MCID: CLN016
MIFTS: 67

Colon Cancer malady

Cancer diseases, Gastrointestinal diseases categories

Summaries for Colon Cancer

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

MalaCards: Colon Cancer, also known as colon carcinoma, is related to colorectal cancer and breast cancer. An important gene associated with Colon Cancer is AURKA (aurora kinase A), and among its related pathways are Oocyte meiosis and Colorectal Cancer Metastasis. The compounds cetuximab and crcs have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and breast, and related mouse phenotypes are tumorigenesis and growth/size.

Description from OMIM:46 114500

Aliases & Classifications for Colon Cancer

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8Disease Ontology, 46OMIM, 44Novoseek, 60UMLS, 20GeneTests, 22GTR, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colon cancer 8 46 44
colon carcinoma 8 44 60
colon neoplasm 8 20 22
carcinoma of colon 8
colorectal cancer 60
colonic carcinoma 8
neoplasm of colon 8
colonic neoplasm 8
colonic tumor 8
colonic mass 8


Related Diseases for Colon Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Colon Cancer family:

Colon Carcinoma in Situ

Diseases related to Colon Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 449)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.0CTNNB1, AURKA, BRAF
2breast cancer30.9CTNNB1, AURKA
3lynch syndrome30.8BRAF
4adenoma30.7BRAF, CTNNB1
5prostate cancer30.4CTNNB1, MT-CO1
6thyroid cancer30.3BRAF
7cholangiocarcinoma30.0BRAF
8squamous cell carcinoma29.9CTNNB1, AURKA, MT-CO1
9cervical cancer29.8BRAF
10papillary thyroid carcinoma29.8BRAF, CTNNB1
11endometrial carcinoma29.8CTNNB1, BRAF
12vascular cancer10.8
13colonic disease10.7
14cell type cancer10.6
15lymph node cancer10.6
16ascending colon cancer10.6
17transverse colon cancer10.6
18lung cancer10.6
19hepatitis10.5
20colon adenocarcinoma10.5
21adenocarcinoma10.5
22inflammatory bowel disease10.4
23familial adenomatous polyposis10.4
24ulcerative colitis10.4
25ovarian cancer10.4
26mutyh-associated polyposis10.4
27descending colon cancer10.4
28leukemia10.3
29obesity10.3
30familial colorectal cancer10.3
31peritonitis10.3
32prostatitis10.3
33neutropenia10.3
34oligodontia-colorectal cancer syndrome10.3
35in situ carcinoma10.3
36pancreatic cancer10.3
37pancreatitis10.3
38neuronitis10.2
39constipation10.2
40interstitial lung disease10.2
41colon lymphoma10.2
42diverticulitis of colon10.2
43diverticulitis10.2
44melanoma10.2
45thyroiditis10.2
46neuroendocrine carcinoma10.2
47thyroid lymphoma10.2
48ataxia telangiectasia10.2
49cronkhite-canada syndrome10.2
50rectal prolapse10.2

Graphical network of the top 20 diseases related to Colon Cancer:



Diseases related to colon cancer

Clinical Features for Colon Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

114500

Drugs & Therapeutics for Colon Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colon Cancer

Drug clinical trials:

Search ClinicalTrials for Colon Cancer

Search NIH Clinical Center for Colon Cancer

Search CenterWatch for Colon Cancer

Genetic Tests for Colon Cancer

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20GeneTests, 22GTR
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Genetic tests related to Colon Cancer:

id Genetic test Affiliating Genes
1 Colon Cancer (apc I1307k Related)20 APC
2 Carcinoma of Colon22

Anatomical Context for Colon Cancer

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32MalaCards
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MalaCards organs/tissues related to Colon Cancer:

32
Colon, Liver, Breast, Endothelial, Lung, Lymph node, T cells, Appendix, Prostate, Testes, Bone, Thyroid, Pancreas, Kidney, Bone marrow, Monocytes, Testis, Ovary, Skin, B cells, Brain, Myeloid, Cervix, Pituitary, Small intestine, Heart, Nk cells, Cortex, Fetal liver, Whole blood, Pancreatic islet, Spleen

Animal Models for Colon Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colon Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CTNNB1, AURKA, BRAF
2MP:00053788.0MT-CO1, CTNNB1, AURKA, BRAF
3MP:00053847.7BRAF, AURKA, CTNNB1, MT-CO1

Publications for Colon Cancer

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50PubMed
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Articles related to Colon Cancer:

(show top 50)    (show all 4240)
idTitleAuthorsYear
1
Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression. (24422988)
2014
2
Obesity, outcomes and quality of care: body mass index increases the risk of wound-related complications in colon cancer surgery. (24139555)
2014
3
Identifying colon cancer risk modules with better classification performance based on human signaling network. (24239682)
2013
4
Increased expression of TRPS1 affects tumor progression and correlates with patients' prognosis of colon cancer. (23762846)
2013
5
Protein-bound polysaccharide K reduced the invasive ability of colon cancer cell lines. (24222121)
2013
6
Augmented cytotoxicity of hydroxycamptothecin-loaded nanoparticles in lung and colon cancer cells by chemosensitizing pharmaceutical excipients. (24093513)
2013
7
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. (21624135)
2011
8
The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells. (21966538)
2011
9
The plasminogen activator inhibitor system in colon cancer cell lines is influenced by the CO2 pneumoperitoneum. (20931209)
2011
10
Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1I+/CXCR4 paracrine signaling. (21969820)
2011
11
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. (21987656)
2011
12
Pdcd4, a colon cancer prognostic that is regulated by a microRNA. (19836969)
2010
13
Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation. (19962968)
2010
14
Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance. (19593667)
2009
15
Editorial retraction. Down-regulation of human telomerase reverse transcriptase through anti-c-myc siRNA in human colon cancer Colo 320 cells. (20183618)
2009
16
Association of H-ras polymorphisms and susceptibility to sporadic colon cancer. (19787272)
2009
17
Vitamin D receptor expression is associated with colon cancer in ulcerative colitis. (19787215)
2009
18
Association of vitamin D receptor gene variants, adiposity and colon cancer. (18628249)
2008
19
99mTc-labeled bombesin(7-14)NH2 with favorable properties for SPECT imaging of colon cancer. (18491928)
2008
20
Expression of galectin-3 in the tumor immune response in colon cancer. (18542048)
2008
21
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. (18281498)
2008
22
Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. (20424651)
2008
23
Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. (17487373)
2007
24
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. (17631291)
2007
25
Gastrin 1-6 promotes growth of colon cancer cells through non-CCK receptors. (17126952)
2007
26
Expression of MMP-2, HIF-1alpha and VEGF in colon adenoma and colon cancer]. (18172354)
2007
27
Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. (17220595)
2007
28
Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells. (16832341)
2007
29
Regulation of human neurotropic JCV in colon cancer cells. (16619477)
2006
30
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. (16772118)
2006
31
let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. (16651716)
2006
32
Suprarenal Clostridium septicum aortitis with rupture and simultaneous colon cancer. (16773491)
2006
33
Targeted agents for adjuvant therapy of colon cancer. (17178286)
2006
34
Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. (16230369)
2005
35
Irinotecan/5-fluorouracil combination induces alterations in mitochondrial membrane potential and caspases on colon cancer cell lines. (16491956)
2005
36
Apoptosis induced by oxaliplatin in human colon cancer HCT15 cell line. (15015600)
2004
37
Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment. (14985462)
2004
38
Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis. (15310763)
2004
39
The role of the Deleted Colon Cancer (DCC) gene in colorectal and gastric cancer. (12901294)
2003
40
Strategies for the purification of laminin-10 for studies on colon cancer metastasis. (12717810)
2003
41
TR3/Nur77 in colon cancer cell apoptosis. (14500374)
2003
42
Resistance to apoptosis is increased during metastatic dissemination of colon cancer. (11964082)
2002
43
Successful resection of sigmoid colon cancer in a patient with factor XI deficiency. (9585681)
1998
44
Expression of beta-galactoside alpha 2,6-sialyltransferase does not alter the susceptibility of human colon cancer cells to NK-mediated cell lysis. (9184831)
1997
45
Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line. (8911123)
1996
46
Colon cancer mucin: a new ligand for the beta-galactoside-binding protein galectin-3. (8813123)
1996
47
Amiloride modulates urokinase gene expression at both transcription and post-transcription levels in human colon cancer cells. (7750207)
1995
48
Nonspecific cross-reacting antigen 50/90 is elevated in patients with breast, lung, and colon cancer. (8118811)
1994
49
The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro. (7923106)
1994
50
Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. (7903889)
1993

Genetic Variations for Colon Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Colon Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colon Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colon Cancer

Search GEO for disease gene expression data for Colon Cancer.

Pathways for genes affiliated with Colon Cancer

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Colon Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Colon Cancer according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cetuximab44 49 1111.6CTNNB1, BRAF
2crcs449.5CTNNB1, BRAF
3geldanamycin44 49 59 1112.4BRAF, CTNNB1
4p002449.3CTNNB1, BRAF
5imatinib44 49 1111.3CTNNB1, BRAF
6paclitaxel44 49 1111.0CTNNB1, AURKA, BRAF
7aspartate449.0CTNNB1, AURKA, BRAF
8threonine448.9CTNNB1, AURKA, BRAF
9estrogen448.7BRAF, AURKA, CTNNB1
10fatty acid448.7BRAF, CTNNB1, MT-CO1
11atp44 289.2MT-CO1, CTNNB1, BRAF

GO Terms for genes affiliated with Colon Cancer

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Products for genes affiliated with Colon Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colon Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet