MCID: CLN019
MIFTS: 51

Colonic Disease malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Disease

Aliases & Descriptions for Colonic Disease:

Name: Colonic Disease 12 14
Colonic Diseases 52 41 42 69
Colon Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5353
MeSH 42 D003108
SNOMED-CT 64 128524007
UMLS 69 C0009373

Summaries for Colonic Disease

MedlinePlus : 41 your colon, also known as the large intestine, is part of your digestive system. it's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. many disorders affect the colon's ability to work properly. some of these include colorectal cancer colonic polyps - extra tissue growing in the colon that can become cancerous ulcerative colitis - ulcers of the colon and rectum diverticulitis - inflammation or infection of pouches in the colon irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms treatment for colonic diseases varies greatly depending on the disease and its severity. treatment may involve diet, medicines and in some cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Colonic Disease, also known as colonic diseases, is related to functional colonic disease and megacolon, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colonic Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are GDNF-Family Ligands and Receptor Interactions and Neural Crest Differentiation. The drugs Heparin and Rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and behavior/neurological

Related Diseases for Colonic Disease

Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 functional colonic disease 11.8
2 megacolon 10.6
3 diverticulitis of colon 10.6
4 bladder clear cell adenocarcinoma 10.3 CTSD ESR1
5 epiphyseal dysplasia, multiple, 3 10.2 EDN3 EDNRB
6 deafness, mitochondrial, modifier of 10.2 EDNRB SOX10
7 waardenburg syndrome, type 4a 10.2 EDNRB RET
8 meigel disease 10.2 GDNF RET
9 wdha syndrome 10.2 EDN3 EDNRB SOX10
10 apocrine adenoma 10.2 EDNRB RET SOX10
11 cervical adenofibroma 10.1 EDN3 EDNRB SOX10
12 sweat gland cancer 10.1 EDNRB GDNF RET
13 waardenburg syndrome, type 3 10.1 EDN3 SOX10
14 hypoparathyroidism-intellectual disability-dysmorphism syndrome 10.1 ACHE GDNF RET
15 uterine ligament clear cell adenocarcinoma 10.1 EDNRB NOD2 RET
16 ceroid lipofuscinosis, neuronal, 5 10.1 EDN3 EDNRB RET SOX10
17 central hypoventilation syndrome, congenital 10.1 GDNF GFRA1 RET
18 myopathy of extraocular muscle 10.0 EDN3 EDNRB RET SOX10
19 hemopericardium 10.0 ASCL1 EDNRB PHOX2B
20 nonsyndromic congenital nail disorder 5 10.0 ACHE GFRA1
21 hirschsprung disease 1 10.0 EDNRB GDNF GFRA1 RET
22 familial cold autoinflammatory syndrome 4 10.0 ACHE RET
23 shprintzen-goldberg syndrome 9.8 ASCL1 EDN3 EDNRB GDNF RET
24 neutropenia, severe congenital, 5, autosomal recessive 9.8 ASCL1 EDNRB GDNF GFRA1 RET
25 chronic infections, due to mbl deficiency 9.7 ASCL1 EDN3 EDNRB GDNF PHOX2B RET
26 hemochromatosis, type 2a 9.7 GDNF NRTN UCHL1
27 crohn's disease 9.6
28 ulcerative colitis 9.5
29 familial adenomatous polyposis 9.5
30 colitis 9.5
31 mucositis 9.5
32 sclerosing cholangitis 9.5
33 cholangitis 9.5
34 ariboflavinosis 9.5 ACHE EDN3 EDNRB GDNF NOD2 NRTN
35 cystic fibrosis 9.3
36 epidermolysis bullosa dystrophica 9.3
37 hepatitis 9.3
38 inflammatory bowel disease 9.3
39 portal hypertension 9.3
40 epidermolysis bullosa 9.3
41 ischemia 9.3
42 merkel cell carcinoma 9.3
43 tetraploidy 9.3
44 spinal meningioma 9.2 ACHE EDN3 EDNRB GDNF NRTN PHOX2B
45 tooth agenesis, selective, 5 8.3 ACHE ASCL1 CTSD EDN3 EDNRB GDNF
46 skin pilomatrix carcinoma 8.0 ACHE ASCL1 CTSD EDN3 EDNRB ESR1

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to Colonic Disease

Symptoms & Phenotypes for Colonic Disease

UMLS symptoms related to Colonic Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Colonic Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 ZEB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.85 CTSD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.85 ZEB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 CTSD SOX10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.85 STAT3 ZEB2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.85 STAT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 RET
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.85 RET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.85 CTSD
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.85 ZEB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.85 RET
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 ZEB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 RET
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.85 SOX10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 RET
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.85 SOX10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.85 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 RET
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.85 CTSD
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 ZEB2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 SOX10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 CTSD RET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.85 SOX10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.85 STAT3 ZEB2 CTSD RET SOX10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.85 CTSD
28 Decreased Aire reporter expression GR00304-A 9.26 ASCL1 ESR1 SOX10 ZEB2

MGI Mouse Phenotypes related to Colonic Disease:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 PHOX2B RET SOX10 ACHE ASCL1 CTSD
2 cellular MP:0005384 10.34 ASCL1 CTSD EDNRB ESR1 GDNF GFRA1
3 growth/size/body region MP:0005378 10.3 ACHE ASCL1 CTSD EDNRB ESR1 GDNF
4 digestive/alimentary MP:0005381 10.29 SOX10 STAT3 UCHL1 CTSD EDN3 EDNRB
5 mortality/aging MP:0010768 10.27 ACHE ASCL1 CTSD EDN3 EDNRB ESR1
6 cardiovascular system MP:0005385 10.19 CTSD EDNRB ESR1 GDNF KIDINS220 PHOX2B
7 nervous system MP:0003631 10.16 ACHE ASCL1 CTSD EDN3 EDNRB ESR1
8 embryo MP:0005380 10.15 EDN3 EDNRB ESR1 GFRA1 PHOX2B RET
9 endocrine/exocrine gland MP:0005379 10.13 ASCL1 CTSD EDNRB ESR1 GDNF NRTN
10 immune system MP:0005387 10.09 CTSD EDNRB ESR1 GDNF GFRA1 NOD2
11 integument MP:0010771 10.06 EDN3 EDNRB ESR1 GFRA1 SOX10 STAT3
12 muscle MP:0005369 9.92 ACHE EDNRB ESR1 GDNF GFRA1 NRTN
13 renal/urinary system MP:0005367 9.7 STAT3 UCHL1 EDNRB ESR1 GDNF GFRA1
14 respiratory system MP:0005388 9.61 ASCL1 EDNRB ESR1 PHOX2B RET SOX10
15 vision/eye MP:0005391 9.28 ACHE ASCL1 CTSD EDNRB KIDINS220 NRTN

Drugs & Therapeutics for Colonic Disease

Drugs for Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1003)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
2
Rosiglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 122320-73-4 77999
3
Zinc Approved Phase 4 7440-66-6 32051 23994
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
6
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
7
Loperamide Approved Phase 4,Phase 2,Phase 3,Phase 1 53179-11-6 3955
8
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 59467-70-8 4192
9
Erythromycin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 114-07-8 12560
10
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128-13-2 31401
11
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
12
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
13
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
14
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
15
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
16
Azathioprine Approved Phase 4,Phase 2,Phase 3 446-86-6 2265
17
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
18
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
19
Pentoxifylline Approved, Investigational Phase 4,Phase 2 6493-05-6 4740
20
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
21
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 137-58-6 3676
22
Lactulose Approved Phase 4,Phase 1 4618-18-2 11333
23
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
24
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
25
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
26
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
27
Ketorolac Approved Phase 4,Phase 2 74103-06-3, 66635-83-4 3826
28
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
29
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 564-25-0 54671203
30
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
31 Tegafur Approved Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7
32
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
33
Lubiprostone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136790-76-6 656719
34
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 2078-54-8 4943
35
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
36
Hydromorphone Approved, Illicit Phase 4,Phase 2 466-99-9 5284570
37
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
38
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
39
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
40
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 437-38-7 3345
41
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
42
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
43
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
44
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2 80621-81-4 6436173
45
Nitazoxanide Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 55981-09-4 41684
46
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
47
Pancrelipase Approved Phase 4,Phase 1,Phase 2 53608-75-6
48
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
49
Bisacodyl Approved Phase 4,Phase 3 603-50-9
50
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2

Interventional clinical trials:

(show top 50) (show all 5000)
id Name Status NCT ID Phase
1 Multidisciplinary Approach Versus Conventional Approach in Colonic Preparation of Hospitalized Patients Unknown status NCT01853709 Phase 4
2 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4
3 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4
4 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4
5 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
6 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4
7 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
8 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4
9 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
10 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4
11 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4
12 Probiotic in Irritable Bowel Syndrome (IBS) Patients With Diarrhea Unknown status NCT01667627 Phase 4
13 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4
14 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4
15 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4
16 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4
17 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4
18 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4
19 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4
20 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
21 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4
22 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4
23 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4
24 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4
25 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4
26 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
27 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4
28 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4
29 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4
30 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4
31 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4
32 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
33 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4
34 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4
35 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4
36 Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases Unknown status NCT01337440 Phase 4
37 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4
38 Late Incomplete Stent Apposition Evaluation II: Comparison Between Polimer-based and No-polimer Stent System. IVUS Based Study Unknown status NCT01375855 Phase 4
39 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
40 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
41 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4
42 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4
43 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
44 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
45 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
46 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4
47 EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth Completed NCT00331994 Phase 4
48 Mesalazine and/or Lactobacillus Casei in the Diverticular Disease of the Colon Completed NCT01534754 Phase 4
49 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
50 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: colonic diseases

Genetic Tests for Colonic Disease

Anatomical Context for Colonic Disease

MalaCards organs/tissues related to Colonic Disease:

39
Colon, Kidney, Skin, Liver, Small Intestine

Publications for Colonic Disease

Articles related to Colonic Disease:

(show top 50) (show all 85)
id Title Authors Year
1
Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric Crohn's disease. ( 26653943 )
2016
2
Advances in colonic disease: some light at the end of the tunnel at the end of the light! ( 26628103 )
2016
3
Single-incision versus standard multi-incision laparoscopic colectomy in patients with malignant or benign colonic disease: a systematic review, meta-analysis and assessment of the evidence. ( 27756272 )
2016
4
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. ( 26937622 )
2016
5
Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables. ( 25847139 )
2015
6
Concomitant colonic disease (Montreal L3) and re-resectional surgery are predictors of clinical recurrence following ileocolonic resection for Crohn's disease. ( 26291699 )
2015
7
Is proliferative colonic disease presentation changing? ( 23236236 )
2012
8
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. ( 22427959 )
2012
9
The colonic microbiota and colonic disease. ( 22941733 )
2012
10
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. ( 21825842 )
2011
11
Merkel cell carcinoma metastatic to the transverse colon: disease free after six years - cure or just prolonged remission? ( 22070707 )
2011
12
Advanced diagnostic imaging in colonic disease. ( 20190723 )
2010
13
Balsalazide in treating colonic diseases. ( 19708827 )
2009
14
Colonic perforation during barium enema in a patient without known colonic disease: a case report. ( 19918538 )
2009
15
Acute colonic disease: how to image in emergency. ( 17174054 )
2007
16
Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease--a pilot study. ( 17969773 )
2007
17
Colonic perforation at CT colonography in a patient without known colonic disease. ( 16357389 )
2006
18
Death from colonic disease in epidermolysis bullosa dystrophica. ( 16480504 )
2006
19
Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. ( 12702972 )
2003
20
Cerebrospinal fluid polyamine levels in patients with colonic disease. ( 12567356 )
2003
21
Halo sign: useful CT sign for differentiating benign from malignant colonic disease. ( 12662952 )
2003
22
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. ( 16378294 )
2002
23
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. ( 11913411 )
2002
24
Apoptotic colonic disease: a new entity in a primate. ( 11286126 )
2001
25
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. ( 11559652 )
2001
26
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. ( 11595480 )
2001
27
Investigation of colonic disease. ( 11103279 )
2000
28
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. ( 9923929 )
1999
29
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10645182 )
1999
30
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. ( 9443117 )
1998
31
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. ( 9600375 )
1998
32
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10209409 )
1998
33
Diagnosis and treatment of colonic disease in AIDS. ( 9730938 )
1998
34
Cystic fibrosis: CT findings of colonic disease. ( 9494492 )
1998
35
Does sucrase deficiency in black South Africans protect against colonic disease? ( 9449875 )
1998
36
Pattern of colonic disease in lower gastrointestinal bleeding in Jordanian patients: a prospective colonoscopic study. ( 9075759 )
1997
37
Analysis of the predictive value of clinical data in patients with suspected colonic disease. ( 9253234 )
1997
38
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. ( 9412955 )
1997
39
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. ( 9106695 )
1997
40
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. ( 9150951 )
1997
41
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. ( 8942726 )
1996
42
A prospective study of abdominal computerized tomography and colonoscopy in the diagnosis of colonic disease in an elderly population. ( 8889456 )
1996
43
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. ( 8587011 )
1995
44
Expression of binding of plasminogen, thrombospondin, vitronectin, and fibrinogen, and adhesive properties by Escherichia coli strains isolated from patients with colonic diseases. ( 7535283 )
1995
45
Glycosylation patterns of mucins in colonic disease. ( 8654850 )
1995
46
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. ( 8099272 )
1993
47
The antegrade colonogram: extending the small bowel follow through for children suspected of having colonic disease. ( 1491931 )
1992
48
Colonic disease in cirrhosis. An endoscopic evaluation in 412 patients. ( 2344925 )
1990
49
Schistosomal colonic disease. ( 2110925 )
1990
50
A morphometric study of the canine colon: comparison of control dogs and cases of colonic disease. ( 2249180 )
1990

Variations for Colonic Disease

Expression for Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for Colonic Disease

GO Terms for Colonic Disease

Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.98 ESR1 PHOX2B SOX10 STAT3 ZEB2
2 negative regulation of apoptotic process GO:0043066 9.97 ASCL1 EDNRB GDNF SOX10 STAT3
3 positive regulation of cell proliferation GO:0008284 9.96 EDN3 EDNRB GDNF NOD2 STAT3
4 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.92 ASCL1 ESR1 GDNF NOD2 PHOX2B SOX10
5 MAPK cascade GO:0000165 9.88 GDNF GFRA1 NRTN RET
6 nervous system development GO:0007399 9.85 ACHE ASCL1 EDNRB GDNF GFRA1 KIDINS220
7 regulation of gene expression GO:0010468 9.84 ASCL1 EDN3 GDNF PHOX2B
8 axon guidance GO:0007411 9.83 GDNF GFRA1 NRTN RET
9 neuron differentiation GO:0030182 9.8 ASCL1 EDN3 PHOX2B RET
10 positive regulation of Notch signaling pathway GO:0045747 9.63 ASCL1 NOD2 STAT3
11 response to pain GO:0048265 9.61 EDNRB RET
12 vasoconstriction GO:0042310 9.61 EDN3 EDNRB
13 glial cell differentiation GO:0010001 9.6 ASCL1 PHOX2B
14 developmental pigmentation GO:0048066 9.59 EDNRB ZEB2
15 peripheral nervous system development GO:0007422 9.58 EDNRB GDNF SOX10
16 sympathetic ganglion development GO:0061549 9.55 ASCL1 PHOX2B
17 melanocyte differentiation GO:0030318 9.54 EDN3 EDNRB SOX10
18 vein smooth muscle contraction GO:0014826 9.51 EDN3 EDNRB
19 noradrenergic neuron development GO:0003358 9.48 ASCL1 PHOX2B
20 posterior midgut development GO:0007497 9.43 EDNRB RET
21 sympathetic nervous system development GO:0048485 9.43 ASCL1 GDNF PHOX2B
22 enteric nervous system development GO:0048484 9.35 EDNRB GDNF PHOX2B RET SOX10
23 neural crest cell migration GO:0001755 9.17 EDN3 EDNRB GDNF NRTN RET SOX10
24 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10.02 ASCL1 EDNRB ESR1 STAT3 ZEB2

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.46 EDN3 GDNF GFRA1 NRTN
2 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.35 ASCL1 ESR1 PHOX2B SOX10 STAT3
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 GDNF GFRA1 NRTN RET

Sources for Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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34 ICD10 via Orphanet
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37 KEGG
38 LifeMap
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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