MCID: CLN016
MIFTS: 66

Colon Cancer malady

Cancer category

Summaries for Colon Cancer

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Colorectal cancer, also known as colon cancer, rectal cancer, or bowel cancer, is a cancer from... more...

MalaCards: Colon Cancer, also known as carcinoma of colon, is related to colorectal cancer and adenoma. An important gene associated with Colon Cancer is AURKA (aurora kinase A), and among its related pathways are DNA Damage and Pathways in cancer. The compounds mononucleotide and o6-methylguanine have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and digestive/alimentary.

Description from OMIM:47 114500

Aliases & Classifications for Colon Cancer

Sources:
8Disease Ontology, 47OMIM, 45Novoseek, 61UMLS, 20GeneTests, 22GTR, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

colon cancer 8 47 45
carcinoma of colon 8 20 22
colon carcinoma 8 45 61
colonic carcinoma 8
colorectal cancer 61


External Ids:

Disease Ontology8 DOID:219, DOID:1520
MeSH35 D003110
NCIt40 C9242, C4910
ICD9CM27 153, 153.9
OMIM47 114500
ICD1025 C18

Related Diseases for Colon Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Colon Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 375)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.1APC, MLH1, MSH6, MSH2
2adenoma31.1APC, MLH1, SLC26A3, MSH6, MSH2, PTPRJ
3familial adenomatous polyposis30.6APC, MLH1, MSH6, MSH2
4familial colorectal cancer30.2APC, MLH1, MSH6, MSH2
5muir-torre syndrome30.1MSH2, MSH6, MLH1
6small intestine cancer29.9MLH1, MSH6
7turcot syndrome29.9APC, MLH1, MSH6
8neurofibromatosis29.9MSH2, MSH6, MLH1
9sigmoid colon cancer10.9
10colorectal cancer 210.8
11colorectal cancer, somatic10.8
12vascular cancer10.8
13colon cancer, advanced10.7
14colorectal cancer 310.7
15colorectal cancer 1110.7
16hypoxia10.6
17ascending colon cancer10.6
18transverse colon cancer10.6
19colorectal cancer 710.6
20colorectal cancer 1010.6
21colorectal cancer 610.5
22colorectal cancer 1210.5
23colorectal cancer 510.5
24colorectal cancer 410.5
25adenocarcinoma10.5
26ulcerative colitis10.4
27colon cancer, somatic10.4
28small bowel adenocarcinoma10.4
29oligodontia-colorectal cancer syndrome10.3
30radiation induced cancer10.3
31somatostatin analog10.3
32crohn's disease10.3
33colon lymphoma10.3
34n syndrome10.3
35thyroid cancer10.3
36tetraploidy10.3
37thyroid lymphoma10.2
38ataxia telangiectasia10.2
39cronkhite-canada syndrome10.2
40rectal prolapse10.2
41splenic abscess10.2
42intussusception10.2
43situs inversus10.2
44attenuated familial adenomatous polyposis10.2
45desmoid tumor10.2
46oral cancer10.2
47ataxia10.2
48colorectal cancer, hereditary nonpolyposis, type 110.2
49bone marrow cancer10.2
50neuroendocrine carcinoma10.2

Graphical network of the top 20 diseases related to Colon Cancer:



Diseases related to colon cancer

Clinical Features for Colon Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114500

Drugs & Therapeutics for Colon Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colon Cancer

Drug clinical trials:

Search ClinicalTrials for Colon Cancer

Search NIH Clinical Center for Colon Cancer

Search CenterWatch for Colon Cancer

Genetic Tests for Colon Cancer

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Colon Cancer:

id Genetic test Affiliating Genes
1 Colon Cancer (apc I1307k Related)20 APC
2 Carcinoma Of Colon22

Anatomical Context for Colon Cancer

Animal Models for Colon Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Colon Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.7PTPRJ, MSH2, MSH6, MLH1, APC, AURKA
2MP:000538111.6SDCCAG8, APC, STARD10, MLH1, SLC26A3, MSH2

Publications for Colon Cancer

Sources:
51PubMed
See all sources

Articles related to Colon Cancer:

(show top 50)    (show all 4727)
idTitleAuthorsYear
1
Obesity, outcomes and quality of care: body mass index increases the risk of wound-related complications in colon cancer surgery. (24139555)
2014
2
A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. (24239863)
2014
3
The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. (22391563)
2013
4
Expression profiling based on graph-clustering approach to determine colon cancer pathway. (24125984)
2013
5
One case of endometrial cancer occurrence: Over 10 years after colon cancer in Lynch family. (24396821)
2013
6
Promoter methylation of the DLCa891 gene and its inhibitory effect on human colon cancer. (23783552)
2013
7
Increased TGF-I+ as a Mechanism of Acquired Resistance to the Anti-EGFR Inhibitor Cetuximab through EGFR-MET Interaction and Activation of MET Signaling in Colon Cancer Cells. (24122793)
2013
8
Targeting IL-11 signaling in colon cancer. (24163267)
2013
9
Knockdown of lymphoid enhancer factor 1 inhibits colon cancer progression in vitro and in vivo. (24098538)
2013
10
STAT3 repressed USP7 expression is crucial for colon cancer development. (22750444)
2012
11
Secreted clusterin in colon tumor cell models and its potential as diagnostic marker for colorectal cancer. (22236192)
2012
12
Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. (21621326)
2011
13
MicroRNA-22 regulates hypoxia signaling in colon cancer cells. (21629773)
2011
14
Construction and identification of CerbB-2 siRNA expression plasmid and its transfer into human colon cancer cell lines HT-29]. (19778814)
2009
15
Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. (19420749)
2009
16
Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of rat colonic crypts. (19465005)
2009
17
Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels. (17936723)
2008
18
Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells. (18566015)
2008
19
Lung cancer producing granulocyte colony-stimulating factor and rapid spreading to peritoneal cavity. (18758311)
2008
20
Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. (18413814)
2008
21
Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide. (18261206)
2008
22
Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. (17404062)
2007
23
The anti-diabetic drug troglitazone sensitizes colon cancer cells to TRAIL-induced apoptosis by down-regulating FLIP]. (18314627)
2007
24
Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer. (17705727)
2007
25
Gender-specific association of the VEGF -2578C > A polymorphism in Korean patients with colon cancer. (17695550)
2007
26
Gastrin 1-6 promotes growth of colon cancer cells through non-CCK receptors. (17126952)
2007
27
Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. (17650425)
2007
28
Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. (16262603)
2006
29
Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. (16373718)
2005
30
Alteration of gene expression in macroscopically normal colonic mucosa from individuals with a family history of sporadic colon cancer. (15746039)
2005
31
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. (15655348)
2005
32
Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. (15142888)
2004
33
Two mismatch repair gene mutations found in a colon cancer patient - which one is pathogenic? (12522549)
2003
34
Therapeutic use of granulocyte and granulocyte-macrophage colony-stimulating factors in febrile neutropenic cancer patients. A systematic review of the literature with meta-analysis. (11904782)
2002
35
Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. (12027200)
2002
36
Soluble Fas antigen in the serum of patients with colon cancer. (11550026)
2001
37
A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer. (11221825)
2001
38
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. (10962573)
2000
39
Enhancement of the anti-tumor activity of a peripheral blood progenitor cell graft by mobilization with interleukin 2 plus granulocyte colony-stimulating factor in patients with advanced breast cancer. (10658681)
2000
40
Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers. (10506115)
1999
41
Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells. (8069864)
1994
42
Effect of granulocyte colony-stimulating factor on chemotherapy-induced neutropenia in children with cancer. (7515635)
1994
43
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. (8178713)
1993
44
Carcinoembryonic antigen mediates in vitro cell aggregation induced by interferon-gamma in a human colon cancer cell line: requirement for active metabolism and intact cytoskeleton. (8364886)
1993
45
Expression of the 40 kD protein in DLD-1 colon cancer cells and the effect of cytokines. (1373349)
1992
46
Expression of gene products of insulin-like-growth-factor II, insulin-like-growth-factor II receptor and colony-stimulating-factor-I receptor in human primary hepatocellular carcinoma and non-cancerous liver tissues]. (1337723)
1992
47
Granulocyte-macrophage colony-stimulating factor (GM-CSF) in the management of cancer. (1810441)
1991
48
Heritable colon cancer: influence of increased calcium concentration on increased in vitro tetraploidy (IVT). (1662764)
1991
49
Granulocyte-macrophage colony stimulating factor (GM-CSF) after high-dose melphalan in patients with advanced colon cancer. (1692472)
1990
50
Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer. (2154329)
1990

Genetic Variations for Colon Cancer

Expression for genes affiliated with Colon Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Colon Cancer

Search GEO for disease gene expression data for Colon Cancer.

Pathways for genes affiliated with Colon Cancer

Sources:
4Cell Signaling Technology, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Colon Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3AURKA, MLH1, MSH6, MSH2
211.3MSH2, MSH6, MLH1, APC
3
Hide members
11.3MSH2, MSH6, MLH1, APC
411.3APC, MLH1, MSH6, MSH2
511.1APC, MLH1, MSH2
611.1MSH2, MSH6, AURKA
7
Hide members
11.1MSH2, MSH6, MLH1
8
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
11.1MSH2, MSH6, MLH1

Compounds for genes affiliated with Colon Cancer

Sources:
45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Colon Cancer according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1mononucleotide4511.6MSH2, MSH6, MLH1, APC
2o6-methylguanine4511.5APC, MLH1, MSH6, MSH2
3crcs4511.5APC, MLH1, MSH6, MSH2
4paraffin4511.4APC, MLH1, MSH6, MSH2
5n-methyl-n-nitrosourea4511.3MSH2, MSH6, MLH1
6mnng4511.3MSH2, MLH1, APC
7biotin45 11 2413.3MLH1, MSH6, MSH2
8threonine4511.2AURKA, APC, MLH1, MSH6, PTPRJ
9sodium bisulfite4511.0MLH1, APC
106 thioguanine4511.0MSH2, MLH1
11adenine45 11 2413.0MSH2, MLH1, APC
125-methylcytosine45 2411.9APC, MLH1
13temozolomide45 1111.9MSH2, MLH1

GO Terms for genes affiliated with Colon Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Colon Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1centrosomeGO:00581311.3SDCCAG8, CEP55, APC, AURKA
2MutSalpha complexGO:03230110.6MSH2, MSH6

Biological processes related to Colon Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1somatic hypermutation of immunoglobulin genesGO:01644611.3MSH2, MSH6, MLH1
2isotype switchingGO:04519011.3MSH2, MSH6, MLH1
3mismatch repairGO:00629811.3MLH1, MSH6, MSH2
4meiotic mismatch repairGO:00071011.0MSH2, MSH6
5positive regulation of helicase activityGO:05109611.0MSH6, MSH2
6maintenance of DNA repeat elementsGO:04357011.0MSH6, MSH2
7somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, MSH2
8intrinsic apoptotic signaling pathway in response to DNA damageGO:00863010.9MSH6, MLH1
9negative regulation of DNA recombinationGO:04591010.8MSH2, MSH6
10determination of adult lifespanGO:00834010.6MSH2, MSH6

Molecular functions related to Colon Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.6MLH1, USHBP1, STARD10, APC, AURKA, SLC26A3
2guanine/thymine mispair bindingGO:03213711.3MSH2, MSH6, MLH1
3protein kinase bindingGO:01990111.3AURKA, APC, MSH2, PTPRJ
4single thymine insertion bindingGO:03214311.1MSH2, MSH6
5oxidized purine DNA bindingGO:03235711.1MSH6, MSH2
6single guanine insertion bindingGO:03214211.1MSH6, MSH2
7four-way junction DNA bindingGO:00040011.1MSH6, MSH2
8MutLalpha complex bindingGO:03240511.0MSH2, MSH6
9mismatched DNA bindingGO:03098311.0MSH2, MSH6
10ATPase activityGO:01688711.0MSH2, MSH6, MLH1
11gamma-catenin bindingGO:04529511.0PTPRJ, APC
12ADP bindingGO:04353110.9MSH2, MSH6

Products for genes affiliated with Colon Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colon Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet