MCID: CLN016
MIFTS: 65

Colon Cancer malady

Cancer diseases, Gastrointestinal diseases categories
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Summaries for Colon Cancer

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Disease Ontology:8 A colorectal cancer that is located in the colon.

MalaCards based summary: Colon Cancer, also known as carcinoma of colon, is related to lynch syndrome and familial adenomatous polyposis. An important gene associated with Colon Cancer is PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), and among its related pathways are VEGFR3 signaling in lymphatic endothelium and Estrogen signaling pathway. The compounds mdi-a and n-methyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include the colon, colon and liver, and related mouse phenotypes are integument and tumorigenesis.

Description from OMIM:46 114500

Aliases & Classifications for Colon Cancer

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Colon Cancer, Aliases & Descriptions:

Name: Colon Cancer 8
Carcinoma of Colon 8 62
 
Colonic Carcinoma 8 62
Colon Carcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Colon Cancer

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Diseases in the Colon Cancer family:

Colon Carcinoma in Situ

Diseases related to Colon Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 295)
idRelated DiseaseScoreTop Affiliating Genes
1lynch syndrome31.7MSH2, MSH6, MLH1
2familial adenomatous polyposis31.4MSH2, MSH6, MLH1
3colorectal cancer31.3SRC, MSH2, MSH6, MLH1, PIK3CA
4adenoma31.1MLH1, MSH6, MSH2, SRC
5familial colorectal cancer31.0MLH1, MSH6, MSH2
6muir-torre syndrome30.9MSH2, MSH6, MLH1
7turcot syndrome30.7MSH6, MLH1
8neurofibromatosis30.7MLH1, MSH6, MSH2
9adenocarcinoma30.6PIK3CA, MLH1, AKT1, MSH6, MSH2, SRC
10ovarian cancer30.5PIK3CA, MLH1, MSH6, MSH2
11colonic benign neoplasm30.1PIK3CA, MLH1, AKT1, MSH6, MSH2, SRC
12melanoma30.1PIK3CA, MLH1, AKT1, MSH2, SRC
13breast cancer30.1PIK3CA, MLH1, AKT1, MSH6, MSH2, SRC
14glioblastoma30.0SRC, AKT1, MLH1, PIK3CA
15astrocytoma30.0PIK3CA, MLH1, AKT1, MSH2
16pancreatic cancer30.0PIK3CA, MLH1, AKT1, MSH2, SRC
17stomach cancer30.0MSH2, MSH6, AKT1, MLH1, PIK3CA
18endometrial carcinoma29.8MSH2, MSH6, AKT1, MLH1, PIK3CA
19endotheliitis10.8
20hypoxia10.6
21transverse colon cancer10.6
22colitis10.6
23ascending colon cancer10.6
24small intestine cancer10.6MLH1, MSH6
25hepatitis10.6
26rectal neoplasm10.5MLH1, MSH6, MSH2
27skin benign neoplasm10.5MSH2, MSH6, MLH1
28keratoacanthoma10.5MLH1, MSH2
29hematologic cancer10.5MSH2, MSH6, MLH1
30descending colon cancer10.4
31inflammatory bowel disease10.4
32ulcerative colitis10.4
33colon adenocarcinoma10.4
34leukemia10.4
35obesity10.4
36peritonitis10.3
37prostatitis10.3
38colon adenoma10.3
39diverticulitis10.3
40pancreatitis10.3
41thyroiditis10.3
42tetraploidy10.3
43ataxia telangiectasia10.2
44gastric cancer10.2
45hepatocellular carcinoma10.2
46splenic abscess10.2
47cronkhite-canada syndrome10.2
48situs inversus10.2
49thyroid lymphoma10.2
50intussusception10.2

Graphical network of the top 20 diseases related to Colon Cancer:



Diseases related to colon cancer

Symptoms for Colon Cancer

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Clinical features from OMIM:

114500

Drugs & Therapeutics for Colon Cancer

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Drug clinical trials:

Search ClinicalTrials for Colon Cancer

Search NIH Clinical Center for Colon Cancer

Genetic Tests for Colon Cancer

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Anatomical Context for Colon Cancer

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MalaCards organs/tissues related to Colon Cancer:

32
Colon, Liver, Endothelial, Breast, Lymph node, T cells, Lung, Testes, Bone, Prostate, Neutrophil, Bone marrow, Thyroid, Monocytes, Kidney, Testis, Myeloid, Pancreas, Ovary, B cells, Pituitary, Whole blood, Cortex, Small intestine, Skin, Cervix, Nk cells

FMA organs/tissues related to Colon Cancer:

14
The colon

Animal Models for Colon Cancer or affiliated genes

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MGI Mouse Phenotypes related to Colon Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.1MLH1, AKT1, MSH6, MSH2, SRC, PIK3CA
2MP:000200610.0SRC, PIK3CA, MLH1, AKT1, MSH6, MSH2
3MP:00107689.6PIK3CA, MLH1, SDCCAG8, TSHZ1, AKT1, MSH6

Publications for Colon Cancer

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Articles related to Colon Cancer:

(show top 50)    (show all 3944)
idTitleAuthorsYear
1
The Disparate Twins: A Comparative Study of CXCR4 and CXCR7 in SDF-1I+-Induced Gene Expression, Invasion and Chemosensitivity of Colon Cancer. (24255072)
2014
2
Hypoxia triggers a Nur77-I^-catenin feed-forward loop to promote the invasive growth of colon cancer cells. (24423919)
2014
3
Metachronous adenoma on ileorectal anastomosis suture line and submucosal deep invasive cancer suspected of rapid growth in rectal remnant following long-term interval after curative surgery for advanced colon cancer. (23617649)
2013
4
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry. (23745025)
2013
5
Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. (24055891)
2013
6
Epigenetic and genetic features of 24 colon cancer cell lines. (24042735)
2013
7
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. (22842502)
2013
8
Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells. (23733421)
2013
9
Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis. (23649548)
2013
10
Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. (22120717)
2012
11
The matrix metalloproteinase-7 regulates the extracellular shedding of syndecan-2 from colon cancer cells. (22227189)
2012
12
CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. (22871210)
2012
13
Effect of sodium butyrate on apoptosis and stromal interaction molecule and Orai1 activity in human colon cancer HCT-116 cells in vitro]. (22381755)
2012
14
STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. (21900397)
2011
15
RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer. (19686745)
2010
16
Post-translational modulation of CD133 expression during sodium butyrate-induced differentiation of HT29 human colon cancer cells: implications for its detection. (20333645)
2010
17
Colon cancer stem cells: promise of targeted therapy. (20420952)
2010
18
The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression. (20138990)
2010
19
Effects of epigallocatechin-3-gallate on the proliferation of colonic cancer cell line SW620 and PAK1 gene expression]. (19726294)
2009
20
IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis. (19204921)
2009
21
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. (20046424)
2009
22
Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells. (18729103)
2009
23
Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms. (20011542)
2009
24
Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib. (18497962)
2008
25
Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. (18767036)
2008
26
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. (18299982)
2008
27
Effects of hFRNK on E-cadherin/beta-catenin in colon cancer cells in vitro]. (17892129)
2007
28
Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis. (17191116)
2007
29
MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. (17513868)
2007
30
Increased VEGF165 expression in HCT116 colon cancer cells after transient transfection with a GFP vector encoding HIF-1 gene. (18365547)
2007
31
A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients. (17390049)
2007
32
Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. (16928828)
2006
33
Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancer. (16773190)
2006
34
Effects of expression of thymidine phosphorylase induced by gamma-interferon on regulation of antineoplastic activity of fluorouracil on colonic cancer]. (15949342)
2005
35
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. (16110022)
2005
36
Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. (16308138)
2005
37
Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites. (15548677)
2004
38
Immunohistochemical detection of the hMLH1 and hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer. (15254659)
2004
39
Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. (14679305)
2004
40
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. (14527959)
2003
41
Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. (12706680)
2003
42
Adjuvant effect of a Flt3 ligand (FL) gene-transduced xenogeneic cell line in a murine colon cancer model. (12443727)
2002
43
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. (11950812)
2002
44
Single alteration of p53 or E-cadherin genes can alter the surgical resection benefit in an experimental model of colon cancer. (11535849)
2001
45
Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. (10804085)
2000
46
Meat consumption, genetic susceptibility, and colon cancer risk: a United States multicenter case-control study. (9950235)
1999
47
Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer. (10403737)
1999
48
Growth inhibitory effects of 1,25-dihydroxyvitamin D3 and its synthetic analogue, 1alpha,25-dihydroxy-16-ene-23yne-26,27-hexafluoro-19-nor-cholecalcifero l (Ro 25-6760), on a human colon cancer xenograft. (9829754)
1998
49
Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. (8538189)
1995
50
Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3. (8033137)
1994

Variations for Colon Cancer

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Clinvar genetic disease variations for Colon Cancer:

6
id Gene Name Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
3AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551

Expression for genes affiliated with Colon Cancer

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Expression patterns in normal tissues for genes affiliated with Colon Cancer

Search GEO for disease gene expression data for Colon Cancer.

Pathways for genes affiliated with Colon Cancer

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Pathways related to Colon Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.4AKT1, PIK3CA
210.4AKT1, PIK3CA
310.4AKT1, PIK3CA
410.3SRC, PIK3CA
510.3SRC, PIK3CA
6
Show member pathways
10.3SRC, AKT1, PIK3CA
7
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.3PIK3CA, AKT1, SRC
810.3SRC, AKT1, PIK3CA
9
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
10.3SRC, AKT1, PIK3CA
10
Show member pathways
Development Flt3 signaling60
10.3PIK3CA, AKT1, SRC
1110.3PIK3CA, AKT1, SRC
12
Show member pathways
IFN-gamma pathway37
10.3PIK3CA, AKT1, SRC
1310.3SRC, AKT1, PIK3CA
1410.3PIK3CA, AKT1, SRC
15
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
10.3PIK3CA, AKT1, SRC
16
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
10.3SRC, AKT1, PIK3CA
17
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.3PIK3CA, AKT1, SRC
18
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
10.3SRC, AKT1, PIK3CA
19
Show member pathways
10.3SRC, AKT1, PIK3CA
2010.3PIK3CA, AKT1, SRC
21
Show member pathways
10.3PIK3CA, AKT1, SRC
22
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.3SRC, AKT1, PIK3CA
23
Show member pathways
10.3PIK3CA, AKT1, SRC
24
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
10.3PIK3CA, AKT1, SRC
25
Show member pathways
VEGFR1 specific signals37
10.3SRC, AKT1, PIK3CA
2610.3SRC, AKT1, PIK3CA
2710.3PIK3CA, AKT1, SRC
28
Show member pathways
TRAIL signaling pathway37
10.3PIK3CA, AKT1, SRC
2910.3SRC, AKT1, PIK3CA
3010.3PIK3CA, AKT1, SRC
3110.3SRC, AKT1, PIK3CA
3210.3SRC, AKT1, PIK3CA
33
Show member pathways
Angiogenesis37
10.3PIK3CA, AKT1, SRC
3410.3PIK3CA, AKT1, SRC
3510.3PIK3CA, AKT1, SRC
3610.3PIK3CA, AKT1, SRC
3710.3SRC, AKT1, PIK3CA
38
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
10.3PIK3CA, AKT1, SRC
3910.3SRC, AKT1, PIK3CA
4010.3PIK3CA, AKT1, SRC
4110.3PIK3CA, AKT1, SRC
4210.3AKT1, MSH6, MSH2
43
Show member pathways
10.3MLH1, MSH6, MSH2
4410.3MSH2, MSH6, MLH1
45
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.2MSH2, MSH6, AKT1, PIK3CA
46
Show member pathways
Signaling Pathways in Glioblastoma37
10.2PIK3CA, AKT1, MSH6, SRC
47
Show member pathways
10.2MLH1, MSH6, MSH2, UVRAG
4810.2PIK3CA, MLH1, AKT1, MSH6, MSH2
4910.1MLH1, AKT1, MSH6, MSH2, SRC
50
Show member pathways
Signal transduction PTEN pathway60
10.1SRC, MSH2, MSH6, AKT1, MLH1, PIK3CA

Compounds for genes affiliated with Colon Cancer

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Compounds related to Colon Cancer according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1mdi-a4410.7SRC, AKT1
2n-methyl-n-nitrosourea4410.6MLH1, MSH6, MSH2
3mononucleotide4410.6MLH1, MSH6, MSH2
4o6-methylguanine4410.6MSH2, MSH6, MLH1
5ag 10244410.6SRC, AKT1
6ag 14784410.6PIK3CA, AKT1, SRC
7gefitinib44 50 1112.6SRC, AKT1, PIK3CA
8crcs4410.6MSH2, MSH6, MLH1, PIK3CA
9carboplatin44 50 1112.6MLH1, AKT1, MSH2
105fluorouracil4410.6PIK3CA, MLH1, MSH2, SRC
11gemcitabine44 50 1112.5MLH1, AKT1, SRC
12biotin44 24 1112.5MSH2, MSH6, MLH1
136 thioguanine4410.5MSH2, MLH1
14paclitaxel44 50 1112.5SRC, AKT1, MLH1, PIK3CA
15phosphatidylinositol-3,4,5-trisphosphate44 2411.5PIK3CA, AKT1, SRC
16everolimus44 50 1112.5PIK3CA, AKT1
17paraffin4410.5MLH1, AKT1, MSH6, MSH2
18doxorubicin44 50 1112.4PIK3CA, MLH1, AKT1, MSH6, MSH2, SRC
19cisplatin44 50 61 1113.4SRC, MSH2, MSH6, AKT1, MLH1, PIK3CA
20inositol4410.4SRC, AKT1, PIK3CA
21ptdins(3)p4410.4PIK3CA, AKT1
22threonine4410.4SRC, MSH6, AKT1, MLH1, PIK3CA
23mnng4410.4MSH2, MLH1
24arsenite44 2411.3SRC, AKT1, PIK3CA
25temozolomide44 1111.3MLH1, MSH2
26staurosporin4410.0PIK3CA, SRC

GO Terms for genes affiliated with Colon Cancer

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Cellular components related to Colon Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromosomeGO:00022810.3MSH2, MSH6
2MutSalpha complexGO:03230110.0MSH2, MSH6

Biological processes related to Colon Cancer according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1somatic hypermutation of immunoglobulin genesGO:01644610.6MSH2, MSH6, MLH1
2meiotic mismatch repairGO:00071010.6MSH2, MSH6
3isotype switchingGO:04519010.6MLH1, MSH6, MSH2
4mismatch repairGO:00629810.5MSH2, MSH6, MLH1
5maintenance of DNA repeat elementsGO:04357010.5MSH6, MSH2
6somatic recombination of immunoglobulin gene segmentsGO:01644710.5MSH6, MSH2
7reciprocal meiotic recombinationGO:00713110.5MLH1, MSH6, RAD54B
8positive regulation of helicase activityGO:05109610.5MSH2, MSH6
9ATP catabolic processGO:00620010.4RAD54B, MSH2, MSH6, MLH1
10negative regulation of DNA recombinationGO:04591010.4MSH2, MSH6
11T cell costimulationGO:03129510.4PIK3CA, AKT1, SRC
12determination of adult lifespanGO:00834010.3MSH6, MSH2
13fibroblast growth factor receptor signaling pathwayGO:00854310.3SRC, AKT1, PIK3CA
14negative regulation of anoikisGO:200081110.2SRC, PIK3CA
15oogenesisGO:04847710.0SRC, MLH1

Molecular functions related to Colon Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1single thymine insertion bindingGO:03214310.6MSH2, MSH6
2oxidized purine DNA bindingGO:03235710.5MSH6, MSH2
3guanine/thymine mispair bindingGO:03213710.5MSH2, MSH6, MLH1
4single guanine insertion bindingGO:03214210.5MSH6, MSH2
5kinase activityGO:01630110.5PIK3CA, AKT1, SRC
6MutLalpha complex bindingGO:03240510.4MSH2, MSH6
7four-way junction DNA bindingGO:00040010.3MSH2, MSH6
8ADP bindingGO:04353110.3MSH2, MSH6
9mismatched DNA bindingGO:03098310.2MSH6, MSH2
10ATP bindingGO:00552410.1PIK3CA, MLH1, AKT1, MSH6, MSH2, SRC
11ATPase activityGO:01688710.0MSH2, MSH6, MLH1
12protein bindingGO:0055159.7PIK3CA, MLH1, USHBP1, SDCCAG8, UTP14A, AKT1

Products for genes affiliated with Colon Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Colon Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet