Aliases & Classifications for Colonic Disease

MalaCards integrated aliases for Colonic Disease:

Name: Colonic Disease 12 14
Colonic Diseases 52 41 42 69
Colon Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5353
MeSH 42 D003108
SNOMED-CT 64 128524007
UMLS 69 C0009373

Summaries for Colonic Disease

MedlinePlus : 41 your colon, also known as the large intestine, is part of your digestive system. it's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. many disorders affect the colon's ability to work properly. some of these include colorectal cancer colonic polyps - extra tissue growing in the colon that can become cancerous ulcerative colitis - ulcers of the colon and rectum diverticulitis - inflammation or infection of pouches in the colon irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms treatment for colonic diseases varies greatly depending on the disease and its severity. treatment may involve diet, medicines and in some cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Colonic Disease, also known as colonic diseases, is related to functional colonic disease and fallopian tube clear cell adenocarcinoma, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colonic Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Prolactin Signaling Pathway. The drugs Bisacodyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and behavior/neurological

Related Diseases for Colonic Disease

Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 functional colonic disease 11.8
2 fallopian tube clear cell adenocarcinoma 10.7 CTSD ESR1
3 bursitis 10.6 JAK1 STAT3
4 megacolon 10.6
5 diverticulitis of colon 10.6
6 deafness, mitochondrial, modifier of 10.4 EDNRB SOX10
7 megalocytic interstitial nephritis 10.4 GDNF RET
8 wallerian degeneration 10.3 EDN3 EDNRB SOX10
9 biliary papillomatosis 10.3 EDN3 EDNRB SOX10
10 waardenburg syndrome, type 3 10.2 EDN3 SOX10
11 sweat gland cancer 10.2 EDNRB GDNF RET
12 mowat-wilson syndrome 10.2 EDNRB ZEB2
13 endometrial clear cell adenocarcinoma 10.1 EDNRB NOD2 RET STAT3
14 hypogonadotropic hypogonadism without anosmia, x-linked 10.1 ACHE GDNF RET
15 diabetes mellitus, noninsulin-dependent, 5 10.0 EDN3 EDNRB RET SOX10
16 autoinflammation with infantile enterocolitis 10.0 ACHE RET
17 nonsyndromic congenital nail disorder 2 10.0 ACHE GFRA1
18 tyrosinemia 10.0 EDN3 EDNRB RET SOX10
19 multiple endocrine neoplasia iib 10.0 GDNF GFRA1 RET
20 melanoma, cutaneous malignant 8 9.9 EDN3 SOX10
21 central hypoventilation syndrome, congenital 9.8 EDNRB GDNF GFRA1 RET
22 medullary thyroid carcinoma, familial 9.7 EDNRB GDNF GFRA1 RET
23 hemopericardium 9.7 ASCL1 EDNRB PHOX2B
24 crohn's disease 9.6
25 ulcerative colitis 9.5
26 colitis 9.5
27 mucositis 9.5
28 sclerosing cholangitis 9.5
29 cholangitis 9.5
30 cystic fibrosis 9.3
31 epidermolysis bullosa dystrophica 9.3
32 hepatitis 9.3
33 familial adenomatous polyposis 9.3
34 inflammatory bowel disease 9.3
35 portal hypertension 9.3
36 epidermolysis bullosa 9.3
37 ischemia 9.3
38 merkel cell carcinoma 9.3
39 tetraploidy 9.3
40 shprintzen-goldberg syndrome 9.2 ASCL1 EDN3 EDNRB GDNF RET
41 parkinson disease, late-onset 9.1 ACHE GDNF GFRA1 NRTN
42 hirschsprung disease 1 8.8 ASCL1 EDN3 EDNRB GDNF PHOX2B RET
43 paralytic ileus 8.8 ACHE EDN3 EDNRB GDNF NOD2 NRTN
44 spinal meningioma 7.9 ACHE EDN3 EDNRB GDNF NRTN PHOX2B
45 myasthenic syndrome, congenital, 21, presynaptic 5.7 ACHE ASCL1 CTSD EDN3 EDNRB GDNF
46 wolffian duct adenocarcinoma 4.8 ACHE ASCL1 CTSD EDN3 EDNRB ESR1

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to Colonic Disease

Symptoms & Phenotypes for Colonic Disease

UMLS symptoms related to Colonic Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Colonic Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 ZEB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.85 CTSD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.85 ZEB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 SOX10 CTSD
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.85 STAT3 ZEB2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.85 STAT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 RET
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.85 RET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.85 CTSD
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.85 ZEB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.85 RET
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 ZEB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 RET
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.85 SOX10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 RET
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.85 SOX10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.85 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 RET
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.85 CTSD
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 ZEB2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 SOX10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 CTSD RET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.85 SOX10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.85 SOX10 STAT3 ZEB2 CTSD RET
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.85 CTSD
28 Decreased Aire reporter expression GR00304-A 9.26 ASCL1 ESR1 SOX10 ZEB2

MGI Mouse Phenotypes related to Colonic Disease:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 ACHE ASCL1 CTSD EDN3 EDNRB ESR1
2 cellular MP:0005384 10.36 KIDINS220 NOD2 PHOX2B RET SOX10 STAT3
3 growth/size/body region MP:0005378 10.32 ACHE ASCL1 CTSD EDNRB ESR1 GDNF
4 mortality/aging MP:0010768 10.31 ACHE ASCL1 CTSD EDN3 EDNRB ESR1
5 digestive/alimentary MP:0005381 10.26 EDNRB ESR1 GDNF GFRA1 NOD2 NRTN
6 nervous system MP:0003631 10.2 ESR1 GDNF GFRA1 KIDINS220 NRTN PHOX2B
7 endocrine/exocrine gland MP:0005379 10.19 ASCL1 CTSD EDNRB ESR1 GDNF JAK1
8 embryo MP:0005380 10.16 EDN3 EDNRB ESR1 GFRA1 PHOX2B RET
9 immune system MP:0005387 10.16 CTSD EDNRB ESR1 GDNF GFRA1 JAK1
10 integument MP:0010771 10.09 ASCL1 CTSD EDN3 EDNRB ESR1 GFRA1
11 craniofacial MP:0005382 10.01 ACHE ASCL1 EDNRB JAK1 STAT3 ZEB2
12 muscle MP:0005369 9.97 GFRA1 NRTN RET STAT3 ACHE EDNRB
13 normal MP:0002873 9.86 STAT3 ASCL1 ESR1 GFRA1 JAK1 PHOX2B
14 renal/urinary system MP:0005367 9.7 EDNRB ESR1 GDNF GFRA1 JAK1 RET
15 respiratory system MP:0005388 9.61 ACHE ASCL1 EDNRB ESR1 JAK1 PHOX2B
16 vision/eye MP:0005391 9.28 EDNRB KIDINS220 NRTN PHOX2B STAT3 ZEB2

Drugs & Therapeutics for Colonic Disease

Drugs for Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 929)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisacodyl Approved Phase 4 603-50-9
2
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
4
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
5
Pentoxifylline Approved, Investigational Phase 4,Phase 2 6493-05-6 4740
6
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
7
Erythromycin Approved, Vet_approved Phase 4,Phase 2 114-07-8 12560
8
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
9
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
10
Tegafur Approved Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7 5386
11
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
12
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
13
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
14
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
15
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
16
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
17
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
18
Azathioprine Approved Phase 4,Phase 2,Phase 3 446-86-6 2265
19
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
20
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
21
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
22
Nitazoxanide Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 55981-09-4 41684
23
Pancrelipase Approved Phase 4,Phase 1,Phase 2 53608-75-6
24
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
25
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
26
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
27
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2 80621-81-4 6436173
28
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
29
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 564-25-0 54671203
30
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
31
Propofol Approved, Investigational, Vet_approved Phase 4,Early Phase 1 2078-54-8 4943
32
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
33
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 437-38-7 3345
35
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
36
Zinc Approved Phase 4 7440-66-6 32051 23994
37
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
38
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128-13-2 31401
39 Ramosetron Approved Phase 4,Phase 3,Phase 2 132036-88-5
40
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
41
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
42
Norepinephrine Approved Phase 4 51-41-2 439260
43
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
44
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
45
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
46
Trimebutine Approved Phase 4,Phase 2,Phase 1 39133-31-8
47
Alverine Approved Phase 4 150-59-4 3678
48 Simethicone Approved Phase 4,Phase 3,Phase 1
49
Histamine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 75614-87-8, 51-45-6 774
50
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764

Interventional clinical trials:

(show top 50) (show all 4846)

id Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach Versus Conventional Approach in Colonic Preparation of Hospitalized Patients Unknown status NCT01853709 Phase 4 Polyethylene glycol (PEG);Bisacodyl
2 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
3 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
4 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
5 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
6 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4 VSL#3
7 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
8 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
9 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
11 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Unknown status NCT02565550 Phase 4
12 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4 Tiropramide HCl 100mg;Octylonium bromide 20mg
13 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4 pentoxifylline;pentoxifylline placebo
14 Probiotic in Irritable Bowel Syndrome (IBS) Patients With Diarrhea Unknown status NCT01667627 Phase 4
15 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
16 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
17 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
18 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
19 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
20 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
21 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4 polyethylene glycol
22 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
23 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
24 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
25 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
26 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
27 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
28 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
29 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
30 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
31 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
32 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4 Ferrous fumarate;ferric(III)carboxymaltose
33 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
34 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
35 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
36 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
37 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
38 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
39 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4 Ramosetron;Placebo
40 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4 Ramosetron;Placebo
41 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
42 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
43 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
44 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4 alosetron
45 EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth Completed NCT00331994 Phase 4 Bacillus clausii;Metronidazole
46 Mesalazine and/or Lactobacillus Casei in the Diverticular Disease of the Colon Completed NCT01534754 Phase 4 Mesalazine plus Lactobacillus casei;Mesalazine placebo plus Lactobacillus casei placebo;Mesalazine 800 mg;Lactobacillus casei
47 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
48 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
49 Mode of Action of Moviprep Completed NCT01622972 Phase 4 Polyethyleneglycol
50 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: colonic diseases

Genetic Tests for Colonic Disease

Anatomical Context for Colonic Disease

MalaCards organs/tissues related to Colonic Disease:

39
Colon, Liver, Testes, Lung, Breast, Kidney, T Cells

Publications for Colonic Disease

Articles related to Colonic Disease:

(show top 50) (show all 86)
id Title Authors Year
1
Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. ( 27672289 )
2016
2
Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric Crohn's disease. ( 26653943 )
2016
3
Single-incision versus standard multi-incision laparoscopic colectomy in patients with malignant or benign colonic disease: a systematic review, meta-analysis and assessment of the evidence. ( 27756272 )
2016
4
Advances in colonic disease: some light at the end of the tunnel at the end of the light! ( 26628103 )
2016
5
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. ( 26937622 )
2016
6
Concomitant colonic disease (Montreal L3) and re-resectional surgery are predictors of clinical recurrence following ileocolonic resection for Crohn's disease. ( 26291699 )
2015
7
Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables. ( 25847139 )
2015
8
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. ( 22427959 )
2012
9
The colonic microbiota and colonic disease. ( 22941733 )
2012
10
Is proliferative colonic disease presentation changing? ( 23236236 )
2012
11
Merkel cell carcinoma metastatic to the transverse colon: disease free after six years - cure or just prolonged remission? ( 22070707 )
2011
12
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. ( 21825842 )
2011
13
Advanced diagnostic imaging in colonic disease. ( 20190723 )
2010
14
Colonic perforation during barium enema in a patient without known colonic disease: a case report. ( 19918538 )
2009
15
Balsalazide in treating colonic diseases. ( 19708827 )
2009
16
Acute colonic disease: how to image in emergency. ( 17174054 )
2007
17
Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease--a pilot study. ( 17969773 )
2007
18
Colonic perforation at CT colonography in a patient without known colonic disease. ( 16357389 )
2006
19
Death from colonic disease in epidermolysis bullosa dystrophica. ( 16480504 )
2006
20
Halo sign: useful CT sign for differentiating benign from malignant colonic disease. ( 12662952 )
2003
21
Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. ( 12702972 )
2003
22
Cerebrospinal fluid polyamine levels in patients with colonic disease. ( 12567356 )
2003
23
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. ( 16378294 )
2002
24
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. ( 11913411 )
2002
25
Apoptotic colonic disease: a new entity in a primate. ( 11286126 )
2001
26
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. ( 11559652 )
2001
27
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. ( 11595480 )
2001
28
Investigation of colonic disease. ( 11103279 )
2000
29
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. ( 9923929 )
1999
30
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10645182 )
1999
31
Cystic fibrosis: CT findings of colonic disease. ( 9494492 )
1998
32
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10209409 )
1998
33
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. ( 9443117 )
1998
34
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. ( 9600375 )
1998
35
Does sucrase deficiency in black South Africans protect against colonic disease? ( 9449875 )
1998
36
Diagnosis and treatment of colonic disease in AIDS. ( 9730938 )
1998
37
Analysis of the predictive value of clinical data in patients with suspected colonic disease. ( 9253234 )
1997
38
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. ( 9106695 )
1997
39
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. ( 9412955 )
1997
40
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. ( 9150951 )
1997
41
Pattern of colonic disease in lower gastrointestinal bleeding in Jordanian patients: a prospective colonoscopic study. ( 9075759 )
1997
42
A prospective study of abdominal computerized tomography and colonoscopy in the diagnosis of colonic disease in an elderly population. ( 8889456 )
1996
43
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. ( 8942726 )
1996
44
Expression of binding of plasminogen, thrombospondin, vitronectin, and fibrinogen, and adhesive properties by Escherichia coli strains isolated from patients with colonic diseases. ( 7535283 )
1995
45
Glycosylation patterns of mucins in colonic disease. ( 8654850 )
1995
46
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. ( 8587011 )
1995
47
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. ( 8099272 )
1993
48
The antegrade colonogram: extending the small bowel follow through for children suspected of having colonic disease. ( 1491931 )
1992
49
Colonic disease in cirrhosis. An endoscopic evaluation in 412 patients. ( 2344925 )
1990
50
Schistosomal colonic disease. ( 2110925 )
1990

Variations for Colonic Disease

Expression for Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for Colonic Disease

GO Terms for Colonic Disease

Cellular components related to Colonic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.8 ESR1 PHOX2B STAT3

Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.99 GDNF GFRA1 JAK1 NRTN RET
2 positive regulation of cell proliferation GO:0008284 9.97 EDN3 EDNRB GDNF NOD2 STAT3
3 negative regulation of apoptotic process GO:0043066 9.97 ASCL1 EDNRB GDNF SOX10 STAT3
4 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.92 ASCL1 ESR1 GDNF NOD2 PHOX2B SOX10
5 regulation of gene expression GO:0010468 9.85 ASCL1 EDN3 GDNF PHOX2B
6 MAPK cascade GO:0000165 9.85 GDNF GFRA1 JAK1 NRTN RET
7 nervous system development GO:0007399 9.85 ACHE ASCL1 EDNRB GDNF GFRA1 KIDINS220
8 axon guidance GO:0007411 9.84 GDNF GFRA1 NRTN RET
9 neuron differentiation GO:0030182 9.81 ASCL1 EDN3 PHOX2B RET
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.79 JAK1 NRTN RET
11 positive regulation of Notch signaling pathway GO:0045747 9.65 ASCL1 NOD2 STAT3
12 response to pain GO:0048265 9.62 EDNRB RET
13 vasoconstriction GO:0042310 9.61 EDN3 EDNRB
14 glial cell differentiation GO:0010001 9.6 ASCL1 PHOX2B
15 developmental pigmentation GO:0048066 9.58 EDNRB ZEB2
16 peripheral nervous system development GO:0007422 9.58 EDNRB GDNF SOX10
17 sympathetic ganglion development GO:0061549 9.56 ASCL1 PHOX2B
18 melanocyte differentiation GO:0030318 9.54 EDN3 EDNRB SOX10
19 vein smooth muscle contraction GO:0014826 9.52 EDN3 EDNRB
20 noradrenergic neuron development GO:0003358 9.49 ASCL1 PHOX2B
21 posterior midgut development GO:0007497 9.43 EDNRB RET
22 sympathetic nervous system development GO:0048485 9.43 ASCL1 GDNF PHOX2B
23 enteric nervous system development GO:0048484 9.35 EDNRB GDNF PHOX2B RET SOX10
24 neural crest cell migration GO:0001755 9.17 EDN3 EDNRB GDNF NRTN RET SOX10

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.62 ASCL1 ESR1 PHOX2B STAT3
2 receptor binding GO:0005102 9.55 EDN3 GDNF GFRA1 JAK1 NRTN
3 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.35 ASCL1 ESR1 PHOX2B SOX10 STAT3
4 CCR5 chemokine receptor binding GO:0031730 9.26 JAK1 STAT3
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.02 GDNF GFRA1 JAK1 NRTN RET

Sources for Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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