MCID: CLL021
MIFTS: 36

Collagenous Colitis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

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Aliases & Descriptions for Collagenous Colitis:

Name: Collagenous Colitis 11 46 13 48
Colitis, Collagenous 37 66
 
Microscopic Colitis, Collagenous Type 46

Classifications:



External Ids:

Disease Ontology11 DOID:0060183
ICD1028 K52.89
SNOMED-CT60 19311003
MeSH37 D046729
NCIt43 C27021

Summaries for Collagenous Colitis

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NIH Rare Diseases:46 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as colitis, collagenous, is related to polyarteritis nodosa and clostridium difficile colitis. An important gene associated with Collagenous Colitis is MPO (Myeloperoxidase). Affiliated tissues include colon, small intestine and t cells.

Disease Ontology:11 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:69 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1polyarteritis nodosa29.9CD79A, MPO
2clostridium difficile colitis25.0CD79A, CHGA, CHGB, COL14A1, EPX, MMP1
3colitis11.0
4lymphocytic colitis10.8
5microscopic colitis10.7
6paratyphoid fever10.5MPO, RNASE3
7collagenous gastritis10.5
8eosinophilic cystitis10.5EPX, MPO
9motor peripheral neuropathy10.4EPX, MPO
10olfactory neural tumor10.4EPX, MPO
11winchester syndrome10.4EPX, RNASE3
12cecum adenoma10.4EPX, RNASE3
13fungal gastritis10.4EPX, RNASE3
14osteoblastoma10.4CHGA, EPX
15benign meningioma10.4CD79A, MPO
16arteriosclerosis10.3CD79A, MPO
17chronic cystitis10.3CD79A, RNASE3
18proliferative glomerulonephritis10.3CD79A, MPO
19melanoacanthoma10.3EPX, RNASE3
20acquired thrombocytopenia10.3CD79A, MPO
21eosinophilic fasciitis10.3CD79A, MPO
22suppurative uveitis10.3CD79A, MPO
23chromoblastomycosis10.3CD79A, MPO
24crustacean allergy10.3CD79A, RNASE3
25glucosidase acid-1,4-alpha deficiency10.3CHGA, CHGB
26complex partial epilepsy10.3CD79A, MPO
27meibomian cyst10.3CD79A, MPO
28apple allergy10.3CD79A, RNASE3
29lung squamous cell carcinoma10.3CD79A, MPO
30yellow fever10.3CD79A, MPO
31pulmonary alveolar proteinosis10.3CD79A, MPO
32osteoclast-like giant cell neoplasm of the pancreas10.3CHGA, CHGB
33peanut allergy10.3CD79A, RNASE3
34gait apraxia10.3CD79A, RNASE3
35chemical colitis10.3CD79A, CHGA
36autoimmune neuropathy10.3CD79A, RNASE3
37kidney angiomyolipoma10.3CD79A, MPO
38loeffler syndrome10.2EPX, RNASE3
39vaginitis10.2CD79A, RNASE3
40blind hypotensive eye10.2EPX, RNASE3
41ulcerative colitis10.2
42geotrichosis10.2CD79A, RNASE3
43borst-jadassohn intraepidermal carcinoma10.2CD79A, RNASE3
44epidermolysis bullosa simplex superficialis10.2CD79A, RNASE3
45sporotrichosis10.2CD79A, RNASE3
46arthritis10.2
47sarcoid meningitis10.2CD79A, RNASE3
48intracortical osteogenic sarcoma10.2CD79A, CHGA
49diarrhea10.2
50biliary tract disease10.2CD79A, RNASE3

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms for Collagenous Colitis

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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BudesonidePhase 341151333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide MMX
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
Horacort
 
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
2MesalaminePhase 315689-57-6
3glucocorticoidsPhase 34756
4
Bismuth1197440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
5COLANutraceutical1824

Interventional clinical trials:

idNameStatusNCT IDPhase
1Budesonide for Maintenance Treatment of Collagenous ColitisCompletedNCT00180076Phase 3
2SOIBD Collagenous Colitis Maintenance StudyCompletedNCT01278082Phase 3
3Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous ColitisCompletedNCT00450086Phase 3
4Long-Term Treatment of Collagenous Colitis With BudesonideActive, not recruitingNCT00139165Phase 3
5Case-Control Study to Identify Risk Factors for Microscopic ColitisCompletedNCT01928667
6Usefulness of Chromoendoscopy in Diagnosing Microscopic ColitisRecruitingNCT01504048
7Treatment of Microscopic ColitisTerminatedNCT00184171

Search NIH Clinical Center for Collagenous Colitis


Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

34
Colon, Small intestine, T cells, Endothelial, Kidney, Heart, Liver

Animal Models for Collagenous Colitis or affiliated genes

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Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50)    (show all 433)
idTitleAuthorsYear
1
Anti-PD1-induced collagenous colitis in a melanoma patient. (26990271)
2016
2
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. (26019474)
2015
3
Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. (26450480)
2015
4
Acute onset collagenous colitis with unique endoscopic findings. (25610672)
2014
5
Clinical characteristics of collagenous colitis with linear ulcerations. (23560988)
2014
6
Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. (23200274)
2013
7
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
8
Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. (22658854)
2013
9
Collagenous colitis with mucosal tears in two proton pump inhibitors and non-steroidal naive patients who developed metachronous cancer. (23134231)
2013
10
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010. (22719191)
2012
11
Is smoking a risk factor for collagenous colitis? (21854096)
2011
12
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study. (21557718)
2011
13
Systemic sclerosis and collagenous colitis in a patient with retroperitoneal fibrosis. (21453186)
2011
14
Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. (20840672)
2010
15
NSAID-induced collagenous colitis. (21041266)
2010
16
Mucosal tear in collagenous colitis. (18691941)
2009
17
Lansoprazole-associated collagenous colitis: unique presentation, similar to ischemic colitis. (19866430)
2009
18
Interventions for treating collagenous colitis. (18425892)
2008
19
Colonic perforation as a complication of collagenous colitis in a series of 12 patients. (18702648)
2008
20
Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis. (18513560)
2008
21
Collagenous colitis in a Japanese woman: successful treatment with mesalazine. (18577853)
2008
22
Collagenous colitis: oral low-dose methotrexate for patients with difficult symptoms: long-term outcomes. (17845686)
2007
23
Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature. (17718794)
2007
24
Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis. (16373277)
2006
25
Interventions for treating collagenous colitis: a Cochrane Inflammatory Bowel Disease Group systematic review of randomized trials. (15571596)
2004
26
Fractured colon: an endoscopically distinctive lesion associated with colonic perforation following colonoscopy in patients with collagenous colitis. (15087693)
2004
27
Association of common variable immunodeficiency with atypical collagenous colitis. (12923382)
2003
28
Further report of familial occurrence of collagenous colitis. (12374242)
2002
29
Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. (11781276)
2002
30
Histamine content and histamine secretion of the colonic mucosa in patients with collagenous colitis. (12013399)
2002
31
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
32
Role of bile acids and bile acid binding agents in patients with collagenous colitis. (10644309)
2000
33
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
34
Collagenous colitis: a long-term follow-up study. (10755251)
1999
35
Olsalazine in collagenous colitis. (8031693)
1994
36
Collagenous colitis: an unusual endoscopic appearance. (8495846)
1993
37
Unusual endoscopic appearance of collagenous colitis. (8409306)
1993
38
Collagenous colitis in children. (8335221)
1993
39
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. (1361906)
1992
40
Diarrhoea caused by collagenous colitis. (2774620)
1989
41
Collagenous colitis. (3337067)
1988
42
Increased subepithelial collagen deposition is not specific for collagenous colitis. (3237709)
1988
43
Collagenous colitis with rapid response to sulphasalazine. (2901742)
1988
44
Collagenous colitis: physiologic and histopathologic studies in seven patients. (3789577)
1987
45
Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. (3610134)
1987
46
Microscopic and collagenous colitis: different names for the same condition? (3770384)
1986
47
Collagenous colitis--a relapsing and remitting disease. (3699568)
1986
48
Collagenous colitis: the clinical and morphological features. (7122380)
1982
49
Collagenous colitis: a distinctive and potentially reversible disorder. (7068925)
1982
50
Collagenous colitis: a case report and review of the literature. (7155639)
1982

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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GO Terms for genes affiliated with Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.7CHGA, CHGB, MPO
2extracellular spaceGO:00056158.6CHGA, COL14A1, MPO, RNASE3, SCG2

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hydrogen peroxide catabolic processGO:004274410.0EPX, MPO
2defense response to Gram-positive bacteriumGO:00508309.7CHGA, RNASE3
3defense response to fungusGO:00508329.6CHGA, MPO

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peroxidase activityGO:00046019.6EPX, MPO

Sources for Collagenous Colitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet