MCID: CLR023
MIFTS: 77

Colorectal Cancer malady

Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases categories

Summaries for Colorectal Cancer

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OMIM:46 Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and... (114500) more...

MalaCards based summary: Colorectal Cancer, also known as colorectal carcinoma, is related to lynch syndrome and adenoma, and has symptoms including uterine leiomyosarcoma, renal cell carcinoma and hereditary nonpolyposis colorectal carcinoma. An important gene associated with Colorectal Cancer is CCND1 (cyclin D1), and among its related pathways are Colorectal Cancer Metastasis and Proteoglycans in cancer. The compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include the colon, the rectum and liver, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:9 A large intestine cancer that is located in the colon and/or located in the rectum.

MedlinePlus:33 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

Wikipedia:64 Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is the development of... more...

Aliases & Classifications for Colorectal Cancer

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Colorectal Cancer, Aliases & Descriptions:

Name: Colorectal Cancer 31 9 64 46 11 44 33 61
 
Colorectal Carcinoma 44 61


Classifications:



External Ids:

Disease Ontology9 DOID:9256
OMIM46 114500
MeSH34 D015179

Related Diseases for Colorectal Cancer

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Diseases in the Colorectal Cancer family:

Familial Colorectal Cancer Colorectal Cancer 6
Colorectal Cancer 2 Colorectal Cancer 1
Colorectal Cancer 5 Colorectal Cancer 7
Colorectal Cancer 12 Colorectal Cancer 8
Colorectal Cancer 4 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1lynch syndrome32.6PMS2, MSH6
2adenoma32.0TLR4, PMS2, TP53, BRAF, MSH6, CCND1
3breast cancer31.9CTNNB1, CCND1, PIK3CA
4ovarian cancer31.9PIK3CA, PMS2, TP53, BRAF, MSH6, CCND1
5familial adenomatous polyposis31.9PMS2, TP53, BRAF, MSH6, CCND1, PLA2G2A
6adenocarcinoma31.8PIK3CA, PMS2, TP53, BRAF, MSH6, CCND1
7colorectal cancer, somatic31.5PIK3CA, MLH3, DCC, PDGFRL, CTNNB1
8lung cancer31.5CCND1, BRAF, TP53, TLR4, PIK3CA
9melanoma31.4PIK3CA, TLR4, PMS2, TP53, BRAF, CCND1
10endometrial carcinoma31.4CTNNB1, BRAF, TP53
11muir-torre syndrome31.4MSH6
12turcot syndrome31.4PMS2, MSH6
13lung adenocarcinoma31.3PIK3CA, TP53, BRAF, CCND1, CTNNB1
14stomach cancer31.3PIK3CA, TP53, BRAF, CCND1, CTNNB1
15cholangiocarcinoma31.2PIK3CA, TP53, BRAF
16colitis31.2TLR2, TLR4, PLA2G2A
17prostate cancer31.1PIK3CA, PMS2, TP53, MSH6, CCND1, MT-CO1
18pancreatic cancer31.1PIK3CA, TP53, BRAF, CCND1, PLA2G2A, CTNNB1
19squamous cell carcinoma of the head and neck31.0CCND1, TP53, PIK3CA
20non-small cell lung carcinoma30.9CCND1, BRAF, TP53
21glioblastoma30.8PIK3CA, TLR4, PMS2, TP53, CCND1
22gastritis30.7TLR2, TLR4, TP53
23leukemia30.7PIK3CA, TLR2, TLR4, TP53, CCND1, PLA2G2A
24liver cancer30.5PIK3CA, TLR2, TLR4, TP53, CCND1, CTNNB1
25familial colorectal cancer11.1
26breast and colorectal cancer11.0
27endotheliitis11.0
28hepatitis10.9
29colonic benign neoplasm10.8PIK3CA, TP53, BRAF, MSH6, CCND1, CTNNB1
30thyroid cancer, anaplastic10.8PIK3CA, TP53, BRAF, CTNNB1
31colon cancer10.8
32thyroid hurthle cell carcinoma10.7PIK3CA, TP53, BRAF, CCND1
33malignant glioma10.7MSH6, BRAF, TP53, PMS2, PIK3CA
34hypoxia10.7
35ulcerative colitis10.7
36papillary thyroid carcinoma10.7CTNNB1, CCND1, BRAF
37ovarian cancer, somatic10.7PIK3CA, CTNNB1
38hepatocellular carcinoma, somatic10.7PIK3CA, CTNNB1
39spitz nevus10.7BRAF
40peritonitis10.6
41prostatitis10.6
42inflammatory bowel disease10.6
43medulloblastoma10.6PIK3CA, TP53, CTNNB1
44colorectal adenoma10.6
45craniopharyngioma10.6CTNNB1
46pancreatitis10.6
47malignant mixed mullerian tumor10.6CTNNB1, TP53
48breast cancer, invasive ductal10.5TP53, CCND1
49gastric cancer10.5
50bladder carcinoma10.5CCND1, TP53, TLR2, PIK3CA

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Symptoms for Colorectal Cancer

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Symptoms by clinical synopsis from OMIM:

114500

Clinical features from OMIM:

114500

HPO human phenotypes related to Colorectal Cancer:

id Description Frequency HPO Source Accession
1 uterine leiomyosarcoma HP:0002891
2 renal cell carcinoma HP:0005584
3 hereditary nonpolyposis colorectal carcinoma HP:0006716
4 transitional cell carcinoma of the bladder HP:0006740
5 neoplasm of the stomach HP:0006753

Drugs & Therapeutics for Colorectal Cancer

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Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Genetic Tests for Colorectal Cancer

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Anatomical Context for Colorectal Cancer

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MalaCards organs/tissues related to Colorectal Cancer:

32
Liver, Colon, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Prostate, Bone, Brain, Myeloid, Bone marrow, Monocytes, Skin, Testis, Whole blood, Neutrophil, Pancreas, Thyroid, Pituitary, Eye, Heart, Smooth muscle, Small intestine, Placenta, Nk cells, B cells, Fetal liver, Appendix

FMA organs/tissues related to Colorectal Cancer:

15
The colon, The rectum

Animal Models for Colorectal Cancer or affiliated genes

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MGI Mouse Phenotypes related to Colorectal Cancer:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.5CTNNB1, PIK3CA, TLR2, TLR4, PMS2, TP53
2MP:000538411.4PMS2, TLR4, TLR2, PIK3CA, TP53, DCC
3MP:000537611.3PIK3CA, TLR2, TLR4, PMS2, TP53, BRAF
4MP:000538111.3TLR2, TLR4, PMS2, TP53, DCC, BRAF
5MP:000537911.2PIK3CA, MLH3, TLR2, PMS2, TP53, BRAF
6MP:001077111.2PIK3CA, TLR2, TLR4, TP53, BRAF, MSH6
7MP:000538911.2PIK3CA, MLH3, TLR4, PMS2, TP53, BRAF
8MP:000538711.2PIK3CA, TLR2, TLR4, PMS2, TP53, BRAF
9MP:001076811.2PIK3CA, TLR2, TLR4, PMS2, TP53, DCC
10MP:000538811.2TLR2, TLR4, TP53, DCC, BRAF, CCND1
11MP:000539111.1PIK3CA, TLR4, TP53, DCC, BRAF, CCND1
12MP:000536911.1PIK3CA, TLR2, TLR4, TP53, BRAF, MT-CO1
13MP:000538511.1PIK3CA, TLR2, TLR4, TP53, BRAF, CCND1
14MP:000118611.1TLR4, TP53, DCC, BRAF, CTNNB1
15MP:000537811.0TLR2, TLR4, TP53, BRAF, CCND1, MT-CO1
16MP:000538611.0PIK3CA, TLR2, TLR4, TP53, DCC, BRAF
17MP:000363110.9PIK3CA, TLR2, TLR4, TP53, DCC, BRAF
18MP:000537510.8PIK3CA, TLR2, TLR4, TP53, BRAF
19MP:000539010.5TLR2, TLR4, TP53, BRAF, CCND1, CTNNB1

Publications for Colorectal Cancer

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Articles related to Colorectal Cancer:

(show top 50)    (show all 7779)
idTitleAuthorsYear
1
The effect of oxoguanine glycosylase 1 rs1052133 polymorphism on colorectal cancer risk in Caucasian population. (23975367)
2014
2
E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells. (24369055)
2013
3
Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. (23797051)
2013
4
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
5
Metachronous colorectal cancer: A competing risks analysis with consideration for a stratified approach to surveillance colonoscopy. (24272767)
2013
6
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing. (24284403)
2013
7
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry. (23745025)
2013
8
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
9
Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. (23226332)
2012
10
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. (23033949)
2012
11
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer. (22699826)
2012
12
Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer. (22351690)
2012
13
Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression. (21806965)
2011
14
Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome. (20584785)
2010
15
BRAF mutation predicts resistance to anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer. (20514492)
2010
16
High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. (19856313)
2010
17
A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. (19616522)
2009
18
Individualized therapies in colorectal cancer: KRAS as a marker for response to EGFR-targeted therapy. (19386128)
2009
19
P53 and EGFR expression in colorectal cancer: a reappraisal of 'old' tissue markers in patients with long follow-up. (19331236)
2009
20
High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. (19418581)
2009
21
Invasion front-specific overexpression of tissue inhibitor of metalloproteinase-1 in liver metastases from colorectal cancer. (18630499)
2008
22
An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. (17785764)
2008
23
KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors. (19378369)
2008
24
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (18381954)
2008
25
Galectin-3 expression in colorectal cancer: relation to invasion and metastasis. (17695516)
2007
26
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
27
Genetic testing in colorectal cancer: who, when, how and why. (17392593)
2007
28
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. (16804544)
2006
29
Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples. (15956025)
2006
30
Expression of maspin in colorectal cancer. (17203770)
2006
31
Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. (16491830)
2005
32
Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. (15041737)
2004
33
High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. (15534108)
2004
34
The role of new agents in the treatment of colorectal cancer. (15031593)
2004
35
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule. (15550581)
2004
36
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. (15355920)
2004
37
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
38
Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. (14968945)
2003
39
Significance of transforming growth factor beta1 as a new tumor marker for colorectal cancer. (11802214)
2002
40
Enhanced 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in human colorectal cancer not expressing low density lipoprotein receptor. (10226581)
1999
41
Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients. (10206298)
1999
42
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. (10490837)
1999
43
Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. (9683794)
1998
44
Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. (9615749)
1998
45
Soluble CD44 and CD44v6 serum levels in patients with colorectal cancer are independent of tumor stage and tissue expression of CD44v6. (9625129)
1998
46
Beta-catenin mutations in cell lines established from human colorectal cancers. (9294210)
1997
47
Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines. (8712692)
1996
48
APC mutation analysis in sporadic colorectal cancer]. (9387290)
1996
49
Colonoscopy in relation to the evolving genetics of familial colorectal cancer. (7601034)
1995
50
Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. (7874129)
1994

Variations for Colorectal Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer:

63 (show all 17)
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052
10PIK3CAp.Arg38HisVAR_026166
11PIK3CAp.Gly106ValVAR_026168
12PIK3CAp.Cys420ArgVAR_026171
13PIK3CAp.Glu453GlnVAR_026172
14PIK3CAp.Glu542LysVAR_026173
15PIK3CAp.Glu545LysVAR_026178
16PIK3CAp.Met1043IleVAR_026190
17PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Colorectal Cancer:

7
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.974G> T (p.Gly325Val)single nucleotide variantPathogenicrs121912659GRCh37Chr 17, 7576872: 7576872
2TP53NM_000546.5(TP53): c.566C> T (p.Ala189Val)single nucleotide variantPathogenicrs121912665GRCh37Chr 17, 7578283: 7578283
3PLA2G2ANM_000300.3(PLA2G2A): c.144_145delTG (p.Cys48Trpfs)deletionPathogenicGRCh37Chr 1, 20304913: 20304914
4MT-CO2m.8009G> Asingle nucleotide variantPathogenicrs199474826GRCh37Chr MT, 8009: 8009
5MT-CO1m.6264G> Asingle nucleotide variantPathogenicrs267606882GRCh37Chr MT, 6264: 6264
6MT-CO1m.6277G> Asingle nucleotide variantPathogenicGRCh37Chr MT, 6277: 6277
7MT-CO1m.7275T> Csingle nucleotide variantPathogenicGRCh37Chr MT, 7275: 7275
8MT-CYBm.14985G> Asingle nucleotide variantPathogenicrs207459995GRCh37Chr MT, 14985: 14985
9MT-CYBm.15572T> Csingle nucleotide variantPathogenicrs207459996GRCh37Chr MT, 15572: 15572
10MT-ND4Lm.10563T> Csingle nucleotide variantPathogenicrs267606892GRCh37Chr MT, 10563: 10563

Expression for genes affiliated with Colorectal Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Colorectal Cancer patients vs. healthy controls: 31 (show all 502)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CDH3cadherin 3, type 1, P-cadherin (placental)Colon+6.140.000
2HCAR3hydroxycarboxylic acid receptor 3Colon+5.600.000
3INHBAinhibin, beta AColon+5.560.000
4IL8interleukin 8Colon+5.260.000
5COL12A1collagen, type XII, alpha 1Colon+4.840.000
6CEMIPcell migration inducing protein, hyaluronan bindingColon+4.630.008
7AQP8aquaporin 8Colon-4.440.039
8GREM1gremlin 1, DAN family BMP antagonistColon+4.370.002
9SSTsomatostatinColon-4.310.011
10FAM3Bfamily with sequence similarity 3, member BColon+4.100.023
11PYYpeptide YYColon-4.030.042
12CXCL5chemokine (C-X-C motif) ligand 5Colon+3.970.004
13KRT23keratin 23 (histone deacetylase inducible)Colon+3.960.017
14MT1Mmetallothionein 1MColon-3.930.013
15BEST4bestrophin 4Colon-3.900.021
16DPEP1dipeptidase 1 (renal)Colon+3.880.039
17COL11A1collagen, type XI, alpha 1Colon+3.860.007
18TAC1tachykinin, precursor 1Colon+3.830.031
19S100A2S100 calcium binding protein A2Colon+3.800.013
20INSL5insulin-like 5Colon-3.760.048
21KRT6Bkeratin 6BColon+3.730.002
22MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Colon+3.630.044
23CA7carbonic anhydrase VIIColon-3.630.024
24SOX5SRY (sex determining region Y)-box 5Colon-3.580.001
25IGLimmunoglobulin lambda locusColon-3.530.020
26MMP10matrix metallopeptidase 10 (stromelysin 2)Colon+3.460.023
27LCN2lipocalin 2Colon+3.420.003
28PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaColon-3.420.007
29TTLL5tubulin tyrosine ligase-like family, member 5Colon-3.360.010
30VSTM2AV-set and transmembrane domain containing 2AColon-3.340.022
31PPP1R10protein phosphatase 1, regulatory subunit 10Blood+3.310.000
32CRNDEcolorectal neoplasia differentially expressed (non-protein coding)Colon+3.300.013
33CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Colon+3.290.003
34CHDHcholine dehydrogenaseColon+3.280.012
35MUC5ACmucin 5AC, oligomeric mucus/gel-formingColon+3.280.044
36MTRF1mitochondrial translational release factor 1Colon+3.250.006
37TMCO5Btransmembrane and coiled-coil domains 5B, pseudogeneColon-3.240.008
38CCDC3coiled-coil domain containing 3Colon+3.220.022
39SPIBSpi-B transcription factor (Spi-1/PU.1 related)Colon-3.150.025
40SCGB2A2secretoglobin, family 2A, member 2Colon-3.150.045
41OR6A2olfactory receptor, family 6, subfamily A, member 2Colon-3.140.001
42TUBB1tubulin, beta 1 class VIColon+3.140.002
43MCM10minichromosome maintenance complex component 10Colon+3.140.001
44KRT80keratin 80Colon+3.130.016
45DUOX2dual oxidase 2Colon+3.100.018
46IL17Finterleukin 17FColon+3.100.000
47MMP7matrix metallopeptidase 7 (matrilysin, uterine)Colon+3.090.041
48CFIcomplement factor IColon+3.070.027
49OGNosteoglycinColon-3.060.022
50ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Colon-3.060.043
51SRPX2sushi-repeat containing protein, X-linked 2Colon+3.050.002
52NEUROD1neuronal differentiation 1Colon-3.050.034
53NLRP11NLR family, pyrin domain containing 11Colon+3.030.001
54MSLNmesothelinColon+3.030.025
55MROH9maestro heat-like repeat family member 9Colon-3.020.014
56BPIFCBPI fold containing family CColon-3.010.000
57WDR78WD repeat domain 78Colon-3.000.015
58CRYBA2crystallin, beta A2Colon-3.000.038
59A2ML1alpha-2-macroglobulin-like 1Colon-2.990.021
60PLP1proteolipid protein 1Colon-2.980.002
61LRRC8Eleucine rich repeat containing 8 family, member EColon+2.980.001
62DUSP21dual specificity phosphatase 21Colon-2.970.005
63FUT7fucosyltransferase 7 (alpha (1,3) fucosyltransferase)Blood+2.960.001
64SP5Sp5 transcription factorColon+2.950.046
65THBDthrombomodulinColon+2.930.003
66KRT78keratin 78Colon-2.930.002
67PTP4A3protein tyrosine phosphatase type IVA, member 3Colon+2.920.005
68FAPfibroblast activation protein, alphaColon+2.910.030
69HDAC9histone deacetylase 9Colon+2.910.007
70PROK2prokineticin 2Colon+2.900.032
71EPYCepiphycanColon-2.900.029
72GABRPgamma-aminobutyric acid (GABA) A receptor, piColon+2.900.045
73PABPC1Lpoly(A) binding protein, cytoplasmic 1-likeColon+2.890.022
74LGI4leucine-rich repeat LGI family, member 4Colon-2.890.007
75FADS1fatty acid desaturase 1Colon+2.880.006
76SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1Colon+2.880.022
77MMP1matrix metallopeptidase 1 (interstitial collagenase)Colon+2.870.034
78FCRLAFc receptor-like AColon-2.870.035
79CASD1CAS1 domain containing 1Colon-2.860.022
80MYOTmyotilinColon-2.850.021
81PSPHphosphoserine phosphataseColon+2.840.028
82SLFN5schlafen family member 5Colon+2.840.025
83CRHBPcorticotropin releasing hormone binding proteinColon-2.840.019
84SV2Csynaptic vesicle glycoprotein 2CColon-2.830.013
85TGFB2transforming growth factor, beta 2Colon+2.830.015
86GPATCH2G patch domain containing 2Colon-2.810.043
87LOXL4lysyl oxidase-like 4Colon-2.810.017
88ADAMTS20ADAM metallopeptidase with thrombospondin type 1 motif, 20Colon-2.810.033
89FAM151Afamily with sequence similarity 151, member AColon-2.790.004
90HBEGFheparin-binding EGF-like growth factorColon+2.790.032
91IGHA1immunoglobulin heavy constant alpha 1Colon-2.790.038
92KDELR3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3Colon+2.780.006
93UNC5Cunc-5 homolog C (C. elegans)Colon-2.780.016
94S100A8S100 calcium binding protein A8Colon+2.760.048
95STRIP2striatin interacting protein 2Colon+2.750.009
96SH3TC2SH3 domain and tetratricopeptide repeats 2Colon+2.750.003
97CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Colon+2.740.037
98ZNF446zinc finger protein 446Colon+2.740.006
99PDPNpodoplaninColon+2.740.020
100BAALCbrain and acute leukemia, cytoplasmicColon-2.740.034
101AQP9aquaporin 9Colon+2.730.041
102CXCL3chemokine (C-X-C motif) ligand 3Colon+2.730.028
103NPAS3neuronal PAS domain protein 3Colon-2.730.031
104CEP72centrosomal protein 72kDaColon+2.720.048
105SPATA45spermatogenesis associated 45Colon+2.720.005
106IGFBP5insulin-like growth factor binding protein 5Colon+2.710.003
107FABP4fatty acid binding protein 4, adipocyteColon-2.710.012
108DBNDD1dysbindin (dystrobrevin binding protein 1) domain containing 1Colon+2.710.004
109COL20A1collagen, type XX, alpha 1Colon-2.700.023
110TRIM29tripartite motif containing 29Colon+2.700.038
111LHX9LIM homeobox 9Colon-2.690.030
112GALgalanin/GMAP prepropeptideColon+2.680.037
113LAMP1lysosomal-associated membrane protein 1Blood+2.680.004
114IL20RAinterleukin 20 receptor, alphaColon+2.680.043
115CEP41centrosomal protein 41kDaColon+2.680.009
116KLHL22kelch-like family member 22Blood+2.660.002
117DNM3dynamin 3Colon+2.650.004
118BICD1bicaudal D homolog 1 (Drosophila)Colon+2.650.041
119DYX1C1dyslexia susceptibility 1 candidate 1Colon+2.650.006
120LINC00320long intergenic non-protein coding RNA 320Colon-2.640.025
121SNRKSNF related kinaseColon+2.640.016
122FABP2fatty acid binding protein 2, intestinalColon-2.640.019
123SPAG6sperm associated antigen 6Colon-2.640.035
124SLC4A4solute carrier family 4 (sodium bicarbonate cotransporter), member 4Colon-2.640.040
125NSFL1CNSFL1 (p97) cofactor (p47)Colon-2.640.004
126GATA4GATA binding protein 4Colon-2.630.028
127APLNapelinColon+2.630.002
128SPP1secreted phosphoprotein 1Colon+2.630.020
129ASPAaspartoacylaseColon-2.630.034
130M1APmeiosis 1 associated proteinColon-2.620.007
131SYNE1spectrin repeat containing, nuclear envelope 1Colon-2.620.027
132ABCG2ATP-binding cassette, sub-family G (WHITE), member 2Colon-2.620.037
133CXCL12chemokine (C-X-C motif) ligand 12Colon-2.610.017
134ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2Colon+2.600.016
135TRPM6transient receptor potential cation channel, subfamily M, member 6Colon-2.600.019
136STARD13StAR-related lipid transfer (START) domain containing 13Colon+2.600.014
137GPRC5DG protein-coupled receptor, class C, group 5, member DColon-2.600.046
138CYB5RLcytochrome b5 reductase-likeColon-2.590.006
139TMEM87Atransmembrane protein 87AColon+2.590.027
140NKAIN2Na+/K+ transporting ATPase interacting 2Colon-2.590.030
141PTGER3prostaglandin E receptor 3 (subtype EP3)Colon-2.590.035
142PLNphospholambanColon+2.580.044
143DNM1dynamin 1Colon+2.580.003
144KLHDC7Akelch domain containing 7AColon-2.570.029
145CLCN4chloride channel, voltage-sensitive 4Colon+2.570.014
146TSPAN7tetraspanin 7Colon-2.570.019
147CCDC38coiled-coil domain containing 38Colon+2.570.013
148PSMB7proteasome (prosome, macropain) subunit, beta type, 7Colon+2.560.026
149ZSWIM8zinc finger, SWIM-type containing 8Colon-2.560.004
150MAATS1MYCBP-associated, testis expressed 1Colon+2.560.035
151LINC01133long intergenic non-protein coding RNA 1133Colon+2.560.009
152BICD2bicaudal D homolog 2 (Drosophila)Colon-2.560.048
153RP3-510O8.4uncharacterized LOC285847Colon+2.560.022
154MIATmyocardial infarction associated transcript (non-protein coding)Blood+2.560.006
155STATHstatherinColon-2.560.020
156PDXDC1pyridoxal-dependent decarboxylase domain containing 1Blood-2.560.004
157ENHOenergy homeostasis associatedColon-2.560.038
158CRHR1corticotropin releasing hormone receptor 1Colon-2.550.018
159ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Colon-2.550.042
160PAX8paired box 8Colon-2.550.043
161SULT1C2sulfotransferase family, cytosolic, 1C, member 2Colon+2.540.016
162DKFZp451B082uncharacterized LOC401282Colon+2.540.007
163GPR132G protein-coupled receptor 132Blood+2.530.002
164ADAM12ADAM metallopeptidase domain 12Colon+2.530.021
165RASAL2RAS protein activator like 2Colon+2.520.031
166LINC00883long intergenic non-protein coding RNA 883Colon+2.520.017
167FJX1four jointed box 1 (Drosophila)Colon+2.520.016
168ZDHHC11zinc finger, DHHC-type containing 11Colon+2.510.014
169IL1R2interleukin 1 receptor, type IIColon-2.510.023
170NFIXnuclear factor I/X (CCAAT-binding transcription factor)Colon+2.510.011
171MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)Blood+2.510.011
172ATP11CATPase, class VI, type 11CColon+2.510.022
173SLC9A9solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9Colon-2.510.009
174OSR2odd-skipped related transciption factor 2Colon+2.500.028
175PLEKHA8pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8Colon+2.500.014
176LOC100131170uncharacterized LOC100131170Blood+2.480.003
177PLA1Aphospholipase A1 member AColon+2.480.018
178GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2AColon-2.470.045
179CCDC150coiled-coil domain containing 150Colon+2.470.012
180CLEC12BC-type lectin domain family 12, member BColon-2.470.046
181MOB3AMOB kinase activator 3AColon-2.460.010
182PLEKHG2pleckstrin homology domain containing, family G (with RhoGef domain) member 2Colon+2.460.039
183MCOLN1mucolipin 1Blood+2.450.010
184ZDHHC2zinc finger, DHHC-type containing 2Colon+2.450.030
185TFDP3transcription factor Dp family, member 3Colon-2.450.043
186RORBRAR-related orphan receptor BColon-2.450.021
187GJA5gap junction protein, alpha 5, 40kDaColon+2.440.009
188PLCZ1phospholipase C, zeta 1Colon-2.440.044
189FBLN2fibulin 2Colon-2.430.016
190COG2component of oligomeric golgi complex 2Colon+2.420.015
191SLC16A4solute carrier family 16, member 4Colon+2.420.016
192AKAP10A kinase (PRKA) anchor protein 10Colon+2.420.007
193MAGI1membrane associated guanylate kinase, WW and PDZ domain containing 1Blood-2.420.017
194ADAM22ADAM metallopeptidase domain 22Colon+2.410.032
195MICAL2microtubule associated monooxygenase, calponin and LIM domain containing 2Colon-2.410.035
196ZMIZ1zinc finger, MIZ-type containing 1Colon-2.400.016
197SORCS2sortilin-related VPS10 domain containing receptor 2Colon+2.400.004
198ANKS6ankyrin repeat and sterile alpha motif domain containing 6Colon+2.400.033
199STAT5Bsignal transducer and activator of transcription 5BColon+2.400.027
200ADAMDEC1ADAM-like, decysin 1Colon-2.390.010
201GAS1growth arrest-specific 1Colon+2.380.048
202EMC8ER membrane protein complex subunit 8Blood+2.380.004
203HELLShelicase, lymphoid-specificBlood+2.380.006
204FKBP10FK506 binding protein 10, 65 kDaColon+2.380.022
205GALNT6polypeptide N-acetylgalactosaminyltransferase 6Colon+2.380.024
206FAM153Afamily with sequence similarity 153, member AColon-2.370.041
207C9orf62chromosome 9 open reading frame 62Colon+2.370.009
208KIAA1549KIAA1549Blood-2.370.002
209SOX10SRY (sex determining region Y)-box 10Colon-2.360.024
210NRXN1neurexin 1Colon-2.360.043
211RAB12RAB12, member RAS oncogene familyColon+2.350.025
212ZNF44zinc finger protein 44Colon-2.350.032
213SPAM1sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)Colon-2.350.040
214AFF4AF4/FMR2 family, member 4Colon-2.350.031
215GDF11growth differentiation factor 11Colon+2.350.020
216EPPINepididymal peptidase inhibitorBlood-2.350.006
217CMIPc-Maf inducing proteinColon+2.350.029
218ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9Colon+2.340.010
219MROH1maestro heat-like repeat family member 1Colon+2.340.002
220TBX2T-box 2Colon-2.330.045
221LALBAlactalbumin, alpha-Colon-2.330.040
222ETNK1ethanolamine kinase 1Colon+2.330.034
223HBZhemoglobin, zetaColon-2.330.019
224SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5Colon+2.330.025
225ZFR2zinc finger RNA binding protein 2Colon-2.320.028
226ADCK5aarF domain containing kinase 5Colon+2.320.013
227FOXP3forkhead box P3Colon+2.320.022
228TAGAPT-cell activation RhoGTPase activating proteinColon+2.310.038
229IFNB1interferon, beta 1, fibroblastColon-2.310.031
230TRMT2BtRNA methyltransferase 2 homolog B (S. cerevisiae)Colon+2.310.001
231EPHA7EPH receptor A7Colon-2.300.049
232CLPBClpB caseinolytic peptidase B homolog (E. coli)Colon+2.300.029
233TDP1tyrosyl-DNA phosphodiesterase 1Colon-2.300.021
234RGS7regulator of G-protein signaling 7Blood-2.300.014
235ERGIC3ERGIC and golgi 3Colon-2.300.026
236GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeColon+2.300.005
237TMEFF2transmembrane protein with EGF-like and two follistatin-like domains 2Colon+2.300.014
238TIMP1TIMP metallopeptidase inhibitor 1Colon+2.290.001
239COL1A2collagen, type I, alpha 2Colon+2.290.003
240PARVAparvin, alphaBlood-2.290.009
241HSPA12Bheat shock 70kD protein 12BColon+2.280.035
242FBXW2F-box and WD repeat domain containing 2Colon-2.280.011
243ABHD11abhydrolase domain containing 11Blood+2.280.014
244STC1stanniocalcin 1Colon+2.280.027
245FSCN1fascin actin-bundling protein 1Colon+2.270.018
246RMDN2regulator of microtubule dynamics 2Colon-2.270.038
247SPTBN2spectrin, beta, non-erythrocytic 2Colon+2.260.006
248HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1Colon-2.250.047
249FAM20Afamily with sequence similarity 20, member ABlood+2.250.033
250FAM219Afamily with sequence similarity 219, member AColon+2.250.037
251CDH6cadherin 6, type 2, K-cadherin (fetal kidney)Colon+2.250.048
252PCNXL4pecanex-like 4 (Drosophila)Blood-2.250.010
253YPEL4yippee-like 4 (Drosophila)Colon-2.240.007
254PDLIM5PDZ and LIM domain 5Colon+2.240.025
255MAP4K2mitogen-activated protein kinase kinase kinase kinase 2Colon+2.240.003
256PCDH11Yprotocadherin 11 Y-linkedBlood-2.230.021
257NPYneuropeptide YColon-2.230.002
258SOX1SRY (sex determining region Y)-box 1Blood-2.230.003
259SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Colon+2.230.041
260LOXL1lysyl oxidase-like 1Blood+2.220.012
261AMPD1adenosine monophosphate deaminase 1Colon-2.220.044
262SLC19A1solute carrier family 19 (folate transporter), member 1Colon+2.220.018
263SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 2Blood-2.220.003
264NAALAD2N-acetylated alpha-linked acidic dipeptidase 2Colon-2.220.037
265SND1-IT1SND1 intronic transcript 1 (non-protein coding)Colon+2.220.017
266TMEM158transmembrane protein 158 (gene/pseudogene)Colon+2.210.017
267CGREF1cell growth regulator with EF-hand domain 1Colon+2.200.037
268CD70CD70 moleculeColon+2.200.037
269GPM6Bglycoprotein M6BColon-2.200.002
270LINC01138long intergenic non-protein coding RNA 1138Colon-2.200.048
271MAGEE2melanoma antigen family E, 2Blood-2.190.021
272CXorf36chromosome X open reading frame 36Colon+2.180.040
273PAFAH1B2platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)Colon-2.180.049
274METmet proto-oncogeneColon+2.180.019
275PPP2R3Bprotein phosphatase 2, regulatory subunit B'', betaColon+2.180.009
276RTEL1regulator of telomere elongation helicase 1Colon+2.180.033
277FLJ37453uncharacterized LOC729614Blood+2.180.002
278NPPBnatriuretic peptide BColon+2.180.045
279LOC157503uncharacterized LOC157503Colon-2.170.043
280RARBretinoic acid receptor, betaBlood-2.170.011
281RENBPrenin binding proteinBlood+2.170.001
282TNFSF15tumor necrosis factor (ligand) superfamily, member 15Colon+2.160.043
283MAPK11mitogen-activated protein kinase 11Colon-2.160.034
284ACAT1acetyl-CoA acetyltransferase 1Colon+2.160.009
285CUEDC1CUE domain containing 1Blood+2.160.008
286CACUL1CDK2-associated, cullin domain 1Blood+2.160.008
287LOC728061hCG2003663Colon+2.160.039
288GABREgamma-aminobutyric acid (GABA) A receptor, epsilonColon+2.160.023
289TMEM38Atransmembrane protein 38ABlood+2.160.007
290PRXperiaxinBlood+2.150.001
291CECR2cat eye syndrome chromosome region, candidate 2Colon-2.150.029
292PARM1prostate androgen-regulated mucin-like protein 1Blood-2.150.013
293ABCG8ATP-binding cassette, sub-family G (WHITE), member 8Colon-2.150.043
294MCFD2multiple coagulation factor deficiency 2Colon+2.150.018
295TIGD4tigger transposable element derived 4Blood-2.140.003
296LAMA5laminin, alpha 5Colon+2.140.035
297DUSP7dual specificity phosphatase 7Colon-2.130.039
298ESM1endothelial cell-specific molecule 1Colon+2.130.047
299IGHV5-78immunoglobulin heavy variable 5-78 (pseudogene)Blood-2.130.020
300BCLAF1BCL2-associated transcription factor 1Colon+2.120.021
301IL1Binterleukin 1, betaColon+2.120.004
302ELP6elongator acetyltransferase complex subunit 6Colon+2.120.043
303NRG1neuregulin 1Blood+2.110.002
304CAPScalcyphosineBlood+2.110.015
305CD226CD226 moleculeColon-2.100.049
306GPR56G protein-coupled receptor 56Colon+2.100.028
307SEC14L2SEC14-like 2 (S. cerevisiae)Colon+2.100.032
308CNN3calponin 3, acidicBlood-2.090.023
309CD300ACD300a moleculeBlood-2.090.007
310IL1RNinterleukin 1 receptor antagonistColon+2.080.048
311ABRAactin-binding Rho activating proteinBlood-2.080.048
312ZNF549zinc finger protein 549Blood-2.080.026
313PTNpleiotrophinColon-2.080.045
314APOL4apolipoprotein L, 4Colon-2.080.038
315MTRF1Lmitochondrial translational release factor 1-likeColon+2.070.005
316PLXNB2plexin B2Colon-2.070.037
317CHRNA10cholinergic receptor, nicotinic, alpha 10 (neuronal)Colon-2.070.042
318VWDEvon Willebrand factor D and EGF domainsBlood+2.070.031
319OR6A2olfactory receptor, family 6, subfamily A, member 2Blood-2.050.016
320ADAM15ADAM metallopeptidase domain 15Blood+2.050.024
321LUZP2leucine zipper protein 2Colon-2.050.034
322DUSP26dual specificity phosphatase 26 (putative)Colon-2.050.017
323KIF6kinesin family member 6Colon-2.050.040
324DRP2dystrophin related protein 2Blood-2.050.036
325SPRY4sprouty homolog 4 (Drosophila)Blood-2.040.012
326ART3ADP-ribosyltransferase 3Colon+2.040.042
327CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1Blood-2.040.017
328SFT2D1SFT2 domain containing 1Colon+2.040.048
329GPM6Aglycoprotein M6ABlood-2.040.044
330IFT122intraflagellar transport 122 homolog (Chlamydomonas)Blood+2.030.004
331UGT8UDP glycosyltransferase 8Blood-2.030.019
332LORloricrinColon-2.030.027
333RP11-307C19.3uncharacterized LOC253044Colon-2.030.039
334PKNOX2PBX/knotted 1 homeobox 2Blood-2.030.018
335CDCP1CUB domain containing protein 1Colon+2.030.002
336GPX8glutathione peroxidase 8 (putative)Colon+2.030.034
337MCAMmelanoma cell adhesion moleculeColon+2.020.006
338CDC25Acell division cycle 25AColon+2.020.040
339BIKBCL2-interacting killer (apoptosis-inducing)Blood+2.020.007
340RPL32P3ribosomal protein L32 pseudogene 3Colon+2.020.040
341TM4SF18transmembrane 4 L six family member 18Blood-2.020.023
342SIK3SIK family kinase 3Colon+2.020.032
343ZPBPzona pellucida binding proteinBlood-2.010.013
344FAM150Bfamily with sequence similarity 150, member BBlood-2.010.024
345AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2Blood+2.010.026
346COL4A1collagen, type IV, alpha 1Colon+2.000.012
347MARCOmacrophage receptor with collagenous structureBlood+2.000.014
348MUM1melanoma associated antigen (mutated) 1Blood+2.000.027
349CAB39Lcalcium binding protein 39-likeColon+2.000.020
350F13A1coagulation factor XIII, A1 polypeptideColon-1.990.042
351DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22Blood-1.990.018
352ZNF79zinc finger protein 79Blood-1.980.018
353EFCAB1EF-hand calcium binding domain 1Colon-1.980.043
354ZDHHC9zinc finger, DHHC-type containing 9Blood+1.980.011
355NRROSnegative regulator of reactive oxygen speciesBlood+1.980.010
356NAT16N-acetyltransferase 16 (GCN5-related, putative)Colon-1.970.042
357LOC57399uncharacterized gastric protein ZA52PBlood-1.970.016
358HOXC8homeobox C8Colon-1.970.032
359AHDC1AT hook, DNA binding motif, containing 1Colon+1.970.024
360NEK1NIMA-related kinase 1Blood+1.960.023
361FGF11fibroblast growth factor 11Colon-1.960.046
362COL1A1collagen, type I, alpha 1Colon+1.960.020
363PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1Colon+1.960.041
364TJP2tight junction protein 2Blood-1.960.026
365HIF3Ahypoxia inducible factor 3, alpha subunitBlood-1.960.013
366B3GAT2beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)Blood-1.950.038
367GAS6growth arrest-specific 6Blood+1.950.007
368TRPV6transient receptor potential cation channel, subfamily V, member 6Colon-1.950.013
369LRRN3leucine rich repeat neuronal 3Blood-1.950.034
370LCATlecithin-cholesterol acyltransferaseBlood+1.950.011
371E2F7E2F transcription factor 7Blood-1.940.017
372FMO2flavin containing monooxygenase 2 (non-functional)Blood-1.940.036
373PDZD2PDZ domain containing 2Blood-1.940.045
374SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DBlood-1.940.029
375SAC3D1SAC3 domain containing 1Blood+1.930.014
376PTPRKprotein tyrosine phosphatase, receptor type, KBlood-1.930.022
377BAHCC1BAH domain and coiled-coil containing 1Blood+1.930.010
378ALPLalkaline phosphatase, liver/bone/kidneyColon-1.930.016
379PPP2R3Bprotein phosphatase 2, regulatory subunit B'', betaBlood+1.930.034
380LOC100505711uncharacterized LOC100505711Blood-1.930.014
381RGS1regulator of G-protein signaling 1Blood-1.930.028
382OLFML2Bolfactomedin-like 2BColon+1.930.015
383MCF2LMCF.2 cell line derived transforming sequence-likeBlood-1.920.023
384HEMK1HemK methyltransferase family member 1Blood+1.920.015
385SLC6A6solute carrier family 6 (neurotransmitter transporter), member 6Blood+1.920.019
386NSUN7NOP2/Sun domain family, member 7Colon+1.920.033
387KIRRELkin of IRRE like (Drosophila)Colon+1.920.015
388TCEA1transcription elongation factor A (SII), 1Colon+1.920.029
389MOSv-mos Moloney murine sarcoma viral oncogene homologBlood-1.920.047
390KANK1KN motif and ankyrin repeat domains 1Colon+1.920.031
391TGFBRAP1transforming growth factor, beta receptor associated protein 1Colon+1.910.047
392KCTD17potassium channel tetramerization domain containing 17Blood-1.910.014
393TAOK1TAO kinase 1Colon+1.910.017
394GTSF1Lgametocyte specific factor 1-likeBlood-1.910.035
395AP3D1adaptor-related protein complex 3, delta 1 subunitBlood+1.910.037
396ENDOD1endonuclease domain containing 1Colon-1.910.007
397CDK5RAP2CDK5 regulatory subunit associated protein 2Colon+1.900.005
398IGLV4-60immunoglobulin lambda variable 4-60Colon-1.890.042
399COL6A3collagen, type VI, alpha 3Colon+1.890.008
400CLLU1chronic lymphocytic leukemia up-regulated 1Blood-1.890.013
401TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Blood+1.890.011
402NFATC4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4Blood-1.880.020
403VGLL1vestigial-like family member 1Colon-1.880.049
404ADORA3adenosine A3 receptorColon-1.880.010
405TLE6transducin-like enhancer of split 6Colon-1.870.037
406MVB12Bmultivesicular body subunit 12BBlood-1.870.025
407SRGAP2SLIT-ROBO Rho GTPase activating protein 2Blood+1.870.023
408MAPK8IP3mitogen-activated protein kinase 8 interacting protein 3Blood+1.870.014
409SPPL2Bsignal peptide peptidase like 2BBlood+1.870.036
410H2AFYH2A histone family, member YBlood-1.870.030
411NUP50nucleoporin 50kDaBlood+1.870.031
412MAP4K4mitogen-activated protein kinase kinase kinase kinase 4Colon+1.860.040
413ITGA7integrin, alpha 7Colon+1.860.027
414SYT12synaptotagmin XIIColon-1.860.050
415RNF207ring finger protein 207Blood-1.860.015
416PRYPTPN13-like, Y-linkedBlood-1.860.034
417G6PCglucose-6-phosphatase, catalytic subunitBlood-1.850.034
418DEFB124defensin, beta 124Blood-1.850.045
419SLC16A3solute carrier family 16 (monocarboxylate transporter), member 3Blood+1.850.018
420MARVELD1MARVEL domain containing 1Blood-1.850.042
421CFBcomplement factor BColon+1.840.014
422VWFvon Willebrand factorColon+1.840.027
423SOX4SRY (sex determining region Y)-box 4Blood-1.840.048
424BDH13-hydroxybutyrate dehydrogenase, type 1Colon-1.830.019
425MFAP4microfibrillar-associated protein 4Colon-1.830.047
426LINC00173long intergenic non-protein coding RNA 173Blood+1.830.010
427TPM2tropomyosin 2 (beta)Colon+1.830.023
428DAAM1dishevelled associated activator of morphogenesis 1Blood+1.830.027
429H1FOOH1 histone family, member O, oocyte-specificColon-1.830.039
430SZT2seizure threshold 2 homolog (mouse)Colon-1.820.019
431CR2complement component (3d/Epstein Barr virus) receptor 2Blood-1.820.017
432CORO2Bcoronin, actin binding protein, 2BBlood-1.820.037
433DKFZP434K028uncharacterized LOC26070Blood-1.820.024
434NASPnuclear autoantigenic sperm protein (histone-binding)Blood+1.820.050
435THAP10THAP domain containing 10Blood-1.810.049
436ACANaggrecanBlood-1.810.034
437RIBC1RIB43A domain with coiled-coils 1Colon+1.810.046
438TNRC18trinucleotide repeat containing 18Blood+1.800.012
439ZBTB8Bzinc finger and BTB domain containing 8BBlood-1.800.019
440C20orf62chromosome 20 open reading frame 62Blood-1.790.031
441MEGF10multiple EGF-like-domains 10Blood-1.790.040
442MAP3K11mitogen-activated protein kinase kinase kinase 11Colon-1.790.048
443LOC339240keratin 17 pseudogeneBlood-1.790.042
444PTCH1patched 1Blood-1.780.029
445C9orf62chromosome 9 open reading frame 62Blood-1.780.035
446LDHClactate dehydrogenase CBlood-1.780.038
447DCNdecorinBlood-1.780.048
448CA14carbonic anhydrase XIVBlood-1.780.030
449EHD4EH-domain containing 4Blood+1.780.047
450CD48CD48 moleculeBlood+1.770.030
451KIAA0319LKIAA0319-likeBlood+1.770.036
452HCFC1R1host cell factor C1 regulator 1 (XPO1 dependent)Blood+1.770.017
453ARandrogen receptorBlood-1.760.049
454TPPP3tubulin polymerization-promoting protein family member 3Blood+1.760.041
455IER5Limmediate early response 5-likeBlood+1.760.004
456HCFC1host cell factor C1 (VP16-accessory protein)Blood-1.760.041
457SCAMP4secretory carrier membrane protein 4Blood+1.760.047
458LINC00937long intergenic non-protein coding RNA 937Blood+1.740.027
459FGAfibrinogen alpha chainBlood-1.740.027
460SMOXspermine oxidaseBlood+1.740.010
461NMT1N-myristoyltransferase 1Blood+1.730.046
462C21orf49chromosome 21 open reading frame 49Blood-1.730.041
463IL8interleukin 8Blood-1.730.037
464ANTXR1anthrax toxin receptor 1Colon-1.730.022
465LILRB5leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5Blood-1.730.018
466MYL9myosin, light chain 9, regulatoryBlood+1.720.049
467LYPD4LY6/PLAUR domain containing 4Blood-1.720.041
468CYTH2cytohesin 2Blood+1.710.050
469CDCA5cell division cycle associated 5Blood+1.710.022
470CECR7cat eye syndrome chromosome region, candidate 7 (non-protein coding)Blood-1.700.040
471ZNF684zinc finger protein 684Colon-1.700.045
472TP63tumor protein p63Blood-1.690.044
473PGLYRP1peptidoglycan recognition protein 1Blood+1.690.042
474MSRB3methionine sulfoxide reductase B3Blood-1.690.025
475CD36CD36 molecule (thrombospondin receptor)Blood+1.690.036
476ZBTB7Bzinc finger and BTB domain containing 7BBlood+1.680.049
477TMEM182transmembrane protein 182Blood-1.680.038
478ZNF527zinc finger protein 527Blood-1.670.040
479LDLRlow density lipoprotein receptorBlood+1.660.043
480KAZNkazrin, periplakin interacting proteinBlood+1.660.043
481QKIQKI, KH domain containing, RNA bindingBlood+1.650.049
482CD200CD200 moleculeBlood-1.650.042
483CARS2cysteinyl-tRNA synthetase 2, mitochondrial (putative)Blood+1.650.045
484RNF25ring finger protein 25Blood+1.640.040
485CELF2CUGBP, Elav-like family member 2Blood+1.640.014
486MIPEPmitochondrial intermediate peptidaseBlood-1.630.041
487KIAA1211KIAA1211Blood-1.620.041
488ROCK1Rho-associated, coiled-coil containing protein kinase 1Blood+1.620.049
489ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3Blood+1.610.034
490FASTKFas-activated serine/threonine kinaseBlood+1.600.021
491CEP104centrosomal protein 104kDaBlood+1.600.033
492PPP1R13Lprotein phosphatase 1, regulatory subunit 13 likeBlood-1.580.042
493SLC38A10solute carrier family 38, member 10Blood+1.550.043
494LRP1low density lipoprotein receptor-related protein 1Blood+1.550.047
495TPP1tripeptidyl peptidase IBlood+1.520.042
496ZNF92zinc finger protein 92Blood-1.520.047
497PLXND1plexin D1Blood+1.520.035
498PM20D2peptidase M20 domain containing 2Blood-1.510.035
499SQLEsqualene epoxidaseBlood+1.500.044
500SLC30A5solute carrier family 30 (zinc transporter), member 5Blood-1.490.030
501DENND5BDENN/MADD domain containing 5BBlood-1.440.045
502RRASrelated RAS viral (r-ras) oncogene homologBlood+1.410.039

Expression patterns in normal tissues for genes affiliated with Colorectal Cancer

Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

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Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0CCND1, BRAF, DCC, TP53, CTNNB1, TLR4
210.9PIK3CA, TLR4, CTNNB1, CCND1, BRAF, TP53
3
Show member pathways
10.9GALNT12, PLA2G2A, MT-CO2, MT-CYB, MT-ND4L, MT-CO1
4
Show member pathways
Signal transduction PTEN pathway59
10.9BRAF, CTNNB1, CCND1, MSH6, DCC, TP53
510.9CCND1, CTNNB1, PIK3CA, MSH6, BRAF, DCC
6
Show member pathways
10.8MT-CO2, MT-ND4L, PIK3CA, MT-CO1, TP53, MT-CYB
7
Show member pathways
Signaling Pathways in Glioblastoma37
10.8BRAF, CCND1, PIK3CA, TP53, MSH6, CTNNB1
8
Show member pathways
10.8TLR2, TP53, TLR4, BRAF, CCND1
910.8TP53, CCND1, TLR4, PIK3CA, TLR2
10
Show member pathways
10.8PIK3CA, TLR4, TLR2, CCND1, TP53
11
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.8PIK3CA, TLR2, TP53, CCND1, TLR4
12
Show member pathways
10.8BRAF, PIK3CA, TLR2, TLR4, TP53
1310.8PIK3CA, TP53, CTNNB1, CCND1, DCC
1410.8CCND1, CTNNB1, TP53, BRAF, MSH6
1510.7PLA2G2A, TP53, TLR4, CCND1
1610.7TP53, BRAF, CCND1, CTNNB1
1710.7CTNNB1, TP53, CCND1, BRAF
18
Show member pathways
Alzheimers Disease37
10.7MT-CO2, TP53, MT-CYB, MT-CO1
19
Show member pathways
10.7BRAF, PIK3CA, TP53, CCND1
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.7BRAF, TP53, PIK3CA, CCND1
2110.7TP53, CTNNB1, CCND1, PIK3CA
2210.7CCND1, CTNNB1, TP53, PIK3CA
23
Show member pathways
10.7PIK3CA, CCND1, PLA2G2A, BRAF
24
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.7TP53, PIK3CA, CCND1, MSH6
25
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
10.7PIK3CA, CCND1, BRAF, CTNNB1
26
Show member pathways
10.7CTNNB1, PIK3CA, PLA2G2A, BRAF
27
Show member pathways
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
10.7CCND1, TP53, PIK3CA
2810.7CCND1, TP53, PIK3CA
29
Show member pathways
10.7TLR4, TLR2, BRAF
30
Show member pathways
10.7TLR4, PIK3CA, TP53
3110.7TLR4, TLR2, PIK3CA
3210.7CCND1, MT-CO2, CTNNB1
3310.7MSH6, CCND1, TP53
3410.7MT-CO1, MT-CYB, MT-CO2
3510.7BRAF, PIK3CA, CCND1
36
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.7BRAF, CCND1, PIK3CA
3710.7BRAF, TLR4, CTNNB1
38
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion59
Pathogenic Escherichia coli infection37
10.7BRAF, CTNNB1, TLR4
3910.7PIK3CA, BRAF, TP53
40
Show member pathways
10.7BRAF, TP53, PIK3CA
41
Show member pathways
Development A1 receptor signaling59
G protein signaling G Protein alpha q signaling cascades59
10.7PIK3CA, CTNNB1, CCND1
42
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
10.7CTNNB1, PIK3CA, CCND1
4310.7CTNNB1, CCND1, PIK3CA
4410.7CTNNB1, PLA2G2A, PIK3CA
45
Show member pathways
Development A2B receptor action via G protein alpha s59
10.7PIK3CA, CTNNB1, BRAF
46
Show member pathways
RAC1 signaling pathway37
10.7PIK3CA, CTNNB1, BRAF
47
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
10.7PIK3CA, BRAF, CTNNB1
48
Show member pathways
10.6DCC, CTNNB1, PIK3CA
49
Show member pathways
10.6MLH3, MSH6, PMS2
5010.6PIK3CA, BRAF

Compounds for genes affiliated with Colorectal Cancer

About this section

Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1serine4411.5CTNNB1, PLA2G2A, MT-CYB, CCND1, MSH6, TP53
2vegf4411.4PLA2G2A, CCND1, BRAF, TP53, TLR4, TLR2
3retinoic acid44 2512.4TLR2, BRAF, PIK3CA, TLR4, TP53, CCND1
4atp44 2912.4CTNNB1, TLR2, MT-CO2, MT-CYB, MT-CO1, BRAF
5ly2940024411.3TP53, BRAF, CCND1, PLA2G2A, CTNNB1, TLR4
6cycloheximide4411.3TLR2, TLR4, CTNNB1, MT-CYB, PLA2G2A, TP53
7crcs4411.3PIK3CA, PMS2, CTNNB1, CCND1, MSH6, BRAF
8cisplatin44 50 60 1214.3CTNNB1, PIK3CA, TLR4, CCND1, MSH6, BRAF
9h2o24411.3CTNNB1, PLA2G2A, PIK3CA, TLR2, MT-CYB, TLR4
10tyrosine4411.3PIK3CA, PDGFRL, TLR2, TLR4, BRAF, MSH6
11sb 20358044 6012.3CCND1, CTNNB1, TLR2, TLR4, TP53, BRAF
12paclitaxel44 50 1213.3CCND1, BRAF, TP53, CTNNB1, TLR4, PIK3CA
13wortmannin4411.3TLR4, CCND1, CTNNB1, TLR2, PIK3CA, BRAF
14paraffin4411.2PMS2, CCND1, MSH6, BRAF, TP53, CTNNB1
15n acetylcysteine4411.2CTNNB1, PLA2G2A, CCND1, TP53, TLR4
16phospholipid4411.2CTNNB1, PLA2G2A, MT-CYB, TLR4, TLR2
17histamine44 29 2513.2CTNNB1, PLA2G2A, TLR4, TLR2, PIK3CA
18pd 98,0594411.2PIK3CA, CTNNB1, TLR2, CCND1, BRAF
19pdtc4411.1TP53, PIK3CA, TLR4, PLA2G2A
20doxorubicin44 50 1213.1TP53, MSH6, CCND1, CTNNB1, PIK3CA
21actinomycin d4411.1TLR4, TP53, PLA2G2A, TLR2, PIK3CA
22adpribose4411.1TP53, PIK3CA, CTNNB1, CCND1
23geldanamycin44 50 60 1214.1CCND1, CTNNB1, BRAF, TP53
24palmitate4411.1PLA2G2A, TLR4, CTNNB1, TLR2
25phosphoinositide4411.1CTNNB1, CCND1, BRAF, TLR2, PIK3CA
26gf 109203x44 6012.1CCND1, TLR2, CTNNB1, PLA2G2A
27arginine4411.1PIK3CA, TP53, PLA2G2A, TLR2, CTNNB1, BRAF
28resveratrol44 60 25 1214.1CCND1, TP53, PIK3CA, CTNNB1
29genistein44 29 60 3 25 1216.1CCND1, TLR4, PIK3CA, CTNNB1, PLA2G2A
30phosphatidylinositol4411.1BRAF, TLR4, CTNNB1, PIK3CA, CCND1, TLR2
31egcg4411.1CCND1, TP53, PIK3CA, CTNNB1
32rofecoxib44 50 29 1214.1CTNNB1, MT-CO2, CCND1
33quercetin44 60 25 1214.0PIK3CA, CCND1, PLA2G2A, CTNNB1
34nadph44 2512.0PLA2G2A, MT-CYB, TLR4, TLR2, PIK3CA
35docosahexaenoic acid44 29 2513.0PLA2G2A, TLR2, TLR4
36o6-methylguanine4411.0MSH6, TP53, BRAF
37imatinib44 50 1213.0BRAF, CTNNB1, PIK3CA, CCND1
38cetuximab44 50 1213.0BRAF, CCND1, CTNNB1
39pge24411.0CTNNB1, TLR4, TLR2, MT-CO2, PLA2G2A
40threonine4410.9PIK3CA, CTNNB1, MSH6, BRAF, CCND1, MT-CYB
41arsenite44 2511.9PIK3CA, TP53, CCND1, CTNNB1
42arabinogalactan4410.9TLR2, TLR4
43indole-3-carbinol4410.9TP53, CCND1, CTNNB1
44sb-2167634410.9CCND1, CTNNB1
45fatty acid4410.8CTNNB1, MT-CO1, PLA2G2A, BRAF, TLR2
46alanine4410.8CTNNB1, TLR2, PLA2G2A, MT-CYB, TLR4, BRAF
47sulindac44 1211.8CCND1, TP53, CTNNB1
48depsipeptide4410.7CCND1, BRAF, TP53
49tacrolimus44 50 1212.6TLR2, CCND1, PIK3CA, TLR4
50superoxide44 2511.5PLA2G2A, MT-CYB, TLR4, TLR2, PIK3CA

GO Terms for genes affiliated with Colorectal Cancer

About this section

Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:03230010.6PMS2, MLH3

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of inflammatory responseGO:05072911.0TLR2, TLR4, PLA2G2A
2mismatch repairGO:00629811.0MSH6, PMS2, MLH3
3reciprocal meiotic recombinationGO:00713111.0MSH6, PMS2, MLH3
4cellular response to lipoteichoic acidGO:07122310.9TLR2, TLR4
5somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, PMS2
6positive regulation of macrophage cytokine productionGO:06090710.9TLR2, TLR4
7negative regulation of interleukin-17 productionGO:03270010.9TLR4, TLR2
8positive regulation of ERK1 and ERK2 cascadeGO:07037410.9BRAF, DCC, TLR4
9positive regulation of tumor necrosis factor biosynthetic processGO:04253510.9TLR2, TLR4
10mitotic G1 DNA damage checkpointGO:03157110.9TP53, CCND1
11positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.9TLR2, TLR4
12I-kappaB phosphorylationGO:00725210.9TLR2, TLR4
13somatic hypermutation of immunoglobulin genesGO:01644610.8PMS2, MSH6
14determination of adult lifespanGO:00834010.8TP53, MSH6
15positive regulation of chemokine productionGO:03272210.8TLR4, TLR2
16positive regulation of interleukin-10 productionGO:03273310.7TLR4, TLR2
17negative regulation of osteoclast differentiationGO:04567110.7TLR4, CTNNB1
18positive regulation of NF-kappaB import into nucleusGO:04234610.7TLR2, TLR4
19response to X-rayGO:01016510.6TP53, CCND1
20positive regulation of interferon-beta productionGO:03272810.6TLR4, TLR2
21positive regulation of interleukin-8 productionGO:03275710.5TLR4, TLR2
22ATP catabolic processGO:00620010.3MLH3, PMS2, MSH6

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0TLR4, TLR2, MLH3, PIK3CA, PMS2, TP53
2ATP bindingGO:00552410.8MSH6, BRAF, TP53, PMS2, MLH3, PIK3CA
3lipopolysaccharide receptor activityGO:00187510.8TLR4, TLR2
4chromatin bindingGO:00368210.8MLH3, TP53, MSH6, CTNNB1
5MutSalpha complex bindingGO:03240710.7PMS2, MLH3
6mismatched DNA bindingGO:03098310.7MSH6, MLH3
7transmembrane signaling receptor activityGO:00488810.7DCC, TLR4, TLR2
8ATPase activityGO:01688710.3MLH3, PMS2, MSH6

Products for genes affiliated with Colorectal Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Colorectal Cancer

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet