MCID: CLN015
MIFTS: 48

Colon Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Colon Adenocarcinoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

MalaCards: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to adenocarcinoma and colon cancer. An important gene associated with Colon Adenocarcinoma is RPS3 (ribosomal protein S3). The compounds progesterone and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and liver.

Aliases & Classifications for Colon Adenocarcinoma

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon adenocarcinoma 8 44
adenocarcinoma of colon 8 60
colonic adenocarcinoma 8


External Ids:

Disease Ontology8 DOID:234
SNOMED-CT56 255082000
NCIt39 C4349

Related Diseases for Colon Adenocarcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0CEACAM5, CALB2, VIP, RPS3, S100A4, TNFRSF6B
2colon cancer30.9HPSE, CDX1, MUC2, TYMS, AREG, TNFRSF6B
3lung adenocarcinoma30.7CEACAM5, CEACAM7, KRT20, S100A4, CALB2
4leukemia30.6FUT4, EIF4E, HPSE, TYMS, AREG, RPS3
5gastric adenocarcinoma30.5VIP, S100A4, TYMS, MUC2, KRT20, CEACAM7
6melanoma30.4CALB2, S100A4, AREG, HPSE, EIF4E, CEACAM7
7adenoma30.4CEACAM5, CEACAM7, ACSL4, KRT20, SI, EIF4E
8hepatocellular carcinoma30.3VIP, TNFRSF6B, AREG, MUC2, HPSE, ACSL4
9cholangiocarcinoma30.3MUC2, EIF4E, KRT20, CEACAM5
10signet ring cell adenocarcinoma30.3MUC2, KRT20, CEACAM5
11squamous cell carcinoma30.1CALB2, S100A4, AREG, TYMS, MUC2, CDX1
12cervical adenocarcinoma30.1CALB2, KRT20, CEACAM7, CEACAM5
13stomach cancer29.9CDX1, MUC2, TYMS, AREG, TNFRSF6B, S100A4
14breast cancer29.9VIP, S100A4, AREG, TYMS, MUC2, HPSE
15herpes simplex29.9LGALS4, TNFRSF6B
16endometriosis29.9CALB2
17colonic disease10.4
18mucinous adenocarcinoma10.4
19colon mucinous adenocarcinoma10.4
20colon lymphoma10.2
21thyroiditis10.2
22submucosal invasive colon adenocarcinoma10.2
23adenocarcinoma in situ10.2
24laryngitis10.2
25crohn's disease10.1
26neuroendocrine carcinoma10.1
27colon squamous cell carcinoma10.1
28chronic myeloid leukemia10.1
29imperforate anus10.1
30colon signet ring adenocarcinoma10.1
31peutz-jeghers syndrome10.1
32anus adenocarcinoma10.1
33breast adenocarcinoma10.1
34cervicitis10.1
35chronic lymphocytic leukemia10.1
36hepatitis10.1
37myeloid leukemia10.1
38peritonitis10.1
39prostate adenocarcinoma10.1
40prostatitis10.1
41rhabdomyosarcoma10.1
42vaginitis10.1
43cushing's syndrome10.0
44muir-torre syndrome10.0
45pelger-huet anomaly10.0
46sebaceous adenocarcinoma10.0
47apocrine adenocarcinoma10.0
48rectum adenocarcinoma10.0
49colorectal cancer10.0S100A4, AREG, TYMS, MUC2, CDX1, SI
50non-small cell lung carcinoma10.0S100A4, AREG, TYMS, MUC2, HPSE, CEACAM7

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Clinical Features for Colon Adenocarcinoma

About this section

Drugs & Therapeutics for Colon Adenocarcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colon Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Search CenterWatch for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

About this section

Anatomical Context for Colon Adenocarcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Colon Adenocarcinoma:

32
Colon, Appendix, Liver, Lung, Lymph node, Breast, Prostate, Thyroid, T cells, Endothelial, Pancreas, Myeloid, B cells, Bone, Ovary, Smooth muscle, Pituitary, Cervix, Nk cells

Animal Models for Colon Adenocarcinoma or affiliated genes

About this section

Publications for Colon Adenocarcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Overall survival is improved in mucinous adenocarcinoma of the colon. (24425620)
2014
2
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor I^. (23339868)
2013
3
Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons. (23416875)
2013
4
Cellular uptake and imaging studies of glycosylated silica nanoprobe (GSN) in human colon adenocarcinoma (HT 29 cell line). (23986637)
2013
5
Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. (22227581)
2012
6
Metastatic Colon Adenocarcinoma Presenting as Left Preauricular Pain. (22766623)
2012
7
Clostridium septicum aortitis with associated sigmoid colon adenocarcinoma. (22304871)
2012
8
A case of colonic mucinous adenocarcinoma in 19-year-old male patient. (22741141)
2012
9
Immunolocalization of glycodelin in human adenocarcinoma of the lung, squamous cell carcinoma of the lung and lung metastases of colonic adenocarcinoma. (21168900)
2011
10
Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. (21617225)
2011
11
Interval signet-ring cell adenocarcinoma of the colon: missed or de novo? (21540911)
2011
12
Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma. (21645643)
2011
13
Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas. (20661223)
2010
14
The secretory pathway Ca(2+)-ATPase 1 is associated with cholesterol-rich microdomains of human colon adenocarcinoma cells. (20363212)
2010
15
Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. (20697252)
2010
16
Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. (19937855)
2010
17
The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines. (18781096)
2008
18
Synchronous occurrence of a primary colon adenocarcinoma and a gastric stromal tumor. A case report. (18299673)
2008
19
Matrix metalloproteinase-9 associated with heparan sulphate chains of GPI-anchored cell surface proteoglycans mediates motility of murine colon adenocarcinoma cells. (18216069)
2008
20
Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma. (18516322)
2008
21
Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage. (18657565)
2008
22
GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. (17062666)
2006
23
PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. (16215757)
2006
24
Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMP. (16648657)
2005
25
Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma. (15742415)
2005
26
Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines. (14872242)
2004
27
Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer. (15494722)
2004
28
Modality of cell death induced by Foscan-based photodynamic treatment in human colon adenocarcinoma cell line HT29. (14972017)
2004
29
Photodynamic effects of porphyrin and chlorin photosensitizers in human colon adenocarcinoma cells. (15336264)
2004
30
Expressions of hTERT, p53, c-erbB-2 and Bcl-2 in colonic adenocarcinoma mouse models with liver metastases: effects of classical traditional Chinese medicine prescriptions for promoting circulation and removing blood stasis]. (15257895)
2004
31
Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. (12819184)
2003
32
Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling. (14500354)
2003
33
A rare case of metastases to the maxillary sinus from sigmoid colon adenocarcinoma. (12417782)
2002
34
Human colon adenocarcinoma is associated with specific post-translational modifications of versican and decorin. (12385781)
2002
35
Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas. (11440966)
2001
36
Antiproliferative effects of nitrosulindac on human colon adenocarcinoma cell lines. (11396974)
2001
37
Antitumoral vaccination with granulocyte-macrophage colony-stimulating factor or interleukin-12-expressing DHD/K12 colon adenocarcinoma cells. (10830715)
2000
38
Multiple 'serrated adenocarcinomas' of the colon with a cell lineage common to metaplastic polyp and serrated adenoma. Case report of a new subtype of colonic adenocarcinoma with gastric differentiation. (10699993)
2000
39
Comparison of glycoprotein expression between ovarian and colon adenocarcinomas. (10506443)
1999
40
Colon adenocarcinoma and B-16 melanoma grow larger following laparotomy vs. pneumoperitoneum in a murine model. (9593237)
1998
41
Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft. (9225945)
1997
42
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. (9284816)
1997
43
Nimodipine as a modulator of resistance to doxorubicin in human colon-adenocarcinoma cells. (21541481)
1996
44
The effect of hyperthermia and verapamil on primary and metastatic colon adenocarcinoma cell-lines - inhibition of proliferation, cell-cycle distribution and onset of apoptosis. (21597835)
1995
45
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells. (8215392)
1993
46
Interaction between 5-fluorouracil, [6RS]leucovorin, and recombinant human interferon-alpha 2a in cultured colon adenocarcinoma cells. (1867955)
1991
47
Confocal microscopy as a tool to reveal the tridimensional organization of intracellular lumens and intercellular cysts in a human colon adenocarcinoma cell line. (2096999)
1990
48
Pathologic quiz case 1. Nasal papillomatosis (inverted papilloma); adenocarcinoma of the ethmoid sinus resembling colonic carcinoma. (3566957)
1987
49
Peutz-Jeghers syndrome and metastasising colonic adenocarcinoma. (6479688)
1984
50
Calcification and ossification in a mucinous adenocarcinoma of the colon; report of a case. (14039206)
1962

Genetic Variations for Colon Adenocarcinoma

About this section

Expression for genes affiliated with Colon Adenocarcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

About this section

Compounds for genes affiliated with Colon Adenocarcinoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.9EIF4E, CEACAM5, CEACAM7, LGALS4, KRT20, S100A4
2tyrosine4411.9VIP, CALB2, AREG, EIF4E, SI, KRT20
3calcium44 49 11 2414.8CEACAM5, AREG, EIF4E, CALB2, LGALS4, MUC2
4thymidine44 2412.8VIP, CALB2, AREG, TYMS, SI, LGALS4
5retinoic acid44 2412.8FUT4, CDX1, EIF4E, LGALS4, MUC2, CEACAM7
6polysaccharide4411.7LGALS4, HPSE, SI, TYMS, FUT4, CEACAM5
7vegf4411.6TYMS, VIP, AREG, HPSE, EIF4E, KRT20
8cysteine4411.6LGALS4, SI, EIF4E, MUC2, VIP, CEACAM5
9steroid4411.4EIF4E, CALB2, ACSL4, LGALS4, S100A4
10paraffin4411.4CEACAM5, CALB2, MUC2, SI, KRT20
11mucicarmine4411.3CEACAM7, CALB2, CEACAM5, KRT20
12glucose4411.3LGALS4, EIF4E, HPSE, MUC2, SI, CEACAM5
13b 7234411.3CEACAM7, CEACAM5, KRT20, CALB2
14hematoxylin4411.3CEACAM5, MUC2, CALB2, KRT20
15gefitinib44 49 1113.3AREG, TYMS, CEACAM7, CEACAM5
16carbohydrates4411.3MUC2, CEACAM5, SI, FUT4
175-aza-2deoxycytidine4411.2HPSE, CDX1, S100A4, MUC2
18estrogen4411.2CALB2, SI, CEACAM7
19butyrate4411.2CALB2, SI, CEACAM7
205fluorouracil4411.2MUC2, TYMS, CEACAM5, CEACAM7
21serine4411.2HPSE, LGALS4, EIF4E, MUC2, TYMS, AREG
22crcs4411.2CDX1, CEACAM5, MUC2
23testosterone44 59 11 2414.1CALB2, LGALS4, VIP, KRT20, AREG
24lactose44 1112.1FUT4, LGALS4, SI
25triiodothyronine4411.0LGALS4, CEACAM7, SI
262,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL1111.0EIF4E, CEACAM5
27n-acetylglucosamine4411.0FUT4, CEACAM5, HPSE
285-fluorocytosine4410.9TYMS, CEACAM5
29actinomycin d4410.9EIF4E, MUC2, AREG, CEACAM7
30galactose4410.9FUT4, LGALS4, MUC2
315-deoxy-5-fluorouridine4410.9TYMS, CEACAM5
32mitomycin c4410.8AREG, TYMS, CEACAM5
33oligonucleotide4410.8EIF4E, HPSE, MUC2, AREG, S100A4

GO Terms for genes affiliated with Colon Adenocarcinoma

About this section

Products for genes affiliated with Colon Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colon Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet