MCID: CLN016
MIFTS: 67

Colon Cancer malady

Cancer diseases, Gastrointestinal diseases categories

Summaries for Colon Cancer

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

MalaCards: Colon Cancer, also known as colon carcinoma, is related to colorectal cancer and breast cancer. An important gene associated with Colon Cancer is AURKA (aurora kinase A), and among its related pathways are Oocyte meiosis and Colorectal Cancer Metastasis. The compounds cetuximab and crcs have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and breast, and related mouse phenotypes are tumorigenesis and growth/size.

Description from OMIM:46 114500

Aliases & Classifications for Colon Cancer

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8Disease Ontology, 46OMIM, 44Novoseek, 60UMLS, 20GeneTests, 22GTR, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon cancer 8 46 44
colon carcinoma 8 44 60
colon neoplasm 8 20 22
carcinoma of colon 8
colorectal cancer 60
colonic carcinoma 8
neoplasm of colon 8
colonic neoplasm 8
colonic tumor 8
colonic mass 8


Related Diseases for Colon Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Colon Cancer family:

Colon Carcinoma in Situ

Diseases related to Colon Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 449)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.0CTNNB1, AURKA, BRAF
2breast cancer30.9CTNNB1, AURKA
3lynch syndrome30.8BRAF
4adenoma30.7BRAF, CTNNB1
5prostate cancer30.4CTNNB1, MT-CO1
6thyroid cancer30.3BRAF
7cholangiocarcinoma30.0BRAF
8squamous cell carcinoma29.9CTNNB1, AURKA, MT-CO1
9cervical cancer29.8BRAF
10papillary thyroid carcinoma29.8BRAF, CTNNB1
11endometrial carcinoma29.8CTNNB1, BRAF
12vascular cancer10.8
13colonic disease10.7
14cell type cancer10.6
15lymph node cancer10.6
16ascending colon cancer10.6
17transverse colon cancer10.6
18lung cancer10.6
19hepatitis10.5
20colon adenocarcinoma10.5
21adenocarcinoma10.5
22inflammatory bowel disease10.4
23familial adenomatous polyposis10.4
24ulcerative colitis10.4
25ovarian cancer10.4
26mutyh-associated polyposis10.4
27descending colon cancer10.4
28leukemia10.3
29obesity10.3
30familial colorectal cancer10.3
31peritonitis10.3
32prostatitis10.3
33neutropenia10.3
34oligodontia-colorectal cancer syndrome10.3
35in situ carcinoma10.3
36pancreatic cancer10.3
37pancreatitis10.3
38neuronitis10.2
39constipation10.2
40interstitial lung disease10.2
41colon lymphoma10.2
42diverticulitis of colon10.2
43diverticulitis10.2
44melanoma10.2
45thyroiditis10.2
46neuroendocrine carcinoma10.2
47thyroid lymphoma10.2
48ataxia telangiectasia10.2
49cronkhite-canada syndrome10.2
50rectal prolapse10.2

Graphical network of the top 20 diseases related to Colon Cancer:



Diseases related to colon cancer

Clinical Features for Colon Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

114500

Drugs & Therapeutics for Colon Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colon Cancer

Drug clinical trials:

Search ClinicalTrials for Colon Cancer

Search NIH Clinical Center for Colon Cancer

Search CenterWatch for Colon Cancer

Genetic Tests for Colon Cancer

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20GeneTests, 22GTR
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Genetic tests related to Colon Cancer:

id Genetic test Affiliating Genes
1 Colon Cancer (apc I1307k Related)20 APC
2 Carcinoma of Colon22

Anatomical Context for Colon Cancer

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32MalaCards
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MalaCards organs/tissues related to Colon Cancer:

32
Colon, Liver, Breast, Endothelial, Lung, Lymph node, T cells, Appendix, Prostate, Testes, Bone, Thyroid, Pancreas, Kidney, Bone marrow, Monocytes, Testis, Ovary, Skin, B cells, Brain, Myeloid, Cervix, Pituitary, Small intestine, Heart, Nk cells, Cortex, Fetal liver, Whole blood, Pancreatic islet, Spleen

Animal Models for Colon Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colon Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CTNNB1, AURKA, BRAF
2MP:00053788.0MT-CO1, CTNNB1, AURKA, BRAF
3MP:00053847.7BRAF, AURKA, CTNNB1, MT-CO1

Publications for Colon Cancer

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50PubMed
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Articles related to Colon Cancer:

(show top 50)    (show all 4240)
idTitleAuthorsYear
1
Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells. (23142292)
2013
2
Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells. (23739740)
2013
3
Hematogenous umbilical metastasis from colon cancer treated by palliative single-incision laparoscopic surgery. (24179626)
2013
4
DNA Testing and Molecular Screening for Colon Cancer. (24355100)
2013
5
Conventional adverse features do not predict response to adjuvant chemotherapy in stage II colon cancer. (24224835)
2013
6
Effects of ethanol extract of Radix Sophorae Flavescentis on activity of colon cancer HT29 cells. (24311849)
2013
7
CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1. (23098564)
2012
8
Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients. (21823122)
2012
9
Prognostic value of hedgehog signaling pathway in patients with colon cancer. (21424326)
2012
10
Curative resection of transverse colon cancer via minilaparotomy. (21675613)
2011
11
Colon cancer cells produce immunoregulatory glucocorticoids. (21258413)
2011
12
Basidiobolomycosis of the colon masquerading as stenotic colon cancer. (22606589)
2011
13
HERG K+ channel related chemosensitivity to sparfloxacin in colon cancer cells. (20428834)
2010
14
Hormone therapy, DNA methylation and colon cancer. (20064828)
2010
15
Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells. (20530554)
2010
16
Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer. (20119979)
2010
17
Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo. (19308290)
2009
18
Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. (19480695)
2009
19
Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity. (19782697)
2009
20
Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. (19440933)
2009
21
LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells. (19661305)
2009
22
Enhanced proliferation of SNU-407 human colon cancer cells by muscarinic acetylcholine receptors. (19017493)
2008
23
Mechanism of resistance to chemoradiation in p53 mutant human colon cancer. (18497992)
2008
24
Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells. (17551074)
2007
25
Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines. (17685394)
2007
26
A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells. (17285135)
2007
27
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. (17090686)
2006
28
Compensatory increases in Her-2/neu activation in response to EGFR tyrosine kinase inhibition in colon cancer cell lines. (17059835)
2006
29
Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. (16475687)
2006
30
Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. (16158974)
2005
31
The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. (15665104)
2005
32
Lymphatic metastasis and nm23H1 genetic instability in Chinese colon cancer patients. (15334673)
2004
33
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (15308583)
2004
34
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. (15483017)
2004
35
Increased expression of a Myc target gene Mina53 in human colon cancer. (14695334)
2004
36
Expression and significance of survivin in colon cancer]. (15566647)
2004
37
Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea. (15533596)
2004
38
The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer. (12751768)
2003
39
Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. (14500353)
2003
40
The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. (12679318)
2003
41
Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. (12958170)
2003
42
Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines. (12763222)
2003
43
Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs. (11953891)
2002
44
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. (11245474)
2001
45
Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers. (11093935)
2000
46
Regulatory network of mitomycin C action in human colon cancer cells. (10391098)
1999
47
Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs. (7524348)
1994
48
Altered eicosanoid levels in human colon cancer. (8228569)
1993
49
Tumor markers in cancer of the colon and rectum. (2036931)
1991
50
Colon cancer in the Cronkhite-Canada syndrome. (3745857)
1986

Genetic Variations for Colon Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Colon Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colon Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colon Cancer

Search GEO for disease gene expression data for Colon Cancer.

Pathways for genes affiliated with Colon Cancer

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Colon Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Colon Cancer according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cetuximab44 49 1111.6CTNNB1, BRAF
2crcs449.5CTNNB1, BRAF
3geldanamycin44 49 59 1112.4BRAF, CTNNB1
4p002449.3CTNNB1, BRAF
5imatinib44 49 1111.3CTNNB1, BRAF
6paclitaxel44 49 1111.0CTNNB1, AURKA, BRAF
7aspartate449.0CTNNB1, AURKA, BRAF
8threonine448.9CTNNB1, AURKA, BRAF
9estrogen448.7BRAF, AURKA, CTNNB1
10fatty acid448.7BRAF, CTNNB1, MT-CO1
11atp44 289.2MT-CO1, CTNNB1, BRAF

GO Terms for genes affiliated with Colon Cancer

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Products for genes affiliated with Colon Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colon Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet