MCID: CLL021
MIFTS: 48

Collagenous Colitis malady

Gastrointestinal category

Summaries for Collagenous Colitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards: Collagenous Colitis, also known as microscopic colitis, collagenous type, is related to ulcerative colitis and arthritis. An important gene associated with Collagenous Colitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Syndecan-1-mediated signaling events and amb2 Integrin signaling. The compounds indomethacin and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:64 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Aliases & Classifications for Collagenous Colitis

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
collagenous colitis:
Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

collagenous colitis 43 45 49
microscopic colitis, collagenous type 43
colitis, collagenous 61


External Ids:

ICD10 via Orphanet26 K52.8
SNOMED-CT via Orphanet58 19311003
UMLS via Orphanet62 C0238067
MESH via Orphanet36 D046729

Related Diseases for Collagenous Colitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 237)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis30.8LTF, RNASE3, CD79A, NOD2, NOS2, MPO
2arthritis30.8MMP9, NOD2, MPO, MMP1, CTGF, TIMP1
3pyoderma gangrenosum30.5NOD2
4celiac disease30.4CD79A, TG
5amyloidosis30.2CD79A
6systemic lupus erythematosus30.2MPO, LTF, CD79A, NOD2, APOH, CD40LG
7spondylitis30.0NOD2
8irritable bowel syndrome30.0LTF
9crohn's disease30.0MPO, NOD2
10polyarteritis nodosa30.0MPO, LTF
11proctitis30.0RNASE3, EPX, LTF
12ankylosing spondylitis30.0NOD2, CD79A, CD40LG
13hepatitis c30.0LTF, TIMP1, CD40LG, MMP1
14lymphocytic colitis10.8
15microscopic colitis10.7
16collagenous gastritis10.3
17protein-losing enteropathy10.3
18clostridium difficile10.3
19toxic megacolon10.2
20common variable immunodeficiency10.2
21psoriatic arthritis10.2
22spondyloarthropathy10.2
23micro syndrome10.2
24spondylarthropathy10.2
25secretory diarrhea10.0
26sapho syndrome10.0
27eosinophilic gastritis10.0
28whipple disease10.0
29hepatitis d10.0
30gastroduodenitis10.0
31duodenitis10.0
32osteogenesis imperfecta10.0
33cutaneous polyarteritis nodosa10.0
34retroperitoneal fibrosis10.0
35juvenile scleroderma10.0
36prurigo nodularis10.0
37fibromyalgia10.0
38bronchiolitis10.0RNASE3
39keratoconjunctivitis10.0RNASE3
40myocarditis10.0NOS2
41hypercholesterolemia10.0NOS2
42urticaria10.0RNASE3
43chronic rhinitis10.0RNASE3
44sarcoidosis10.0NOD2
45uveitis10.0NOD2
46acute pancreatitis10.0MPO
47malignant mesothelioma10.0RNASE3
48gastrointestinal system disease10.0NOS2
49encephalomyelitis10.0NOS2
50primary hyperoxaluria10.0CTGF

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Clinical Features for Collagenous Colitis

Drugs & Therapeutics for Collagenous Colitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Collagenous Colitis

Drug clinical trials:

Search ClinicalTrials for Collagenous Colitis

Search NIH Clinical Center for Collagenous Colitis

Search CenterWatch for Collagenous Colitis

Genetic Tests for Collagenous Colitis

Anatomical Context for Collagenous Colitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Collagenous Colitis:

33
Small intestine, Colon, Liver, T cells, B cells, Endothelial

Animal Models for Collagenous Colitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Collagenous Colitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5APOH, CTGF, LTF, CD40LG, CD79A, NOD2
2MP:00053876.8MPO, LTF, CD40LG, CD79A, EPX, MMP9
3MP:00053976.2TG, TIMP1, MPO, LTF, CD40LG, CD79A

Publications for Collagenous Colitis

Sources:
51PubMed
See all sources

Articles related to Collagenous Colitis:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
2
Stable incidence of collagenous colitis and lymphocytic colitis in A9rebro, Sweden, 1999-2008: a continuous epidemiologic study. (23945183)
2013
3
Clinical course of drug-induced collagenous colitis and histological changes after drug withdrawal in a Japanese case series. (22617362)
2012
4
Familial collagenous colitis involving a 6-year old child. (22398039)
2012
5
Is smoking a risk factor for collagenous colitis? (21854096)
2011
6
Mucosal atrophy in collagenous colitis: a case report. (22026584)
2011
7
Low levels of bile acids increase bacterial uptake in colonic biopsies from patients with collagenous colitis in remission. (21366635)
2011
8
Budesonide treatment of patients with collagenous colitis restores normal eosinophil and T-cell activity in the colon. (20027654)
2010
9
Crohn's colitis with perianal disease complicated by collagenous colitis: discourse on management options. (20090331)
2010
10
Linear mucosal defects: a characteristic endoscopic finding of lansoprazole-associated collagenous colitis. (20066608)
2010
11
A colorectal mosaic pattern might be an endoscopic feature of collagenous colitis. (21122497)
2010
12
Lansoprazole-associated collagenous colitis: diffuse mucosal cloudiness mimicking ulcerative colitis. (19418592)
2009
13
Long-term budesonide treatment of collagenous colitis: a randomised, double-blind, placebo-controlled trial. (18669576)
2009
14
Increased transmucosal uptake of E. coli K12 in collagenous colitis persists after budesonide treatment. (19209166)
2009
15
Collagenous colitis in a patient with common variable immunodeficiency. (19123443)
2008
16
Collagenous colitis in a patient with systemic sclerosis: a rare entity. (17595940)
2007
17
Collagenous colitis: possible link with isotretinoin. (16805418)
2006
18
Mucosal tears can occur spontaneously in collagenous colitis. (16767605)
2006
19
In vivo diagnosis of collagenous colitis by confocal endomicroscopy. (16531549)
2006
20
Lymphoproliferative disorders in collagenous colitis. (16043997)
2005
21
Time to remission with budesonide in collagenous colitis. (15948819)
2005
22
Interventions for treating collagenous colitis. (12535479)
2003
23
Endosocopic abnormalities in a Japanese patient with collagenous colitis. (14505141)
2003
24
Collagenous colitis evolving into ulcerative colitis: a case report and review of the literature. (14714620)
2003
25
Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease. (12063968)
2002
26
The subepithelial band in collagenous colitis is autofluorescent a study in H&E stained sections. (12073771)
2002
27
Collagenous colitis in an adult patient with chronic diarrhoea: case report. (12002091)
2001
28
Long-term course in collagenous colitis and the impact of bile acid malabsorption and bile acid sequestrants on histopathology and clinical features. (11424318)
2001
29
Nonsteroidal anti-inflammatory drug-associated colitis with a histology of collagenous colitis. (11473337)
2001
30
Role of bile acids and bile acid binding agents in patients with collagenous colitis. (10644309)
2000
31
Collagenous colitis: a practically orientated approach to diagnosis. (10562895)
1999
32
Tenascin labelling in colorectal biopsies: a useful marker in the diagnosis of collagenous colitis. (10231417)
1999
33
Distribution of morphological changes in collagenous colitis (10464343)
1999
34
Evidence for mast cell activation in collagenous colitis. (9561419)
1998
35
Amyloid colitis mimicking collagenous colitis. (9279575)
1997
36
Lymphocytic and collagenous colitis: an immunohistochemical study. (8677934)
1996
37
Microscopic colitis progressed to collagenous colitis: a morphometric study. (8789825)
1996
38
Collagenous colitis and Crohn's disease: unrelated? (8937945)
1996
39
Interchange between collagenous and lymphocytic colitis in severe disease with autoimmune associations requiring colectomy: a case report. (8707130)
1996
40
Serum Procollagen III Propeptide Is Not of Diagnostic Predictive Value in Collagenous Colitis. (23282426)
1995
41
Cooccurrence of collagenous colitis with seronegative spondyloarthropathy: report of a case and literature review. (8014948)
1993
42
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
43
Lymphocytic (microscopic) colitis. Clinicopathologic study of 18 patients and comparison to collagenous colitis. (2582986)
1989
44
Collagenous colitis in a child. (2773893)
1989
45
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
46
Simultaneous occurrence of collagenous colitis and Crohn's disease. (3556805)
1987
47
Collagenous colitis and rheumatoid arthritis with response to sulfasalazine. A case report and review of the literature. (2888802)
1987
48
Collagenous colitis. (3758824)
1986
49
Collagenous colitis: possible response to sulfasalazine and local steroid therapy. (2857147)
1985
50
Collagenous colitis. (7095378)
1982

Genetic Variations for Collagenous Colitis

Expression for genes affiliated with Collagenous Colitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 54Reactome
See all sources

Compounds for genes affiliated with Collagenous Colitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Collagenous Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 190)
idCompoundScoreTop Affiliating Genes
1indomethacin45 60 29 1113.5LTF
2cardiolipin45 1111.2TG
3norepinephrine45 11 2412.1MMP1, LTF
4alpha tocopherol4510.1CTGF, APOH
5glutamate4510.0APOH, CD40LG
6endotoxin459.9RNASE3, LTF, APOH
7pge2459.8EPX, MMP9
8uva 1459.8MMP1, TIMP1
9acetylcholine45 50 29 11 2413.7NOS2, CD40LG, MPO
10budesonide45 50 1111.6RNASE3, EPX, LTF, MPO
11thiocyanate45 2410.4EPX, LTF, MPO, CD79A
12gliadin459.4CD40LG, CD79A, TG
13hypothiocyanite45 2410.3CD79A, LTF, MPO
14doxycycline45 1110.2LTF, CD79A, MMP1, CD40LG
15cytochalasin b459.2LTF, MPO, RNASE3, EPX
16epinephrine45 11 2411.1RNASE3, CD79A, TG, CD40LG
17ivig459.1TG, APOH, CD79A, CD40LG
18methacholine45 1110.1MPO, LTF, RNASE3, CD79A
19estrogen458.9TG, RNASE3, CD79A, APOH, LTF
20minocycline45 119.9NOS2, LTF, TIMP1, MMP9
21h2o2458.8MMP1, EPX, LTF, MPO, CTGF, CD79A
22vitamin a45 11 2410.8MMP1, MMP9, LTF, TIMP1
23leukotriene b445 60 2410.8EPX, RNASE3, MMP9, LTF, MPO
24mannose458.5APOH, NOD2, LTF, CD79A, TG
25vitamin b12458.5APOH, CD79A, TIMP1, MPO, LTF, CD40LG
26aspirin45 50 29 2411.5RNASE3, TIMP1, MMP1, CD40LG, APOH, CD79A
27p002458.5APOH, TIMP1, EPX, RNASE3, MMP9, CTGF
28ribavirin45 50 1110.4TIMP1, LTF, CD40LG, MMP1, MMP9
29nitric oxide45 11 2410.4RNASE3, EPX, NOS2, NOD2, MPO, CTGF
30cytochalasin d45 609.4MMP9, MMP1, LTF, TIMP1, CTGF
31histamine45 29 2410.3CD79A, MPO, RNASE3, LTF, TIMP1, EPX
32herbimycin a45 609.3TIMP1, MMP1, MMP9, NOS2, CD40LG
33cyclosporin a45 29 6010.2CD79A, TG, MMP1, RNASE3, CD40LG, LTF
34ascorbic acid45 249.2CD40LG, LTF, MPO, CD79A, MMP1, NOS2
35prednisolone45 29 1110.2CD79A, EPX, RNASE3, MPO, APOH, MMP1
36formaldehyde45 249.0EPX, CD79A, CD40LG, MMP9, MMP1, MPO
37curcumin458.0NOS2, MMP9, MMP1, CTGF, TIMP1
38fibrinogen457.9CTGF, MMP9, RNASE3, APOH, CD79A, CD40LG
39heparin45 29 11 2410.8APOH, TIMP1, RNASE3, EPX, CD79A, CD40LG
40serine457.7LTF, EPX, MMP1, MPO, CTGF, MMP9
41adenylate457.7TIMP1, LTF, CD40LG, RNASE3, MMP9, NOS2
42creatinine457.5TG, MMP1, RNASE3, EPX, CD79A, LTF
43paraffin457.1TG, MMP9, MMP1, MPO, CD79A, CD40LG
44hyaluronic acid45 248.1TIMP1, RNASE3, MMP1, MMP9, LTF, CD40LG
45dexamethasone45 50 29 119.9CTGF, LTF, CD79A, EPX, RNASE3, NOS2
46n acetylcysteine456.9NOS2, RNASE3, TIMP1, CTGF, MPO, LTF
47cysteine456.8TG, MMP1, CD79A, CTGF, TIMP1, EPX
48retinoic acid45 247.6MMP9, RNASE3, LTF, CD40LG, CD79A, CTGF
49lactate456.5CD40LG, CD79A, EPX, RNASE3, MMP1, MMP9
50vegf456.1TIMP1, APOH, LTF, TG, CTGF, MPO

GO Terms for genes affiliated with Collagenous Colitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055788.4MMP9, COL14A1, CTGF, MMP1
2extracellular spaceGO:0056157.1COL14A1, APOH, CTGF, MPO, CD40LG, MMP9
3extracellular regionGO:0055766.5TG, CTGF, COL14A1, MMP9, MMP1, TIMP1

Biological processes related to Collagenous Colitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:00222710.0NOD2, NOS2
2negative regulation of growth of symbiont in hostGO:0441309.9NOD2, MPO
3defense response to bacteriumGO:0427429.5NOD2, NOS2, LTF, RNASE3
4B cell proliferationGO:0421009.2CD79A, CD40LG
5collagen catabolic processGO:0305748.7COL14A1, MMP1, MMP9
6extracellular matrix disassemblyGO:0226178.4COL14A1, MMP9, MMP1, TIMP1
7extracellular matrix organizationGO:0301988.1COL14A1, TIMP1, MMP1, MMP9

Molecular functions related to Collagenous Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.7NOS2, EPX, MPO
2heparin bindingGO:0082018.9LTF, MPO, CTGF, APOH

Products for genes affiliated with Collagenous Colitis

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Collagenous Colitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet