MCID: CLL021
MIFTS: 39

Collagenous Colitis malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

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Aliases & Descriptions for Collagenous Colitis:

Name: Collagenous Colitis 11 48 50 13
Colitis, Collagenous 39 68
 
Microscopic Colitis, Collagenous Type 48

Classifications:



External Ids:

Disease Ontology11 DOID:0060183
ICD1030 K52.89
SNOMED-CT62 19311003
MeSH39 D046729
NCIt45 C27021

Summaries for Collagenous Colitis

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NIH Rare Diseases:48 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. it is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. the exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. treatment for collagenous colitis varies depending on the symptoms and severity in each individual. in some cases, the condition resolves on its own. last updated: 6/20/2013

MalaCards based summary: Collagenous Colitis, also known as colitis, collagenous, is related to peritonitis and diversion colitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3). Affiliated tissues include colon, small intestine and t cells, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Disease Ontology:11 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia:71 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis29.8EPX, MPO
2diversion colitis29.3CD79A, CHGA
3lymphocytic colitis11.3
4microscopic colitis11.2
5collagenous gastritis11.2
6colitis10.8
7mucositis10.2
8amelogenesis imperfecta 1j10.2EPX, RNASE3
9spastic paraplegia 3a, autosomal dominant10.2EPX, RNASE3
10epidermoid brain tumor10.2EPX, MPO
11necrotizing gastritis10.2EPX, RNASE3
12appendix carcinoid tumor10.2EPX, RNASE3
13acute gonococcal prostatitis10.2EPX, RNASE3
14astrocytoma10.2MPO, RNASE3
15sm-ahnmd10.2CHGA, SCG2
16cartilage cancer10.1CHGA, EPX
17bare lymphocyte syndrome, type i10.1MPO, NOS2, RNASE3
18ethmoid sinusitis10.1EPX, RNASE3
19gmppa-cdg10.1CHGA, CHGB
20inflamed seborrheic keratosis10.1EPX, RNASE3
21ulcerative colitis10.1
22heart septal defect10.1CD79A, RNASE3
23mitochondrial complex ii deficiency10.1CHGA, CHGB
24penis basaloid carcinoma10.1CD79A, RNASE3
25arthritis10.1
26brown shrimp allergy10.1CD79A, RNASE3
27scalp dermatosis10.1EPX, MPO, RNASE3
28pediatric meningioma10.1CD79A, MPO
29glucocorticoid resistance10.1EPX, MPO, RNASE3
30apricot allergy10.1CD79A, RNASE3
31colonic benign neoplasm10.1CD79A, MPO
32eosinophilic fasciitis10.0CD79A, MPO
33diarrhea10.0
34subacute glomerulonephritis10.0CD79A, MPO
35dysentery10.0CD79A, MPO
36uveitis10.0CD79A, MPO
37intravascular angioleiomyoma10.0CD79A, RNASE3
38cyclotropia10.0CD79A, MPO
39dermatomycosis10.0CD79A, MPO
40orbit alveolar rhabdomyosarcoma10.0CD79A, RNASE3
41omsk hemorrhagic fever10.0CD79A, MPO
42retinal telangiectasia10.0CHGA, CHGB
43postinflammatory pulmonary fibrosis10.0CD79A, MPO
44pancreatic serous cystadenoma10.0CD79A, MPO
45rosacea conjunctivitis10.0CD79A, MPO
46immune-complex glomerulonephritis10.0CD79A, MPO
47eyelid neoplasm10.0CD79A, RNASE3
48lymphangiectasia, intestinal10.0CD79A, RNASE3
49vulvar disease9.9CD79A, MPO, RNASE3
50dislocation of ear ossicle9.9CD79A, MPO, RNASE3

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to collagenous colitis

Symptoms & Phenotypes for Collagenous Colitis

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GenomeRNAi Phenotypes related to Collagenous Colitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1928.8CD79A, CHGA, MPO

Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BudesonideapprovedPhase 343251333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide MMX
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
Horacort
 
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
2HormonesPhase 314415
3Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 313168
4Peripheral Nervous System AgentsPhase 323689
5Anti-Asthmatic AgentsPhase 33488
6Hormone AntagonistsPhase 313180
7Respiratory System AgentsPhase 34997
8glucocorticoidsPhase 35103
9Anti-Inflammatory AgentsPhase 310729
10Autonomic AgentsPhase 310150
11Bronchodilator AgentsPhase 32965
12MesalaminePhase 316489-57-6
13Anti-Inflammatory Agents, Non-SteroidalPhase 34443
14Antirheumatic AgentsPhase 310956
15AnalgesicsPhase 311733
16Analgesics, Non-NarcoticPhase 36501
17Pharmaceutical Solutions8192
18Gastrointestinal Agents8402
19
Bismuth1407440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
20Anti-Ulcer Agents1842
21Antacids1842
22ColaNutraceutical1946

Interventional clinical trials:

idNameStatusNCT IDPhase
1Long-Term Treatment of Collagenous Colitis With BudesonideUnknown statusNCT00139165Phase 3
2Budesonide for Maintenance Treatment of Collagenous ColitisCompletedNCT00180076Phase 3
3Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous ColitisCompletedNCT00450086Phase 3
4SOIBD Collagenous Colitis Maintenance StudyCompletedNCT01278082Phase 3
5Case-Control Study to Identify Risk Factors for Microscopic ColitisCompletedNCT01928667
6Usefulness of Chromoendoscopy in Diagnosing Microscopic ColitisRecruitingNCT01504048
7Treatment of Microscopic ColitisTerminatedNCT00184171

Search NIH Clinical Center for Collagenous Colitis


Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

36
Colon, Small intestine, T cells, Endothelial, Kidney, Heart, Liver

Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Smoking Status Influences Clinical Outcome in Collagenous Colitis. (26721941)
2016
2
Letter: oral low-dose methotrexate for collagenous colitis - authors' reply. (27250589)
2016
3
Immunological Differences between Lymphocytic and Collagenous Colitis. (26928959)
2016
4
Optimal management of collagenous colitis: a review. (26929656)
2016
5
Collagenous colitis presenting as spontaneous perforation in an 80A year old woman: Report of a Case. (27716080)
2016
6
Spontaneous colonic perforation: a rare complication of collagenous colitis. (27178398)
2016
7
Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis. (27725290)
2016
8
Letter: oral low-dose methotrexate for collagenous colitis. (27250588)
2016
9
Comparison of Clinical Features, Treatment and Outcomes of Collagenous Sprue, Celiac Disease and Collagenous Colitis. (27620860)
2016
10
Anti-PD1-induced collagenous colitis in a melanoma patient. (26990271)
2016
11
Automated image analysis in the study of collagenous colitis. (27114713)
2016
12
Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea. (26854205)
2016
13
Tofacitinib Response in Juvenile Idiopathic Arthritis (JIA) and Collagenous Colitis. (27870773)
2016
14
Collagenous colitis and Crohn's disease: Guilty or innocent bystander? (27474197)
2016
15
Collagenous Colitis Refractory to Budesonide: is the Upper Gastrointestinal Tract Involved? (27557639)
2016
16
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. (26637845)
2015
17
Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. (26450480)
2015
18
P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis. (25717636)
2015
19
Collagenous colitis with mucosal ulcerations in a patient without nonsteroidal anti-inflammatory drug or lansoprazole use. (26130218)
2015
20
Collagenous Colitis Associated with Protein-losing Enteropathy. (26568022)
2015
21
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. (26019474)
2015
22
DOP082. Genome-wide association identifies multiple collagenous colitis susceptibility loci. (25718298)
2015
23
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. (26525574)
2015
24
Microscopic (collagenous) colitis in a patient with a heart transplant. (26115392)
2015
25
Pseudomembranous variant of collagenous colitis. (26508688)
2015
26
Severe acute kidney injury as a complication of collagenous colitis. (26561416)
2015
27
Collagenous colitis associated with protein losing enteropathy in a toddler. (25221677)
2014
28
Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. (24440672)
2014
29
Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222. (25164577)
2014
30
Narrow band imaging for diagnosis of collagenous colitis. (25092202)
2014
31
An In Vitro Model to Evaluate the Impact of the Soluble Factors from the Colonic Mucosa of Collagenous Colitis Patients on T Cells: Enhanced Production of IL-17A and IL-10 from Peripheral CD4(+) T Cells. (25332518)
2014
32
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. (24526204)
2014
33
Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial. (25425655)
2014
34
Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. (25036565)
2014
35
Acute onset collagenous colitis with unique endoscopic findings. (25610672)
2014
36
Mucosal tears and colonic perforation in a patient with collagenous colitis. (24523187)
2014
37
Clinical characteristics of collagenous colitis with linear ulcerations. (23560988)
2014
38
O-018a88genome-wide association identifies multiple collagenous colitis susceptibility Loci. (25407172)
2014
39
Collagenous colitis during treatment with fumaric acid esters. (25482705)
2014
40
A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. (23539406)
2013
41
Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis. (23423580)
2013
42
Stable incidence of collagenous colitis and lymphocytic colitis in A9rebro, Sweden, 1999-2008: a continuous epidemiologic study. (23945183)
2013
43
Collagenous colitis in children and adolescents: study of 7 cases and literature review. (23348901)
2013
44
Protein-losing enteropathy associated with collagenous colitis cured by withdrawal of a proton pump inhibitor. (23728552)
2013
45
Lack of effect of methotrexate in budesonide-refractory collagenous colitis. (24039441)
2013
46
Collagenous colitis with mucosal tears in two proton pump inhibitors and non-steroidal naive patients who developed metachronous cancer. (23134231)
2013
47
Clinical features and treatment responses in pediatric lymphocytic and collagenous colitis. (23820404)
2013
48
Celiac disease and other autoimmune diseases in patients with collagenous colitis. (23800241)
2013
49
Cerebral demyelination in children with collagenous colitis. (23793315)
2013
50
Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. (22658854)
2013

Variations for Collagenous Colitis

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Expression for genes affiliated with Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for genes affiliated with Collagenous Colitis

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GO Terms for genes affiliated with Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.7CHGB, COL14A1, SCG2
2secretory granuleGO:00301418.5CHGA, CHGB, MPO, SCG2
3extracellular spaceGO:00056158.4CHGA, COL14A1, EPX, MPO, RNASE3, SCG2
4extracellular regionGO:00055768.0CHGA, CHGB, COL14A1, EPX, MPO, RNASE3

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antimicrobial humoral responseGO:001973010.3CHGA, RNASE3
2defense response to fungusGO:005083210.2CHGA, MPO
3defense response to Gram-negative bacteriumGO:005082910.1CHGA, NOS2
4hydrogen peroxide catabolic processGO:00427449.9EPX, MPO
5innate immune response in mucosaGO:00022279.8NOS2, RNASE3
6defense response to bacteriumGO:00427429.5CHGA, MPO, NOS2, RNASE3

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.6EPX, MPO, NOS2
2peroxidase activityGO:00046019.6EPX, MPO

Sources for Collagenous Colitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet