MCID: CLN015
MIFTS: 48

Colon Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Colon Adenocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

MalaCards: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to adenocarcinoma and colon cancer. An important gene associated with Colon Adenocarcinoma is RPS3 (ribosomal protein S3). The compounds progesterone and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and liver.

Aliases & Classifications for Colon Adenocarcinoma

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon adenocarcinoma 8 44
adenocarcinoma of colon 8 60
colonic adenocarcinoma 8


External Ids:

Disease Ontology8 DOID:234
SNOMED-CT56 255082000
NCIt39 C4349

Related Diseases for Colon Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0CEACAM5, CALB2, VIP, RPS3, S100A4, TNFRSF6B
2colon cancer30.9HPSE, CDX1, MUC2, TYMS, AREG, TNFRSF6B
3lung adenocarcinoma30.7CEACAM5, CEACAM7, KRT20, S100A4, CALB2
4leukemia30.6FUT4, EIF4E, HPSE, TYMS, AREG, RPS3
5gastric adenocarcinoma30.5VIP, S100A4, TYMS, MUC2, KRT20, CEACAM7
6melanoma30.4CALB2, S100A4, AREG, HPSE, EIF4E, CEACAM7
7adenoma30.4CEACAM5, CEACAM7, ACSL4, KRT20, SI, EIF4E
8hepatocellular carcinoma30.3VIP, TNFRSF6B, AREG, MUC2, HPSE, ACSL4
9cholangiocarcinoma30.3MUC2, EIF4E, KRT20, CEACAM5
10signet ring cell adenocarcinoma30.3MUC2, KRT20, CEACAM5
11squamous cell carcinoma30.1CALB2, S100A4, AREG, TYMS, MUC2, CDX1
12cervical adenocarcinoma30.1CALB2, KRT20, CEACAM7, CEACAM5
13stomach cancer29.9CDX1, MUC2, TYMS, AREG, TNFRSF6B, S100A4
14breast cancer29.9VIP, S100A4, AREG, TYMS, MUC2, HPSE
15herpes simplex29.9LGALS4, TNFRSF6B
16endometriosis29.9CALB2
17colonic disease10.4
18mucinous adenocarcinoma10.4
19colon mucinous adenocarcinoma10.4
20colon lymphoma10.2
21thyroiditis10.2
22submucosal invasive colon adenocarcinoma10.2
23adenocarcinoma in situ10.2
24laryngitis10.2
25crohn's disease10.1
26neuroendocrine carcinoma10.1
27colon squamous cell carcinoma10.1
28chronic myeloid leukemia10.1
29imperforate anus10.1
30colon signet ring adenocarcinoma10.1
31peutz-jeghers syndrome10.1
32anus adenocarcinoma10.1
33breast adenocarcinoma10.1
34cervicitis10.1
35chronic lymphocytic leukemia10.1
36hepatitis10.1
37myeloid leukemia10.1
38peritonitis10.1
39prostate adenocarcinoma10.1
40prostatitis10.1
41rhabdomyosarcoma10.1
42vaginitis10.1
43cushing's syndrome10.0
44muir-torre syndrome10.0
45pelger-huet anomaly10.0
46sebaceous adenocarcinoma10.0
47apocrine adenocarcinoma10.0
48rectum adenocarcinoma10.0
49colorectal cancer10.0S100A4, AREG, TYMS, MUC2, CDX1, SI
50non-small cell lung carcinoma10.0S100A4, AREG, TYMS, MUC2, HPSE, CEACAM7

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Clinical Features for Colon Adenocarcinoma

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Drugs & Therapeutics for Colon Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colon Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Search CenterWatch for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

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Anatomical Context for Colon Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Colon Adenocarcinoma:

32
Colon, Appendix, Liver, Lung, Lymph node, Breast, Prostate, Thyroid, T cells, Endothelial, Pancreas, Myeloid, B cells, Bone, Ovary, Smooth muscle, Pituitary, Cervix, Nk cells

Animal Models for Colon Adenocarcinoma or affiliated genes

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Publications for Colon Adenocarcinoma

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Sources:
50PubMed
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Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Infected colonic mass revealing a lung adenocarcinoma. (23182674)
2013
2
Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon. (24156073)
2013
3
Panitumumab-induced acneiform rash in a patient with metastatic colon adenocarcinoma. (23716858)
2013
4
Ghrelin induces apoptosis in colon adenocarcinoma cells via proteasome inhibition and autophagy induction. (23632965)
2013
5
Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. (23114923)
2013
6
Tumor location is a prognostic factor in poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon. (22052041)
2012
7
The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells. (22555452)
2012
8
Simultaneous occurrence of colonic adenocarcinoma and MALT lymphoma: A series of three cases. (22532883)
2012
9
Lysosomal exoglycosidases and cathepsin D in colon adenocarcinoma. (23111620)
2012
10
Maxillary verrucous carcinoma coincident with cervical lymph node metastasis of colon adenocarcinoma. (23113859)
2012
11
Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. (21779837)
2011
12
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases. (21626272)
2011
13
Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma. (21159664)
2011
14
Peptides from water buffalo cheese whey induced senescence cell death via ceramide secretion in human colon adenocarcinoma cell line. (20725925)
2011
15
NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines. (22118625)
2011
16
Synchronous colonic adenocarcinoma and renal oncocytoma: a case report and literature review. (21873728)
2011
17
The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis. (21636682)
2011
18
The effect of intravitreal bevacizumab treatment on choroidal metastasis of colon adenocarcinoma--case report. (19893587)
2010
19
Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas. (20029639)
2009
20
Isolation of Acremonium strictum from pleural fluid of a patient with colon adenocarcinoma. (18627474)
2009
21
Clear cell adenocarcinoma of the colon: a case report and review of literature. (18286700)
2008
22
TNM staging and T-cell receptor gamma expression in colon adenocarcinoma. Correlation with disease progression? (18705407)
2008
23
Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. (17498763)
2007
24
Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. (16886596)
2006
25
Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI). (17007842)
2006
26
Apoptosis induced by aspirin and 5-fluorouracil in human colonic adenocarcinoma cells. (15986848)
2005
27
Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma. (16143033)
2005
28
Differential influence of pentoxifylline on murine colon adenocarcinoma- and melanoma-derived metastatic tumor development in lungs. (15069556)
2004
29
A comparison of drug-treated and untreated HCT-116 human colon adenocarcinoma cells using a 2-D liquid separation mapping method based upon chromatofocusing PI fractionation. (12918970)
2003
30
Sodium butyrate inhibits cell growth and stimulates p21WAF1/CIP1 protein in human colonic adenocarcinoma cells independently of p53 status. (14690797)
2003
31
Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T. (12918105)
2003
32
C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. (11961668)
2002
33
Invasive papillary adenocarcinoma of the colon. (11979380)
2002
34
Anti-beta4 integrin antibodies enhance migratory and invasive abilities of human colon adenocarcinoma cells and their MMP-2 expression. (10709107)
2000
35
The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma. (11448057)
2000
36
Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). (10604957)
2000
37
Selective distribution of calretinin in adenocarcinomas of the human colon and adjacent tissues. (10366153)
1999
38
Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa. (10356986)
1999
39
Growth modification of human colon adenocarcinoma cells exposed to a low-frequency electromagnetic field. (10517264)
1999
40
Gastrocolic fistula due to adenocarcinoma of the colon: simulation of primary gastric leiomyosarcoma on CT. (10665346)
1999
41
Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform. (9854145)
1998
42
Low density lipoproteins and Lovastatin modulate the organ-specific transendothelial migration of primary and metastatic human colon adenocarcinoma cell lines in vitro. (9932605)
1998
43
Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer. (10211111)
1998
44
Adhesion of tumoricidal eosinophils to MCA-38 colon adenocarcinoma cells involves protein tyrosine kinase activation and is diminished by elevated cyclic AMP in the effector cell. (9824649)
1998
45
Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. (9002470)
1997
46
Comparative in vitro sensitivity of human cholangiocarcinoma and colon adenocarcinoma cells to anticancer agents. (9137435)
1997
47
Antibody penetration of tumor GS-7 xenografts in nude mice: a model for mucinous adenocarcinoma of the colon. (8758919)
1996
48
Mucinous adenocarcinoma of the colon metastatic to the intestinal mucosa. (8197571)
1994
49
Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation. (1377597)
1992
50
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency. (2344373)
1990

Genetic Variations for Colon Adenocarcinoma

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Expression for genes affiliated with Colon Adenocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

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Compounds for genes affiliated with Colon Adenocarcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.9CALB2, S100A4, AREG, MUC2, EIF4E, KRT20
2tyrosine4411.9VIP, CALB2, S100A4, AREG, EIF4E, SI
3calcium44 49 11 2414.8VIP, CALB2, S100A4, AREG, MUC2, HPSE
4thymidine44 2412.8VIP, CALB2, AREG, TYMS, SI, LGALS4
5retinoic acid44 2412.8S100A4, AREG, MUC2, CDX1, EIF4E, LGALS4
6polysaccharide4411.7AREG, TYMS, HPSE, SI, LGALS4, FUT4
7vegf4411.6VIP, AREG, TYMS, HPSE, EIF4E, KRT20
8cysteine4411.6VIP, TYMS, MUC2, EIF4E, SI, LGALS4
9steroid4411.4LGALS4, ACSL4, EIF4E, S100A4, CALB2
10paraffin4411.4CEACAM5, KRT20, SI, MUC2, CALB2
11mucicarmine4411.3CALB2, KRT20, CEACAM7, CEACAM5
12glucose4411.3MUC2, HPSE, EIF4E, SI, LGALS4, CEACAM5
13b 7234411.3CALB2, KRT20, CEACAM7, CEACAM5
14hematoxylin4411.3CALB2, MUC2, KRT20, CEACAM5
15gefitinib44 49 1113.3AREG, TYMS, CEACAM7, CEACAM5
16carbohydrates4411.3MUC2, SI, FUT4, CEACAM5
175-aza-2deoxycytidine4411.2S100A4, MUC2, CDX1, HPSE
18estrogen4411.2CEACAM7, SI, CALB2
19butyrate4411.2CEACAM7, SI, CALB2
205fluorouracil4411.2TYMS, MUC2, CEACAM7, CEACAM5
21serine4411.2VIP, AREG, TYMS, MUC2, HPSE, EIF4E
22crcs4411.2MUC2, CDX1, CEACAM5
23testosterone44 59 11 2414.1VIP, CALB2, AREG, KRT20, LGALS4
24lactose44 1112.1FUT4, LGALS4, SI
25triiodothyronine4411.0SI, LGALS4, CEACAM7
262,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL1111.0CEACAM5, EIF4E
27n-acetylglucosamine4411.0CEACAM5, FUT4, HPSE
285-fluorocytosine4410.9CEACAM5, TYMS
29actinomycin d4410.9CEACAM7, EIF4E, MUC2, AREG
30galactose4410.9FUT4, LGALS4, MUC2
315-deoxy-5-fluorouridine4410.9CEACAM5, TYMS
32mitomycin c4410.8CEACAM5, TYMS, AREG
33oligonucleotide4410.8S100A4, AREG, MUC2, HPSE, EIF4E

GO Terms for genes affiliated with Colon Adenocarcinoma

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Products for genes affiliated with Colon Adenocarcinoma

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Sources for Colon Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet