MCID: CLR023
MIFTS: 95

Colorectal Cancer malady

Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases categories

Summaries for Colorectal Cancer

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OMIM:47 Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and... (114500) more...

MalaCards based summary: Colorectal Cancer, also known as colon cancer, is related to lynch syndrome and adenoma, and has symptoms including uterine leiomyosarcoma, renal cell carcinoma and hereditary nonpolyposis colorectal carcinoma. An important gene associated with Colorectal Cancer is DCC (deleted in colorectal carcinoma), and among its related pathways are Pathways in cancer and Endometrial cancer. The compounds serine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include the colon, colon and liver, and related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:10 A colorectal cancer that is located in the colon.

MedlinePlus:34 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

Wikipedia:65 Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is the development of... more...

Aliases & Classifications for Colorectal Cancer

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Colorectal Cancer, Aliases & Descriptions:

Name: Colorectal Cancer 47 32 10 65 12 45 34 62
Colon Cancer 47 10 45
Colon Cancer, Somatic 47 11
Colorectal Carcinoma 45 62
Neoplasm of Colon 22 24
 
Colon Carcinoma 10 45
Colonic Adenoma Recurrence, Reduced Risk of 47
Colorectal Cancer, Somatic 47
Carcinoma of Colon 10
Colonic Carcinoma 10


Classifications:



Related Diseases for Colorectal Cancer

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Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 12
Colorectal Cancer 3 Colorectal Cancer 10
Familial Colorectal Cancer

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 468)
idRelated DiseaseScoreTop Affiliating Genes
1lynch syndrome31.8TP53, APC, BRAF, NRAS, MLH3
2adenoma31.6BRAF, AXIN2, TP53, ODC1, CCND1, NRAS
3breast cancer31.1CCND1, TP53
4adenocarcinoma31.1APC, ODC1, CTNNB1, BAX, CCND1, AKT1
5melanoma31.0FGFR3, CTNNB1, BAX, NRAS, CCND1, AKT1
6adenomatous polyposis coli31.0APC, CTNNB1
7lung cancer30.9BAX, TP53, BRAF, CCND1
8endometrial cancer30.8TP53, CTNNB1, BRAF
9colon adenocarcinoma30.8ODC1, CTNNB1, BAX, BUB1B
10leukemia30.8FGFR3, BAX, NRAS, CCND1, AKT1, EP300
11hepatocellular carcinoma30.7PIK3CA, CTNNB1
12prostate cancer30.6ODC1, AKT1, CTNNB1, BAX
13retinoblastoma30.6EP300, TP53, AKT1, CCND1, BAX, FGFR3
14pancreatic cancer30.5CTNNB1, CCND1, AKT1
15stomach cancer30.4CTNNB1, BAX, CCND1, AKT1, EP300, BRAF
16myeloma30.4CCND1, BAX, FGFR3, AKT1
17cholangiocarcinoma30.4BRAF, PIK3CA, NRAS, TP53
18sarcoma30.4ODC1, TP53, BRAF, EP300, NRAS
19mismatch repair cancer syndrome30.4CTNNB1, APC
20neuroblastoma30.4TP53, AKT1
21esophageal cancer30.4CCND1, BAX
22chronic lymphocytic leukemia30.3TP53, CCND1, BAX
23glioblastoma30.1AKT1, CCND1, TP53, PIK3CA, ODC1, BAX
24glioblastoma multiforme30.1TP53, PIK3CA, ODC1, BAX
25mental retardation30.1FGFR3, BRAF, EP300, AKT1
26ataxia-telangiectasia30.1TP53, PIK3CA, BAX
27papilloma30.1ODC1, FGFR3, TP53
28thyroid cancer30.1APC, PIK3CA, PTPRJ, BRAF, FGFR3
29gallbladder cancer30.0TP53, APC, NRAS
30desmoid disease, hereditary30.0APC, CTNNB1
31gastric cancer, somatic30.0APC, PIK3CA
32polyposis, juvenile intestinal30.0APC
33multiple myeloma30.0FGFR3, CCND1
34fibromatosis30.0APC, CTNNB1
35familial colorectal cancer11.1
36endotheliitis11.1
37hepatitis10.9
38colitis10.8
39hypoxia10.8
40ulcerative colitis10.8
41prostatitis10.7
42peritonitis10.7
43inflammatory bowel disease10.7
44transverse colon cancer10.7
45insulin-like growth factor i10.6
46ascending colon cancer10.6
47colorectal adenoma10.6
48pancreatitis10.6
49obesity10.5
50descending colon cancer10.5

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Symptoms for Colorectal Cancer

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Symptoms by clinical synopsis from OMIM:

114500

Clinical features from OMIM:

114500

HPO human phenotypes related to Colorectal Cancer:

id Description Frequency HPO Source Accession
1 uterine leiomyosarcoma HP:0002891
2 renal cell carcinoma HP:0005584
3 hereditary nonpolyposis colorectal carcinoma HP:0006716
4 transitional cell carcinoma of the bladder HP:0006740
5 neoplasm of the stomach HP:0006753

Drugs & Therapeutics for Colorectal Cancer

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Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Genetic Tests for Colorectal Cancer

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Genetic tests related to Colorectal Cancer:

id Genetic test Affiliating Genes
1 Colon Cancer (apc I1307k Related)22 APC
2 Carcinoma of Colon24

Anatomical Context for Colorectal Cancer

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MalaCards organs/tissues related to Colorectal Cancer:

33
Colon, Liver, Breast, Endothelial, Testes, Lymph node, T cells, Lung, Prostate, Bone, Brain, Eye, Kidney, Testis, Myeloid, Bone marrow, Monocytes, Skin, Adipocyte, Whole blood, Neutrophil, Pancreas, Thyroid, Pituitary, Heart, Small intestine, Placenta, Nk cells, B cells, Fetal liver, Appendix

FMA organs/tissues related to Colorectal Cancer:

16
The colon

Animal Models for Colorectal Cancer or affiliated genes

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MGI Mouse Phenotypes related to Colorectal Cancer:

37 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.6DCC, TP53, APC, ODC1, BUB1B, PTPRJ
2MP:000538412.5PIK3CA, AURKA, FGFR3, AXIN2, CTNNB1, BAX
3MP:000200612.3PIK3CA, FGFR3, CTNNB1, NRAS, CCND1, AKT1
4MP:000537812.2TP53, APC, BUB1B, PTPRJ, AURKA, PIK3CA
5MP:000538012.2APC, ODC1, BUB1B, PTPRJ, AURKA, PIK3CA
6MP:000538712.1BRAF, TP53, APC, BUB1B, PTPRJ, PIK3CA
7MP:000537612.1BRAF, TP53, APC, BUB1B, PTPRJ, PIK3CA
8MP:000539112.1PIK3CA, BUB1B, APC, TP53, DCC, BRAF
9MP:000538912.1APC, BUB1B, PTPRJ, MLH3, PIK3CA, TP53
10MP:000538512.0PIK3CA, PTPRJ, BUB1B, APC, TP53, BRAF
11MP:000539712.0PTPRJ, BUB1B, APC, TP53, BRAF, FLCN
12MP:000363111.8BRAF, DCC, TP53, APC, PIK3CA, EP300
13MP:000287311.8TP53, APC, ODC1, PTPRJ, BRAF, AKT1
14MP:000538811.7PTPRJ, TP53, DCC, BRAF, EP300, AKT1
15MP:000536911.7APC, BUB1B, PTPRJ, PIK3CA, TP53, BRAF
16MP:000537911.7PIK3CA, MLH3, APC, TP53, BRAF, AKT1
17MP:000539011.7BRAF, TP53, APC, BUB1B, AKT1, CCND1
18MP:001077111.7TP53, APC, BUB1B, PIK3CA, BRAF, AKT1
19MP:000538611.6PIK3CA, BUB1B, APC, TP53, DCC, BRAF
20MP:000538211.6PTPRJ, APC, TP53, BRAF, EP300, CCND1
21MP:000301211.5PIK3CA, AURKA, PTPRJ, APC, TP53, NRAS
22MP:000538111.5APC, TP53, DCC, BRAF, EP300, CCND1
23MP:000536711.3APC, TP53, BRAF, FLCN, EP300, BAX
24MP:000537111.1APC, TP53, NRAS, BAX, CTNNB1, AXIN2
25MP:000537011.0PTPRJ, APC, TP53, BRAF, AKT1, NRAS
26MP:000118611.0CTNNB1, BRAF, DCC, TP53, APC
27MP:000537510.8PIK3CA, BUB1B, APC, TP53, BRAF, AKT1

Publications for Colorectal Cancer

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Articles related to Colorectal Cancer:

(show top 50)    (show all 7820)
idTitleAuthorsYear
1
The effect of oxoguanine glycosylase 1 rs1052133 polymorphism on colorectal cancer risk in Caucasian population. (23975367)
2014
2
E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells. (24369055)
2013
3
Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. (23797051)
2013
4
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
5
Metachronous colorectal cancer: A competing risks analysis with consideration for a stratified approach to surveillance colonoscopy. (24272767)
2013
6
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing. (24284403)
2013
7
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry. (23745025)
2013
8
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
9
Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. (23226332)
2012
10
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. (23033949)
2012
11
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer. (22699826)
2012
12
Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer. (22351690)
2012
13
Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression. (21806965)
2011
14
Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome. (20584785)
2010
15
BRAF mutation predicts resistance to anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer. (20514492)
2010
16
High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. (19856313)
2010
17
A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. (19616522)
2009
18
Individualized therapies in colorectal cancer: KRAS as a marker for response to EGFR-targeted therapy. (19386128)
2009
19
P53 and EGFR expression in colorectal cancer: a reappraisal of 'old' tissue markers in patients with long follow-up. (19331236)
2009
20
Invasion front-specific overexpression of tissue inhibitor of metalloproteinase-1 in liver metastases from colorectal cancer. (18630499)
2008
21
An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. (17785764)
2008
22
KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors. (19378369)
2008
23
Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. (18419600)
2008
24
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (18381954)
2008
25
Galectin-3 expression in colorectal cancer: relation to invasion and metastasis. (17695516)
2007
26
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
27
Genetic testing in colorectal cancer: who, when, how and why. (17392593)
2007
28
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. (16804544)
2006
29
Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples. (15956025)
2006
30
Expression of maspin in colorectal cancer. (17203770)
2006
31
Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. (16491830)
2005
32
Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. (15041737)
2004
33
High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. (15534108)
2004
34
The role of new agents in the treatment of colorectal cancer. (15031593)
2004
35
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule. (15550581)
2004
36
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. (15355920)
2004
37
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
38
Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. (14968945)
2003
39
Significance of transforming growth factor beta1 as a new tumor marker for colorectal cancer. (11802214)
2002
40
Enhanced 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in human colorectal cancer not expressing low density lipoprotein receptor. (10226581)
1999
41
Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients. (10206298)
1999
42
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. (10490837)
1999
43
Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. (9683794)
1998
44
Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. (9615749)
1998
45
Soluble CD44 and CD44v6 serum levels in patients with colorectal cancer are independent of tumor stage and tissue expression of CD44v6. (9625129)
1998
46
Beta-catenin mutations in cell lines established from human colorectal cancers. (9294210)
1997
47
Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines. (8712692)
1996
48
APC mutation analysis in sporadic colorectal cancer]. (9387290)
1996
49
Colonoscopy in relation to the evolving genetics of familial colorectal cancer. (7601034)
1995
50
Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. (7874129)
1994

Variations for Colorectal Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer:

64 (show all 17)
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052
10PIK3CAp.Arg38HisVAR_026166
11PIK3CAp.Gly106ValVAR_026168
12PIK3CAp.Cys420ArgVAR_026171
13PIK3CAp.Glu453GlnVAR_026172
14PIK3CAp.Glu542LysVAR_026173
15PIK3CAp.Glu545LysVAR_026178
16PIK3CAp.Met1043IleVAR_026190
17PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Colorectal Cancer:

7 (show all 13)
id Gene Variation Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.974G> T (p.Gly325Val)single nucleotide variantPathogenicrs121912659GRCh37Chr 17, 7576872: 7576872
2TP53NM_000546.5(TP53): c.566C> T (p.Ala189Val)single nucleotide variantPathogenicrs121912665GRCh37Chr 17, 7578283: 7578283
3PLA2G2ANM_000300.3(PLA2G2A): c.144_145delTG (p.Cys48Trpfs)deletionPathogenicGRCh37Chr 1, 20304913: 20304914
4PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
5PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
6AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
7MT-CO2m.8009G> Asingle nucleotide variantPathogenicrs199474826GRCh37Chr MT, 8009: 8009
8MT-CO1m.6264G> Asingle nucleotide variantPathogenicrs267606882GRCh37Chr MT, 6264: 6264
9MT-CO1m.6277G> Asingle nucleotide variantPathogenicGRCh37Chr MT, 6277: 6277
10MT-CO1m.7275T> Csingle nucleotide variantPathogenicGRCh37Chr MT, 7275: 7275
11MT-CYBm.14985G> Asingle nucleotide variantPathogenicrs207459995GRCh37Chr MT, 14985: 14985
12MT-CYBm.15572T> Csingle nucleotide variantPathogenicrs207459996GRCh37Chr MT, 15572: 15572
13MT-ND4Lm.10563T> Csingle nucleotide variantPathogenicrs267606892GRCh37Chr MT, 10563: 10563

Cosmic variations for Colorectal Cancer:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1532KRASlarge intestine,colon,other,ulcerative colitis3
2528KRASlarge intestine,colon,other,ulcerative colitis3
3516KRASlarge intestine,colon,other,ulcerative colitis3
4520KRASlarge intestine,colon,other,ulcerative colitis3
5521KRASlarge intestine,colon,other,ulcerative colitis3

Expression for genes affiliated with Colorectal Cancer

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LifeMap Discovery
Genes differentially expressed in tissues of Colorectal Cancer patients vs. healthy controls: 32 (show all 502)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1GCGglucagonColon-9.140.000
2GUCA2Bguanylate cyclase activator 2B (uroguanylin)Colon-8.780.000
3MS4A12membrane-spanning 4-domains, subfamily A, member 12Colon-8.780.000
4AQP8aquaporin 8Colon-8.300.000
5CA1carbonic anhydrase IColon-8.110.000
6CLCA4chloride channel accessory 4Colon-7.630.000
7CA4carbonic anhydrase IVColon-7.510.000
8TCN1transcobalamin I (vitamin B12 binding protein, R binder family)Colon+7.340.000
9CLDN8claudin 8Colon-7.180.000
10CDH3cadherin 3, type 1, P-cadherin (placental)Colon+6.970.000
11GUCA2Aguanylate cyclase activator 2A (guanylin)Colon-6.920.000
12HLA-DQB1major histocompatibility complex, class II, DQ beta 1Colon-6.850.001
13PRAC1prostate cancer susceptibility candidate 1Colon-6.720.040
14CEMIPcell migration inducing protein, hyaluronan bindingColon+6.690.000
15INSL5insulin-like 5Colon-6.670.000
16PYYpeptide YYColon-6.570.000
17SCNN1Bsodium channel, non-voltage-gated 1, beta subunitColon-6.530.000
18CHGAchromogranin A (parathyroid secretory protein 1)Colon-6.300.000
19CDH3cadherin 3, type 1, P-cadherin (placental)Colon+6.140.000
20SSTsomatostatinColon-5.990.000
21ABCG2ATP-binding cassette, sub-family G (WHITE), member 2Colon-5.770.002
22HCAR3hydroxycarboxylic acid receptor 3Colon+5.600.000
23INHBAinhibin, beta AColon+5.560.000
24SLC51Bsolute carrier family 51, beta subunitColon-5.540.001
25CD177CD177 moleculeColon-5.520.003
26GCNT2glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)Colon-5.480.000
27SLC25A34solute carrier family 25, member 34Colon-5.430.000
28FBLN1fibulin 1Kidney-5.420.000
29SLC26A3solute carrier family 26 (anion exchanger), member 3Colon-5.390.002
30CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Colon-5.350.000
31ZG16zymogen granule protein 16Colon-5.340.000
32MSX2msh homeobox 2Colon+5.310.000
33FABP6fatty acid binding protein 6, ilealColon+5.290.000
34IL8interleukin 8Colon+5.260.000
35EPHX4epoxide hydrolase 4Colon+5.240.000
36DUSP27dual specificity phosphatase 27 (putative)Colon+5.230.000
37TACSTD2tumor-associated calcium signal transducer 2Colon+5.100.000
38GABRPgamma-aminobutyric acid (GABA) A receptor, piColon+5.080.003
39BEST4bestrophin 4Colon-5.080.001
40S100A2S100 calcium binding protein A2Colon+5.050.000
41DPEP1dipeptidase 1 (renal)Colon+5.040.010
42MUC12mucin 12, cell surface associatedColon-4.980.020
43SPINK5serine peptidase inhibitor, Kazal type 5Colon-4.960.001
44PCSK1proprotein convertase subtilisin/kexin type 1Colon+4.920.008
45SLC30A10solute carrier family 30, member 10Colon-4.890.003
46TMEM72transmembrane protein 72Colon-4.880.000
47KLK10kallikrein-related peptidase 10Colon+4.850.020
48COL12A1collagen, type XII, alpha 1Colon+4.840.000
49CDH19cadherin 19, type 2Colon-4.830.001
50CDKN2B-AS1CDKN2B antisense RNA 1Colon-4.750.004
51MT1Mmetallothionein 1MColon-4.750.027
52SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19Colon-4.710.007
53PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Colon-4.700.000
54ANO5anoctamin 5Colon-4.680.000
55CEMIPcell migration inducing protein, hyaluronan bindingColon+4.630.008
56FOXQ1forkhead box Q1Colon+4.620.000
57CEACAM7carcinoembryonic antigen-related cell adhesion molecule 7Colon-4.600.001
58MMP7matrix metallopeptidase 7 (matrilysin, uterine)Colon+4.590.003
59TEX11testis expressed 11Colon-4.560.000
60ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Colon-4.550.000
61KRT6Bkeratin 6BColon+4.550.006
62SLC22A3solute carrier family 22 (organic cation transporter), member 3Colon+4.550.001
63C2CD4AC2 calcium-dependent domain containing 4AColon+4.540.000
64CRNDEcolorectal neoplasia differentially expressed (non-protein coding)Colon+4.530.000
65CA2carbonic anhydrase IIColon-4.530.001
66CCL8chemokine (C-C motif) ligand 8Colon-4.510.000
67NEUROD1neuronal differentiation 1Colon-4.490.001
68ALPIalkaline phosphatase, intestinalColon-4.480.000
69INHBAinhibin, beta AColon+4.470.001
70OGNosteoglycinColon-4.460.000
71KIAA2022KIAA2022Colon-4.440.004
72COL12A1collagen, type XII, alpha 1Colon+4.410.000
73L1TD1LINE-1 type transposase domain containing 1Colon+4.410.004
74SLC15A1solute carrier family 15 (oligopeptide transporter), member 1Colon-4.410.006
75C21orf88chromosome 21 open reading frame 88Colon-4.410.004
76ACHEacetylcholinesterase (Yt blood group)Colon-4.390.000
77NPWneuropeptide WColon+4.390.035
78EPB41L3erythrocyte membrane protein band 4.1-like 3Colon-4.380.009
79SLC35D3solute carrier family 35, member D3Colon+4.370.007
80CRYBA2crystallin, beta A2Colon-4.370.000
81GREM1gremlin 1, DAN family BMP antagonistColon+4.370.002
82VSTM2AV-set and transmembrane domain containing 2AColon-4.360.008
83LOC100289026putative uncharacterized protein FLJ00310-likeColon+4.320.012
84MUC5ACmucin 5AC, oligomeric mucus/gel-formingColon+4.310.019
85RBM24RNA binding motif protein 24Colon-4.310.011
86SH3TC2SH3 domain and tetratricopeptide repeats 2Colon+4.290.000
87WDR72WD repeat domain 72Colon+4.280.005
88SLC4A4solute carrier family 4 (sodium bicarbonate cotransporter), member 4Colon-4.260.002
89GLDNgliomedinColon-4.220.006
90DPP4dipeptidyl-peptidase 4Colon-4.210.002
91SLC16A4solute carrier family 16, member 4Colon+4.160.001
92CA7carbonic anhydrase VIIColon-4.160.001
93XKR4XK, Kell blood group complex subunit-related family, member 4Colon-4.160.000
94EDN3endothelin 3Colon-4.150.000
95LGALS2lectin, galactoside-binding, soluble, 2Colon-4.140.001
96DHRS9dehydrogenase/reductase (SDR family) member 9Colon-4.130.004
97PKIBprotein kinase (cAMP-dependent, catalytic) inhibitor betaColon-4.110.001
98ENPP6ectonucleotide pyrophosphatase/phosphodiesterase 6Colon-4.110.005
99DSG3desmoglein 3Colon+4.110.003
100FAM3Bfamily with sequence similarity 3, member BColon+4.100.023
101IL20RAinterleukin 20 receptor, alphaColon+4.090.009
102DPP10dipeptidyl-peptidase 10 (non-functional)Colon-4.080.000
103UGT2A3UDP glucuronosyltransferase 2 family, polypeptide A3Colon-4.080.003
104STC2stanniocalcin 2Colon+4.070.006
105DPEP2dipeptidase 2Colon-4.060.000
106PLP1proteolipid protein 1Colon-4.050.009
107ANPEPalanyl (membrane) aminopeptidaseColon-4.050.003
108LOC254057uncharacterized LOC254057Colon+4.050.001
109ETV4ets variant 4Colon+4.040.000
110CXCL12chemokine (C-X-C motif) ligand 12Colon-4.030.022
111RETNLBresistin like betaColon+4.030.039
112SUGCTsuccinylCoA:glutarate-CoA transferaseColon-4.030.006
113SIsucrase-isomaltase (alpha-glucosidase)Colon-4.010.028
114NRXN1neurexin 1Colon-4.010.013
115SP5Sp5 transcription factorColon+3.990.001
116WSCD1WSC domain containing 1Colon-3.980.030
117CXCL5chemokine (C-X-C motif) ligand 5Colon+3.970.004
118SCG2secretogranin IIColon-3.970.012
119KRT23keratin 23 (histone deacetylase inducible)Colon+3.960.017
120CR2complement component (3d/Epstein Barr virus) receptor 2Colon-3.950.003
121FABP4fatty acid binding protein 4, adipocyteColon-3.950.008
122UBE2QL1ubiquitin-conjugating enzyme E2Q family-like 1Colon-3.930.000
123SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5Colon+3.930.003
124AMPD1adenosine monophosphate deaminase 1Colon-3.930.023
125FGFBP2fibroblast growth factor binding protein 2Colon-3.930.000
126SCGNsecretagogin, EF-hand calcium binding proteinColon-3.930.001
127EYA2eyes absent homolog 2 (Drosophila)Colon-3.920.029
128SLC26A2solute carrier family 26 (anion exchanger), member 2Colon-3.880.000
129DPEP1dipeptidase 1 (renal)Colon+3.880.039
130TMCO5Btransmembrane and coiled-coil domains 5B, pseudogeneColon-3.880.000
131PNLIPRP2pancreatic lipase-related protein 2Colon-3.880.042
132MYOTmyotilinColon-3.880.011
133CNKSR2connector enhancer of kinase suppressor of Ras 2Colon-3.870.021
134MALLmal, T-cell differentiation protein-likeColon-3.870.000
135MFAP4microfibrillar-associated protein 4Colon-3.860.004
136COL11A1collagen, type XI, alpha 1Colon+3.860.007
137CDC14Ccell division cycle 14CColon-3.850.008
138TDRD5tudor domain containing 5Colon+3.840.004
139BRINP3bone morphogenetic protein/retinoic acid inducible neural-specific 3Colon-3.840.012
140ANGPTL1angiopoietin-like 1Colon-3.840.037
141TAC1tachykinin, precursor 1Colon+3.830.031
142IL33interleukin 33Colon+3.810.003
143KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5Colon-3.810.002
144S100A2S100 calcium binding protein A2Colon+3.800.013
145KRT80keratin 80Colon+3.800.001
146LGI4leucine-rich repeat LGI family, member 4Colon-3.790.000
147MST1Lmacrophage stimulating 1-likeColon-3.790.021
148ITPKAinositol-trisphosphate 3-kinase AColon-3.790.011
149LPLlipoprotein lipaseColon+3.780.003
150CLDN2claudin 2Colon+3.770.002
151GRIA3glutamate receptor, ionotropic, AMPA 3Colon-3.760.025
152MFSD4major facilitator superfamily domain containing 4Colon-3.750.039
153CYP4X1cytochrome P450, family 4, subfamily X, polypeptide 1Colon+3.750.001
154CPMcarboxypeptidase MColon-3.750.011
155KRT6Bkeratin 6BColon+3.730.002
156KRT23keratin 23 (histone deacetylase inducible)Colon+3.730.004
157SBSPONsomatomedin B and thrombospondin, type 1 domain containingColon+3.720.002
158GPM6Bglycoprotein M6BColon-3.720.000
159SCNN1Gsodium channel, non-voltage-gated 1, gamma subunitColon-3.720.019
160UNC5Cunc-5 homolog C (C. elegans)Colon-3.710.016
161SCN7Asodium channel, voltage-gated, type VII, alpha subunitColon-3.700.001
162ZNF229zinc finger protein 229Colon-3.670.001
163GIFgastric intrinsic factor (vitamin B synthesis)Colon+3.670.002
164LRRN1leucine rich repeat neuronal 1Colon+3.670.015
165FMN2formin 2Colon-3.670.016
166OSR1odd-skipped related transciption factor 1Colon-3.660.000
167GALNT6polypeptide N-acetylgalactosaminyltransferase 6Colon+3.660.004
168LAMA4laminin, alpha 4Colon-3.660.007
169ASCL2achaete-scute family bHLH transcription factor 2Colon+3.650.009
170SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6Colon-3.650.009
171OLFM1olfactomedin 1Colon-3.640.001
172ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideColon-3.640.039
173NR5A2nuclear receptor subfamily 5, group A, member 2Colon-3.640.049
174SLC28A3solute carrier family 28 (concentrative nucleoside transporter), member 3Colon+3.630.001
175NAALADL1N-acetylated alpha-linked acidic dipeptidase-like 1Colon-3.630.000
176SV2Bsynaptic vesicle glycoprotein 2BColon-3.630.000
177MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Colon+3.630.044
178FXYD1FXYD domain containing ion transport regulator 1Colon-3.630.003
179TNS4tensin 4Colon+3.620.002
180CDH12cadherin 12, type 2 (N-cadherin 2)Colon-3.620.003
181HRCT1histidine rich carboxyl terminus 1Colon-3.620.000
182HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Colon-3.620.038
183DOCK10dedicator of cytokinesis 10Colon-3.600.026
184ADAMDEC1ADAM-like, decysin 1Colon-3.600.000
185SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinColon-3.600.004
186HSD17B2hydroxysteroid (17-beta) dehydrogenase 2Colon-3.600.006
187KLHL32kelch-like family member 32Colon+3.590.007
188CLDN23claudin 23Colon-3.590.000
189PIK3R5phosphoinositide-3-kinase, regulatory subunit 5Colon-3.590.001
190SPIBSpi-B transcription factor (Spi-1/PU.1 related)Colon-3.570.004
191RNF165ring finger protein 165Colon-3.560.001
192DLX6-AS1DLX6 antisense RNA 1Colon+3.550.015
193SIM2single-minded family bHLH transcription factor 2Colon+3.540.004
194CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Colon-3.540.031
195C11orf86chromosome 11 open reading frame 86Colon-3.520.000
196LRRC8Eleucine rich repeat containing 8 family, member EColon+3.520.001
197USP2ubiquitin specific peptidase 2Colon-3.520.005
198TRPM6transient receptor potential cation channel, subfamily M, member 6Colon-3.520.001
199GLS2glutaminase 2 (liver, mitochondrial)Colon+3.500.000
200DUSP4dual specificity phosphatase 4Colon+3.500.015
201LGR5leucine-rich repeat containing G protein-coupled receptor 5Colon+3.500.012
202TTLL6tubulin tyrosine ligase-like family, member 6Colon-3.490.021
203ZNF605zinc finger protein 605Colon-3.490.007
204SLCO2B1solute carrier organic anion transporter family, member 2B1Colon-3.480.005
205CXCL13chemokine (C-X-C motif) ligand 13Colon-3.470.037
206SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DColon-3.470.025
207FLJ36848uncharacterized LOC647115Colon-3.470.005
208EPHA3EPH receptor A3Colon-3.460.017
209ATF7IPactivating transcription factor 7 interacting proteinColon+3.460.025
210CDHR5cadherin-related family member 5Colon-3.460.000
211MMP10matrix metallopeptidase 10 (stromelysin 2)Colon+3.460.023
212KIAA1549KIAA1549Colon+3.450.003
213ZDHHC2zinc finger, DHHC-type containing 2Colon+3.450.000
214AXIN2axin 2Colon+3.440.001
215SPINK4serine peptidase inhibitor, Kazal type 4Colon+3.440.000
216INSM1insulinoma-associated 1Colon-3.440.018
217DNAH14dynein, axonemal, heavy chain 14Colon+3.440.000
218SPON1spondin 1, extracellular matrix proteinColon-3.440.000
219HPGDhydroxyprostaglandin dehydrogenase 15-(NAD)Colon-3.430.000
220TRDT cell receptor delta locusColon-3.430.001
221C11orf65chromosome 11 open reading frame 65Colon+3.430.000
222GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DColon+3.430.001
223ASB2ankyrin repeat and SOCS box containing 2Colon-3.430.007
224STMN2stathmin 2Colon-3.420.009
225KLK11kallikrein-related peptidase 11Colon+3.420.001
226NAP1L2nucleosome assembly protein 1-like 2Colon-3.420.004
227TCF21transcription factor 21Colon-3.420.001
228IGHA1immunoglobulin heavy constant alpha 1Colon-3.420.003
229LCN2lipocalin 2Colon+3.420.003
230POSTNperiostin, osteoblast specific factorColon-3.420.000
231FCRL2Fc receptor-like 2Colon-3.410.000
232KRT78keratin 78Colon-3.410.002
233HERC6HECT and RLD domain containing E3 ubiquitin protein ligase family member 6Colon-3.410.019
234CYTL1cytokine-like 1Colon-3.410.011
235CHP2calcineurin-like EF-hand protein 2Colon-3.410.004
236LOC401463uncharacterized LOC401463Colon-3.410.013
237IGLV1-36immunoglobulin lambda variable 1-36Colon-3.400.020
238SIGLEC6sialic acid binding Ig-like lectin 6Colon-3.390.002
239CHRM3cholinergic receptor, muscarinic 3Colon+3.390.031
240TSPAN5tetraspanin 5Colon+3.390.004
241REG4regenerating islet-derived family, member 4Colon+3.380.001
242VSTM4V-set and transmembrane domain containing 4Colon-3.380.011
243C2orf88chromosome 2 open reading frame 88Colon-3.380.000
244GGT5gamma-glutamyltransferase 5Colon-3.380.006
245PIANPPILR alpha associated neural proteinColon-3.370.001
246COL11A1collagen, type XI, alpha 1Colon+3.360.001
247HOXC6homeobox C6Colon+3.360.017
248PDE3Aphosphodiesterase 3A, cGMP-inhibitedColon-3.360.001
249FAM150Bfamily with sequence similarity 150, member BColon-3.360.008
250SOSTDC1sclerostin domain containing 1Colon-3.350.000
251PLAC9placenta-specific 9Colon-3.350.006
252CDRT1CMT1A duplicated region transcript 1Colon-3.350.002
253GPR55G protein-coupled receptor 55Colon-3.350.004
254SORCS1sortilin-related VPS10 domain containing receptor 1Colon-3.340.024
255MSX1msh homeobox 1Colon+3.340.002
256CPNE8copine VIIIColon-3.340.009
257MFAP5microfibrillar associated protein 5Colon-3.340.024
258BAI3brain-specific angiogenesis inhibitor 3Colon-3.330.030
259CHADchondroadherinColon-3.330.002
260TAF13TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDaColon-3.320.004
261PPP1R10protein phosphatase 1, regulatory subunit 10Blood+3.310.000
262XKRXXK, Kell blood group complex subunit-related, X-linkedColon+3.300.000
263CRNDEcolorectal neoplasia differentially expressed (non-protein coding)Colon+3.300.013
264CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Colon+3.290.003
265CHDHcholine dehydrogenaseColon+3.280.012
266MUC5ACmucin 5AC, oligomeric mucus/gel-formingColon+3.280.044
267TMEFF2transmembrane protein with EGF-like and two follistatin-like domains 2Colon+3.270.009
268FAIM2Fas apoptotic inhibitory molecule 2Colon+3.270.003
269DUSP18dual specificity phosphatase 18Colon+3.270.001
270CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1Colon+3.260.031
271MTRF1mitochondrial translational release factor 1Colon+3.250.006
272TBX3T-box 3Colon+3.230.004
273CCDC3coiled-coil domain containing 3Colon+3.220.022
274CADPSCa++-dependent secretion activatorColon+3.140.003
275TUBB1tubulin, beta 1 class VIColon+3.140.002
276MCM10minichromosome maintenance complex component 10Colon+3.140.001
277KRT80keratin 80Colon+3.130.016
278CHDHcholine dehydrogenaseColon+3.130.049
279RECQL5RecQ protein-like 5Colon+3.110.007
280ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2Colon+3.110.007
281DUOX2dual oxidase 2Colon+3.100.018
282IL17Finterleukin 17FColon+3.100.000
283MMP7matrix metallopeptidase 7 (matrilysin, uterine)Colon+3.090.041
284GLYATL1glycine-N-acyltransferase-like 1Colon+3.080.007
285TLR4toll-like receptor 4Colon+3.080.001
286CFIcomplement factor IColon+3.070.027
287SRPX2sushi-repeat containing protein, X-linked 2Colon+3.050.002
288NLRP11NLR family, pyrin domain containing 11Colon+3.030.001
289MSLNmesothelinColon+3.030.025
290ZNF446zinc finger protein 446Colon+3.010.001
291SPATA6Lspermatogenesis associated 6-likeColon+3.010.001
292RASAL2RAS protein activator like 2Colon+3.000.023
293RP11-333E1.1uncharacterized LOC100130950Colon+2.990.022
294EVA1Aeva-1 homolog A (C. elegans)Colon+2.980.015
295LRRC8Eleucine rich repeat containing 8 family, member EColon+2.980.001
296PTP4A3protein tyrosine phosphatase type IVA, member 3Colon+2.970.014
297FUT7fucosyltransferase 7 (alpha (1,3) fucosyltransferase)Blood+2.960.001
298SP5Sp5 transcription factorColon+2.950.046
299THBDthrombomodulinColon+2.930.003
300ANKS6ankyrin repeat and sterile alpha motif domain containing 6Colon+2.920.000
301PTP4A3protein tyrosine phosphatase type IVA, member 3Colon+2.920.005
302KRT17keratin 17Colon+2.910.032
303FAPfibroblast activation protein, alphaColon+2.910.030
304HDAC9histone deacetylase 9Colon+2.910.007
305MUC6mucin 6, oligomeric mucus/gel-formingColon+2.910.000
306PROK2prokineticin 2Colon+2.900.032
307DYX1C1dyslexia susceptibility 1 candidate 1Colon+2.900.001
308GABRPgamma-aminobutyric acid (GABA) A receptor, piColon+2.900.045
309PABPC1Lpoly(A) binding protein, cytoplasmic 1-likeColon+2.890.022
310RPL32P3ribosomal protein L32 pseudogene 3Colon+2.890.010
311C19orf45chromosome 19 open reading frame 45Colon+2.890.000
312DBNDD1dysbindin (dystrobrevin binding protein 1) domain containing 1Colon+2.880.000
313FADS1fatty acid desaturase 1Colon+2.880.006
314SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1Colon+2.880.022
315MMP1matrix metallopeptidase 1 (interstitial collagenase)Colon+2.870.034
316PSPHphosphoserine phosphataseColon+2.840.028
317SLFN5schlafen family member 5Colon+2.840.025
318TPCN2two pore segment channel 2Colon+2.840.000
319COG2component of oligomeric golgi complex 2Colon+2.840.022
320TGFB2transforming growth factor, beta 2Colon+2.830.015
321PLEKHA8pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8Colon+2.830.011
322MEGF6multiple EGF-like-domains 6Colon+2.830.012
323CXCL3chemokine (C-X-C motif) ligand 3Colon+2.810.048
324TNFSF15tumor necrosis factor (ligand) superfamily, member 15Colon+2.800.007
325CMIPc-Maf inducing proteinColon+2.790.004
326CD44CD44 molecule (Indian blood group)Colon+2.790.005
327STK31serine/threonine kinase 31Colon+2.790.003
328HBEGFheparin-binding EGF-like growth factorColon+2.790.032
329KDELR3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3Colon+2.780.006
330UBE2Oubiquitin-conjugating enzyme E2OColon+2.770.001
331CLCN4chloride channel, voltage-sensitive 4Colon+2.760.004
332S100A8S100 calcium binding protein A8Colon+2.760.048
333ARHGEF28Rho guanine nucleotide exchange factor (GEF) 28Colon+2.760.021
334ASB4ankyrin repeat and SOCS box containing 4Colon+2.750.001
335STRIP2striatin interacting protein 2Colon+2.750.009
336SLC25A27solute carrier family 25, member 27Colon+2.750.004
337SUGP2SURP and G patch domain containing 2Colon+2.750.003
338SH3TC2SH3 domain and tetratricopeptide repeats 2Colon+2.750.003
339LCN2lipocalin 2Colon+2.740.042
340CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Colon+2.740.037
341DNAH10dynein, axonemal, heavy chain 10Colon+2.740.002
342ZNF446zinc finger protein 446Colon+2.740.006
343PDPNpodoplaninColon+2.740.020
344AQP9aquaporin 9Colon+2.730.041
345CXCL3chemokine (C-X-C motif) ligand 3Colon+2.730.028
346SLITRK6SLIT and NTRK-like family, member 6Colon+2.730.005
347CEP72centrosomal protein 72kDaColon+2.720.048
348PRUNE2prune homolog 2 (Drosophila)Colon+2.720.007
349FNDC3Bfibronectin type III domain containing 3BColon+2.720.015
350KCNN2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2Colon+2.720.020
351SPATA45spermatogenesis associated 45Colon+2.720.005
352IGFBP5insulin-like growth factor binding protein 5Colon+2.710.003
353DBNDD1dysbindin (dystrobrevin binding protein 1) domain containing 1Colon+2.710.004
354LOC728061hCG2003663Colon+2.700.029
355IQCHIQ motif containing HColon+2.700.004
356TRIM29tripartite motif containing 29Colon+2.700.038
357PLCB1phospholipase C, beta 1 (phosphoinositide-specific)Colon+2.690.002
358GALgalanin/GMAP prepropeptideColon+2.680.037
359ARHGEF10Rho guanine nucleotide exchange factor (GEF) 10Colon+2.680.013
360LAMP1lysosomal-associated membrane protein 1Blood+2.680.004
361CCDC148coiled-coil domain containing 148Colon+2.680.030
362IL20RAinterleukin 20 receptor, alphaColon+2.680.043
363CEP41centrosomal protein 41kDaColon+2.680.009
364KRI1KRI1 homolog (S. cerevisiae)Colon+2.670.000
365DGAT2diacylglycerol O-acyltransferase 2Colon+2.670.007
366FGF18fibroblast growth factor 18Colon+2.670.034
367PABPC1Lpoly(A) binding protein, cytoplasmic 1-likeColon+2.660.015
368TMEM51-AS1TMEM51 antisense RNA 1Colon+2.660.041
369KLHL22kelch-like family member 22Blood+2.660.002
370SNRKSNF related kinaseColon+2.660.002
371TGFBItransforming growth factor, beta-induced, 68kDaColon+2.650.000
372DNM3dynamin 3Colon+2.650.004
373BICD1bicaudal D homolog 1 (Drosophila)Colon+2.650.041
374DYX1C1dyslexia susceptibility 1 candidate 1Colon+2.650.006
375SNRKSNF related kinaseColon+2.640.016
376APLNapelinColon+2.630.002
377INADLInaD-like (Drosophila)Colon+2.630.036
378SPP1secreted phosphoprotein 1Colon+2.630.020
379LOC286071uncharacterized LOC286071Colon+2.620.039
380ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2Colon+2.600.016
381STARD13StAR-related lipid transfer (START) domain containing 13Colon+2.600.014
382KRT7keratin 7Colon+2.600.001
383WDR4WD repeat domain 4Colon+2.600.038
384TMEM87Atransmembrane protein 87AColon+2.590.027
385LRRC6leucine rich repeat containing 6Colon+2.590.001
386LRRC2leucine rich repeat containing 2Colon+2.590.013
387PHLDA1pleckstrin homology-like domain, family A, member 1Colon+2.580.005
388PLNphospholambanColon+2.580.044
389C4BPBcomplement component 4 binding protein, betaColon+2.580.019
390OSR2odd-skipped related transciption factor 2Colon+2.580.042
391FKBP10FK506 binding protein 10, 65 kDaColon+2.580.019
392RRP12ribosomal RNA processing 12 homolog (S. cerevisiae)Colon+2.580.024
393DNM1dynamin 1Colon+2.580.003
394ZDHHC1zinc finger, DHHC-type containing 1Colon+2.570.027
395SETD5SET domain containing 5Colon+2.570.037
396CLCN4chloride channel, voltage-sensitive 4Colon+2.570.014
397METmet proto-oncogeneColon+2.570.007
398CLDN1claudin 1Colon+2.570.003
399ANKUB1ankyrin repeat and ubiquitin domain containing 1Colon+2.570.047
400CCDC38coiled-coil domain containing 38Colon+2.570.013
401PSMB7proteasome (prosome, macropain) subunit, beta type, 7Colon+2.560.026
402MAATS1MYCBP-associated, testis expressed 1Colon+2.560.035
403LINC01133long intergenic non-protein coding RNA 1133Colon+2.560.009
404RP3-510O8.4uncharacterized LOC285847Colon+2.560.022
405MIATmyocardial infarction associated transcript (non-protein coding)Blood+2.560.006
406AZGP1alpha-2-glycoprotein 1, zinc-bindingColon+2.560.001
407APLFaprataxin and PNKP like factorColon+2.550.014
408DPYSL3dihydropyrimidinase-like 3Colon+2.550.009
409SULT1C2sulfotransferase family, cytosolic, 1C, member 2Colon+2.540.016
410PVT1Pvt1 oncogene (non-protein coding)Colon+2.540.001
411DKFZp451B082uncharacterized LOC401282Colon+2.540.007
412GPR132G protein-coupled receptor 132Blood+2.530.002
413ANXA9annexin A9Colon+2.530.006
414ADAM12ADAM metallopeptidase domain 12Colon+2.530.021
415RASAL2RAS protein activator like 2Colon+2.520.031
416LINC00883long intergenic non-protein coding RNA 883Colon+2.520.017
417FJX1four jointed box 1 (Drosophila)Colon+2.520.016
418MCM9minichromosome maintenance complex component 9Colon+2.520.036
419KIF12kinesin family member 12Colon+2.520.024
420ACRBPacrosin binding proteinColon+2.520.043
421ZDHHC11zinc finger, DHHC-type containing 11Colon+2.510.014
422TRIM29tripartite motif containing 29Colon+2.510.001
423HOOK3hook microtubule-tethering protein 3Colon+2.510.041
424NFIXnuclear factor I/X (CCAAT-binding transcription factor)Colon+2.510.011
425MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)Blood+2.510.011
426ATP11CATPase, class VI, type 11CColon+2.510.022
427DLX6distal-less homeobox 6Colon+2.500.005
428OSR2odd-skipped related transciption factor 2Colon+2.500.028
429PLEKHA8pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8Colon+2.500.014
430RAB18RAB18, member RAS oncogene familyColon+2.490.006
431IL17Finterleukin 17FColon+2.490.006
432SULT2B1sulfotransferase family, cytosolic, 2B, member 1Colon+2.490.003
433LOC100131170uncharacterized LOC100131170Blood+2.480.003
434PLA1Aphospholipase A1 member AColon+2.480.018
435ARL9ADP-ribosylation factor-like 9Colon+2.480.025
436CDK6cyclin-dependent kinase 6Colon+2.470.028
437CCDC150coiled-coil domain containing 150Colon+2.470.012
438GUSBP1glucuronidase, beta pseudogene 1Colon+2.470.023
439MROH1maestro heat-like repeat family member 1Colon+2.470.003
440COL28A1collagen, type XXVIII, alpha 1Colon+2.470.012
441USP24ubiquitin specific peptidase 24Colon+2.470.003
442DHX30DEAH (Asp-Glu-Ala-His) box helicase 30Colon+2.470.048
443LOC645513uncharacterized LOC645513Colon+2.470.020
444PGBD1piggyBac transposable element derived 1Colon+2.460.032
445HBEGFheparin-binding EGF-like growth factorColon+2.460.024
446PLSCR3phospholipid scramblase 3Colon+2.460.002
447PLEKHG2pleckstrin homology domain containing, family G (with RhoGef domain) member 2Colon+2.460.039
448ARVCFarmadillo repeat gene deleted in velocardiofacial syndromeColon+2.460.015
449KDELR3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3Colon+2.460.034
450SOX4SRY (sex determining region Y)-box 4Colon+2.450.038
451NPC1Niemann-Pick disease, type C1Colon+2.450.034
452MCOLN1mucolipin 1Blood+2.450.010
453WWC1WW and C2 domain containing 1Colon+2.450.024
454ZDHHC2zinc finger, DHHC-type containing 2Colon+2.450.030
455SLC6A6solute carrier family 6 (neurotransmitter transporter), member 6Colon+2.450.001
456RHBDF1rhomboid 5 homolog 1 (Drosophila)Colon+2.450.001
457GJA5gap junction protein, alpha 5, 40kDaColon+2.440.009
458COG2component of oligomeric golgi complex 2Colon+2.420.015
459SLC16A4solute carrier family 16, member 4Colon+2.420.016
460AKAP10A kinase (PRKA) anchor protein 10Colon+2.420.007
461ADAM22ADAM metallopeptidase domain 22Colon+2.410.032
462SORCS2sortilin-related VPS10 domain containing receptor 2Colon+2.400.004
463ANKS6ankyrin repeat and sterile alpha motif domain containing 6Colon+2.400.033
464STAT5Bsignal transducer and activator of transcription 5BColon+2.400.027
465GAS1growth arrest-specific 1Colon+2.380.048
466EMC8ER membrane protein complex subunit 8Blood+2.380.004
467HELLShelicase, lymphoid-specificBlood+2.380.006
468FKBP10FK506 binding protein 10, 65 kDaColon+2.380.022
469GALNT6polypeptide N-acetylgalactosaminyltransferase 6Colon+2.380.024
470C9orf62chromosome 9 open reading frame 62Colon+2.370.009
471RAB12RAB12, member RAS oncogene familyColon+2.350.025
472GDF11growth differentiation factor 11Colon+2.350.020
473CMIPc-Maf inducing proteinColon+2.350.029
474ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9Colon+2.340.010
475MROH1maestro heat-like repeat family member 1Colon+2.340.002
476ETNK1ethanolamine kinase 1Colon+2.330.034
477SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5Colon+2.330.025
478ADCK5aarF domain containing kinase 5Colon+2.320.013
479FOXP3forkhead box P3Colon+2.320.022
480TAGAPT-cell activation RhoGTPase activating proteinColon+2.310.038
481TRMT2BtRNA methyltransferase 2 homolog B (S. cerevisiae)Colon+2.310.001
482CLPBClpB caseinolytic peptidase B homolog (E. coli)Colon+2.300.029
483GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeColon+2.300.005
484TMEFF2transmembrane protein with EGF-like and two follistatin-like domains 2Colon+2.300.014
485TIMP1TIMP metallopeptidase inhibitor 1Colon+2.290.001
486COL1A2collagen, type I, alpha 2Colon+2.290.003
487HSPA12Bheat shock 70kD protein 12BColon+2.280.035
488ABHD11abhydrolase domain containing 11Blood+2.280.014
489STC1stanniocalcin 1Colon+2.280.027
490FSCN1fascin actin-bundling protein 1Colon+2.270.018
491SPTBN2spectrin, beta, non-erythrocytic 2Colon+2.260.006
492FAM20Afamily with sequence similarity 20, member ABlood+2.250.033
493SLC38A1solute carrier family 38, member 1Skeletal Muscle+2.110.017
494SLC22A3solute carrier family 22 (organic cation transporter), member 3Skeletal Muscle+1.970.002
495RPL38ribosomal protein L38Skeletal Muscle-1.870.025
496PDE4Dphosphodiesterase 4D, cAMP-specificSkeletal Muscle+1.850.013
497NREPneuronal regeneration related proteinSkeletal Muscle-1.850.005
498VDAC3voltage-dependent anion channel 3Skeletal Muscle-1.760.002
499YBX3Y box binding protein 3Skeletal Muscle-1.660.044
500LINC00310long intergenic non-protein coding RNA 310Skeletal Muscle-1.650.015
501HDAC9histone deacetylase 9Skeletal Muscle-1.540.010
502SCN3Bsodium channel, voltage-gated, type III, beta subunitSkeletal Muscle+1.380.039


Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

About this section

Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.7TP53, APC, PIK3CA, AKT1, DCC, BRAF
2
Show member pathways
Signal transduction PTEN pathway60
11.5PIK3CA, BAX, APC, TP53, DCC, BRAF
311.4BUB1B, APC, TP53, EP300, AKT1, CCND1
4
Show member pathways
11.4CCND1, NRAS, CTNNB1, AKT1, FGFR3, PIK3CA
5
Show member pathways
11.4TP53, CCND1, NRAS, BAX, CTNNB1, AKT1
611.4CTNNB1, BAX, NRAS, CCND1, AKT1, PIK3CA
7
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
11.4CTNNB1, BAX, BUB1B, TP53, ODC1, APC
811.3APC, CCND1, BAX, CTNNB1, AXIN2, AKT1
9
Show member pathways
Signaling Pathways in Glioblastoma38
11.3CTNNB1, EP300, TP53, PIK3CA, FGFR3, AKT1
10
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
11.2AXIN2, CCND1, AKT1, EP300, APC, TP53
1111.2TP53, AURKA, EP300, AKT1, CCND1, BAX
12
Show member pathways
11.2FGFR3, BAX, NRAS, CCND1, AKT1, EP300
13
Show member pathways
Wnt Signaling Pathway NetPath38
11.1AXIN2, AKT1, CTNNB1, CCND1, EP300, TP53
1411.1NRAS, BRAF, APC, TP53, CTNNB1, CCND1
1511.1AKT1, NRAS, CTNNB1, TP53, PIK3CA, CCND1
1611.1TP53, EP300, CCND1, PIK3CA, NRAS, FGFR3
1711.1NRAS, CTNNB1, AKT1, TP53, EP300, PIK3CA
18
Show member pathways
11.1TP53, EP300, BRAF, AKT1, CCND1, NRAS
19
Show member pathways
11.1CTNNB1, BAX, NRAS, TP53, PIK3CA, FGFR3
20
Show member pathways
11.1NRAS, AKT1, BAX, EP300, BRAF, TP53
21
Show member pathways
11.1EP300, NRAS, TP53, AKT1, BRAF, BAX
22
Show member pathways
11.1NRAS, BRAF, FGFR3, BAX, AKT1, EP300
23
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
11.1NRAS, PIK3CA, CCND1, AKT1, EP300, BAX
24
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
11.0PIK3CA, BRAF, AKT1, NRAS, CTNNB1, CCND1
25
Show member pathways
11.0BRAF, AKT1, NRAS, CTNNB1, FGFR3, PIK3CA
26
Show member pathways
11.0AXIN2, CTNNB1, APC, TP53, EP300, NRAS
27
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
11.0NRAS, CCND1, AKT1, BRAF, TP53, PIK3CA
28
Show member pathways
11.0AKT1, BRAF, PIK3CA, CCND1, NRAS, TP53
29
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
11.0AKT1, BRAF, CCND1, NRAS, EP300, PIK3CA
3011.0NRAS, CCND1, AKT1, TP53, PIK3CA, FGFR3
31
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
11.0TP53, BRAF, AKT1, BAX, NRAS, PIK3CA
32
Show member pathways
11.0BAX, FGFR3, NRAS, AKT1, BRAF, PIK3CA
3311.0EP300, NRAS, AKT1, FLCN, BRAF, PIK3CA
3411.0PIK3CA, EP300, TP53, CCND1, NRAS, BAX
35
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
11.0CCND1, EP300, PIK3CA, AKT1, BAX, NRAS
3611.0AXIN2, CTNNB1, APC, CCND1, EP300
3711.0TP53, EP300, CCND1, CTNNB1, AXIN2
3811.0CCND1, TP53, NRAS, CTNNB1, BRAF
39
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
11.0EP300, PIK3CA, AKT1, CCND1, CTNNB1
40
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
11.0PIK3CA, BRAF, AKT1, CTNNB1, NRAS
41
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
11.0BAX, PIK3CA, BRAF, AKT1, CCND1
4211.0CTNNB1, PTPRJ, APC, PIK3CA, AKT1
43
Show member pathways
11.0TP53, PIK3CA, BRAF, AKT1, NRAS
4411.0TP53, BRAF, AKT1, NRAS, PIK3CA
45
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
11.0AKT1, PIK3CA, CCND1, TP53, BAX
46
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
11.0BAX, CCND1, AKT1, TP53, PIK3CA
47
Show member pathways
11.0TP53, EP300, AKT1, CCND1, BAX
48
Show member pathways
11.0TP53, BAX, NRAS, AKT1, BRAF
4910.9CCND1, AKT1, CTNNB1, PIK3CA
50
Show member pathways
10.9BRAF, FGFR3, PIK3CA, NRAS

Compounds for genes affiliated with Colorectal Cancer

About this section

Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1serine4512.2AKT1, ODC1, CTNNB1, CCND1, FGFR3, AURKA
2tyrosine4512.0AKT1, FGFR3, BRAF, ODC1, PTPRJ, PIK3CA
3threonine4512.0FGFR3, AXIN2, CTNNB1, CCND1, AKT1, EP300
4estrogen4512.0PIK3CA, CCND1, AURKA, ODC1, TP53, BAX
5paclitaxel45 51 1313.9ODC1, BRAF, BUB1B, AURKA, PIK3CA, TP53
6doxorubicin45 51 1313.9CTNNB1, FGFR3, AKT1, CCND1, BAX, EP300
7retinoic acid45 2612.8CCND1, CTNNB1, BAX, AKT1, EP300, BRAF
8paraffin4511.8AKT1, FGFR3, CTNNB1, BAX, CCND1, BRAF
9vegf4511.7FGFR3, CTNNB1, AKT1, CCND1, EP300, BRAF
10curcumin4511.7TP53, APC, ODC1, CTNNB1, CCND1, AKT1
11sb 20358045 6112.7CCND1, EP300, TP53, CTNNB1, BAX, AKT1
12rapamycin4511.7PIK3CA, CTNNB1, CCND1, AKT1, FLCN, BRAF
13ly2940024511.7EP300, CTNNB1, BAX, CCND1, AKT1, BRAF
14wortmannin4511.7EP300, CTNNB1, BAX, CCND1, PIK3CA, APC
15cisplatin45 51 61 1314.6BRAF, CTNNB1, BAX, CCND1, AKT1, EP300
16resveratrol45 61 26 1314.6PIK3CA, CTNNB1, ODC1, BAX, CCND1, EP300
17adriamycin4511.6BAX, CCND1, EP300, TP53, ODC1, CTNNB1
18agar4511.5CTNNB1, CCND1, AKT1, ODC1, PIK3CA, BRAF
19arginine4511.5FGFR3, ODC1, TP53, BRAF, EP300, AKT1
20phosphatidylinositol4511.5PIK3CA, EP300, APC, CTNNB1, BRAF, BAX
21butyrate4511.5CCND1, EP300, TP53, BAX, CTNNB1, AKT1
22tamoxifen45 51 30 1314.5TP53, CTNNB1, BAX, AKT1, PIK3CA, CCND1
23pd 98,0594511.5BRAF, EP300, AKT1, BAX, CTNNB1, CCND1
24crcs4511.5PIK3CA, APC, TP53, BRAF, CTNNB1, CCND1
25indole-3-carbinol4511.5CTNNB1, TP53, BAX, CCND1, ODC1, AKT1
26sulindac45 1312.5CCND1, BAX, CTNNB1, APC, ODC1, TP53
27egcg4511.4TP53, CCND1, BAX, CTNNB1, PIK3CA, ODC1
28arsenite45 2612.4PIK3CA, TP53, AKT1, CTNNB1, CCND1, BAX
29guanine45 26 1313.4APC, TP53, FGFR3, AKT1, CTNNB1, CCND1
30retinoid4511.4EP300, TP53, ODC1, BAX, CTNNB1, CCND1
31cycloheximide4511.4BAX, CTNNB1, CCND1, AKT1, APC, TP53
32depsipeptide4511.3BAX, CCND1, EP300, BRAF, TP53
33matrigel4511.3ODC1, PIK3CA, BRAF, AKT1, CCND1, CTNNB1
34progesterone45 30 61 26 1315.3CTNNB1, EP300, PIK3CA, CCND1, BRAF, TP53
35n acetylcysteine4511.3CTNNB1, BAX, CCND1, AKT1, TP53, ODC1
36celecoxib45 61 30 51 26 1316.3CTNNB1, BAX, CCND1, AKT1, APC
37adpribose4511.3PIK3CA, TP53, CCND1, CTNNB1, BAX
38azoxymethane4511.3CCND1, APC, ODC1, CTNNB1
39nocodazole45 1312.2APC, AKT1, CTNNB1, BUB1B, TP53
40exisulind4511.2CCND1, CTNNB1, BAX, APC
41vincristine45 51 1313.2ODC1, TP53, AKT1, CCND1, BAX
42testosterone45 61 26 1314.1CCND1, CTNNB1, EP300, APC, ODC1, PIK3CA
43bromodeoxyuridine4511.1CCND1, ODC1, EP300, PIK3CA, CTNNB1
44samp4511.1AXIN2, APC, CTNNB1
45mg 13245 6112.1CCND1, CTNNB1, AKT1, BAX, TP53
46quercetin45 61 26 1314.0CCND1, BAX, AKT1, PIK3CA, CTNNB1
471,2-dimethylhydrazine4511.0APC, CTNNB1, ODC1
48imatinib45 51 1313.0CCND1, FGFR3, CTNNB1, PIK3CA, BRAF
49glycogen45 2612.0APC, CCND1, CTNNB1, AXIN2, AKT1, PIK3CA
50actinomycin d4510.7PIK3CA, BAX, EP300, TP53, AKT1, ODC1

GO Terms for genes affiliated with Colorectal Cancer

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Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:000563411.8MLH3, AURKA, APC, TP53, BRAF, FLCN
2cytosolGO:000582911.8CTNNB1, PIK3CA, AURKA, BUB1B, ODC1, APC
3plasma membraneGO:000588611.5PIK3CA, PTPRJ, APC, DCC, BRAF, FLCN
4beta-catenin destruction complexGO:003087710.9APC, CTNNB1, AXIN2
5lamellipodiumGO:003002710.8CTNNB1, APC, PIK3CA
6centrosomeGO:000581310.8AURKA, APC, CTNNB1, AXIN2
7protein-DNA complexGO:003299310.4CTNNB1, EP300

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:000691511.7DCC, APC, BUB1B, EP300, CTNNB1, BAX
2positive regulation of apoptotic processGO:004306511.6DCC, AKT1, BAX, CTNNB1, APC, FLCN
3negative regulation of transcription from RNA polymerase II promoterGO:000012211.5FLCN, TP53, FGFR3, EP300, CTNNB1, CCND1
4innate immune responseGO:004508711.5PIK3CA, CTNNB1, EP300, NRAS, FGFR3, AKT1
5positive regulation of protein phosphorylationGO:000193411.4CCND1, FLCN, EP300, AKT1, AXIN2
6phosphatidylinositol-mediated signalingGO:004801511.4AURKA, FGFR3, PIK3CA, AKT1, BUB1B
7fibroblast growth factor receptor signaling pathwayGO:000854311.4AKT1, BRAF, FGFR3, NRAS, PIK3CA
8neurotrophin TRK receptor signaling pathwayGO:004801111.4AKT1, NRAS, BRAF, PIK3CA, FGFR3
9negative regulation of cell proliferationGO:000828511.4PTPRJ, TP53, CTNNB1, AXIN2, APC
10blood coagulationGO:000759611.3PTPRJ, TP53, AKT1, NRAS, PIK3CA
11negative regulation of neuron apoptotic processGO:004352411.3NRAS, BRAF, BAX, PIK3CA
12insulin receptor signaling pathwayGO:000828611.3NRAS, PIK3CA, AKT1, FGFR3
13Fc-epsilon receptor signaling pathwayGO:003809511.3AKT1, NRAS, FGFR3, PIK3CA
14epidermal growth factor receptor signaling pathwayGO:000717311.2PIK3CA, NRAS, FGFR3, AKT1
15positive regulation of transcription from RNA polymerase II promoterGO:004594411.2TP53, FLCN, EP300, CTNNB1, AKT1
16protein kinase B signalingGO:004349111.2AKT1, EP300, PIK3CA
17T cell differentiation in thymusGO:003307711.2CTNNB1, TP53, APC
18positive regulation of cell adhesionGO:004578511.2FLCN, APC, PTPRJ
19positive regulation of neuron apoptotic processGO:004352511.2BAX, TP53, FGFR3
20positive regulation of peptidyl-serine phosphorylationGO:003313811.1BRAF, PIK3CA, AKT1
21intrinsic apoptotic signaling pathwayGO:009719311.1BAX, AKT1, TP53
22canonical Wnt signaling pathwayGO:006007011.1APC, CTNNB1, CCND1
23liver developmentGO:000188911.1EP300, CCND1, CTNNB1
24cell proliferationGO:000828311.1BUB1B, TP53, AKT1, AXIN2
25cellular response to hypoxiaGO:007145611.1TP53, EP300, AKT1
26kidney developmentGO:000182211.1ODC1, APC, BAX
27regulation of centromeric sister chromatid cohesionGO:007060211.1CTNNB1, AXIN2
28positive regulation of ERK1 and ERK2 cascadeGO:007037411.1FGFR3, DCC, BRAF
29response to UV-AGO:007014111.1CCND1, AKT1
30neuron migrationGO:000176411.1DCC, BAX, CTNNB1
31canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:004433611.0CTNNB1, APC
32metaphase/anaphase transition of mitotic cell cycleGO:000709111.0BUB1B, APC
33dorsal/ventral axis specificationGO:000995011.0AXIN2, CTNNB1
34positive regulation of protein oligomerizationGO:003246111.0TP53, BAX
35mitotic G1 DNA damage checkpointGO:003157111.0TP53, CCND1
36mitotic cell cycleGO:000027811.0AURKA, CCND1, BUB1B, EP300
37negative regulation of cell growthGO:003030811.0FLCN, PTPRJ, TP53
38striated muscle cell differentiationGO:005114610.9AKT1, NRAS
39Notch signaling pathwayGO:000721910.9EP300, CCND1, TP53
40lens morphogenesis in camera-type eyeGO:000208910.9FGFR3, CTNNB1
41response to salt stressGO:000965110.9BAX, TP53
42negative regulation of apoptotic signaling pathwayGO:0200123410.8BAX, CTNNB1
43spindle organizationGO:000705110.7BUB1B, AURKA
44response to X-rayGO:001016510.7TP53, CCND1
45positive regulation of cell deathGO:001094210.7AXIN2, EP300
46apoptotic mitochondrial changesGO:000863710.6BAX, AKT1
47intrinsic apoptotic signaling pathway by p53 class mediatorGO:007233210.4TP53, BAX

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:000551512.4FGFR3, PIK3CA, MLH3, AURKA, PTPRJ, BUB1B
2ATP bindingGO:000552411.4PIK3CA, MLH3, AURKA, BUB1B, TP53, BRAF
3protein kinase bindingGO:001990111.4AURKA, PTPRJ, APC, TP53, CCND1, CTNNB1
4protein complex bindingGO:003240311.2FLCN, EP300, CCND1, NRAS, CTNNB1
5protein kinase activityGO:000467211.2AURKA, BUB1B, BRAF, AKT1, CCND1
6enzyme bindingGO:001989911.2TP53, AKT1, CCND1, CTNNB1, AXIN2
7identical protein bindingGO:004280211.1TP53, DCC, BRAF, AKT1, BAX
8beta-catenin bindingGO:000801311.1AXIN2, EP300, APC, PTPRJ
9transcription factor bindingGO:000813411.0TP53, EP300, CCND1, CTNNB1
10protein serine/threonine kinase activityGO:000467411.0AKT1, BRAF, BUB1B, PIK3CA
11chromatin bindingGO:000368210.8CTNNB1, EP300, TP53, MLH3
12I-SMAD bindingGO:007041110.7AXIN2, CTNNB1
13gamma-catenin bindingGO:004529510.7PTPRJ, APC
14mitogen-activated protein kinase bindingGO:005101910.7EP300, PTPRJ
15nuclear hormone receptor bindingGO:003525710.4CTNNB1, EP300

Products for genes affiliated with Colorectal Cancer

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Sources for Colorectal Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
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