MCID: CLN015
MIFTS: 51

Colon Adenocarcinoma malady

Gastrointestinal diseases, Cancer diseases categories
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Summaries for Colon Adenocarcinoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is when cancer develops in... more...

MalaCards: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to adenocarcinoma and leukemia. An important gene associated with Colon Adenocarcinoma is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are AHR Pathway and Oxidative Stress. The compounds urodilatin and dicoumarol have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Colon Adenocarcinoma

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon adenocarcinoma 8 45
adenocarcinoma of colon 8 62
colonic adenocarcinoma 8


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Disease Ontology8 DOID:234
SNOMED-CT58 255082000
NCIt40 C4349

Related Diseases for Colon Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.6AREG, CDX1, NPPC, NPR1, CALB2, HPSE
2leukemia30.6NQO1, TCN2, ODC1, AREG, HPSE, FUT4
3melanoma30.3AREG, S100A4, ODC1, NQO1, CALB2, HPSE
4colon cancer30.3S100A4, MUC2, LGALS4, HPSE, CDX1, AREG
5hepatocellular carcinoma30.2ACSL4, HPSE, AREG, NQO1, TNFRSF6B, MUC2
6adenoma30.0NQO1, ACSL4, MUC2, ODC1, UGT1A6, NPR1
7gastric adenocarcinoma30.0MUC2, ODC1, S100A4
8herpes simplex30.0TNFRSF6B, LGALS4, UNG
9lung adenocarcinoma29.9NQO1, S100A4, CALB2
10stomach cancer29.8NQO1, TNFRSF6B, MUC2, HPSE, CDX1, AREG
11breast cancer29.8MUC2, AREG, NQO1, ODC1, S100A4, LGALS4
12thyroiditis10.3
13submucosal invasive colon adenocarcinoma10.2
14cholangiocarcinoma10.2
15laryngitis10.2
16hypoxia10.2
17endotheliitis10.2
18crohn's disease10.1
19neuroendocrine carcinoma10.1
20chronic myeloid leukemia10.1
21imperforate anus10.1
22peutz-jeghers syndrome10.1
23cervicitis10.1
24chronic lymphocytic leukemia10.1
25myeloid leukemia10.1
26peritonitis10.1
27prostatitis10.1
28rhabdomyosarcoma10.1
29vaginitis10.1
30b-cell chronic lymphocytic leukemia10.1
31colorectal adenocarcinoma10.1
32pelger-huet anomaly10.1
33cushing's syndrome10.1
34muir-torre syndrome10.1
35gallbladder cancer10.0MUC2, HPSE
36cystadenocarcinoma10.0AREG, MUC2
37benign mesothelioma10.0FUT4, CALB2
38pancreatic cancer10.0TNFRSF6B, S100A4, HPSE, MUC2
39bladder carcinoma10.0ODC1, MUC2, AREG
40teratocarcinoma10.0CALB2, ODC1, FUT4
41chagas disease10.0TCN2, ODC1
42intrahepatic cholestasis10.0
43gastrointestinal stromal tumor10.0
44lichen planus10.0
45nephrolithiasis10.0
46aortitis10.0
47osteomalacia10.0
48hypoglycemia10.0
49intussusception10.0
50ulcerative colitis10.0

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Symptoms for Colon Adenocarcinoma

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Drugs & Therapeutics for Colon Adenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

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Anatomical Context for Colon Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Colon Adenocarcinoma:

33
Colon, Liver, Lung, Lymph node, Thyroid, T cells, Endothelial, Prostate, Myeloid, B cells, Bone, Breast, Nk cells, Smooth muscle, Pituitary

Animal Models for Colon Adenocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Colon Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3MUC2, ACSL4, HPSE, NPR1, NPPC, CDX1
2MP:00053877.7NQO1, UNG, MUC2, S100A4, NPR1, AREG
3MP:00028737.7UNG, ODC1, ACSL4, CALB2, S100A4, CDX1
4MP:00053977.5CDX1, FUT4, NQO1, UNG, MUC2, ACSL4

Publications for Colon Adenocarcinoma

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52PubMed
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Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 650)
idTitleAuthorsYear
1
VEGF-C and VEGF-D overexpression is more common in left-sided and well-differentiated colon adenocarcinoma. (24173916)
2014
2
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
3
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor I^. (23339868)
2013
4
Paraneoplastic optic neuropathy and retinopathy associated with colon adenocarcinoma. (24093201)
2013
5
Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2. (23582141)
2013
6
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1I+,25-dihydroxyvitamin Da88 function in human colon adenocarcinoma LS180 cells. (22562045)
2012
7
Atypical presentation of colon adenocarcinoma: a case report. (22330123)
2012
8
Facial cutaneous metastasis of colon adenocarcinoma. (23089416)
2012
9
Progressive multiple cranial nerve palsies as the presenting symptom of meningeal carcinomatosis from occult colon adenocarcinoma. (22466842)
2012
10
Retracted: Luciferase-transfected colon adenocarcinoma cell line (DLD-1) for use in Orthotopic Xenotransplantation studies. (22809083)
2012
11
Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. (21789651)
2011
12
Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. (21779837)
2011
13
Apple procyanidins activate apoptotic signaling pathway in human colon adenocarcinoma cells by a lipid-raft independent mechanism. (19666002)
2009
14
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. (19253370)
2009
15
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. (19470241)
2009
16
Activation of Notch signaling in human colon adenocarcinoma. (19020755)
2008
17
Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). (18507053)
2008
18
Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. (18541341)
2008
19
The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines. (18781096)
2008
20
A novel dendritic cell-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model. (17275030)
2007
21
Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. (17971901)
2007
22
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. (17083937)
2006
23
Human Flt3 ligand from Pichia pastoris inhibits growth of lymphoma and colon adenocarcinoma in mice. (16528967)
2006
24
Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. (15546874)
2005
25
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
26
Functional expression of TWEAK in human colonic adenocarcinoma cells. (15586228)
2005
27
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma. (15613481)
2005
28
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. (15309463)
2005
29
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. (14578160)
2004
30
Marked survival prolongation of mice bearing a transplantable colon adenocarcinoma by treatment with radioactive platinum-[125I]histamine complex. Preliminary report. (15968596)
2004
31
Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: optical and ultrastructural study in the rat. (14654918)
2004
32
Assembly and functional analysis of tight junction in a colon adenocarcinoma cell line: effect of glucose depletion. (12839342)
2003
33
Ribonucleotide reductase subunit one as gene therapy target: commentary re: M-Y. Cao et al., Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma. Clin. Cancer Res., 9: 4304-4308, 2003. (14555499)
2003
34
Liver transplantation for metastatic colon adenocarcinoma: report of a case with 10 years of follow-up without recurrence. (12802483)
2003
35
Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cells. (12590703)
2002
36
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. (12240936)
2002
37
Photodynamic effects of mTHPC on human colon adenocarcinoma cells: photocytotoxicity, subcellular localization and apoptosis. (12003131)
2002
38
Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line. (11921276)
2002
39
Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. (11478796)
2001
40
Activation of K-ras and c-erbB-2 protooncogenes in human colonic adenocarcinomas]. (11471321)
2001
41
Apoptosis can be detected in attached colonic adenocarcinoma HT29 cells using annexin V binding, but not by TUNEL assay or sub-G0 DNA content. (10679732)
2000
42
Dissemination of latent colon adenocarcinoma after laparoscopic cholecystectomy. (10604625)
1999
43
Functional heterogeneity of colonic adenocarcinoma mucins for inhibition of Entamoeba histolytica adherence to target cells. (9561779)
1998
44
Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. (9002470)
1997
45
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. (8549662)
1996
46
Characterization of tumorigenic sub-lines from a poorly tumorigenic human colon-adenocarcinoma cell line. (8782656)
1996
47
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29. (7695773)
1995
48
De novo synthesis of type 1 lacto-series glycolipids in human colonic adenocarcinoma cells: efficient synthesis of the Le(a) antigen and absence of brefeldin A-induced inhibition of its synthesis in Colo 205 cells. (8373171)
1993
49
Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line. (1378304)
1992
50
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. (2032228)
1991

Variations for Colon Adenocarcinoma

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Expression for genes affiliated with Colon Adenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

