesonide for Maintenance Treatment of Collagenous ColitisCompletedNCT00180076Phase 3
2SOIBD Collagenous Colitis Maintenance StudyCompletedNCT01278082Phase 3
3Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous ColitisCompletedNCT00450086Phase 3
4Long-Term Treatment of Collagenous Colitis With BudesonideActive, not recruitingNCT00139165Phase 3
5Usefulness of Chromoendoscopy in Diagnosing Microscopic ColitisRecruitingNCT01504048
6Case-Control Study to Identify Risk Factors for Microscopic ColitisEnrolling by invitationNCT01928667
7Treatment of Microscopic ColitisTerminatedNCT00184171

Search NIH Clinical Center for Collagenous Colitis


Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

33
Colon, Liver, Testes, Prostate, B cells, Lung, Monocytes

Animal Models for Collagenous Colitis or affiliated genes

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MGI Mouse Phenotypes related to Collagenous Colitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1CD79A, CHGA, CHGB, COL14A1, LTF, MPO

Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50)    (show all 419)
idTitleAuthorsYear
1
Safety and efficacy of denosumab in children with osteogenesis imperfecta - a first prospective trial. (26944820)
2016
2
NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway. (25692647)
2015
3
Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. (26516010)
2015
4
Agricultural work exposures and pulmonary function among hired farm workers in California (the MICASA study). (25275408)
2014
5
Cyprodinil as an activator of aryl hydrocarbon receptor. (23228475)
2013
6
Prevalence of the HOXB13 G84E Mutation Among Unaffected Men with a Family History of Prostate Cancer. (24310616)
2013
7
Deep transcranial magnetic stimulation for the treatment of pathological gambling. (23078873)
2013
8
Mid-gestational gene expression profile in placenta and link to pregnancy complications. (23145134)
2012
9
Surgical management for upper urinary tract transitional cell carcinoma (UUT-TCC): a systematic review. (22759317)
2012
10
Natural history of tako-tsubo cardiomyopathy. (20884730)
2011
11
Primary intramedullary spinal cord lymphoma. (21832220)
2011
12
Prevalence, phenomenology, aetiology and predictors of challenging behaviour in Smith-Magenis syndrome. (21199049)
2011
13
Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. (20007677)
2010
14
Autoimmune polyglandular syndrome type 2: an unusual presentation. (21137658)
2010
15
Adipose tissue lamin A/C messenger RNA expression in women. (20045150)
2010
16
Dorzolamide use in the management of macular cysts in a patient with enhanced s-cone syndrome. (25391052)
2009
17
Survivin and COX-2 expression in male breast carcinoma. (19632843)
2009
18
Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. (18057099)
2008
19
Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. (19668496)
2007
20
Ten novel RB1 gene mutations in patients with retinoblastoma. (17960112)
2007
21
Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia. (16418492)
2006
22
Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)
2005
23
Distribution of selenium-containing proteins in human serum. (15326360)
2004
24
Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. (15342342)
2004
25
Disease-causing mutations in the cellular retinaldehyde binding protein tighten and abolish ligand interactions. (12536144)
2003
26
Expression of circadian rhythm genes in gonadotropin-releasing hormone-secreting GT1-7 neurons. (12960008)
2003
27
Physiological or pathological--a role for relaxin in the cardiovascular system? (12681237)
2003
28
Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. (11744603)
2002
29
Explosive growth of uterine leiomyomas and carcinologic ovarian risk in a non-menopausal patient with BRCA1-BRCA2 mutation treated by tamoxifen]. (12457141)
2002
30
Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. (10993727)
2000
31
NMR structure of a concatemer of the first and second ligand-binding modules of the human low-density lipoprotein receptor. (10933493)
2000
32
Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling. (10950967)
2000
33
Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules. (10515863)
1999
34
Probing the rRNA environment of ribosomal protein S5 across the subunit interface and inside the 30 S subunit using tethered Fe(II). (9973556)
1999
35
Connexin 50 mutation in a family with congenital 'zonular nuclear' pulverulent cataract of Pakistani origin. (10480374)
1999
36
The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two-dimensional gel electrophoresis. (9687549)
1998
37
Severe bleeding tendency in a patient with Bernard-Soulier syndrome associated with a homozygous single base pair deletion in the gene coding for the human platelet glycoprotein Ibalpha. (9628437)
1998
38
Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction. (9446564)
1998
39
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite. (9349538)
1997
40
Effect of Gluma desensitization on dentin bond strength. (7576381)
1995
41
Protein tyrosine phosphorylation in human platelets during shear stress-induced platelet aggregation (SIPA) is regulated by glycoprotein (GP) Ib/IX as well as GP IIb/IIIa and requires intact cytoskeleton and endogenous ADP. (8585015)
1995
42
Surfactant proteins A (SP-A) and D (SP-D): levels in human amniotic fluid and localization in the fetal membranes. (8305484)
1994
43
Sexual acquisition of acute pyelonephritis in a man. (8460339)
1993
44
Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts. (8408644)
1993
45
Treatment of uterine fibroids: current findings with gonadotropin-releasing hormone agonists. (1531577)
1992
46
In-vitro stimulation of TNF-alpha from human whole blood by cell-free supernatants of gram-positive bacteria. (1421002)
1992
47
Rural/urban differences of diabetes--impaired glucose tolerance, hypertension, obesity, glycosolated haemoglobin, nutritional proteins, fasting cholesterol and apolipoproteins in Fijian Melanesians over 40. (2109332)
1990
48
Brittle diabetes and stroke: a complicated rehabilitation problem. (7016066)
1981
49
Malabsorption of folate polyglutamates in tropical sprue. (5769888)
1969
50
Kernicterus. (14819084)
1951

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3CHGA, RNASE3
29.3CHGA, RNASE3
3
Show member pathways
9.0CHGA, NOS2, RNASE3

GO Terms for genes affiliated with Collagenous Colitis

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Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell redox homeostasisGO:00454549.6LTF, NOS2
2defense response to Gram-positive bacteriumGO:00508309.5CHGA, RNASE3
3innate immune response in mucosaGO:00022279.3LTF, NOS2
4defense response to Gram-negative bacteriumGO:00508299.2CHGA, NOS2

Sources for Collagenous Colitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet