MCID: CLN015
MIFTS: 48

Colon Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Colon Adenocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

MalaCards: Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to adenocarcinoma and colon cancer. An important gene associated with Colon Adenocarcinoma is RPS3 (ribosomal protein S3). The compounds progesterone and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and liver.

Aliases & Classifications for Colon Adenocarcinoma

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon adenocarcinoma 8 44
adenocarcinoma of colon 8 60
colonic adenocarcinoma 8


External Ids:

Disease Ontology8 DOID:234
SNOMED-CT56 255082000
NCIt39 C4349

Related Diseases for Colon Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0CEACAM5, CALB2, VIP, RPS3, S100A4, TNFRSF6B
2colon cancer30.9HPSE, CDX1, MUC2, TYMS, AREG, TNFRSF6B
3lung adenocarcinoma30.7CEACAM5, CEACAM7, KRT20, S100A4, CALB2
4leukemia30.6FUT4, EIF4E, HPSE, TYMS, AREG, RPS3
5gastric adenocarcinoma30.5VIP, S100A4, TYMS, MUC2, KRT20, CEACAM7
6melanoma30.4CALB2, S100A4, AREG, HPSE, EIF4E, CEACAM7
7adenoma30.4CEACAM5, CEACAM7, ACSL4, KRT20, SI, EIF4E
8hepatocellular carcinoma30.3VIP, TNFRSF6B, AREG, MUC2, HPSE, ACSL4
9cholangiocarcinoma30.3MUC2, EIF4E, KRT20, CEACAM5
10signet ring cell adenocarcinoma30.3MUC2, KRT20, CEACAM5
11squamous cell carcinoma30.1CALB2, S100A4, AREG, TYMS, MUC2, CDX1
12cervical adenocarcinoma30.1CALB2, KRT20, CEACAM7, CEACAM5
13stomach cancer29.9CDX1, MUC2, TYMS, AREG, TNFRSF6B, S100A4
14breast cancer29.9VIP, S100A4, AREG, TYMS, MUC2, HPSE
15herpes simplex29.9LGALS4, TNFRSF6B
16endometriosis29.9CALB2
17colonic disease10.4
18mucinous adenocarcinoma10.4
19colon mucinous adenocarcinoma10.4
20colon lymphoma10.2
21thyroiditis10.2
22submucosal invasive colon adenocarcinoma10.2
23adenocarcinoma in situ10.2
24laryngitis10.2
25crohn's disease10.1
26neuroendocrine carcinoma10.1
27colon squamous cell carcinoma10.1
28chronic myeloid leukemia10.1
29imperforate anus10.1
30colon signet ring adenocarcinoma10.1
31peutz-jeghers syndrome10.1
32anus adenocarcinoma10.1
33breast adenocarcinoma10.1
34cervicitis10.1
35chronic lymphocytic leukemia10.1
36hepatitis10.1
37myeloid leukemia10.1
38peritonitis10.1
39prostate adenocarcinoma10.1
40prostatitis10.1
41rhabdomyosarcoma10.1
42vaginitis10.1
43cushing's syndrome10.0
44muir-torre syndrome10.0
45pelger-huet anomaly10.0
46sebaceous adenocarcinoma10.0
47apocrine adenocarcinoma10.0
48rectum adenocarcinoma10.0
49colorectal cancer10.0S100A4, AREG, TYMS, MUC2, CDX1, SI
50non-small cell lung carcinoma10.0S100A4, AREG, TYMS, MUC2, HPSE, CEACAM7

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to colon adenocarcinoma

Clinical Features for Colon Adenocarcinoma

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Drugs & Therapeutics for Colon Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colon Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Colon Adenocarcinoma

Search NIH Clinical Center for Colon Adenocarcinoma

Search CenterWatch for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

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Anatomical Context for Colon Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Colon Adenocarcinoma:

32
Colon, Appendix, Liver, Lung, Lymph node, Breast, Prostate, Thyroid, T cells, Endothelial, Pancreas, Myeloid, B cells, Bone, Ovary, Smooth muscle, Pituitary, Cervix, Nk cells

Animal Models for Colon Adenocarcinoma or affiliated genes

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Publications for Colon Adenocarcinoma

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50PubMed
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Articles related to Colon Adenocarcinoma:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. (24418929)
2014
2
Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma. (22048948)
2012
3
Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells. (22363234)
2012
4
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells. (23099482)
2012
5
Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells. (22552326)
2012
6
Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells. (21402757)
2011
7
Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis. (21338095)
2011
8
Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma. (21079973)
2011
9
Adenocarcinoma of colon presenting as Cushing's syndrome. (20026802)
2010
10
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. (19253370)
2009
11
Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. (19737943)
2009
12
Occurrence of colon adenocarcinoma in chronic myeloid leukemia patients treated with imatinib: report of two cases and review of the literature. (18452989)
2009
13
Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas. (19581844)
2009
14
Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis. (19353842)
2009
15
Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). (18507053)
2008
16
Ascending colon adenocarcinoma with tonsillar metastasis: a case report and review of the literature. (19084924)
2008
17
Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses. (18413313)
2008
18
Galanin is up-regulated in colon adenocarcinoma. (18006926)
2007
19
Visualization of astaxanthin localization in HT29 human colon adenocarcinoma cells by combined confocal resonance Raman and fluorescence microspectroscopy. (17039456)
2006
20
Functional expression of TWEAK in human colonic adenocarcinoma cells. (15586228)
2005
21
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon. (15797632)
2005
22
Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: optical and ultrastructural study in the rat. (14654918)
2004
23
Invasive adenocarcinoma arising from uterine adenomyosis involving the rectosigmoid colon. (15361215)
2004
24
E2F-1 transcription factor immunoexpression is inversely associated with tumor growth in colon adenocarcinomas. (15517914)
2004
25
Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas. (12925308)
2003
26
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. (14662896)
2003
27
Actin in human colon adenocarcinoma cells with different metastatic potential. (12545189)
2002
28
Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. (12196919)
2002
29
Inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides. (11764005)
2001
30
Elevated expression of caveolin-1 in adenocarcinoma of the colon. (11345836)
2001
31
Calretinin and calretinin-22k increase resistance toward sodium butyrate-induced differentiation in CaCo-2 colon adenocarcinoma cells. (11461122)
2001
32
Mucinous adenocarcinoma arising in a neovagina using the sigmoid colon thirty years after operation: a case report. (11344485)
2001
33
Soybean saponins inhibit cell proliferation by suppressing PKC activation and induce differentiation of HT-29 human colon adenocarcinoma cells. (11588895)
2001
34
Ecto-5'-nucleotidase from a human colon adenocarcinoma cell line. Correlation between enzyme activity and levels in intact cells. (9788749)
1998
35
Isolation, purification, and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells. (9614124)
1998
36
Expression of Fas ligand in liver metastases of human colonic adenocarcinomas. (9177233)
1997
37
Human recombinant interferon alpha-2a plus 3'-azido-3'-deoxythymidine. Synergistic growth inhibition with evidence of impaired DNA repair in human colon adenocarcinoma cells. (9105409)
1997
38
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells. (9815750)
1997
39
Musculoskeletal case of the day. Metastatic carcinomatous arthritis from mucinous adenocarcinoma of the colon. (9297373)
1997
40
Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells. (8913270)
1996
41
High zinc concentrations in culture media affect copper uptake and transport in differentiated human colon adenocarcinoma cells. (8648446)
1996
42
Differential expression of complement proteins and regulatory decay accelerating factor in relation to differentiation of cultured human colon adenocarcinoma cell lines. (8801206)
1996
43
Angiodysplasia of the colon mimicking adenocarcinoma. (8456694)
1993
44
Transforming growth factor-beta 1 induces transforming growth factor- alpha promoter activity and transforming growth factor-alpha secretion in the human colon adenocarcinoma cell line FET. (8358733)
1993
45
Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies. (1371500)
1992
46
Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. (1850957)
1991
47
Ultrasound case of the day. Poorly differentiated mucinous adenocarcinoma of the sigmoid colon, metastatic to the tunica vaginalis of the left hemiscrotum. (2543040)
1989
48
A case of nontraumatic clostridial gas gangrene occurring in a patient with colon adenocarcinoma, liver cirrhosis, and diabetes mellitus. (3739709)
1986
49
Adenocarcinoma of the colon associated with benign appendiceal neoplasm. (7089665)
1982
50
Primary scirrhous adenocarcinoma of the colon (signet-ring cell type). (6274043)
1981

Genetic Variations for Colon Adenocarcinoma

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Expression for genes affiliated with Colon Adenocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for genes affiliated with Colon Adenocarcinoma

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Compounds for genes affiliated with Colon Adenocarcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Colon Adenocarcinoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.9CALB2, S100A4, AREG, MUC2, EIF4E, KRT20
2tyrosine4411.9VIP, CALB2, S100A4, AREG, EIF4E, SI
3calcium44 49 11 2414.8VIP, CALB2, S100A4, AREG, MUC2, HPSE
4thymidine44 2412.8VIP, CALB2, AREG, TYMS, SI, LGALS4
5retinoic acid44 2412.8S100A4, AREG, MUC2, CDX1, EIF4E, LGALS4
6polysaccharide4411.7AREG, TYMS, HPSE, SI, LGALS4, FUT4
7vegf4411.6VIP, AREG, TYMS, HPSE, EIF4E, KRT20
8cysteine4411.6VIP, TYMS, MUC2, EIF4E, SI, LGALS4
9steroid4411.4LGALS4, ACSL4, EIF4E, S100A4, CALB2
10paraffin4411.4CEACAM5, KRT20, SI, MUC2, CALB2
11mucicarmine4411.3CALB2, KRT20, CEACAM7, CEACAM5
12glucose4411.3MUC2, HPSE, EIF4E, SI, LGALS4, CEACAM5
13b 7234411.3CALB2, KRT20, CEACAM7, CEACAM5
14hematoxylin4411.3CALB2, MUC2, KRT20, CEACAM5
15gefitinib44 49 1113.3AREG, TYMS, CEACAM7, CEACAM5
16carbohydrates4411.3MUC2, SI, FUT4, CEACAM5
175-aza-2deoxycytidine4411.2S100A4, MUC2, CDX1, HPSE
18estrogen4411.2CEACAM7, SI, CALB2
19butyrate4411.2CEACAM7, SI, CALB2
205fluorouracil4411.2TYMS, MUC2, CEACAM7, CEACAM5
21serine4411.2VIP, AREG, TYMS, MUC2, HPSE, EIF4E
22crcs4411.2MUC2, CDX1, CEACAM5
23testosterone44 59 11 2414.1VIP, CALB2, AREG, KRT20, LGALS4
24lactose44 1112.1FUT4, LGALS4, SI
25triiodothyronine4411.0SI, LGALS4, CEACAM7
262,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL1111.0CEACAM5, EIF4E
27n-acetylglucosamine4411.0CEACAM5, FUT4, HPSE
285-fluorocytosine4410.9CEACAM5, TYMS
29actinomycin d4410.9CEACAM7, EIF4E, MUC2, AREG
30galactose4410.9FUT4, LGALS4, MUC2
315-deoxy-5-fluorouridine4410.9CEACAM5, TYMS
32mitomycin c4410.8CEACAM5, TYMS, AREG
33oligonucleotide4410.8S100A4, AREG, MUC2, HPSE, EIF4E

GO Terms for genes affiliated with Colon Adenocarcinoma

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Products for genes affiliated with Colon Adenocarcinoma

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Sources for Colon Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet