MCID: CLL021
MIFTS: 56

Collagenous Colitis malady

Rare diseases, Gastrointestinal diseases categories

Summaries for Collagenous Colitis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards: Collagenous Colitis, also known as microscopic colitis, collagenous type, is related to diarrhea and ulcerative colitis. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Leishmaniasis and Immune response Oncostatin M signaling via JAK Stat in human cells. The compounds thiocyanate and budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and endothelial, and related mouse phenotypes are skeleton and cardiovascular system.

Wikipedia:66 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Aliases & Classifications for Collagenous Colitis

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
collagenous colitis:
Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

collagenous colitis 44 46 50
microscopic colitis, collagenous type 44
colitis, collagenous 63


External Ids:

ICD10 via Orphanet27 K52.8
SNOMED-CT via Orphanet60 19311003
UMLS via Orphanet64 C0238067
MESH via Orphanet37 D046729

Related Diseases for Collagenous Colitis

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18GeneCards, 19GeneDecks
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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.8CHGA, CD79A, LTF
2ulcerative colitis30.8MPO, RNASE3, EPX, MMP1, NOS2, NOD2
3arthritis30.7LTF, MMP9, TIMP1, MMP1, NOD2, NOS2
4crohn's disease30.7MPO, NOD2
5inflammatory bowel disease30.6CD79A, MPO
6gastritis30.4CHGA, NOS2, CD79A, LTF
7food allergy30.4RNASE3, EPX
8lupus erythematosus30.4CD79A, APOH, CD40LG
9psoriatic arthritis30.3MMP1, NOD2
10systemic lupus erythematosus30.3APOH, CD79A, MPO, NOD2, CD40LG, LTF
11spondylitis30.2NOD2
12polyarteritis nodosa30.2MPO, LTF
13proctitis30.2LTF, EPX, RNASE3
14ankylosing spondylitis30.2CD40LG, CD79A, NOD2
15rheumatoid arthritis30.1CD79A, CTGF, LTF, NOD2, SCG2, MMP9
16hepatitis c30.1LTF, MMP1, TIMP1, CD40LG
17pulmonary fibrosis30.0TIMP1, MMP9, CTGF, MPO, MMP1
18lymphocytic colitis10.7
19microscopic colitis10.5
20blindness10.5
21pyoderma gangrenosum10.3
22pyoderma10.3
23protein-losing enteropathy10.3
24celiac disease10.3
25collagenous gastritis10.3
26toxic megacolon10.2
27common variable immunodeficiency10.2
28amyloidosis10.2
29constipation10.2
30hyperparathyroidism10.2
31megacolon10.2
32spondyloarthropathy10.2
33spondylarthropathy10.2
34endotheliitis10.2
35chronic rhinitis10.1RNASE3
36eosinophil peroxidase deficiency10.1EPX
37toxocariasis10.1RNASE3
38cryptosporidiosis10.1CD79A
39mononeuropathy10.1MPO
40urethritis10.1CD79A
41chickenpox10.1CD79A
42retinal vasculitis10.1APOH
43q fever10.1CD79A
44lactose intolerance10.1LTF
45systemic scleroderma10.1CTGF
46endocarditis10.1EPX
47keratoconjunctivitis sicca10.1LTF
48macroglobulinemia10.1CD79A
49blepharitis10.1LTF
50purpura10.1CD79A

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Collagenous Colitis

Drug clinical trials:

Search ClinicalTrials for Collagenous Colitis

Search NIH Clinical Center for Collagenous Colitis

Search CenterWatch for Collagenous Colitis

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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34MalaCards
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MalaCards organs/tissues related to Collagenous Colitis:

34
Colon, Small intestine, Endothelial, Liver, T cells

Animal Models for Collagenous Colitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Collagenous Colitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CTGF, CD40LG, NOD2, NOS2, COL14A1, MMP9
2MP:00053858.1MPO, TIMP1, MMP9, CHGA, NOS2, CD40LG
3MP:00107687.5APOH, MPO, TIMP1, MMP9, CHGA, NOS2
4MP:00053877.4MMP9, EPX, TIMP1, MPO, MMP1, NOS2
5MP:00053797.4TIMP1, TG, CHGB, CHGA, NOS2, CD40LG
6MP:00053977.3MPO, TIMP1, TG, EPX, MMP9, NOS2
7MP:00053765.4LTF, APOH, MPO, TIMP1, TG, MMP9

Publications for Collagenous Colitis

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53PubMed
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Articles related to Collagenous Colitis:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
2
Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. (23200274)
2013
3
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
4
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010. (22719191)
2012
5
Is smoking a risk factor for collagenous colitis? (21854096)
2011
6
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study. (21557718)
2011
7
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
8
Mucosal scars in collagenous colitis. (20105482)
2010
9
Mucosal tear in collagenous colitis. (18691941)
2009
10
Interventions for treating collagenous colitis. (18425892)
2008
11
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
12
Colonic perforation as a complication of collagenous colitis in a series of 12 patients. (18702648)
2008
13
Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis. (18513560)
2008
14
Collagenous colitis: oral low-dose methotrexate for patients with difficult symptoms: long-term outcomes. (17845686)
2007
15
Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. (17718794)
2007
16
Collagenous colitis in adult Sri Lankans: experience from the Indian subcontinent. (16474114)
2006
17
Colonic mucosal tears in collagenous colitis. (16716973)
2006
18
Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis. (16373277)
2006
19
Long-term follow-up of collagenous colitis after induction of clinical remission with budesonide. (16305725)
2005
20
Interventions for treating collagenous colitis: a Cochrane Inflammatory Bowel Disease Group systematic review of randomized trials. (15571596)
2004
21
Collagenous colitis with spondyloarthropathy presenting as fibromyalgia syndrome. (15229969)
2004
22
Fractured colon: an endoscopically distinctive lesion associated with colonic perforation following colonoscopy in patients with collagenous colitis. (15087693)
2004
23
Further report of familial occurrence of collagenous colitis. (12374242)
2002
24
Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. (11781276)
2002
25
Interventions for treating collagenous colitis. (12519604)
2002
26
Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis. (11569721)
2001
27
Collagenous colitis in an adult patient with chronic diarrhoea: case report. (12002091)
2001
28
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
29
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
30
Collagenous colitis: a long-term follow-up study. (10755251)
1999
31
Autoantibodies and immunoglobulins in collagenous colitis. (8881813)
1996
32
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
33
Olsalazine in collagenous colitis. (8031693)
1994
34
Collagenous colitis: an unusual endoscopic appearance. (8495846)
1993
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. (1361906)
1992
37
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
38
Metachronous occurrence of collagenous colitis and ulcerative colitis. (2026344)
1991
39
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990
40
Diarrhoea caused by collagenous colitis. (2774620)
1989
41
Collagenous colitis. (3337067)
1988
42
Increased subepithelial collagen deposition is not specific for collagenous colitis. (3237709)
1988
43
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
44
Collagenous colitis: an association with fecal leukocytes. (3230281)
1988
45
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
46
Collagenous colitis: physiologic and histopathologic studies in seven patients. (3789577)
1987
47
Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. (3610134)
1987
48
Collagenous colitis. (6524458)
1984
49
Collagenous colitis. Report of a case. (6697827)
1984
50
Collagenous colitis: the clinical and morphological features. (7122380)
1982

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 13EMD Millipore
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Pathways related to Collagenous Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CD40LG, NOS2, NOD2
29.7MMP1, TIMP1
39.6MMP9, MMP1
4
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.6NOS2, TIMP1, MPO
59.5MPO, MMP9, CTGF
6
Show member pathways
9.2TIMP1, MMP9, MMP1
7
Show member pathways
9.2TIMP1, MMP9, MMP1
8
Show member pathways
9.2CD40LG, EPX, RNASE3, TG
9
Show member pathways
8.9MMP9, MMP1, TIMP1, COL14A1
10
Show member pathways
8.7MMP9, CTGF, CD79A, MMP1, TIMP1

Compounds for genes affiliated with Collagenous Colitis

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46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Collagenous Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 238)
idCompoundScoreTop Affiliating Genes
1thiocyanate46 2510.7MPO, LTF, CD79A, EPX
2budesonide46 52 1211.5MPO, RNASE3, LTF, EPX
3gliadin469.4TG, RNASE3, CD40LG, CD79A
4minocycline46 1210.3TIMP1, MMP9, NOS2, LTF
5theophylline46 30 25 1212.2EPX, CD40LG, CD79A, CHGA, RNASE3
6endotoxin469.2NOS2, APOH, CD40LG, LTF, RNASE3, NOD2
7anti-fungal469.1CD40LG, CHGA, CD79A, RNASE3, LTF
8leukotriene b446 62 2511.1EPX, RNASE3, MPO, MMP9, LTF
9vitamin b12469.0MPO, APOH, CD40LG, LTF, TIMP1, CD79A
10ivig469.0MMP9, APOH, CD40LG, TG, CD79A
11procollagen468.9CTGF, COL14A1, MMP9, TIMP1, MMP1
12ribavirin46 52 1210.9TIMP1, MMP9, LTF, MMP1, CD40LG
13aspirin46 52 30 2511.9CD40LG, MMP1, RNASE3, TIMP1, APOH, CD79A
14alpha tocopherol468.7APOH, TIMP1, MMP9, MMP1, CTGF
15doxycycline46 129.7MMP9, CD40LG, CD79A, MMP1, TIMP1, LTF
16indomethacin46 30 62 1211.7LTF, MPO, TIMP1, MMP1, NOS2, CD79A
17p002468.6TIMP1, RNASE3, EPX, CHGA, CTGF, MMP9
18ascorbic acid46 259.5CD79A, MMP1, LTF, MPO, CD40LG, TG
19prednisolone46 30 1210.5MMP1, NOD2, CD79A, TG, MPO, APOH
20vitamin a46 25 1210.3TIMP1, TG, MMP9, MMP1, CD40LG, LTF
21formaldehyde46 259.3MMP9, MMP1, CHGA, CD79A, MPO, RNASE3
22rantes468.3TIMP1, CD40LG, MMP1, MMP9, SCG2, RNASE3
23nitric oxide46 25 1210.3NOD2, TIMP1, CHGA, RNASE3, MPO, EPX
24fibrinogen468.3CD79A, CD40LG, CTGF, APOH, LTF, CHGA
25hyaluronic acid46 259.2MMP9, CD79A, COL14A1, MMP1, RNASE3, TIMP1
26phorbol468.2TIMP1, CHGA, MMP1, MMP9, RNASE3
27epinephrine46 25 1210.2RNASE3, TG, MMP9, CD79A, MMP1, CHGA
28ribonucleic acid468.1TIMP1, CTGF, CHGA, MMP1, MMP9, TG
29acetylcholine46 52 30 25 1211.9NOS2, CHGA, RNASE3, TG, MPO, SCG2
30arginine467.9CD40LG, APOH, TIMP1, TG, CD79A, NOS2
31heparin46 30 25 1210.9CTGF, MPO, TG, RNASE3, CD40LG, EPX
32n acetylcysteine467.9NOS2, CD79A, CD40LG, CTGF, LTF, TIMP1
33h2o2467.8CTGF, TG, CD79A, LTF, MMP1, EPX
34cyclosporin a46 30 629.8MMP1, RNASE3, TG, TIMP1, CD79A, CD40LG
35histamine46 30 259.7EPX, SCG2, CD40LG, CD79A, CHGA, LTF
36cycloheximide467.7MMP9, TG, CTGF, NOS2, CHGA, MMP1
37pge2467.6MMP9, LTF, CTGF, CD40LG, CD79A, NOS2
38glutamate467.5APOH, TIMP1, TG, CHGA, CD79A, LTF
39paraffin467.4LTF, CD40LG, CHGA, MMP1, MMP9, TG
40adenylate467.3LTF, CD40LG, NOS2, CHGA, MMP9, TG
41retinoic acid46 258.0MMP1, TG, RNASE3, CHGA, TIMP1, CD40LG
42creatinine466.9MMP9, EPX, RNASE3, TG, MPO, APOH
43lactate466.9TIMP1, CTGF, MPO, APOH, MMP9, CHGA
44cysteine466.6CD79A, CHGA, CD40LG, CTGF, LTF, MMP1
45calcium46 52 25 129.4MPO, RNASE3, EPX, CHGA, APOH, SCG2
46norepinephrine46 25 128.3CHGB, TG, CHGA, CD79A, CD40LG, LTF
47serine466.2MMP9, CTGF, CD40LG, NOD2, CHGA, CHGB
48estrogen466.0LTF, CTGF, CD79A, NOS2, CHGA, CHGB
49dexamethasone46 52 30 128.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA
50vegf465.9LTF, CTGF, CD40LG, CD79A, NOS2, CHGA

GO Terms for genes affiliated with Collagenous Colitis

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17Gene Ontology
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Cellular components related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.1CTGF, COL14A1, MMP1, MMP9
2secretory granuleGO:0301417.8SCG2, MPO, CHGB, CHGA, LTF
3extracellular spaceGO:0056156.9SCG2, APOH, MPO, TG, MMP9, COL14A1
4extracellular regionGO:0055766.3LTF, TIMP1, TG, RNASE3, MMP9, MMP1

Biological processes related to Collagenous Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.0NOD2, MPO
2positive regulation of interleukin-12 productionGO:0327359.9CD40LG, NOD2
3hydrogen peroxide catabolic processGO:0427449.9MPO, EPX
4innate immune response in mucosaGO:0022279.9LTF, NOD2, NOS2
5defense response to bacteriumGO:0427429.9NOD2, NOS2, RNASE3
6ossificationGO:0015039.6MMP9, CTGF, LTF
7collagen catabolic processGO:0305749.5COL14A1, MMP1, MMP9
8extracellular matrix disassemblyGO:0226179.1COL14A1, MMP1, MMP9, TIMP1
9extracellular matrix organizationGO:0301989.0TIMP1, MMP9, MMP1, COL14A1
10negative regulation of apoptotic processGO:0430668.9LTF, CD40LG, TIMP1, MPO

Molecular functions related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxidase activityGO:00460110.0EPX, MPO
2heme bindingGO:0200379.5NOS2, EPX, MPO
3heparin bindingGO:0082019.3LTF, CTGF, MPO, APOH

Products for genes affiliated with Collagenous Colitis

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Sources for Collagenous Colitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet