BDC
MCID: CLL002
MIFTS: 48

Collecting Duct Carcinoma (BDC) malady

Nephrological, Cancer categories

Summaries for Collecting Duct Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 Collecting duct carcinoma is a renal cell carcinoma described as a rare and aggressive type of renal cell carcinoma. the cancerous cells form irregular tubes inside the tumor. collecting duct carcinoma is more common among young people and unfortunately is diagnosed in most cases when the cancer has metastasized (spread inside the body).

MalaCards: Collecting Duct Carcinoma, also known as collecting duct carcinoma of the kidney, is related to bladder carcinoma and renal clear cell carcinoma. An important gene associated with Collecting Duct Carcinoma is LZTS1 (leucine zipper, putative tumor suppressor 1). The compounds estradiol and indium have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and salivary gland, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia:64 Bellini duct carcinoma (BDC, also known as low-grade collecting duct carcinoma and tubulocystic... more...

Aliases & Classifications for Collecting Duct Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological


Characteristics (Orphanet epidemiological data):

49
collecting duct carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

collecting duct carcinoma 8 43 10 49
collecting duct carcinoma of the kidney 43 61
renal medullary carcinoma 8 49
cdc 43 49
renal carcinoma, collecting duct type 8
carcinoma of renal collecting duct 8
renal collecting duct carcinoma 43
bellini duct carcinoma 49
brachydactyly type c 61
bellini carcinoma 49
bdc 49


External Ids:

Disease Ontology8 DOID:4464
NCIt40 C7572, C6194
MeSH35 D002292
SNOMED-CT via Orphanet58 128669006
SNOMED-CT57 128669006
UMLS via Orphanet62 C1266044
MESH via Orphanet36 D002292
ICD10 via Orphanet26 C64

Related Diseases for Collecting Duct Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Collecting Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma30.2KRT19, CDKN1B
2renal clear cell carcinoma30.2VHL, AMACR, MUC1
3papillary carcinoma30.2AMACR, MUC1, CDKN1B, KRT19, CEACAM3
4adenocarcinoma30.2VHL, AMACR, OGG1, CT49, TOP1, AFP
5brachydactyly type c10.7
6brachydactyly type b10.7
7brachydactyly10.7
8tubulocystic carcinoma10.4
9gonorrhea10.3
10transitional cell carcinoma10.3
11renal cell carcinoma, clear cell, somatic10.3
12brachydactyly type d10.3
13hepatitis c10.3
14hepatitis d10.2
15syphilis10.2
16bazex-dupre-christol syndrome10.2
17bone carcinoma10.2
18papillary renal cell carcinoma10.2
19sarcomatoid renal cell carcinoma10.2
20nephrolithiasis10.2
21polycystic kidney disease10.2
22adrenal carcinoma10.2
23chromophobe renal cell carcinoma10.2
24clear cell renal cell carcinoma10.2
25papillary renal carcinoma10.2
26nephritis10.2
27rubella10.1
28measles10.1
29hepatitis a10.1
30tuberculosis10.1
31viral hepatitis10.1
32sickle cell anemia10.1
33horseshoe kidney10.1
34proximal symphalangism10.1
35chondrodysplasia10.1
36cyclosporiasis10.0
37chickenpox10.0
38mumps10.0
39arthritis10.0
40guillain-barr� syndrome10.0
41lead poisoning10.0
42new-onset refractory status epilepticus10.0
43esophageal squamous cell carcinoma10.0LZTS1
44kidney rhabdoid cancer10.0RNF139
45gallbladder cancer10.0CEACAM3
46leiomyoma10.0FLCN
47hemangioma10.0VHL
48endometrial carcinoma10.0CDKN1B
49renal oncocytoma10.0FLCN
50sertoli cell tumor10.0MUC1

Graphical network of the top 20 diseases related to Collecting Duct Carcinoma:



Diseases related to collecting duct carcinoma

Clinical Features for Collecting Duct Carcinoma

Drugs & Therapeutics for Collecting Duct Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Collecting Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Collecting Duct Carcinoma

Search NIH Clinical Center for Collecting Duct Carcinoma

Search CenterWatch for Collecting Duct Carcinoma

Genetic Tests for Collecting Duct Carcinoma

Anatomical Context for Collecting Duct Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Collecting Duct Carcinoma:

33
Kidney, Thyroid, Salivary gland, Adrenal gland

Animal Models for Collecting Duct Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Collecting Duct Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5FLCN, AFP, OCRL, SMARCB1, AQP3, AMACR
2MP:00053709.0VHL, AMACR, OGG1, MUC1, CDKN1B, EIF6
3MP:00020068.9SMARCB1, VHL, OGG1, LZTS1, FLCN, AFP
4MP:00053788.3VHL, AMACR, FLCN, OCRL, CDKN1B, EIF6
5MP:00107688.3TOP1, FLCN, OGG1, AMACR, VHL, AFP

Publications for Collecting Duct Carcinoma

Sources:
51PubMed
See all sources

Articles related to Collecting Duct Carcinoma:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Triple combination of bevacizumab, gemcitabine and platinum salt in metastatic collecting duct carcinoma. (24190963)
2013
2
Renal collecting duct carcinoma: report of a case with unusual imaging findings regarding renal function. (23771391)
2013
3
The MSCT and MRI findings of collecting duct carcinoma. (23726725)
2013
4
Collecting duct carcinoma: a rare malignancy. (23575082)
2013
5
Collecting duct carcinoma of the kidney: a clinicopathological study of five cases. (23773436)
2013
6
Salivary gland-type renal carcinoma, a subset of collecting duct carcinoma: case report and meta-analysis of the entity. (23339365)
2013
7
Management of renal collecting duct carcinoma: a systematic review and the McMaster experience. (23737692)
2013
8
Collecting duct carcinoma: a rare renal tumor. (22805397)
2012
9
A case report of collecting duct carcinoma of the kidney coexistent with giant adrenal myelolipoma. (22511446)
2012
10
Distal ureteral seeding metastasis of collecting duct carcinoma manifesting as deep vein thrombosis. (22513238)
2012
11
HER2 blockade in metastatic collecting duct carcinoma (CDC) of the kidney: a case report. (23207624)
2012
12
Metastatic collecting duct carcinoma of the kidney responded to sunitinib. (20686910)
2011
13
Immunohistochemical analysis of SMARCB1/INI-1 expression in collecting duct carcinoma. (21705046)
2011
14
Genetic alterations and chemosensitivity profile in newly established human renal collecting duct carcinoma cell lines. (19154479)
2009
15
Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. (19390420)
2009
16
Renal collecting duct carcinoma in a dog. (18587095)
2008
17
Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. (18602672)
2008
18
Salvage paclitaxel chemotherapy for metastatic collecting duct carcinoma of the kidney. (19046497)
2008
19
Collecting duct carcinoma: an incidental finding in a non functional kidney secondary to nephrolithiasis. (17432025)
2007
20
Collecting duct carcinoma of the kidney: a case report with variable immunohistochemistry. (17073252)
2006
21
Collecting duct carcinoma of the kidney: CT and pathologic correlation. (16266796)
2006
22
Synchronous collecting duct carcinoma and papillary renal cell carcinoma: a case report and review of the literature. (15816631)
2005
23
Low-grade renal collecting duct carcinoma. A case report with histochemical, immunohistochemical, and ultrastructural study. (15692951)
2005
24
Collecting duct carcinoma: an entity to be redefined? (15480763)
2004
25
Collecting duct carcinoma of the kidney with retroperitoneal lymph mass. (15074793)
2004
26
Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case report. (15173927)
2004
27
New cytological findings on fine-needle aspiration of renal collecting duct carcinoma. (14506682)
2003
28
Renal cell carcinoma, chromophobe type, with collecting duct carcinoma and sarcomatoid components. (12562294)
2003
29
Immunohistochemical study of bcl-2, p53 and Ki-67 expressions in collecting duct carcinoma of the kidney. Five cases and review of the literature on bcl-2, p53 and Ki-67 expressions in renal cell carcinoma and transitional cell carcinoma. (12119441)
2002
30
Active chemotherapy for collecting duct carcinoma of the kidney: a case report and review of the literature. (11815966)
2002
31
Collecting duct carcinoma of the kidney. (12492960)
2002
32
Collecting duct carcinoma with long survival treated by partial nephrectomy. (11442664)
2001
33
Long-term remission in a patient with metastatic collecting duct carcinoma treated with taxol/carboplatin and surgery. (11744492)
2001
34
Collecting duct carcinoma mixed with common renal cell carcinoma: analysis of morphological characteristics using lectin histochemistry. (11299805)
2001
35
Collecting duct carcinoma of the kidney associated with the sickle cell trait. (11501235)
2001
36
Collecting-duct carcinoma of the kidney with prominent signet ring cell features. (11406666)
2001
37
Sarcomatoid collecting duct carcinoma. (10320148)
1999
38
Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation. (9683779)
1998
39
Collecting duct carcinoma of kidney. (9503506)
1998
40
Collecting-duct carcinoma presenting as upper tract lesion with abnormal urine cytology. (9099549)
1997
41
Collecting duct carcinoma of the kidney: a report of three cases and review of the literature. (9423214)
1997
42
Renal collecting duct carcinoma. (9067114)
1997
43
Bellini duct (collecting duct) carcinoma of the kidney. (8677593)
1996
44
Cytopathology of retrograde renal pelvis brush specimens: an analysis of 40 cases with emphasis on collecting duct carcinoma and low-intermediate grade transitional cell carcinoma. (8982587)
1996
45
Collecting duct carcinoma. An unusual renal tumour. (8936632)
1996
46
High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2. (8895762)
1996
47
Renal collecting duct carcinoma. Report of a case with urinary cytologic findings. (8091912)
1994
48
Fine-needle aspiration biopsy of renal collecting duct carcinoma. (7956666)
1994
49
Collecting duct carcinoma of the kidney. (8044515)
1994
50
Collecting duct carcinoma of the kidney: a case report and review of the literature. (1552595)
1992

Genetic Variations for Collecting Duct Carcinoma

Expression for genes affiliated with Collecting Duct Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Collecting Duct Carcinoma

Search GEO for disease gene expression data for Collecting Duct Carcinoma.

Pathways for genes affiliated with Collecting Duct Carcinoma

Compounds for genes affiliated with Collecting Duct Carcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1estradiol45 11 2412.4AFP, CT49
2indium4510.3CEACAM3, MUC1
3galactose4510.3CEACAM3
410-hydroxycamptothecin4510.3TOP1, AFP
55-fluorocytosine4510.3AFP, CEACAM3
6silver4510.1AQP3, AFP, CT49
7chloride4510.1AMACR, OCRL, KRT19, AQP3
8irinotecan45 50 1112.1CEACAM3, AFP, TOP1
9gemcitabine45 50 1112.1TOP1, MUC1, CDKN1B
10folate4510.1VHL, OGG1, AFP, MUC1
11dmso4510.0OGG1, AFP, MUC1, CDKN1B
12cytosine45 2411.0VHL, OGG1, AFP, CEACAM3
13mucicarmine4510.0CEACAM3, MUC1
14hematoxylin4510.0AMACR, MUC1, KRT19, CEACAM3
15formaldehyde45 2411.0TOP1, MUC1, CDKN1B, KRT19
16b 7234510.0AFP, MUC1, KRT19, CEACAM3
17methotrexate45 50 1111.9CEACAM3, CDKN1B, MUC1, AFP
18actinomycin d459.9VHL, TOP1, AFP, MUC1, CDKN1B
19agar459.9CT49, TOP1, AFP, MUC1, CDKN1B
20glycogen45 2410.9VHL, AFP, MUC1, CDKN1B, KRT19
215fluorouracil459.9TOP1, AFP, MUC1, CDKN1B, CEACAM3
22paclitaxel45 50 1111.8TOP1, AFP, CDKN1B, KRT19
23cytarabine45 50 1111.8CDKN1B, MUC1, TOP1
24cisplatin45 50 60 1112.8TOP1, AFP, MUC1, CDKN1B, KRT19
25glucose459.7AMACR, MUC1, CDKN1B, KRT19, CEACAM3, AQP3
26creatinine459.7AFP, OCRL, MUC1, KRT19, CEACAM3, AQP3
27testosterone45 60 11 2412.7AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
28oligonucleotide459.6VHL, AMACR, OGG1, CT49, AFP, CDKN1B
29adriamycin459.6CEACAM3, OGG1, TOP1, AFP, MUC1, KRT19
30cholesterol45 29 11 2412.6AMACR, AFP, MUC1, CDKN1B, CEACAM3
31retinoic acid45 2410.5AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
32paraffin459.4AMACR, CT49, AFP, MUC1, CDKN1B, KRT19
33oxygen45 2410.4VHL, OGG1, AFP, MUC1, CDKN1B, KRT19
34thymidine45 2410.4OGG1, CT49, AFP, MUC1, CDKN1B, KRT19
35doxorubicin45 50 1111.4TOP1, AFP, CDKN1B, CEACAM3
36progesterone45 60 29 11 2413.2AMACR, CT49, AFP, MUC1, CDKN1B, EIF6
37vegf459.2VHL, CT49, AFP, MUC1, CDKN1B, EIF6
38tyrosine459.1VHL, AMACR, AFP, MUC1, CDKN1B, EIF6
39serine459.1VHL, OGG1, CT49, AFP, MUC1, CDKN1B

GO Terms for genes affiliated with Collecting Duct Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4VHL, OGG1, LZTS1, TOP1, CDKN1B, SMARCB1
2cytoplasmGO:0057378.1AMACR, LZTS1, FLCN, AFP, OCRL, MUC1

Molecular functions related to Collecting Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.7TPD52L1, OGG1, LZTS1, FLCN, TOP1, OCRL

Products for genes affiliated with Collecting Duct Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Collecting Duct Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet