MCID: CLR023
MIFTS: 66

Colorectal Cancer malady

Cancer category

Summaries for Colorectal Cancer

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

MalaCards: Colorectal Cancer, also known as colorectal carcinoma, is related to adenoma and ulcerative colitis. An important gene associated with Colorectal Cancer is MCC (mutated in colorectal cancers), and among its related pathways are Colorectal Cancer Metastasis and Pathways in cancer. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia:64 Colorectal cancer, also known as colon cancer, rectal cancer, or bowel cancer, is a cancer from... more...

Description from OMIM:47 114500

Aliases & Classifications for Colorectal Cancer

Sources:
64Wikipedia, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

colorectal cancer 64 47 10 45 34 61
colorectal carcinoma 45 61


Related Diseases for Colorectal Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Colorectal Cancer family:

familial colorectal cancer colorectal cancer with chromosomal instability
colorectal cancer 6 colorectal cancer 2
colorectal cancer 1 colorectal cancer 5
colorectal cancer 7 colorectal cancer 12
colorectal cancer 8 colorectal cancer 4
colorectal cancer 9 colorectal cancer 3
colorectal cancer 10 colorectal cancer 11

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 314)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.5AXIN2, CTNNB1, PMS2, CCND1, BRAF, TLR4
2ulcerative colitis31.1TP53
3familial adenomatous polyposis31.0AXIN2, CCND1, PMS2, PMS1, PLA2G2A, MSH6
4adenocarcinoma30.9BAX, PLA2G2A, SMAD7, TP53, BRAF, CCND1
5muir-torre syndrome30.4MSH6
6stomach cancer30.4TP53
7squamous cell carcinoma30.3CTNNB1, SMAD7, TP53, BAX, PMS1, MT-CO1
8turcot syndrome30.3PMS2, MSH6
9thyroid cancer30.2CCND1, TP53, BRAF
10peutz-jeghers syndrome30.2PMS1, CTNNB1
11astrocytoma30.0PLA2G2A, TP53
12acute pancreatitis30.0TLR4, PLA2G2A
13hepatitis c29.9TLR4, TLR2
14familial colorectal cancer11.1
15vascular cancer11.0
16colorectal cancer 111.0
17n syndrome10.9
18colorectal cancer 210.8
19colorectal cancer, somatic10.8
20colorectal cancer 810.7
21oral cancer10.7
22hypoxia10.7
23colorectal cancer 310.7
24colorectal cancer 1110.7
25colorectal cancer 710.6
26colorectal cancer 1010.6
27colorectal cancer 610.5
28colorectal cancer 1210.5
29brain cancer10.5
30cancer progression/metastasis10.5
31colorectal cancer 510.5
32colorectal cancer 410.5
33peritoneal carcinoma10.5
34micro syndrome10.5
35colorectal cancer 910.4
36colorectal cancer, hereditary nonpolyposis, type 110.4
37bone marrow cancer10.4
38hyperplastic polyposis syndrome10.4
39sclerosing cholangitis10.4
40primary sclerosing cholangitis10.4
41small bowel adenocarcinoma10.4
42young syndrome10.3
43oligodontia-colorectal cancer syndrome10.3
44gastric cancer, somatic10.3
45breast cancer susceptibility10.3
46crohn's disease10.3
47thrombocytosis10.3
48h. pylori infection10.3
49ileus10.3
50atrophic gastritis10.2

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Clinical Features for Colorectal Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114500

Clinical synopsis from OMIM:

114500

Drugs & Therapeutics for Colorectal Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Colorectal Cancer

Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Search CenterWatch for Colorectal Cancer

Genetic Tests for Colorectal Cancer

Anatomical Context for Colorectal Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Colorectal Cancer:

33
Skin, Liver, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Placenta, Prostate, Testis, Cervix, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Temporal lobe, Fetal liver, Fetal lung, Appendix, Fetal thyroid, Pituitary, Testis germ

Animal Models for Colorectal Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Colorectal Cancer:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538413.9TLR2, TLR4, BRAF, CCND1, PMS2, CTNNB1
2MP:001076813.9TLR2, TLR4, BRAF, CCND1, PMS2, CTNNB1
3MP:000200613.7TP53, PMS1, PMS2, CCND1, BRAF, TLR4
4MP:000538713.4PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
5MP:000538613.0CCND1, BRAF, TLR4, TLR2, CTNNB1, PPARD
6MP:000538913.0CCND1, BRAF, TLR4, CTNNB1, PPARD, MLH3
7MP:000538112.9PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
8MP:000538512.7CCND1, BRAF, TLR4, TLR2, CTNNB1, MT-CO1
9MP:000536912.6BRAF, TLR4, TLR2, CTNNB1, MT-CO1, BAX
10MP:000537812.6CCND1, BRAF, TLR4, TLR2, CTNNB1, PPARD
11MP:000539112.6CCND1, BRAF, TLR4, CTNNB1, DCC, BAX
12MP:000539712.5PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
13MP:000537912.4PMS2, CCND1, TLR2, MLH3, BAX, AXIN2
14MP:001077112.4CCND1, TLR4, TLR2, CTNNB1, PPARD, SMAD7
15MP:000537612.4PMS2, TLR4, TLR2, PPARD, MT-CO1, MSH6
16MP:000537011.9TLR4, TLR2, CTNNB1, PPARD, TP53, BRAF
17MP:000538811.7CCND1, CTNNB1, BAX, TP53
18MP:000363111.4TLR4, DCC, BAX, AXIN2
19MP:000539011.3CCND1, BAX, AXIN2

Publications for Colorectal Cancer

Sources:
51PubMed
See all sources

Articles related to Colorectal Cancer:

(show top 50)    (show all 7755)
idTitleAuthorsYear
1
Overexpression of aminoacylase 1 is associated with colorectal cancer progression. (23317546)
2013
2
Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer. (24337768)
2013
3
Association between XRCC3 Thr241Met polymorphism and colorectal cancer risk. (23504553)
2013
4
CYP2E1 T7632A and 9-bp insertion polymorphisms and colorectal cancer risk: a meta-analysis based on 4,592 cases and 5,918 controls. (23636797)
2013
5
Laparoscopic cytoreductive surgery and early postoperative intraperitoneal chemotherapy for patients with colorectal cancer peritoneal carcinomatosis: initial results from a single center. (24368743)
2013
6
MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis. (24375248)
2013
7
Differential involvement of RalA and RalB in colorectal cancer. (22790202)
2012
8
Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer. (22593457)
2012
9
Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis. (23285162)
2012
10
C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancer. (22404718)
2012
11
Detection of hypermethylated vimentin in urine of patients with colorectal cancer. (22251609)
2012
12
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. (21645337)
2011
13
Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer. (20222950)
2010
14
Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM. (19945966)
2010
15
No breast cancer association for transforming growth factor-beta pathway colorectal cancer single nucleotide polymorphisms. (19505925)
2009
16
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (19638987)
2009
17
cIAP2 as a therapeutic target in colorectal cancer and other malignancies. (19793002)
2009
18
Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability. (20057968)
2009
19
Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases. (19240817)
2009
20
Two cases of advanced colorectal cancer with UGT1A1*28 homozygosity treated by FOLFIRI]. (19620808)
2009
21
Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers. (18612427)
2008
22
Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. (18413748)
2008
23
Previstage GCC test for staging patients with colorectal cancer. (18785805)
2008
24
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. (18804418)
2008
25
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. (18794900)
2008
26
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. (18339680)
2008
27
Fecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer. (17649802)
2007
28
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer. (17192711)
2007
29
CD40-mediated death and cytokine secretion in colorectal cancer: a potential target for inflammatory tumour cell killing. (17534894)
2007
30
The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer. (18070705)
2007
31
The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer. (16786143)
2006
32
Microsatellite instability and expression of mismatch repair genes in sporadic endometrial cancer coexisting with colorectal or breast cancer. (15583795)
2005
33
Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. (15655543)
2005
34
Increased plasma MMP-2 protein expression in lymph node-positive patients with colorectal cancer. (15592677)
2005
35
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. (15254745)
2004
36
Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis. (15060742)
2004
37
Localization of thymidine phosphorylase in advanced gastric and colorectal cancer. (15323351)
2004
38
Glycemic load, carbohydrate intake, and risk of colorectal cancer in women: a prospective cohort study. (12813175)
2003
39
Cyclooxygenase-2 inhibitors in colorectal cancer. (12802790)
2003
40
The relationship between circulating interleukin-6 and carcinoembryonic antigen in patients with colorectal cancer. (12926107)
2003
41
Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification. (12657164)
2003
42
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers. (11314036)
2001
43
Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. (11445004)
2001
44
Value of pedigree/clinical data, immunohistochemistry and microsatellite instability analyses in reducing the cost of determining hMLH1 and hMSH2 gene mutations in patients with colorectal cancer. (10741294)
2000
45
Is (18)F-fluorodeoxyglucose positron emission tomography in recurrent colorectal cancer a contribution to surgical decision making? (11036130)
2000
46
Tumor localization by tumor infiltrating lymphocytes labeled with indium-111 in patients with metastatic renal cell carcinoma, melanoma, and colorectal cancer. (10851449)
1997
47
Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer. (8723682)
1996
48
5-Fluorouracil/leucovorin/interferon alpha-2a in patients with advanced colorectal cancer. Effects of maintenance therapy on remission duration. (7850703)
1995
49
Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. (8012355)
1994
50
The relation between serum carcinoembryonic antigen (CEA) and response to chemotherapy in patients with advanced colorectal cancer]. (2321973)
1990

Genetic Variations for Colorectal Cancer

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Colorectal Cancer:

63
id Symbol AA change Variation SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colorectal Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Colorectal Cancer

Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 60Tocris Bioscience, 54Reactome, 56SinoBiological
See all sources

Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.9TP53, CCND1, MSH6, AXIN2, BAX, DCC
212.6CCND1, BRAF, CTNNB1, PPARD, DCC, BAX
3
Hide members
12.6MSH6, AXIN2, BAX, DCC, PPARD, CTNNB1
412.2CCND1, BRAF, CTNNB1, BAX, MSH6, SMAD7
511.9CCND1, BRAF, TLR4, TLR2, CTNNB1, TP53
6
Hide members
11.9CCND1, CTNNB1, PPARD, BAX, AXIN2, TP53
7
Hide members
11.7CCND1, TLR4, TLR2, BAX, TP53
8
Hide members
11.7TP53, BAX, TLR2, TLR4, CCND1
9
Hide members
11.7CCND1, BRAF, TLR4, TLR2, BAX
1011.7CCND1, CTNNB1, DCC, BAX, TP53
1111.7CCND1, CTNNB1, AXIN2, SMAD7, TP53
12
Hide members
11.7TP53, AXIN2, PPARD, CTNNB1, CCND1
1311.4TP53, PLA2G2A, TLR4, CCND1
1411.4CCND1, CTNNB1, BAX, TP53
1511.4CCND1, BRAF, CTNNB1, TP53
1611.4TP53, CTNNB1, BRAF, CCND1
17
Hide members
11.4TP53, BAX, CTNNB1, BRAF
18
Hide members
11.4CCND1, BAX, MSH6, TP53
1911.4TP53, PPARD, CTNNB1, CCND1
2011.4SMAD7, AXIN2, CTNNB1, CCND1
21
Hide members
11.2CCND1, BAX, TP53
22
Hide members
11.2TP53, BAX, CCND1
23
Hide members
11.2CCND1, BRAF, TP53
24
Hide members
11.2BRAF, BAX, TP53
25
Hide members
11.2TLR2, TLR4, BRAF
26
Hide members
11.2TLR2, TLR4, BRAF
2711.2TP53, BAX, PMS2
28
Hide members
11.2TP53, MSH6, BRAF
29
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
11.2BAX, AXIN2, TP53
3011.2AXIN2, CTNNB1, CCND1
3111.2CCND1, CTNNB1, PPARD
32
Hide members
11.2MLH3, PMS2, PMS1
33
Hide members
11.0TLR2, TLR4

Compounds for genes affiliated with Colorectal Cancer

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1vegf4513.3BRAF, CCND1, TLR4, TLR2, CTNNB1, PPARD
2retinoic acid45 2414.1TP53, BRAF, TLR4, CCND1, TLR2, PLA2G2A
3tyrosine4513.0PPARD, CCND1, BRAF, TLR4, SMAD7, CTNNB1
4sb 20358045 6013.9CCND1, BRAF, TLR4, TLR2, BAX, CTNNB1
5cisplatin45 50 60 1115.8CCND1, BRAF, TP53, TLR4, CTNNB1, BAX
6n acetylcysteine4512.6CTNNB1, BAX, SMAD7, TP53, TLR4, CCND1
7ly2940024512.6CTNNB1, TLR4, PLA2G2A, TP53, CCND1, BAX
8paraffin4512.6PMS2, CCND1, BRAF, CTNNB1, BAX, MSH6
9phosphatidylinositol4512.5BAX, CTNNB1, CCND1, TLR4, BRAF, TLR2
10crcs4512.4BRAF, CTNNB1, CCND1, MSH6, TP53, PMS2
11pd 98,0594512.3TLR2, SMAD7, BAX, CTNNB1, BRAF, CCND1
12wortmannin4512.3CTNNB1, TLR2, TLR4, BRAF, CCND1, BAX
13actinomycin d4512.3TLR4, BAX, PLA2G2A, SMAD7, TLR2, TP53
14fatty acid4512.3PLA2G2A, BRAF, TLR2, CTNNB1, PPARD, MT-CO1
15sulindac45 1113.1TP53, BAX, PPARD, CTNNB1, CCND1
16palmitate4512.1PPARD, TLR2, TLR4, CTNNB1, PLA2G2A
17paclitaxel45 50 1114.1BRAF, CCND1, BAX, TP53, CTNNB1
18retinoid4512.1PPARD, BAX, TP53, CTNNB1, CCND1
19serine4512.1CCND1, PLA2G2A, TLR4, TLR2, AXIN2
20doxorubicin45 50 1113.9CCND1, TP53, MSH6, BAX, CTNNB1
21exisulind4511.9PPARD, BAX, CTNNB1, CCND1
22sulindac sulfide4511.9TP53, BAX, PPARD, CCND1
23docosahexaenoic acid45 29 2413.9TLR4, TLR2, PPARD, PLA2G2A
24indole-3-carbinol4511.9BAX, CTNNB1, CCND1, TP53
25c2ceramide4511.8TP53, BAX, TLR4, PLA2G2A
26adpribose4511.8TP53, CTNNB1, CCND1, BAX
27geldanamycin45 50 60 1114.8CTNNB1, BRAF, CCND1, TP53
28sp 60012545 6012.8TP53, TLR2, CCND1, BAX
29gf 109203x45 6012.7TLR2, CCND1, CTNNB1, PLA2G2A
30adriamycin4511.7CCND1, TP53, BAX, CTNNB1
31genistein45 29 60 2 11 2416.7BAX, PLA2G2A, TLR4, CCND1, CTNNB1
32mg 13245 6012.7CTNNB1, TP53, BAX, CCND1
33oligonucleotide4511.6CTNNB1, CCND1, TP53, SMAD7, PPARD, BRAF
34tgf beta14511.6SMAD7, CTNNB1, TLR4, CCND1
35quercetin45 60 11 2414.6PLA2G2A, CTNNB1, BAX, CCND1
36olomoucine45 1112.6BAX, TP53, CCND1
37o6-methylguanine4511.5MSH6, TP53, BRAF
38cetuximab45 50 1113.5CTNNB1, CCND1, BRAF
39depsipeptide4511.4TP53, CCND1
40bbr34644511.3BAX, TP53
41pidotimod4511.3AXIN2, CTNNB1
42inostamycin4511.3BAX, CCND1
43h2o24511.2PLA2G2A, CTNNB1
44arabinogalactan4511.2TLR2, TLR4
45sb-2167634511.2CCND1, CTNNB1
46cycloheximide4511.2TLR2
47dutp4511.1BAX, CCND1, TP53
48chlorophyllin4511.1CCND1, CTNNB1
49mhs-24511.0PMS2, PMS1
50samp4511.0CTNNB1, AXIN2

GO Terms for genes affiliated with Colorectal Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1PMS1, PMS2, CCND1, BRAF, CTNNB1, PPARD
2mismatch repair complexGO:03230011.3MLH3, PMS2, PMS1
3MutLalpha complexGO:03238911.0PMS2, PMS1
4beta-catenin destruction complexGO:03087711.0AXIN2, CTNNB1
5catenin complexGO:01634210.9CTNNB1, SMAD7

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629811.8MSH6, MLH3, PMS2, PMS1
2reciprocal meiotic recombinationGO:00713111.8PMS1, PMS2, MLH3, MSH6
3ATP catabolic processGO:00620011.8MSH6, MLH3, PMS2, PMS1
4positive regulation of apoptotic processGO:04306511.6CTNNB1, DCC, BAX, TP53
5positive regulation of inflammatory responseGO:05072911.5TLR4, TLR2, PLA2G2A
6intrinsic apoptotic signaling pathwayGO:09719311.5BAX, MSH6, TP53
7regulation of centromeric sister chromatid cohesionGO:07060211.3AXIN2, CTNNB1
8somatic recombination of immunoglobulin gene segmentsGO:01644711.3MSH6, PMS2
9maintenance of DNA repeat elementsGO:04357011.3MSH6, AXIN2
10positive regulation of macrophage cytokine productionGO:06090711.3TLR2, TLR4
11cellular response to lipoteichoic acidGO:07122311.2TLR4, TLR2
12adherens junction assemblyGO:03433311.2CTNNB1, SMAD7
13negative regulation of interleukin-17 productionGO:03270011.2TLR2, TLR4
14positive regulation of protein oligomerizationGO:03246111.2TP53, BAX
15positive regulation of tumor necrosis factor biosynthetic processGO:04253511.2TLR4, TLR2
16mitotic G1 DNA damage checkpointGO:03157111.2CCND1, TP53
17dorsal/ventral axis specificationGO:00995011.1CTNNB1, AXIN2
18positive regulation of nitric-oxide synthase biosynthetic processGO:05177011.1TLR4, TLR2
19somatic hypermutation of immunoglobulin genesGO:01644611.0PMS2, MSH6
20I-kappaB phosphorylationGO:00725211.0TLR4, TLR2
21response to salt stressGO:00965111.0TP53, BAX
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.9BRAF, TLR4, DCC
23determination of adult lifespanGO:00834010.9TP53, MSH6

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.2PMS2, CCND1, BRAF, TLR4, TLR2, CTNNB1
2ATPase activityGO:01688711.5MSH6, MLH3, PMS2, PMS1
3protein kinase bindingGO:01990111.4TP53, AXIN2, CTNNB1, CCND1
4MutSalpha complex bindingGO:03240711.4MLH3, PMS2, PMS1
5I-SMAD bindingGO:07041111.4SMAD7, AXIN2, CTNNB1
6mismatched DNA bindingGO:03098311.3PMS1, MLH3, MSH6
7enzyme bindingGO:01989911.1CCND1, CTNNB1, AXIN2, TP53
8single-stranded DNA bindingGO:00369711.1MLH3, PMS2, PMS1
9lipopolysaccharide receptor activityGO:00187511.0TLR4, TLR2

Products for genes affiliated with Colorectal Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colorectal Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet