Colon Carcinoma malady

Wikipedia: Colorectal cancer, commonly known as colon cancer or bowel cancer, is a cancer from uncontrolled cell...⁴⁴ more...

MalaCards: Colon Carcinoma, also known as carcinoma of colon (disorder), is related to carcinoma and prostatitis. An important gene associated with Colon Carcinoma is RPSA (ribosomal protein SA), and among its related pathways are Pathways in cancer and MAPK Signaling. The drugs carmustine and diethylstilbestrol diphosphate and the compounds serine and oxygen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, small intestine and colon, and related mouse phenotypes are cellular and homeostasis/metabolism.

Aliases & Descriptions:

colon carcinoma 6 32 43 carcinoma of colon (disorder) 6 carcinoma of colon 6

colonic carcinoma 6 carcinoma 43

Diseases related to colon carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1600)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	127.3	ZNF146, PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIAS1
2	prostatitis	87.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIAS1, PIK3CG
3	leukemia	86.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIAS1, PIK3CG
4	pancreatitis	85.3	ZNF146, PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG
5	colon cancer	84.5	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF4
6	adenocarcinoma	84.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
7	breast carcinoma	81.7	PIK3CA, PIK3R1, PIK3CG, NCL, KIT, KITLG
8	neuronitis	80.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KLF4
9	esophagitis	78.7	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, NCAM1
10	hepatocellular carcinoma	76.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KL, NCAM1
11	gastric cancer	76.6	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF4
12	ovarian cancer	76.2	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCAM1, PDCD4
13	melanoma	76.1	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL
14	lung carcinoma	75.7	PIK3CA, PIK3R1, PIK3CG, NCAM1, GCNT1, SELL
15	thyroiditis	72.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
16	cervicitis	67.7	PIK3CA, PIK3CG, KL, NCL, PDCD4, KIT
17	ovarian carcinoma	67.2	PIK3CA, PIK3CG, PDCD4, REV3L, KIT, VTN
18	adenoma	65.8	PIK3CA, KLF4, NCAM1, PDCD4, KIT, KITLG
19	oral squamous cell carcinoma	65.5	PIK3CA, PDCD4, VTN, SELE, SERPINF1, SERPINE1
20	hypoxia	64.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, PDCD4
21	sarcoma	63.1	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1
22	fibrosis	62.4	PIK3CA, PIK3CG, KL, RETNLB, KIT, KITLG
23	neuroblastoma	62.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
24	hepatitis b	61.8	PIK3CA, PIK3R1, PIK3CG, REV3L, KITLG, KIR3DS1
25	esophageal squamous cell carcinoma	61.2	PIK3CA, NCAM1, KIT, SELE, SERPINE1, VEGFA
26	renal cell carcinoma	61.1	PIK3CA, KIT, SELP, BRAF, VEGFA, RARB
27	arthritis	60.3	PIK3CG, KL, KLF5, KIT, KITLG, KIR3DS1
28	pancreatic carcinoma	59.9	ZNF146, PIK3CA, NCAM1, KITLG, VTN, RBBP8
29	myeloma	59.5	PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1, KIT
30	cervical cancer	59.4	PIK3CA, PIK3CG, NCL, VTN, SERPINF1, SERPINE1
31	cervical carcinoma	59.3	PIK3CA, PIK3CG, KL, KIT, KITLG, VTN
32	myeloid leukemia	59.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KLF5
33	nasopharyngitis	58.8	PIK3CA, PIK3CG, KLF5, KIT, KITLG, BRAF
34	endometrial cancer	56.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDCD4
35	rheumatoid arthritis	56.5	PIK3CG, KL, KLF5, KIT, KITLG, KIR3DS1
36	cholangiocarcinoma	56.5	PIK3CA, PIK3CG, NCAM1, PDCD4, KIT, SELE
37	bladder carcinoma	56.2	PIK3CA, PIK3CG, SELE, BRAF, VEGFA, MYC
38	laryngitis	54.6	PIK3CA, PDCD4, SERPINE1, BRCA1, VEGFA, VCAN
39	cholesterol	54.1	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIAS1, PIK3CG
40	endometrial carcinoma	54.1	PIK3CB, PIK3CA, PIK3CG, KIT, SERPINE1, BRAF
41	osteosarcoma	54.0	PIK3CB, PIK3CA, PIK3CG, PDE1A, REV3L, KIT
42	lymphocytic leukemia	53.5	PIK3CA, PIK3CG, NCAM1, NCL, REV3L, KIT
43	squamous cell carcinoma of the head and neck	53.2	PIK3CA, PIK3CG, VTN, VEGFA, MYC, RARA
44	multiple myeloma	52.9	PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1, KIT
45	retinitis	52.3	PIK3CA, PIK3CG, REV3L, KIT, KITLG, VTN
46	colon adenocarcinoma	52.2	KLF4, NCL, VTN, VIP, BRCA1, VEGFA
47	alzheimer's disease	51.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCAM1, NCL
48	non-small cell lung carcinoma	50.7	NCAM1, BRAF, VEGFA, MYC, BMP2, RAD17
49	laryngeal squamous cell carcinoma	50.6	VEGFA, MYC, RAF1, BLZF1, BIRC5, BCL2
50	esophageal cancer	50.3	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD4

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to colon carcinoma:

²²

MGI Mouse Phenotypes related to colon carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	36.2	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KL, KLF4
2	homeostasis/metabolism phenotype	MP:0005376	35.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL
3	mortality/aging	MP:0010768	34.0	PIK3CB, PIK3CA, PIAS1, KL, KLF4, KLF5
4	growth/size phenotype	MP:0005378	32.9	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KL
5	cardiovascular system phenotype	MP:0005385	30.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL
6	immune system phenotype	MP:0005387	28.3	PIAS1, KL, KLF5, PDCD4, RETNLB, REV3L
7	nervous system phenotype	MP:0003631	27.3	KL, REV3L, KIT, KITLG, SELP, SERPINF1
8	digestive/alimentary phenotype	MP:0005381	23.8	KL, KLF4, KLF5, RETNLB, KIT, KITLG
9	tumorigenesis	MP:0002006	23.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, KLF4, PDCD4
10	hematopoietic system phenotype	MP:0005397	23.4	REV3L, KIT, GCNT1, BTK, BRAF, BRCA1
11	integument phenotype	MP:0010771	22.6	PIK3CG, KL, KLF4, KIT, KITLG, BTK
12	normal phenotype	MP:0002873	21.9	PIK3R1, KLF4, KLF5, VTN, GCNT1, SELE
13	embryogenesis phenotype	MP:0005380	21.6	PIK3CB, PIK3CA, KLF5, REV3L, KIT, RBBP8
14	behavior/neurological phenotype	MP:0005386	21.2	PIK3CA, KL, KLF4, NCAM1, KIT, GCNT1
15	muscle phenotype	MP:0005369	20.7	PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL, KLF5
16	vision/eye phenotype	MP:0005391	20.6	PIK3CA, NCAM1, KIT, KITLG, SELE, SELP
17	skeleton phenotype	MP:0005390	20.5	PIK3CG, KIT, KITLG, BRAF, BRCA1, VEGFA
18	renal/urinary system phenotype	MP:0005367	19.3	KL, PDCD4, KIT, GCNT1, SELP, SELPLG
19	reproductive system phenotype	MP:0005389	18.3	PIK3CA, KLF4, PDCD4, SERPINF1, SEPT4, VIP
20	no phenotypic analysis	MP:0003012	16.0	PIK3R1, VEGFA, VCAM1, MYC, BHLHE40, PARP1
21	liver/biliary system phenotype	MP:0005370	15.1	KIT, PCSK9, VEGFA, MYB, BMP5, RAD50
22	craniofacial phenotype	MP:0005382	15.0	KLF4, REV3L, KIT, KITLG, LPAR1, BMP5
23	limbs/digits/tail phenotype	MP:0005371	14.9	KL, KIT, KITLG, BTK, BRCA1, VEGFA
24	hearing/vestibular/ear phenotype	MP:0005377	14.7	KIT, KITLG, VDR, MYC, BMP2, BMP5
25	endocrine/exocrine gland phenotype	MP:0005379	14.6	KL, KLF4, KLF5, PDCD4, SELL, BRCA1
26	respiratory system phenotype	MP:0005388	13.4	KL, KLF5, SELL, SELP, BRCA1, LPAR2
27	other phenotype	MP:0005395	12.8	KL, RARA, RARB, KDR, LDLR, LAMC2
28	pigmentation phenotype	MP:0001186	12.1	KIT, KITLG, SERPINF1, BRAF, BRCA1, MYC
29	adipose tissue phenotype	MP:0005375	11.9	PIK3CA, PIK3R1, KL, SERPINE1, BRAF, BRCA1

Articles related to colon carcinoma:

(show top 50)    (show all 1003)

id	Title	Authors	Year	Affiliating Genes
1	Effect of L-arginine on human colon carcinoma cell l ine LS174 through NO pathway and the mechanism (20117988)	Huo X.W.... Ma Q.Y.	2010	TP53, BAX, VEGFA
2	Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB. (19583834)	Li C.Y.... Zhang X.S.	2009	PROM1
3	Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. (19302290)	Osumi D.... Taniguchi N.	2009	CDH1, FUT8
4	Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. (16998592)	Nagy K.... PetA!k I.	2006	TNFSF10
5	Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas. (16118352)	Volp K.... Zornig M.	2006	BIRC3, HMGB1
6	Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. (15546879)	Choi W.... Hamilton S.R.	2005	TP53, CASP3, CYCS
7	Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. (16192633)	Lin Q.... Amin H.M.	2005	BCL2, JAK3, STAT3
8	1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. (16007183)	Fernandez-Garcia N.I.... Jimenez B.	2005	CDH1, VEGFA, ID2
9	Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. (15849510)	Bauer T.W.... Ellis L.M.	2005	MET, PLAU, IGF1
10	Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma. (16278666)	Bhagavathula N.... Varani J.	2005	CDH1, MAPK1, MAPK10
11	PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells. (15274299)	Barriere G.... Sturtz F.	2004	PTGS2, GPX4
12	S-Nitrosation regulates the activation of endogenous procaspase-9 in HT-29 human colon carcinoma cells. (14701803)	Kim J.E.... Tannenbaum S.R.	2004	CASP9, NOS2
13	Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype. (15787094)	Li A.... Singh R.K.	2004	CXCL1, CXCR2, CXCL2
14	Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. (12615733)	Krishnamachary B.... Semenza G.L.	2003	HIF1A
15	Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial. (12883662)	Sakamoto J.... Nakazato H.	2003	TYMS
16	Coordinate regulation of IFN consensus sequence-binding protein and caspase-1 in the sensitization of human colon carcinoma cells to Fas-mediated apoptosis by IFN-gamma. (12794166)	Liu K.... Abrams S.I.	2003	CASP1, IFNG, IRF8
17	Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas. (11890990)	Pibouin L.... Goubin G.	2002	C12orf75
18	Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. (12209584)	Magrini R.... Hanski C.	2002	TP53, MLH1
19	Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression. (11205907)	Takebayashi Y.... Pommier Y.	2001	TOP1
20	Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells. (11410863)	Cesaro P.... Isidoro C.	2001	PRKCB, DYT10
21	Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival. (11706074)	Vonlaufen A.... Imhof B.A.	2001	ITGAV
22	Genetic analysis of multiple sporadic colon carcinomas from a single patient. (10855548)	Barnetson R.A.... Schnitzler M.	2000	TGFBR2, BAX, IGF2R
23	Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue. (10219017)	Kojima M.... Tanaka M.	1999	NOS2
24	Molecular cloning of a novel human PAPS synthetase which is differentially expressed in metastatic and non-metastatic colon carcinoma cells. (10399321)	Franzon V.L.... Cleary E.G.	1999	PAPSS1, PAPSS2
25	p53 over-expression and p53 mutations in colon carcinomas: relation to dietary risk factors. (10328215)	Voskuil D.W.... van't Veer P.	1999	TP53
26	Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes. (9485028)	Brossart P.... Brugger W.	1998	ERBB2
27	Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype. (9380022)	Parsels L.A.... Maybaum J.	1997	TP53
28	Phosphorothioated antisense c-myc oligonucleotide inhibits the growth of human colon carcinoma cells. (9494542)	Yu B.W.... Allegra C.A.	1997	MYC
29	Colon carcinoma cell lines stimulate monocytes and lamina propria mononuclear cells to produce IL-10. (9367416)	Kucharzik T.... Stoll R.	1997	TGFB1, IL10
30	Decreased stability of transforming growth factor beta type II receptor mRNA in RER+ human colon carcinoma cells. (9402753)	Jiang W.... Banerji S.S.	1997	TGFBR2
31	Anti-metastatic prostacyclins inhibit the adhesion of colon carcinoma to endothelial cells by blocking E-selectin expression. (8674277)	Daneker G.W.... Wood W.C.	1996	TNF, SELE, VCAM1
32	Cytokeratins 7 and 20 and carcinoembryonic antigen in ovarian and colonic carcinoma. (8729984)	Berezowski K.... Kornstein M.J.	1996	KRT7, KRT20
33	Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue. (8909999)	Hanski C.... Riecken E.O.	1996	FUT3, FUT6, FUT7
34	Modulation of the plasminogen activation system by inflammatory cytokines in human colon carcinoma cells. (8826848)	TrAcn-Thang C.... Sordat B.	1996	PLAU, PLAT
35	Mutations of the transforming growth factor-beta type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. (8952554)	Akiyama Y.... Yuasa Y.	1996	TGFBR2, MLH1
36	Recombinant human interferon alpha-2a increases the a ntitumor activity of 5-fluorouracil on human colon carcinoma xenograft Co-4 wit hout any change in 5-FU pharmacokinetics. (7733626)	Kase S.... Kitajima M.	1995	IFNA2, IFNA1
37	Ca2+ influx induced by store release and cytosolic Ca2+ chelation in Ht29 colonic carcinoma cells. (7478916)	Kerst G.... Greger R.	1995	NTS
38	Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines. (7893368)	Nomoto K.... Weinstein I.B.	1995	PLCG1, PLCB1, PLCD1
39	Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells. (7669730)	Velcich A.... Augenlicht L.	1995	MUC2
40	Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells. (8012988)	Hyuga S.... Shimizu S.	1994	MMP9
41	Human colon carcinoma cells (CaCo-2) synthesize IGF-II and express IGF-I receptors and IGF-II/M6P receptors. (9397946)	Hoeflich A.... Kiess W.	1994	IGF1R, IGF2
42	Autocrine transforming growth factor-beta 1 and beta 2 expression is increased by cell crowding and quiescence in colon carcinoma cells. (8082724)	Sun L.... Brattain M.G.	1994	TGFB1
43	Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines. (7584086)	Sorscher E.J.... Parker W.B.	1994	PNP
44	Gene expression of EGFR, EGF and TGF alpha in human colonic carcinoma cell lines (7867092)	Qu X.... Liu T.	1994	EGFR, EGF, TGFA
45	Detection of gastrin mRNA in fresh human colonic carcinomas by reverse transcription-polymerase chain reaction. (7507679)	Monges G.... Sauvan R.	1993	GAST
46	Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts. (8408644)	Murphy W.J.... Longo D.L.	1993	IL7
47	Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression. (7689422)	Hanski C.... Xing P.X.	1993	MUC1
48	Isolation and characterization of a mitomycin C-resis tant variant of human colon carcinoma HT-29 cells. (7505723)	Lee J.H.... Tsuruo T.	1993	NQO1
49	Expression of a Mr 32,000 laminin-binding protein messenger RNA in human colon carcinoma correlates with disease progression. (2141294)	Mafune K.... Steele G.D.	1990	LGALS3
50	Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. (2835736)	Veillette A.... Rosen N.	1987	LCK

Genes related to colon carcinoma according to GeneCards:

(show top 50)    (show all 725)

id	Symbol	Description	Score	GeneCards Section Context
1	RPSA	ribosomal protein SA	11.1	Publications, Aliases & Descriptions, Summaries
2	C12orf75	chromosome 12 open reading frame 75	11.1	Publications, Aliases & Descriptions, Proteins
3	ST14	suppression of tumorigenicity 14 (colon carcinoma)	11.0	Transcripts, Publications, Orthologs, Aliases & Descriptions (show all 5 sections) Functions
4	FHIT	fragile histidine triad	11.0	Summaries
5	ICT1	immature colon carcinoma transcript 1	11.0	Orthologs, Aliases & Descriptions, Publications, Transcripts (show all 5 sections) Expressions
6	ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	11.0	Orthologs, Aliases & Descriptions, Functions, Transcripts
7	RPS19	ribosomal protein S19	11.0	Summaries, Expressions, Publications
8	DSG2	desmoglein 2	11.0	Summaries
9	PTK7	PTK7 protein tyrosine kinase 7	11.0	Publications, Aliases & Descriptions
10	ST13P1	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 1	11.0	Aliases & Descriptions
11	ST13P17	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 17	11.0	Aliases & Descriptions
12	ST13P11	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 11	11.0	Aliases & Descriptions
13	ST13P16	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 16	11.0	Aliases & Descriptions
14	ST13P15	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 15	11.0	Aliases & Descriptions
15	ST13P14	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 14	11.0	Aliases & Descriptions
16	ST13P13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 13	11.0	Aliases & Descriptions
17	ST13P20	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 20	11.0	Aliases & Descriptions
18	ST13P12	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 12	11.0	Aliases & Descriptions
19	ST13P10	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 10	11.0	Aliases & Descriptions
20	ST13P18	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 18	11.0	Aliases & Descriptions
21	ST13P2	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 2	11.0	Aliases & Descriptions
22	ST13P19	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 19	11.0	Aliases & Descriptions
23	ST13P8	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 8	11.0	Aliases & Descriptions
24	ST13P9	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 9	11.0	Aliases & Descriptions
25	ST13P21	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 21	11.0	Aliases & Descriptions
26	ST13P22	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 22	11.0	Aliases & Descriptions
27	ST13P3	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 3	11.0	Aliases & Descriptions
28	ST13P6	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 6	11.0	Aliases & Descriptions
29	ST13P7	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 7	11.0	Aliases & Descriptions
30	ST13P5	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 5	11.0	Transcripts, Aliases & Descriptions
31	ST13P4	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 4	11.0	Aliases & Descriptions, Transcripts
32	RETNLB	resistin like beta	11.0	Aliases & Descriptions
33	VGLL3	vestigial like 3 (Drosophila)	11.0	Aliases & Descriptions, Publications
34	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0	Publications
35	ICAM2	intercellular adhesion molecule 2	11.0	Publications
36	SELPLG	selectin P ligand	11.0	Publications
37	CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	11.0	Publications
38	TDGF1P3	teratocarcinoma-derived growth factor 1 pseudogene 3	11.0	Publications
39	TDGF1	teratocarcinoma-derived growth factor 1	11.0	Publications
40	FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	11.0	Publications
41	HAS3	hyaluronan synthase 3	11.0	Publications
42	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
43	GUCA2B	guanylate cyclase activator 2B (uroguanylin)	11.0	Publications
44	TFF3	trefoil factor 3 (intestinal)	11.0	Publications
45	SPN	sialophorin	11.0	Publications
46	CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	11.0	Publications
47	FUT4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	11.0	Publications
48	FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	11.0	Publications
49	AREG	amphiregulin	11.0	Publications
50	TMSB4X	thymosin beta 4, X-linked	11.0	Publications

Pathways related to colon carcinoma according to GeneDecks:

(show top 50)    (show all 382)

id	Pathway	Score	Top Affiliating Genes
1	Pathways in cancer20	20.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIAS1, PIK3CG
2	MAPK Signaling36	17.4	PIK3R2, PIK3R1, KIT, KITLG, BRAF, MYC
3	Focal adhesion20	16.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VTN
4	Ras Pathway36	16.0	PIK3R2, PIK3R1, KIT, BRAF, BMP2, BMP5
5	NFAT in Immune Response36	15.6	PIK3R2, PIK3R1, KIT, KITLG, BTK, BMP2
6	Akt Signaling36	15.3	PIK3R1, PIK3CG, KIT, BTK, BMP2, BMP5
7	Renin-Angiotensin Pathway36	14.7	PIK3R2, PIK3R1, KIT, KITLG, VCAM1, BMP2
8	MAPK signaling pathway20	14.6	BRAF, MYC, RAF1, PAK1, JUN, CD14
9	WNT Signaling36	14.4	MYC, BIRC5, CLDN1, FZD4, JUN, CDH3
10	14-3-3 Induced Intracellular Signaling36	14.4	PIK3R2, PIK3R1, KITLG, BMP2, BMP5, RAF1
11	HGF Pathway36	14.3	PIK3R2, PIK3R1, RAF1, PAK1, JUN, CDKN1B
12	Development_EGFR signaling pathway41	14.3	PIK3CB, PIK3CA, PIK3R2, PIK3R1, MYC, RAF1
13	JNK Pathway36	14.3	PIK3R1, KIT, KITLG, BTK, BMP2, BMP5
14	Rap1 Pathway36	14.2	KITLG, BRAF, BMP2, BMP5, BMP6, RAF1
15	eNOS Signaling36	14.2	PIK3R2, PIK3R1, KIT, KITLG, BMP2, BMP5
16	Epithelial Tight Junctions36	14.1	CLDN2, CLDN4, CLDN1, BCAR1, JUN, JUNB
17	Angiogenesis3	14.1	KDR, MST1R, ITGA5, ITGA6, ITGAV, ITGB1
18	STAT3 Pathway36	13.9	BTK, BRAF, MYC, BMP2, BMP5, BMP6
19	Development_Prolactin receptor signaling41	13.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, MYC, RAF1
20	Development Thrombopoietin-regulated cell processes10	13.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, BRAF, MYC
21	Activation of PKC through GPCR36	13.8	PIK3R2, PIK3R1, PDE1A, KIT, KITLG, BMP2
22	TGF-beta Signaling Pathways37	13.6	PIK3CB, PIK3R2, PIK3R1, PIK3CG, BRAF, MYC
23	Influenza A20	13.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, RAF1
24	Osteoclast differentiation20	13.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, BTK
25	Development VEGF-family signaling10	13.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, VTN, RAF1
26	Development_IGF-1 receptor signaling41	13.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, MYC, RAF1
27	VEGF Signaling Pathway34	13.4	VEGFA, RAF1, KDR, ITGAV, ITGB5, FGF2
28	Neurotrophin signaling pathway20	13.3	PIK3CB, PIK3CA, PIK3R2, PIK3CG, BRAF, RAF1
29	ErbB Family Pathway36	13.2	PIK3R2, PIK3R1, BRAF, RAF1, PAK1, JUN
30	Colorectal cancer20	13.1	PIK3CB, PIK3R2, PIK3R1, PIK3CG, BRAF, BAD
31	Bladder cancer20	13.0	BRAF, VEGFA, MYC, RAF1, CDKN1A, CDK4
32	Adhesion3	13.0	NCAM1, CLDN1, CEACAM5, CEACAM1, JUP, CDH3
33	UVA-Induced MAPK Signaling36	12.8	PIK3R2, PIK3R1, BCL2L1, JUN, FOS, MAPK8
34	Cell adhesion ECM remodeling10	12.7	VTN, SERPINE1, VCAN, SDC2, LAMC2, CD44
35	Regulation of eIF4 and p70S6K36	12.7	PIK3R2, PIK3R1, BTK, BMP2, BMP5, BAX
36	14-3-3 Induced Apoptosis36	12.6	PIK3R2, PIK3R1, BID, BCL2, BAD, JUN
37	Development FGFR signaling pathway10	12.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAF1, PAK1
38	Development_FGFR signaling pathway41	12.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAF1, PAK1
39	Cytoskeleton remodeling FAK signaling10	12.5	PIK3CB, PIK3R2, RAF1, PAK1, KDR, BCAR1
40	Development_Ligand-independent activation of ESR1 and ESR241	12.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAF1, IRS1
41	NF-KappaB Family Pathway36	12.2	PIK3R2, PIK3R1, KITLG, BMP2, BMP5, BMP6
42	Development EPO-induced MAPK pathway10	12.0	PIK3CG, KIT, KITLG, BTK, RAF1, PAK1
43	Immune response Role of integrins in NK cells cytotoxicity10	11.9	VCAM1, RAF1, PAK1, ITGAL, ITGAM, ITGB1
44	ErbB2-ErbB3 Heterodimers36	11.8	PIK3R2, PIK3R1, RAF1, BAD, GSK3B, MAP2K2
45	Development_EGFR signaling via small GTPases41	11.8	MYC, RAF1, FOS, MAPK8, MAPK10, MAPK1
46	Toll-like receptor signaling pathway20	11.7	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, JUN
47	HMGB1 Pathway36	11.7	PIK3R2, PIK3R1, JUN, FOS, IL1A, IL1B
48	Immune response_Role of integrins in NK cells cytotoxicity41	11.7	VCAM1, RAF1, PAK1, ITGAL, ITGAM, ITGB1
49	Signal transduction AKT signaling10	11.5	PIK3CB, PIK3R2, PIK3R1, IRS1, GSK3B, HSP90AB1
50	NOD-like receptor signaling pathway20	10.9	BIRC3, XIAP, IL18, IL1B, IL6, IL8

Compounds related to colon carcinoma according to GeneDecks:

(show top 50)    (show all 476)

id	Compound	Score	Top Affiliating Genes
1	serine32	36.4	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF5
2	oxygen32 18	27.7	KITLG, SELPLG, SERPINF1, BRCA1, MYB, BMP2
3	estrogen32	25.3	PIK3CB, PIK3R1, PIAS1, KLF5, NCL, SERPINE1
4	glutamate32	22.7	PIK3CB, PIK3CA, PIK3R1, NCAM1, VTN, SERPINF1
5	butyrate32	22.7	KLF4, KITLG, VDR, MYC, MYB, BMP6
6	matrigel32	21.9	PIK3CA, PIK3R1, PIK3CG, NCAM1, VTN, SELE
7	superoxide32 18	19.6	PIK3CA, PIK3R1, KITLG, SELL, VCAM1, BLZF1
8	agar32	18.5	PIK3CA, PIK3R1, KITLG, BRAF, BRCA1, RARA
9	glycogen32 18	18.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KIT, MYC
10	herbimycin a32 42	17.9	PIK3CG, KITLG, VTN, SELE, SELL, VCAM1
11	rapamycin32 42	17.2	PIK3CG, KIT, KITLG, SELL, BRAF, VEGFA
12	ly29400232	15.7	PIK3CB, PIK3CA, PIK3R1, PIK3CG, VTN, SELE
13	phorbol32	15.5	SELL, MYC, MYB, RAF1, CHGA, LCK
14	ascorbic acid32 18	16.3	PIK3CG, VDR, BMP2, RAF1, CHKA, LDLR
15	irinotecan32 34 9 9	18.3	KIT, BRAF, VEGFA, PARP1, BCL2L1, UMPS
16	ceramide32	15.2	PIK3CA, PIK3R1, BNIP3, RAF1, BID, BCL2L1
17	aspirin32 34 18	16.7	KITLG, VTN, SELE, SELL, SELP, SERPINE1
18	agarose32	14.6	KIT, KITLG, BRCA1, MYC, BLZF1, PARP1
19	hyaluronic acid32 18	15.5	VTN, VCAN, MYC, BMP6, MUC1, B2M
20	suramin32 9 9	16.4	NCAM1, VIP, VEGFA, BMP6, RAF1, KDR
21	daunorubicin32 9 9	16.3	KITLG, MYC, RAF1, BIRC5, BCL2, BCL2L1
22	formaldehyde32 18	15.1	KIT, SELE, SELL, SELP, BLZF1, LGALS3
23	fibrinogen32	14.0	PIK3CB, VTN, BTK, SELE, SELP, SELPLG
24	sulforaphane32	14.0	PIK3CG, PARP1, KEAP1, UGT1A, JUN, CDKN1A
25	rantes32	13.9	KITLG, SELE, SELL, SELP, VIP, VCAM1
26	cd 43732	13.8	MYC, RARA, RARB, BID, PARP1, BCL2
27	tunicamycin32	13.6	PIK3CG, MUC2, P4HB, CFTR, CD4, CD44
28	phospholipid32	13.5	PIK3R1, LPAR1, LPAR2, BLZF1, LGALS9, LDLR
29	sialic acid32	13.4	NCAM1, GCNT1, SELL, SELPLG, LGALS1, MUC2
30	sodium orthovanadate32	13.1	RAF1, BLZF1, MTMR3, JAK2, CDC25C, CDKN3
31	salicylic acid32	13.0	PIK3CG, VDR, MYC, BCL2L1, CFTR, MMP3
32	2-methoxyestradiol32 18	14.0	BID, BCL2, BCL2L1, BAX, CDKN1A, CDK2
33	mannitol32 9 9	14.9	SELP, SERPINE1, VCAM1, B2M, JAK2, CDKN3
34	caffeine32 34 9 18 9	16.8	PIK3R1, VIP, BRCA1, VDR, BMP6, CHEK1
35	vitamin a32 9 18 9	15.7	VDR, MYC, RARA, RARB, RAF1, BLZF1
36	norepinephrine32 9 18 9	15.6	KITLG, SELE, SELL, SELP, VIP, VCAM1
37	dfmo32	12.5	MYC, BIRC3, CDKN1A, CDK2, CDH1, MAPK10
38	c2ceramide32	12.5	PIK3CG, PARP1, BCL2L1, BAX, JUN, IRS1
39	temozolomide32 9 9	14.4	VEGFA, PARP1, CHEK1, MSH2, CDKN1A, CDC25C
40	dbc-amp32	12.4	NCAM1, VIP, BMP6, CDKN1B, CD14, ITGAM
41	betulinic acid32	12.3	BIRC5, PARP1, BCL2, BCL2L1, MCL1, FASLG
42	nadph32 18	13.1	PIK3CA, PAK1, P4HB, ASS1, GLUD1, AKT1
43	z-vad-fmk32 42	13.0	PARP1, BCL2, BCL2L1, BAX, GZMB, MAPK14
44	bapta32	11.9	RAF1, P2RY2, FOS, MAPK3, MAPK14, HSPG2
45	radicicol32 42 9 9	14.8	PIK3CG, VEGFA, RAF1, JUN, MAPK3, MAPK10
46	2-deoxyglucose32	11.5	PIK3R1, PIK3CG, BAIAP2L1, FOS, IRS1, INS
47	losartan32 34 9 9	14.5	SELE, SELP, SERPINE1, VCAM1, BMP6, LEP
48	alpha tocopherol32	11.2	VCAM1, RARB, LEP, CHKA, LDLR, CDKN3
49	pentoxifylline32 9 9	12.2	SELL, SELP, VCAM1, BMP2, BMP6, CD14
50	ccl332	10.0	MMP9, IL10, IL13, IL15, IL18, IL1A

Cellular components related to colon carcinoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	29.1	ZNF146, PIK3CB, PIAS1, KLF5, NCL, PDCD4
2	cytoplasm	GO:005737	27.7	ZNF146, PIK3CG, PDCD4, KIT, KITLG, PCSK9
3	cytosol	GO:005829	26.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDCD4
4	plasma membrane	GO:005886	26.2	PIK3R1, PIK3CG, KL, NCAM1, KIT, KITLG
5	integral to plasma membrane	GO:005887	19.4	KL, KIR3DS1, SELL, SELP, SELPLG, LPAR1
6	nucleoplasm	GO:005654	17.3	PIAS1, BRCA1, VDR, BNIP3, MYC, RARA
7	extracellular region	GO:005576	16.9	KL, NCAM1, RETNLB, KITLG, VTN, SERPINF1
8	cell surface	GO:009986	15.5	NCAM1, PCSK9, VEGFA, LPAR1, LPAR2, VCAM1
9	extracellular space	GO:005615	15.1	KL, KIT, KITLG, VTN, PCSK9, GCNT1
10	external side of plasma membrane	GO:009897	12.3	NCAM1, KIT, SELL, SELP, VCAM1, KDR
11	membrane raft	GO:045121	12.2	BTK, SELE, LCK, FURIN, JAK2, CD14
12	platelet alpha granule lumen	GO:031093	11.0	SERPINE1, VEGFA, FN1, FIGF, APP, IGF1

Biological processes related to colon carcinoma according to GeneDecks:

(show top 50)    (show all 67)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	18.7	PIK3CB, PDE1A, KIT, KITLG, VDR, RARA
2	small molecule metabolic process	GO:044281	18.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VCAN
3	apoptotic process	GO:006915	17.9	PDCD4, PCSK9, BTK, SEPT4, BRCA1, BNIP3
4	blood coagulation	GO:007596	17.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDE1A
5	positive regulation of cell proliferation	GO:008284	16.4	KLF5, KIT, VIP, VEGFA, MYC, RARA
6	response to drug	GO:042493	16.4	MYC, BCL2, LGALS1, MVP, LCK, BAG1
7	cell adhesion	GO:007155	16.1	NCAM1, KITLG, VTN, SELL, SELP, SELPLG
8	virus-host interaction	GO:019048	16.0	PIK3R1, VCAM1, BNIP3, USP7, CLDN1, KDR
9	cell proliferation	GO:008283	15.1	RETNLB, KITLG, SERPINF1, RAF1, BLZF1, BCAR1
10	positive regulation of transcription from RNA polymerase II promoter	GO:045944	15.0	KLF4, SERPINE1, BRCA1, VEGFA, VDR, MYC
11	negative regulation of transcription from RNA polymerase II promoter	GO:000122	14.8	KLF4, RBBP8, VDR, MYC, MYB, BMP2
12	nerve growth factor receptor signaling pathway	GO:048011	14.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PDE1A, BRAF
13	angiogenesis	GO:001525	14.2	PIK3CA, PIK3CG, KLF5, NCL, SERPINE1, VEGFA
14	epidermal growth factor receptor signaling pathway	GO:007173	14.1	PIK3CA, PIK3R1, PDE1A, RAF1, BCAR1, BAD
15	protein phosphorylation	GO:006468	14.0	BTK, BRAF, RARA, RAF1, BIRC5, PAK1
16	leukocyte migration	GO:050900	14.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELL, SELP
17	negative regulation of cell proliferation	GO:008285	14.0	KLF4, VDR, BMP2, BMP5, RARB, RAF1
18	negative regulation of apoptotic process	GO:043066	13.8	PIK3CG, SERPINE1, BRAF, VEGFA, MYC, BMP5
19	positive regulation of transcription, DNA-dependent	GO:045893	13.7	PIAS1, KLF4, KLF5, BRCA1, MYC, MYB
20	platelet activation	GO:030168	13.7	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, SELP
21	positive regulation of cell migration	GO:030335	13.6	VEGFA, BMP2, KDR, BCAR1, FURIN, JAK2
22	induction of apoptosis by intracellular signals	GO:008629	13.4	BNIP3, MYC, BID, BCL2, BCL2L1, BCL2L11
23	fibroblast growth factor receptor signaling pathway	GO:008543	13.4	PIK3CA, PIK3R1, KL, PDE1A, BRAF, RAF1
24	response to organic cyclic compound	GO:014070	13.2	SELP, MSH2, JUN, JUNB, CDKN1A, CDK1
25	transforming growth factor beta receptor signaling pathway	GO:007179	13.2	SERPINE1, MYC, PARP1, FURIN, FUT8, JUN
26	innate immune response	GO:045087	13.2	PIK3CG, BTK, BCL2, BCL2L1, LGALS3, LCN2
27	anti-apoptosis	GO:006916	13.1	PIK3CA, BRAF, BNIP3, BIRC3, BIRC5, BCL2
28	cell migration	GO:016477	12.9	PIK3CB, BCAR1, CEACAM1, FUT8, JUP, CDK1
29	aging	GO:007568	12.8	KL, SERPINF1, VDR, VCAM1, P2RY2, FURIN
30	chemotaxis	GO:006935	12.6	PIK3CB, FOSL1, FGF2, FER, IL4, MAPK14
31	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	12.5	MYC, BCL2L11, LCK, BAD, BAX, JAK2
32	integrin-mediated signaling pathway	GO:007229	12.5	BCAR1, CEACAM1, FUT8, ITGA1, ITGA2, ITGA3
33	activation of pro-apoptotic gene products	GO:008633	12.4	MYC, BID, BCL2, BCL2L11, BAD, BAX
34	response to hypoxia	GO:001666	12.3	VEGFA, VCAM1, BNIP3, BMP2, RAF1, PAK1
35	response to estradiol stimulus	GO:032355	12.2	VDR, RARA, BID, MMP9, ASS1, IL1B
36	immune response	GO:006955	12.2	KIR3DS1, VTN, BMP6, ZEB1, MR1, CD86
37	activation of MAPK activity	GO:000187	12.0	PIK3CB, KIT, LPAR1, LPAR2, CDK1, ITGA1
38	cellular response to mechanical stimulus	GO:071260	12.0	BNIP3, CHEK1, BAD, ITGB1, IL13, IL18
39	positive regulation of protein phosphorylation	GO:001934	11.7	VEGFA, BMP2, IL1B, ENG, MAPK3, CCND2
40	positive regulation of apoptotic process	GO:043065	11.6	SEPT4, LPAR1, BMP2, RARB, BID, BCL2L11
41	inflammatory response	GO:006954	11.5	PIK3CG, KIT, SELE, SELP, BMP2, BMP6
42	response to mechanical stimulus	GO:009612	11.5	BMP2, JUN, JUNB, MMP9, FOSL1, ANGPT2
43	platelet degranulation	GO:002576	11.5	SELP, SERPINE1, VEGFA, CD63, CD9, FN1
44	cell-cell signaling	GO:007267	11.4	BMP2, CEACAM6, CD86, CD80, ITGB2, INS
45	MAPK cascade	GO:000165	11.4	MYC, RAF1, PAK1, CDK1, INS, FGFR1
46	wound healing	GO:042060	11.4	RAF1, PAK1, SDC2, P2RY2, INS, FGF2
47	activation of MAPKK activity	GO:000186	11.1	RAF1, JAK2, MAP2K2, F2R, NRAS, PLCG1
48	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.1	KITLG, VTN, VEGFA, JAK2, CD4, CD80
49	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.0	KIT, SELP, KDR, JAK2, INS, FGFR1
50	positive regulation of MAPK cascade	GO:043410	10.4	KIT, LPAR1, LPAR2, KDR, LEP, ITGB1

Molecular functions related to colon carcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	39.4	FADD, IL1A, IL15, IL13RA1, IL13, IL12B
2	ATP binding	GO:005524	19.1	RNASEL, HSPD1, HSPA9, HSPA8, HSPA4, HSPH1
3	protein homodimerization activity	GO:042803	15.2	SYNE1, PVRL2, TCF3, DPYD, DPP4, TGFB2
4	protein heterodimerization activity	GO:046982	14.3	P4HB, BRAF, VEGFA, BNIP3, BAX, BAD
5	protein kinase binding	GO:019901	14.1	ADRA2A, EEF1A1, NPM1, PRKCE, STAT3, TCF7L2
6	receptor binding	GO:005102	13.8	ITGB5, ITGB4, ITGB2, JAK2, RARA, BMP2
7	identical protein binding	GO:042802	12.9	TP53, ERBB2, ESR1, AKT1, GLUD1, CASP8
8	enzyme binding	GO:019899	12.8	CYP3A4, MST1R, MSH2, CFTR, YES1, BIRC5
9	protein tyrosine kinase activity	GO:004713	12.4	EPHB2, MAP2K2, FER, MET, FGR, FGFR2
10	integrin binding	GO:005178	12.1	ERBB2IP, CALR, ICAM3, ICAM2, SRC, COL3A1
11	growth factor activity	GO:008083	11.8	CXCL12, CXCL1, TDGF1P3, TDGF1, TFF1, TGFB3
12	transcription regulatory region DNA binding	GO:044212	11.1	NFKB1, NFATC2, NFATC1, SMAD4, PPARG, HIF1A
13	cytokine activity	GO:005125	10.7	IL15, IL13, IL12B, IL10, FGF2, BMP6