MCID: CLN019
MIFTS: 53

Colonic Disease malady

Gastrointestinal diseases category

Summaries for Colonic Disease

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Sources:
35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your colon, also known as the large intestine, is part of your digestive system. it's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. many disorders affect the colon's ability to work properly. some of these include colorectal cancer colonic polyps - extra tissue growing in the colon that can become cancerous ulcerative colitis - ulcers of the colon and rectum diverticulitis - inflammation or infection of pouches in the colon irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms treatment for colonic diseases varies greatly depending on the disease and its severity. treatment may involve diet, medicines and in some cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Colonic Disease, also known as colonic diseases, is related to functional colonic disease and ulcerative colitis. An important gene associated with Colonic Disease is CTSD (cathepsin D), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Immune response MIF mediated glucocorticoid regulation. The drugs scopolamine and scopolamine hydrobromide and the compounds ketorolac and piroxicam have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and small intestine, and related mouse phenotypes are digestive/alimentary and adipose tissue.

CDC:4 Of cancers affecting both men and women, colorectal cancer (cancer of the colon and rectum) is the second leading cancer killer in the United States, but it doesn't have to be. Screening can find precancerous polypsā€”abnormal growths in the colon or rectumā€”so they can be removed before turning into cancer. Screening also helps find colorectal cancer at an early stage, when treatment often leads to a cure.

Wikipedia:66 The large intestine is the last part of the digestive system in vertebrate animals. Its function is to... more...

Aliases & Classifications for Colonic Disease

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Sources:
9Disease Ontology, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

colonic disease 9
colonic diseases 46 35 63
diverticular disease of colon 9
colon disorder 9


External Ids:

Disease Ontology9 DOID:5353
SNOMED-CT59 128524007
MeSH36 D003108

Related Diseases for Colonic Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Colonic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1functional colonic disease30.3MLNR, HTR4
2ulcerative colitis29.9NOD2, NOS2, HSPA4
3ischemia29.7HSPA4, VTN, NOS2, CTSD
4inflammatory bowel disease29.6HSPA4, PTGS2, NOS2, NOD2
5colon cancer29.5PTGS2, ADAMTSL1, NOS2, EGFR, CTSD
6collagenous colitis10.1NOS2
7breast cancer, invasive ductal10.1NOS2, CTSD
8gastroparesis10.1HTR4, MLNR
9focal segmental glomerulosclerosis10.1VTN, NOS2
10li-fraumeni syndrome10.1CTSD, ADAMTSL1
11proliferative vitreoretinopathy10.1ADAMTSL1, VTN
12cerebral malaria10.0ADAMTSL1, NOS2
13peptic ulcer disease10.0PTGS2, CTSD
14gastrointestinal system disease10.0PTGS2, NOS2
15proliferative diabetic retinopathy10.0ADAMTSL1, VTN
16plasmodium falciparum malaria10.0NOS2, ADAMTSL1
17malaria10.0HSPA4, ADAMTSL1
18liver cirrhosis10.0CTSD, VTN, HSPA4
19adenosquamous carcinoma10.0EGFR, CTSD
20sarcoidosis10.0NOD2, VTN, HSPA4
21glomerulonephritis10.0NOS2, VTN, ADAMTSL1
22interstitial lung disease10.0VTN, EGFR
23hyperglycemia10.0ADAMTSL1, VTN, NOS2
24laryngeal benign neoplasm10.0CTSD, EGFR
25tuberculosis10.0CTSD, NOD2, HSPA4
26mucoepidermoid carcinoma10.0NOS2, EGFR
27factor v leiden thrombophilia10.0HSPA4, ADAMTSL1, CTSD
28coronary artery disease10.0HSPA4, ADAMTSL1, VTN
29diabetic retinopathy10.0NOS2, VTN
30laryngeal squamous cell carcinoma10.0EGFR, CTSD
31primary hyperoxaluria10.0NOS2, VTN, ADAMTSL1
32vascular disease10.0HSPA4, PTGS2, NOS2
33prion disease10.0HSPA4, PTGS2
34sepsis10.0ADAMTSL1, VTN, NOS2, NOD2
35congenital heart disease10.0HSPA4, ADAMTSL1, NOS2
36osteosarcoma10.0HSPA4, ADAMTSL1, VTN
37asthma10.0NOD2, NOS2, VTN, HSPA4
38bladder carcinoma in situ10.0PTGS2, EGFR
39leukemia10.0CTSD, ADAMTSL1, HSPA4
40transitional cell carcinoma10.0PTGS2, EGFR, CTSD
41breast cancer10.0CTSD, EGFR, PTGS2
42diabetes mellitus10.0VTN, ADAMTSL1, HSPA4
43cervical cancer10.0CTSD, EGFR, PTGS2
44bladder carcinoma10.0CTSD, EGFR, PTGS2
45stomach cancer10.0PTGS2, EGFR, CTSD
46alzheimer's disease10.0CTSD, NOS2, ADAMTSL1, PTGS2
47oral cancer10.0EGFR, PTGS2, HSPA4
48colorectal cancer10.0PTGS2, EGFR, CTSD
49non-small cell lung carcinoma9.9HSPA4, PTGS2, EGFR
50esophageal cancer9.9PTGS2, EGFR

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to colonic disease

Symptoms for Colonic Disease

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Drugs & Therapeutics for Colonic Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colonic Disease

Drug clinical trials:

Search ClinicalTrials for Colonic Disease

Search NIH Clinical Center for Colonic Disease

Search CenterWatch for Colonic Disease

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Colonic Disease

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Anatomical Context for Colonic Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Colonic Disease:

34
Colon, Kidney, Small intestine, Liver, Skin

Animal Models for Colonic Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Colonic Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8PTGS2, NOS2, NOD2, EGFR, CTSD
2MP:00053758.7PTGS2, HTR4, NOS2, EGFR
3MP:00053978.4PTGS2, VTN, NOS2, NOD2, EGFR, CTSD
4MP:00053798.1HSPA4, PTGS2, NOS2, EGFR, CTSD
5MP:00053788.0CTSD, EGFR, NOD2, NOS2, HTR4, PTGS2
6MP:00053767.8CTSD, EGFR, NOD2, NOS2, VTN, HTR4
7MP:00053847.7HSPA4, PTGS2, NOS2, NOD2, EGFR, CTSD
8MP:00107687.3HSPA4, PTGS2, HTR4, NOS2, NOD2, EGFR
9MP:00036317.2HSPA4, PTGS2, HTR4, NOS2, EGFR, CTSD

Publications for Colonic Disease

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Sources:
53PubMed
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Articles related to Colonic Disease:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Is proliferative colonic disease presentation changing? (23236236)
2012
2
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. (22427959)
2012
3
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. (21825842)
2011
4
Colonic perforation during barium enema in a patient without known colonic disease: a case report. (19918538)
2009
5
Acute colonic disease: how to image in emergency. (17174054)
2007
6
Death from colonic disease in epidermolysis bullosa dystrophica. (16480504)
2006
7
Colonic perforation at CT colonography in a patient without known colonic disease. (16357389)
2006
8
Cerebrospinal fluid polyamine levels in patients with colonic disease. (12567356)
2003
9
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. (16378294)
2002
10
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. (11913411)
2002
11
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. (11595480)
2001
12
Investigation of colonic disease. (11103279)
2000
13
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. (9923929)
1999
14
Psoas abscesses complicating colonic disease: imaging and therapy. (10645182)
1999
15
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. (9600375)
1998
16
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. (9443117)
1998
17
Psoas abscesses complicating colonic disease: imaging and therapy. (10209409)
1998
18
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. (9150951)
1997
19
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. (9412955)
1997
20
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. (9106695)
1997
21
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. (8942726)
1996
22
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. (8587011)
1995
23
Glycosylation patterns of mucins in colonic disease. (8654850)
1995
24
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. (8099272)
1993
25
The antegrade colonogram: extending the small bowel follow through for children suspected of having colonic disease. (1491931)
1992
26
Schistosomal colonic disease. (2110925)
1990
27
A morphometric study of the canine colon: comparison of control dogs and cases of colonic disease. (2249180)
1990
28
A new model for inflammatory colonic disease induced by capsaicin in rats. (2711937)
1989
29
Size of flour particles and its relation to glycaemia, insulinaemia, and colonic disease. (2503150)
1989
30
Human skin fibroblast in vitro tetraploidy. Flow cytometric DNA assay used to confirm metaphase assay in patients with various colonic diseases. (2752376)
1989
31
Anorectal and colonic disease and the immunocompromised host. (3063471)
1988
32
Should colonoscopy be the first investigation for colonic disease? (3126910)
1988
33
99mTc-sucralfate scintigraphy and colonic disease. (3117238)
1987
34
Colonoscopy or barium enema as initial investigation of colonic disease. (2887839)
1987
35
Combined use of double- and single-contrast barium enema in the evaluation of suspected colonic disease. (6468861)
1984
36
Colonic disease in patients receiving hemodialysis. (7059250)
1982
37
Mucosal microhernias in the nonhuman primate colon: their role in the pathogenesis of colonic disease. (6815871)
1982
38
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6796184)
1981
39
Flexible sigmoidoscopy in outpatients with suspected colonic disease. (6794824)
1981
40
Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease. (101423)
1978
41
High-fiber diets and colonic disease. (584140)
1977
42
Isolated small bowel obstruction as the presenting feature of colonic disease. (880024)
1977
43
Editorial: Colonoscopy and colonic disease. (1263916)
1976
44
Letter: Peripheral lymphocyte counts in colonic disease. (4136971)
1974
45
Fiberoptic colonoscopy in the management of colonic disease. (4543591)
1974
46
Use of fibreoptic colonoscopy for investigating rectal and colonic disease. (4539316)
1972
47
Diet and colonic disease. (4554581)
1972
48
Fibinolysis in colonic disease. (5452047)
1970
49
PLAIN ABDOMINAL FILMS IN COLONIC DISEASE. (14214791)
1964
50
THE CONSIDERATION OF RECTAL AND COLONIC DISEASE IN LIFE INSURANCE EXAMINATIONS. (18737136)
1916

Variations for Colonic Disease

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Expression for genes affiliated with Colonic Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for genes affiliated with Colonic Disease

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 54QIAGEN, 56Reactome, 55R&D Systems
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Pathways related to Colonic Disease according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTGS2, NOS2
29.7NOS2, PTGS2
39.6EGFR, NOS2
49.5NOS2, NOD2, CTSD
5
Show member pathways
9.3NOD2, NOS2, PTGS2
6
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.3EGFR, VTN, PTGS2
7
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.3EGFR, VTN, PTGS2
8
Show member pathways
9.3HSPA4, NOS2
99.2EGFR, NOS2, PTGS2
109.0EGFR, NOS2, HTR4
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.9EGFR, NOD2, NOS2, PTGS2

Compounds for genes affiliated with Colonic Disease

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Colonic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ketorolac46 1211.1PTGS2, NOS2
2piroxicam46 1211.0EGFR
3mafp4610.0NOS2, PTGS2
4grgds469.9VTN, ADAMTSL1
5silymarin469.7PTGS2, NOS2, EGFR
6rebamipide469.6NOS2, HSPA4
7tirofiban46 1210.6VTN, ADAMTSL1
8celecoxib46 62 30 52 25 1214.6NOS2, PTGS2, EGFR
9hyaluronic acid46 2510.5ADAMTSL1, VTN, CTSD
10egcg469.5PTGS2, NOS2, EGFR
11mannose469.5ADAMTSL1, NOD2, CTSD
12chloroquine46 3 52 30 1213.4VTN, HSPA4, CTSD
13c2ceramide469.4HSPA4, NOS2, CTSD
14nocodazole46 1210.4CTSD, VTN, HSPA4
15cyclopentenone469.3HSPA4, PTGS2, NOS2
16cisplatin46 52 62 1212.3VTN, CTSD, EGFR, PTGS2
17prostacyclin469.3VTN, PTGS2, NOS2, ADAMTSL1
1815-deoxy-delta-12,14-prostaglandin j2469.3HSPA4, PTGS2, NOS2
19resveratrol46 62 25 1212.2HSPA4, NOS2, PTGS2
20gemcitabine46 52 1211.1HSPA4, PTGS2, EGFR
21gf 109203x46 6210.1HSPA4, EGFR, PTGS2
22pge2469.0CTSD, VTN, EGFR, NOS2, PTGS2
23mg 13246 6210.0EGFR, NOS2, HSPA4
24cisapride46 30 1211.0MLNR, HTR4
25tamoxifen46 52 30 1212.0CTSD, EGFR, HSPA4, VTN
26latex468.9VTN, CTSD, HSPA4, ADAMTSL1
27doxorubicin46 52 1210.9CTSD, HSPA4, EGFR, NOS2
28pd 98,059468.8VTN, EGFR, HSPA4, PTGS2
29n acetylcysteine468.8PTGS2, EGFR, HSPA4, NOS2
30sb 20358046 629.8EGFR, NOS2, HSPA4, PTGS2
31aspirin46 52 30 2511.8VTN, PTGS2, ADAMTSL1, HSPA4
32prostaglandin468.8ADAMTSL1, PTGS2, HSPA4
33aspartate468.8VTN, CTSD, ADAMTSL1, HSPA4
34heparin46 30 25 1211.8ADAMTSL1, HSPA4, CTSD, VTN
35estrogen468.8PTGS2, ADAMTSL1, NOS2, EGFR, CTSD
36nitric oxide46 25 1210.6NOD2, CTSD, PTGS2, NOS2, HSPA4
37h2o2468.6NOS2, ADAMTSL1, HSPA4, CTSD
38genistein46 30 62 3 25 1213.5CTSD, HSPA4, PTGS2, NOS2, EGFR
39herbimycin a46 629.5EGFR, NOS2, VTN, PTGS2, HSPA4
40curcumin468.5HSPA4, PTGS2, VTN, NOS2, EGFR
41ly294002468.5NOS2, EGFR, VTN, PTGS2, HSPA4
42dexamethasone46 52 30 1211.4NOS2, VTN, ADAMTSL1, PTGS2, HSPA4
43glutamate468.4HSPA4, NOS2, HTR4, CTSD, VTN
44cholesterol46 30 25 1211.4HSPA4, CTSD, VTN, ADAMTSL1
45retinoic acid46 259.4VTN, ADAMTSL1, EGFR, HSPA4, CTSD
46calcium46 52 25 1211.3MLNR, ADAMTSL1, VTN, CTSD, NOD2, NOS2
47oxygen46 259.1CTSD, NOS2, ADAMTSL1, PTGS2, HSPA4, NOD2
48serine468.1EGFR, ADAMTSL1, VTN, HSPA4, CTSD, NOD2
49cycloheximide467.7PTGS2, CTSD, EGFR, NOS2, HSPA4, ADAMTSL1
50vegf467.7HSPA4, PTGS2, ADAMTSL1, VTN, NOS2, EGFR

GO Terms for genes affiliated with Colonic Disease

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Sources:
17Gene Ontology
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Biological processes related to Colonic Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:00222710.0NOD2, NOS2
2positive regulation of synaptic transmission, glutamatergicGO:0519689.8EGFR, PTGS2
3negative regulation of protein catabolic processGO:0421779.8EGFR, NOS2
4positive regulation of vasoconstrictionGO:0459079.8PTGS2, EGFR
5positive regulation of vasodilationGO:0459099.8EGFR, NOS2
6positive regulation of nitric oxide biosynthetic processGO:0454299.7PTGS2, EGFR
7regulation of inflammatory responseGO:0507279.6NOD2, PTGS2
8positive regulation of smooth muscle cell proliferationGO:0486619.6EGFR, PTGS2
9cellular response to mechanical stimulusGO:0712609.6EGFR, PTGS2
10positive regulation of epithelial cell proliferationGO:0506799.4EGFR, NOD2

Molecular functions related to Colonic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.3EGFR, NOD2, PTGS2

Products for genes affiliated with Colonic Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colonic Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet