MCID: CLN019
MIFTS: 54

Colonic Disease malady

Gastrointestinal diseases category

Summaries for Colonic Disease

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33MedlinePlus, 3CDC, 32MalaCards
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MedlinePlus:33 Your colon, also known as the large intestine, is part of your digestive system. it's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. many disorders affect the colon's ability to work properly. some of these include colorectal cancer colonic polyps - extra tissue growing in the colon that can become cancerous ulcerative colitis - ulcers of the colon and rectum diverticulitis - inflammation or infection of pouches in the colon irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms treatment for colonic diseases varies greatly depending on the disease and its severity. treatment may involve diet, medicines and in some cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Colonic Disease, also known as colonic diseases, is related to functional colonic disease and hypertension. An important gene associated with Colonic Disease is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Development Ligand-independent activation of ESR1 and ESR2 and Leishmaniasis. The drugs scopolamine and scopolamine hydrobromide and the compounds glutamate and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and t cells, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

CDC:3 Of cancers affecting both men and women, colorectal cancer (cancer of the colon and rectum) is the second leading cancer killer in the United States, but it doesn't have to be. Screening can find precancerous polyps—abnormal growths in the colon or rectum—so they can be removed before turning into cancer. Screening also helps find colorectal cancer at an early stage, when treatment often leads to a cure.

Aliases & Classifications for Colonic Disease

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colonic disease 8
colonic diseases 44 33 60
diverticular disease of colon 8
colon disorder 8


External Ids:

Disease Ontology8 DOID:5353
SNOMED-CT56 128524007
MeSH34 D003108

Related Diseases for Colonic Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Colonic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1functional colonic disease35.1MLNR, HTR4
2hypertension29.7F5
3familial adenomatous polyposis29.7PTGS2
4ischemia29.7VTN, NOS2, CTSD, HSPA4
5melanoma29.7ADAMTSL1, VTN, PLAU, HSPA4
6inflammatory bowel disease29.7PTGS2, NOD2, NOS2, F5, HSPA4
7colon cancer29.7CTSD, EGFR, PLAU, NOS2, PTGS2, ADAMTSL1
8dyspepsia13.3MLNR
9gastroparesis13.3HTR4, MLNR
10constipation13.3HTR4
11ileus13.3MLNR
12rectal disease10.1
13dermatitis10.0NOD2
14pouchitis10.0NOD2
15meningioma10.0CTSD
16atopy10.0NOD2
17sarcoma10.0HSPA4
18coronary heart disease10.0HSPA4
19crohn's disease10.0NOD2
20arthropathy10.0NOD2
21leishmaniasis10.0HSPA4
22ductal carcinoma in situ10.0EGFR
23dementia10.0HSPA4
24kidney cancer10.0EGFR
25lupus erythematosus10.0F5
26pemphigus10.0PLAU
27influenza10.0HSPA4
28protein c deficiency10.0F5
29hepatitis b10.0HSPA4
30dilated cardiomyopathy10.0CTSD
31hellp syndrome10.0F5
32psoriasis10.0VTN, NOD2
33biliary tract neoplasm10.0EGFR
34fibrosarcoma10.0VTN, PLAU
35cholangiocarcinoma10.0PTGS2
36collagenous colitis10.0NOS2
37factor xii deficiency10.0F5
38pneumonia10.0VTN, HSPA4
39ependymoma10.0EGFR
40multiple sclerosis10.0NOS2, VTN
41lupus nephritis10.0VTN
42vasculitis10.0ADAMTSL1
43amyotrophic lateral sclerosis10.0ADAMTSL1
44laryngeal squamous cell carcinoma10.0CTSD, EGFR
45oligodendroglioma10.0EGFR
46diabetic retinopathy10.0NOS2, VTN
47alzheimer disease type 210.0PLAU, CTSD
48colon adenocarcinoma10.0PTGS2, PLAU
49stroke, ischemic10.0F5, HSPA4
50sarcoidosis10.0HSPA4, NOD2, VTN

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to colonic disease

Clinical Features for Colonic Disease

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Drugs & Therapeutics for Colonic Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Colonic Disease

Drug clinical trials:

Search ClinicalTrials for Colonic Disease

Search NIH Clinical Center for Colonic Disease

Search CenterWatch for Colonic Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Colonic Disease

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Anatomical Context for Colonic Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Colonic Disease:

32
Colon, Kidney, T cells, Liver, Small intestine, Skin, Endothelial, Smooth muscle, Lung, Lymph node, Bone, Testes, B cells, Breast, Heart, Thymus, Bone marrow, Prostate

Animal Models for Colonic Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Colonic Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.3PLAU
2MP:00053769.4CTSD, F5, NOD2, VTN
3MP:00053799.0CTSD, HSPA4
4MP:00053708.4NOS2, PLAU, F5, EGFR, PTGS2
5MP:00053818.4EGFR, CTSD, PLAU, NOS2, NOD2, PTGS2
6MP:00053977.8VTN, PTGS2, NOD2, PLAU, EGFR, CTSD
7MP:00053787.8F5, PLAU, PTGS2, NOS2, CTSD, NOD2
8MP:00036317.3PTGS2, NOS2, PLAU, F5, EGFR, CTSD
9MP:00107687.0CTSD, HSPA4, NOD2, NOS2, PLAU, F5

