BDC
MCID: CLL002
MIFTS: 54

Collecting Duct Carcinoma (BDC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Collecting Duct Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 Collecting duct carcinoma is a renal cell carcinoma described as a rare and aggressive type of renal cell carcinoma. the cancerous cells form irregular tubes inside the tumor. collecting duct carcinoma is more common among young people and unfortunately is diagnosed in most cases when the cancer has metastasized (spread inside the body).

MalaCards: Collecting Duct Carcinoma, also known as collecting duct carcinoma of the kidney, is related to hepatitis and bladder carcinoma. An important gene associated with Collecting Duct Carcinoma is LZTS1 (leucine zipper, putative tumor suppressor 1). The compounds estradiol and indium have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and thyroid, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia:63 Bellini duct carcinoma (BDC, also known as low-grade collecting duct carcinoma and tubulocystic... more...

Aliases & Classifications for Collecting Duct Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
collecting duct carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

collecting duct carcinoma 8 42 10 48
collecting duct carcinoma of the kidney 42 60
renal medullary carcinoma 8 48
cdc 42 48
renal carcinoma, collecting duct type 8
carcinoma of renal collecting duct 8
renal collecting duct carcinoma 42
bellini duct carcinoma 48
brachydactyly type c 60
bellini carcinoma 48
bdc 48


External Ids:

Disease Ontology8 DOID:4464
NCIt39 C7572, C6194
MeSH34 D002292
SNOMED-CT via Orphanet57 128669006
SNOMED-CT56 128669006
UMLS via Orphanet61 C1266044
MESH via Orphanet35 D002292
ICD10 via Orphanet26 C64

Related Diseases for Collecting Duct Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Collecting Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4AMACR, AFP
2bladder carcinoma30.2KRT19, CDKN1B
3renal clear cell carcinoma30.2AMACR, MUC1, VHL
4papillary carcinoma30.2MUC1, CEACAM3, CDKN1B, KRT19, AMACR
5adenocarcinoma30.1CT49, AFP, TOP1, MUC1, VHL, AQP3
6brachydactyly10.7
7renal cell carcinoma10.6
8kidney disease10.4
9gonorrhea10.3
10cystic kidney10.3
11transitional cell carcinoma10.3
12renal cell carcinoma, clear cell, somatic10.3
13influenza10.2
14syphilis10.2
15bazex-dupre-christol syndrome10.2
16bone carcinoma10.1
17papillary renal cell carcinoma10.1
18sarcomatoid renal cell carcinoma10.1
19nephrolithiasis10.1
20end stage renal failure10.1
21polycystic kidney disease10.1
22adrenal carcinoma10.1
23in situ carcinoma10.1
24meningitis10.1
25paraplegia10.1
26renal pelvis carcinoma10.1
27renal pelvis transitional cell carcinoma10.1
28thyroiditis10.1
29rubella10.1
30hepatitis b10.1
31measles10.1
32tuberculosis10.1
33viral hepatitis10.1
34sickle cell anemia10.1
35proximal symphalangism10.1
36hepatic tuberculosis10.0
37chickenpox10.0
38mumps10.0
39brachydactyly type c10.0
40esophageal squamous cell carcinoma10.0LZTS1
41kidney rhabdoid cancer10.0RNF139
42gallbladder cancer10.0CEACAM3
43leiomyoma10.0FLCN
44hemangioma10.0VHL
45endometrial carcinoma10.0CDKN1B
46renal oncocytoma10.0FLCN
47sertoli cell tumor10.0MUC1
48von hippel-lindau disease10.0VHL
49thyroid cancer10.0KRT19, CDKN1B
50kidney cancer10.0VHL, FLCN

Graphical network of the top 20 diseases related to Collecting Duct Carcinoma:



Diseases related to collecting duct carcinoma

Clinical Features for Collecting Duct Carcinoma

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Drugs & Therapeutics for Collecting Duct Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Collecting Duct Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Collecting Duct Carcinoma

Search CenterWatch for Collecting Duct Carcinoma

Genetic Tests for Collecting Duct Carcinoma

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Anatomical Context for Collecting Duct Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Collecting Duct Carcinoma:

32
Kidney, Bone, Thyroid, Salivary gland

Animal Models for Collecting Duct Carcinoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Collecting Duct Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5FLCN, AFP, OCRL, SMARCB1, AQP3, AMACR
2MP:00053709.0VHL, AMACR, OGG1, MUC1, CDKN1B, EIF6
3MP:00020068.9SMARCB1, VHL, OGG1, LZTS1, FLCN, AFP
4MP:00053788.3VHL, AMACR, FLCN, OCRL, CDKN1B, EIF6
5MP:00107688.3TOP1, FLCN, OGG1, AMACR, VHL, AFP

Publications for Collecting Duct Carcinoma

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Sources:
50PubMed
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Articles related to Collecting Duct Carcinoma:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Renal collecting duct carcinoma with extensive coagulative necrosis mimicking anemic infarct: report of a case and the literature review. (23866935)
2013
2
The MSCT and MRI findings of collecting duct carcinoma. (23726725)
2013
3
Collecting duct carcinoma: a rare malignancy. (23575082)
2013
4
Collecting duct carcinoma of the kidney: a clinicopathological study of five cases. (23773436)
2013
5
Management of renal collecting duct carcinoma: a systematic review and the McMaster experience. (23737692)
2013
6
A case report of collecting duct carcinoma of the kidney coexistent with giant adrenal myelolipoma. (22511446)
2012
7
HER2 blockade in metastatic collecting duct carcinoma (CDC) of the kidney: a case report. (23207624)
2012
8
Immunohistochemical analysis of SMARCB1/INI-1 expression in collecting duct carcinoma. (21705046)
2011
9
Undiagnosed collecting duct carcinoma presenting as meningeal carcinomatosis and multiple bone metastases. (20686287)
2010
10
Influence of demographic factors on outcome of collecting duct carcinoma: a Surveillance, Epidemiology, and End Results (SEER) database analysis. (19692318)
2009
11
Sorafenib induces therapeutic response in a patient with metastatic collecting duct carcinoma of kidney. (19209019)
2009
12
Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. (19390420)
2009
13
Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. (18602672)
2008
14
Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study. (18652620)
2008
15
Sarcomatoid collecting-duct carcinoma of the kidney. (18272028)
2007
16
Prospective multicenter phase II study of gemcitabine plus platinum salt for metastatic collecting duct carcinoma: results of a GETUG (Groupe d'Etudes des Tumeurs Uro-GAcnitales) study. (17437788)
2007
17
Collecting duct carcinoma of the kidney: CT and pathologic correlation. (16266796)
2006
18
Synchronous collecting duct carcinoma and papillary renal cell carcinoma: a case report and review of the literature. (15816631)
2005
19
Collecting duct carcinoma of the renal medulla presenting with paraplegia. (16307319)
2005
20
Collecting duct carcinoma: an entity to be redefined? (15480763)
2004
21
Bilateral collecting duct carcinoma presenting with tumour associated nephritis and end-stage renal failure. A case report and review of the literature. (15338664)
2004
22
Collecting duct carcinoma of the kidney: a clinicopathological study of 9 cases. (14501710)
2003
23
The collecting duct carcinoma of the kidney: a cytogenetical study. (12767370)
2003
24
Sarcomatoid collecting duct carcinoma arising in the hemodialysis-associated acquired cystic kidney: an autopsy report. (12828612)
2003
25
Renal cell carcinoma, chromophobe type, with collecting duct carcinoma and sarcomatoid components. (12562294)
2003
26
Immunohistochemical study of bcl-2, p53 and Ki-67 expressions in collecting duct carcinoma of the kidney. Five cases and review of the literature on bcl-2, p53 and Ki-67 expressions in renal cell carcinoma and transitional cell carcinoma. (12119441)
2002
27
Collecting duct carcinoma with long survival treated by partial nephrectomy. (11442664)
2001
28
A case of collecting duct carcinoma (Bellini duct carcinoma) producing carcinoembryonic antigen]. (11329960)
2001
29
Long-term remission in a patient with metastatic collecting duct carcinoma treated with taxol/carboplatin and surgery. (11744492)
2001
30
Collecting duct carcinoma mixed with common renal cell carcinoma: analysis of morphological characteristics using lectin histochemistry. (11299805)
2001
31
Collecting-duct carcinoma of the kidney with prominent signet ring cell features. (11406666)
2001
32
Association of a renal papillary carcinoma with a low grade tumour of the collecting ducts. (11477121)
2001
33
Collecting duct carcinoma arising in a solitary kidney: imaging findings. (10416089)
1999
34
Sarcomatoid collecting duct carcinoma. (10320148)
1999
35
Bellini duct (collecting duct) carcinoma of the kidney. (10195859)
1998
36
Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation. (9683779)
1998
37
Collecting duct carcinoma of kidney. (9503506)
1998
38
Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. (9372874)
1997
39
Collecting duct carcinoma of the kidney: a report of three cases and review of the literature. (9423214)
1997
40
Collecting duct carcinoma of the kidney. (9642334)
1997
41
Retrospective evaluation of c-erbB-2 oncogene amplification using competitive PCR in collecting duct carcinoma of the kidney. (9186368)
1997
42
Bellini duct (collecting duct) carcinoma of the kidney. (8677593)
1996
43
Cytopathology of retrograde renal pelvis brush specimens: an analysis of 40 cases with emphasis on collecting duct carcinoma and low-intermediate grade transitional cell carcinoma. (8982587)
1996
44
Collecting duct carcinoma. An unusual renal tumour. (8936632)
1996
45
High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2. (8895762)
1996
46
Renal collecting duct carcinoma. Report of a case with urinary cytologic findings. (8091912)
1994
47
Fine-needle aspiration biopsy of renal collecting duct carcinoma. (7956666)
1994
48
Collecting duct carcinoma of the kidney. (8044515)
1994
49
Collecting duct carcinoma of the kidney. (8499979)
1993
50
Collecting duct carcinoma: cytogenetic characterization. (1505933)
1992

Genetic Variations for Collecting Duct Carcinoma

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Expression for genes affiliated with Collecting Duct Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Collecting Duct Carcinoma

Search GEO for disease gene expression data for Collecting Duct Carcinoma.

Pathways for genes affiliated with Collecting Duct Carcinoma

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Compounds for genes affiliated with Collecting Duct Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.4AFP, CT49
2indium4410.3CEACAM3, MUC1
3galactose4410.3CEACAM3
410-hydroxycamptothecin4410.3TOP1, AFP
55-fluorocytosine4410.3AFP, CEACAM3
6silver4410.1AQP3, AFP, CT49
7chloride4410.1AMACR, OCRL, KRT19, AQP3
8irinotecan44 49 1112.1CEACAM3, AFP, TOP1
9gemcitabine44 49 1112.1TOP1, MUC1, CDKN1B
10folate4410.1VHL, OGG1, AFP, MUC1
11dmso4410.0OGG1, AFP, MUC1, CDKN1B
12cytosine44 2411.0VHL, OGG1, AFP, CEACAM3
13mucicarmine4410.0CEACAM3, MUC1
14hematoxylin4410.0AMACR, MUC1, KRT19, CEACAM3
15formaldehyde44 2411.0TOP1, MUC1, CDKN1B, KRT19
16b 7234410.0AFP, MUC1, KRT19, CEACAM3
17methotrexate44 49 1111.9CEACAM3, CDKN1B, MUC1, AFP
18actinomycin d449.9VHL, TOP1, AFP, MUC1, CDKN1B
19agar449.9CT49, TOP1, AFP, MUC1, CDKN1B
20glycogen44 2410.9VHL, AFP, MUC1, CDKN1B, KRT19
215fluorouracil449.9TOP1, AFP, MUC1, CDKN1B, CEACAM3
22paclitaxel44 49 1111.8TOP1, AFP, CDKN1B, KRT19
23cytarabine44 49 1111.8CDKN1B, MUC1, TOP1
24cisplatin44 49 59 1112.8TOP1, AFP, MUC1, CDKN1B, KRT19
25glucose449.7AMACR, MUC1, CDKN1B, KRT19, CEACAM3, AQP3
26creatinine449.7AFP, OCRL, MUC1, KRT19, CEACAM3, AQP3
27testosterone44 59 11 2412.7AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
28oligonucleotide449.6VHL, AMACR, OGG1, CT49, AFP, CDKN1B
29adriamycin449.6CEACAM3, OGG1, TOP1, AFP, MUC1, KRT19
30cholesterol44 28 11 2412.6AMACR, AFP, MUC1, CDKN1B, CEACAM3
31retinoic acid44 2410.5AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
32paraffin449.4AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
33oxygen44 2410.4VHL, OGG1, AFP, MUC1, CDKN1B, KRT19
34thymidine44 2410.4OGG1, CT49, AFP, MUC1, CDKN1B, KRT19
35doxorubicin44 49 1111.4TOP1, AFP, CDKN1B, CEACAM3
36progesterone44 59 28 11 2413.2AMACR, CT49, AFP, MUC1, CDKN1B, EIF6
37vegf449.2VHL, CT49, AFP, MUC1, CDKN1B, EIF6
38tyrosine449.1VHL, AMACR, AFP, MUC1, CDKN1B, EIF6
39serine449.1VHL, OGG1, CT49, AFP, MUC1, CDKN1B

GO Terms for genes affiliated with Collecting Duct Carcinoma

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16Gene Ontology
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Cellular components related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4VHL, OGG1, LZTS1, TOP1, CDKN1B, SMARCB1
2cytoplasmGO:0057378.1AMACR, LZTS1, FLCN, AFP, OCRL, MUC1

Molecular functions related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.7TPD52L1, OGG1, LZTS1, FLCN, TOP1, OCRL

Products for genes affiliated with Collecting Duct Carcinoma

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  • Antibodies
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Sources for Collecting Duct Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet