MCID: CLN006
MIFTS: 36

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Pseudo-Obstruction

MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 51 41 14 69
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3876
MeSH 41 D003112
SNOMED-CT 64 35065006
UMLS 69 C0009377

Summaries for Colonic Pseudo-Obstruction

MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to constipation and ogilvie syndrome. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways is Serotonin Receptor 4/6/7 and NR3C Signaling. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and heart, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 72 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Colonic Pseudo-Obstruction

Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 constipation 29.5 HTR4 KIT MLN MLNR SST
2 ogilvie syndrome 11.6
3 hypoganglionosis 10.5 ACHE SYP
4 cutaneous ganglioneuroma 10.3 KIT SYP
5 mixed type thymoma 10.3 KIT SYP
6 diffuse lipomatosis 10.3 BRD4 KANTR
7 malignant glandular tumor of peripheral nerve sheath 10.3 SST SYP
8 adenoma of the pancreas 10.3 SST SYP
9 pancreatic somatostatinoma 10.3 SST SYP
10 polyneuropathy 10.3 ACHE CD40LG CD59
11 hyperglobulinemic purpura 10.3 BRD4 CD40LG HSPG2
12 pancreatic endocrine carcinoma 10.3 SST SYP
13 inverted follicular keratosis 10.3 CALB2 HMBS
14 adenoid basal cell carcinoma 10.3 B2M KIT
15 trench fever 10.3 CD40LG KANTR
16 cerebral arteritis 10.2 CD40LG KANTR
17 endometrial small cell carcinoma 10.2 KIT SYP
18 geniculate herpes zoster 10.2 CD40LG KANTR
19 facial hemiatrophy 10.2 CD40LG KANTR
20 yellow nail syndrome 10.2 CD40LG SST
21 agraphia 10.2 ACHE BCHE KANTR
22 brachial plexus neuritis 10.2 CD40LG KANTR
23 pituitary-dependent cushing's disease 10.2 CD59 HTR4 SST
24 binswanger's disease 10.2 ACHE SST SYP
25 herpes zoster 10.2
26 irritable bowel syndrome 10.2 HTR4 HTR7 MLN
27 japanese spotted fever 10.2 CD40LG KANTR
28 mediastinal cancer 10.2 KIT SYP
29 laryngeal tuberculosis 10.1 CD59 KANTR
30 ovarian fibrothecoma 10.1 CALB2 KIT
31 dental abscess 10.1 KANTR KIT
32 oculogyric crisis 10.1 B2M KANTR
33 ovarian melanoma 10.1 CALB2 KIT
34 venous hemangioma 10.1 CALB2 SYP
35 malignant leydig cell tumor 10.1 CALB2 KIT
36 postencephalitic parkinson disease 10.1 KANTR SYP
37 angiomyoma 10.0 KIT SYP
38 burns 10.0
39 diarrhea 10.0
40 hypokalemia 10.0
41 branch retinal artery occlusion 10.0 B2M CD40LG KANTR
42 organ system benign neoplasm 10.0 KIT SST SYP
43 merkel cell carcinoma 10.0 KIT SST SYP
44 rete testis adenocarcinoma 10.0 CALB2 KIT
45 diffuse glomerulonephritis 10.0 B2M CD40LG
46 rumination disorder 10.0 ACHE HTR7 PTCRA
47 pancreatic serous cystadenoma 10.0 PTCRA SYP
48 nervous system disease 10.0 ACHE BCHE CD40LG KANTR
49 mucinous ovarian cystadenoma 10.0 CALB2 SYP
50 small cell cancer of the lung 9.9 KIT SST SYP

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction

Symptoms & Phenotypes for Colonic Pseudo-Obstruction

MGI Mouse Phenotypes related to Colonic Pseudo-Obstruction:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ACHE CALB2 HMBS HSPG2 HTR4 HTR7
2 mortality/aging MP:0010768 9.73 ACHE B2M BCHE CD40LG CD59 HMBS
3 nervous system MP:0003631 9.4 ACHE B2M CALB2 CD40LG HMBS HSPG2

Drugs & Therapeutics for Colonic Pseudo-Obstruction

Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 3,Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
2 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002) Completed NCT01553747 Phase 3 JNJ-27018966
3 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001) Completed NCT01553591 Phase 3 JNJ-27018966;Placebo
4 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2 JNJ-27018966;Placebo
5 Therapeutic Oxygen for Gastrointestinal Atony (TOGA) Recruiting NCT03386136 Phase 1 100% Oxygen

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

Genetic Tests for Colonic Pseudo-Obstruction

Anatomical Context for Colonic Pseudo-Obstruction

MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

38
Colon, Kidney, Heart, Brain

Publications for Colonic Pseudo-Obstruction

Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 210)
# Title Authors Year
1
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. ( 29359574 )
2018
2
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 29428026 )
2018
3
An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction. ( 28620506 )
2017
4
Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. ( 28852322 )
2017
5
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
6
Postpartum Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome): A systematic review of case reports and case series. ( 28531835 )
2017
7
Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis. ( 28386273 )
2017
8
Acute colonic pseudo-obstruction associated with abdominal paracentesis. ( 28069781 )
2017
9
A Rare Cause of Acute Colonic Pseudo-obstruction: Ogilvie's Syndrome Caused by Herpes Zoster. ( 28992679 )
2017
10
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 28228208 )
2017
11
Disseminated visceral varicella zoster virus presenting with the constellation of colonic pseudo-obstruction, acalculous cholecystitis and syndrome of inappropriate ADH secretion. ( 26899893 )
2016
12
Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. ( 26907487 )
2016
13
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with caecal perforation after caesarean section. ( 27554827 )
2016
14
Acute Colonic Pseudo-obstruction: Defining the Epidemiology, Treatment, and Adverse Outcomes of Ogilvie's Syndrome. ( 26874130 )
2016
15
Clinical Practice Guidelines for Colon Volvulus and Acute Colonic Pseudo-Obstruction. ( 27270510 )
2016
16
Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. ( 26947418 )
2016
17
Hypokalemia associated with acute colonic pseudo-obstruction in an ESRD patient. ( 28025959 )
2016
18
Ogilvie's syndrome-acute colonic pseudo-obstruction. ( 25770746 )
2015
19
Acute colonic pseudo-obstruction in pregnancy. ( 26044983 )
2015
20
Acute Colonic Pseudo-obstruction Caused by Acute Gastroenteritis: A Case Report. ( 27398711 )
2015
21
Hypokalemia Associated with Colonic Pseudo-Obstruction (Ogilvie's Syndrome). ( 26120577 )
2015
22
Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome) Following Total Laparoscopic Hysterectomy. ( 26164536 )
2015
23
Giant colonic volvulus due to colonic pseudo-obstruction. ( 25716038 )
2015
24
Images in clinical medicine. Acute colonic pseudo-obstruction. ( 25607448 )
2015
25
Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( 25912627 )
2015
26
Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation. ( 26424041 )
2015
27
Gastric-type extremely well-differentiated adenocarcinoma arising in the blind pouch of a bypassed stomach, presenting as colonic pseudo-obstruction. ( 26424554 )
2015
28
Recurrence of acute colonic pseudo-obstruction post-caesarean section: a case report. ( 24593760 )
2014
29
Acute Colonic Pseudo-Obstruction Caused by Mycophenolate Mofetil in a Kidney Transplant Recipient. ( 24918432 )
2014
30
Neostigmine for acute colonic pseudo-obstruction: A meta-analysis. ( 25568788 )
2014
31
Intestinal neuronal displasia in a patient with chronic colonic pseudo-obstruction. ( 25091184 )
2014
32
The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response: a study based on a multicenter database in Korea. ( 24851028 )
2014
33
The role of fentanyl in refractory opioid-related acute colonic pseudo-obstruction. ( 23369542 )
2013
34
Acute colonic pseudo-obstruction (Ogilvie syndrome) in progressive supranuclear palsy. ( 22902091 )
2013
35
Acute colonic pseudo-obstruction following allogeneic stem cell transplantation successfully treated by neostigmine. ( 23826585 )
2013
36
Treatment of Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome). Systematic Review. ( 24281995 )
2013
37
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. ( 24557975 )
2013
38
Acute colonic pseudo-obstruction after hysterectomy in a patient with Friedreich ataxia. ( 24346123 )
2013
39
On colonoscopy in acute colonic pseudo obstruction. ( 23831185 )
2013
40
Ogilvie's syndrome (acute colonic pseudo-obstruction) after caesarean section. ( 23552546 )
2013
41
Neostigmine to relieve a suspected colonic pseudo-obstruction in a burn patient: a case-based review of the literature. ( 23359843 )
2013
42
Acute colonic pseudo-obstruction (Ogilvie's syndrome) mimicking pneumoperitoneum. ( 24190158 )
2013
43
Multiple successful emergent peristomal bowel resections under regional anesthesia in a patient with colonic pseudo-obstruction and severe chronic obstructive pulmonary disease. ( 23317608 )
2013
44
Advances and challenges in the management of acute colonic pseudo-obstruction (ogilvie syndrome). ( 23449274 )
2012
45
Acute colonic pseudo-obstruction complicating chemotherapy in paediatric oncohaematological patients: clinical and imaging features. ( 21828148 )
2012
46
Does neostigmine improve time to resolution of symptoms in acute colonic pseudo-obstruction? ( 22985773 )
2012
47
Acute colonic pseudo-obstruction in acromegalic patient with dolicho-megacolon mimicking colonic volvulus. ( 22798128 )
2012
48
Intravenous neostigmine for postoperative acute colonic pseudo-obstruction. ( 22388328 )
2012
49
Celiac disease presenting as acute colonic pseudo-obstruction. ( 22919868 )
2012
50
Hand-assisted laparoscopic subtotal colectomy with cecorectal anastomosis for chronic idiopathic colonic pseudo-obstruction: report of a case. ( 23203769 )
2012

Variations for Colonic Pseudo-Obstruction

Expression for Colonic Pseudo-Obstruction

Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.

Pathways for Colonic Pseudo-Obstruction

Pathways related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 HTR4 HTR7

GO Terms for Colonic Pseudo-Obstruction

Cellular components related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 ACHE B2M CD40LG CD59 KIT
2 extracellular space GO:0005615 9.23 ACHE B2M BCHE CD40LG CD59 HSPG2

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholinesterase activity GO:0004104 8.96 ACHE BCHE
2 acetylcholinesterase activity GO:0003990 8.62 ACHE BCHE

Sources for Colonic Pseudo-Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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