Publications for Colonic Disease

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Sources:
50PubMed
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Articles related to Colonic Disease:

(show top 50)    (show all 430)
idTitleAuthorsYear
1
Altered colonic mucosal availability of n-3 and n-6 polyunsaturated fatty acids in ulcerative colitis and the relationship to disease activity. (23619007)
2014
2
Comparison between 1.5 and 3.0 Tesla magnetic resonance enterography for the assessment of disease activity and complications in ileo-colonic Crohn's disease. (23903867)
2013
3
Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis. (23468882)
2013
4
Celiac disease presenting as acute colonic pseudo-obstruction. (22919868)
2012
5
Ileal neuroendocrine carcinoma following restorative proctocolectomy for colonic adenocarcinoma in Crohn's disease. (20532536)
2011
6
Proteomic analysis of differentially expressed proteins between stenotic and normal colon segment tissues derived from patients with Hirschsprung's disease. (21327720)
2011
7
High-grade neuroendocrine carcinoma of the colon, long-term survival in advanced disease. (20839076)
2011
8
Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. (20848536)
2011
9
Recurrent retroperitoneal abscess due to perforated colonic diverticulitis in a patient with polycystic kidney disease. (19299224)
2009
10
TGF-beta1 and IGF-1 production and recurrence of Crohn's disease after ileo-colonic resection. (19027918)
2009
11
Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease? (18565233)
2008
12
Rosai-Dorfman disease of the colon. (18291397)
2008
13
Are there any functional differences of nitric oxide between the transitional segment in Hirschsprung's disease and the diseased colon in hypoganglionosis? (18795669)
2008
14
Surveillance of healthy cats and cats with inflammatory skin disease for colonization of the skin by methicillin-resistant coagulase-positive staphylococci and Staphylococcus schleiferi ssp. schleiferi. (17610491)
2007
15
Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases. (17230539)
2007
16
Primary laparoscopic endorectal colon pull-through for Hirschsprung's disease: early results of 61 cases. (16877219)
2006
17
Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? (16428192)
2006
18
VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. (16293653)
2006
19
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. (16110022)
2005
20
Activation antigens on colonic T cells in inflammatory bowel disease: effects of IL-10. (15762887)
2005
21
Indications and technique of colon and jejunal interpositions for esophageal disease. (15927647)
2005
22
Hirschsprung's disease complicating colonic atresia. (15163878)
2004
23
Staphylococci in colonization and disease: prospective targets for drugs and vaccines. (15451502)
2004
24
Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. (12594843)
2003
25
Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats. (12811818)
2003
26
Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. (12671885)
2003
27
Laparoscopy-assisted suction colonic biopsy and intraoperative rapid acetylcholinesterase staining during transanal pull-through for Hirschsprung's disease. (12483623)
2002
28
Distribution of carbon monoxide-producing neurons in human colon and in Hirschsprung's disease patients. (12395377)
2002
29
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. (12169983)
2002
30
Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease. (12130725)
2002
31
CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. (11487533)
2001
32
Changed colonic profile of P-selectin, platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), ICAM-2, and ICAM-3 in inflammatory bowel disease. (10931137)
2000
33
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. (9923929)
1999
34
Low-dose cyclosporin for multiple colonic ulcers associated with mixed connective tissue disease. (10524557)
1999
35
A recurrent outbreak of nosocomial legionnaires' disease detected by urinary antigen testing: evidence for long-term colonization of a hospital plumbing system. (9872526)
1998
36
Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease. (9149061)
1997
37
Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. (8613031)
1996
38
Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. (8674385)
1996
39
Altered leukotriene B4 metabolism in colonic mucosa with inflammatory bowel disease. (7701249)
1995
40
Electrogenic colonic ion transport in Hirschsprung's disease: reduced secretion to the neural secretagogues acetylcholine and iloprost. (7694888)
1993
41
Colonic perforation: a rare complication in a patient with Ehlers-Danlos syndrome and von Willebrand's disease. (1360836)
1992
42
Colonic mucosal interleukin-6 in inflammatory bowel disease. (1804734)
1991
43
Gastric linitis plastica with metastases to the colon: a mimic of Crohn's disease. (2551955)
1989
44
Cryptococcosis of the colon resembling Crohn's disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job's) syndrome. (3338649)
1988
45
Colon interposition for benign esophageal disease. (3660233)
1987
46
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6794824)
1981
47
Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease. (101423)
1978
48
Editorial: Colonoscopy and colonic disease. (1263916)
1976
49
Four cases illustrating difficult diagnosis and complications in colonic disease. (13350305)
1956
50
Recent advances in the surgical treatment of colon and rectal disease. (18152700)
1949

Genetic Variations for Colonic Disease

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Expression for genes affiliated with Colonic Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for genes affiliated with Colonic Disease

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12EMD Millipore, 29KEGG
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Pathways related to Colonic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.5PTGS2, EGFR
2
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9.4NOS2, NOD2, PTGS2
3
Cell adhesion ECM remodeling
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9.3VTN, EGFR, PLAU
49.3NOS2, PTGS2, PLAU

Compounds for genes affiliated with Colonic Disease

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Colonic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1glutamate4410.9
2cycloheximide4410.4ADAMTSL1
3estrogen4410.3ADAMTSL1
4tamoxifen44 49 28 1112.8VTN, EGFR, CTSD
5heparin44 28 11 2412.7CTSD, VTN, ADAMTSL1
6serine449.7ADAMTSL1, VTN, NOD2
7ecotin449.7F5, PLAU
8ketorolac44 1110.7NOS2, PTGS2
9guanidine44 11 2411.7VTN, NOS2, PLAU
10fucoidan449.6ADAMTSL1, VTN, PLAU
11triptolide449.6PLAU, NOS2, PTGS2
12sodium dodecylsulfate449.6F5, VTN, ADAMTSL1
13parthenolide44 210.5PLAU, NOS2, PTGS2
14dermatan sulfate449.5VTN, PLAU, F5
15desmopressin44 59 28 1112.5F5, PLAU, PTGS2
16hirudin449.4F5, PLAU, ADAMTSL1
17dextran sulfate449.3ADAMTSL1, VTN, PLAU, F5
18kininogen449.3F5, PLAU, VTN, ADAMTSL1
19hyaluronic acid44 2410.3ADAMTSL1, VTN, PLAU, CTSD
20trastuzumab44 49 1111.3PLAU, EGFR, CTSD
21pge2449.3EGFR, PLAU, PTGS2, VTN
22progestin449.3CTSD, EGFR, F5, PLAU
23cyclopentenone449.2PTGS2, NOS2, HSPA4
24silymarin449.2EGFR, PLAU, NOS2, PTGS2
25chloroquine44 2 49 28 1113.1VTN, PLAU, CTSD, HSPA4
26aspartate448.9ADAMTSL1, VTN, CTSD, HSPA4
27epinephrine44 11 2410.9ADAMTSL1, PLAU, F5
2815-deoxy-delta-12,14-prostaglandin j2448.9HSPA4, PLAU, NOS2, PTGS2
29latex448.9HSPA4, CTSD, VTN, ADAMTSL1
30oxygen44 249.8HSPA4, CTSD, NOS2, ADAMTSL1
31cisplatin44 49 59 1111.7CTSD, EGFR, PLAU, PTGS2, VTN
32gf 109203x44 599.7HSPA4, EGFR, PLAU, PTGS2
33glutamine448.6VTN, PLAU, F5, CTSD, HSPA4
34alanine448.5HSPA4, CTSD, F5, PLAU, VTN
35prostacyclin448.5F5, PLAU, NOS2, PTGS2, VTN, ADAMTSL1
36lactate448.5HSPA4, CTSD, F5, PLAU, VTN
37fibrinogen448.4ADAMTSL1, VTN, PLAU, F5, HSPA4
38doxorubicin44 49 1110.4HSPA4, CTSD, EGFR, PLAU, NOS2
39pd 98,059448.4HSPA4, EGFR, PLAU, PTGS2, VTN
40n acetylcysteine448.3HSPA4, EGFR, PLAU, NOS2, PTGS2
41sb 20358044 599.3HSPA4, EGFR, PLAU, NOS2, PTGS2
42nitric oxide44 11 2410.1HSPA4, CTSD, F5, NOS2, NOD2, PTGS2
43herbimycin a44 599.1HSPA4, EGFR, PLAU, NOS2, PTGS2, VTN
44curcumin448.1HSPA4, EGFR, PLAU, NOS2, PTGS2, VTN
45ly294002448.1HSPA4, EGFR, PLAU, NOS2, PTGS2, VTN
46genistein44 28 59 2 11 2413.1HSPA4, CTSD, EGFR, PLAU, NOS2, PTGS2
47aspirin44 49 28 2411.1HSPA4, F5, PLAU, PTGS2, VTN, ADAMTSL1
48progesterone44 59 28 11 2412.0HSPA4, CTSD, EGFR, F5, PLAU
49retinoic acid44 248.6HSPA4, CTSD, EGFR, F5, PLAU, VTN
50vegf446.9ADAMTSL1, HSPA4, CTSD, EGFR, F5, PLAU

GO Terms for genes affiliated with Colonic Disease

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Sources:
16Gene Ontology
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Cellular components related to Colonic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6VTN, PLAU, F5, EGFR, CTSD

Biological processes related to Colonic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein catabolic processGO:0421779.6NOS2, EGFR
2innate immune response in mucosaGO:0022279.5NOD2, NOS2

Products for genes affiliated with Colonic Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colonic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet