MCID: CLN015
MIFTS: 52

Colon Adenocarcinoma malady

Cancer diseases, Gastrointestinal diseases categories
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Summaries for Colon Adenocarcinoma

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Wikipedia:65 Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is the development of... more...

MalaCards based summary: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to gastric adenocarcinoma and leukemia. An important gene associated with Colon Adenocarcinoma is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy), and among its related pathways are Oxidative Stress and AHR Pathway. The compounds urodilatin and dicoumarol have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Disease Ontology:8 A colon carcinoma that derives from epithelial cells of glandular origin.

Aliases & Classifications for Colon Adenocarcinoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT
See all sources

Colon Adenocarcinoma, Aliases & Descriptions:

Name: Colon Adenocarcinoma 8 44
Adenocarcinoma of Colon 8 62
 
Colonic Adenocarcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:234
SNOMED-CT57 255082000
NCIt39 C4349

Related Diseases for Colon Adenocarcinoma

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Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1gastric adenocarcinoma30.2ODC1, MUC2, S100A4
2leukemia30.1FUT4, NQO1, ODC1, TCN2, HPSE, AREG
3herpes simplex30.0UNG, TNFRSF6B, LGALS4
4adenocarcinoma30.0NQO1, TNFRSF6B, ODC1, MUC2, LGALS4, ACSL4
5melanoma29.8NQO1, ODC1, HPSE, CALB2, S100A4, AREG
6lung adenocarcinoma29.7S100A4, CALB2, NQO1
7stomach cancer29.4NQO1, TNFRSF6B, ODC1, MUC2, HPSE, CDX1
8breast cancer29.3NQO1, ODC1, MUC2, LGALS4, HPSE, S100A4
9adenoma28.8UGT1A6, NQO1, ODC1, MUC2, ACSL4, CALB2
10colon cancer10.5
11thyroiditis10.3
12cholangiocarcinoma10.2
13hepatocellular carcinoma10.2
14submucosal invasive colon adenocarcinoma10.2
15laryngitis10.2
16peritonitis10.2
17hypoxia10.2
18endotheliitis10.2
19gallbladder cancer10.2MUC2, HPSE
20cystadenocarcinoma10.2AREG, MUC2
21chronic lymphocytic leukemia10.2
22crohn's disease10.2
23hepatitis10.2
24neuroendocrine carcinoma10.2
25gastrointestinal stromal tumor10.2
26imperforate anus10.2
27peutz-jeghers syndrome10.2
28cervicitis10.2
29prostatitis10.2
30rhabdomyosarcoma10.2
31vaginitis10.2
32benign mesothelioma10.1CALB2, FUT4
33muir-torre syndrome10.1
34colorectal adenocarcinoma10.1
35pelger-huet anomaly10.1
36cushing's syndrome10.1
37squamous cell carcinoma of the head and neck10.1ODC1, HPSE, AREG
38pancreatic cancer10.1S100A4, HPSE, MUC2, TNFRSF6B
39bladder carcinoma10.0AREG, MUC2, ODC1
40teratocarcinoma10.0FUT4, ODC1, CALB2
41alopecia10.0
42chronic myeloid leukemia10.0
43diabetes mellitus10.0
44gas gangrene10.0
45liver cirrhosis10.0
46malt lymphoma10.0
47nephrolithiasis10.0
48renal cell carcinoma10.0
49renal oncocytoma10.0
50ulcerative colitis10.0

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Symptoms for Colon Adenocarcinoma

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Drugs & Therapeutics for Colon Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

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Anatomical Context for Colon Adenocarcinoma

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MalaCards organs/tissues related to Colon Adenocarcinoma:

32
Colon, Liver, Lung, Lymph node, Thyroid, T cells, Prostate, Endothelial, Bone, Breast, Myeloid, B cells, Smooth muscle, Nk cells, Pituitary

Animal Models for Colon Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Colon Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3MUC2, ACSL4, HPSE, NPR1, NPPC, CDX1
2MP:00053877.7NQO1, UNG, MUC2, S100A4, NPR1, AREG
3MP:00028737.7UNG, ODC1, ACSL4, CALB2, S100A4, CDX1
4MP:00053977.5CDX1, FUT4, NQO1, UNG, MUC2, ACSL4

Publications for Colon Adenocarcinoma

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Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 667)
idTitleAuthorsYear
1
TNFI+ gene/protein in tumorigenesis of sporadic colon adenocarcinoma. (25102301)
2014
2
Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. (25051885)
2014
3
VEGF-C and VEGF-D overexpression is more common in left-sided and well-differentiated colon adenocarcinoma. (24173916)
2014
4
Distant ureteral metastasis from colon adenocarcinoma: report of a case and review of the literature. (24716082)
2014
5
Size- and dose-dependent toxicity of cellulose nanocrystals (CNC) on human fibroblasts and colon adenocarcinoma. (24856254)
2014
6
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
7
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor I^. (23339868)
2013
8
Paraneoplastic optic neuropathy and retinopathy associated with colon adenocarcinoma. (24093201)
2013
9
Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2. (23582141)
2013
10
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1I+,25-dihydroxyvitamin Da88 function in human colon adenocarcinoma LS180 cells. (22562045)
2012
11
Atypical presentation of colon adenocarcinoma: a case report. (22330123)
2012
12
Facial cutaneous metastasis of colon adenocarcinoma. (23089416)
2012
13
Progressive multiple cranial nerve palsies as the presenting symptom of meningeal carcinomatosis from occult colon adenocarcinoma. (22466842)
2012
14
Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. (21789651)
2011
15
Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. (21779837)
2011
16
Apple procyanidins activate apoptotic signaling pathway in human colon adenocarcinoma cells by a lipid-raft independent mechanism. (19666002)
2009
17
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. (19253370)
2009
18
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. (19470241)
2009
19
Activation of Notch signaling in human colon adenocarcinoma. (19020755)
2008
20
Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). (18507053)
2008
21
Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. (18541341)
2008
22
A novel dendritic cell-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model. (17275030)
2007
23
Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. (17971901)
2007
24
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. (17083937)
2006
25
Human Flt3 ligand from Pichia pastoris inhibits growth of lymphoma and colon adenocarcinoma in mice. (16528967)
2006
26
Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. (15546874)
2005
27
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
28
Functional expression of TWEAK in human colonic adenocarcinoma cells. (15586228)
2005
29
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma. (15613481)
2005
30
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. (15309463)
2005
31
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. (14578160)
2004
32
Marked survival prolongation of mice bearing a transplantable colon adenocarcinoma by treatment with radioactive platinum-[125I]histamine complex. Preliminary report. (15968596)
2004
33
Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: optical and ultrastructural study in the rat. (14654918)
2004
34
Assembly and functional analysis of tight junction in a colon adenocarcinoma cell line: effect of glucose depletion. (12839342)
2003
35
Ribonucleotide reductase subunit one as gene therapy target: commentary re: M-Y. Cao et al., Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma. Clin. Cancer Res., 9: 4304-4308, 2003. (14555499)
2003
36
Liver transplantation for metastatic colon adenocarcinoma: report of a case with 10 years of follow-up without recurrence. (12802483)
2003
37
Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cells. (12590703)
2002
38
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. (12240936)
2002
39
Photodynamic effects of mTHPC on human colon adenocarcinoma cells: photocytotoxicity, subcellular localization and apoptosis. (12003131)
2002
40
Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line. (11921276)
2002
41
Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. (11478796)
2001
42
Activation of K-ras and c-erbB-2 protooncogenes in human colonic adenocarcinomas]. (11471321)
2001
43
Dissemination of latent colon adenocarcinoma after laparoscopic cholecystectomy. (10604625)
1999
44
Functional heterogeneity of colonic adenocarcinoma mucins for inhibition of Entamoeba histolytica adherence to target cells. (9561779)
1998
45
Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. (9002470)
1997
46
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. (8549662)
1996
47
Characterization of tumorigenic sub-lines from a poorly tumorigenic human colon-adenocarcinoma cell line. (8782656)
1996
48
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29. (7695773)
1995
49
Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line. (1378304)
1992
50
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. (2032228)
1991

Variations for Colon Adenocarcinoma

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Expression for genes affiliated with Colon Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

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Pathways related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0NQO1, UGT1A6
2
Show member pathways
AhR pathway37
10.0NQO1, UGT1A6
3
Show member pathways
10.0NQO1, UGT1A6
4
Show member pathways
8.3HPSE, UGT1A6, FUT4, NQO1, TNFRSF6B, ODC1

Compounds for genes affiliated with Colon Adenocarcinoma

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Compounds related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1urodilatin4410.3NPR1, NPPC
2dicoumarol4410.3ODC1, NQO1
38-bromo cgmp4410.3NPPC, NPR1
4ng-nitro-l-arginine4410.3ODC1, NPPC
5cobalamin44 2411.2TCN2, ODC1
6beta-naphthoflavone44 1111.1UGT1A6, NQO1
7uridine44 24 1112.1ODC1, UNG, UGT1A6
8thymidylate4410.0NQO1, UNG, ODC1
9gamma-glutamylcysteine44 24 1112.0ODC1, NQO1
10agarose449.9UNG, MUC2, HPSE
11carbohydrates449.8FUT4, ODC1, MUC2
12trifluoperazine44 28 50 1112.8UGT1A6, ODC1, S100A4
13glyceraldehyde 3-phosphate449.8UNG, ODC1, HPSE
14isoproterenol44 1110.8AREG, NPPC, ODC1
15folate449.7NQO1, UNG, ODC1, TCN2
16creatinine449.7NQO1, TCN2, HPSE, NPPC
17prostaglandin449.7AREG, NPPC, ODC1
18methotrexate50 44 1111.7MUC2, ODC1, NQO1
19dmso449.7UGT1A6, MUC2, LGALS4
20galactose449.6LGALS4, MUC2, FUT4
21chloramphenicol44 2 50 1112.6NQO1, ODC1, TCN2, LGALS4
225-aza-2deoxycytidine449.5MUC2, HPSE, S100A4, CDX1
235fluorouracil449.5NQO1, UNG, MUC2
24heparin44 28 24 1112.5ODC1, HPSE, NPPC, AREG
25forskolin44 50 1111.5AREG, NPPC, NPR1, MUC2
26flutamide44 61 1111.4ODC1, AREG
27nacl449.4UNG, HPSE, S100A4
28cycloheximide449.2NQO1, UNG, ODC1, TCN2, AREG
29polysaccharide449.1AREG, HPSE, LGALS4, FUT4
30cysteine449.1NQO1, ODC1, MUC2, LGALS4, NPR1, NPPC
31nitric oxide44 24 1111.0ODC1, HPSE, CALB2, NPR1, NPPC
32glutamate448.9UNG, ODC1, HPSE, CALB2, NPR1
33oligonucleotide448.8UNG, MUC2, HPSE, S100A4, AREG
34thymidine44 249.2UNG, ODC1, LGALS4, CALB2, NPPC, AREG
35testosterone44 61 24 1111.1UGT1A6, NQO1, ODC1, LGALS4, CALB2, NPPC
36progesterone44 28 61 24 1112.1MUC2, LGALS4, CALB2, S100A4, AREG
37serine448.0NQO1, UNG, ODC1, MUC2, LGALS4, HPSE
38steroid447.9LGALS4, ACSL4, HPSE, CALB2, S100A4, AREG
39tyrosine447.7ODC1, LGALS4, CALB2, S100A4, NPPC, AREG
40retinoic acid44 248.6UGT1A6, FUT4, ODC1, MUC2, LGALS4, S100A4
41calcium44 50 24 1110.5MUC2, LGALS4, HPSE, CALB2, S100A4, NPPC
42estrogen447.1AREG, NQO1, ODC1, MUC2, LGALS4, HPSE

GO Terms for genes affiliated with Colon Adenocarcinoma

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Biological processes related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0NPPC, NPR1
2positive regulation of cGMP biosynthetic processGO:03082810.0NPPC, NPR1
3receptor guanylyl cyclase signaling pathwayGO:0071689.9NPPC, NPR1
4regulation of blood vessel sizeGO:0508809.7NPR1, NPPC
5small molecule metabolic processGO:0442818.9HPSE, ACSL4, TCN2, ODC1, NQO1, UGT1A6

Products for genes affiliated with Colon Adenocarcinoma

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Sources for Colon Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet