MCID: CLN015
MIFTS: 43

Colon Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Colon Adenocarcinoma

About this section


Disease Ontology:9 A colon carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to gastric adenocarcinoma and leukemia. An important gene associated with Colon Adenocarcinoma is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are Oxidative Stress and AHR Pathway. The compounds urodilatin and dicoumarol have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Colon Adenocarcinoma

About this section
Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT
See all sources

Colon Adenocarcinoma, Aliases & Descriptions:

Name: Colon Adenocarcinoma 9 43
Adenocarcinoma of Colon 9 60
 
Colonic Adenocarcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:234
SNOMED-CT55 255082000
NCIt38 C4349

Related Diseases for Colon Adenocarcinoma

About this section

Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1gastric adenocarcinoma30.2ODC1, MUC2, S100A4
2leukemia30.2FUT4, NQO1, ODC1, TCN2, HPSE, AREG
3herpes simplex30.0UNG, TNFRSF6B, LGALS4
4adenocarcinoma30.0NQO1, TNFRSF6B, ODC1, MUC2, LGALS4, ACSL4
5hepatocellular carcinoma29.9NQO1, TNFRSF6B, MUC2, ACSL4, HPSE, AREG
6melanoma29.8NQO1, ODC1, HPSE, CALB2, S100A4, AREG
7stomach cancer29.4NQO1, TNFRSF6B, ODC1, MUC2, HPSE, CDX1
8breast cancer29.3NQO1, ODC1, MUC2, LGALS4, HPSE, S100A4
9adenoma28.8UGT1A6, NQO1, ODC1, MUC2, ACSL4, CALB2
10submucosal invasive colon adenocarcinoma10.3
11thyroiditis10.3
12cholangiocarcinoma10.2
13laryngitis10.2
14myeloid leukemia10.2
15peritonitis10.2
16hypoxia10.2
17endotheliitis10.2
18gallbladder cancer10.2MUC2, HPSE
19cystadenocarcinoma10.2AREG, MUC2
20gastrointestinal stromal tumor10.2
21peutz-jeghers syndrome10.2
22chronic lymphocytic leukemia10.2
23crohn's disease10.2
24hepatitis10.2
25neuroendocrine carcinoma10.2
26imperforate anus10.2
27cervicitis10.2
28prostatitis10.2
29rhabdomyosarcoma10.2
30vaginitis10.2
31benign mesothelioma10.1CALB2, FUT4
32pelger-huet anomaly10.1
33muir-torre syndrome10.1
34colorectal adenocarcinoma10.1
35cushing's syndrome10.1
36squamous cell carcinoma, head and neck10.1ODC1, HPSE, AREG
37pancreatic cancer10.1S100A4, HPSE, MUC2, TNFRSF6B
38bladder cancer, somatic10.0AREG, MUC2, ODC1
39medulloblastoma10.0
40pheochromocytoma10.0
41obesity10.0
42renal cell carcinoma10.0
43neurofibromatosis, type 110.0
44alopecia10.0
45gas gangrene10.0
46hemolytic anemia10.0
47liver cirrhosis10.0
48malt lymphoma10.0
49nephrolithiasis10.0
50renal oncocytoma10.0

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Symptoms for Colon Adenocarcinoma

About this section

Drugs & Therapeutics for Colon Adenocarcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

About this section

Anatomical Context for Colon Adenocarcinoma

About this section

MalaCards organs/tissues related to Colon Adenocarcinoma:

31
Colon, Liver, Lymph node, Lung, Thyroid, Myeloid, T cells, Prostate, Endothelial, Bone, Breast, B cells, Smooth muscle, Placenta, Nk cells, Pituitary

Animal Models for Colon Adenocarcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Colon Adenocarcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3MUC2, ACSL4, HPSE, NPR1, NPPC, CDX1
2MP:00053877.7NQO1, UNG, MUC2, S100A4, NPR1, AREG
3MP:00028737.7UNG, ODC1, ACSL4, CALB2, S100A4, CDX1
4MP:00053977.5CDX1, FUT4, NQO1, UNG, MUC2, ACSL4

Publications for Colon Adenocarcinoma

About this section

Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 685)
idTitleAuthorsYear
1
Metastatic colon adenocarcinoma to the placenta. (25551314)
2015
2
Expression and promoter methylation status of hMLH1, MGMT, APC, and CDH1 genes in patients with colon adenocarcinoma. (25908636)
2015
3
An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1: Case Report. (25850602)
2015
4
Gamma-secretase inhibitor does not modulate angiogenesis in colon adenocarcinoma in obese mice. (25773953)
2015
5
TNFI+ gene/protein in tumorigenesis of sporadic colon adenocarcinoma. (25102301)
2014
6
Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. (25051885)
2014
7
VEGF-C and VEGF-D overexpression is more common in left-sided and well-differentiated colon adenocarcinoma. (24173916)
2014
8
Distant ureteral metastasis from colon adenocarcinoma: report of a case and review of the literature. (24716082)
2014
9
Size- and dose-dependent toxicity of cellulose nanocrystals (CNC) on human fibroblasts and colon adenocarcinoma. (24856254)
2014
10
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
11
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor I^. (23339868)
2013
12
Paraneoplastic optic neuropathy and retinopathy associated with colon adenocarcinoma. (24093201)
2013
13
Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2. (23582141)
2013
14
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1I+,25-dihydroxyvitamin Da88 function in human colon adenocarcinoma LS180 cells. (22562045)
2012
15
Atypical presentation of colon adenocarcinoma: a case report. (22330123)
2012
16
Facial cutaneous metastasis of colon adenocarcinoma. (23089416)
2012
17
Progressive multiple cranial nerve palsies as the presenting symptom of meningeal carcinomatosis from occult colon adenocarcinoma. (22466842)
2012
18
Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. (21789651)
2011
19
Apple procyanidins activate apoptotic signaling pathway in human colon adenocarcinoma cells by a lipid-raft independent mechanism. (19666002)
2009
20
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. (19253370)
2009
21
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. (19470241)
2009
22
Activation of Notch signaling in human colon adenocarcinoma. (19020755)
2008
23
Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). (18507053)
2008
24
Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. (18541341)
2008
25
A novel dendritic cell-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model. (17275030)
2007
26
Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. (17971901)
2007
27
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. (17083937)
2006
28
Human Flt3 ligand from Pichia pastoris inhibits growth of lymphoma and colon adenocarcinoma in mice. (16528967)
2006
29
Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. (15546874)
2005
30
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
31
Functional expression of TWEAK in human colonic adenocarcinoma cells. (15586228)
2005
32
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma. (15613481)
2005
33
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. (15309463)
2005
34
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. (14578160)
2004
35
Marked survival prolongation of mice bearing a transplantable colon adenocarcinoma by treatment with radioactive platinum-[125I]histamine complex. Preliminary report. (15968596)
2004
36
Assembly and functional analysis of tight junction in a colon adenocarcinoma cell line: effect of glucose depletion. (12839342)
2003
37
Ribonucleotide reductase subunit one as gene therapy target: commentary re: M-Y. Cao et al., Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma. Clin. Cancer Res., 9: 4304-4308, 2003. (14555499)
2003
38
Liver transplantation for metastatic colon adenocarcinoma: report of a case with 10 years of follow-up without recurrence. (12802483)
2003
39
Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cells. (12590703)
2002
40
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. (12240936)
2002
41
Photodynamic effects of mTHPC on human colon adenocarcinoma cells: photocytotoxicity, subcellular localization and apoptosis. (12003131)
2002
42
Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line. (11921276)
2002
43
Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. (11478796)
2001
44
Dissemination of latent colon adenocarcinoma after laparoscopic cholecystectomy. (10604625)
1999
45
Functional heterogeneity of colonic adenocarcinoma mucins for inhibition of Entamoeba histolytica adherence to target cells. (9561779)
1998
46
Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. (9002470)
1997
47
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. (8549662)
1996
48
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29. (7695773)
1995
49
Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line. (1378304)
1992
50
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. (2032228)
1991

Variations for Colon Adenocarcinoma

About this section

Expression for genes affiliated with Colon Adenocarcinoma

About this section
Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

About this section

Pathways related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0NQO1, UGT1A6
2
Show member pathways
AhR pathway36
10.0NQO1, UGT1A6
3
Show member pathways
10.0NQO1, UGT1A6
4
Show member pathways
8.3HPSE, UGT1A6, FUT4, NQO1, TNFRSF6B, ODC1

Compounds for genes affiliated with Colon Adenocarcinoma

About this section

Compounds related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1urodilatin4310.3NPR1, NPPC
2dicoumarol4310.3ODC1, NQO1
38-bromo cgmp4310.3NPPC, NPR1
4ng-nitro-l-arginine4310.3ODC1, NPPC
5cobalamin43 2411.2TCN2, ODC1
6beta-naphthoflavone43 1211.1UGT1A6, NQO1
7uridine43 24 1212.1ODC1, UNG, UGT1A6
8thymidylate4310.0NQO1, UNG, ODC1
9gamma-glutamylcysteine43 24 1212.0ODC1, NQO1
10agarose439.9UNG, MUC2, HPSE
11carbohydrates439.8FUT4, ODC1, MUC2
12trifluoperazine43 28 49 1212.8UGT1A6, ODC1, S100A4
13glyceraldehyde 3-phosphate439.8UNG, ODC1, HPSE
14isoproterenol43 1210.8AREG, NPPC, ODC1
15folate439.7NQO1, UNG, ODC1, TCN2
16creatinine439.7NQO1, TCN2, HPSE, NPPC
17prostaglandin439.7AREG, NPPC, ODC1
18methotrexate49 43 1211.7MUC2, ODC1, NQO1
19dmso439.7UGT1A6, MUC2, LGALS4
20galactose439.6LGALS4, MUC2, FUT4
21chloramphenicol43 2 49 1212.6NQO1, ODC1, TCN2, LGALS4
225-aza-2deoxycytidine439.5MUC2, HPSE, S100A4, CDX1
235fluorouracil439.5NQO1, UNG, MUC2
24heparin43 28 24 1212.5ODC1, HPSE, NPPC, AREG
25forskolin43 49 1211.5AREG, NPPC, NPR1, MUC2
26flutamide43 59 1211.4ODC1, AREG
27nacl439.4UNG, HPSE, S100A4
28cycloheximide439.2NQO1, UNG, ODC1, TCN2, AREG
29polysaccharide439.1AREG, HPSE, LGALS4, FUT4
30cysteine439.1NQO1, ODC1, MUC2, LGALS4, NPR1, NPPC
31nitric oxide43 24 1211.0ODC1, HPSE, CALB2, NPR1, NPPC
32glutamate438.9UNG, ODC1, HPSE, CALB2, NPR1
33oligonucleotide438.8UNG, MUC2, HPSE, S100A4, AREG
34thymidine43 249.2UNG, ODC1, LGALS4, CALB2, NPPC, AREG
35testosterone43 59 24 1211.1UGT1A6, NQO1, ODC1, LGALS4, CALB2, NPPC
36progesterone43 28 59 24 1212.1MUC2, LGALS4, CALB2, S100A4, AREG
37serine438.0NQO1, UNG, ODC1, MUC2, LGALS4, HPSE
38steroid437.9LGALS4, ACSL4, HPSE, CALB2, S100A4, AREG
39tyrosine437.7ODC1, LGALS4, CALB2, S100A4, NPPC, AREG
40retinoic acid43 248.6UGT1A6, FUT4, ODC1, MUC2, LGALS4, S100A4
41calcium43 49 24 1210.5MUC2, LGALS4, HPSE, CALB2, S100A4, NPPC
42estrogen437.1AREG, NQO1, ODC1, MUC2, LGALS4, HPSE

GO Terms for genes affiliated with Colon Adenocarcinoma

About this section

Biological processes related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:000618210.0NPPC, NPR1
2positive regulation of cGMP biosynthetic processGO:003082810.0NPPC, NPR1
3receptor guanylyl cyclase signaling pathwayGO:00071689.9NPPC, NPR1
4regulation of blood vessel sizeGO:00508809.7NPR1, NPPC
5small molecule metabolic processGO:00442818.9HPSE, ACSL4, TCN2, ODC1, NQO1, UGT1A6

Products for genes affiliated with Colon Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Colon Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet