Colonic Polyps malady

MedlinePlus: A polyp is an extra piece of tissue that grows inside your body. colonic polyps grow in the large intestine, or colon. most polyps are not dangerous. however, some polyps may turn into cancer or already be cancer. to be safe, doctors remove polyps and test them. polyps can be removed when a doctor examines the inside of the large intestine during a colonoscopy. anyone can get polyps, but certain people are more likely than others. you may have a greater chance of getting polyps if you are over age 50 have had polyps before have a family member with polyps have a family history of colon cancer most colon polyps do not cause symptoms. if you have symptoms, they may include blood on your underwear or on toilet paper after a bowel movement, blood in your stool, or constipation or diarrhea lasting more than a week. nih: national institute of diabetes and digestive diseases²³

MalaCards: Colonic Polyps is related to lynch syndrome and attenuated familial adenomatous polyposis. An important gene associated with Colonic Polyps is RPS8 (ribosomal protein S8), and among its related pathways are Colorectal cancer and Glioblastoma Multiforme. The compounds n-methyl-n-nitrosourea and rofecoxib have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and t cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: A colorectal polyp is a polyp (fleshy growth) occurring on the lining of the colon or rectum. Untreated...⁴⁴ more...

colonic polyps 17 32 23

Diseases related to colonic polyps by text searches and GeneDecks gene sharing:

(show top 50)    (show all 441)

id	Related Disease	Score	Top Affiliating Genes
1	lynch syndrome	31.8	MSH2, MSH6, MLH1
2	attenuated familial adenomatous polyposis	30.8	MSH2, MSH6, APC, PTGS2, CTNNB1
3	gastrointestinal stromal tumor	29.7	CDX2, APC, PTGS2, CTNNB1
4	turcot syndrome	29.7	MSH6, MLH1, APC, CTNNB1
5	peutz-jeghers syndrome	29.3	MUC3A, APC, PTGS2, ODC1, CTNNB1
6	colorectal cancer	28.8	MSH2, MLH1, GSTM1, APC, CCND1
7	anemia	23.8	PCNA, MSH2, MLH1, GSTM1, IL2, APC
8	carcinoma	18.1	PCNA, MUC1, MUC2, MUC3A, CEACAM7, MSH2
9	adenocarcinoma	17.9	PCNA, MUC1, MUC2, MUC3A, CEACAM7, MSH2
10	sebaceous gland neoplasm	13.7	MSH6, MLH1
11	desmoid disease	13.7	APC, CTNNB1
12	small intestine carcinoma	13.6	MSH2, MSH6, MLH1
13	juvenile polyposis syndrome	13.6	APC, PTGS2, CTNNB1
14	muir-torre syndrome	13.6	MSH2, MSH6, MLH1
15	gastritis	13.6	CDX2, MLH1, MGMT
16	gardner syndrome	13.5	APC, CTNNB1
17	cafe-au-lait spots	13.5	MSH2, MSH6, MLH1, APC
18	pseudomyxoma peritonei	13.5	MUC2, CEACAM7, CDX2, APC
19	chronic cholangitis	13.5	MUC2, CDX2
20	alveolar soft part sarcoma	13.5	MSH2, MLH1, APC, CTNNB1
21	microinvasive gastric cancer	13.5	MUC2, JUP, CDX2, MLH1
22	gallbladder disease	13.4	MUC2, CCKBR, COX5A
23	stomach disease	13.4	PTGS2, COX5A
24	pulmonary sclerosing hemangioma	13.4	MUC1, CTNNB1, CTNND1
25	ampulla of vater adenocarcinoma	13.4	MUC1, MUC2, CDX2
26	skin benign neoplasm	13.3	MSH2, MSH6, MLH1, MGMT, ODC1
27	adenocarcinoma in situ	13.3	CEACAM7, CDKN2A, CDX2
28	bowenoid papulosis	13.3	CDKN2A, PTGS2, PPARG
29	hepatic adenoma	13.2	PCNA, APC, CTNNB1
30	tubular adenocarcinoma	13.2	MUC1, MUC2, CDX2, CTNNB1
31	extrahepatic bile duct carcinoma	13.2	MUC2, CDKN2A
32	skin carcinoma	13.2	JUP, GSTM1, KRT8
33	li-fraumeni syndrome	13.2	MSH2, CDKN2A, MLH1
34	bronchiolo-alveolar adenocarcinoma	13.2	MUC2, MUC3A, JUP, CDX2, LOX
35	thyroid cancer, follicular	13.2	APC, CCND1, CTNNB1, PPARG
36	small intestine adenocarcinoma	13.1	MUC1, MUC2, CDX2, APC, CTNNB1
37	thyroid cancer	13.1	APC, DYT10, PPARG
38	endometrial mucinous adenocarcinoma	13.1	MUC1, CDKN2A
39	angiofibroma	13.1	PCNA, JUP, APC, CTNNB1
40	gliosarcoma	13.1	CDKN2A, MGMT, PTGS2
41	cystic teratoma	13.1	MUC2, CDKN2A, CDX2, PTGS2
42	basal cell carcinoma	13.1	JUP, GSTM1, CTNNB1, KRT8
43	atypical teratoid rhabdoid tumor	13.1	MUC1, CCND1, CTNNB1
44	carcinoid syndrome	13.0	MUC1, CDX2, CCKBR, KRT8
45	vitiligo	13.0	MSH2, MSH6, MLH1, GSTM1, PTGS2
46	mucinous cystadenocarcinoma	13.0	PCNA, MUC1, CEACAM7
47	pleomorphic adenoma carcinoma	13.0	CDKN2A, CCND1, CTNNB1
48	stomach carcinoma	13.0	CDKN2A, MLH1, CCND1
49	brain cancer	13.0	MSH2, MSH6, MGMT, APC, ALOX5
50	21-hydroxylase deficiency	13.0	ALPP, KRT8, SLC17A5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to colonic polyps:

²²

MGI Mouse Phenotypes related to colonic polyps:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	GLS
2	endocrine/exocrine gland phenotype	MP:0005379	10.0	CTNND1, IL2, CDX2
3	liver/biliary system phenotype	MP:0005370	9.9	IL2, CCKBR, CCNG1
4	normal phenotype	MP:0002873	9.4	CDX2, GLS, ALPP, IGF1
5	reproductive system phenotype	MP:0005389	9.0	KRT8, CDX2, MLH1, APC, CCND1, ALPP
6	immune system phenotype	MP:0005387	8.8	KRT8, MUC2, MSH2, JUP, IL2, CCND1
7	nervous system phenotype	MP:0003631	8.6	CTNND1, CCND1, NID1, JUP, MSH2, SLC17A5
8	integument phenotype	MP:0010771	8.5	CTNND1, CTNNB1, LOX, CCND1, CCKBR, MLH1
9	hematopoietic system phenotype	MP:0005397	8.5	KRT8, CCND1, APC, PCNA, MSH2
10	behavior/neurological phenotype	MP:0005386	8.2	NID1, PPARG, CTNNB1, GLS, CCKBR, LOX
11	mortality/aging	MP:0010768	8.0	CTNND1, MSH6, JUP, CDX2, MGMT, APC
12	vision/eye phenotype	MP:0005391	7.9	APC, CCND1, PPARG, CTNNB1, CDKN2A, MUC1
13	digestive/alimentary phenotype	MP:0005381	7.1	MSH2, CDKN2A, CDX2, MLH1, IL2, APC
14	cardiovascular system phenotype	MP:0005385	7.1	LOX, IGF1, ALOX5, PTGS2, CTNNB1, PPARG
15	tumorigenesis	MP:0002006	6.6	MLH1, IL2, MGMT, CDX2, CDKN2A, MSH6
16	homeostasis/metabolism phenotype	MP:0005376	5.6	IGF1, FABP1, MUC1, MSH2, MSH6, JUP
17	cellular phenotype	MP:0005384	4.9	ALOX5, PTGS2, ODC1, CTNNB1, CTNND1, PPARG

Articles related to colonic polyps:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Clear cell change in colonic polyps. (18611940)	Eloy C.... Carneiro F.	2009	CTNNB1
2	Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. (18927292)	Melstrom L.G.... Adrian T.A.	2008	ALOX5, LOX
3	Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. (15709190)	Petko Z.... Grady W.M.	2005	MLH1, CDKN2A, MGMT
4	Changes in the expression of the peroxisome proliferator-activated receptor gamma gene in the colonic polyps and colonic mucosa of acromegalic patients. (12915690)	Bogazzi F.... Martino E.	2003	PPARG
5	Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene. (15008240)	Bogazzi F.... Martino E.	2003	PPARG
6	Analysis of cyclin D1 and CDK expression in colonic polyps containing neoplastic foci: a study of proteins extracted from paraffin sections. (12375040)	Izawa H.... Monden M.	2002	CCND1, PCNA, CCNG1
7	Increased levels of promutagenic etheno-DNA adducts in colonic polyps of FAP patients. (10861445)	Schmid K.... Bartsch H.	2000	PTGS2
8	COX-2 inhibitors cut risk of colon polyps. (10948872)		2000	PTGS2
9	Characterization of colonic polyps by two-dimensional gel electrophoresis. (10344285)	Melis R.... White R.	1999	FABP1, COX5A
10	Polymorphism of GSTM1 gene in patients with colorectal cancer and colonic polyps. (10445390)	GawroA8ska-Szklarz B.... Musial H.D.	1999	GSTM1
11	Rectal cancer after sulindac therapy for a sporadic adenomatous colonic polyp. (9820411)	Matsuhashi N.... Yazaki Y.	1998	PTGS2
12	Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. (9843214)	Spirio L.N.... White R.	1998	APC
13	Colon polyps. (9369968)	Watne A.L.	1997	MLH1
14	Immunomodulatory effect of beta-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer. (9290119)	Kazi N.... Mobarhan S.	1997	IL2
15	Acromegaly, colonic polyps and carcinoma. (9302367)	Jenkins P.J.... Besser M.	1997	IGF1
16	Enzymes in intestinal juice from patients with liver diseases and colon polyps: measurement of bilirubin, alkaline phosphatase, aspartate aminotransferase and lactate dehydrogenase. (8727697)	Uno Y.... Yoshida Y.	1996	ALPP, SLC17A5
17	Reduced glutamine content in colonic polyps. (8726301)	Goldin E.... Zimmerman J.	1996	GLS, GLS2
18	Altered mucin core peptide immunoreactivity in the colon polyp-carcinoma sequence. (8859775)	Ho S.B.... Kim Y.S.	1996	MUC1, MUC2, MUC3A
19	The effect of sulindac on colon polyps: circumvention of a transformed phenotype--a hypothesis. (8289454)	Waddell W.R.	1994	DYT10
20	Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies. (1371500)	Ljubimov A.V.... Krutovskikh V.A.	1992	KRT8, NID1
21	Detection and characterization of sucrase-isomaltase in adult human colon and in colonic polyps. (1692546)	Beaulieu J.F.... Quaroni A.	1990	SI

Genes related to colonic polyps according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	RPS8	ribosomal protein S8	11.0	Summaries
2	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0
3	SI	sucrase-isomaltase (alpha-glucosidase)	11.0	Publications
4	CDX2	caudal type homeobox 2	11.0
5	CTNND1	catenin (cadherin-associated protein), delta 1	11.0
6	CCKBR	cholecystokinin B receptor	11.0
7	APC	adenomatous polyposis coli	11.0	Functions, Publications
8	JUP	junction plakoglobin	11.0
9	MSH6	mutS homolog 6 (E. coli)	11.0
10	ODC1	ornithine decarboxylase 1	11.0
11	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
12	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0
13	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
14	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
15	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
16	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
17	GLS2	glutaminase 2 (liver, mitochondrial)	11.0	Publications
18	CCNG1	cyclin G1	11.0	Publications
19	MUC3A	mucin 3A, cell surface associated	11.0	Publications
20	FABP1	fatty acid binding protein 1, liver	11.0	Publications
21	LOX	lysyl oxidase	11.0	Publications
22	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
23	NID1	nidogen 1	11.0	Publications
24	GLS	glutaminase	11.0	Publications
25	KRT8	keratin 8	11.0	Publications
26	COX5A	cytochrome c oxidase subunit Va	11.0	Publications
27	GSTM1	glutathione S-transferase mu 1	11.0	Publications
28	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
29	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
30	ALPP	alkaline phosphatase, placental	11.0	Publications
31	MUC1	mucin 1, cell surface associated	11.0	Publications
32	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
33	IL2	interleukin 2	11.0	Publications
34	CCND1	cyclin D1	11.0	Publications
35	DYT10	dystonia 10	11.0	Publications
36	PCNA	proliferating cell nuclear antigen	11.0	Publications
37	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications

Pathways related to colonic polyps according to GeneDecks:

(show all 21)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.5	MSH6, MSH2
2	Glioblastoma Multiforme36	10.5	APC, MGMT
3	Adhesion3	10.4	JUP, CTNND1
4	Cell adhesion Endothelial cell contacts by junctional mechanisms10	10.1	CTNNB1, JUP, CTNND1
5	D-Glutamine and D-glutamate metabolism20	10.1	GLS, GLS2
6	Busulfan Pathway, Pharmacodynamics34	10.0	MLH1, GSTM1, MSH2, MGMT
7	Cell adhesion_Endothelial cell contacts by junctional mechanisms41	9.9	CTNND1, JUP
8	Termination of O-glycan biosynthesis38	9.8	MUC1, MUC2, MUC3A
9	Endometrial cancer20	9.7	CCND1, CTNNB1, APC, MLH1
10	Pathways in cancer20	9.7	MSH2, MSH6, JUP, CCND1, CTNNB1
11	Thyroid cancer20	9.7	PPARG, CCND1, CTNNB1
12	Mismatch Repair in Eukaryotes36	9.5	PCNA, MSH6, MLH1, MSH2
13	Mismatch repair20	9.5	MLH1, MSH6, PCNA, MSH2
14	DNA damage Role of Brca1 and Brca2 in DNA repair10	9.5	MSH6, MSH2, MLH1, PCNA
15	DNA damage_Role of Brca1 and Brca2 in DNA repair41	9.5	MSH2, MSH6, PCNA, MLH1
16	Colorectal Cancer Metastasis36	9.4	CTNNB1, PTGS2, CCND1, APC, MLH1, MSH6
17	DNA Repair Mechanisms36	9.0	PCNA, MSH2, MGMT, IGF1, MSH6
18	p53 signaling pathway20	9.0	CCND1, CCNG1, IGF1, CDKN2A
19	GADD45 Pathway36	8.8	PCNA, CCND1, CCNG1
20	Pancreatic Adenocarcinoma36	8.4	CCND1, IL2, CCNG1, IGF1, PTGS2, CDKN2A
21	Cell Cycle / Checkpoint Control3	8.3	MGMT, CCND1, MLH1, CDKN2A, MSH6, MSH2

Compounds related to colonic polyps according to GeneDecks:

(show top 50)    (show all 211)

id	Compound	Score	Top Affiliating Genes
1	n-methyl-n-nitrosourea32	10.0	CTNNB1, MGMT, MLH1, MSH6, MSH2
2	rofecoxib32 9 9	11.9	COX5A, PPARG, CCND1
3	glucose32	9.6	MGMT, APC, LOX, CCNG1, GLS, KRT8
4	azoxymethane32	9.6	APC, COX5A, CCND1, ODC1, CTNNB1
5	threonine32	9.6	MSH6, MUC2, CTNND1, KRT8, CCNG1
6	pge232	9.2	PPARG, COX5A, APC, LOX, ALOX5, ODC1
7	arginine32	9.1	MLH1, CCKBR, ALOX5, ALPP, GLS, GLS2
8	h2o232	9.1	ALPP, ODC1, SI, SLC17A5, ALOX5, LOX
9	exisulind32	9.0	CCND1, PPARG, APC, CTNNB1, PTGS2
10	o6-methylguanine32	8.8	MLH1, MSH2, PCNA, MSH6, APC, MGMT
11	curcumin32	8.6	COX5A, CCND1, LOX, MGMT, ALOX5, APC
12	doxorubicin32 34 9 9	11.6	CCNG1, LOX, CCND1, MGMT, MSH6, MLH1
13	temozolomide32 9 9	10.5	PCNA, MSH2, CDKN2A, MLH1, MGMT, IL2
14	biotin32 9 18 9	11.4	PCNA, MUC1, MSH2, CDKN2A, MLH1, CTNNB1
15	sulindac32 9 9	10.4	PCNA, MLH1, APC, CCND1, PTGS2, ODC1
16	5-aza-2deoxycytidine32	8.4	MGMT, CTNNB1, APC, CDX2, JUP, MLH1
17	fatty acid32	8.4	CTNNB1, CDKN2A, LOX, PPARG, COX5A, SI
18	aspirin32 34 18	10.3	APC, MLH1, PCNA, LOX, ALOX5, PTGS2
19	celecoxib32 42 34 9 18 9	13.3	PCNA, APC, CCND1, ALOX5, CTNNB1, PPARG
20	progesterone32 42 9 18 9	12.2	APC, COX5A, CTNNB1, CCND1, PCNA, CEACAM7
21	resveratrol32 9 18 9	11.2	PCNA, CCND1, LOX, PTGS2, PPARG, COX5A
22	crcs32	8.1	MUC1, MUC2, MSH2, MSH6, CDKN2A, MLH1
23	thymidylate32	8.0	CCND1, ODC1, GSTM1, MGMT, MLH1, CDKN2A
24	folate32	7.9	MUC1, CDKN2A, MLH1, MGMT, GSTM1, APC
25	adriamycin32	7.9	CDKN2A, MUC1, CCND1, IGF1, ODC1, CTNNB1
26	n acetylcysteine32	7.9	LOX, SLC17A5, ODC1, ALOX5, CTNNB1, PCNA
27	aspartate32	7.8	GLS, GLS2, SI, SLC17A5, NID1, CTNNB1
28	glutamine32	7.8	SI, GLS2, APC, CCKBR, IGF1, GLS
29	paclitaxel32 34 9 9	10.7	CTNND1, MLH1, JUP, KRT8, CTNNB1, ODC1
30	lactate32	7.5	SI, SLC17A5, KRT8, COX5A, ODC1, GLS2
31	sb 20358032 42	8.4	CCND1, IGF1, ALOX5, ALPP, DYT10, COX5A
32	histamine32 18	8.4	IL2, ALOX5, ODC1, CCKBR, DYT10, CTNND1
33	5fluorouracil32	7.4	PCNA, CTNNB1, CCKBR, IL2, GSTM1, MLH1
34	methotrexate32 34 42 9 9	11.3	MUC1, ODC1, COX5A, GLS, GSTM1, MGMT
35	actinomycin d32	7.1	MUC1, KRT8, ODC1, CEACAM7, IGF1, CCNG1
36	butyrate32	7.0	KRT8, CTNNB1, SI, ALPP, LOX, ODC1
37	thymidine32 18	7.7	CDX2, IGF1, MLH1, MGMT, IL2, CCKBR
38	retinoic acid32 42 18	8.7	ODC1, JUP, CDKN2A, MLH1, DYT10, ALPP
39	cysteine32	6.5	LOX, GLS, CTNNB1, KRT8, COX5A, ALPP
40	tamoxifen32 34 9 9	9.4	IGF1, PCNA, SLC17A5, MUC1, IL2, CCND1
41	estrogen32	6.4	CTNND1, SI, KRT8, COX5A, PPARG, ODC1
42	cycloheximide32	6.3	CEACAM7, IGF1, PTGS2, ODC1, CTNNB1, PPARG
43	paraffin32	6.3	ALPP, ODC1, CTNNB1, KRT8, SI, PCNA
44	testosterone32 9 18 9	9.2	GSTM1, MUC1, PCNA, CDKN2A, ALPP, APC
45	tyrosine32	6.2	CCND1, CCKBR, IL2, SLC17A5, CDX2, CTNND1
46	cisplatin32 34 9 9	8.9	PCNA, MUC1, MSH2, MSH6, SLC17A5, JUP
47	genistein32 9 18 9	8.6	ALOX5, IGF1, CCND1, MGMT, CDKN2A, PCNA
48	dexamethasone32 42 34 9 9	9.4	MUC1, MUC2, JUP, CDKN2A, MGMT, IL2
49	serine32	4.9	KRT8, NID1, COX5A, CTNND1, CTNNB1, ODC1
50	vegf32	4.5	PCNA, ALOX5, LOX, IGF1, CCND1, FABP1

Cellular components related to colonic polyps according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MutSalpha complex	GO:032301	10.2	MSH6, MSH2
2	APC-Axin-1-beta-catenin complex	GO:034742	10.1	CTNNB1, APC
3	lateral plasma membrane	GO:016328	10.1	APC, CTNNB1, JUP
4	cell-cell adherens junction	GO:005913	10.0	CTNNB1, JUP, CTNND1, APC
5	cytosol	GO:005829	7.1	RPS8, PPARG, CTNND1, CTNNB1, CDKN2A, GSTM1

Biological processes related to colonic polyps according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	somatic recombination of immunoglobulin gene segments	GO:016447	10.2	MSH6, MSH2
2	cellular response to organic cyclic compound	GO:071407	9.7	CTNNB1, MGMT, PPARG
3	somatic stem cell maintenance	GO:035019	9.6	CDX2, APC, CDKN2A
4	response to organic nitrogen	GO:010243	9.6	CCND1, CCNG1, PTGS2
5	mismatch repair	GO:006298	9.4	PCNA, MSH2, MSH6
6	response to drug	GO:042493	8.9	MSH2, PPARG, CTNNB1, PTGS2, LOX, CCND1

Molecular functions related to colonic polyps according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	single thymine insertion binding	GO:032143	10.4	MSH6, MSH2
2	oxidized purine DNA binding	GO:032357	10.3	MSH6, MSH2
3	guanine/thymine mispair binding	GO:032137	10.3	MSH2, MSH6
4	mismatched DNA binding	GO:030983	10.2	MSH2, MLH1, MSH6
5	glutaminase activity	GO:004359	10.2	GLS, GLS2
6	cadherin binding	GO:045296	10.2	CTNND1, CTNNB1, APC, JUP
7	single guanine insertion binding	GO:032142	10.1	MSH2, MSH6
8	MutLalpha complex binding	GO:032405	9.6	MSH2, PCNA, MSH6
9	dinucleotide insertion or deletion binding	GO:032139	9.5	PCNA, MSH2
10	enzyme binding	GO:019899	9.3	PTGS2, MSH2, CCND1, PPARG, CTNNB1
11	protein binding	GO:005515	5.0	MSH2, CTNND1, PCNA, CCNG1, CCND1, APC