MCID: CLN019
MIFTS: 44

Colonic Disease malady

Gastrointestinal diseases category

Aliases & Classifications for Colonic Disease

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Colonic Disease, Aliases & Descriptions:

Name: Colonic Disease 9
Colonic Diseases 43 32 60
 
Diverticular Disease of Colon 9 60
Colon Disorder 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:5353
SNOMED-CT55 128524007
MeSH33 D003108

Summaries for Colonic Disease

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MedlinePlus:32 Your colon, also known as the large intestine, is part of your digestive system. it's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. many disorders affect the colon's ability to work properly. some of these include colorectal cancer colonic polyps - extra tissue growing in the colon that can become cancerous ulcerative colitis - ulcers of the colon and rectum diverticulitis - inflammation or infection of pouches in the colon irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms treatment for colonic diseases varies greatly depending on the disease and its severity. treatment may involve diet, medicines and in some cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Colonic Disease, also known as colonic diseases, is related to functional colonic disease and ulcerative colitis. An important gene associated with Colonic Disease is CTSD (cathepsin D), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Immune response MIF mediated glucocorticoid regulation. The drugs scopolamine and scopolamine hydrobromide and the compounds ketorolac and piroxicam have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and small intestine, and related mouse phenotypes are digestive/alimentary and adipose tissue.

Related Diseases for Colonic Disease

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Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1functional colonic disease30.7MLNR, HTR4
2ulcerative colitis30.0NOD2, NOS2, HSPA4
3colitis30.0PTGS2, NOS2, NOD2
4ischemia29.7HSPA4, VTN, NOS2, CTSD
5inflammatory bowel disease29.5HSPA4, PTGS2, NOS2, NOD2
6collagenous colitis10.5NOS2
7breast cancer10.3NOS2, CTSD
8gastroparesis10.3HTR4, MLNR
9focal segmental glomerulosclerosis10.3VTN, NOS2
10li-fraumeni syndrome10.2CTSD, ADAMTSL1
11vitreoretinopathy, neovascular inflammatory10.2ADAMTSL1, VTN
12peptic ulcer disease10.2PTGS2, CTSD
13gastrointestinal system disease10.2PTGS2, NOS2
14microvascular complications of diabetes 110.2ADAMTSL1, VTN
15plasmodium falciparum malaria10.2NOS2, ADAMTSL1
16malaria10.2HSPA4, ADAMTSL1
17liver cirrhosis10.1CTSD, VTN, HSPA4
18breast ductal carcinoma10.1EGFR, CTSD
19adenosquamous carcinoma10.1EGFR, CTSD
20sarcoidosis 110.1NOD2, VTN, HSPA4
21glomerulonephritis10.1NOS2, VTN, ADAMTSL1
22interstitial lung disease10.1VTN, EGFR
23hyperglycemia10.1ADAMTSL1, VTN, NOS2
24laryngeal carcinoma10.1CTSD, EGFR
25tuberculosis10.1CTSD, NOD2, HSPA4
26mucoepidermoid carcinoma10.1NOS2, EGFR
27factor v leiden thrombophilia10.0HSPA4, ADAMTSL1, CTSD
28coronary artery disease10.0HSPA4, ADAMTSL1, VTN
29microvascular complications of diabetes 510.0NOS2, VTN
30laryngeal squamous cell carcinoma10.0EGFR, CTSD
31vascular disease10.0HSPA4, PTGS2, NOS2
32primary hyperoxaluria10.0NOS2, VTN, ADAMTSL1
33sclerosing cholangitis10.0
34cholangitis10.0
35brain disease10.0HSPA4, PTGS2
36congenital heart disease9.9HSPA4, ADAMTSL1, NOS2
37asthma9.9NOD2, NOS2, VTN, HSPA4
38osteosarcoma, somatic9.9HSPA4, ADAMTSL1, VTN
39bladder cancer, somatic9.9PTGS2, EGFR
40leukemia9.9CTSD, ADAMTSL1, HSPA4
41transitional cell carcinoma9.9PTGS2, EGFR, CTSD
42diabetes mellitus, insulin-dependent9.9VTN, ADAMTSL1, HSPA4
43cervical cancer, somatic9.8CTSD, EGFR, PTGS2
44stomach cancer9.8PTGS2, EGFR, CTSD
45alzheimer disease9.8CTSD, NOS2, ADAMTSL1, PTGS2
46cystic fibrosis9.8
47epidermolysis bullosa dystrophica9.8
48hepatitis9.8
49portal hypertension9.8
50merkel cell carcinoma9.8

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to colonic disease

Symptoms for Colonic Disease

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Drugs & Therapeutics for Colonic Disease

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Drug clinical trials:

Search ClinicalTrials for Colonic Disease

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Colonic Disease

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Anatomical Context for Colonic Disease

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MalaCards organs/tissues related to Colonic Disease:

31
Colon, Kidney, Small intestine, Liver, Skin

Animal Models for Colonic Disease or affiliated genes

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MGI Mouse Phenotypes related to Colonic Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8PTGS2, NOS2, NOD2, EGFR, CTSD
2MP:00053758.7PTGS2, HTR4, NOS2, EGFR
3MP:00053978.4PTGS2, VTN, NOS2, NOD2, EGFR, CTSD
4MP:00053798.1HSPA4, PTGS2, NOS2, EGFR, CTSD
5MP:00053788.0CTSD, EGFR, NOD2, NOS2, HTR4, PTGS2
6MP:00053767.8CTSD, EGFR, NOD2, NOS2, VTN, HTR4
7MP:00053847.7HSPA4, PTGS2, NOS2, NOD2, EGFR, CTSD
8MP:00107687.3HSPA4, PTGS2, HTR4, NOS2, NOD2, EGFR
9MP:00036317.2HSPA4, PTGS2, HTR4, NOS2, EGFR, CTSD

Publications for Colonic Disease

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Articles related to Colonic Disease:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables. (25847139)
2015
2
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. (22427959)
2012
3
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. (21825842)
2011
4
Colonic perforation during barium enema in a patient without known colonic disease: a case report. (19918538)
2009
5
Acute colonic disease: how to image in emergency. (17174054)
2007
6
Death from colonic disease in epidermolysis bullosa dystrophica. (16480504)
2006
7
Colonic perforation at CT colonography in a patient without known colonic disease. (16357389)
2006
8
Cerebrospinal fluid polyamine levels in patients with colonic disease. (12567356)
2003
9
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. (16378294)
2002
10
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. (11913411)
2002
11
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. (11595480)
2001
12
Investigation of colonic disease. (11103279)
2000
13
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. (9923929)
1999
14
Psoas abscesses complicating colonic disease: imaging and therapy. (10645182)
1999
15
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. (9600375)
1998
16
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. (9443117)
1998
17
Psoas abscesses complicating colonic disease: imaging and therapy. (10209409)
1998
18
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. (9150951)
1997
19
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. (9412955)
1997
20
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. (9106695)
1997
21
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. (8942726)
1996
22
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. (8587011)
1995
23
Glycosylation patterns of mucins in colonic disease. (8654850)
1995
24
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. (8099272)
1993
25
The antegrade colonogram: extending the small bowel follow through for children suspected of having colonic disease. (1491931)
1992
26
Schistosomal colonic disease. (2110925)
1990
27
A morphometric study of the canine colon: comparison of control dogs and cases of colonic disease. (2249180)
1990
28
A new model for inflammatory colonic disease induced by capsaicin in rats. (2711937)
1989
29
Size of flour particles and its relation to glycaemia, insulinaemia, and colonic disease. (2503150)
1989
30
Human skin fibroblast in vitro tetraploidy. Flow cytometric DNA assay used to confirm metaphase assay in patients with various colonic diseases. (2752376)
1989
31
Anorectal and colonic disease and the immunocompromised host. (3063471)
1988
32
Should colonoscopy be the first investigation for colonic disease? (3126910)
1988
33
99mTc-sucralfate scintigraphy and colonic disease. (3117238)
1987
34
Colonoscopy or barium enema as initial investigation of colonic disease. (2887839)
1987
35
Combined use of double- and single-contrast barium enema in the evaluation of suspected colonic disease. (6468861)
1984
36
Colonic disease in patients receiving hemodialysis. (7059250)
1982
37
Mucosal microhernias in the nonhuman primate colon: their role in the pathogenesis of colonic disease. (6815871)
1982
38
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6796184)
1981
39
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6794824)
1981
40
Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease. (101423)
1978
41
High-fiber diets and colonic disease. (584140)
1977
42
Isolated small bowel obstruction as the presenting feature of colonic disease. (880024)
1977
43
Editorial: Colonoscopy and colonic disease. (1263916)
1976
44
Letter: Peripheral lymphocyte counts in colonic disease. (4136971)
1974
45
Fiberoptic colonoscopy in the management of colonic disease. (4543591)
1974
46
Use of fibreoptic colonoscopy for investigating rectal and colonic disease. (4539316)
1972
47
Diet and colonic disease. (4554581)
1972
48
The radiology corner. Ischemic colonic disease associated with carcinoma of the colon. (5098216)
1971
49
PLAIN ABDOMINAL FILMS IN COLONIC DISEASE. (14214791)
1964
50
THE CONSIDERATION OF RECTAL AND COLONIC DISEASE IN LIFE INSURANCE EXAMINATIONS. (18737136)
1916

Variations for Colonic Disease

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Expression for genes affiliated with Colonic Disease

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Search GEO for disease gene expression data for Colonic Disease.

Pathways for genes affiliated with Colonic Disease

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Pathways related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTGS2, NOS2
29.7NOS2, PTGS2
39.6EGFR, NOS2
49.5NOS2, NOD2, CTSD
5
Show member pathways
9.3NOD2, NOS2, PTGS2
6
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.3EGFR, VTN, PTGS2
7
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.3EGFR, VTN, PTGS2
8
Show member pathways
9.3HSPA4, NOS2
99.2EGFR, NOS2, PTGS2
109.0EGFR, NOS2, HTR4
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.9EGFR, NOD2, NOS2, PTGS2

Compounds for genes affiliated with Colonic Disease

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Compounds related to Colonic Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ketorolac43 1211.1PTGS2, NOS2
2piroxicam43 1211.0EGFR
3mafp4310.0NOS2, PTGS2
4grgds439.9VTN, ADAMTSL1
5silymarin439.7PTGS2, NOS2, EGFR
6rebamipide439.6NOS2, HSPA4
7tirofiban43 1210.6VTN, ADAMTSL1
8celecoxib43 59 28 49 24 1214.6PTGS2, NOS2, EGFR
9hyaluronic acid43 2410.5ADAMTSL1, VTN, CTSD
10egcg439.5EGFR, NOS2, PTGS2
11mannose439.5CTSD, NOD2, ADAMTSL1
12chloroquine43 2 49 28 1213.4HSPA4, VTN, CTSD
13c2ceramide439.4HSPA4, NOS2, CTSD
14nocodazole43 1210.4HSPA4, VTN, CTSD
15cyclopentenone439.3HSPA4, PTGS2, NOS2
16cisplatin43 49 59 1212.3CTSD, EGFR, VTN, PTGS2
17prostacyclin439.3PTGS2, ADAMTSL1, VTN, NOS2
1815-deoxy-delta-12,14-prostaglandin j2439.3NOS2, PTGS2, HSPA4
19resveratrol43 59 24 1212.2HSPA4, PTGS2, NOS2
20gemcitabine43 49 1211.1HSPA4, PTGS2, EGFR
21gf 109203x43 5910.1HSPA4, PTGS2, EGFR
22pge2439.0PTGS2, VTN, NOS2, EGFR, CTSD
23mg 13243 5910.0HSPA4, NOS2, EGFR
24cisapride43 28 1211.0HTR4, MLNR
25tamoxifen43 49 28 1212.0CTSD, EGFR, VTN, HSPA4
26latex438.9HSPA4, ADAMTSL1, VTN, CTSD
27doxorubicin43 49 1210.9CTSD, EGFR, NOS2, HSPA4
28pd 98,059438.8EGFR, VTN, PTGS2, HSPA4
29n acetylcysteine438.8HSPA4, PTGS2, NOS2, EGFR
30sb 20358043 599.8HSPA4, PTGS2, NOS2, EGFR
31aspirin43 49 28 2411.8VTN, ADAMTSL1, PTGS2, HSPA4
32prostaglandin438.8ADAMTSL1, PTGS2, HSPA4
33aspartate438.8HSPA4, ADAMTSL1, VTN, CTSD
34heparin43 28 24 1211.8HSPA4, ADAMTSL1, VTN, CTSD
35estrogen438.8PTGS2, ADAMTSL1, NOS2, EGFR, CTSD
36nitric oxide43 24 1210.6HSPA4, PTGS2, NOS2, NOD2, CTSD
37h2o2438.6HSPA4, ADAMTSL1, NOS2, CTSD
38genistein43 28 59 2 24 1213.5HSPA4, PTGS2, NOS2, EGFR, CTSD
39herbimycin a43 599.5HSPA4, PTGS2, VTN, NOS2, EGFR
40curcumin438.5EGFR, NOS2, VTN, PTGS2, HSPA4
41ly294002438.5EGFR, NOS2, VTN, PTGS2, HSPA4
42dexamethasone43 49 28 1211.4NOS2, VTN, ADAMTSL1, PTGS2, HSPA4
43glutamate438.4HSPA4, HTR4, VTN, NOS2, CTSD
44cholesterol43 28 24 1211.4HSPA4, ADAMTSL1, VTN, CTSD
45retinoic acid43 249.4HSPA4, ADAMTSL1, VTN, EGFR, CTSD
46calcium43 49 24 1211.3MLNR, ADAMTSL1, VTN, NOS2, NOD2, CTSD
47oxygen43 249.1HSPA4, PTGS2, ADAMTSL1, NOS2, NOD2, CTSD
48serine438.1CTSD, EGFR, NOD2, VTN, ADAMTSL1, HSPA4
49cycloheximide437.7CTSD, HSPA4, PTGS2, ADAMTSL1, VTN, NOS2
50vegf437.7HSPA4, PTGS2, ADAMTSL1, VTN, NOS2, EGFR

GO Terms for genes affiliated with Colonic Disease

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Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:000222710.0NOD2, NOS2
2positive regulation of synaptic transmission, glutamatergicGO:00519689.8EGFR, PTGS2
3negative regulation of protein catabolic processGO:00421779.8EGFR, NOS2
4positive regulation of vasoconstrictionGO:00459079.8PTGS2, EGFR
5positive regulation of vasodilationGO:00459099.8EGFR, NOS2
6positive regulation of nitric oxide biosynthetic processGO:00454299.7PTGS2, EGFR
7regulation of inflammatory responseGO:00507279.6NOD2, PTGS2
8positive regulation of smooth muscle cell proliferationGO:00486619.6EGFR, PTGS2
9cellular response to mechanical stimulusGO:00712609.6EGFR, PTGS2
10positive regulation of epithelial cell proliferationGO:00506799.4EGFR, NOD2

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.3EGFR, NOD2, PTGS2

Products for genes affiliated with Colonic Disease

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Sources for Colonic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet