MCID: CLN015
MIFTS: 49

Colon Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenocarcinoma

MalaCards integrated aliases for Colon Adenocarcinoma:

Name: Colon Adenocarcinoma 12 13 52 14
Adenocarcinoma of Colon 12 69
Adenocarcinoma of the Colon 12
Colonic Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:234
NCIt 47 C4349
SNOMED-CT 64 255082000
UMLS 69 C0338106

Summaries for Colon Adenocarcinoma

Disease Ontology : 12 A colon carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to hepatocellular carcinoma and keratosis palmoplantaris adenocarcinoma of the colon. An important gene associated with Colon Adenocarcinoma is RAD54L (RAD54 Like (S. Cerevisiae)), and among its related pathways/superpathways are Development HGF signaling pathway and Pathways in cancer. The drugs Benzocaine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Colon Adenocarcinoma

Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
id Related Disease Score Top Affiliating Genes
1 hepatocellular carcinoma 29.1 ABCB1 BAX CASP3 CDH1 CEACAM5 CTNNB1
2 keratosis palmoplantaris adenocarcinoma of the colon 12.0
3 submucosal invasive colon adenocarcinoma 11.8
4 adenocarcinoma 10.9
5 periosteal osteogenic sarcoma 10.8 CTNNB1 KRT20
6 col12a1-related muscle diseases 10.7 CASP3 TYMS
7 acute monocytic leukemia 10.7 ABCB1 NQO1 TYMS
8 intestine carcinoma in situ 10.7 CEACAM5 FUT4
9 hereditary persistence of fetal hemoglobin, klf1-related 10.7 MLH1 PTGS2
10 angioma serpiginosum 10.7 CDH1 KRT20
11 psoriasis 10.7 CASP3 MLH1
12 follicular basal cell carcinoma 10.6 CDH1 KRT20
13 ampulla of vater squamous cell carcinoma 10.6 CDH1 KRT20
14 urethra adenocarcinoma 10.6 CDH1 KRT20 PTGS2
15 verrucous papilloma 10.6 KRT20 MLH1 ODC1
16 prostate transitional cell carcinoma 10.6 CASP3 CDH1 KRT20
17 gorlin bushkell jensen syndrome 10.6 CDH1 CTNNB1 KRT20
18 orbital lymphangioma 10.6 CASP3 CDH1 PTGS2
19 pancreatic signet ring cell adenocarcinoma 10.6 CDH1 CTNNB1 KRT20
20 atrophic gastritis 10.6 CASP3 MLH1 PTGS2
21 dysembryoplastic neuroepithelial tumor 10.5 CDH1 KRT20 PTGS2
22 skin tag 10.5 ABCB1 CASP3 CTNNB1
23 tracheal disease 10.5 CASP3 CDH1 CTNNB1
24 microcystic meningioma 10.5 CEACAM5 FUT4 KRT20
25 prostate small cell carcinoma 10.5 CEACAM5 CTNNB1 KRT20
26 vulvar angiokeratoma 10.5 CEACAM5 FUT4
27 vulva squamous cell carcinoma 10.5 CEACAM5 KRT20
28 apocrine adenocarcinoma 10.5 CDH1 CTNNB1 KRT20
29 wolffian duct adenoma 10.5 CEACAM5 KRT20 MLH1
30 striated muscle rhabdoid tumor 10.5 ABCB1 CEACAM5 KRT20 TYMS
31 breast granular cell tumor 10.4 CDH1 CTNNB1 RAD54L
32 mesothelioma, somatic 10.4 CDH1 CEACAM5 KRT20
33 pyloric antrum cancer 10.4 CDH1 CEACAM5 MLH1
34 thyroid gland disease 10.4 CTNNB1 MLH1
35 pancreatic somatostatinoma 10.4 CDH1 CEACAM5 CTNNB1
36 childhood teratoma of the ovary 10.4 CDH1 KRT20
37 testicular trophoblastic tumor 10.4 CEACAM5 KRT20
38 congenital hypomyelination neuropathy 10.4 CTNNB1 MLH1 ODC1 PTGS2
39 villous adenoma 10.4 CASP3 CDH1 CTNNB1 PTGS2
40 male reproductive organ benign neoplasm 10.4 CEACAM5 CTNNB1 MLH1
41 benign shuddering attacks 10.3 CDH1 CEACAM5 MLH1
42 ectodermal dysplasia with natal teeth, turnpenny type 10.3 CDH1 CEACAM5 KRT20 PTGS2
43 hordeolum 10.3 CEACAM5 KRT20
44 rectum sarcoma 10.3 CEACAM5 KRT20 MLH1 TYMS
45 cystic basal cell carcinoma 10.3 CDH1 CEACAM5 FUT4 KRT20
46 avian influenza 10.3 CDH1 CEACAM5 FUT4 KRT20
47 bardet-biedl syndrome 10.3 CASP3 CDH1 CTNNB1 MLH1
48 sertoli-leydig cell tumor 10.2 CDH1 CTNNB1 MLH1 PTGS2
49 esophagus lymphoma 10.2 CASP3 CDH1 CTNNB1 KRT20 PTGS2
50 pineal region meningioma 10.2 CDH1 CEACAM5

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to Colon Adenocarcinoma

Symptoms & Phenotypes for Colon Adenocarcinoma

MGI Mouse Phenotypes related to Colon Adenocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 MLH1 NQO1 ODC1 PFKFB3 PTGS2 RAD54L
2 digestive/alimentary MP:0005381 9.76 ABCB1 CASP3 CDH1 CTNNB1 CTNND1 MLH1
3 endocrine/exocrine gland MP:0005379 9.61 MLH1 PTGS2 ABCB1 ACSL4 BAX CASP3
4 neoplasm MP:0002006 9.17 BAX CDH1 CTNNB1 CTNND1 MLH1 NQO1

Drugs & Therapeutics for Colon Adenocarcinoma

Drugs for Colon Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Zinc Approved Phase 4 7440-66-6 32051 23994
3 tannic acid Approved, Nutraceutical Phase 4
4 Hypoglycemic Agents Phase 4
5 insulin Phase 4
6 Insulin, Globin Zinc Phase 4
7
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
8
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
9
Cetuximab Approved Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
10
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
11
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
12
Levoleucovorin Approved Phase 3,Phase 2,Phase 1 68538-85-2
13
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
14
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
15
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
16
Raltitrexed Approved, Investigational Phase 3,Phase 2 112887-68-0 104758
17
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
18
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
19
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
20
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
21
Tegafur Approved Phase 3,Phase 2 17902-23-7 5386
22
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
23
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
24
Floxuridine Approved Phase 3,Phase 2,Phase 1 50-91-9 5790
25
Dalteparin Approved Phase 3 9005-49-6
26
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
27
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
29
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
30
Camptothecin Experimental Phase 3,Phase 2,Phase 1 7689-03-4
31
Doxil Approved June 1999 Phase 3,Phase 2 31703
32
Vatalanib Investigational Phase 3 212141-54-3 151194
33
Eniluracil Investigational Phase 3 59989-18-3
34 Alkylating Agents Phase 3,Phase 2,Phase 1
35 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
36 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
37 Anti-Bacterial Agents Phase 3,Phase 2
38 Antibiotics, Antitubercular Phase 3,Phase 2
39 Antidotes Phase 3,Phase 2,Phase 1
40 Antimetabolites Phase 3,Phase 2,Phase 1
41 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
42 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
43 Calcium, Dietary Phase 3,Phase 2,Phase 1
44 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
45 Micronutrients Phase 3,Phase 2,Phase 1,Early Phase 1
46 Mitomycins Phase 3,Phase 2
47 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
48 Protective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
49 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
50 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 282)

id Name Status NCT ID Phase Drugs
1 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Not yet recruiting NCT02746432 Phase 4 Hyper insulinemic euglycemic clamp
2 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
3 Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer Unknown status NCT00005979 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
4 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
5 Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00182715 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
6 Combination Chemotherapy in Treating Patients With Colon Cancer Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
7 Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00070213 Phase 3 FOLFOX regimen;capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
8 Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil Unknown status NCT00389870 Phase 3 cyclosporine;irinotecan hydrochloride
9 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;semaxanib
10 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
11 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
12 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer Unknown status NCT00003260 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
13 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00274872 Phase 2, Phase 3 fluorouracil;leucovorin calcium;oxaliplatin
14 Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer Unknown status NCT00482222 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
15 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver Unknown status NCT00002692 Phase 3 fluorouracil;isolated perfusion;leucovorin calcium
16 Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer Unknown status NCT00002893 Phase 3 fluorouracil;leucovorin calcium;raltitrexed
17 Edrecolomab in Treating Patients With Stage II Colon Cancer Completed NCT00002968 Phase 3
18 Liver Infusions of Fluorouracil in Treating Patients With Dukes' A, Dukes' B, or Dukes' C Colon Cancer Undergoing Surgery Completed NCT00427310 Phase 3 fluorouracil;sodium heparin
19 Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver Completed NCT00023868 Phase 3 FOLFIRI regimen;cisplatin;doxorubicin hydrochloride;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C
20 Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00003594 Phase 3 irinotecan;fluorouracil;leucovorin calcium;oxaliplatin
21 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3 Vatalanib
22 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3 Vatalanib
23 Combination Chemotherapy in Treating Patients With Stage III Colon Cancer Completed NCT00003835 Phase 3 leucovorin calcium;fluorouracil;irinotecan hydrochloride
24 Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer Completed NCT00079274 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil;Locally Directed Therapy
25 Celecoxib Combined With Fluorouracil and Leucovorin in Treating Patients With Resected Stage III Adenocarcinoma (Cancer) of the Colon Completed NCT00085163 Phase 3 celecoxib;fluorouracil;leucovorin calcium
26 Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery Completed NCT00660894 Phase 3 folinate calcium;tegafur-uracil;tegafur-gimeracil-oteracil potassium
27 Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery Completed NCT00265811 Phase 3 Folfox + Cetuximab;Folfox
28 High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer Completed NCT00004150 Phase 3 fluorouracil;leucovorin calcium
29 Combination Chemotherapy in Treating Patients With Resected Colon Cancer Completed NCT00378716 Phase 3 5-fluorouracil;leucovorin calcium;tegafur;uracil
30 Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer Completed NCT00002575 Phase 3
31 Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00392899 Phase 3 UFT adjuvant chemotherapy
32 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer Completed NCT00026273 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
33 Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer Completed NCT00064181 Phase 3 FOLFIRI regimen;capecitabine;celecoxib;fluorouracil;irinotecan hydrochloride;leucovorin calcium
34 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
35 Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer Completed NCT00003873 Phase 3 fluorouracil;eniluracil
36 Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases Completed NCT00268398 Phase 3 oxaliplatin, folinic acid, fluorouracil;oxaliplatin, irinotecan, folinic acid, fluorouracil
37 Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer Completed NCT00096278 Phase 3 oxaliplatin;leucovorin calcium;fluorouracil
38 Optimized Chemotherapy Followed by Maintenance With Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot be Removed by Surgery (DREAM) Completed NCT00265824 Phase 3 bevacizumab;bevacizumab, erlotinib
39 Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Completed NCT00004252 Phase 3 fluorouracil;leucovorin calcium;semaxanib
40 Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated Completed NCT00025337 Phase 3 oxaliplatin;leucovorin calcium;fluorouracil
41 Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer Completed NCT00062426 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
42 Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Completed NCT00303771 Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium
43 Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer Completed NCT00008060 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
44 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer Completed NCT00004885 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
45 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer Completed NCT00003287 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
46 PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study Completed NCT00911170 Phase 3 Pegfilgrastim;Placebo;Standard Chemotherapy
47 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed NCT01099449 Phase 3 calcium gluconate;magnesium sulfate;oxaliplatin
48 Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer Completed NCT00975897 Phase 2, Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
49 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00316914 Phase 3 calcium gluconate;magnesium sulfate
50 Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer Completed NCT00002716 Phase 3 dexamethasone;floxuridine;fluorouracil;leucovorin calcium

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

Anatomical Context for Colon Adenocarcinoma

MalaCards organs/tissues related to Colon Adenocarcinoma:

39
Colon, Liver, Lung, Testes, Endothelial, Breast, Lymph Node

Publications for Colon Adenocarcinoma

Articles related to Colon Adenocarcinoma:

(show top 50) (show all 790)
id Title Authors Year
1
Induction of Apoptosis and Cell Cycle Arrest by Flavokawain C on HT-29 Human Colon Adenocarcinoma via Enhancement of Reactive Oxygen Species Generation, Upregulation of p21, p27, and GADD153, and Inactivation of Inhibitor of Apoptosis Proteins. ( 28808400 )
2017
2
Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma. ( 28913972 )
2017
3
Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-I_B Signaling. ( 28726723 )
2017
4
Curcumin inhibits growth potential by G1 cell cycle arrest and induces apoptosis in p53-mutated COLO 320DM human colon adenocarcinoma cells. ( 28011386 )
2017
5
Metastatic colon adenocarcinoma has a significantly elevated expression of IL-10 compared to primary colon adenocarcinoma tumors. ( 28812429 )
2017
6
A case of sigmoid colon adenocarcinoma diagnosed as facial cutaneous metastasis for survival after operation for 37A months. ( 28776316 )
2017
7
PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways. ( 28938583 )
2017
8
Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study. ( 28850633 )
2017
9
Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice. ( 28810912 )
2017
10
18F-FDG PET/CT of Seminal Vesicle Metastasis From Ascending Colon Adenocarcinoma. ( 28005644 )
2017
11
Improved efficacy of hyperthermia by auraptene in human colon adenocarcinoma cells. ( 28915362 )
2017
12
Bioinformatics analysis of RNA-seq data revealed critical genes in colon adenocarcinoma. ( 28742206 )
2017
13
Thyroid Metastasis as First Manifestation of a Colon Adenocarcinoma With KRAS Mutation: Usefulness of 18F-FDG PET/CT. ( 28759522 )
2017
14
A microRNA expression signature as a predictor of survival for colon adenocarcinoma. ( 27881005 )
2017
15
Are All Mutations the Same? A Rare Case Report of Coexisting Mutually Exclusive KRAS and BRAF Mutations in a Patient with Metastatic Colon Adenocarcinoma. ( 28811946 )
2017
16
Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line. ( 28808378 )
2017
17
ANTIOXIDANT potential of Cheddar cheeses to tackle human colon adenocarcinoma (Caco-2) cells. ( 28728356 )
2017
18
TNF Signaling Through RIP1 Kinase Enhances SN38-induced Death in Colon Adenocarcinoma. ( 28087739 )
2017
19
Homeodomain Protein Transforming Growth Factor Beta-Induced Factor 2 Like, X-Linked Function in Colon Adenocarcinoma Cells ( 28843229 )
2017
20
Thyroid Metastasis as First Manifestation of a Colon Adenocarcinoma With KRAS Mutation: Usefulness of 18F-FDG PET/CT. ( 28872477 )
2017
21
Sclerosing mesenteritis mimicking metachronous peritoneal metastases from descending colon adenocarcinoma. ( 28764712 )
2017
22
Filamin A upregulation correlates with Snail-induced epithelial to mesenchymal transition (EMT) and cell adhesion but its inhibition increases the migration of colon adenocarcinoma HT29 cells. ( 28778796 )
2017
23
Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo. ( 28935257 )
2017
24
Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells. ( 26751572 )
2016
25
Photodynamic action of palmatine hydrochloride on colon adenocarcinoma HT-29 cells. ( 27181460 )
2016
26
Primula auriculata Extracts Exert Cytotoxic and Apoptotic Effects against HT-29 Human Colon Adenocarcinoma Cells. ( 27610172 )
2016
27
BRAFV600E Gene Mutation in Colonic Adenocarcinomas. Immunohistochemical Detection Using Tissue Microarray and Clinicopathologic Characteristics: An 86 Case Series. ( 25710585 )
2016
28
Difficult Diagnosis of Colon Adenocarcinoma Metastasis to Retina: A Case Report and Literature Review. ( 27489594 )
2016
29
Evaluation of lignan (-)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29). ( 26817788 )
2016
30
Pneumobilia Resulting From Choledochoduodenal Fistula Secondary to Metastatic Colon Adenocarcinoma. ( 26958563 )
2016
31
Maximizing the Therapeutic Efficacy of Imatinib Mesylate-Loaded Niosomes on Human Colon Adenocarcinoma Using Box-Behnken Design. ( 27544432 )
2016
32
Potent In vivo anti-cancer activity and stability of liposomes encapsulated with semi-purified Job's tear (Coix lacryma-jobi Linn.) extracts on human colon adenocarcinoma (HT-29) xenografted mice. ( 27169326 )
2016
33
Impact of Increased Visceral Fat Measured by CT on Colon Adenocarcinoma Stage. ( 27826814 )
2016
34
Effect of different concentrations of oxygen on expression of sigma 1 receptor and superoxide dismutases in human colon adenocarcinoma cell lines. ( 27829319 )
2016
35
Combination of Nimbolide and TNF-I+-Increases Human Colon Adenocarcinoma Cell Death through JNK-mediated DR5 Up- regulation. ( 27268643 )
2016
36
Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells. ( 27589771 )
2016
37
Co-expression of autophagic markers following photodynamic therapy in SW620 human colon adenocarcinoma cells. ( 27485939 )
2016
38
Glutaraldehyde-Mediated Synthesis of Asparaginase-Bound Maghemite Nanocomposites: Cytotoxicity against Human Colon Adenocarcinoma Cells. ( 27797224 )
2016
39
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. ( 27261575 )
2016
40
Modulation of transforming growth factora89I^ signaling transducers in colon adenocarcinoma cells induced by staphylococcal enterotoxin B. ( 26647993 )
2016
41
Integrins are not essential for entry of coxsackievirus A9 into SW480 human colon adenocarcinoma cells. ( 27756316 )
2016
42
Identification of Molecular Targets for Predicting Colon Adenocarcinoma. ( 26868022 )
2016
43
Presentation of multiple myeloma mimicking bone metastasis from colon adenocarcinoma: A case report and literature review. ( 26870352 )
2016
44
Single cutaneous metastasis of colon adenocarcinoma - Case report. ( 27579752 )
2016
45
Colonic Adenocarcinoma Presenting as Sigmoidorectal Intussusception: A Consideration for Intussusception Reduction. ( 27657559 )
2016
46
Serum availability affects expression of common house-keeping genes in colon adenocarcinoma cell lines: implications for quantitative real-time PCR studies. ( 27339468 )
2016
47
Modelling of survival of patients with colon adenocarcinoma based on multivariable analysis of the state of cancer cell nuclear apparatus. ( 27031719 )
2016
48
I^-Catenin Expression Regulates Cell Migration of Human Colonic Adenocarcinoma Cells Through Gelsolin. ( 27798885 )
2016
49
Antiproliferative effects on colon adenocarcinoma cells induced by co-administration of vitamin K1 and Lactobacillus rhamnosus GG. ( 27035094 )
2016
50
Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells. ( 28053959 )
2016

Variations for Colon Adenocarcinoma

ClinVar genetic disease variations for Colon Adenocarcinoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RAD54L NM_001142548.1(RAD54L): c.188C> A (p.Pro63His) single nucleotide variant Pathogenic rs121908688 GRCh37 Chromosome 1, 46715769: 46715769

Expression for Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for Colon Adenocarcinoma

Pathways related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 BAX CASP3 CDH1 CTNNB1 PTGS2
2 12.23 BAX CASP3 CDH1 CTNNB1 MLH1 PTGS2
3
Show member pathways
11.71 CDH1 CTNNB1 CTNND1
4 11.68 BAX CASP3 PTGS2
5 11.66 CDH1 CEACAM5 CTNNB1 CTNND1
6 11.65 BAX CASP3 CDH1 CTNNB1 MLH1 PTGS2
7 11.56 BAX CASP3 MLH1
8 11.54 CDH1 CTNNB1 CTNND1
9 11.43 CASP3 CTNNB1 PTGS2
10 11.3 CDH1 CTNNB1 CTNND1
11 11.29 BAX CASP3 CDH1 CTNNB1 ODC1 RAD54L
12 11.23 CDH1 CTNNB1 CTNND1
13
Show member pathways
11.21 ABCB1 MLH1 NQO1
14 11.18 CDH1 CTNNB1 CTNND1
15 11.06 CDH1 CTNNB1 CTNND1
16 10.79 ABCB1 BAX CASP3
17 10.76 ABCB1 PTGS2
18 10.67 CDH1 CTNNB1
19 10.54 ABCB1 BAX

GO Terms for Colon Adenocarcinoma

Cellular components related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 9.26 CDH1 CTNNB1
2 catenin complex GO:0016342 9.16 CDH1 CTNNB1
3 flotillin complex GO:0016600 8.96 CDH1 CTNNB1
4 cell periphery GO:0071944 8.8 BAX CTNNB1 FUT4

Biological processes related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.71 CASP3 NQO1 PTGS2 TYMS
2 kidney development GO:0001822 9.7 BAX CTNNB1 ODC1
3 single organismal cell-cell adhesion GO:0016337 9.69 CDH1 CTNNB1 CTNND1
4 response to organic substance GO:0010033 9.67 CASP3 CDH1 PTGS2
5 response to glucocorticoid GO:0051384 9.65 CASP3 PTGS2 TYMS
6 response to toxic substance GO:0009636 9.62 BAX CDH1 NQO1 TYMS
7 response to estradiol GO:0032355 9.56 CASP3 CTNNB1 NQO1 PTGS2
8 adherens junction organization GO:0034332 9.54 CDH1 CTNNB1 CTNND1
9 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.46 BAX CASP3
10 cellular response to indole-3-methanol GO:0071681 9.43 CDH1 CTNNB1
11 entry of bacterium into host cell GO:0035635 9.33 CDH1 CTNNB1 CTNND1
12 positive regulation of neuron apoptotic process GO:0043525 9.26 BAX CASP3 CTNNB1 NQO1
13 response to drug GO:0042493 9.17 ABCB1 CASP3 CDH1 CTNNB1 PTGS2 RAD54L

Sources for Colon Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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