MCID: CLN006
MIFTS: 31

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Pseudo-Obstruction

MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 52 42 14 69
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3876
MeSH 42 D003112
SNOMED-CT 64 35065006
UMLS 69 C0009377

Summaries for Colonic Pseudo-Obstruction

MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to ogilvie syndrome and hypogonadotropic hypogonadism without anosmia, x-linked. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways is Serotonin Receptor 4/6/7 and NR3C Signaling. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and heart, and related phenotype is nervous system.

Wikipedia : 72 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Colonic Pseudo-Obstruction

Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 ogilvie syndrome 11.5
2 hypogonadotropic hypogonadism without anosmia, x-linked 10.7 ACHE SYP
3 transsexualism 10.6 ACHE BCHE HTR7
4 mediastinal lipomatosis 10.5 BRD4 KANTR
5 glomus tumor 10.4 KIT SYP
6 telangiectatic osteogenic sarcoma 10.4 CALB2 HMBS
7 invasive malignant thymoma 10.4 KIT SYP
8 spinal canal and spinal cord meningioma 10.4 CD40LG KANTR
9 white piedra 10.4 ACHE CD40LG CD59
10 rickettsialpox 10.4 CD40LG KANTR
11 benign epilepsy with centrotemporal spikes 10.4 BRD4 CD40LG HSPG2
12 kidney carcinoma in situ 10.4 CD40LG KANTR
13 superficial basal cell carcinoma 10.4 B2M KIT
14 thrombocytopenia due to platelet alloimmunization 10.4 CD59 KANTR
15 facial nerve neoplasm 10.4 CD40LG KANTR
16 thymus small cell carcinoma 10.4 KIT SYP
17 immune-complex glomerulonephritis 10.3 B2M CD40LG
18 3mc syndrome 10.3 ACHE BCHE KANTR
19 anal colloid adenocarcinoma 10.3 CD40LG KANTR
20 fibrosarcomatous osteosarcoma 10.3 HTR4 MLN MLNR
21 scleral staphyloma 10.3 HTR7 MLN MLNR
22 rocky mountain spotted fever 10.3 CD40LG KANTR
23 olfactory neural tumor 10.3 B2M SYP
24 malignant teratoma 10.3 KIT SYP
25 myositis fibrosa 10.3 HTR4 HTR7 MLN
26 riedel's fibrosing thyroiditis 10.3 KANTR SYP
27 spasmodic dystonia 10.2 B2M KANTR
28 uremia 10.2 CALB2 SYP
29 encephalitozoonosis 10.2 KIT SYP
30 marfanoid habitus-inguinal hernia-advanced bone age syndrome 10.2 CALB2 KIT
31 perianal hematoma 10.2 KANTR MLN
32 sublingual gland adenoid cystic carcinoma 10.2 CALB2 KIT
33 sebaceous adenoma 10.2 KIT SYP
34 tuberculum sellae meningioma 10.2 CD40LG HTR4 MLN
35 diffuse alopecia areata 10.2 KANTR SYP
36 malignant sertoli-leydig cell tumor 10.1 CALB2 KIT
37 proliferative type fibrocystic change of breast 10.1 CALB2 SYP
38 hypolipoproteinemia 10.1 BRD4 CD40LG KANTR
39 adrenal gland disease 10.1 B2M CD40LG
40 maxillary sinus cancer 10.1 KANTR KCNMA1
41 pancreatic agenesis 10.1 KIT SYP
42 sphenoid sinus squamous cell carcinoma 10.1 CALB2 KIT
43 herpes zoster 10.1
44 nutritional optic neuropathy 10.0 HTR4 KANTR MLN
45 diffuse lipomatosis 10.0 PTCRA SYP
46 abnormal pupillary function 10.0 ACHE HTR7 PTCRA
47 prostate carcinoma in situ 10.0 ACHE BCHE CD40LG KANTR
48 theileriasis 10.0 B2M PTCRA
49 peritoneal benign neoplasm 9.9 KANTR KIT SYP
50 burns 9.9

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction

Symptoms & Phenotypes for Colonic Pseudo-Obstruction

MGI Mouse Phenotypes related to Colonic Pseudo-Obstruction:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.36 HTR4 HTR7 KCNMA1 KIT SYP ACHE

Drugs & Therapeutics for Colonic Pseudo-Obstruction

Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 3,Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
2 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002) Completed NCT01553747 Phase 3 JNJ-27018966
3 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001) Completed NCT01553591 Phase 3 JNJ-27018966;Placebo
4 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2 JNJ-27018966;Placebo

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

Genetic Tests for Colonic Pseudo-Obstruction

Anatomical Context for Colonic Pseudo-Obstruction

MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

39
Colon, Kidney, Heart, Brain

Publications for Colonic Pseudo-Obstruction

Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 207)
id Title Authors Year
1
An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction. ( 28620506 )
2017
2
Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. ( 28852322 )
2017
3
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 28228208 )
2017
4
Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis. ( 28386273 )
2017
5
Acute colonic pseudo-obstruction associated with abdominal paracentesis. ( 28069781 )
2017
6
Postpartum Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome): A systematic review of case reports and case series. ( 28531835 )
2017
7
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
8
Clinical Practice Guidelines for Colon Volvulus and Acute Colonic Pseudo-Obstruction. ( 27270510 )
2016
9
Acute Colonic Pseudo-obstruction: Defining the Epidemiology, Treatment, and Adverse Outcomes of Ogilvie's Syndrome. ( 26874130 )
2016
10
Disseminated visceral varicella zoster virus presenting with the constellation of colonic pseudo-obstruction, acalculous cholecystitis and syndrome of inappropriate ADH secretion. ( 26899893 )
2016
11
Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. ( 26947418 )
2016
12
Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. ( 26907487 )
2016
13
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with caecal perforation after caesarean section. ( 27554827 )
2016
14
Hypokalemia associated with acute colonic pseudo-obstruction in an ESRD patient. ( 28025959 )
2016
15
Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation. ( 26424041 )
2015
16
Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( 25912627 )
2015
17
Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome) Following Total Laparoscopic Hysterectomy. ( 26164536 )
2015
18
Acute Colonic Pseudo-obstruction Caused by Acute Gastroenteritis: A Case Report. ( 27398711 )
2015
19
Gastric-type extremely well-differentiated adenocarcinoma arising in the blind pouch of a bypassed stomach, presenting as colonic pseudo-obstruction. ( 26424554 )
2015
20
Images in clinical medicine. Acute colonic pseudo-obstruction. ( 25607448 )
2015
21
Giant colonic volvulus due to colonic pseudo-obstruction. ( 25716038 )
2015
22
Acute colonic pseudo-obstruction in pregnancy. ( 26044983 )
2015
23
Ogilvie's syndrome-acute colonic pseudo-obstruction. ( 25770746 )
2015
24
Hypokalemia Associated with Colonic Pseudo-Obstruction (Ogilvie's Syndrome). ( 26120577 )
2015
25
The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response: a study based on a multicenter database in Korea. ( 24851028 )
2014
26
Acute Colonic Pseudo-Obstruction Caused by Mycophenolate Mofetil in a Kidney Transplant Recipient. ( 24918432 )
2014
27
Recurrence of acute colonic pseudo-obstruction post-caesarean section: a case report. ( 24593760 )
2014
28
Neostigmine for acute colonic pseudo-obstruction: A meta-analysis. ( 25568788 )
2014
29
Intestinal neuronal displasia in a patient with chronic colonic pseudo-obstruction. ( 25091184 )
2014
30
Acute colonic pseudo-obstruction after hysterectomy in a patient with Friedreich ataxia. ( 24346123 )
2013
31
Treatment of Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome). Systematic Review. ( 24281995 )
2013
32
On colonoscopy in acute colonic pseudo obstruction. ( 23831185 )
2013
33
Ogilvie's syndrome (acute colonic pseudo-obstruction) after caesarean section. ( 23552546 )
2013
34
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. ( 24557975 )
2013
35
Acute colonic pseudo-obstruction following allogeneic stem cell transplantation successfully treated by neostigmine. ( 23826585 )
2013
36
Acute colonic pseudo-obstruction (Ogilvie's syndrome) mimicking pneumoperitoneum. ( 24190158 )
2013
37
Neostigmine to relieve a suspected colonic pseudo-obstruction in a burn patient: a case-based review of the literature. ( 23359843 )
2013
38
The role of fentanyl in refractory opioid-related acute colonic pseudo-obstruction. ( 23369542 )
2013
39
Multiple successful emergent peristomal bowel resections under regional anesthesia in a patient with colonic pseudo-obstruction and severe chronic obstructive pulmonary disease. ( 23317608 )
2013
40
Acute colonic pseudo-obstruction (Ogilvie syndrome) in progressive supranuclear palsy. ( 22902091 )
2013
41
Intravenous neostigmine for postoperative acute colonic pseudo-obstruction. ( 22388328 )
2012
42
Acute colonic pseudo-obstruction complicating chemotherapy in paediatric oncohaematological patients: clinical and imaging features. ( 21828148 )
2012
43
Celiac disease presenting as acute colonic pseudo-obstruction. ( 22919868 )
2012
44
Favorable surgical treatment outcomes for chronic constipation with features of colonic pseudo-obstruction. ( 22969211 )
2012
45
Advances and challenges in the management of acute colonic pseudo-obstruction (ogilvie syndrome). ( 23449274 )
2012
46
Hand-assisted laparoscopic subtotal colectomy with cecorectal anastomosis for chronic idiopathic colonic pseudo-obstruction: report of a case. ( 23203769 )
2012
47
Does neostigmine improve time to resolution of symptoms in acute colonic pseudo-obstruction? ( 22985773 )
2012
48
Acute colonic pseudo-obstruction in acromegalic patient with dolicho-megacolon mimicking colonic volvulus. ( 22798128 )
2012
49
Massive acute colonic pseudo-obstruction successfully managed with conservative therapy in a patient with cerebral palsy. ( 21559070 )
2011
50
Colonic pseudo-obstruction (Ogilvie's syndrome) evolving into cecal bascule. ( 21986748 )
2011

Variations for Colonic Pseudo-Obstruction

Expression for Colonic Pseudo-Obstruction

Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.

Pathways for Colonic Pseudo-Obstruction

Pathways related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 9.9 HTR4 HTR7

GO Terms for Colonic Pseudo-Obstruction

Cellular components related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 ACHE B2M CD40LG CD59 KIT

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled serotonin receptor activity GO:0004993 9.16 HTR4 HTR7
2 cholinesterase activity GO:0004104 8.96 ACHE BCHE
3 acetylcholinesterase activity GO:0003990 8.62 ACHE BCHE

Sources for Colonic Pseudo-Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....