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50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 30KEGG
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Pathways related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway38
10.0UGT1A6, NQO1
210.0NQO1, UGT1A6
3
Show member pathways
10.0NQO1, UGT1A6
4
Show member pathways
8.3ODC1, UGT1A6, FUT4, NQO1, HPSE, ACSL4

Compounds for genes affiliated with Colon Adenocarcinoma

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1urodilatin4510.3NPR1, NPPC
2dicoumarol4510.3ODC1, NQO1
38-bromo cgmp4510.3NPPC, NPR1
4ng-nitro-l-arginine4510.3ODC1, NPPC
5cobalamin45 2411.2TCN2, ODC1
6beta-naphthoflavone45 1111.1UGT1A6, NQO1
7uridine45 24 1112.1ODC1, UNG, UGT1A6
8thymidylate4510.0NQO1, UNG, ODC1
9gamma-glutamylcysteine45 24 1112.0ODC1, NQO1
10agarose459.9UNG, MUC2, HPSE
11carbohydrates459.8FUT4, ODC1, MUC2
12trifluoperazine45 29 51 1112.8UGT1A6, ODC1, S100A4
13glyceraldehyde 3-phosphate459.8UNG, ODC1, HPSE
14isoproterenol45 1110.8AREG, NPPC, ODC1
15folate459.7NQO1, UNG, ODC1, TCN2
16creatinine459.7NQO1, TCN2, HPSE, NPPC
17prostaglandin459.7AREG, NPPC, ODC1
18methotrexate51 45 1111.7MUC2, ODC1, NQO1
19dmso459.7UGT1A6, MUC2, LGALS4
20galactose459.6LGALS4, MUC2, FUT4
21chloramphenicol45 3 51 1112.6NQO1, ODC1, TCN2, LGALS4
225-aza-2deoxycytidine459.5MUC2, HPSE, S100A4, CDX1
235fluorouracil459.5NQO1, UNG, MUC2
24heparin45 29 24 1112.5ODC1, HPSE, NPPC, AREG
25forskolin45 51 1111.5AREG, NPPC, NPR1, MUC2
26flutamide45 61 1111.4ODC1, AREG
27nacl459.4UNG, HPSE, S100A4
28cycloheximide459.2NQO1, UNG, ODC1, TCN2, AREG
29polysaccharide459.1AREG, HPSE, LGALS4, FUT4
30cysteine459.1NQO1, ODC1, MUC2, LGALS4, NPR1, NPPC
31nitric oxide45 24 1111.0ODC1, HPSE, CALB2, NPR1, NPPC
32glutamate458.9UNG, ODC1, HPSE, CALB2, NPR1
33oligonucleotide458.8UNG, MUC2, HPSE, S100A4, AREG
34thymidine45 249.2UNG, ODC1, LGALS4, CALB2, NPPC, AREG
35testosterone45 61 24 1111.1UGT1A6, NQO1, ODC1, LGALS4, CALB2, NPPC
36progesterone45 29 61 24 1112.1MUC2, LGALS4, CALB2, S100A4, AREG
37serine458.0NQO1, UNG, ODC1, MUC2, LGALS4, HPSE
38steroid457.9LGALS4, ACSL4, HPSE, CALB2, S100A4, AREG
39tyrosine457.7ODC1, LGALS4, CALB2, S100A4, NPPC, AREG
40retinoic acid45 248.6UGT1A6, FUT4, ODC1, MUC2, LGALS4, S100A4
41calcium45 51 24 1110.5MUC2, LGALS4, HPSE, CALB2, S100A4, NPPC
42estrogen457.1AREG, NQO1, ODC1, MUC2, LGALS4, HPSE

GO Terms for genes affiliated with Colon Adenocarcinoma

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16Gene Ontology
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Biological processes related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0NPPC, NPR1
2positive regulation of cGMP biosynthetic processGO:03082810.0NPPC, NPR1
3receptor guanylyl cyclase signaling pathwayGO:0071689.9NPPC, NPR1
4regulation of blood vessel sizeGO:0508809.7NPPC, NPR1
5small molecule metabolic processGO:0442818.9TCN2, ODC1, NQO1, UGT1A6, HPSE, ACSL4

Products for genes affiliated with Colon Adenocarcinoma

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Sources for Colon Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet