MCID: CLR023
MIFTS: 73

Colorectal Cancer malady

Cancer diseases category

Summaries for Colorectal Cancer

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

MalaCards: Colorectal Cancer, also known as colorectal carcinoma, is related to breast cancer and lynch syndrome. An important gene associated with Colorectal Cancer is MCC (mutated in colorectal cancers), and among its related pathways are Colorectal Cancer Metastasis and Pathways in cancer. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and colon, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia:63 Colorectal cancer (also known as colon cancer, rectal cancer, bowel cancer or colorectal adenocarcinoma)... more...

Description from OMIM:46 114500

Aliases & Classifications for Colorectal Cancer

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Sources:
63Wikipedia, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

colorectal cancer 63 46 10 44 33 60
colorectal carcinoma 44 60


Related Diseases for Colorectal Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Colorectal Cancer family:

Familial Colorectal Cancer Colorectal Cancer 6
Colorectal Cancer 2 Colorectal Cancer 1
Colorectal Cancer 5 Colorectal Cancer 7
Colorectal Cancer 12 Colorectal Cancer 8
Colorectal Cancer 4 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.5CCND1, CTNNB1, BAX, MSH6, TP53
2lynch syndrome31.5PMS2, MSH6
3colon cancer31.4CCND1, BRAF, CTNNB1, PPARD, BAX, AXIN2
4adenoma31.3TLR4, BRAF, CCND1, PMS2, CTNNB1, PPARD
5hepatitis31.3TLR2
6lung cancer31.1CCND1, BRAF, TLR4, BAX, MCC, SMAD7
7ulcerative colitis31.0TP53
8familial adenomatous polyposis31.0TP53, MSH6, PLA2G2A, MCC, AXIN2, PPARD
9prostate cancer30.9CTNNB1, PDGFRL, CCND1, PMS2, PMS1, PPARD
10peritonitis30.9TLR2
11adenocarcinoma30.8PMS2, CCND1, BRAF, CTNNB1, BAX, PLA2G2A
12inflammatory bowel disease30.8SMAD7, PLA2G2A, TLR2, TLR4
13ovarian cancer30.8PMS2, CCND1, BRAF, CTNNB1, BAX, MSH6
14melanoma30.8PMS1, PMS2, CCND1, BRAF, TLR4, CTNNB1
15pancreatic cancer30.8CCND1, BRAF, CTNNB1, BAX, PLA2G2A, SMAD7
16pancreatitis30.7PLA2G2A
17leukemia30.5TP53, PLA2G2A, BAX, TLR2, TLR4, CCND1
18esophageal cancer30.5CCND1, TP53
19hepatocellular carcinoma30.4CCND1, TLR4, TLR2, CTNNB1, PPARD, BAX
20hepatitis c30.4TLR2, TLR4
21retinoblastoma30.4PMS1, CCND1, BAX, SMAD7, TP53
22endometrial carcinoma30.4BRAF, CTNNB1, TP53
23muir-torre syndrome30.3MSH6
24stomach cancer30.3TP53
25squamous cell carcinoma30.3PMS1, CCND1, CTNNB1, PPARD, MT-CO1, BAX
26gastritis30.3TP53, TLR2, TLR4
27myeloid leukemia30.3BAX, TLR4
28lung adenocarcinoma30.1CCND1, BRAF, CTNNB1, BAX, TP53
29ischemia30.1PLA2G2A, BAX, MT-CO1
30colon adenocarcinoma30.1CTNNB1, BAX, SMAD7
31thyroid cancer30.1TP53, BRAF, CCND1
32cholangiocarcinoma30.1BRAF, TP53
33turcot syndrome30.1PMS2, MSH6
34peutz-jeghers syndrome30.1CTNNB1, PMS1
35sarcoma30.1BRAF, TP53
36rhabdomyosarcoma30.1TP53
37neuroblastoma30.1TP53
38leiomyosarcoma30.1TP53
39glioblastoma multiforme29.9PMS2, CCND1, TLR4, BAX, TP53
40gallbladder cancer29.9TP53
41non-small cell lung carcinoma29.9TP53, BAX, BRAF, CCND1
42cervical cancer29.9BRAF, BAX, TP53
43astrocytoma29.9PLA2G2A, TP53
44acute pancreatitis29.9PLA2G2A, TLR4
45diabetes mellitus29.9PPARD
46papilloma29.9TP53
47myocardial infarction29.9PPARD
48pneumonia29.9TLR2, TLR4
49hepatitis b29.9TLR4
50vascular cancer11.0

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Clinical Features for Colorectal Cancer

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46OMIM
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Clinical features from OMIM:

114500

Clinical synopsis from OMIM:

114500

Drugs & Therapeutics for Colorectal Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colorectal Cancer

Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Search CenterWatch for Colorectal Cancer

Genetic Tests for Colorectal Cancer

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Anatomical Context for Colorectal Cancer

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32MalaCards
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MalaCards organs/tissues related to Colorectal Cancer:

32
Liver, Breast, Colon, Endothelial, Testes, Lymph node, Lung, Prostate, T cells, Appendix, Bone, Brain, Monocytes, Bone marrow, Thyroid, Myeloid, Skin, Testis, Whole blood, Pancreas, Eye, Fetal liver, B cells, Heart, Nk cells, Smooth muscle, Cervix, Small intestine, Kidney, Placenta, Pituitary

Animal Models for Colorectal Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colorectal Cancer:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538413.9TLR2, TLR4, BRAF, CCND1, PMS2, CTNNB1
2MP:001076813.9TLR2, TLR4, BRAF, CCND1, PMS2, CTNNB1
3MP:000200613.7TP53, PMS1, PMS2, CCND1, BRAF, TLR4
4MP:000538713.4PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
5MP:000538613.0CCND1, BRAF, TLR4, TLR2, CTNNB1, PPARD
6MP:000538913.0CCND1, BRAF, TLR4, CTNNB1, PPARD, MLH3
7MP:000538112.9PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
8MP:000538512.7CCND1, BRAF, TLR4, TLR2, CTNNB1, MT-CO1
9MP:000536912.6BRAF, TLR4, TLR2, CTNNB1, MT-CO1, BAX
10MP:000537812.6CCND1, BRAF, TLR4, TLR2, CTNNB1, PPARD
11MP:000539112.6CCND1, BRAF, TLR4, CTNNB1, DCC, BAX
12MP:000539712.5PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
13MP:000537912.4PMS2, CCND1, TLR2, MLH3, BAX, AXIN2
14MP:001077112.4CCND1, TLR4, TLR2, CTNNB1, PPARD, SMAD7
15MP:000537612.4PMS2, TLR4, TLR2, PPARD, MT-CO1, MSH6
16MP:000537011.9TLR4, TLR2, CTNNB1, PPARD, TP53, BRAF
17MP:000538811.7CCND1, CTNNB1, BAX, TP53
18MP:000363111.4TLR4, DCC, BAX, AXIN2
19MP:000539011.3CCND1, BAX, AXIN2

Publications for Colorectal Cancer

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50PubMed
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Articles related to Colorectal Cancer:

(show top 50)    (show all 7752)
idTitleAuthorsYear
1
Comparative N-Glycan Profiling of Colorectal Cancer Cell Lines Reveals Unique Bisecting GlcNAc and I+-2,3-Linked Sialic Acid Determinants Are Associated with Membrane Proteins of the More Metastatic/Aggressive Cell Lines. (24295106)
2014
2
Incidence and risk factors of chylous ascites after colorectal cancer surgery. (23856087)
2013
3
Expression of ZNF148 in different developing stages of colorectal cancer and its prognostic value: a large Chinese study based on tissue microarray. (23576061)
2013
4
Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. (22965873)
2013
5
Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. (23505554)
2013
6
The potential role of ORM2 in the development of colorectal cancer. (22363757)
2012
7
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. (22159220)
2012
8
A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer. (21550229)
2011
9
Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. (21456008)
2011
10
Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing. (21483104)
2011
11
KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. (21424126)
2011
12
Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients. (21573768)
2011
13
p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population. (21461655)
2011
14
TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer. (21179245)
2010
15
The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker. (21059221)
2010
16
A novel K-ras mutation in colorectal cancer. A case report and literature review. (19661358)
2009
17
Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer. (19229543)
2009
18
Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target. (19450179)
2009
19
Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. (19147569)
2009
20
KRAS mutations and epidermal growth factor receptor inhibitor therapy in metastatic colorectal cancer. (19297803)
2009
21
ABCB1 gene polymorphisms and haplotype analysis in colorectal cancer. (19415305)
2009
22
Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. (19700418)
2009
23
Adenovirus-mediated expression of SSAT inhibits colorectal cancer cell growth in vitro. (18430370)
2008
24
Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480. (18855981)
2008
25
Prognostic relevance of occult nodal micrometastases and circulating tumor cells in colorectal cancer in a prospective multicenter trial. (19010855)
2008
26
Signal-dependent regulation of gene expression as a target for cancer treatment: inhibiting p38alpha in colorectal tumors. (18395970)
2008
27
Analysis of specific transcriptional regulators as early predictors of independent prognostic relevance in resected colorectal cancer. (17317820)
2007
28
No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cells with multiple KRAS mutations. (17697521)
2007
29
A genome wide linkage analysis in Swedish families with hereditary non-familial adenomatous polyposis/non-hereditary non-polyposis colorectal cancer. (16150854)
2006
30
Altered expression of CDX2 in colorectal cancers. (16499661)
2006
31
Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. (16512993)
2006
32
Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. (16477629)
2006
33
Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. (17029629)
2006
34
Brain metastasis from colorectal cancer. (15309466)
2005
35
Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain. (16270383)
2005
36
Normal and modified urinary nucleosides represent novel biomarkers for colorectal cancer diagnosis and surgery monitoring. (16336453)
2005
37
Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. (15611135)
2005
38
Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot. (15480874)
2004
39
Breast and colorectal cancer risk communication approaches with low-income African-American and Hispanic women: implications for healthcare providers. (15160974)
2004
40
Genotyping possible polymorphic variants of human mismatch repair genes in healthy Korean individuals and sporadic colorectal cancer patients. (15340264)
2004
41
Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells. (15623600)
2004
42
Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis. (12529167)
2003
43
Capecitabine: indications and future perspectives in the treatment of metastatic colorectal and breast cancer. (11989587)
2001
44
Genetic analysis of the APC gene regions involved in attenuated APC phenotype in Israeli patients with early onset and familial colorectal cancer. (11506490)
2001
45
NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal cancer cells. (11045427)
2000
46
BAT-26 identifies sporadic colorectal cancers with mutator phenotype: a correlative study with clinico-pathological features and mutations in mismatch repair genes. (10419591)
1999
47
Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. (10334520)
1999
48
CD44 expression in the stromal matrix of colorectal cancer: association with prognosis. (9516948)
1998
49
Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability. (8932328)
1996
50
Significance of MUC1 and MUC2 mucin expression in colorectal cancer. (8813954)
1996

Genetic Variations for Colorectal Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Colorectal Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colorectal Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Colorectal Cancer

Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 59Tocris Bioscience, 53Reactome, 55SinoBiological
See all sources

Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.9TP53, CCND1, MSH6, AXIN2, BAX, DCC
212.6CCND1, BRAF, CTNNB1, PPARD, DCC, BAX
3
Hide members
12.6MSH6, AXIN2, BAX, DCC, PPARD, CTNNB1
412.2CCND1, BRAF, CTNNB1, BAX, MSH6, SMAD7
511.9CCND1, BRAF, TLR4, TLR2, CTNNB1, TP53
6
Hide members
11.9CCND1, CTNNB1, PPARD, BAX, AXIN2, TP53
7
Hide members
11.7CCND1, TLR4, TLR2, BAX, TP53
8
Hide members
11.7TP53, BAX, TLR2, TLR4, CCND1
9
Hide members
11.7CCND1, BRAF, TLR4, TLR2, BAX
1011.7CCND1, CTNNB1, DCC, BAX, TP53
1111.7CCND1, CTNNB1, AXIN2, SMAD7, TP53
12
Hide members
11.7TP53, AXIN2, PPARD, CTNNB1, CCND1
1311.4TP53, PLA2G2A, TLR4, CCND1
1411.4CCND1, CTNNB1, BAX, TP53
1511.4CCND1, BRAF, CTNNB1, TP53
1611.4TP53, CTNNB1, BRAF, CCND1
17
Hide members
11.4TP53, BAX, CTNNB1, BRAF
18
Hide members
11.4CCND1, BAX, MSH6, TP53
1911.4TP53, PPARD, CTNNB1, CCND1
2011.4SMAD7, AXIN2, CTNNB1, CCND1
21
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11.2CCND1, BAX, TP53
22
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11.2TP53, BAX, CCND1
23
Hide members
11.2CCND1, BRAF, TP53
24
Hide members
11.2BRAF, BAX, TP53
25
Hide members
11.2TLR2, TLR4, BRAF
26
Hide members
11.2TLR2, TLR4, BRAF
2711.2TP53, BAX, PMS2
28
Hide members
11.2TP53, MSH6, BRAF
29
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
11.2BAX, AXIN2, TP53
3011.2AXIN2, CTNNB1, CCND1
3111.2CCND1, CTNNB1, PPARD
32
Hide members
11.2MLH3, PMS2, PMS1
33
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11.0TLR2, TLR4

Compounds for genes affiliated with Colorectal Cancer

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1vegf4413.3BRAF, CCND1, TLR4, TLR2, CTNNB1, PPARD
2retinoic acid44 2414.1TP53, BRAF, TLR4, CCND1, TLR2, PLA2G2A
3tyrosine4413.0PPARD, CCND1, BRAF, TLR4, SMAD7, CTNNB1
4sb 20358044 5913.9CCND1, BRAF, TLR4, TLR2, BAX, CTNNB1
5cisplatin44 49 59 1115.8CCND1, BRAF, TP53, TLR4, CTNNB1, BAX
6n acetylcysteine4412.6CTNNB1, BAX, SMAD7, TP53, TLR4, CCND1
7ly2940024412.6CTNNB1, TLR4, PLA2G2A, TP53, CCND1, BAX
8paraffin4412.6PMS2, CCND1, BRAF, CTNNB1, BAX, MSH6
9phosphatidylinositol4412.5BAX, CTNNB1, CCND1, TLR4, BRAF, TLR2
10crcs4412.4BRAF, CTNNB1, CCND1, MSH6, TP53, PMS2
11pd 98,0594412.3TLR2, SMAD7, BAX, CTNNB1, BRAF, CCND1
12wortmannin4412.3CTNNB1, TLR2, TLR4, BRAF, CCND1, BAX
13actinomycin d4412.3TLR4, BAX, PLA2G2A, SMAD7, TLR2, TP53
14fatty acid4412.3PLA2G2A, BRAF, TLR2, CTNNB1, PPARD, MT-CO1
15sulindac44 1113.1TP53, BAX, PPARD, CTNNB1, CCND1
16palmitate4412.1PPARD, TLR2, TLR4, CTNNB1, PLA2G2A
17paclitaxel44 49 1114.1BRAF, CCND1, BAX, TP53, CTNNB1
18retinoid4412.1PPARD, BAX, TP53, CTNNB1, CCND1
19serine4412.1CCND1, PLA2G2A, TLR4, TLR2, AXIN2
20doxorubicin44 49 1113.9CCND1, TP53, MSH6, BAX, CTNNB1
21exisulind4411.9PPARD, BAX, CTNNB1, CCND1
22sulindac sulfide4411.9TP53, BAX, PPARD, CCND1
23docosahexaenoic acid44 28 2413.9TLR4, TLR2, PPARD, PLA2G2A
24indole-3-carbinol4411.9BAX, CTNNB1, CCND1, TP53
25c2ceramide4411.8TP53, BAX, TLR4, PLA2G2A
26adpribose4411.8TP53, CTNNB1, CCND1, BAX
27geldanamycin44 49 59 1114.8CTNNB1, BRAF, CCND1, TP53
28sp 60012544 5912.8TP53, TLR2, CCND1, BAX
29gf 109203x44 5912.7TLR2, CCND1, CTNNB1, PLA2G2A
30adriamycin4411.7CCND1, TP53, BAX, CTNNB1
31genistein44 28 59 2 11 2416.7BAX, PLA2G2A, TLR4, CCND1, CTNNB1
32mg 13244 5912.7CTNNB1, TP53, BAX, CCND1
33oligonucleotide4411.6CTNNB1, CCND1, TP53, SMAD7, PPARD, BRAF
34tgf beta14411.6SMAD7, CTNNB1, TLR4, CCND1
35quercetin44 59 11 2414.6PLA2G2A, CTNNB1, BAX, CCND1
36olomoucine44 1112.6BAX, TP53, CCND1
37o6-methylguanine4411.5MSH6, TP53, BRAF
38cetuximab44 49 1113.5CTNNB1, CCND1, BRAF
39depsipeptide4411.4TP53, CCND1
40bbr34644411.3BAX, TP53
41pidotimod4411.3AXIN2, CTNNB1
42inostamycin4411.3BAX, CCND1
43h2o24411.2PLA2G2A, CTNNB1
44arabinogalactan4411.2TLR2, TLR4
45sb-2167634411.2CCND1, CTNNB1
46cycloheximide4411.2TLR2
47dutp4411.1BAX, CCND1, TP53
48chlorophyllin4411.1CCND1, CTNNB1
49mhs-24411.0PMS2, PMS1
50samp4411.0CTNNB1, AXIN2

GO Terms for genes affiliated with Colorectal Cancer

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16Gene Ontology
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Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1PMS1, PMS2, CCND1, BRAF, CTNNB1, PPARD
2mismatch repair complexGO:03230011.3MLH3, PMS2, PMS1
3MutLalpha complexGO:03238911.0PMS2, PMS1
4beta-catenin destruction complexGO:03087711.0AXIN2, CTNNB1
5catenin complexGO:01634210.9CTNNB1, SMAD7

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629811.8MSH6, MLH3, PMS2, PMS1
2reciprocal meiotic recombinationGO:00713111.8PMS1, PMS2, MLH3, MSH6
3ATP catabolic processGO:00620011.8MSH6, MLH3, PMS2, PMS1
4positive regulation of apoptotic processGO:04306511.6CTNNB1, DCC, BAX, TP53
5positive regulation of inflammatory responseGO:05072911.5TLR4, TLR2, PLA2G2A
6intrinsic apoptotic signaling pathwayGO:09719311.5BAX, MSH6, TP53
7regulation of centromeric sister chromatid cohesionGO:07060211.3AXIN2, CTNNB1
8somatic recombination of immunoglobulin gene segmentsGO:01644711.3MSH6, PMS2
9maintenance of DNA repeat elementsGO:04357011.3MSH6, AXIN2
10positive regulation of macrophage cytokine productionGO:06090711.3TLR2, TLR4
11cellular response to lipoteichoic acidGO:07122311.2TLR4, TLR2
12adherens junction assemblyGO:03433311.2CTNNB1, SMAD7
13negative regulation of interleukin-17 productionGO:03270011.2TLR2, TLR4
14positive regulation of protein oligomerizationGO:03246111.2TP53, BAX
15positive regulation of tumor necrosis factor biosynthetic processGO:04253511.2TLR4, TLR2
16mitotic G1 DNA damage checkpointGO:03157111.2CCND1, TP53
17dorsal/ventral axis specificationGO:00995011.1CTNNB1, AXIN2
18positive regulation of nitric-oxide synthase biosynthetic processGO:05177011.1TLR4, TLR2
19somatic hypermutation of immunoglobulin genesGO:01644611.0PMS2, MSH6
20I-kappaB phosphorylationGO:00725211.0TLR4, TLR2
21response to salt stressGO:00965111.0TP53, BAX
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.9BRAF, TLR4, DCC
23determination of adult lifespanGO:00834010.9TP53, MSH6

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.2PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
2ATPase activityGO:01688711.5MSH6, MLH3, PMS2, PMS1
3protein kinase bindingGO:01990111.4TP53, AXIN2, CTNNB1, CCND1
4MutSalpha complex bindingGO:03240711.4MLH3, PMS2, PMS1
5I-SMAD bindingGO:07041111.4SMAD7, AXIN2, CTNNB1
6mismatched DNA bindingGO:03098311.3PMS1, MLH3, MSH6
7enzyme bindingGO:01989911.1CCND1, CTNNB1, AXIN2, TP53
8single-stranded DNA bindingGO:00369711.1MLH3, PMS2, PMS1
9lipopolysaccharide receptor activityGO:00187511.0TLR4, TLR2

Products for genes affiliated with Colorectal Cancer

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Colorectal Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet