Colorectal Cancer malady

MedlinePlus: Cancer of the colon or rectum is also called colorectal cancer. in the united states, it is the fourth most common cancer in men and women. caught early, it is often curable. it is more common in people over 50, and the risk increases with age. you are also more likely to get it if you have polyps - growths inside the colon and rectum that may become cancerous a diet that is high in fat a family history or personal history of colorectal cancer ulcerative colitis or crohn's disease symptoms can include blood in the stool, narrower stools, a change in bowel habits and general stomach discomfort. however, you may not have symptoms at first, so screening is important. everyone who is 50 or older should be screened for colorectal cancer. colonoscopy is one method that your doctor can use to screen for colorectal cancer. treatments for colorectal cancer include surgery, chemotherapy, radiation or a combination. nih: national cancer institute²³

MalaCards: Colorectal Cancer, also known as carcinoma of the large intestine, is related to carcinoma and prostatitis. An important gene associated with Colorectal Cancer is DCC (deleted in colorectal carcinoma), and among its related pathways are Metabolic pathways and Molecular Mechanisms of Cancer. The compounds atp and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia: Colorectal cancer, commonly known as colon cancer or bowel cancer, is a cancer from uncontrolled cell...⁴⁴ more...

OMIM: 114500

colorectal cancer 7 44 17 8 33 32 23 carcinoma of the large intestine 43

Disease types for colorectal cancer family:

colorectal cancer 3	colorectal cancer 4
colorectal cancer 10	colorectal cancer 11
colorectal cancer 2	colorectal cancer 5
colorectal cancer 6	colorectal cancer 7
colorectal cancer 8	colorectal cancer 9
colorectal cancer 1

Diseases related to colorectal cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 830)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	363.5	ZNF146, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
2	prostatitis	290.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
3	adenocarcinoma	269.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, KLF10
4	leukemia	265.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	pancreatitis	263.6	ZNF146, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
6	gastric cancer	237.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRRC3B
7	neuronitis	235.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
8	hepatocellular carcinoma	234.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
9	colon cancer	231.5	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, LRP6
10	melanoma	222.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
11	esophagitis	211.3	PIK3CB, PIK3CA, PIK3CG, PIN1, KLF4, KLF5
12	thyroiditis	203.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRPAP1
13	adenoma	183.0	PIK3CA, KLF4, NCAM1, PDCD4, RECK, REG1A
14	hypoxia	173.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP5
15	sarcoma	162.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
16	neuroblastoma	159.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
17	colon carcinoma	152.9	ZNF146, PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG
18	astrocytoma	122.3	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
19	cervicitis	121.8	PIK3CA, PIK3CG, PIN1, LRIG1, KL, RFC1
20	endometrial cancer	121.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
21	ischemia	118.7	PIK3CA, PIK3CG, COG2, KLF4, NCAM1, RETN
22	breast carcinoma	116.6	PIK3CA, PIK3R1, PIK3CG, LRPAP1, RECK, CNR2
23	obesity	116.5	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP5, COG2
24	peritonitis	109.9	LRPAP1, COG2, REG1A, REG4, RELB, RET
25	endometrial carcinoma	107.7	PIK3CB, PIK3CA, PIK3CG, LRPAP1, KLF9, CNR2
26	esophageal cancer	106.5	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
27	lupus erythematosus	106.4	PIK3CD, PIK3CG, COG2, PDCD1LG2, RECK, RETN
28	retinoblastoma	105.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6
29	polyposis	103.8	PIK3CG, PIN1, KLF4, KLF6, REEP5, RET
30	arthritis	102.9	PIK3CD, PIK3CG, PIN1, LRP5, KL, KLF5
31	pneumonia	102.7	COG2, KL, SELE, SETD2, SERPINA1, SERPINE1
32	gonococcal synovitis	102.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
33	cholangiocarcinoma	101.4	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
34	anemia	101.2	NCAM1, SGOL1, KIT, KITLG, VWF, PCNA
35	ovarian carcinoma	97.2	PIK3CA, PIK3CG, PDCD4, RECK, KIT, PCNA
36	lung carcinoma	96.2	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
37	rheumatoid arthritis	95.8	PIK3CD, PIK3CG, PIN1, LRP5, KL, KLF5
38	fibrosis	95.0	PIK3CA, PIK3CG, PIN1, KL, KLF6, RECK
39	myeloid leukemia	95.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40	crohn's disease	92.9	KLF4, REG3A, REG4, RETN, CNR1, SFRP2
41	colon adenocarcinoma	91.3	KLF4, REG4, WARS, BUB1B, VIP, BSG
42	cervical cancer	91.2	PIK3CA, PIK3CG, PIN1, LRIG1, RFC1, SFN
43	oral cancer	91.2	RECK, SFN, SFRP1, SFRP2, SFRP4, PCNA
44	renal cell carcinoma	90.3	PIK3CA, RET, KIT, SFRP1, PCNA, SELP
45	alzheimer's disease	89.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
46	cholesterol	89.1	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
47	myeloma	88.3	PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP5, LRP6
48	insulin resistance	87.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, COG2
49	hepatitis b	84.5	PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6, NCK1
50	atherosclerosis	83.9	PIK3CG, LRP5, LRP6, LRPAP1, COG2, KL

Clinical features from OMIM: 114500

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to colorectal cancer:

²²

MGI Mouse Phenotypes related to colorectal cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	131.7	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
2	cellular phenotype	MP:0005384	122.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
3	immune system phenotype	MP:0005387	81.0	PIK3CD, PIK3R5, LRP5, KL, KLF5, PDCD4
4	nervous system phenotype	MP:0003631	77.5	LRIG1, LRP5, LRP6, LRPAP1, LRRC3B, KL
5	tumorigenesis	MP:0002006	70.1	PIK3CB, PIK3CA, PIK3R2, PIK3R1, LRIG1, KLF10
6	hematopoietic system phenotype	MP:0005397	65.9	KLF6, PDCD1LG2, KIT, VSIG4, SFN, SFRP1
7	embryogenesis phenotype	MP:0005380	56.4	PIK3CB, PIK3CA, LRP5, LRP6, KLF5, KLF6
8	muscle phenotype	MP:0005369	56.0	PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL, KLF5
9	vision/eye phenotype	MP:0005391	55.7	PIK3CA, PIN1, LRP5, LRP6, NCAM1, KIT
10	skeleton phenotype	MP:0005390	51.9	PIK3CD, PIK3CG, LRP6, KLF10, RECK, CNR1
11	renal/urinary system phenotype	MP:0005367	45.0	LRP6, LRPAP1, KL, NCK1, PDCD4, RET
12	no phenotypic analysis	MP:0003012	39.0	PIK3CD, PIK3R1, LRP6, PDCD1LG2, RET, CNR1
13	limbs/digits/tail phenotype	MP:0005371	38.1	LRIG1, LRP5, LRP6, KL, KLF10, RECK
14	liver/biliary system phenotype	MP:0005370	34.6	LRP5, LRP6, KLF6, RECK, RELB, RETN
15	adipose tissue phenotype	MP:0005375	34.4	PIK3CA, PIK3R1, LRP6, KL, RETN, SGMS1
16	endocrine/exocrine gland phenotype	MP:0005379	34.3	LRIG1, LRP5, LRPAP1, KL, KLF4, KLF5
17	craniofacial phenotype	MP:0005382	33.4	LRIG1, LRP5, LRP6, KLF4, KIT, KITLG
18	hearing/vestibular/ear phenotype	MP:0005377	30.1	LRP6, KIT, KITLG, SFN, RB1, RBP1
19	respiratory system phenotype	MP:0005388	26.1	LRP6, KL, KLF5, RELB, RET, SFRP4
20	pigmentation phenotype	MP:0001186	23.8	LRP5, KIT, KITLG, PCBD1, RB1, RBP1
21	other phenotype	MP:0005395	21.6	LRPAP1, KL, RECK, RELB, CNR1, VPS35
22	mortality/aging	MP:0010768	INF	PIK3CB, PIK3CA, LRP5, LRP6, LRPAP1, KL
23	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, LRIG1, LRP6, KL, KLF10
24	normal phenotype	MP:0002873	INF	PIK3R1, LRIG1, LRP5, LRP6, LRPAP1, KLF4
25	reproductive system phenotype	MP:0005389	INF	PIK3CA, LRP6, LRPAP1, KLF4, KLF6, PDCD4
26	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRP5, LRP6, KL, KLF4, KLF9
27	cardiovascular system phenotype	MP:0005385	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
28	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRP6
29	digestive/alimentary phenotype	MP:0005381	INF	LRIG1, LRP6, KL, KLF4, KLF5, RELB

Articles related to colorectal cancer:

(show top 50)    (show all 5319)

id	Title	Authors	Year	Affiliating Genes
1	TCF-3, 4 protein expression correlates with beta-cate nin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not i n sporadic colorectal cancers. (20532534)	Balaz P.... Schackert H.K.	2010	CTNNB1, TCF7L2, TCF7L1
2	Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. (20056627)	Levine A.J.... Haile R.W.	2010	MTHFR
3	Survival of MUTYH-associated polyposis patients with colorectal cancer and matched control colorectal cancer patients. (21044966)	Nielsen M.... Hes F.J.	2010	MUTYH
4	Immunohistochemistry as first-line screening for dete cting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel . (19701074)	Shia J.... Klimstra D.S.	2009	MSH6, PMS2
5	Penetrance of colorectal cancer among MLH1/MSH2 carri ers participating in the colorectal cancer familial registry in Ontario. (19698169)	Choi Y.H.... Briollais L.	2009	MSH2, MLH1
6	Expression of gamma-synuclein in colorectal cancer ti ssues and its role on colorectal cancer cell line HCT116. (19859996)	Ye Q.... Zheng M.H.	2009	SNCG
7	Previstage GCC Colorectal Cancer Staging Test: A New Molecular Test to Identify Lymph Node Metastases and Provide More Accurate Information about the Stage of Patients with Colorectal Cancer. (19351210)	Carlson M.R.	2009	GUCY2C
8	Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. (19016757)	Koga Y.... Matsumura Y.	2008	TP53, MMP7, PTGS2
9	Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin- dependent transcription. (18591935)	Fukuyama R.... Sizemore N.	2008	CTNNB1, MCC
10	Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer. (18425389)	Oshima T.... Imada T.	2008	MMP2, MMP9, MMP14
11	Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part II. The utility of microsatellite instability testing. (18556776)	Zhang L.	2008	BRAF, MLH1, MSH6
12	UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study. (18594531)	Kweekel D.M.... Guchelaar H.J.	2008	UGT1A1
13	Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): a novel biological marker in the detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy study group on colorectal cancer detection. (18224568)	Nielsen H.J.... .	2008	TIMP1
14	Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer. (18636198)	Oshima T.... Imada T.	2008	IGF1R, MMP7, IGF1
15	Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. (18027856)	Talseth B.A.... Scott R.J.	2008	CCND1, AURKA
16	Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. (17545526)	Bettstetter M.... Dietmaier W.	2007	MLH1
17	Microsatellite analysis and hMLH1/hMSH2 expression d etection in young patients with colorectal cancer: value in screening hereditar y nonpolyposis colorectal cancer (17584637)	Yang L.... Zhang J.H.	2007	MLH1
18	Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients. (17406361)	Haug U.... Brenner H.	2007	PKM
19	Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. (17908962)	SA!nchez-de-Abajo A.... Caldes T.	2007	HRAS, BRAF, APC
20	Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer. (17454882)	Stormorken A.T.... Moller P.	2007	MSH2, MLH1, MSH6
21	Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH. (16645203)	Gorgens H.... Muller A.	2006	MUTYH
22	Identification of mismatch repair gene mutations in y oung patients with colorectal cancer and in patients with multiple tumours asso ciated with hereditary non-polyposis colorectal cancer. (16636019)	Niessen R.C.... Kleibeuker J.H.	2006	MSH2, MLH1, MSH6
23	Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany. (17095871)	Lamberti C.... Mathiak M.	2006	MSH2, MLH1, MSH6
24	A new quantitative DNA-methylation analysis of MSI colorectal cancers helps to separate sporadic colorectal cancers from HNPCC-candidates (17867602)	Bettstetter M.... Dietmaier W.	2006	BRAF
25	Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients. (16857798)	You J.F.... Tang R.	2006	MUC1, MUC3A
26	Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. (16421660)	Yamaguchi T.... Miyaki M.	2006	TGFBR2, PTEN, BAX
27	Frequency of hereditary non-polyposis colorectal cancer among Uruguayan patients with colorectal cancer. (15952990)	Sarroca C.... Lynch H.	2005	MSH2, MLH1, MSH6
28	Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. (15805302)	Hagiwara T.... Imaizumi N.	2005	CYP7A1
29	Preoperative serum levels of the carcinoembryonic antigen in hereditary non-polyposis colorectal cancer compared to levels in sporadic colorectal cancer. (16122885)	Schiemann U.... Holinski-Feder E.	2005	PSG2
30	Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe) (15138699)	RA1schoff J.... BA1ttner R.	2004	MSH2, MSH6, PMS2
31	Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. (15449173)	Kim I.J.... Park J.G.	2004	BRAF, APC, CTNNB1
32	Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). (15596632)	Watson P.... Roy H.K.	2004	MSH2, MLH1
33	BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. (14734469)	Deng G.... Kim Y.S.	2004	BRAF, MLH1
34	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. (15546509)	Yin G.... Imaizumi N.	2004	MTHFR
35	Allelic imbalance in colorectal cancer at the CRAC1 locus in early-onset colorectal cancer. (12885466)	Popat S.... Houlston R.S.	2003	CRAC1
36	Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry. (11910346)	Terdiman J.P.... Kim Y.S.	2002	MSH2, MLH1
37	Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene. (11782355)	Shin K.H.... Park J.G.	2002	MSH2, MLH1
38	Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer. (11819827)	Li X.G.... Wang Y.Q.	2001	WSB2
39	Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions (11707995)	Ishida H.... Miura T.	2001	DPYD, TYMP
40	Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer. The RANX05 Colorectal Cancer Study Group. (11005561)	Nielsen H.J.... Brunner N.	2000	SERPINE1, CRP
41	Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients. (10690536)	Shin K.H.... Park J.G.	2000	TGFBR2
42	Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population. (10378595)	Shashidharan M.... Lynch H.T.	1999	MSH2, MLH1
43	Microsatellite instability, a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer. (10323887)	Lamberti C.... Propping P.	1999	MLH1
44	Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer. (9559627)	Yuan Y.... Park J.-G.	1998	MSH2, MLH1
45	Germline mutation analysis in hMLH 1 and hMSH 2 genes in hereditary nonpolyposis colorectal cancer and colorectal cancer patients with familial history (9845760)	Wang Y.... Propping P.	1998	MLH1
46	Correlations between cell proliferating activity and apoptosis in the colorectal cancer and apoptosis in the mucosa adjacent to colorectal cancer (9263520)	Watanabe I.... Tanigawa N.	1997	PCNA
47	Interleukin-7 (IL-7) in colorectal cancer: IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes. (9042431)	Maeurer M.J.... Lotze M.T.	1997	IL7
48	Randomized trial assessing the addition of interferon alpha-2a to fluorouracil and leucovorin in advanced colorectal cancer. Colorectal Cancer Working Party of the United Kingdom Medical Research Council. (8708718)	Seymour M.T.... Taylor I.	1996	IFNA2, IFNA1
49	Colorectal cancer: future population screening for early colorectal cancer. (7577053)	Blum H.E.	1995	RAN
50	'Tomudex' (ZD1694): results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leuco penia. The 'Tomudex' Colorectal Cancer Study Group. (8562146)	Cunningham D.... Perez-Manga G.	1995	TYMS

Genes related to colorectal cancer according to GeneCards:

(show top 50)    (show all 1852)

id	Symbol	Description	Score	GeneCards Section Context
1	DCC	deleted in colorectal carcinoma	11.1	Databases, Publications, Aliases & Descriptions, Pathways & Interactions (show all 5 sections) Summaries
2	GALNT12	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	11.1	Publications, Aliases & Descriptions, Summaries
3	MLH3	mutL homolog 3 (E. coli)	11.1	Publications, Summaries
4	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	11.1	Publications, Summaries
5	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.1	Publications, Summaries
6	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.1	Publications, Pathways & Interactions, Summaries
7	SMAD7	SMAD family member 7	11.1	Publications, Summaries
8	CRCS10	Colorectal cancer, susceptibility to, 10	11.0	Aliases & Descriptions
9	CRCS7	colorectal cancer, susceptibility to, 7	11.0	Aliases & Descriptions
10	CRCS8	Colorectal cancer, susceptibility to, 8	11.0	Aliases & Descriptions
11	CRCS11	Colorectal cancer, susceptibility to, 11	11.0	Aliases & Descriptions, Publications
12	CRCS5	Colorectal cancer, susceptibility to, 5	11.0	Publications, Aliases & Descriptions
13	CRCS6	colorectal cancer, susceptibility to, 6	11.0	Publications, Aliases & Descriptions
14	CRCS9	colorectal cancer, susceptibility to, 9	11.0	Publications, Aliases & Descriptions
15	AXIN2	axin 2	11.0	Publications, Pathways & Interactions, Summaries
16	CRCS2	Colorectal cancer, susceptibility to, 2	11.0	Publications, Aliases & Descriptions
17	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications, Pathways & Interactions, Summaries
18	SFRP2	secreted frizzled-related protein 2	11.0	Publications, Summaries
19	LGALS4	lectin, galactoside-binding, soluble, 4	11.0	Publications, Summaries
20	MAPRE1	microtubule-associated protein, RP/EB family, member 1	11.0	Publications, Summaries
21	PPARD	peroxisome proliferator-activated receptor delta	11.0	Publications, Summaries
22	MAPRE2	microtubule-associated protein, RP/EB family, member 2	11.0	Publications, Functions, Summaries
23	MCC	mutated in colorectal cancers	11.0	Publications, Transcripts, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
24	HOXB8	homeobox B8	11.0	Summaries
25	HOXB6	homeobox B6	11.0	Summaries
26	RPS12	ribosomal protein S12	11.0	Publications, Summaries
27	CHSY1	chondroitin sulfate synthase 1	11.0	Publications, Summaries
28	PDGFRL	platelet-derived growth factor receptor-like	11.0	Publications, Summaries
29	RPL5	ribosomal protein L5	11.0	Publications, Summaries
30	RPS9	ribosomal protein S9	11.0	Summaries
31	ANTXR1	anthrax toxin receptor 1	11.0	Publications, Summaries
32	CABLES1	Cdk5 and Abl enzyme substrate 1	11.0	Publications, Summaries
33	EPDR1	ependymin related protein 1 (zebrafish)	11.0	Aliases & Descriptions
34	TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	11.0	Aliases & Descriptions
35	CBLN4	cerebellin 4 precursor	11.0	Summaries
36	HOTAIR	HOX transcript antisense RNA	11.0	Summaries
37	WNT10A	wingless-type MMTV integration site family, member 10A	11.0	Pathways & Interactions, Summaries
38	WNT6	wingless-type MMTV integration site family, member 6	11.0	Pathways & Interactions, Summaries
39	RPL28	ribosomal protein L28	11.0	Summaries
40	RPS10	ribosomal protein S10	11.0	Summaries
41	RPS29	ribosomal protein S29	11.0	Summaries
42	RPL27A	ribosomal protein L27a	11.0	Summaries
43	RPS5	ribosomal protein S5	11.0	Summaries
44	SLC16A7	solute carrier family 16, member 7 (monocarboxylic acid transporter 2)	11.0	Summaries
45	DOCK4	dedicator of cytokinesis 4	11.0	Summaries
46	PTPRR	protein tyrosine phosphatase, receptor type, R	11.0	Summaries
47	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
48	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
49	MSH6	mutS homolog 6 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
50	APC	adenomatous polyposis coli	11.0	Publications, Pathways & Interactions

Pathways related to colorectal cancer according to GeneDecks:

(show top 50)    (show all 428)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	44.1	KL, SGMS1, GCDH, GCNT1, GCNT3, NAT1
2	Molecular Mechanisms of Cancer36	40.2	PIK3R3, PIK3R2, PIK3R4, PIK3R1, PIK3CG, LRP5
3	Cellular Apoptosis Pathway36	26.7	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
4	p53 Mediated Apoptosis36	25.1	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
5	Intracellular Calcium Signaling36	23.7	KIT, KITLG, VEGFB, VEGFC, BMP1, BMP2
6	p70S6K Signaling36	22.8	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
7	Angiogenesis3	20.1	RECK, SERPINB5, VHL, VEGFB, VEGFC, KDR
8	MIF Regulation of Innate Immune Cells36	19.9	BMP1, BMP2, BMP3, BMP4, BMP6, BMP7
9	DNA Repair Mechanisms36	18.8	PCNA, BRCA1, BRCA2, RAD51, RAD50, LIG3
10	Chronic myeloid leukemia20	18.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
11	Endocytosis20	18.2	RET, KIT, ZFYVE9, KDR, LDLR, CDC42
12	Signaling Involved in Cardiac Hypertrophy36	17.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, RAC3
13	ErbB signaling pathway20	17.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14	Development IGF-RI signaling10	17.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R1, RELB
15	Development Prolactin receptor signaling10	16.4	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VAV1
16	Cell adhesion molecules (CAMs)20	16.2	NCAM1, PDCD1LG2, SELP, CLDN2, CLDN4, CLDN7
17	Signal transduction PTEN pathway10	16.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
18	Ceramide Pathway36	15.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RAF1, BAD
19	PGC1Alpha Pathway36	15.4	BMP1, BMP2, BMP3, BMP4, BMP6, BMP7
20	Leishmaniasis20	14.9	JUN, JAK1, JAK2, ITGB1, ITGB2, FOS
21	TCR Signaling36	14.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, VAV1, RAC3
22	Th17 Differentiation37	14.3	JAK1, JAK2, CD28, CD86, CD80, IL12B
23	Cell adhesion PLAU signaling10	14.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
24	Chemokine signaling pathway20	14.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
25	IL-4 Pathway36	13.9	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, RAF1
26	Type II diabetes mellitus20	13.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
27	FGF Pathway36	13.7	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RALGDS, RAF1
28	Development EPO-induced Jak-STAT pathway10	13.5	MYC, RAF1, BCL2, BCL2L1, XIAP, JAK2
29	Transcription P53 signaling pathway10	13.5	RELB, VEGFA, ATR, CDK2, CDKN2A, APEX1
30	IL-3 Pathway36	13.4	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, RAF1
31	Immune response_Fc epsilon RI pathway41	13.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, RELB
32	Development_EPO-induced Jak-STAT pathway41	13.3	MYC, BCL2, BCL2L1, XIAP, JAK2, GRB2
33	Development CNTF receptor signaling10	13.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
34	Progesterone-mediated oocyte maturation20	13.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
35	Development FGFR signaling pathway10	12.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
36	Development_GDNF family signaling41	12.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, NCK1, RELB
37	Development_Leptin signaling via PI3K-dependent pathway41	12.4	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, LEP
38	Regulation of lipid metabolism_Insulin signaling-generic cascades41	11.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
39	Development_Leptin signaling via JAK/STAT and MAPK cascades41	11.6	RAF1, LEPR, JAK2, GRB2, PTPN1, PTPN11
40	Signal transduction_IP3 signaling41	11.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, RAF1
41	Development_A2B receptor- action via G-protein alpha s41	11.3	PIK3CB, PIK3CD, PIK3CA, RELB, BRAF, VAV1
42	Development EGFR signaling pathway10	11.1	EREG
43	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling41	10.4	PIK3R2, PIK3R1, TXN, PTPN11, CYSLTR2, CYSLTR1
44	CRHR Pathway36	10.3	CNR1, BRAF, VEGFC, RAF1, BDNF, JUN
45	Chemotaxis_CXCR4 signaling pathway41	10.0	VAV1, RAC1, LCK, JAK2, CDC42, GRB2
46	Development_A3 receptor signaling41	9.8	PIK3R5, PIK3CG, RELB, MYC, RAF1, CHUK
47	Development_A1 receptor signaling41	9.4	PIK3R5, PIK3CG, RELB, RAF1, RAC1, CHUK
48	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics34	8.3	ARRB1, MAPK1, GNAS, GNB1, GNB2, GNB3
49	G-protein signaling_G-Protein alpha-i signaling cascades41	7.5	BRAF, RAF1, GRB2, MAP2K2, MAPK3, MAPK1
50	Acute myeloid leukemia20	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1

Compounds related to colorectal cancer according to GeneDecks:

(show top 50)    (show all 432)

id	Compound	Score	Top Affiliating Genes
1	atp32	55.6	PIK3CB, PIK3CA, RFC1, NCAM1, RECK, RET
2	cholesterol32 9 18 9	55.5	PIK3CB, PIK3CA, PIK3R1, LRP5, LRPAP1, COG2
3	paclitaxel32 34 9 9	49.6	PIK3CA, PIK3CG, PIN1, KIT, KITLG, PCNA
4	fatty acid32	33.8	COG2, RECK, RETN, SFN, GC, RBP1
5	5-aza-2deoxycytidine32	32.9	KITLG, SFRP1, PCNA, RBP1, SERPINB5, VIM
6	indomethacin32 9 9	34.9	CNR1, PCNA, VIM, VIP, LPL, MYC
7	glucose32	32.9	REG3A, KIT, SETD2, SEPP1, BRAF, BRS3
8	forskolin32 42 9 9	35.1	PIK3R1, RETN, CNR2, VIM, VIP, BRAF
9	curcumin32	31.6	PIK3CG, NAT1, VEGFA, VCAM1, MYC, RAF1
10	12-o-tetradecanoylphorbol 13-acetate32	31.5	NCAM1, RET, RB1, SERPINB2, BRAF, MYC
11	resveratrol32 9 18 9	32.6	PIK3CA, PIK3CG, PCNA, RB1, BSG, BRCA1
12	imatinib32 34 9 9	32.3	PIK3CA, PIK3R1, PIK3CG, RET, KIT, KITLG
13	phosphotyrosine32	27.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCK1, RECK
14	gemcitabine32 34 9 9	28.9	PCNA, BRCA1, VEGFA, BNIP3, MYC, RAD51
15	gtp32	24.6	PIK3CA, PIK3R1, RECK, CNR2, PCBD1, SEPT9
16	bromodeoxyuridine32	23.9	PIK3CA, PIK3R1, NCAM1, KITLG, PCNA, RB1
17	simvastatin32 34 42 9 18 9	27.0	COG2, KITLG, VWF, SELE, SELP, SERPINE1
18	heparan sulfate32 18	22.4	NCAM1, RET, GC, SERPINE1, VIM, BSG
19	atorvastatin32 34 9 18 9	24.7	COG2, RETN, VWF, SELE, SELP, VEGFA
20	azathioprine32 34 9 9	23.1	PCNA, VIM, MYOD1, BMP2, BMP4, RARB
21	tetracycline32 9 9	22.1	VWF, GCNT1, RB1, MYCN, BMP2, RAC1
22	chloride32	20.1	RECK, VIP, LPAR3, BLVRB, CLCA2, CLU
23	sucrose32 9 18 9	22.6	LRPAP1, RECK, BSG, MYOD1, RAD51, BLZF1
24	endotoxin32	19.4	RECK, RETN, GC, SERPINB2, BLVRB, LEPR
25	latex32	19.1	KITLG, VWF, BLZF1, LGALS3, CHEK2, CEACAM5
26	trastuzumab32 34 9 9	21.9	PIK3CA, PIK3R1, PIK3CG, KIT, VEGFC, RAF1
27	purine32 18	19.3	NCAM1, UPF2, UMPS, ZAP70, MUC1, LBR
28	valproic acid32 34 9 18 9	22.0	COG2, NCAM1, KITLG, MYCN, BDNF, UGT1A
29	sodium nitroprusside32	16.9	VWF, PCNA, VIP, MYB, BMP6, BLVRB
30	dutp32	16.7	PCNA, BIRC5, CLU, PARP1, BCL2, BCL2L1
31	dihydrofolate32	16.4	KITLG, RB1, MYBL2, MTHFR, MTR, MSH3
32	xanthine32 18	17.4	NAT2, MUC5AC, XDH, MPG, MPO, CD14
33	ionomycin32	16.0	PIK3CB, SETD2, VAV1, BCL10, CHUK, LCK
34	tcdd32	15.8	SERPINB2, RARS, UGT1A, UGT1A1, UGT1A6, CDK4
35	mevalonate32	15.5	SERPINE1, VCAM1, BMP2, RAC1, BCL2L1, LDLR
36	sodium arsenite32	15.2	MYC, RAF1, LBR, CFLAR, JUN, GSR
37	aphidicolin32	15.2	PCNA, RB1, BRCA1, MYC, RAD51, UNG
38	sn 3832 42	16.1	BCL2L1, CHEK1, CHEK2, UGT1A, UGT1A1, UGT1A7
39	phenylarsine oxide32	15.1	PIK3CG, SELE, SELP, BCR, LCK, CDKN3
40	pertussis32	15.0	PIK3CG, VIP, LPAR1, LPAR2, JUN, ITGAL
41	bicalutamide32 42 9 9	18.0	PIK3CG, VDR, CHGA, CDK2, CDKN3, AR
42	aprotinin32 9 9	16.9	VWF, SELP, SERPINB2, VIP, FURIN, MMP13
43	progestins32	14.6	LIPC, JAK2, MMP3, MKI67, ARSH, AR
44	sp 60012532 42	15.6	PIK3CG, VCAM1, BID, BIK, BIRC2, BIRC3
45	ang ii32	14.4	PIK3CG, VEGFA, JAK2, CD36, ANPEP, MAPK8
46	c-peptide32	14.4	RETN, LEP, IRS1, INSR, IL7, CCK
47	carbamazepine32 34 9 9	16.9	COG2, UGT1A, CD36, GSR, IGFBP3, ALPP
48	staurosporin32	13.7	PIK3CA, PIK3CG, BCL2, BCL2L1, JUN, CDKN3
49	poly(i-c)32	13.5	VCAM1, CHUK, IRF1, IL12B, IL15, IL18
50	lipoteichoic acid32	13.1	SELE, CD14, IRAK1, IL10, IL12B, IL18

Cellular components related to colorectal cancer according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	99.7	ZNF146, ZNF346, PIK3CB, PIK3R5, PIN1, KLF10
2	cytoplasm	GO:005737	96.3	ZNF146, ZNF346, PIK3R5, PIK3CG, PIN1, KLF6
3	cytosol	GO:005829	76.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R4
4	plasma membrane	GO:005886	72.5	PIK3CD, PIK3R1, PIK3CG, LRP5, LRP6, LRPAP1
5	extracellular region	GO:005576	53.0	LRPAP1, KL, NCAM1, PDCD1LG2, REG1A, REG4
6	extracellular space	GO:005615	46.8	KL, REG3A, KIT, KITLG, SFN, SFRP1
7	nucleoplasm	GO:005654	41.5	PIN1, RFC1, RFC3, PCNA, RB1, NBN
8	integral to plasma membrane	GO:005887	39.5	KL, RET, SGCE, CNR1, CNR2, SELP
9	cell surface	GO:009986	25.9	LRP6, LRPAP1, NCAM1, SFRP1, SFRP4, VEGFA
10	membrane	GO:016020	25.2	PIK3R5, PIK3CG, RECK, VPS35, GCNT3, SELENBP1
11	perinuclear region of cytoplasm	GO:048471	23.3	BUB1B, GC, SELE, SEPT9, LMNA, RAD51
12	proteinaceous extracellular matrix	GO:005578	18.3	VWF, SFRP1, SERPINA1, VEGFA, BMP4, LGALS1
13	external side of plasma membrane	GO:009897	17.4	NCAM1, KIT, VWF, SELP, VCAM1, KDR
14	membrane raft	GO:045121	16.2	SELE, BSG, BCL10, LCK, FURIN, JAK2
15	platelet alpha granule lumen	GO:031093	14.8	VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, VEGFC

Biological processes related to colorectal cancer according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	37.0	PIK3CB, PIK3CD, RET, CNOT7, KIT, KITLG
2	apoptotic process	GO:006915	36.9	ZNF346, PDCD4, SGMS1, SFN, BUB1, BUB1B
3	positive regulation of transcription from RNA polymerase II promoter	GO:045944	34.6	LRP5, LRP6, KLF4, KLF6, NCK1, CNOT7
4	positive regulation of cell proliferation	GO:008284	31.9	LRP5, KLF5, REG1A, KIT, SFRP1, SFRP2
5	positive regulation of transcription, DNA-dependent	GO:045893	31.5	LRP5, LRP6, KLF4, KLF5, KLF6, RET
6	negative regulation of cell proliferation	GO:008285	31.0	KLF10, KLF4, WARS, SFN, SFRP1, SFRP2
7	negative regulation of apoptotic process	GO:043066	28.3	PIK3CG, SFRP1, SERPINE1, BRAF, VEGFA, BNIP3L
8	negative regulation of transcription from RNA polymerase II promoter	GO:000122	28.2	KLF10, KLF4, RBBP8, VHL, VDR, MYC
9	blood coagulation	GO:007596	27.4	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
10	response to drug	GO:042493	26.7	SFRP1, SFRP2, NBN, VEGFC, LPL, MYC
11	cell adhesion	GO:007155	26.0	NCAM1, KITLG, VWF, SELP, VCAM1, RAC1
12	cell proliferation	GO:008283	25.8	KLF10, REG3A, KITLG, KIF2C, SFN, PCNA
13	negative regulation of transcription, DNA-dependent	GO:045892	25.4	KLF4, PDCD4, SFRP1, SFRP2, BTRC, RB1
14	anti-apoptosis	GO:006916	23.5	PIK3CA, SERPINB2, VIMP, BRAF, VHL, VEGFB
15	positive regulation of apoptotic process	GO:043065	23.3	LRP6, CNR1, SFRP1, SFRP2, SFRP4, SEPT4
16	angiogenesis	GO:001525	23.3	PIK3CA, PIK3CG, KLF5, WARS, SETD2, SERPINE1
17	DNA repair	GO:006281	23.0	RFC1, RFC3, PCNA, RBBP8, NBN, BRCA1
18	inflammatory response	GO:006954	22.6	PIK3CD, PIK3CG, CNR2, KIT, SELE, SELP
19	immune response	GO:006955	22.1	PDCD1LG2, CNR2, VAV1, BMP6, BMPR1A, ZEB1
20	xenobiotic metabolic process	GO:006805	21.5	NAT1, NAT2, PAOX, UGT1A1, UGT1A6, UGT1A9
21	induction of apoptosis	GO:006917	21.4	KLF10, BOK, BNIP3, BNIP3L, BIK, BCL10
22	response to hypoxia	GO:001666	21.1	SERPINA1, VEGFA, VCAM1, BNIP3, BMP2, RAF1
23	axon guidance	GO:007411	20.8	NCAM1, NCK1, SEMA6A, RAF1, RAC1, RAC2
24	platelet activation	GO:030168	20.1	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
25	positive regulation of cell migration	GO:030335	19.5	RET, VEGFA, BMP2, KDR, LEF1, LAMB1
26	protein phosphorylation	GO:006468	19.5	PIK3CD, PIK3R4, RET, BRAF, MYOD1, BMPR1A
27	response to lipopolysaccharide	GO:032496	18.4	CNR1, CNR2, SELE, SELP, SERPINA1, UGT1A1
28	cell cycle arrest	GO:007050	18.2	BTG4, RB1, NBN, MYC, RASSF1, SART1
29	response to estradiol stimulus	GO:032355	17.8	SFRP4, GC, SERPINA1, BRCA2, VDR, BMP4
30	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	17.7	BOK, MYC, BCL2L11, BBC3, LCK, BAD
31	cytokine-mediated signaling pathway	GO:019221	17.6	PIN1, KLF6, NCAM1, KIT, VCAM1, CIITA
32	positive regulation of protein phosphorylation	GO:001934	17.6	PIN1, VEGFA, BMP2, BMP4, MTOR, AXIN1
33	insulin receptor signaling pathway	GO:008286	17.5	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R4, PIK3R1
34	regulation of cell proliferation	GO:042127	17.4	PIN1, KIT, SERPINE1, BRCA1, BMPR2, BID
35	positive regulation of gene expression	GO:010628	17.2	RELB, KIT, SFRP4, BRAF, VEGFA, VDR
36	aging	GO:007568	16.9	KL, CNR1, VDR, VCAM1, BAK1, FURIN
37	heart development	GO:007507	16.9	PCNA, VCAM1, BMP2, RAF1, ATM, MRE11A
38	phosphatidylinositol-mediated signaling	GO:048015	16.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PCNA, BUB1B
39	leukocyte migration	GO:050900	16.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELP, BSG
40	induction of apoptosis by intracellular signals	GO:008629	16.5	BNIP3, MYC, BID, CLU, BCL2, BCL2L1
41	protein autophosphorylation	GO:046777	16.5	KIT, MYO3A, PAK1, KDR, CHEK2, ZAP70
42	positive regulation of angiogenesis	GO:045766	16.2	SFRP2, SERPINE1, VEGFA, KDR, CD34, MMP9
43	nerve growth factor receptor signaling pathway	GO:048011	15.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, BRAF, VAV1
44	positive regulation of MAPK cascade	GO:043410	15.3	KIT, LPAR1, LPAR2, LPAR3, KDR, LEP
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	15.3	KITLG, VEGFA, VEGFB, MTOR, JAK2, CD36
46	activation of MAPK activity	GO:000187	15.1	PIK3CB, KIT, LPAR1, LPAR2, LPAR3, CDK1
47	canonical Wnt receptor signaling pathway	GO:060070	15.1	LRP5, LRP6, SFRP1, MYC, BCL9, BCL9L
48	positive regulation of cell division	GO:051781	14.7	VEGFA, VEGFB, VEGFC, YBX1, FIGF, FGF1
49	fibroblast growth factor receptor signaling pathway	GO:008543	14.6	PIK3CA, PIK3R1, KL, BRAF, RAF1, CHUK
50	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	14.5	KIT, SELP, KDR, JAK2, FLT1, FLT3

Molecular functions related to colorectal cancer according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	41.3	PIK3CB, PIK3CD, PIK3CA, PIK3R4, PIK3CG, RFC1
2	protein heterodimerization activity	GO:046982	22.9	BRAF, VEGFA, VEGFB, BOK, BNIP3, BNIP3L
3	enzyme binding	GO:019899	22.4	VIMP, BRCA1, VHL, RAC1, BLZF1, BIRC5
4	transcription factor binding	GO:008134	21.9	RB1, NBN, BRD7, VHL, MYC, MYOD1
5	growth factor activity	GO:008083	20.2	REG1A, KITLG, VEGFA, VEGFB, VEGFC, BMP1
6	protein kinase binding	GO:019901	19.9	VIM, LLGL1, ZFP36, PAK1, PARK2, BCL10
7	receptor binding	GO:005102	19.9	LRP6, NCK1, SERPINE1, LPL, BMP2, BMP3
8	transcription regulatory region DNA binding	GO:044212	19.1	KLF4, BRCA1, BRD7, LEF1, CIITA, XRCC5
9	cytokine activity	GO:005125	18.0	KITLG, VEGFA, BMP1, BMP2, BMP3, BMP4
10	heparin binding	GO:008201	17.2	ZNF146, LRPAP1, SFRP1, SELP, VEGFA, VEGFB
11	beta-catenin binding	GO:008013	16.0	BTRC, BCL9, BCL9L, LEF1, AXIN1, AXIN2
12	ubiquitin protein ligase binding	GO:031625	15.8	RB1, BRCA1, MYOD1, RAD18, BLZF1, BID
13	signal transducer activity	GO:004871	15.2	KL, CNOT7, CLOCK, LGALS1, CHKA, S100A9
14	protein tyrosine kinase activity	GO:004713	15.0	RET, KIT, KDR, BCR, SCYL1, ZAP70
15	protein homodimerization activity	GO:042803	INF	LRP6, KIT, VWF, VEGFA, VEGFB, BNIP3
16	sequence-specific DNA binding transcription factor activity	GO:003700	INF	KLF10, KLF4, KLF5, KLF6, KLF9, RELB
17	identical protein binding	GO:042802	INF	SFRP1, PCBD1, PCNA, VIM, BNIP3, BNIP3L
18	protein binding	GO:005515	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R4, PIK3R1