BDC
MCID: CLL002
MIFTS: 54

Collecting Duct Carcinoma (BDC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Collecting Duct Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 Collecting duct carcinoma is a renal cell carcinoma described as a rare and aggressive type of renal cell carcinoma. the cancerous cells form irregular tubes inside the tumor. collecting duct carcinoma is more common among young people and unfortunately is diagnosed in most cases when the cancer has metastasized (spread inside the body).

MalaCards: Collecting Duct Carcinoma, also known as collecting duct carcinoma of the kidney, is related to hepatitis and bladder carcinoma. An important gene associated with Collecting Duct Carcinoma is LZTS1 (leucine zipper, putative tumor suppressor 1). The compounds estradiol and indium have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and thyroid, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia:63 Bellini duct carcinoma (BDC, also known as low-grade collecting duct carcinoma and tubulocystic... more...

Aliases & Classifications for Collecting Duct Carcinoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
collecting duct carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

collecting duct carcinoma 8 42 10 48
collecting duct carcinoma of the kidney 42 60
renal medullary carcinoma 8 48
cdc 42 48
renal carcinoma, collecting duct type 8
carcinoma of renal collecting duct 8
renal collecting duct carcinoma 42
bellini duct carcinoma 48
brachydactyly type c 60
bellini carcinoma 48
bdc 48


External Ids:

Disease Ontology8 DOID:4464
NCIt39 C7572, C6194
MeSH34 D002292
SNOMED-CT via Orphanet57 128669006
SNOMED-CT56 128669006
UMLS via Orphanet61 C1266044
MESH via Orphanet35 D002292
ICD10 via Orphanet26 C64

Related Diseases for Collecting Duct Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Collecting Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4AMACR, AFP
2bladder carcinoma30.2KRT19, CDKN1B
3renal clear cell carcinoma30.2AMACR, MUC1, VHL
4papillary carcinoma30.2MUC1, CEACAM3, CDKN1B, KRT19, AMACR
5adenocarcinoma30.1CT49, AFP, TOP1, MUC1, VHL, AQP3
6brachydactyly10.7
7renal cell carcinoma10.6
8kidney disease10.4
9gonorrhea10.3
10cystic kidney10.3
11transitional cell carcinoma10.3
12renal cell carcinoma, clear cell, somatic10.3
13influenza10.2
14syphilis10.2
15bazex-dupre-christol syndrome10.2
16bone carcinoma10.1
17papillary renal cell carcinoma10.1
18sarcomatoid renal cell carcinoma10.1
19nephrolithiasis10.1
20end stage renal failure10.1
21polycystic kidney disease10.1
22adrenal carcinoma10.1
23in situ carcinoma10.1
24meningitis10.1
25paraplegia10.1
26renal pelvis carcinoma10.1
27renal pelvis transitional cell carcinoma10.1
28thyroiditis10.1
29rubella10.1
30hepatitis b10.1
31measles10.1
32tuberculosis10.1
33viral hepatitis10.1
34sickle cell anemia10.1
35proximal symphalangism10.1
36hepatic tuberculosis10.0
37chickenpox10.0
38mumps10.0
39brachydactyly type c10.0
40esophageal squamous cell carcinoma10.0LZTS1
41kidney rhabdoid cancer10.0RNF139
42gallbladder cancer10.0CEACAM3
43leiomyoma10.0FLCN
44hemangioma10.0VHL
45endometrial carcinoma10.0CDKN1B
46renal oncocytoma10.0FLCN
47sertoli cell tumor10.0MUC1
48von hippel-lindau disease10.0VHL
49thyroid cancer10.0KRT19, CDKN1B
50kidney cancer10.0VHL, FLCN

Graphical network of the top 20 diseases related to Collecting Duct Carcinoma:



Diseases related to collecting duct carcinoma

Clinical Features for Collecting Duct Carcinoma

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Drugs & Therapeutics for Collecting Duct Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Collecting Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Collecting Duct Carcinoma

Search NIH Clinical Center for Collecting Duct Carcinoma

Search CenterWatch for Collecting Duct Carcinoma

Genetic Tests for Collecting Duct Carcinoma

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Anatomical Context for Collecting Duct Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Collecting Duct Carcinoma:

32
Kidney, Bone, Thyroid, Salivary gland

Animal Models for Collecting Duct Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Collecting Duct Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5FLCN, AFP, OCRL, SMARCB1, AQP3, AMACR
2MP:00053709.0VHL, AMACR, OGG1, MUC1, CDKN1B, EIF6
3MP:00020068.9SMARCB1, VHL, OGG1, LZTS1, FLCN, AFP
4MP:00053788.3VHL, AMACR, FLCN, OCRL, CDKN1B, EIF6
5MP:00107688.3TOP1, FLCN, OGG1, AMACR, VHL, AFP

Publications for Collecting Duct Carcinoma

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Sources:
50PubMed
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Articles related to Collecting Duct Carcinoma:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Collecting duct carcinoma of the kidney: Imaging observations of a rare tumor. (24396480)
2014
2
Active targeted therapy for metastatic collecting duct carcinoma of the kidney: a case report and review of the literature. (23686671)
2013
3
Collecting duct renal cell carcinoma with the syndrome of inappropriate antidiuresis: an autopsy case report. (23924558)
2013
4
The multislice CT findings of renal carcinoma associated with XP11.2 translocation/TFE gene fusion and collecting duct carcinoma. (23446748)
2013
5
Thyroid transcription factor 1 expression in a case of renal collecting duct carcinoma. (22703591)
2012
6
Tubulocystic renal carcinoma (low grade collecting duct carcinoma). (23154610)
2012
7
Collecting duct carcinoma presenting uncommon metastatic features. (23235769)
2012
8
Metastatic collecting duct carcinoma of the kidney responded to sunitinib. (20686910)
2011
9
Metastatic collecting duct carcinoma of the kidney treated with sunitinib. (21752265)
2011
10
Retraction: Metastatic collecting duct carcinoma of the kidney treated with Sunitinib. (22024397)
2011
11
Sarcomatoid collecting duct carcinoma of kidney diagnosed with urine and renal pelvic lavage cytology. (20014307)
2010
12
Undiagnosed collecting duct carcinoma presenting as meningeal carcinomatosis and multiple bone metastases. (20686287)
2010
13
PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. (20463571)
2010
14
Inhibition of pleural metastasis of collecting duct carcinoma of the kidney by modified cytokine-induced killer cells: A case report and review of the literature. (22870094)
2010
15
Renal collecting duct carcinoma in a dog. (18587095)
2008
16
Renal collecting duct carcinoma and concomitant bladder urothelial carcinoma: a case report. (18364277)
2008
17
Extrarenal multiorgan metastases of collecting duct carcinoma of the kidney: a case series. (18798981)
2008
18
Collecting duct carcinoma with acquired cystic disease of the kidney in a long-term hemodialysis patient. (18184183)
2008
19
Collecting duct carcinoma associated with renal stones]. (17373248)
2007
20
Collecting duct carcinoma producing granulocyte-colony-stimulating factor (G-CSF). (17593104)
2007
21
Prospective multicenter phase II study of gemcitabine plus platinum salt for metastatic collecting duct carcinoma: results of a GETUG (Groupe d'Etudes des Tumeurs Uro-GAcnitales) study. (17437788)
2007
22
Collecting duct carcinoma arising from multicystic dysplastic kidney disease. (18947667)
2006
23
Collecting duct carcinoma of kidney producing alpha-fetoprotein. (16126361)
2005
24
Low-grade renal collecting duct carcinoma. A case report with histochemical, immunohistochemical, and ultrastructural study. (15692951)
2005
25
Cortically located collecting duct carcinoma. (15922425)
2005
26
Collecting duct carcinoma associated with oncocytoma. (16255793)
2005
27
Fine needle aspiration cytology of collecting duct carcinoma of the kidney: report of a case with distinctive features and differential diagnosis. (15581171)
2004
28
Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases. (15357873)
2004
29
Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case report. (15173927)
2004
30
Collecting duct carcinoma of the kidney: a clinicopathological study of 9 cases. (14501710)
2003
31
Sarcomatoid collecting duct carcinoma arising in the hemodialysis-associated acquired cystic kidney: an autopsy report. (12828612)
2003
32
Asynchronous collecting duct carcinoma of the kidney and pulmonary adenocarcinoma. A case report. (12597341)
2002
33
Review of collecting duct carcinoma with focus on clinical and pathobiological aspects. (12371157)
2002
34
A case of collecting duct carcinoma (Bellini duct carcinoma) producing carcinoembryonic antigen]. (11329960)
2001
35
Collecting duct carcinoma of the kidney: are imaging findings suggestive of the diagnosis? (11222193)
2001
36
Renal collecting duct carcinoma. Report of a case with cytologic findings on fine needle aspiration. (10833995)
2000
37
Collecting duct carcinoma arising in a solitary kidney: imaging findings. (10416089)
1999
38
Collecting duct carcinomas of the kidney: a comparative loss of heterozygosity study with clear cell renal cell carcinoma. (9625847)
1998
39
Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. (9372874)
1997
40
Collecting-duct carcinoma presenting as upper tract lesion with abnormal urine cytology. (9099549)
1997
41
Cytopathology of renal collecting duct carcinoma in urine sediment. (9143848)
1997
42
Collecting duct carcinoma of kidney: a cytological study and case report. (8872437)
1996
43
Renal collecting duct carcinoma in an 8-year-old child. (8611351)
1996
44
Cytologic findings of collecting duct carcinoma of the kidney. (8599913)
1995
45
Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. (7534117)
1995
46
Sarcomatoid collecting duct carcinoma: a clinicopathologic and immunohistochemical study of five cases. (7504649)
1993
47
Collecting duct carcinoma of the kidney. (8499979)
1993
48
Collecting duct carcinoma of the kidney: a case report and review of the literature. (1552595)
1992
49
Collecting duct carcinoma of the kidney. (2318486)
1990
50
Collecting duct carcinoma of the kidney. (3542784)
1986

Genetic Variations for Collecting Duct Carcinoma

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Expression for genes affiliated with Collecting Duct Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Collecting Duct Carcinoma

Search GEO for disease gene expression data for Collecting Duct Carcinoma.

Pathways for genes affiliated with Collecting Duct Carcinoma

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Compounds for genes affiliated with Collecting Duct Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.4AFP, CT49
2indium4410.3CEACAM3, MUC1
3galactose4410.3CEACAM3
410-hydroxycamptothecin4410.3TOP1, AFP
55-fluorocytosine4410.3AFP, CEACAM3
6silver4410.1AQP3, AFP, CT49
7chloride4410.1AMACR, OCRL, KRT19, AQP3
8irinotecan44 49 1112.1CEACAM3, AFP, TOP1
9gemcitabine44 49 1112.1TOP1, MUC1, CDKN1B
10folate4410.1VHL, OGG1, AFP, MUC1
11dmso4410.0OGG1, AFP, MUC1, CDKN1B
12cytosine44 2411.0VHL, OGG1, AFP, CEACAM3
13mucicarmine4410.0CEACAM3, MUC1
14hematoxylin4410.0AMACR, MUC1, KRT19, CEACAM3
15formaldehyde44 2411.0TOP1, MUC1, CDKN1B, KRT19
16b 7234410.0AFP, MUC1, KRT19, CEACAM3
17methotrexate44 49 1111.9CEACAM3, CDKN1B, MUC1, AFP
18actinomycin d449.9VHL, TOP1, AFP, MUC1, CDKN1B
19agar449.9CT49, TOP1, AFP, MUC1, CDKN1B
20glycogen44 2410.9VHL, AFP, MUC1, CDKN1B, KRT19
215fluorouracil449.9TOP1, AFP, MUC1, CDKN1B, CEACAM3
22paclitaxel44 49 1111.8TOP1, AFP, CDKN1B, KRT19
23cytarabine44 49 1111.8CDKN1B, MUC1, TOP1
24cisplatin44 49 59 1112.8TOP1, AFP, MUC1, CDKN1B, KRT19
25glucose449.7AMACR, MUC1, CDKN1B, KRT19, CEACAM3, AQP3
26creatinine449.7AFP, OCRL, MUC1, KRT19, CEACAM3, AQP3
27testosterone44 59 11 2412.7AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
28oligonucleotide449.6VHL, AMACR, OGG1, CT49, AFP, CDKN1B
29adriamycin449.6CEACAM3, OGG1, TOP1, AFP, MUC1, KRT19
30cholesterol44 28 11 2412.6AMACR, AFP, MUC1, CDKN1B, CEACAM3
31retinoic acid44 2410.5AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
32paraffin449.4AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
33oxygen44 2410.4VHL, OGG1, AFP, MUC1, CDKN1B, KRT19
34thymidine44 2410.4OGG1, CT49, AFP, MUC1, CDKN1B, KRT19
35doxorubicin44 49 1111.4TOP1, AFP, CDKN1B, CEACAM3
36progesterone44 59 28 11 2413.2AMACR, CT49, AFP, MUC1, CDKN1B, EIF6
37vegf449.2VHL, CT49, AFP, MUC1, CDKN1B, EIF6
38tyrosine449.1VHL, AMACR, AFP, MUC1, CDKN1B, EIF6
39serine449.1VHL, OGG1, CT49, AFP, MUC1, CDKN1B

GO Terms for genes affiliated with Collecting Duct Carcinoma

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16Gene Ontology
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Cellular components related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4OGG1, LZTS1, TOP1, CDKN1B, SMARCB1, VHL
2cytoplasmGO:0057378.1TPD52L1, AMACR, LZTS1, FLCN, AFP, OCRL

Molecular functions related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.7TPD52L1, OGG1, LZTS1, FLCN, TOP1, OCRL

Products for genes affiliated with Collecting Duct Carcinoma

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  • Antibodies
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Sources for Collecting Duct Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet