MCID: CLN015
MIFTS: 50

Colon Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Colon Adenocarcinoma

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Disease Ontology:10 A colon carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to adenocarcinoma and leukemia. An important gene associated with Colon Adenocarcinoma is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are AHR Pathway and Oxidative Stress. The compounds urodilatin and dicoumarol have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Colon Adenocarcinoma

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 40NCIt, 57SNOMED-CT
See all sources

Colon Adenocarcinoma, Aliases & Descriptions:

Name: Colon Adenocarcinoma 10 45
Adenocarcinoma of Colon 10 62
 
Colonic Adenocarcinoma 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology10 DOID:234
SNOMED-CT57 255082000
NCIt40 C4349

Related Diseases for Colon Adenocarcinoma

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Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.9NQO1, TNFRSF6B, ODC1, MUC2, LGALS4, ACSL4
2leukemia30.7FUT4, NQO1, ODC1, TCN2, HPSE, AREG
3melanoma30.5NQO1, ODC1, HPSE, CALB2, S100A4, AREG
4hepatocellular carcinoma30.3NQO1, TNFRSF6B, MUC2, ACSL4, HPSE, AREG
5adenoma30.2UGT1A6, NQO1, ODC1, MUC2, ACSL4, CALB2
6gastric adenocarcinoma30.0ODC1, MUC2, S100A4
7herpes simplex30.0UNG, TNFRSF6B, LGALS4
8stomach cancer29.9NQO1, TNFRSF6B, ODC1, MUC2, HPSE, CDX1
9breast cancer29.9NQO1, ODC1, MUC2, LGALS4, HPSE, S100A4
10thyroiditis10.3
11cholangiocarcinoma10.2
12submucosal invasive colon adenocarcinoma10.2
13laryngitis10.2
14myeloid leukemia10.2
15peritonitis10.2
16hypoxia10.2
17endotheliitis10.2
18gastrointestinal stromal tumor10.2
19peutz-jeghers syndrome10.2
20chronic lymphocytic leukemia10.2
21crohn's disease10.2
22hepatitis10.2
23neuroendocrine carcinoma10.2
24imperforate anus10.2
25cervicitis10.2
26prostatitis10.2
27rhabdomyosarcoma10.2
28vaginitis10.2
29pelger-huet anomaly10.1
30muir-torre syndrome10.1
31colorectal adenocarcinoma10.1
32cushing's syndrome10.1
33gallbladder cancer10.0MUC2, HPSE
34cystadenocarcinoma10.0AREG, MUC2
35benign mesothelioma10.0CALB2, FUT4
36medulloblastoma10.0
37pheochromocytoma10.0
38obesity10.0
39renal cell carcinoma10.0
40neurofibromatosis, type 110.0
41alopecia10.0
42gas gangrene10.0
43hemolytic anemia10.0
44liver cirrhosis10.0
45malt lymphoma10.0
46nephrolithiasis10.0
47renal oncocytoma10.0
48ulcerative colitis10.0
49intrahepatic cholestasis10.0
50myelitis10.0

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Symptoms for Colon Adenocarcinoma

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Drugs & Therapeutics for Colon Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

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Anatomical Context for Colon Adenocarcinoma

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MalaCards organs/tissues related to Colon Adenocarcinoma:

33
Colon, Liver, Lymph node, Lung, Thyroid, Myeloid, T cells, Prostate, Endothelial, Bone, Breast, B cells, Smooth muscle, Placenta, Nk cells, Pituitary

Animal Models for Colon Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Colon Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3AREG, NPR1, MUC2, CDX1, ACSL4, NPPC
2MP:00053877.7FUT4, NQO1, UNG, MUC2, S100A4, AREG
3MP:00028737.7S100A4, ACSL4, CALB2, UNG, ODC1, CDX1
4MP:00053977.5FUT4, CDX1, NPR1, S100A4, HPSE, ACSL4

