Colon Cancer malady

Wikipedia: Colorectal cancer, commonly known as colon cancer or bowel cancer, is a cancer from uncontrolled cell...⁴⁴ more...

MalaCards: Colon Cancer, also known as colon carcinoma, is related to carcinoma and prostatitis. An important gene associated with Colon Cancer is MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)), and among its related pathways are Metabolic pathways and ERK Signaling. The compounds dexamethasone and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are behavior/neurological and embryogenesis.

OMIM: 114500

Aliases & Descriptions:

colon cancer 6 7 33 8 32 colon carcinoma 43

Disease types for colon cancer family:

colon cancer (apc i1307k related)

Diseases related to colon cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 801)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	232.6	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIM3, PIAS1
2	prostatitis	193.8	PIK3CB, PIAS2, PIK3CA, PIK3R3, PIK3R1, PIAS1
3	pancreatitis	181.7	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIM3, PIK3CG
4	adenocarcinoma	181.4	PIK3CB, PIK3CA, PIK3R1, PIM3, PIK3CG, KLF4
5	leukemia	178.3	PIK3CB, PIAS2, PIK3CA, PIK3R3, PIK3R1, PIAS1
6	gastric cancer	161.4	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF4
7	melanoma	156.0	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, KLF5
8	hepatocellular carcinoma	155.7	PIK3CB, PIK3CA, PIK3R1, PIM3, PIK3CG, KLF6
9	esophagitis	140.8	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, KLF6
10	thyroiditis	136.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, RFC1
11	cervicitis	130.5	PIK3CA, PIK3CG, RFC1, PDCD4, PDE4A, RECK
12	hypoxia	127.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, RGCC
13	colon carcinoma	126.2	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF4
14	adenoma	126.0	PIK3CA, PIM3, KLF4, NCAM1, NCOR2, PDCD4
15	neuroblastoma	122.0	PIK3CB, PIAS2, PIK3CA, PIK3R1, PIK3CG, KLF4
16	ovarian carcinoma	119.8	PIK3CA, PIK3CG, PDCD4, RECK, RELA, PCNA
17	sarcoma	109.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCAM1, PDE4A
18	neuronitis	103.9	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, LRP6
19	myeloma	101.3	PIK3CA, PIK3R1, PIK3CG, LRP6, NCAM1, NCOR2
20	fibrosis	100.4	PIK3CA, PIK3CG, KLF6, PDE4A, RECK, RELA
21	cholesterol	98.1	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, LRP6
22	osteosarcoma	94.3	PIK3CB, PIK3CA, PIK3CG, RFC1, PDE4A, RECK
23	astrocytoma	92.0	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
24	atherosclerosis	88.6	PIK3CG, LRP6, KLF4, KLF5, PDE4A, RECK
25	retinoblastoma	84.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF6, RFC1
26	colon adenocarcinoma	83.9	KLF4, REG4, BUB1B, VIP, BSG, BRCA1
27	breast carcinoma	83.8	PIK3CA, PIK3R1, PIK3CG, RECK, CNR2, VWF
28	endometrial carcinoma	82.8	PIK3CB, PIK3CA, PIK3CG, NCOR2, RELA, CNR2
29	cholangiocarcinoma	80.6	PIK3CA, PIK3CG, LRRC26, NCAM1, PDCD4, RECK
30	polyposis	80.1	PIK3CG, KLF4, KLF6, REEP6, RELA, PCBD1
31	thyroid carcinoma	79.5	PIK3CA, PIK3CG, SFN, PCNA, RB1, SELE
32	peritonitis	77.3	REG4, RELA, VWF, PCNA, GC, SELE
33	obesity	77.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOR2, RECK
34	lung carcinoma	71.7	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
35	arthritis	70.5	PIK3CG, KLF5, RFC1, PDE4A, RECK, RELA
36	gonococcal synovitis	67.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
37	myeloid leukemia	67.1	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, KLF5
38	anemia	66.6	NCAM1, RELA, VWF, PCNA, GCLC, RB1
39	insulin resistance	66.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, RETN
40	alzheimer's disease	65.9	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP6, KLF6
41	rheumatoid arthritis	65.7	PIK3CG, KLF5, RFC1, PDE4A, RECK, RELA
42	ataxia	65.1	PIK3CA, PIK3R1, PIK3CG, CNR2, VWF, PCNA
43	fibrosarcoma	63.6	PIK3CG, RECK, RB1, SETD2, SERPINB2, SERPINE1
44	cystic fibrosis	63.3	PIK3CG, PDE4A, RECK, VWF, PCNA, GCLC
45	herpes simplex	61.6	PIAS2, PIK3CA, PIK3CG, RECK, PCNA, GC
46	cervical cancer	61.5	PIK3CA, PIK3CG, RFC1, RELA, SFN, PCNA
47	familial adenomatous polyposis	61.1	KLF4, KLF6, PCNA, BTRC, RB1, SERPINE1
48	retinitis	58.9	PIK3CA, PIK3CG, KLF6, PDE4A, CNBP, CNR1
49	hepatitis b	58.7	PIK3CA, PIK3R1, PIK3CG, KLF6, RELA, RETN
50	cerebritis	56.3	PIK3R1, PIK3CG, LRP6, KLF4, KLF6, NCAM1

Clinical features from OMIM: 114500

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to colon cancer:

²²

MGI Mouse Phenotypes related to colon cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	47.6	PIK3CA, LRP6, KLF4, NCAM1, NCOR2, CNR1
2	embryogenesis phenotype	MP:0005380	41.4	PIK3CB, PIK3CA, LRP6, KLF5, KLF6, RECK
3	skeleton phenotype	MP:0005390	37.7	PIK3CG, LRP6, RECK, RELA, SGPL1, CNBP
4	renal/urinary system phenotype	MP:0005367	31.3	LRP6, PDCD4, SGPL1, PCBD1, PCSK5, GCNT3
5	no phenotypic analysis	MP:0003012	24.5	PIK3R1, LRP6, CNR1, PCNA, PCSK5, RB1
6	limbs/digits/tail phenotype	MP:0005371	24.4	LRP6, RECK, RELA, SFN, PCSK5, RB1
7	adipose tissue phenotype	MP:0005375	23.8	PIK3CA, PIK3R1, LRP6, NCOR2, RETN, CNR1
8	endocrine/exocrine gland phenotype	MP:0005379	23.7	KLF4, KLF5, PDCD4, SGPL1, SFN, RBL2
9	liver/biliary system phenotype	MP:0005370	23.1	LRP6, KLF6, NCOR2, RECK, RETN, SFN
10	hearing/vestibular/ear phenotype	MP:0005377	21.8	LRP6, SFN, RB1, VDR, LMNA, MYC
11	respiratory system phenotype	MP:0005388	18.2	LRP6, KLF5, SGPL1, PCSK5, SELL, SEMA3A
12	other phenotype	MP:0005395	18.1	RECK, CNR1, RARA, RARB, CLU, KDR
13	pigmentation phenotype	MP:0001186	17.2	PCBD1, RB1, BRAF, BRCA1, LMNA, MYC
14	integument phenotype	MP:0010771	INF	PIK3CG, LRP6, KLF4, KLF6, RECK, RELA
15	immune system phenotype	MP:0005387	INF	PIM3, PIAS1, KLF5, PDCD4, PDE4A, RETNLB
16	mortality/aging	MP:0010768	INF	PIK3CB, PIK3CA, PIAS1, LRP6, KLF4, KLF5
17	hematopoietic system phenotype	MP:0005397	INF	PIM3, KLF6, SGPL1, SFN, PCNA, BUB1B
18	digestive/alimentary phenotype	MP:0005381	INF	LRP6, KLF4, KLF5, NCOR2, RETNLB, SGPL1
19	cellular phenotype	MP:0005384	INF	PIK3CB, PIK3CA, PIK3R1, PIM3, PIK3CG, LRP6
20	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R1, PIK3CG, KLF5, RELA, SGPL1
21	vision/eye phenotype	MP:0005391	INF	PIK3CA, LRP6, NCAM1, RELA, CNBP, SFN
22	reproductive system phenotype	MP:0005389	INF	ZNF143, PIK3CA, LRP6, KLF4, KLF6, PDCD4
23	craniofacial phenotype	MP:0005382	INF	LRP6, KLF4, NCOR2, SGPL1, CNBP, PCSK5
24	nervous system phenotype	MP:0003631	INF	LRP6, PDE4A, RECK, RELA, CNBP, CNR1
25	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3R1, PIM3, PIAS1, PIK3CG
26	cardiovascular system phenotype	MP:0005385	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, KLF6
27	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP6, KLF4
28	tumorigenesis	MP:0002006	INF	PIK3CB, PIK3CA, PIK3R1, KLF4, PDCD4, SFN
29	normal phenotype	MP:0002873	INF	PIAS2, PIK3R1, PIM3, PIDD, LRP6, KLF4

Articles related to colon cancer:

(show top 50)    (show all 2722)

id	Title	Authors	Year	Affiliating Genes
1	microRNA-365, down-regulated in colon cancer, inhibit s cell cycle progression and promotes apoptosis of colon cancer cells by probab ly targeting Cyclin D1 and Bcl-2. (22072615)	Nie J.... Han W.	2012	BCL2, CCND1, MIR365A
2	Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1. (21569759)	Lee H.... Oh E.S.	2011	SDC2, SDCBP
3	BRAF and RAS oncogenes regulate Rho GTPase pathways t o mediate migration and invasion properties in human colon cancer cells: a comp arative study. (21943101)	Makrodouli E.... Pintzas A.	2011	HRAS, BRAF, KRAS
4	Fem1b, a proapoptotic protein, mediates proteasome in hibitor-induced apoptosis of human colon cancer cells. (19908242)	Subauste M.C.... Maher J.F.	2010	APAF1, FEM1B
5	Four-and-a-half LIM protein 2 promotes invasive poten tial and epithelial-mesenchymal transition in colon cancer. (20460358)	Zhang W.... Wong B.C.	2010	FHL2
6	Loss of Bcl-2 expression in colon cancer: a prognosti c factor for recurrence in stage II colon cancer. (19027288)	Poincloux L.... Monges G.	2009	BCL2
7	DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells. (19551406)	Xu S.B.... Zhang W.J.	2009	PTPN6, STAT6, SOCS1
8	Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo. (19308290)	van der Horst E.H.... Sato A.K.	2009	BMP2, CEACAM1, KLF6
9	Modulation of NRF2 and UGT1A expression by epigalloca techin-3-gallate in colon cancer cells and BALB/c mice. (19719968)	Zhang Z.M.... Li Y.Q.	2009	NFE2L2, UGT1A1, UGT1A
10	Role of lipoxins and resolvins as anti-inflammatory a nd proresolving mediators in colon cancer. (19601807)	Janakiram N.B.... Rao C.V.	2009	TNF, IL6, IL1B
11	Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. (18521906)	Cho S.J.... Song I.S.	2008	ANXA5
12	The prognostic importance of thymidylate gene polymorphism in colon cancer stage II. (18629514)	Dysager L.... Jakobsen A.	2008	TYMS
13	RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells. (18922976)	Doublier S.... Bosia A.	2008	RHOA, ABCC3
14	Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. (18025273)	Moser C.... Stoeltzing O.	2007	HSP90AA1
15	Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers. (16809422)	Uchiyama S.... Kataoka H.	2007	C19orf33
16	Increased expression of extracellular matrix metalloproteinase inducer through interaction between fibroblasts and colonic cancer cells (18307883)	Zhang Y.W.... Chen L.L.	2007	BSG
17	Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells. (17086209)	Ivanov I.... Ionov Y.	2007	UPF1, FXR1
18	Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management. (17604322)	Yamazaki K.... Moriwaki H.	2007	PPARG
19	Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. (16299030)	Akiyoshi T.... Katano M.	2006	APC, CTNNB1, GLI1
20	Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer. (16292518)	Deutscher N.... Rogler G.	2006	IL11, IL11RA
21	Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer. (16426443)	Kouraklis G.... Sioka C.	2006	RB1, CCND1
22	Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. (16568373)	Miyazaki K.... Matsuzaki Y.	2006	TYMS, DPYD, UMPS
23	MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. (16568094)	Leszczyniecka M.... Phillips P.E.	2006	MAP1A, METAP1D
24	5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. (15547111)	Schneider-Stock R.... Gali-Muhtasib H.	2005	DNMT3B, DNMT1, DNMT3A
25	Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. (15743787)	Kuniyasu H.... Ohmori H.	2005	HMGB1
26	Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. (15710986)	Birkenkamp-Demtroder K.... Orntoft T.F.	2005	KRT8
27	LPA2 receptor mediates mitogenic signals in human colon cancer cells. (15728708)	Yun C.C.... Shim H.	2005	LPAR2, LPAR1, SLC9A3R2
28	Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. (16061910)	Correale P.... Francini G.	2005	CSF2, CEACAM3
29	Low microsatellite instability is associated with poor prognosis in stage C colon cancer. (15800322)	Kohonen-Corish M.R.... Bokey E.L.	2005	MGMT
30	Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell. (15655297)	Nishibori M.... Takahashi H.K.	2005	F2R, EPRS, F2RL1
31	Immunohistochemical detection of the hMLH1 and hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer. (15254659)	PlevovA! P.... KolA!r Z.	2004	MLH1
32	Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. (15340260)	McGivern A.... Jass J.R.	2004	BRAF, CDKN2A, MGMT
33	Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. (15155747)	Jin Z.... El-Deiry W.S.	2004	TNFSF10, TNFRSF10A
34	Molecular epidemiology of colon cancer. (20396547)	Kim D.H.... Ahn Y.O.	2004	MTHFR
35	Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer. (15065603)	Yamada Y.... Kimata K.	2004	HAS1, HAS3
36	Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. (15308587)	Baek S.J.... Lee S.H.	2004	GDF15
37	Prognostic implications of hMLH1 and p53 immunohistochemical status in right-sided colon cancer. (15657659)	Smyth E.F.... Cawkwell L.	2004	TP53, MLH1
38	Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (15308583)	Goodman J.E.... Harris C.C.	2004	PTGS1, PTGS2, ALOX5
39	Prognostic significance and correlation with survival of bcl-2 and TGF-beta RII in colon cancer. (14714614)	Kouraklis G.... Karatzas G.	2003	TGFBR2, BCL2
40	Colon cancer-associated DNA mutations: marker selection for the detection of proximal colon cancer. (14639104)	Berger B.M.... Glickman J.	2003	APC
41	Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer. (11832452)	Hashida H.... Miyake M.	2002	ANPEP
42	Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. (12420218)	Hampton R.... Juhl H.	2002	CEACAM5, KRT20
43	Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo. (11577001)	Leng S.L.... Bach L.A.	2001	IGFBP3, IGF2
44	The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer. (11606497)	Samowitz W.S.... Slattery M.L.	2001	MSH2, MLH1
45	Effect of shear stress and a stable prostaglandin I2 analogue on adhesive interactions of colon cancer cells and endothelial cells. (10469043)	Yoshida N.... Kondo M.	1999	SELE
46	Short chain fatty acids inhibit human (SW1116) colon cancer cell invasion by reducing urokinase plasminogen activator activity and stimulating TIMP-1 and TIMP-2 activities, rather than via MMP modulation. (9695737)	Emenaker N.J.... Basson M.D.	1998	MMP3, PLAU, MMP9
47	Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. (9444956)	Mao W.... Yeatman T.J.	1997	SRC
48	Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. (8690195)	Konishi M.... Miyaki M.	1996	TGFBR2, MSH2, MLH1
49	Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts. (8201382)	Welt S.... Old L.J.	1994	FAP
50	Overexpression of glutathione S-transferase and eleva tion of thiol pools in a multidrug-resistant human colon cancer cell line. (1346333)	Chao C.C.... Lin-Chao S.	1992	ABCB1

Genes related to colon cancer according to GeneCards:

(show top 50)    (show all 1319)

id	Symbol	Description	Score	GeneCards Section Context
1	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.1	Publications, Transcripts, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
2	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.1	Publications, Transcripts, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
3	MACC1	metastasis associated in colon cancer 1	11.1	Publications, Transcripts, Aliases & Descriptions, Proteins (show all 6 sections) Orthologs, Summaries
4	TSHZ1	teashirt zinc finger homeobox 1	11.1	Publications, Aliases & Descriptions, Summaries
5	UVRAG	UV radiation resistance associated gene	11.1	Summaries, Publications
6	VWA2	von Willebrand factor A domain containing 2	11.0	Expressions, Publications, Aliases & Descriptions, Orthologs
7	MSH6	mutS homolog 6 (E. coli)	11.0	Publications, Summaries
8	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0	Publications, Summaries
9	PTPRJ	protein tyrosine phosphatase, receptor type, J	11.0	Publications, Aliases & Descriptions
10	SDCCAG3P1	serologically defined colon cancer antigen 3 pseudogene 1	11.0	Aliases & Descriptions
11	FZD10	frizzled family receptor 10	11.0	Summaries
12	GPA33	glycoprotein A33 (transmembrane)	11.0	Expressions, Publications, Summaries
13	RNF43	ring finger protein 43	11.0	Expressions, Summaries
14	C18orf8	chromosome 18 open reading frame 8	11.0	Aliases & Descriptions
15	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications, Functions, UniProt Related, Summaries
16	PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	11.0	Publications, Summaries
17	SDCCAG8	serologically defined colon cancer antigen 8	11.0	Publications, Transcripts, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
18	MS4A12	membrane-spanning 4-domains, subfamily A, member 12	11.0	Publications, Summaries
19	AIFM2	apoptosis-inducing factor, mitochondrion-associated, 2	11.0	Expressions, Summaries
20	HDAC5	histone deacetylase 5	11.0	Publications, Summaries
21	RAD54B	RAD54 homolog B (S. cerevisiae)	11.0	Functions, Summaries
22	SDCCAG3P2	serologically defined colon cancer antigen 3 pseudogene 2	11.0	Aliases & Descriptions
23	SDCCAG3	serologically defined colon cancer antigen 3	11.0	Transcripts, Publications, Proteins, Aliases & Descriptions (show all 5 sections) Orthologs
24	NOXA1	NADPH oxidase activator 1	11.0	Publications, Aliases & Descriptions
25	MUC13	mucin 13, cell surface associated	11.0	Aliases & Descriptions
26	NEMF	nuclear export mediator factor	11.0	Publications, Aliases & Descriptions, Orthologs
27	STARD10	StAR-related lipid transfer (START) domain containing 10	11.0	Publications, Aliases & Descriptions
28	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	11.0	Publications, Aliases & Descriptions
29	CEP55	centrosomal protein 55kDa	11.0	Aliases & Descriptions
30	NFXL1	nuclear transcription factor, X-box binding-like 1	11.0	Aliases & Descriptions
31	STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	11.0	Publications, Aliases & Descriptions
32	CWC27	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	11.0	Publications, Aliases & Descriptions
33	KIAA1199	KIAA1199	11.0	Publications, Aliases & Descriptions
34	WNK2	WNK lysine deficient protein kinase 2	11.0	Publications, Aliases & Descriptions
35	TSHZ2	teashirt zinc finger homeobox 2	11.0	Aliases & Descriptions
36	RPS15	ribosomal protein S15	11.0	Summaries
37	ABI1	abl-interactor 1	11.0	Summaries
38	TYMS	thymidylate synthetase	11.0	Publications
39	LOC100996572	putative colon cancer-associated antigen SK1-like	11.0	Aliases & Descriptions
40	LOC100996550	putative colon cancer-associated antigen SK1-like	11.0	Aliases & Descriptions
41	LOC100996566	putative colon cancer-associated antigen SK1-like	11.0	Aliases & Descriptions
42	USHBP1	Usher syndrome 1C binding protein 1	11.0	Aliases & Descriptions
43	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Publications
44	DPYD	dihydropyrimidine dehydrogenase	11.0	Publications
45	MLH3	mutL homolog 3 (E. coli)	11.0	Publications
46	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
47	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications
48	KRT20	keratin 20	11.0	Publications
49	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	11.0	Publications
50	E2F1	E2F transcription factor 1	11.0	Publications

Pathways related to colon cancer according to GeneDecks:

(show top 50)    (show all 368)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	28.5	SGPL1, GCLC, GCNT3, SEPHS1, NAT1, NAT2
2	ERK Signaling36	23.5	PIK3R3, PIK3R1, SEMA3A, BRAF, BRF1, VEGFC
3	JAK-STAT Pathway36	22.9	PIK3R3, PIK3R1, PIAS1, SEMA3A, BRCA1, VEGFC
4	Antioxidant Action of Vitamin-C36	22.2	SEMA3A, VEGFC, BMP2, BMP4, BMP6, BMP7
5	Phospholipase-C Pathway36	22.0	SEMA3A, VEGFC, BMP2, BMP4, BMP6, BMP7
6	Cellular Apoptosis Pathway36	21.7	PIK3R3, PIK3R1, SEMA3A, VEGFC, BMP2, BMP4
7	cAMP Pathway36	21.3	PIK3R3, PIK3R1, GCG, SEMA3A, BRAF, VEGFC
8	MAPK Family Pathway36	20.0	PIK3R3, PIK3R1, SEMA3A, BRAF, VEGFC, BMP2
9	Nanog in Mammalian ESC Pluripotency36	18.8	SEMA3A, BRAF, VEGFC, BMP2, BMP4, BMP6
10	Rac1 Pathway36	18.5	PIK3R3, PIK3R1, SEMA3A, BMP4, BMP6, BMP7
11	Prostate cancer20	18.2	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, RELA
12	Endothelin-1 Signaling Pathway36	18.2	PIK3R3, PIK3R1, BRAF, MYC, BMP2, BMP4
13	UPA-UPAR Pathway36	18.0	PIK3R3, PIK3R1, SERPINE1, LAMA1, LAMA5, LAMB1
14	Integrin Pathway36	18.0	PIK3R3, PIK3R1, BRAF, VCL, MYC, RAF1
15	Telomerase Components in Cell Signaling36	17.3	RB1, SEMA3A, VEGFC, MYC, BMP2, BMP4
16	PPAR Pathway36	17.0	PIK3R3, PIK3R1, SEMA3A, VEGFC, BMP2, BMP4
17	Tuberculosis20	16.7	RELA, VDR, MYD88, RAF1, BID, BCL2
18	G12-G13 in Cellular Signaling36	16.6	PIK3R3, PIK3R1, RAF1, RAC1, CHUK, AXIN1
19	Glioma20	16.3	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, RB1
20	Ceramide Pathway36	16.1	PIK3R3, PIK3R1, RAF1, BAD, ATF3, JUN
21	IL-6 Pathway36	15.9	PIK3R3, PIK3R1, BRAF, BMP2, BMP4, BMP6
22	Endometrial cancer20	15.8	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, BRAF
23	Cytoskeleton remodeling_FAK signaling41	15.8	PIK3CB, PIK3CA, PIK3R3, PIK3R1, VEGFA, RAF1
24	Chemokine Signaling36	15.6	PIK3R3, PIK3R1, BCAR1, JUN, JAK2, FOS
25	Leukocyte transendothelial migration20	15.6	PIK3CB, PIK3R3, PIK3R1, PIK3CG, VCAM1, VCL
26	Cyclins and Cell Cycle Regulation36	15.3	RB1, RAF1, ATR, ATM, CDK6, CDKN1A
27	TRKA Signaling36	15.3	PIK3R3, PIK3R1, BRAF, MYC, RAF1, RAC1
28	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	15.2	PIK3CB, PIK3CA, PIK3R1, RAF1, BCL2, BAD
29	Development_Thrombopoietin-regulated cell processes41	14.8	PIK3CB, PIK3CA, PIK3R3, PIK3R1, BRAF, MYC
30	Prolactin Signaling36	14.7	PIK3R3, BRAF, MYC, RAF1, CEBPB, FYN
31	G1-S Phase Transition36	14.6	RB1, ATR, ATM, CDK6, CDKN1A, CDK2
32	Apoptotic Pathways Triggered By HIV136	14.5	BID, BIRC3, BCL2, BCL2L1, CHUK, BAK1
33	TNF Signaling36	14.0	BID, BIRC3, CHUK, ATF3, JUN, FOS
34	Development Flt3 signaling10	13.8	PIK3CB, PIK3CA, PIK3R1, RAF1, RAC1, PAK1
35	TNFR1 Pathway36	13.5	BID, BIRC3, PAK1, CHUK, JUN, CDC42
36	Caspase Cascade36	13.5	LMNA, BID, BIRC3, BAD, APAF1, FADD
37	Actin-Based Motility by Rho Family GTPases36	13.5	SEMA3A, BMP4, BMP7, PAK1, ITGA4, ITGA6
38	Insulin signaling pathway20	13.4	PIK3CB, PIK3CA, PIK3R3, PIK3R1, BRAF, RAF1
39	Translation _Regulation of EIF4F activity41	13.3	PIK3CB, PIK3CA, PIK3R3, PIK3R1, RAC1, PAK1
40	Fc epsilon RI signaling pathway20	13.2	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, RAC1
41	Immune response IL-9 signaling pathway10	12.9	PIK3CB, PIK3R3, RELA, RAF1, BCL3, CISH
42	Transcription Role of VDR in regulation of genes involved in osteoporosis10	12.6	VDR, JUN, CDX2, FOS, AR, IL1A
43	Immune response_MIF in innate immunity response41	12.6	RELA, MYD88, CHUK, CEBPB, JUN, MIF
44	Immune response_IL-1 signaling pathway41	12.5	RELA, SERPINE1, MYD88, CHUK, UBC, JUN
45	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	12.5	PIK3CB, PIK3R1, BAD, MAP2K2, MAP2K4, MAPK3
46	Pancreatic cancer20	11.5	PIK3R3, BRCA2, RALBP1, CDK6, AKT2
47	EGFR Inhibitor Pathway, Pharmacodynamics34	11.3	HRAS, KRAS
48	Translation Regulation activity of EIF4F10	11.3	PIK3CB, PIK3R3, PAK1, MAP2K3, AKT2, PDPK1
49	Development_EPO-induced Jak-STAT pathway41	INF	MYC, BCL2, BCL2L1, CISH, XIAP, JAK2
50	Development EPO-induced Jak-STAT pathway10	INF	MYC, RAF1, BCL2, BCL2L1, CISH, XIAP

Compounds related to colon cancer according to GeneDecks:

(show top 50)    (show all 474)

id	Compound	Score	Top Affiliating Genes
1	dexamethasone32 42 34 9 9	51.8	PIK3CA, PIK3R1, NCAM1, PDE4A, RETN, VWF
2	atp32	45.0	PIK3CB, PIK3CA, RFC1, NCAM1, PDE4A, RECK
3	genistein32 9 18 9	42.8	PIK3CA, PIK3R1, PIK3CG, PCNA, GCG, RB1
4	cholesterol32 9 18 9	37.5	PIK3CB, PIK3CA, PIK3R1, RECK, RETN, CNBP
5	glutamine32	28.7	PIK3CG, NCAM1, PDE4A, VWF, PCNA, GCG
6	sb 20358032 42	28.4	GCG, RB1, SELE, SETD2, VIM, BSG
7	heparin32 9 18 9	30.3	PIK3CA, PIK3CG, NCAM1, RECK, VWF, GCG
8	glucose32	25.5	PDE4A, GCG, SETD2, VIPR1, BRAF, VHL
9	n acetylcysteine32	24.6	VWF, PCNA, GCLC, SELE, SETD2, VCAM1
10	gemcitabine32 34 9 9	26.9	PCNA, BRCA1, VEGFA, BNIP3, MYC, RAD51
11	ascorbic acid32 18	24.8	PIK3CG, PCNA, SETD2, SERPINB2, NAT1, VDR
12	ribonucleic acid32	23.5	KLF6, SERPINB2, VEGFC, MYC, BMP2, BMP4
13	gtp32	21.4	PIK3CA, PIK3R1, RECK, CNR2, PCBD1, VIP
14	norepinephrine32 9 18 9	22.5	PDE4A, RETN, CNR1, VWF, GCG, SELE
15	cytarabine32 34 9 9	22.5	PCNA, RB1, VIM, MYC, BCL2, BCL2L1
16	adenine32 9 18 9	21.0	VWF, SETD2, NAT1, NAT2, BRAF, BRCA1
17	daunorubicin32 9 9	19.9	RELA, MYC, RAF1, RALBP1, BIRC5, BCL2
18	pdtc32	17.8	PIK3CA, PIK3CG, GCLC, SELE, SETD2, SERPINB5
19	potassium32 9 18 9	20.7	PIK3CA, NCAM1, PDE4A, VIP, BRAF, VHL
20	sphingosine32 9 18 9	20.5	PIK3R1, SGPL1, VIM, LPAR3, VCAM1, PAK1
21	hyaluronic acid32 18	18.3	VIM, MYC, BMP6, RAC1, CHI3L1, MUC1
22	histidine32	17.0	PDE4A, VHL, RAD51, RARA, PAM, KCNH2
23	ornithine32 18	18.0	KLF4, SERPINB2, MYC, RARA, CLU, MTR
24	anisomycin32 42 9 9	19.5	PIK3CG, MYC, RAF1, LDLR, MTOR, CFLAR
25	carbohydrates32	16.5	RECK, SELE, SELL, BSG, VCAM1, LGALS1
26	vanadate32	16.5	SETD2, VCL, CFTR, FYN, JAK1, JAK2
27	crcs32	16.2	PIK3CA, RB1, BRAF, BIRC5, MUC1, MUC2
28	methylmethanesulfonate32	15.9	PCNA, BRCA1, BRCA2, RAD51, BLM, PARP1
29	2-methoxyestradiol32 18	16.9	PCNA, SETD2, BID, BCL2, BCL2L1, UGT1A1
30	azathioprine32 34 9 9	18.9	PCNA, VIM, BMP2, BMP4, RARB, RAC1
31	bleomycin32 9 9	17.8	BRCA1, BRCA2, MVP, XRCC1, XRCC5, XRCC6
32	17-(allylamino)-17-demethoxygeldanamycin32	15.6	SETD2, BRAF, RAF1, BIRC5, CHEK1, CHEK2
33	cytosine32 18	16.3	SERPINB5, SERPINB2, BRCA1, MYB, RAD51, LCP1
34	noxa32	15.3	BID, BIRC5, BCL2, BCL2L1, BBC3, BAD
35	fludarabine32 9 9	17.2	BID, BIRC3, BIRC5, PARP1, BCL2, BCL2L1
36	mitoxantrone32 9 9	17.0	BIRC5, BCL2, MVP, MTOR, ATM, FLT3
37	chelerythrine32	14.2	PIK3CG, CFLAR, CDKN3, FOS, FN1, MBP
38	cadmium32 18	14.9	BID, BACH1, XRCC1, XPA, B2M, ATP7B
39	dithiothreitol32	13.8	VWF, SERPINB2, NAT1, UGT1A1, AZU1, APEX1
40	mptp32	13.7	VDR, BNIP3, BCL2, BCL2L1, CHRNA7, BAX
41	metformin32 34 9 9	16.6	PIK3CA, PIK3CG, RETN, CNR1, VWF, GCG
42	inositol32	13.6	PIK3CB, PDE4A, CHGA, CHRM3, GSK3B, GSN
43	fulvestrant32 34 9 9	16.2	PIK3CG, PCNA, AR, MAPK10, MAPK1, IGFBP3
44	methylcellulose32	12.7	VCL, MYB, BMP2, CDH1, FLT3LG, FLT3
45	pravastatin32 34 9 18 9	16.4	SELE, SERPINE1, BMP2, RAC1, CHKA, LDLR
46	pentoxifylline32 9 9	13.9	PDE4A, SELL, VCAM1, BMP2, BMP6, CD9
47	cyclophosphamide32 34 9 9	14.6	MVP, ITGA4, ITGB2, FLT3LG, LTF, TAC1
48	il 1032	10.1	VDR, BMP6, CD40, IL10, IL12B, IL15
49	threonine32	INF	PIM3, RBL2, LPAR3, BMP2, BMPR1A, BMPR2
50	Adenosine triphosphate9 18 9	INF	PIK3CB, PIK3CA, PIM3, PIK3CG, BUB1B, GCLC

Cellular components related to colon cancer according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	71.3	ZNF165, PIK3CB, PIAS2, PIAS1, PIDD, KLF5
2	plasma membrane	GO:005886	46.0	PIK3R1, PIK3CG, LRP6, NCAM1, RECK, CNR1
3	nucleoplasm	GO:005654	35.6	ZNF143, PIAS1, RFC1, NCOR2, RELA, PCNA
4	extracellular region	GO:005576	30.2	NCAM1, REG4, RETN, RETNLB, VWF, GCG
5	integral to plasma membrane	GO:005887	26.9	CNR1, CNR2, SELL, VIPR1, LPAR1, LPAR2
6	extracellular space	GO:005615	25.7	SFN, PCSK5, GCG, GC, SELE, SERPINB5
7	membrane	GO:016020	21.8	PIK3CG, PDE4A, RECK, GCNT3, SEMA3A, VHL
8	perinuclear region of cytoplasm	GO:048471	18.8	PDE4A, BUB1B, GC, SELE, LMNA, RAD51
9	cell surface	GO:009986	17.7	LRP6, NCAM1, VEGFA, LPAR1, LPAR2, VCAM1
10	membrane raft	GO:045121	13.7	SELE, BSG, JAK2, CD36, CD55, ITGA1
11	external side of plasma membrane	GO:009897	13.5	NCAM1, VWF, SELL, VCAM1, KDR, LDLR
12	cytosol	GO:005829	INF	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, PDCD4
13	cytoplasm	GO:005737	INF	PIM3, PIDD, PIK3CG, LRRC26, KLF6, RGCC

Biological processes related to colon cancer according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	32.2	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, NCOR2
2	signal transduction	GO:007165	30.6	PIK3CB, PIDD, PDE4A, SFN, GCG, BTRC
3	apoptotic process	GO:006915	29.9	PIM3, PIDD, PDCD4, SGPL1, SFN, BUB1B
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	24.8	PIAS2, LRP6, KLF4, KLF6, RELA, CNBP
5	positive regulation of transcription, DNA-dependent	GO:045893	23.7	PIAS2, PIAS1, LRP6, KLF4, KLF5, KLF6
6	positive regulation of cell proliferation	GO:008284	23.2	KLF5, CNBP, VIP, VIPR1, VEGFA, VEGFC
7	blood coagulation	GO:007596	22.9	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, KIF18A
8	negative regulation of transcription from RNA polymerase II promoter	GO:000122	22.6	KLF4, NCOR2, VHL, VDR, MYC, MYB
9	response to drug	GO:042493	22.2	PDE4A, VEGFC, MYC, PAM, BCL2, LGALS1
10	negative regulation of cell proliferation	GO:008285	21.9	KLF4, RGCC, SFN, VHL, VDR, BMP2
11	negative regulation of transcription, DNA-dependent	GO:045892	20.2	KLF4, PDCD4, RELA, GCLC, BTRC, RB1
12	virus-host interaction	GO:019048	19.9	PIK3R1, RELA, BTRC, RB1, RBL1, VIM
13	cell adhesion	GO:007155	19.0	NCAM1, VWF, SELL, VCAM1, VCL, RAC1
14	anti-apoptosis	GO:006916	18.8	PIK3CA, RELA, GCLC, SERPINB2, VNN1, NAIP
15	innate immune response	GO:045087	18.3	PIK3CG, RELA, VNN1, MYD88, CLU, BCL2
16	inflammatory response	GO:006954	18.2	PIK3CG, RELA, CNR2, SELE, VNN1, MYD88
17	nerve growth factor receptor signaling pathway	GO:048011	18.1	PIK3CB, PIK3CA, PIK3R1, RELA, PCSK5, BRAF
18	angiogenesis	GO:001525	17.7	PIK3CA, PIK3CG, KLF5, SETD2, SERPINE1, VEGFA
19	platelet activation	GO:030168	17.3	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, VWF
20	epidermal growth factor receptor signaling pathway	GO:007173	16.9	PIK3CA, PIK3R1, VIL1, RAF1, BCAR1, CHUK
21	positive regulation of cell migration	GO:030335	16.9	VIL1, VEGFA, BMP2, KDR, BCAR1, LEF1
22	response to hypoxia	GO:001666	16.6	VEGFA, VCAM1, BNIP3, BMP2, RAF1, PAK1
23	induction of apoptosis	GO:006917	16.1	BNIP3, ZMAT3, PAWR, BBC3, BAD, BAX
24	regulation of apoptotic process	GO:042981	16.0	BRCA1, LMNA, RAF1, BIRC5, BCAR1, BCL3
25	phosphatidylinositol-mediated signaling	GO:048015	15.9	PIK3CB, PIK3CA, PIK3R1, PCNA, BUB1B, CHUK
26	heart development	GO:007507	15.8	PCNA, PCSK5, VCAM1, BMP2, RAF1, PAM
27	response to lipopolysaccharide	GO:032496	15.8	CNR1, CNR2, SELE, UGT1A1, S100A9, CEBPB
28	response to organic cyclic compound	GO:014070	15.7	BMP4, LEF1, UGT1A1, BAK1, MSH2, JUN
29	induction of apoptosis by intracellular signals	GO:008629	15.7	BNIP3, MYC, BID, CLU, BCL2, BCL2L1
30	insulin receptor signaling pathway	GO:008286	15.7	PIK3CB, PIK3CA, PIK3R3, PIK3R1, RAF1, BCAR1
31	transforming growth factor beta receptor signaling pathway	GO:007179	15.4	NCOR2, RBL1, SERPINE1, MYC, BMPR1A, PARP1
32	fibroblast growth factor receptor signaling pathway	GO:008543	15.3	PIK3CA, PIK3R1, BRAF, RAF1, CHUK, UBC
33	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	15.1	SENP1, MYC, BBC3, BAD, BAX, XDH
34	positive regulation of protein phosphorylation	GO:001934	14.7	VEGFA, BMP2, BMP4, MTOR, AXIN1, AXIN2
35	aging	GO:007568	14.7	CNR1, VDR, VCAM1, BAK1, JUN, GSN
36	response to estradiol stimulus	GO:032355	14.6	GC, BRCA2, VDR, BMP4, RARA, BID
37	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	14.3	RELA, LPAR1, MYD88, BIRC3, LGALS1, CHUK
38	cytokine-mediated signaling pathway	GO:019221	14.1	PIAS1, KLF6, NCAM1, RELA, VCAM1, MYD88
39	cellular response to hypoxia	GO:071456	14.0	RGCC, VHL, VEGFA, LMNA, BNIP3, BMP7
40	cellular response to mechanical stimulus	GO:071260	13.9	BNIP3, MYD88, CHEK1, BAD, BAK1, CD40
41	activation of MAPK activity	GO:000187	13.9	PIK3CB, LPAR1, LPAR2, LPAR3, CHRNA7, UBC
42	response to ethanol	GO:045471	13.7	CNR1, BCL2, CHAT, BAK1, S100A9, FYN
43	positive regulation of peptidyl-serine phosphorylation	GO:033138	13.6	PIK3CA, GCG, BRAF, VEGFA, RAF1, PAK1
44	positive regulation of ERK1 and ERK2 cascade	GO:070374	13.5	GCG, BRAF, BMP2, BMP4, KDR, CHI3L1
45	positive regulation of MAPK cascade	GO:043410	13.1	LPAR1, LPAR2, LPAR3, KDR, LEP, CD36
46	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.7	VEGFA, MTOR, JAK2, CD36, CD80, CD44
47	regulation of cell proliferation	GO:042127	INF	RBFOX2, SERPINE1, BRCA1, BMPR2, BID, BIRC7
48	protein autophosphorylation	GO:046777	INF	PAK1, KDR, CHEK2, MTOR, AURKA, AURKB
49	cell proliferation	GO:008283	INF	RETNLB, SFN, PCNA, BUB1B, GCG, BOP1
50	protein phosphorylation	GO:006468	INF	PIM3, BRAF, BMPR1A, RARA, RAF1, BIRC5

Molecular functions related to colon cancer according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	92.5	ZNF165, ZNF143, PIK3CB, PIAS2, PIK3CA, PIK3R1
2	sequence-specific DNA binding transcription factor activity	GO:003700	24.4	ZNF165, KLF4, KLF5, KLF6, RELA, CNBP
3	protein homodimerization activity	GO:042803	21.3	LRP6, VWF, VIL1, VEGFA, BNIP3, BMP2
4	protein kinase binding	GO:019901	19.0	RGCC, RELA, VIM, ZFP36, PAK1, BCAR1
5	enzyme binding	GO:019899	18.6	PIAS1, BRCA1, VHL, RARA, RAC1, BIRC5
6	identical protein binding	GO:042802	18.5	RELA, VWA2, PCBD1, PCNA, VIL1, VIM
7	transcription factor binding	GO:008134	18.4	RELA, RB1, RBFOX2, RBL1, VHL, MYC
8	protein heterodimerization activity	GO:046982	18.3	BRAF, VEGFA, BNIP3, MYC, BMP2, BMP6
9	transcription regulatory region DNA binding	GO:044212	15.4	KLF4, RELA, BRCA1, LEF1, XRCC5, XRCC6
10	double-stranded DNA binding	GO:003690	15.0	KLF4, KLF6, MYC, RAD51, ZEB1, YBX1
11	beta-catenin binding	GO:008013	13.9	BTRC, VCL, LEF1, AXIN1, AXIN2, CDH2
12	growth factor activity	GO:008083	13.8	VEGFA, VEGFC, BMP2, BMP4, BMP6, BMP7
13	integrin binding	GO:005178	13.0	VWF, VCAM1, KDR, LAMA5, LAMB1, LAMB2
14	cytokine activity	GO:005125	12.8	VEGFA, BMP2, BMP4, BMP6, BMP7, CD40LG
15	ATP binding	GO:005524	INF	PIK3CB, PIK3CA, PIM3, PIK3CG, RFC1, KIF18A
16	protein tyrosine kinase activity	GO:004713	INF	KDR, YES1, FYN, JAK1, JAK2, FGFR1