MCID: CLL021
MIFTS: 38

Collagenous Colitis

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 50 52 14
Colitis, Collagenous 42 69
Microscopic Colitis, Collagenous Type 50

Classifications:



External Ids:

Disease Ontology 12 DOID:0060183
ICD10 33 K52.89
MeSH 42 D046729
NCIt 47 C27021
SNOMED-CT 64 19311003
UMLS 69 C0238067

Summaries for Collagenous Colitis

NIH Rare Diseases : 50 collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to clostridium difficile colitis and lymphocytic colitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3). The drugs Budesonide and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related phenotype is Increased shRNA abundance (Z-score > 2).

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 72 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 clostridium difficile colitis 24.6 CD79A CHGA CHGB COL14A1 EPX MPO
2 lymphocytic colitis 11.3
3 microscopic colitis 11.2
4 collagenous gastritis 11.2
5 colitis 10.8
6 glioblastoma multiforme 10.5 MPO RNASE3
7 primary syringomyelia 10.5 EPX RNASE3
8 cecum adenoma 10.4 EPX RNASE3
9 winchester syndrome 10.4 EPX RNASE3
10 lymphocytic gastritis 10.4 EPX RNASE3
11 eosinophilic enteropathy 10.4 EPX MPO
12 acute gonococcal prostatitis 10.4 EPX RNASE3
13 bulbomembranous urethral cancer 10.4 EPX MPO
14 supratentorial primitive neuroectodermal tumor 10.3 CHGA SCG2
15 leukocyte disease 10.3 EPX RNASE3
16 osteoblastoma 10.3 CHGA EPX
17 inflamed seborrheic keratosis 10.3 EPX RNASE3
18 ragweed sensitivity 10.3 MPO NOS2 RNASE3
19 benign mammary dysplasia 10.2 EPX RNASE3
20 glutamate decarboxylase deficiency 10.2 CHGA CHGB
21 mucositis 10.2
22 heart septal defect 10.2 CD79A RNASE3
23 cowden syndrome 3 10.2 CHGA CHGB
24 uveal epithelioid cell melanoma 10.2 CD79A RNASE3
25 crustacean allergy 10.1 CD79A RNASE3
26 balkan nephropathy 10.1 EPX RNASE3
27 apple allergy 10.1 CD79A RNASE3
28 epilepsy with generalized tonic-clonic seizures 10.1 CHGA CHGB
29 facial dermatosis 10.1 EPX MPO RNASE3
30 ulcerative colitis 10.1
31 colonic benign neoplasm 10.1 CD79A MPO
32 spontaneous ocular nystagmus 10.1 EPX RNASE3
33 arthritis 10.1
34 pseudohypoaldosteronism, type iid 10.1 EPX MPO RNASE3
35 focal embolic glomerulonephritis 10.1 CD79A MPO
36 partial circumpapillary choroid dystrophy 10.1 CD79A MPO
37 eosinophilic fasciitis 10.1 CD79A MPO
38 angiomyoma 10.1 CD79A RNASE3
39 uveitis 10.0 CD79A MPO
40 diarrhea 10.0
41 shigellosis 10.0 CD79A MPO
42 nut allergy 10.0 CD79A RNASE3
43 follicular mucinosis 10.0 CD79A MPO
44 dermatomycosis 10.0 CD79A MPO
45 pancreatic cystadenoma 10.0 CD79A MPO
46 postinflammatory pulmonary fibrosis 10.0 CD79A MPO
47 epidermolysis bullosa simplex superficialis 10.0 CD79A RNASE3
48 toxic myocarditis 10.0 CD79A MPO
49 chemical colitis 10.0 CD79A CHGA
50 ureteral lymphoma 10.0 CD79A RNASE3

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis

Symptoms & Phenotypes for Collagenous Colitis

GenomeRNAi Phenotypes related to Collagenous Colitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.64 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 CHGA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.64 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.64 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.64 CHGA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.64 CHGA MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CD79A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.64 CHGA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.64 CHGA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.64 MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.64 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.64 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 CD79A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.64 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 CD79A CHGA MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.64 CD79A

Drugs & Therapeutics for Collagenous Colitis

Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3 51333-22-3 63006 5281004
2 Anti-Asthmatic Agents Phase 3
3 Anti-Inflammatory Agents Phase 3
4 Autonomic Agents Phase 3
5 Bronchodilator Agents Phase 3
6 glucocorticoids Phase 3
7 Hormone Antagonists Phase 3
8 Hormones Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Respiratory System Agents Phase 3
12 Analgesics Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Antirheumatic Agents Phase 3
16 Mesalamine Phase 3 89-57-6
17 Pharmaceutical Solutions
18 Antacids
19 Anti-Ulcer Agents
20
Bismuth 7440-69-9 16682734 105143
21 Gastrointestinal Agents
22 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
2 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
4 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3 Budesonide;Placebo
5 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048
6 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
7 Treatment of Microscopic Colitis Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

Anatomical Context for Collagenous Colitis

MalaCards organs/tissues related to Collagenous Colitis:

39
Colon, Small Intestine, T Cells, Endothelial, Liver, Heart, Kidney

Publications for Collagenous Colitis

Articles related to Collagenous Colitis:

(show top 50) (show all 444)
id Title Authors Year
1
A case of collagenous colitis associated with novel oral anticoagulants use. ( 28260714 )
2017
2
Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis. ( 28275312 )
2017
3
Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study. ( 28469361 )
2017
4
Collagenous colitis presenting with skip lesions mimicking Crohn's disease and complicated by intestinal obstruction. ( 28682012 )
2017
5
Collagenous colitis: Requirement for high-dose budesonide as maintenance treatment. ( 28457904 )
2017
6
Spontaneous Tear after Insufflation: A Unique Finding of Collagenous Colitis. ( 28864270 )
2017
7
Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis. ( 28321159 )
2017
8
Letter: oral low-dose methotrexate for collagenous colitis. ( 27250588 )
2016
9
Optimal management of collagenous colitis: a review. ( 26929656 )
2016
10
Pseudomembranous Collagenous Colitis: A Case of Not-so-Microscopic Colitis. ( 28119938 )
2016
11
Automated image analysis in the study of collagenous colitis. ( 27114713 )
2016
12
Collagenous Colitis Refractory to Budesonide: is the Upper Gastrointestinal Tract Involved? ( 27557639 )
2016
13
Comparison of Clinical Features, Treatment and Outcomes of Collagenous Sprue, Celiac Disease and Collagenous Colitis. ( 27620860 )
2016
14
Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis. ( 27725290 )
2016
15
Immunological Differences between Lymphocytic and Collagenous Colitis. ( 26928959 )
2016
16
Collagenous colitis and Crohn's disease: Guilty or innocent bystander? ( 27474197 )
2016
17
Letter: oral low-dose methotrexate for collagenous colitis - authors' reply. ( 27250589 )
2016
18
Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea. ( 26854205 )
2016
19
Spontaneous colonic perforation: a rare complication of collagenous colitis. ( 27178398 )
2016
20
Tofacitinib Response in Juvenile Idiopathic Arthritis (JIA) and Collagenous Colitis. ( 27870773 )
2016
21
Smoking Status Influences Clinical Outcome in Collagenous Colitis. ( 26721941 )
2016
22
Collagenous colitis presenting as spontaneous perforation in an 80A year old woman: Report of a Case. ( 27716080 )
2016
23
Anti-PD1-induced collagenous colitis in a melanoma patient. ( 26990271 )
2016
24
DOP082. Genome-wide association identifies multiple collagenous colitis susceptibility loci. ( 25718298 )
2015
25
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. ( 26019474 )
2015
26
Severe acute kidney injury as a complication of collagenous colitis. ( 26561416 )
2015
27
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. ( 26525574 )
2015
28
Pseudomembranous variant of collagenous colitis. ( 26508688 )
2015
29
Microscopic (collagenous) colitis in a patient with a heart transplant. ( 26115392 )
2015
30
Collagenous colitis with mucosal ulcerations in a patient without nonsteroidal anti-inflammatory drug or lansoprazole use. ( 26130218 )
2015
31
Collagenous Colitis Associated with Protein-losing Enteropathy. ( 26568022 )
2015
32
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
33
P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis. ( 25717636 )
2015
34
Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. ( 26450480 )
2015
35
Collagenous colitis during treatment with fumaric acid esters. ( 25482705 )
2014
36
Collagenous colitis associated with protein losing enteropathy in a toddler. ( 25221677 )
2014
37
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. ( 24526204 )
2014
38
Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial. ( 25425655 )
2014
39
Clinical characteristics of collagenous colitis with linear ulcerations. ( 23560988 )
2014
40
Mucosal tears and colonic perforation in a patient with collagenous colitis. ( 24523187 )
2014
41
Acute onset collagenous colitis with unique endoscopic findings. ( 25610672 )
2014
42
Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. ( 25036565 )
2014
43
Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. ( 24440672 )
2014
44
An In Vitro Model to Evaluate the Impact of the Soluble Factors from the Colonic Mucosa of Collagenous Colitis Patients on T Cells: Enhanced Production of IL-17A and IL-10 from Peripheral CD4(+) T Cells. ( 25332518 )
2014
45
Narrow band imaging for diagnosis of collagenous colitis. ( 25092202 )
2014
46
Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222. ( 25164577 )
2014
47
O-018a88genome-wide association identifies multiple collagenous colitis susceptibility Loci. ( 25407172 )
2014
48
Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis. ( 23423580 )
2013
49
Collagenous colitis and ankylosing spondylitis. ( 24076177 )
2013
50
Collagenous colitis with mucosal tears in two proton pump inhibitors and non-steroidal naive patients who developed metachronous cancer. ( 23134231 )
2013

Variations for Collagenous Colitis

Expression for Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for Collagenous Colitis

GO Terms for Collagenous Colitis

Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 CHGA COL14A1 EPX MPO RNASE3 SCG2
2 extracellular region GO:0005576 9.5 CHGA CHGB COL14A1 EPX MPO RNASE3
3 endoplasmic reticulum lumen GO:0005788 9.43 CHGB COL14A1 SCG2
4 secretory granule GO:0030141 8.92 CHGA CHGB MPO SCG2

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 9.37 CHGA RNASE3
2 defense response to fungus GO:0050832 9.32 CHGA MPO
3 innate immune response in mucosa GO:0002227 9.26 NOS2 RNASE3
4 hydrogen peroxide catabolic process GO:0042744 9.16 EPX MPO
5 defense response to Gram-negative bacterium GO:0050829 8.96 CHGA NOS2
6 defense response to bacterium GO:0042742 8.92 CHGA MPO NOS2 RNASE3

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX MPO
2 heme binding GO:0020037 8.8 EPX MPO NOS2

Sources for Collagenous Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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