Publications for Colon Adenocarcinoma

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Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 685)
idTitleAuthorsYear
1
Metastatic colon adenocarcinoma to the placenta. (25551314)
2015
2
Expression and promoter methylation status of hMLH1, MGMT, APC, and CDH1 genes in patients with colon adenocarcinoma. (25908636)
2015
3
An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1: Case Report. (25850602)
2015
4
Gamma-secretase inhibitor does not modulate angiogenesis in colon adenocarcinoma in obese mice. (25773953)
2015
5
TNFI+ gene/protein in tumorigenesis of sporadic colon adenocarcinoma. (25102301)
2014
6
Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. (25051885)
2014
7
VEGF-C and VEGF-D overexpression is more common in left-sided and well-differentiated colon adenocarcinoma. (24173916)
2014
8
Distant ureteral metastasis from colon adenocarcinoma: report of a case and review of the literature. (24716082)
2014
9
Size- and dose-dependent toxicity of cellulose nanocrystals (CNC) on human fibroblasts and colon adenocarcinoma. (24856254)
2014
10
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
11
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor I^. (23339868)
2013
12
Paraneoplastic optic neuropathy and retinopathy associated with colon adenocarcinoma. (24093201)
2013
13
Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2. (23582141)
2013
14
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1I+,25-dihydroxyvitamin Da88 function in human colon adenocarcinoma LS180 cells. (22562045)
2012
15
Atypical presentation of colon adenocarcinoma: a case report. (22330123)
2012
16
Facial cutaneous metastasis of colon adenocarcinoma. (23089416)
2012
17
Progressive multiple cranial nerve palsies as the presenting symptom of meningeal carcinomatosis from occult colon adenocarcinoma. (22466842)
2012
18
Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. (21789651)
2011
19
Apple procyanidins activate apoptotic signaling pathway in human colon adenocarcinoma cells by a lipid-raft independent mechanism. (19666002)
2009
20
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. (19253370)
2009
21
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. (19470241)
2009
22
Activation of Notch signaling in human colon adenocarcinoma. (19020755)
2008
23
Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). (18507053)
2008
24
Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. (18541341)
2008
25
A novel dendritic cell-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model. (17275030)
2007
26
Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. (17971901)
2007
27
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. (17083937)
2006
28
Human Flt3 ligand from Pichia pastoris inhibits growth of lymphoma and colon adenocarcinoma in mice. (16528967)
2006
29
Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. (15546874)
2005
30
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
31
Functional expression of TWEAK in human colonic adenocarcinoma cells. (15586228)
2005
32
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma. (15613481)
2005
33
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. (15309463)
2005
34
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. (14578160)
2004
35
Marked survival prolongation of mice bearing a transplantable colon adenocarcinoma by treatment with radioactive platinum-[125I]histamine complex. Preliminary report. (15968596)
2004
36
Assembly and functional analysis of tight junction in a colon adenocarcinoma cell line: effect of glucose depletion. (12839342)
2003
37
Ribonucleotide reductase subunit one as gene therapy target: commentary re: M-Y. Cao et al., Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma. Clin. Cancer Res., 9: 4304-4308, 2003. (14555499)
2003
38
Liver transplantation for metastatic colon adenocarcinoma: report of a case with 10 years of follow-up without recurrence. (12802483)
2003
39
Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cells. (12590703)
2002
40
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. (12240936)
2002
41
Photodynamic effects of mTHPC on human colon adenocarcinoma cells: photocytotoxicity, subcellular localization and apoptosis. (12003131)
2002
42
Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line. (11921276)
2002
43
Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. (11478796)
2001
44
Dissemination of latent colon adenocarcinoma after laparoscopic cholecystectomy. (10604625)
1999
45
Functional heterogeneity of colonic adenocarcinoma mucins for inhibition of Entamoeba histolytica adherence to target cells. (9561779)
1998
46
Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. (9002470)
1997
47
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. (8549662)
1996
48
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29. (7695773)
1995
49
Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line. (1378304)
1992
50
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. (2032228)
1991

Variations for Colon Adenocarcinoma

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Expression for genes affiliated with Colon Adenocarcinoma

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Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

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Pathways related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway38
10.0UGT1A6, NQO1
210.0NQO1, UGT1A6
3
Show member pathways
10.0NQO1, UGT1A6
4
Show member pathways
8.3ODC1, UGT1A6, FUT4, NQO1, HPSE, ACSL4

Compounds for genes affiliated with Colon Adenocarcinoma

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Compounds related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1urodilatin4510.3NPPC, NPR1
2dicoumarol4510.3ODC1, NQO1
38-bromo cgmp4510.3NPPC, NPR1
4ng-nitro-l-arginine4510.3NPPC, ODC1
5cobalamin45 2611.2ODC1, TCN2
6beta-naphthoflavone45 1311.1NQO1, UGT1A6
7uridine45 26 1312.1UGT1A6, UNG, ODC1
8thymidylate4510.0NQO1, UNG, ODC1
9gamma-glutamylcysteine45 26 1312.0NQO1, ODC1
10agarose459.9UNG, MUC2, HPSE
11carbohydrates459.8MUC2, FUT4, ODC1
12trifluoperazine45 30 51 1312.8S100A4, ODC1, UGT1A6
13isoproterenol45 1310.8NPPC, ODC1, AREG
14glyceraldehyde 3-phosphate459.7UNG, ODC1, HPSE
15folate459.7ODC1, UNG, NQO1, TCN2
16creatinine459.7HPSE, TCN2, NQO1, NPPC
17prostaglandin459.7NPPC, ODC1, AREG
18methotrexate51 45 1311.7MUC2, ODC1, NQO1
19dmso459.7LGALS4, UGT1A6, MUC2
20flutamide45 61 1311.6ODC1, AREG
21galactose459.6MUC2, LGALS4, FUT4
22chloramphenicol45 3 51 1312.6LGALS4, NQO1, ODC1, TCN2
235-aza-2deoxycytidine459.5MUC2, CDX1, S100A4, HPSE
24heparin45 30 26 1312.5NPPC, HPSE, ODC1, AREG
25forskolin45 51 1311.5NPR1, NPPC, AREG, MUC2
26nacl459.4S100A4, UNG, HPSE
275fluorouracil459.3MUC2, UNG, NQO1
28cycloheximide459.2NQO1, AREG, ODC1, UNG, TCN2
29polysaccharide459.1HPSE, LGALS4, FUT4, AREG
30cysteine459.1NPPC, LGALS4, ODC1, NQO1, NPR1, MUC2
31nitric oxide45 26 1311.0ODC1, CALB2, NPPC, NPR1, HPSE
32glutamate458.9ODC1, CALB2, NPR1, UNG, HPSE
33oligonucleotide458.8MUC2, AREG, HPSE, S100A4, UNG
34thymidine45 269.2AREG, NPPC, CALB2, LGALS4, ODC1, UNG
35testosterone45 61 26 1311.1NPPC, AREG, UGT1A6, NQO1, ODC1, LGALS4
36progesterone45 30 61 26 1312.1MUC2, LGALS4, CALB2, S100A4, AREG
37serine458.0UNG, ODC1, MUC2, LGALS4, HPSE, NPR1
38steroid457.9ACSL4, LGALS4, CALB2, S100A4, AREG, HPSE
39tyrosine457.7S100A4, NPPC, CALB2, ODC1, LGALS4, AREG
40retinoic acid45 268.6AREG, CDX1, NPPC, UGT1A6, S100A4, LGALS4
41calcium45 51 26 1310.5CALB2, S100A4, NPPC, HPSE, LGALS4, MUC2
42estrogen457.1HPSE, NPR1, S100A4, CALB2, LGALS4, MUC2

GO Terms for genes affiliated with Colon Adenocarcinoma

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Biological processes related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:000618210.0NPPC, NPR1
2positive regulation of cGMP biosynthetic processGO:003082810.0NPPC, NPR1
3receptor guanylyl cyclase signaling pathwayGO:00071689.9NPPC, NPR1
4regulation of blood vessel sizeGO:00508809.7NPPC, NPR1
5small molecule metabolic processGO:00442818.9TCN2, ODC1, NQO1, UGT1A6, HPSE, ACSL4

Products for genes affiliated with Colon Adenocarcinoma

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Sources for Colon Adenocarcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet