MCID: CLN019
MIFTS: 53

Colonic Disease malady

Gastrointestinal diseases category
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Summaries for Colonic Disease

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MedlinePlus:33 Your colon, also known as the large intestine, is part of your digestive system. it's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. many disorders affect the colon's ability to work properly. some of these include colorectal cancer colonic polyps - extra tissue growing in the colon that can become cancerous ulcerative colitis - ulcers of the colon and rectum diverticulitis - inflammation or infection of pouches in the colon irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms treatment for colonic diseases varies greatly depending on the disease and its severity. treatment may involve diet, medicines and in some cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Colonic Disease, also known as colonic diseases, is related to functional colonic disease and ulcerative colitis. An important gene associated with Colonic Disease is CTSD (cathepsin D), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Immune response MIF mediated glucocorticoid regulation. The drugs scopolamine and scopolamine hydrobromide and the compounds ketorolac and piroxicam have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and small intestine, and related mouse phenotypes are digestive/alimentary and adipose tissue.

CDC:3 Of cancers affecting both men and women, colorectal cancer (cancer of the colon and rectum) is the second leading cancer killer in the United States, but it doesn't have to be. Screening can find precancerous polyps—abnormal growths in the colon or rectum—so they can be removed before turning into cancer. Screening also helps find colorectal cancer at an early stage, when treatment often leads to a cure.

Wikipedia:65 The large intestine is the last part of the digestive system in vertebrate animals. Its function is to... more...

Aliases & Classifications for Colonic Disease

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Colonic Disease, Aliases & Descriptions:

Name: Colonic Disease 8
Colonic Diseases 44 33 62
 
Diverticular Disease of Colon 8 62
Colon Disorder 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:5353
SNOMED-CT57 128524007
MeSH34 D003108

Related Diseases for Colonic Disease

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Diseases related to Colonic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1functional colonic disease30.7MLNR, HTR4
2ulcerative colitis30.0NOD2, NOS2, HSPA4
3colitis30.0PTGS2, NOS2, NOD2
4ischemia29.7HSPA4, VTN, NOS2, CTSD
5inflammatory bowel disease29.4HSPA4, PTGS2, NOS2, NOD2
6collagenous colitis10.5NOS2
7breast cancer, invasive ductal10.3NOS2, CTSD
8gastroparesis10.3HTR4, MLNR
9focal segmental glomerulosclerosis10.3VTN, NOS2
10li-fraumeni syndrome10.2CTSD, ADAMTSL1
11proliferative vitreoretinopathy10.2ADAMTSL1, VTN
12peptic ulcer disease10.2PTGS2, CTSD
13cerebral malaria10.2ADAMTSL1, NOS2
14gastrointestinal system disease10.2PTGS2, NOS2
15proliferative diabetic retinopathy10.2ADAMTSL1, VTN
16plasmodium falciparum malaria10.2NOS2, ADAMTSL1
17malaria10.2HSPA4, ADAMTSL1
18liver cirrhosis10.1CTSD, VTN, HSPA4
19breast ductal carcinoma10.1EGFR, CTSD
20adenosquamous carcinoma10.1EGFR, CTSD
21sarcoidosis10.1NOD2, VTN, HSPA4
22glomerulonephritis10.1NOS2, VTN, ADAMTSL1
23interstitial lung disease10.1VTN, EGFR
24hyperglycemia10.1ADAMTSL1, VTN, NOS2
25laryngeal benign neoplasm10.1CTSD, EGFR
26tuberculosis10.1CTSD, NOD2, HSPA4
27mucoepidermoid carcinoma10.1NOS2, EGFR
28factor v leiden thrombophilia10.1HSPA4, ADAMTSL1, CTSD
29coronary artery anomaly10.0HSPA4, ADAMTSL1, VTN
30diabetic retinopathy10.0NOS2, VTN
31laryngeal squamous cell carcinoma10.0EGFR, CTSD
32vascular disease10.0HSPA4, PTGS2, NOS2
33primary hyperoxaluria10.0NOS2, VTN, ADAMTSL1
34prion disease10.0HSPA4, PTGS2
35sepsis10.0ADAMTSL1, VTN, NOS2, NOD2
36congenital heart disease10.0HSPA4, ADAMTSL1, NOS2
37sclerosing cholangitis10.0
38cholangitis10.0
39primary sclerosing cholangitis10.0
40asthma9.9NOD2, NOS2, VTN, HSPA4
41osteosarcoma9.9HSPA4, ADAMTSL1, VTN
42bladder carcinoma in situ9.9PTGS2, EGFR
43leukemia9.9CTSD, ADAMTSL1, HSPA4
44transitional cell carcinoma9.9PTGS2, EGFR, CTSD
45breast cancer9.9CTSD, EGFR, PTGS2
46diabetes mellitus9.9VTN, ADAMTSL1, HSPA4
47cervical cancer9.9CTSD, EGFR, PTGS2
48bladder carcinoma9.8CTSD, EGFR, PTGS2
49stomach cancer9.8PTGS2, EGFR, CTSD
50alzheimer's disease9.8CTSD, NOS2, ADAMTSL1, PTGS2

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to colonic disease

Symptoms for Colonic Disease

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Drugs & Therapeutics for Colonic Disease

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Drug clinical trials:

Search ClinicalTrials for Colonic Disease

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Colonic Disease

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Anatomical Context for Colonic Disease

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MalaCards organs/tissues related to Colonic Disease:

32
Colon, Kidney, Small intestine, Liver, Skin

Animal Models for Colonic Disease or affiliated genes

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MGI Mouse Phenotypes related to Colonic Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8PTGS2, NOS2, NOD2, EGFR, CTSD
2MP:00053758.7PTGS2, HTR4, NOS2, EGFR
3MP:00053978.4PTGS2, VTN, NOS2, NOD2, EGFR, CTSD
4MP:00053798.1HSPA4, PTGS2, NOS2, EGFR, CTSD
5MP:00053788.0CTSD, EGFR, NOD2, NOS2, HTR4, PTGS2
6MP:00053767.8CTSD, EGFR, NOD2, NOS2, VTN, HTR4
7MP:00053847.7HSPA4, PTGS2, NOS2, NOD2, EGFR, CTSD
8MP:00107687.3HSPA4, PTGS2, HTR4, NOS2, NOD2, EGFR
9MP:00036317.2HSPA4, PTGS2, HTR4, NOS2, EGFR, CTSD

Publications for Colonic Disease

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Articles related to Colonic Disease:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Is proliferative colonic disease presentation changing? (23236236)
2012
2
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. (22427959)
2012
3
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. (21825842)
2011
4
Colonic perforation during barium enema in a patient without known colonic disease: a case report. (19918538)
2009
5
Acute colonic disease: how to image in emergency. (17174054)
2007
6
Death from colonic disease in epidermolysis bullosa dystrophica. (16480504)
2006
7
Colonic perforation at CT colonography in a patient without known colonic disease. (16357389)
2006
8
Cerebrospinal fluid polyamine levels in patients with colonic disease. (12567356)
2003
9
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. (16378294)
2002
10
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. (11913411)
2002
11
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. (11595480)
2001
12
Investigation of colonic disease. (11103279)
2000
13
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. (9923929)
1999
14
Psoas abscesses complicating colonic disease: imaging and therapy. (10645182)
1999
15
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. (9600375)
1998
16
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. (9443117)
1998
17
Psoas abscesses complicating colonic disease: imaging and therapy. (10209409)
1998
18
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. (9150951)
1997
19
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. (9412955)
1997
20
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. (9106695)
1997
21
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. (8942726)
1996
22
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. (8587011)
1995
23
Glycosylation patterns of mucins in colonic disease. (8654850)
1995
24
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. (8099272)
1993
25
The antegrade colonogram: extending the small bowel follow through for children suspected of having colonic disease. (1491931)
1992
26
Schistosomal colonic disease. (2110925)
1990
27
A morphometric study of the canine colon: comparison of control dogs and cases of colonic disease. (2249180)
1990
28
A new model for inflammatory colonic disease induced by capsaicin in rats. (2711937)
1989
29
Size of flour particles and its relation to glycaemia, insulinaemia, and colonic disease. (2503150)
1989
30
Human skin fibroblast in vitro tetraploidy. Flow cytometric DNA assay used to confirm metaphase assay in patients with various colonic diseases. (2752376)
1989
31
Anorectal and colonic disease and the immunocompromised host. (3063471)
1988
32
Should colonoscopy be the first investigation for colonic disease? (3126910)
1988
33
Colonoscopy or barium enema as initial investigation of colonic disease. (2887839)
1987
34
Combined use of double- and single-contrast barium enema in the evaluation of suspected colonic disease. (6468861)
1984
35
Colonic disease in patients receiving hemodialysis. (7059250)
1982
36
Mucosal microhernias in the nonhuman primate colon: their role in the pathogenesis of colonic disease. (6815871)
1982
37
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6796184)
1981
38
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6794824)
1981
39
Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease. (101423)
1978
40
High-fiber diets and colonic disease. (584140)
1977
41
Isolated small bowel obstruction as the presenting feature of colonic disease. (880024)
1977
42
Editorial: Colonoscopy and colonic disease. (1263916)
1976
43
Letter: Peripheral lymphocyte counts in colonic disease. (4136971)
1974
44
Fiberoptic colonoscopy in the management of colonic disease. (4543591)
1974
45
Use of fibreoptic colonoscopy for investigating rectal and colonic disease. (4539316)
1972
46
Diet and colonic disease. (4554581)
1972
47
The radiology corner. Ischemic colonic disease associated with carcinoma of the colon. (5098216)
1971
48
Fibinolysis in colonic disease. (5452047)
1970
49
PLAIN ABDOMINAL FILMS IN COLONIC DISEASE. (14214791)
1964
50
THE CONSIDERATION OF RECTAL AND COLONIC DISEASE IN LIFE INSURANCE EXAMINATIONS. (18737136)
1916

Variations for Colonic Disease

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Expression for genes affiliated with Colonic Disease

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Expression patterns in normal tissues for genes affiliated with Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for genes affiliated with Colonic Disease

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Pathways related to Colonic Disease according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTGS2, NOS2
29.7NOS2, PTGS2
39.6EGFR, NOS2
49.5NOS2, NOD2, CTSD
5
Show member pathways
9.3NOD2, NOS2, PTGS2
6
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.3EGFR, VTN, PTGS2
7
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.3EGFR, VTN, PTGS2
8
Show member pathways
9.3HSPA4, NOS2
99.2EGFR, NOS2, PTGS2
109.0EGFR, NOS2, HTR4
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9EGFR, NOD2, NOS2, PTGS2

Compounds for genes affiliated with Colonic Disease

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Compounds related to Colonic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ketorolac44 1111.1PTGS2, NOS2
2piroxicam44 1111.0EGFR
3mafp4410.0NOS2, PTGS2
4grgds449.9VTN, ADAMTSL1
5silymarin449.7PTGS2, NOS2, EGFR
6rebamipide449.6NOS2, HSPA4
7tirofiban44 1110.6VTN, ADAMTSL1
8celecoxib44 61 28 50 24 1114.6PTGS2, NOS2, EGFR
9hyaluronic acid44 2410.5ADAMTSL1, VTN, CTSD
10egcg449.5EGFR, NOS2, PTGS2
11mannose449.5CTSD, NOD2, ADAMTSL1
12chloroquine44 2 50 28 1113.4HSPA4, VTN, CTSD
13c2ceramide449.4HSPA4, NOS2, CTSD
14nocodazole44 1110.4HSPA4, VTN, CTSD
15cyclopentenone449.3HSPA4, PTGS2, NOS2
16cisplatin44 50 61 1112.3CTSD, EGFR, VTN, PTGS2
17prostacyclin449.3PTGS2, ADAMTSL1, VTN, NOS2
1815-deoxy-delta-12,14-prostaglandin j2449.3NOS2, PTGS2, HSPA4
19resveratrol44 61 24 1112.2HSPA4, PTGS2, NOS2
20gemcitabine44 50 1111.1HSPA4, PTGS2, EGFR
21gf 109203x44 6110.1HSPA4, PTGS2, EGFR
22pge2449.0PTGS2, VTN, NOS2, EGFR, CTSD
23mg 13244 6110.0HSPA4, NOS2, EGFR
24cisapride44 28 1111.0HTR4, MLNR
25tamoxifen44 50 28 1112.0CTSD, EGFR, VTN, HSPA4
26latex448.9HSPA4, ADAMTSL1, VTN, CTSD
27doxorubicin44 50 1110.9CTSD, EGFR, NOS2, HSPA4
28pd 98,059448.8EGFR, VTN, PTGS2, HSPA4
29n acetylcysteine448.8HSPA4, PTGS2, NOS2, EGFR
30sb 20358044 619.8HSPA4, PTGS2, NOS2, EGFR
31aspirin44 50 28 2411.8VTN, ADAMTSL1, PTGS2, HSPA4
32prostaglandin448.8ADAMTSL1, PTGS2, HSPA4
33aspartate448.8HSPA4, ADAMTSL1, VTN, CTSD
34heparin44 28 24 1111.8HSPA4, ADAMTSL1, VTN, CTSD
35estrogen448.8PTGS2, ADAMTSL1, NOS2, EGFR, CTSD
36nitric oxide44 24 1110.6HSPA4, PTGS2, NOS2, NOD2, CTSD
37h2o2448.6HSPA4, ADAMTSL1, NOS2, CTSD
38genistein44 28 61 2 24 1113.5HSPA4, PTGS2, NOS2, EGFR, CTSD
39herbimycin a44 619.5HSPA4, PTGS2, VTN, NOS2, EGFR
40curcumin448.5EGFR, NOS2, VTN, PTGS2, HSPA4
41ly294002448.5EGFR, NOS2, VTN, PTGS2, HSPA4
42dexamethasone44 50 28 1111.4NOS2, VTN, ADAMTSL1, PTGS2, HSPA4
43glutamate448.4HSPA4, HTR4, VTN, NOS2, CTSD
44cholesterol44 28 24 1111.4HSPA4, ADAMTSL1, VTN, CTSD
45retinoic acid44 249.4HSPA4, ADAMTSL1, VTN, EGFR, CTSD
46calcium44 50 24 1111.3MLNR, ADAMTSL1, VTN, NOS2, NOD2, CTSD
47oxygen44 249.1HSPA4, PTGS2, ADAMTSL1, NOS2, NOD2, CTSD
48serine448.1CTSD, EGFR, NOD2, VTN, ADAMTSL1, HSPA4
49cycloheximide447.7CTSD, HSPA4, PTGS2, ADAMTSL1, VTN, NOS2
50vegf447.7HSPA4, PTGS2, ADAMTSL1, VTN, NOS2, EGFR

GO Terms for genes affiliated with Colonic Disease

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Biological processes related to Colonic Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:00222710.0NOD2, NOS2
2positive regulation of synaptic transmission, glutamatergicGO:0519689.8EGFR, PTGS2
3negative regulation of protein catabolic processGO:0421779.8EGFR, NOS2
4positive regulation of vasoconstrictionGO:0459079.8PTGS2, EGFR
5positive regulation of vasodilationGO:0459099.8EGFR, NOS2
6positive regulation of nitric oxide biosynthetic processGO:0454299.7PTGS2, EGFR
7regulation of inflammatory responseGO:0507279.6NOD2, PTGS2
8positive regulation of smooth muscle cell proliferationGO:0486619.6EGFR, PTGS2
9cellular response to mechanical stimulusGO:0712609.6EGFR, PTGS2
10positive regulation of epithelial cell proliferationGO:0506799.4EGFR, NOD2

Molecular functions related to Colonic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.3EGFR, NOD2, PTGS2

Products for genes affiliated with Colonic Disease

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  • Antibodies
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Sources for Colonic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet