MCID: CLN016
MIFTS: 67

Colon Cancer malady

Cancer diseases, Gastrointestinal diseases categories

Summaries for Colon Cancer

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

MalaCards: Colon Cancer, also known as colon carcinoma, is related to colorectal cancer and breast cancer. An important gene associated with Colon Cancer is AURKA (aurora kinase A), and among its related pathways are Oocyte meiosis and Development EGFR signaling pathway. The compounds cetuximab and crcs have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and breast, and related mouse phenotypes are tumorigenesis and growth/size.

Description from OMIM:46 114500

Aliases & Classifications for Colon Cancer

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8Disease Ontology, 20GeneTests, 22GTR, 46OMIM, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon cancer 8 46 44
colon carcinoma 8 44 60
colon neoplasm 8 20 22
carcinoma of colon 8
colorectal cancer 60
colonic carcinoma 8
neoplasm of colon 8
colonic neoplasm 8
colonic tumor 8
colonic mass 8


Related Diseases for Colon Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Colon Cancer family:

Colon Carcinoma in Situ

Diseases related to Colon Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 449)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.0CTNNB1, AURKA, BRAF
2breast cancer30.9CTNNB1, AURKA
3lynch syndrome30.8BRAF
4adenoma30.7BRAF, CTNNB1
5prostate cancer30.4CTNNB1, MT-CO1
6thyroid cancer30.3BRAF
7cholangiocarcinoma30.0BRAF
8squamous cell carcinoma29.9CTNNB1, AURKA, MT-CO1
9cervical cancer29.8BRAF
10papillary thyroid carcinoma29.8BRAF, CTNNB1
11endometrial carcinoma29.8CTNNB1, BRAF
12vascular cancer10.8
13colonic disease10.7
14cell type cancer10.6
15lymph node cancer10.6
16ascending colon cancer10.6
17transverse colon cancer10.6
18lung cancer10.6
19hepatitis10.5
20colon adenocarcinoma10.5
21adenocarcinoma10.5
22inflammatory bowel disease10.4
23familial adenomatous polyposis10.4
24ulcerative colitis10.4
25ovarian cancer10.4
26mutyh-associated polyposis10.4
27descending colon cancer10.4
28leukemia10.3
29obesity10.3
30familial colorectal cancer10.3
31peritonitis10.3
32prostatitis10.3
33neutropenia10.3
34oligodontia-colorectal cancer syndrome10.3
35in situ carcinoma10.3
36pancreatic cancer10.3
37pancreatitis10.3
38neuronitis10.2
39constipation10.2
40interstitial lung disease10.2
41colon lymphoma10.2
42diverticulitis of colon10.2
43diverticulitis10.2
44melanoma10.2
45thyroiditis10.2
46neuroendocrine carcinoma10.2
47thyroid lymphoma10.2
48ataxia telangiectasia10.2
49cronkhite-canada syndrome10.2
50rectal prolapse10.2

Graphical network of the top 20 diseases related to Colon Cancer:



Diseases related to colon cancer

Clinical Features for Colon Cancer

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46OMIM
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Clinical features from OMIM:

114500

Drugs & Therapeutics for Colon Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colon Cancer

Drug clinical trials:

Search ClinicalTrials for Colon Cancer

Search NIH Clinical Center for Colon Cancer

Search CenterWatch for Colon Cancer

Genetic Tests for Colon Cancer

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20GeneTests, 22GTR
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Genetic tests related to Colon Cancer:

id Genetic test Affiliating Genes
1 Colon Cancer (apc I1307k Related)20 APC
2 Carcinoma of Colon22

Anatomical Context for Colon Cancer

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32MalaCards
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MalaCards organs/tissues related to Colon Cancer:

32
Colon, Liver, Breast, Endothelial, Lung, Lymph node, T cells, Appendix, Prostate, Testes, Bone, Thyroid, Bone marrow, Kidney, Pancreas, Monocytes, Skin, Ovary, Testis, Small intestine, Cervix, Pituitary, B cells, Myeloid, Brain, Cortex, Pancreatic islet, Nk cells, Spleen, Whole blood, Heart, Fetal liver

Animal Models for Colon Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colon Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7BRAF, AURKA, CTNNB1
2MP:00053788.0BRAF, AURKA, CTNNB1, MT-CO1
3MP:00053847.7BRAF, AURKA, CTNNB1, MT-CO1

Publications for Colon Cancer

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50PubMed
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Articles related to Colon Cancer:

(show top 50)    (show all 4240)
idTitleAuthorsYear
1
Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. (24418929)
2014
2
Exposure to ACEI/ARB and I^-Blockers Is Associated with Improved Survival and Decreased Tumor Progression and Hospitalizations in Patients with Advanced Colon Cancer. (24151534)
2013
3
The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. (23773923)
2013
4
You're the flight surgeon: colon cancer. (24261069)
2013
5
Microsatellite instability and loss of heterozygosity detected in middle-aged patients with sporadic colon cancer: A retrospective study. (24179534)
2013
6
Epithelial-mesenchymal transition associates with maintenance of stemness in spheroid-derived stem-like colon cancer cells. (24039918)
2013
7
Up-regulation of FXR isoforms is not required for stimulation of the expression of genes involved in the lack of response of colon cancer to chemotherapy. (22898327)
2012
8
Lactic acidosis and colon cancer: oncologic emergency? (21855042)
2011
9
Effect of COX-2 inhibitor on the expression of BCL-3 and cyclin D1 in human colon cancer cell line SW480]. (20737317)
2010
10
RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. (20122401)
2010
11
Hereditary colon cancer: lynch syndrome. (20559516)
2010
12
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. (20046424)
2009
13
Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. (19054763)
2009
14
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. (18299982)
2008
15
Nuclear receptors, intestinal architecture and colon cancer: an intriguing link. (18278436)
2008
16
Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly. (18562041)
2008
17
Genetic variation in calcium-sensing receptor and risk for colon cancer. (18843020)
2008
18
Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines. (17904248)
2008
19
Fatal toxic epidermal necrolysis associated with cetuximab in a patient with colon cancer. (18509187)
2008
20
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis. (18176934)
2008
21
Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. (17941089)
2008
22
A novel dendritic cell-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model. (17275030)
2007
23
Early apoptosis and cell death induced by ATX-S10Na (II)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells. (17278191)
2007
24
Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. (17890272)
2007
25
Epidermal growth factor (EGF) A61G polymorphism and EGF gene expression in normal colon tissue from patients with colorectal cancer. (17851837)
2007
26
Protein pattern difference in the colon cancer cell lines examined by two-dimensional differential in-gel electrophoresis and mass spectrometry. (17123137)
2006
27
Cyclooxygenase-2 knockdown by RNA interference in colon cancer. (16391811)
2006
28
Antitumor activity of chimeric immunoreceptor gene-modified Tc1 and Th1 cells against autologous carcinoembryonic antigen-expressing colon cancer cells. (16856879)
2006
29
Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. (16170359)
2006
30
Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer. (16365013)
2005
31
Expressions of cyclooxygenase-2 and cholecystokinin-B receptor mRNA in human colonic cancer and their significances]. (15694043)
2005
32
TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. (16157217)
2005
33
Analysis of glycoproteins in human colon cancers, normal tissues and in human colon carcinoma cells reactive with monoclonal antibody NCL-19-9. (16077981)
2005
34
Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients. (15571263)
2004
35
The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells. (14712211)
2004
36
Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery. (15622584)
2004
37
Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. (15161648)
2004
38
Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. (12767532)
2003
39
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. (14583469)
2003
40
Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells. (14688479)
2003
41
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. (11950812)
2002
42
Heparin-derived disaccharides modulate proliferation and Erb-B2-mediated signal transduction in colon cancer cell lines. (11979431)
2002
43
p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents. (11279192)
2001
44
Small sigmoid colon cancer with liver metastasis. (10192625)
1999
45
High gastrin releasing peptide receptor mRNA level is related to tumour dedifferentiation and lymphatic vessel invasion in human colon cancer. (10211100)
1999
46
Folic acid inhibition of EGFR-mediated proliferation in human colon cancer cell lines. (10600765)
1999
47
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells. (9657039)
1998
48
Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer. (8378090)
1993
49
IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons. (1563100)
1992
50
Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase- specific probe. (1353685)
1992

Genetic Variations for Colon Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Colon Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colon Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colon Cancer

Search GEO for disease gene expression data for Colon Cancer.

Pathways for genes affiliated with Colon Cancer

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29KEGG, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database
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Compounds for genes affiliated with Colon Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Colon Cancer according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cetuximab44 49 1111.6CTNNB1, BRAF
2crcs449.5CTNNB1, BRAF
3geldanamycin44 49 59 1112.4CTNNB1, BRAF
4p002449.3CTNNB1, BRAF
5imatinib44 49 1111.3CTNNB1, BRAF
6paclitaxel44 49 1111.0BRAF, CTNNB1, AURKA
7aspartate449.0CTNNB1, AURKA, BRAF
8threonine448.9BRAF, AURKA, CTNNB1
9estrogen448.7BRAF, AURKA, CTNNB1
10fatty acid448.7BRAF, MT-CO1, CTNNB1
11atp44 289.2CTNNB1, BRAF, MT-CO1

GO Terms for genes affiliated with Colon Cancer

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Products for genes affiliated with Colon Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colon Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet