MCID: CLR023
MIFTS: 73

Colorectal Cancer malady

Cancer diseases category

Summaries for Colorectal Cancer

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

MalaCards: Colorectal Cancer, also known as colorectal carcinoma, is related to breast cancer and lynch syndrome. An important gene associated with Colorectal Cancer is MCC (mutated in colorectal cancers), and among its related pathways are Colorectal Cancer Metastasis and Pathways in cancer. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and colon, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

Description from OMIM:46 114500

Aliases & Classifications for Colorectal Cancer

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Sources:
63Wikipedia, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

colorectal cancer 63 46 10 44 33 60
colorectal carcinoma 44 60


Related Diseases for Colorectal Cancer

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Colorectal Cancer family:

Familial Colorectal Cancer Colorectal Cancer 6
Colorectal Cancer 2 Colorectal Cancer 1
Colorectal Cancer 5 Colorectal Cancer 7
Colorectal Cancer 12 Colorectal Cancer 8
Colorectal Cancer 4 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.5CCND1, CTNNB1, BAX, MSH6, TP53
2lynch syndrome31.5PMS2, MSH6
3colon cancer31.4CCND1, BRAF, CTNNB1, PPARD, BAX, AXIN2
4adenoma31.3TLR4, BRAF, CCND1, PMS2, CTNNB1, PPARD
5hepatitis31.3TLR2
6lung cancer31.1CCND1, BRAF, TLR4, BAX, MCC, SMAD7
7ulcerative colitis31.0TP53
8familial adenomatous polyposis31.0TP53, MSH6, PLA2G2A, MCC, AXIN2, PPARD
9prostate cancer30.9CTNNB1, PDGFRL, CCND1, PMS2, PMS1, PPARD
10peritonitis30.9TLR2
11adenocarcinoma30.8PMS2, CCND1, BRAF, CTNNB1, BAX, PLA2G2A
12inflammatory bowel disease30.8SMAD7, PLA2G2A, TLR2, TLR4
13ovarian cancer30.8PMS2, CCND1, BRAF, CTNNB1, BAX, MSH6
14melanoma30.8PMS1, PMS2, CCND1, BRAF, TLR4, CTNNB1
15pancreatic cancer30.8CCND1, BRAF, CTNNB1, BAX, PLA2G2A, SMAD7
16pancreatitis30.7PLA2G2A
17leukemia30.5TP53, PLA2G2A, BAX, TLR2, TLR4, CCND1
18esophageal cancer30.5CCND1, TP53
19hepatocellular carcinoma30.4CCND1, TLR4, TLR2, CTNNB1, PPARD, BAX
20hepatitis c30.4TLR2, TLR4
21retinoblastoma30.4PMS1, CCND1, BAX, SMAD7, TP53
22endometrial carcinoma30.4BRAF, CTNNB1, TP53
23muir-torre syndrome30.3MSH6
24stomach cancer30.3TP53
25squamous cell carcinoma30.3PMS1, CCND1, CTNNB1, PPARD, MT-CO1, BAX
26gastritis30.3TP53, TLR2, TLR4
27myeloid leukemia30.3BAX, TLR4
28lung adenocarcinoma30.1CCND1, BRAF, CTNNB1, BAX, TP53
29ischemia30.1PLA2G2A, BAX, MT-CO1
30colon adenocarcinoma30.1CTNNB1, BAX, SMAD7
31thyroid cancer30.1TP53, BRAF, CCND1
32cholangiocarcinoma30.1BRAF, TP53
33turcot syndrome30.1PMS2, MSH6
34peutz-jeghers syndrome30.1CTNNB1, PMS1
35sarcoma30.1BRAF, TP53
36rhabdomyosarcoma30.1TP53
37neuroblastoma30.1TP53
38leiomyosarcoma30.1TP53
39glioblastoma multiforme29.9PMS2, CCND1, TLR4, BAX, TP53
40gallbladder cancer29.9TP53
41non-small cell lung carcinoma29.9TP53, BAX, BRAF, CCND1
42cervical cancer29.9BRAF, BAX, TP53
43astrocytoma29.9PLA2G2A, TP53
44acute pancreatitis29.9PLA2G2A, TLR4
45diabetes mellitus29.9PPARD
46papilloma29.9TP53
47myocardial infarction29.9PPARD
48pneumonia29.9TLR2, TLR4
49hepatitis b29.9TLR4
50vascular cancer11.0

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Clinical Features for Colorectal Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

114500

Clinical synopsis from OMIM:

114500

Drugs & Therapeutics for Colorectal Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colorectal Cancer

Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Search CenterWatch for Colorectal Cancer

Genetic Tests for Colorectal Cancer

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Anatomical Context for Colorectal Cancer

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32MalaCards
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MalaCards organs/tissues related to Colorectal Cancer:

32
Liver, Breast, Colon, Endothelial, Testes, Lymph node, Lung, Prostate, T cells, Appendix, Bone, Brain, Monocytes, Bone marrow, Myeloid, Thyroid, Testis, Skin, Whole blood, Pancreas, Nk cells, Cervix, Kidney, Placenta, Eye, Small intestine, Smooth muscle, Pituitary, B cells, Heart, Fetal liver

Animal Models for Colorectal Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colorectal Cancer:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538413.9TLR2, TLR4, BRAF, CCND1, PMS2, CTNNB1
2MP:001076813.9TLR2, TLR4, BRAF, CCND1, PMS2, CTNNB1
3MP:000200613.7TP53, PMS1, PMS2, CCND1, BRAF, TLR4
4MP:000538713.4PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
5MP:000538613.0CCND1, BRAF, TLR4, TLR2, CTNNB1, PPARD
6MP:000538913.0CCND1, BRAF, TLR4, CTNNB1, PPARD, MLH3
7MP:000538112.9PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
8MP:000538512.7CCND1, BRAF, TLR4, TLR2, CTNNB1, MT-CO1
9MP:000536912.6BRAF, TLR4, TLR2, CTNNB1, MT-CO1, BAX
10MP:000537812.6CCND1, BRAF, TLR4, TLR2, CTNNB1, PPARD
11MP:000539112.6CCND1, BRAF, TLR4, CTNNB1, DCC, BAX
12MP:000539712.5PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
13MP:000537912.4PMS2, CCND1, TLR2, MLH3, BAX, AXIN2
14MP:001077112.4CCND1, TLR4, TLR2, CTNNB1, PPARD, SMAD7
15MP:000537612.4PMS2, TLR4, TLR2, PPARD, MT-CO1, MSH6
16MP:000537011.9TLR4, TLR2, CTNNB1, PPARD, TP53, BRAF
17MP:000538811.7CCND1, CTNNB1, BAX, TP53
18MP:000363111.4TLR4, DCC, BAX, AXIN2
19MP:000539011.3CCND1, BAX, AXIN2

Publications for Colorectal Cancer

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50PubMed
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Articles related to Colorectal Cancer:

(show top 50)    (show all 7752)
idTitleAuthorsYear
1
Circulating levels of novel adipocytokines in patients with colorectal cancer. (23474107)
2013
2
Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers? (23434150)
2013
3
Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3. (24127187)
2013
4
Prognostic Value and Clinicopathological Differences of HIFs in Colorectal Cancer: Evidence from Meta-Analysis. (24324596)
2013
5
Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer. (24288256)
2013
6
Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer. (22305465)
2012
7
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells. (22807066)
2012
8
Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate. (22814742)
2012
9
Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features. (22806308)
2012
10
Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer. (21448429)
2011
11
Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening. (20666480)
2010
12
Pretargeted radioimmunoscintigraphy in patients with primary colorectal cancer using a bispecific anticarcinoembryonic antigen CEA X anti-di-diethylenetriaminepentaacetic acid F(ab')2 antibody. (20127959)
2010
13
Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers. (20696052)
2010
14
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. (20619739)
2010
15
p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. (19343039)
2009
16
Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha. (19048623)
2009
17
Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk. (18433468)
2008
18
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. (18621636)
2008
19
GSTM, GSTT and p53 polymorphisms as modifiers of clinical outcome in colorectal cancer. (18630481)
2008
20
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. (17968323)
2008
21
Contribution of common monoallelic MUTYH gene variants in German patients with familial colorectal cancer. (18503156)
2008
22
Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer. (18031946)
2007
23
Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer. (16397020)
2006
24
A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer. (16971666)
2006
25
Fermented wheat germ extract in the supportive therapy of colorectal cancer]. (16255377)
2005
26
Expression of estrogen receptor beta in human colorectal cancer. (14716825)
2004
27
Serum levels of soluble E-selectin in colorectal cancer. (15254658)
2004
28
Effects of low dose aspirin (81 mg) on proliferating cell nuclear antigen and Amaranthus caudatus labeling in normal-risk and high-risk human subjects for colorectal cancer. (15068834)
2004
29
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients. (14760087)
2004
30
Induction of HSF1 expression is associated with sporadic colorectal cancer. (15457556)
2004
31
Detection of disseminated tumour cells in blood and bone marrow samples of patients undergoing hepatic resection for metastasis of colorectal cancer. (12905553)
2003
32
Gynecologic screening in hereditary nonpolyposis colorectal cancer. (14529665)
2003
33
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. (12771929)
2003
34
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. (14522894)
2003
35
Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites. (12610179)
2003
36
Cyclo-oxygenase inhibition in colorectal adenomas and cancer. (14506383)
2003
37
Molecular detection of p16 promoter methylation in the serum of colorectal cancer patients. (12406556)
2002
38
Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer. (12018454)
2002
39
Decreased levels of precursor transforming growth factor beta1 in human colorectal cancer. (11351271)
2001
40
MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non-polyposis colorectal cancer in young patients. (11532035)
2001
41
Significance of vascular endothelial growth factor expression in colorectal cancer]. (11718049)
2001
42
Detection of exon deletions and duplications of the mismatch repair genes in hereditary nonpolyposis colorectal cancer families using multiplex polymerase chain reaction of short fluorescent fragments. (10850409)
2000
43
Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: effect of TP53 or hMLH1 deficiency. (10993958)
2000
44
The role of cathepsins and the plasminogen activator/inhibitor system in colorectal cancer]. (10489782)
1999
45
NM-23 H1 immunohistochemistry is not useful as predictor of metastatic potential of colorectal cancer. (8912537)
1996
46
Failure to increase 5-fluorouracil activity with interferon-alpha 2a in the treatment of advanced colorectal cancer. (7695965)
1995
47
Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues. (8275435)
1994
48
A new approach to tumour marker assessment by perioperative determination in breast and colorectal cancer. (8496629)
1993
49
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate. (1827310)
1991
50
Metastatic colorectal cancer: radioimmunoscintigraphy with a stabilized In-111-labeled F(ab')2 fragment of an anti-CEA monoclonal antibody. (2294542)
1990

Genetic Variations for Colorectal Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Colorectal Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colorectal Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colorectal Cancer

Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 59Tocris Bioscience, 53Reactome, 55SinoBiological
See all sources

Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.9TP53, CCND1, MSH6, AXIN2, BAX, DCC
212.6CCND1, BRAF, CTNNB1, PPARD, DCC, BAX
3
Hide members
12.6MSH6, AXIN2, BAX, DCC, PPARD, CTNNB1
412.2CCND1, BRAF, CTNNB1, BAX, MSH6, SMAD7
511.9CCND1, BRAF, TLR4, TLR2, CTNNB1, TP53
6
Hide members
11.9CCND1, CTNNB1, PPARD, BAX, AXIN2, TP53
7
Hide members
11.7CCND1, TLR4, TLR2, BAX, TP53
8
Hide members
11.7TP53, BAX, TLR2, TLR4, CCND1
9
Hide members
11.7CCND1, BRAF, TLR4, TLR2, BAX
1011.7CCND1, CTNNB1, DCC, BAX, TP53
1111.7CCND1, CTNNB1, AXIN2, SMAD7, TP53
12
Hide members
11.7TP53, AXIN2, PPARD, CTNNB1, CCND1
1311.4TP53, PLA2G2A, TLR4, CCND1
1411.4CCND1, CTNNB1, BAX, TP53
1511.4CCND1, BRAF, CTNNB1, TP53
1611.4TP53, CTNNB1, BRAF, CCND1
17
Hide members
11.4TP53, BAX, CTNNB1, BRAF
18
Hide members
11.4CCND1, BAX, MSH6, TP53
1911.4TP53, PPARD, CTNNB1, CCND1
2011.4SMAD7, AXIN2, CTNNB1, CCND1
21
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11.2CCND1, BAX, TP53
22
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11.2TP53, BAX, CCND1
23
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11.2CCND1, BRAF, TP53
24
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11.2BRAF, BAX, TP53
25
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11.2TLR2, TLR4, BRAF
26
Hide members
11.2TLR2, TLR4, BRAF
2711.2TP53, BAX, PMS2
28
Hide members
11.2TP53, MSH6, BRAF
29
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
11.2BAX, AXIN2, TP53
3011.2AXIN2, CTNNB1, CCND1
3111.2CCND1, CTNNB1, PPARD
32
Hide members
11.2MLH3, PMS2, PMS1
33
Hide members
11.0TLR2, TLR4

Compounds for genes affiliated with Colorectal Cancer

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1vegf4413.3BRAF, CCND1, TLR4, TLR2, CTNNB1, PPARD
2retinoic acid44 2414.1TP53, BRAF, TLR4, CCND1, TLR2, PLA2G2A
3tyrosine4413.0PPARD, CCND1, BRAF, TLR4, SMAD7, CTNNB1
4sb 20358044 5913.9CCND1, BRAF, TLR4, TLR2, BAX, CTNNB1
5cisplatin44 49 59 1115.8CCND1, BRAF, TP53, TLR4, CTNNB1, BAX
6n acetylcysteine4412.6CTNNB1, BAX, SMAD7, TP53, TLR4, CCND1
7ly2940024412.6CTNNB1, TLR4, PLA2G2A, TP53, CCND1, BAX
8paraffin4412.6PMS2, CCND1, BRAF, CTNNB1, BAX, MSH6
9phosphatidylinositol4412.5BAX, CTNNB1, CCND1, TLR4, BRAF, TLR2
10crcs4412.4BRAF, CTNNB1, CCND1, MSH6, TP53, PMS2
11pd 98,0594412.3TLR2, SMAD7, BAX, CTNNB1, BRAF, CCND1
12wortmannin4412.3CTNNB1, TLR2, TLR4, BRAF, CCND1, BAX
13actinomycin d4412.3TLR4, BAX, PLA2G2A, SMAD7, TLR2, TP53
14fatty acid4412.3PLA2G2A, BRAF, TLR2, CTNNB1, PPARD, MT-CO1
15sulindac44 1113.1TP53, BAX, PPARD, CTNNB1, CCND1
16palmitate4412.1PPARD, TLR2, TLR4, CTNNB1, PLA2G2A
17paclitaxel44 49 1114.1BRAF, CCND1, BAX, TP53, CTNNB1
18retinoid4412.1PPARD, BAX, TP53, CTNNB1, CCND1
19serine4412.1CCND1, PLA2G2A, TLR4, TLR2, AXIN2
20doxorubicin44 49 1113.9CCND1, TP53, MSH6, BAX, CTNNB1
21exisulind4411.9PPARD, BAX, CTNNB1, CCND1
22sulindac sulfide4411.9TP53, BAX, PPARD, CCND1
23docosahexaenoic acid44 28 2413.9TLR4, TLR2, PPARD, PLA2G2A
24indole-3-carbinol4411.9BAX, CTNNB1, CCND1, TP53
25c2ceramide4411.8TP53, BAX, TLR4, PLA2G2A
26adpribose4411.8TP53, CTNNB1, CCND1, BAX
27geldanamycin44 49 59 1114.8CTNNB1, BRAF, CCND1, TP53
28sp 60012544 5912.8TP53, TLR2, CCND1, BAX
29gf 109203x44 5912.7TLR2, CCND1, CTNNB1, PLA2G2A
30adriamycin4411.7CCND1, TP53, BAX, CTNNB1
31genistein44 28 59 2 11 2416.7BAX, PLA2G2A, TLR4, CCND1, CTNNB1
32mg 13244 5912.7CTNNB1, TP53, BAX, CCND1
33oligonucleotide4411.6CTNNB1, CCND1, TP53, SMAD7, PPARD, BRAF
34tgf beta14411.6SMAD7, CTNNB1, TLR4, CCND1
35quercetin44 59 11 2414.6PLA2G2A, CTNNB1, BAX, CCND1
36olomoucine44 1112.6BAX, TP53, CCND1
37o6-methylguanine4411.5MSH6, TP53, BRAF
38cetuximab44 49 1113.5CTNNB1, CCND1, BRAF
39depsipeptide4411.4TP53, CCND1
40bbr34644411.3BAX, TP53
41pidotimod4411.3AXIN2, CTNNB1
42inostamycin4411.3BAX, CCND1
43h2o24411.2PLA2G2A, CTNNB1
44arabinogalactan4411.2TLR2, TLR4
45sb-2167634411.2CCND1, CTNNB1
46cycloheximide4411.2TLR2
47dutp4411.1BAX, CCND1, TP53
48chlorophyllin4411.1CCND1, CTNNB1
49mhs-24411.0PMS2, PMS1
50samp4411.0CTNNB1, AXIN2

GO Terms for genes affiliated with Colorectal Cancer

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16Gene Ontology
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Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1PMS1, PMS2, CCND1, BRAF, CTNNB1, PPARD
2mismatch repair complexGO:03230011.3MLH3, PMS2, PMS1
3MutLalpha complexGO:03238911.0PMS2, PMS1
4beta-catenin destruction complexGO:03087711.0AXIN2, CTNNB1
5catenin complexGO:01634210.9CTNNB1, SMAD7

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629811.8MSH6, MLH3, PMS2, PMS1
2reciprocal meiotic recombinationGO:00713111.8PMS1, PMS2, MLH3, MSH6
3ATP catabolic processGO:00620011.8MSH6, MLH3, PMS2, PMS1
4positive regulation of apoptotic processGO:04306511.6CTNNB1, DCC, BAX, TP53
5positive regulation of inflammatory responseGO:05072911.5TLR4, TLR2, PLA2G2A
6intrinsic apoptotic signaling pathwayGO:09719311.5BAX, MSH6, TP53
7regulation of centromeric sister chromatid cohesionGO:07060211.3AXIN2, CTNNB1
8somatic recombination of immunoglobulin gene segmentsGO:01644711.3MSH6, PMS2
9maintenance of DNA repeat elementsGO:04357011.3MSH6, AXIN2
10positive regulation of macrophage cytokine productionGO:06090711.3TLR2, TLR4
11cellular response to lipoteichoic acidGO:07122311.2TLR4, TLR2
12adherens junction assemblyGO:03433311.2CTNNB1, SMAD7
13negative regulation of interleukin-17 productionGO:03270011.2TLR2, TLR4
14positive regulation of protein oligomerizationGO:03246111.2TP53, BAX
15positive regulation of tumor necrosis factor biosynthetic processGO:04253511.2TLR4, TLR2
16mitotic G1 DNA damage checkpointGO:03157111.2CCND1, TP53
17dorsal/ventral axis specificationGO:00995011.1CTNNB1, AXIN2
18positive regulation of nitric-oxide synthase biosynthetic processGO:05177011.1TLR4, TLR2
19somatic hypermutation of immunoglobulin genesGO:01644611.0PMS2, MSH6
20I-kappaB phosphorylationGO:00725211.0TLR4, TLR2
21response to salt stressGO:00965111.0TP53, BAX
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.9BRAF, TLR4, DCC
23determination of adult lifespanGO:00834010.9TP53, MSH6

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.2PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
2ATPase activityGO:01688711.5MSH6, MLH3, PMS2, PMS1
3protein kinase bindingGO:01990111.4TP53, AXIN2, CTNNB1, CCND1
4MutSalpha complex bindingGO:03240711.4MLH3, PMS2, PMS1
5I-SMAD bindingGO:07041111.4SMAD7, AXIN2, CTNNB1
6mismatched DNA bindingGO:03098311.3PMS1, MLH3, MSH6
7enzyme bindingGO:01989911.1CCND1, CTNNB1, AXIN2, TP53
8single-stranded DNA bindingGO:00369711.1MLH3, PMS2, PMS1
9lipopolysaccharide receptor activityGO:00187511.0TLR4, TLR2

Products for genes affiliated with Colorectal Cancer

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Colorectal Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet