Aliases & Classifications for Colonic Disease

MalaCards integrated aliases for Colonic Disease:

Name: Colonic Disease 12 14
Colonic Diseases 51 40 41 69
Colon Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5353
MeSH 41 D003108
SNOMED-CT 64 128524007
UMLS 69 C0009373

Summaries for Colonic Disease

MedlinePlus : 40 Your colon, also known as the large intestine, is part of your digestive system. It's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. Many disorders affect the colon's ability to work properly. Some of these include Colorectal cancer Colonic polyps - extra tissue growing in the colon that can become cancerous Ulcerative colitis - ulcers of the colon and rectum Diverticulitis - inflammation or infection of pouches in the colon Irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms Treatment for colonic diseases varies greatly depending on the disease and its severity. Treatment may involve diet, medicines and in some cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Colonic Disease, also known as colonic diseases, is related to megacolon and functional colonic disease, and has symptoms including gastrointestinal gas, nausea and vomiting and icterus. An important gene associated with Colonic Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Bisacodyl and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Colonic Disease

Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 megacolon 28.6 ACHE EDN3 EDNRB GDNF NRTN PHOX2B
2 functional colonic disease 11.9
3 diverticulitis of colon 10.7
4 endometrial clear cell adenocarcinoma 10.4 CTSD ESR1
5 mixed lacrimal gland cancer 10.4 JAK1 STAT3
6 waardenburg syndrome, type 2e 10.3 EDNRB SOX10
7 medullary sponge kidney 10.2 GDNF RET
8 waardenburg syndrome, type 1 10.2 EDN3 SOX10
9 waardenburg syndrome type 4 10.2 EDN3 EDNRB SOX10
10 cochlear disease 10.1 EDN3 EDNRB SOX10
11 intestinal pseudo-obstruction 10.1 EDNRB RET SOX10
12 intestinal disease 10.1 EDNRB NOD2 RET STAT3
13 tietz albinism-deafness syndrome 10.0 EDN3 SOX10
14 constipation 10.0 EDNRB GDNF RET
15 hypoganglionosis 10.0 ACHE GDNF RET
16 waardenburg syndrome, type 4a 10.0 EDN3 EDNRB RET SOX10
17 waardenburg's syndrome 9.9 EDN3 EDNRB RET SOX10
18 multiple endocrine neoplasia, type iia 9.9 GDNF GFRA1 RET
19 autonomic nervous system disease 9.9 ASCL1 EDNRB PHOX2B
20 mowat-wilson syndrome 9.9 EDNRB ZEB2
21 multiple endocrine neoplasia, type iib 9.8 EDNRB GDNF GFRA1 RET
22 thyroid carcinoma, familial medullary 9.7 EDNRB GDNF GFRA1 RET
23 crohn's disease 9.7
24 cholangitis, primary sclerosing 9.5
25 ulcerative colitis 9.5
26 colitis 9.5
27 mucositis 9.5
28 sclerosing cholangitis 9.5
29 cholangitis 9.5
30 goldberg-shprintzen syndrome 9.5 ASCL1 EDN3 EDNRB GDNF RET
31 fibrosis of extraocular muscles, congenital, 1 9.4
32 cystic fibrosis 9.4
33 enterocolitis 9.4
34 aging 9.4
35 autoinflammation with infantile enterocolitis 9.4
36 epidermolysis bullosa dystrophica 9.4
37 hepatitis 9.4
38 familial adenomatous polyposis 9.4
39 inflammatory bowel disease 9.4
40 portal hypertension 9.4
41 epidermolysis bullosa 9.4
42 ischemia 9.4
43 merkel cell carcinoma 9.4
44 perinatal necrotizing enterocolitis 9.4
45 tetraploidy 9.4
46 central hypoventilation syndrome, congenital 9.2 ASCL1 EDN3 EDNRB GDNF PHOX2B RET
47 parkinson disease, late-onset 9.2 ACHE GDNF GFRA1 NRTN
48 intestinal obstruction 9.0 ACHE EDN3 EDNRB GDNF NOD2 NRTN
49 hirschsprung disease 1 6.8 ACHE ASCL1 CTSD EDN3 EDNRB GDNF

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to Colonic Disease

Symptoms & Phenotypes for Colonic Disease

UMLS symptoms related to Colonic Disease:


gastrointestinal gas, nausea and vomiting, icterus, heartburn, dyspepsia, diarrhea, constipation, abdominal pain

GenomeRNAi Phenotypes related to Colonic Disease according to GeneCards Suite gene sharing:

25 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 ZEB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.85 CTSD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.85 ZEB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 CTSD SOX10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.85 STAT3 ZEB2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.85 STAT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 RET
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.85 RET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.85 CTSD
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.85 ZEB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.85 RET
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 ZEB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 RET
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.85 SOX10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 RET
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.85 SOX10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.85 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 RET
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.85 CTSD
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 ZEB2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 SOX10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 CTSD RET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.85 SOX10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.85 STAT3 ZEB2 CTSD RET SOX10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.85 CTSD
28 Decreased Aire reporter expression GR00304-A 9.26 ASCL1 ESR1 SOX10 ZEB2

MGI Mouse Phenotypes related to Colonic Disease:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 SOX10 STAT3 ACHE ASCL1 CTSD EDN3
2 cellular MP:0005384 10.36 ASCL1 CTSD EDNRB ESR1 GDNF GFRA1
3 growth/size/body region MP:0005378 10.32 EDNRB ESR1 GDNF JAK1 KIDINS220 NOD2
4 mortality/aging MP:0010768 10.31 PHOX2B RET SOX10 STAT3 ZEB2 ACHE
5 digestive/alimentary MP:0005381 10.26 CTSD EDN3 EDNRB ESR1 GDNF GFRA1
6 nervous system MP:0003631 10.2 ACHE ASCL1 CTSD EDN3 EDNRB ESR1
7 endocrine/exocrine gland MP:0005379 10.19 ASCL1 CTSD EDNRB ESR1 GDNF JAK1
8 embryo MP:0005380 10.16 EDN3 EDNRB ESR1 GFRA1 PHOX2B RET
9 immune system MP:0005387 10.16 CTSD EDNRB ESR1 GDNF GFRA1 JAK1
10 integument MP:0010771 10.09 ASCL1 CTSD EDN3 EDNRB ESR1 GFRA1
11 craniofacial MP:0005382 10.01 ACHE ASCL1 EDNRB JAK1 STAT3 ZEB2
12 muscle MP:0005369 9.97 GDNF GFRA1 NRTN RET STAT3 ACHE
13 normal MP:0002873 9.86 STAT3 ASCL1 ESR1 GFRA1 JAK1 PHOX2B
14 renal/urinary system MP:0005367 9.7 EDNRB ESR1 GDNF GFRA1 JAK1 RET
15 respiratory system MP:0005388 9.61 JAK1 PHOX2B RET SOX10 STAT3 ACHE
16 vision/eye MP:0005391 9.28 ACHE ASCL1 CTSD EDNRB KIDINS220 NRTN

Drugs & Therapeutics for Colonic Disease

Drugs for Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 922)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisacodyl Approved Phase 4 603-50-9
2
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
3
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
4
Pentoxifylline Approved, Investigational Phase 4,Phase 2 6493-05-6 4740
5
Azathioprine Approved Phase 4,Phase 3 446-86-6 2265
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-23-7 657311 5754
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
9
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
10
Ethiodized oil Approved, Investigational Phase 4,Phase 2 8008-53-5
11
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
12
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
13
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 2 114-07-8 12560
14
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
15
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
16
Tegafur Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7 5386
17
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
18
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
19
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
20
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
21
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
22
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
23
Iodine Approved, Investigational Phase 4,Phase 3,Phase 1 7553-56-2 807
24
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
25
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
26
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
27
Pancrelipase Approved, Investigational Phase 4,Phase 1,Phase 2 53608-75-6
28
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
29
Curcumin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 458-37-7 969516
30
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
32
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
33
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 169590-42-5 2662
34
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2 80621-81-4 6436173
35
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
36
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
37
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
38
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 437-38-7 3345
40
Propofol Approved, Investigational, Vet_approved Phase 4,Early Phase 1 2078-54-8 4943
41
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
42
Amitriptyline Approved Phase 4 50-48-6 2160
43
Perphenazine Approved Phase 4 58-39-9 4748
44 Ramosetron Approved, Investigational Phase 4,Phase 3,Phase 2 132036-88-5
45
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
46
Nitazoxanide Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 55981-09-4 41684
47
Eluxadoline Approved, Investigational Phase 4,Phase 2 864821-90-9
48
Trimebutine Approved Phase 4,Phase 2,Phase 3,Phase 1 39133-31-8
49
Alverine Approved, Investigational Phase 4 150-59-4 3678
50
Mebeverine Approved, Investigational Phase 4 3625-06-7 62887

Interventional clinical trials:

(show top 50) (show all 4905)

# Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach Versus Conventional Approach in Colonic Preparation of Hospitalized Patients Unknown status NCT01853709 Phase 4 Polyethylene glycol (PEG);Bisacodyl
2 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
3 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
4 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
5 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4 VSL#3
6 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
7 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
8 Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome Unknown status NCT02614963 Phase 4 Clostridium Butyricum;placebo
9 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
10 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Unknown status NCT02565550 Phase 4
11 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4 Tiropramide HCl 100mg;Octylonium bromide 20mg
12 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4 pentoxifylline;pentoxifylline placebo
13 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
14 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
15 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
16 A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis Unknown status NCT02425852 Phase 4 Azathioprine;Infliximab;Prednisolone;Hydrocortisone
17 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
18 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
19 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
20 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
21 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Unknown status NCT02557490 Phase 4 oxaliplatin and raltitrexed
22 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Unknown status NCT02354560 Phase 4 Erythromycin
23 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4 Ferrous fumarate;ferric(III)carboxymaltose
24 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
25 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
26 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
27 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
28 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4 polyethylene glycol
29 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
30 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
31 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
32 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
33 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
34 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
35 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
36 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
37 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
38 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
39 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
40 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
41 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4 Ramosetron;Placebo
42 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4 Ramosetron;Placebo
43 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
44 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
45 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4 alosetron
46 EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth Completed NCT00331994 Phase 4 Bacillus clausii;Metronidazole
47 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
48 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
49 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
50 Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders Completed NCT02566876 Phase 4 Mixture of three Bifidobacteria

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: colonic diseases

Genetic Tests for Colonic Disease

Anatomical Context for Colonic Disease

MalaCards organs/tissues related to Colonic Disease:

38
Colon, Liver, Testes, Lung, Breast, T Cells, Skin

Publications for Colonic Disease

Articles related to Colonic Disease:

(show top 50) (show all 88)
# Title Authors Year
1
Reliability of Measuring Ileo-Colonic Disease Activity in Crohn's Disease by Magnetic Resonance Enterography. ( 29361096 )
2018
2
The Growing Utilization of Laparoscopy in Emergent Colonic Disease. ( 29391097 )
2017
3
Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. ( 27672289 )
2016
4
Single-incision versus standard multi-incision laparoscopic colectomy in patients with malignant or benign colonic disease: a systematic review, meta-analysis and assessment of the evidence. ( 27756272 )
2016
5
Advances in colonic disease: some light at the end of the tunnel at the end of the light! ( 26628103 )
2016
6
Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric Crohn's disease. ( 26653943 )
2016
7
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. ( 26937622 )
2016
8
Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables. ( 25847139 )
2015
9
Concomitant colonic disease (Montreal L3) and re-resectional surgery are predictors of clinical recurrence following ileocolonic resection for Crohn's disease. ( 26291699 )
2015
10
The colonic microbiota and colonic disease. ( 22941733 )
2012
11
Is proliferative colonic disease presentation changing? ( 23236236 )
2012
12
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. ( 22427959 )
2012
13
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. ( 21825842 )
2011
14
Merkel cell carcinoma metastatic to the transverse colon: disease free after six years - cure or just prolonged remission? ( 22070707 )
2011
15
Advanced diagnostic imaging in colonic disease. ( 20190723 )
2010
16
Colonic perforation during barium enema in a patient without known colonic disease: a case report. ( 19918538 )
2009
17
Balsalazide in treating colonic diseases. ( 19708827 )
2009
18
Acute colonic disease: how to image in emergency. ( 17174054 )
2007
19
Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease--a pilot study. ( 17969773 )
2007
20
Death from colonic disease in epidermolysis bullosa dystrophica. ( 16480504 )
2006
21
Colonic perforation at CT colonography in a patient without known colonic disease. ( 16357389 )
2006
22
Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. ( 12702972 )
2003
23
Cerebrospinal fluid polyamine levels in patients with colonic disease. ( 12567356 )
2003
24
Halo sign: useful CT sign for differentiating benign from malignant colonic disease. ( 12662952 )
2003
25
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. ( 16378294 )
2002
26
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. ( 11913411 )
2002
27
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. ( 11595480 )
2001
28
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. ( 11559652 )
2001
29
Apoptotic colonic disease: a new entity in a primate. ( 11286126 )
2001
30
Investigation of colonic disease. ( 11103279 )
2000
31
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10645182 )
1999
32
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. ( 9923929 )
1999
33
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. ( 9600375 )
1998
34
Cystic fibrosis: CT findings of colonic disease. ( 9494492 )
1998
35
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10209409 )
1998
36
Diagnosis and treatment of colonic disease in AIDS. ( 9730938 )
1998
37
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. ( 9443117 )
1998
38
Does sucrase deficiency in black South Africans protect against colonic disease? ( 9449875 )
1998
39
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. ( 9412955 )
1997
40
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. ( 9150951 )
1997
41
Pattern of colonic disease in lower gastrointestinal bleeding in Jordanian patients: a prospective colonoscopic study. ( 9075759 )
1997
42
Analysis of the predictive value of clinical data in patients with suspected colonic disease. ( 9253234 )
1997
43
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. ( 9106695 )
1997
44
A prospective study of abdominal computerized tomography and colonoscopy in the diagnosis of colonic disease in an elderly population. ( 8889456 )
1996
45
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. ( 8942726 )
1996
46
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. ( 8587011 )
1995
47
Expression of binding of plasminogen, thrombospondin, vitronectin, and fibrinogen, and adhesive properties by Escherichia coli strains isolated from patients with colonic diseases. ( 7535283 )
1995
48
Glycosylation patterns of mucins in colonic disease. ( 8654850 )
1995
49
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. ( 8099272 )
1993
50
The antegrade colonogram: extending the small bowel follow through for children suspected of having colonic disease. ( 1491931 )
1992

Variations for Colonic Disease

Expression for Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for Colonic Disease

GO Terms for Colonic Disease

Cellular components related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 ESR1 PHOX2B STAT3 ZEB2

Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 ASCL1 EDNRB GDNF SOX10 STAT3
2 positive regulation of cell proliferation GO:0008284 9.95 EDN3 EDNRB GDNF NOD2 STAT3
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.92 ASCL1 ESR1 GDNF NOD2 PHOX2B SOX10
4 regulation of molecular function GO:0065009 9.88 GFRA1 JAK1 NRTN RET
5 nervous system development GO:0007399 9.85 ACHE ASCL1 EDNRB GDNF GFRA1 KIDINS220
6 regulation of gene expression GO:0010468 9.83 ASCL1 EDN3 GDNF PHOX2B
7 MAPK cascade GO:0000165 9.83 GDNF GFRA1 JAK1 NRTN RET
8 axon guidance GO:0007411 9.81 GDNF GFRA1 NRTN RET
9 neuron differentiation GO:0030182 9.8 ASCL1 PHOX2B RET
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.79 JAK1 NRTN RET
11 positive regulation of Notch signaling pathway GO:0045747 9.65 ASCL1 NOD2 STAT3
12 response to pain GO:0048265 9.62 EDNRB RET
13 melanocyte differentiation GO:0030318 9.61 EDNRB SOX10
14 vasoconstriction GO:0042310 9.6 EDN3 EDNRB
15 glial cell differentiation GO:0010001 9.59 ASCL1 PHOX2B
16 developmental pigmentation GO:0048066 9.58 EDNRB ZEB2
17 interleukin-15-mediated signaling pathway GO:0035723 9.57 JAK1 STAT3
18 sympathetic ganglion development GO:0061549 9.54 ASCL1 PHOX2B
19 peripheral nervous system development GO:0007422 9.54 EDNRB GDNF SOX10
20 vein smooth muscle contraction GO:0014826 9.49 EDN3 EDNRB
21 noradrenergic neuron development GO:0003358 9.46 ASCL1 PHOX2B
22 sympathetic nervous system development GO:0048485 9.43 ASCL1 GDNF PHOX2B
23 posterior midgut development GO:0007497 9.4 EDNRB RET
24 enteric nervous system development GO:0048484 9.35 EDNRB GDNF PHOX2B RET SOX10
25 neural crest cell migration GO:0001755 9.1 EDNRB GDNF NRTN RET SOX10 ZEB2

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.72 ASCL1 ESR1 PHOX2B STAT3 ZEB2
2 receptor binding GO:0005102 9.55 EDN3 GDNF GFRA1 JAK1 NRTN
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 ASCL1 ESR1 PHOX2B SOX10 STAT3
4 CCR5 chemokine receptor binding GO:0031730 9.26 JAK1 STAT3
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.02 GDNF GFRA1 JAK1 NRTN RET

Sources for Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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