CRC
MCID: CLR023
MIFTS: 97

Colorectal Cancer (CRC) malady

Categories: Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer

Aliases & Descriptions for Colorectal Cancer:

Name: Colorectal Cancer 54 38 12 24 24 66 29 13 13 52 41 14 69
Colon Cancer 54 12 24 66 52 14
Colon Carcinoma 12 24 52 14 69
Colorectal Cancer, Somatic 54 24 13
Colon Cancer, Somatic 54 13
Colorectal Carcinoma 52 69
Colorectal Neoplasms 42 69
Colonic Neoplasms 42 69
Crc 24 66
Colonic Adenoma Recurrence, Reduced Risk of 54
Malignant Tumor of Colon 69
Carcinoma of Colon 12
Colonic Carcinoma 12
Neoplasm of Colon 29

Classifications:



Summaries for Colorectal Cancer

OMIM : 54 Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and... (114500) more...

MalaCards based summary : Colorectal Cancer, also known as colon cancer, is related to proctitis and colorectal cancer, hereditary nonpolyposis, type 1, and has symptoms including renal cell carcinoma, neoplasm of the stomach and transitional cell carcinoma of the bladder. An important gene associated with Colorectal Cancer is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Colorectal cancer and Signaling by GPCR. The drugs Avastin and Campostar have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and cellular

Disease Ontology : 12 A large intestine cancer that is located in the colon and/or located in the rectum.

MedlinePlus : 41 the colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

UniProtKB/Swiss-Prot : 66 Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

Wikipedia : 71 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Colorectal Cancer

Diseases in the Colorectal Cancer family:

Colorectal Cancer 6 Colorectal Cancer 2
Colorectal Cancer 1 Colorectal Cancer 5
Colorectal Cancer 7 Colorectal Cancer 12
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11 Familial Colorectal Cancer
Hereditary Colorectal Cancer Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
id Related Disease Score Top Affiliating Genes
1 proctitis 30.3 CCND1 CTNNB1 PIK3CA TP53
2 colorectal cancer, hereditary nonpolyposis, type 1 12.3
3 colorectal cancer 1 12.3
4 colorectal cancer 3 12.2
5 colorectal cancer, hereditary nonpolyposis, type 5 12.2
6 colorectal cancer, hereditary nonpolyposis, type 4 12.2
7 colorectal cancer, hereditary nonpolyposis, type 6 12.2
8 colorectal cancer 10 12.2
9 colorectal cancer, hereditary nonpolyposis, type 7 12.2
10 colorectal cancer, hereditary nonpolyposis, type 8 12.2
11 oligodontia-colorectal cancer syndrome 12.2
12 colorectal cancer, hereditary nonpolyposis, type 2 12.2
13 colorectal cancer 12 12.2
14 familial colorectal cancer 12.1
15 colorectal cancer 2 12.0
16 colorectal cancer 5 12.0
17 adenosquamous colon carcinoma 12.0
18 familial colorectal cancer type x 12.0
19 transverse colon cancer 12.0
20 ascending colon cancer 12.0
21 colon carcinoma in situ 12.0
22 lynch syndrome 12.0
23 descending colon cancer 12.0
24 hereditary colorectal cancer 12.0
25 colorectal cancer 8 11.9
26 colorectal cancer, childhood 11.8
27 colorectal cancer 6 11.8
28 colorectal cancer 9 11.8
29 colorectal cancer 7 11.8
30 colorectal cancer 11 11.8
31 chek2-related susceptibility to breast and colorectal cancer 11.8
32 colorectal cancer susceptibility 10 11.8
33 selection of therapeutic option in colorectal cancer 11.8
34 colorectal cancer susceptibility 12 11.8
35 familial adenomatous polyposis 11.3
36 adenomatous polyposis coli 11.3
37 mutyh-associated polyposis 11.1
38 muir-torre syndrome 11.1
39 colorectal adenocarcinoma 11.1
40 attenuated familial adenomatous polyposis 11.1
41 tgbfr2-related lynch syndrome 11.0
42 epcam-related lynch syndrome 11.0
43 colon squamous cell carcinoma 11.0
44 mismatch repair cancer syndrome 10.9
45 rectal neoplasm 10.9
46 muscular dystrophy-dystroglycanopathy , type b, 2 10.9 APC BAX BRAF CCND1 CTNNB1 MLH3
47 colonic benign neoplasm 10.8
48 small intestine cancer 10.8
49 polyposis, juvenile intestinal 10.8
50 gastric cancer risk after h. pylori infection 10.8

Comorbidity relations with Colorectal Cancer via Phenotypic Disease Network (PDN): (show all 22)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Ascending Colon Cancer
Cecal Benign Neoplasm Deficiency Anemia
Descending Colon Cancer Familial Atrial Fibrillation
Heart Disease Hepatic Flexure Cancer
Hydronephrosis Intestinal Obstruction
Intestinal Perforation Iron Deficiency Anemia
Neutropenia Paralytic Ileus
Protein-Energy Malnutrition Rectal Neoplasm
Rectosigmoid Junction Neoplasm Small Intestine Cancer
Splenic Flexure Cancer Transverse Colon Cancer

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to Colorectal Cancer

Symptoms & Phenotypes for Colorectal Cancer

Symptoms by clinical synopsis from OMIM:

114500

Clinical features from OMIM:

114500

Human phenotypes related to Colorectal Cancer:

32
id Description HPO Frequency HPO Source Accession
1 renal cell carcinoma 32 HP:0005584
2 neoplasm of the stomach 32 HP:0006753
3 transitional cell carcinoma of the bladder 32 HP:0006740
4 uterine leiomyosarcoma 32 HP:0002891
5 hereditary nonpolyposis colorectal carcinoma 32 HP:0006716

UMLS symptoms related to Colorectal Cancer:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Colorectal Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.03 EP300
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.03 EP300
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.03 PTPN12
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 10.03 NRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 10.03 EP300
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 10.03 NRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 10.03 NRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.03 EP300
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.03 APC BRAF EP300 NRAS PTPN12
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 10.03 PTPN12
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.03 PTPN12
12 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.43 BAX BRAF EP300 MLH3 RAD54B TP53
13 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 PDGFRL RAD54B TP53 BAX DCC
14 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 PDGFRL RAD54B TP53 BAX BRAF CCND1

MGI Mouse Phenotypes related to Colorectal Cancer:

44 (show all 26)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.5 FLCN NRAS PIK3CA RAD54B TP53 APC
2 growth/size/body region MP:0005378 10.47 BRAF CCND1 CTNNB1 DLC1 EP300 FGFR3
3 hematopoietic system MP:0005397 10.45 FLCN NRAS PTPN12 PTPRJ RAD54B TP53
4 cardiovascular system MP:0005385 10.44 EP300 FLCN NRAS PIK3CA PTPN12 PTPRJ
5 mortality/aging MP:0010768 10.44 NRAS PIK3CA PTPN12 PTPRJ RAD54B APC
6 homeostasis/metabolism MP:0005376 10.41 PIK3CA PTPRJ RAD54B TP53 APC BAX
7 immune system MP:0005387 10.4 APC BAX BRAF CCND1 CTNNB1 DCC
8 embryo MP:0005380 10.38 APC AXIN2 BRAF CTNNB1 DLC1 EP300
9 endocrine/exocrine gland MP:0005379 10.34 CTNNB1 EP300 MLH3 NRAS APC AXIN2
10 craniofacial MP:0005382 10.32 APC AXIN2 BRAF CCND1 CTNNB1 DLC1
11 neoplasm MP:0002006 10.29 APC BAX BRAF CCND1 CTNNB1 DCC
12 nervous system MP:0003631 10.27 APC AXIN2 BAX BRAF CCND1 CTNNB1
13 digestive/alimentary MP:0005381 10.26 APC BRAF CCND1 CTNNB1 DCC EP300
14 normal MP:0002873 10.18 APC AXIN2 BRAF CCND1 CTNNB1 DLC1
15 integument MP:0010771 10.15 CCND1 CTNNB1 FGFR3 APC BRAF NRAS
16 muscle MP:0005369 10.1 APC BAX BRAF CTNNB1 EP300 PIK3CA
17 no phenotypic analysis MP:0003012 10.09 APC AXIN2 CTNNB1 FGFR3 NRAS PIK3CA
18 limbs/digits/tail MP:0005371 10.08 BAX CTNNB1 FGFR3 NRAS TP53 APC
19 liver/biliary system MP:0005370 10.07 APC BRAF CTNNB1 NRAS PTPN12 PTPRJ
20 hearing/vestibular/ear MP:0005377 10.06 APC BAX BRAF CTNNB1 FGFR3 TP53
21 reproductive system MP:0005389 10 APC AXIN2 BAX BRAF CCND1 CTNNB1
22 renal/urinary system MP:0005367 9.92 APC BAX BRAF CTNNB1 EP300 FGFR3
23 pigmentation MP:0001186 9.85 APC BRAF CTNNB1 DCC NRAS TP53
24 respiratory system MP:0005388 9.81 BAX BRAF CCND1 CTNNB1 DCC EP300
25 skeleton MP:0005390 9.61 APC AXIN2 BAX BRAF CCND1 CTNNB1
26 vision/eye MP:0005391 9.4 APC AXIN2 BAX BRAF CCND1 CTNNB1

Drugs & Therapeutics for Colorectal Cancer

FDA approved drugs:

(show all 12)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Avastin 17 46 BEVACIZUMAB Genentech Approved July 2009
2
Campostar 17 46 IRINOTECAN HYDROCHLORIDE Pharmacia & Upjohn Approved June 1996
3
CEA-Scan 17 Immunomedics Approved April 1996
4
Eloxatin 17 46 OXALIPLATIN Sanofi-aventis Approved August 2002
5
Erbitux 17 46 CETUXIMAB Imclone, Bristol-Myers Squibb Approved February 2004
6
Fusilev 17 LEVOLEUCOVORIN CALCIUM Spectrum Pharmaceuticals Approved March of 2008
7
Iressa 17 46 GEFITINIB AstraZeneca Approved May 2003
8
Stivarga 17 46 REGORAFENIB Bayer/ Bayer HealthCare Pharmaceuticals Approved February 2013/ Approved September 2012
9
Sutent 17 46 SUNITINIB MALATE Pfizer Approved May 2011/ Approved January 2006
10
Vectibix 17 46 PANITUMUMAB Amgen Approved September 2006
11
Xeloda 17 46 CAPECITABINE Roche Approved April 1998/ Approved May 2001
12
Zaltrap 17 46 ZIV-AFLIBERCEPT Sanofi-aventis Approved August 2012

Drugs for Colorectal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 940)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Erythromycin Approved, Vet_approved Phase 4,Phase 2 114-07-8 12560
2
Bisacodyl Approved Phase 4,Phase 3,Phase 2 603-50-9
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 1 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-24-8 5755
5
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
6
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
7 Tegafur Approved Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
9
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
10
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
11
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
12
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
13
Iron Approved Phase 4,Phase 3,Phase 2,Early Phase 1 7439-89-6 23925
14
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
15
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 137-58-6 3676
16
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
17
Capecitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 154361-50-9 60953
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 437-38-7 3345
19
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
20
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
21
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
22
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
23
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
24
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 2078-54-8 4943
25
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
26
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
27
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
28
Hydromorphone Approved, Illicit Phase 4,Phase 2 466-99-9 5284570
29
Ketorolac Approved Phase 4,Phase 2 74103-06-3, 66635-83-4 3826
30
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
31
Epirubicin Approved Phase 4,Phase 3,Phase 1,Phase 2 56420-45-2 41867
32
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
33
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
35
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
36
Magnesium oxide Approved Phase 4,Phase 2 1309-48-4 14792
37
Darbepoetin alfa Approved, Investigational Phase 4 11096-26-7, 209810-58-2
38
Sodium sulfate Approved, Vet_approved Phase 4,Phase 2,Phase 1 7757-82-6
39
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
40
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
41
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
42
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
43
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
44
Ranibizumab Approved Phase 4,Phase 3 347396-82-1 459903
45
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
46
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
47
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2 83150-76-9 383414 6400441
48
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
49
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
50
Sulfamethoxazole Approved Phase 4 723-46-6 5329

Interventional clinical trials:

(show top 50) (show all 5189)
id Name Status NCT ID Phase
1 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
2 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4
3 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4
4 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4
5 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
6 Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma Unknown status NCT00307606 Phase 4
7 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4
8 Efficacy Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia Unknown status NCT01767870 Phase 4
9 Does the Hyoscine N-Butylbromide Administered During Colonoscopy Increase the Adenoma Detection Rate? Unknown status NCT01609855 Phase 4
10 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4
11 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4
12 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4
13 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
14 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4
15 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4
16 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4
17 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4
18 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
19 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4
20 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4
21 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4
22 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4
23 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4
24 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4
25 Prevalence of Colon Cancer in Pyogenic Liver Abscess Completed NCT02032914 Phase 4
26 Clinical Evaluation of Narrow Band Imaging Colonoscope Completed NCT00628147 Phase 4
27 Endo-Laparoscopic Approach Versus Conventional Open Surgery in Obstructing Left-sided Colon Cancer: RCT Completed NCT00654212 Phase 4
28 MASCOT : Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4
29 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4
30 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
31 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4
32 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4
33 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4
34 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4
35 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4
36 Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population Completed NCT01557101 Phase 4
37 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4
38 Improving Complete Endoscopic Mucosal Resection (EMR) of Colorectal Neoplasia Completed NCT01471756 Phase 4
39 Inflammatory Response in Laparoscopic and Open Colectomy Completed NCT00942461 Phase 4
40 Study of Biomarkers in Patients Undergoing Chemotherapy for Metastatic Colorectal Cancer Completed NCT00559676 Phase 4
41 The Effect of Darbepoetin Upon Rehabilitation for Colorectal Cancer Surgery Completed NCT00122720 Phase 4
42 Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection Completed NCT01887158 Phase 4
43 Optimisation and Performance of Reduced Preparation CT Colography Completed NCT00212433 Phase 4
44 Magnetic Resonance (MR) Colonography With Fecal Tagging Completed NCT00114842 Phase 4
45 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4
46 Carotene and Retinol Efficacy Trial Completed NCT00712647 Phase 4
47 Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid. Completed NCT02073552 Phase 4
48 Preoperative Assessment for Synchronous Carcinoma or Polyps With Magnetic Resonance (MR) Colonography Completed NCT00300547 Phase 4
49 Comparative Study of Postprocessing Imaging Systems for Diminutive Colonic Polyps Completed NCT01133041 Phase 4
50 CHOICE: Communicating Health Options Through Information and Cancer Education Completed NCT00134589 Phase 4

Search NIH Clinical Center for Colorectal Cancer

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Colorectal Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Colorectal Cancer:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Colorectal Cancer:
Tumor infiltrating lymphocytes PMIDs: 24329789 19342963 23904171 21498393 22996367 19304471 22555974 15800326 23650429 21325070 24218514 8170938 12242449

Cochrane evidence based reviews: colonic neoplasms

Genetic Tests for Colorectal Cancer

Genetic tests related to Colorectal Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Colon 29
2 Colon Cancer 29
3 Colorectal Cancer 29 24 TP53
4 Neoplasm of the Colon 29
5 Colon Cancer (apc I1307k Related) 24 APC
6 Colorectal Cancer, Somatic 24 CTNNB1 DCC FGFR3 EP300 BRAF FLCN NRAS

Anatomical Context for Colorectal Cancer

MalaCards organs/tissues related to Colorectal Cancer:

39
Colon, Liver, Endothelial, Testes, Breast, Lymph Node, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Colorectal Cancer:

18
The Rectum, The Colon

Publications for Colorectal Cancer

Articles related to Colorectal Cancer:

(show top 50) (show all 10291)
id Title Authors Year
1
MicroRNAs: Potential Candidates for Diagnosis and Treatment of Colorectal Cancer. ( 28092102 )
2017
2
KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells. ( 28011472 )
2017
3
Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines. ( 28345468 )
2017
4
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. ( 28423402 )
2017
5
53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway. ( 27838786 )
2017
6
USP39 promotes colorectal cancer growth and metastasis through the Wnt/I^-catenin pathway. ( 28259917 )
2017
7
WNT5A Promoter Methylation Is Associated with Better Responses and Longer Progression-Free Survival in Colorectal Cancer Patients Treated with 5-Fluorouracil-Based Chemotherapy. ( 28051879 )
2017
8
The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue. ( 28347238 )
2017
9
Simvastatin inhibits tumor angiogenesis in HER2-overexpressing human colorectal cancer. ( 27887848 )
2017
10
The incidence of post-colonoscopy colorectal cancer: a retrospective long-term cohort study using a colonoscopy database. ( 28091843 )
2017
11
The lncRNA H19 Promotes Cell Proliferation by Competitively Binding to miR-200a and Derepressing I^-Catenin Expression in Colorectal Cancer. ( 28164117 )
2017
12
Adiponectin and colorectal cancer. ( 27061803 )
2017
13
Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer. ( 28124380 )
2017
14
MicroRNA-196b-5p regulates colorectal cancer cell migration and metastases through interaction of HOXB7 and GALNT5. ( 28533224 )
2017
15
Association of Osteopontin Gene Polymorphisms with Colorectal Cancer. ( 28095066 )
2017
16
Serum microRNA-135a-5p as an auxiliary diagnostic biomarker for colorectal cancer. ( 27126269 )
2017
17
CpG island methylator phenotype is an independent predictor of survival after curative resection for colorectal cancer: A prospective cohort study. ( 28087988 )
2017
18
Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer. ( 28103507 )
2017
19
Clinicopathologic significance of TRAP1 expression in colorectal cancer: a large scale study of human colorectal adenocarcinoma tissues. ( 28088229 )
2017
20
Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery. ( 28165374 )
2017
21
Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer. ( 28000878 )
2017
22
Randomized clinical trial of preoperative oral versus intravenous iron in anaemic patients with colorectal cancer. ( 28092401 )
2017
23
JianPi JieDu Recipe Inhibits Epithelial-to-Mesenchymal Transition in Colorectal Cancer through TGF-I^/Smad Mediated Snail/E-Cadherin Expression. ( 28299321 )
2017
24
The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression. ( 28381186 )
2017
25
Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa. ( 28533824 )
2017
26
Long non-coding RNA FBXL19-AS1 plays oncogenic role in colorectal cancer by sponging miR-203. ( 28479250 )
2017
27
The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. ( 27875818 )
2017
28
USP9X, a Putative Tumor Suppressor Gene, Exhibits Frameshift Mutations in Colorectal Cancers. ( 27770309 )
2017
29
Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer. ( 28218782 )
2017
30
Tailored telephone counselling to increase participation of underusers in a population-based colorectal cancer-screening programme with faecal occult blood test: A randomized controlled trial. ( 28089385 )
2017
31
Serum Cyr61 as a potential biomarker for diagnosis of colorectal cancer. ( 27743169 )
2017
32
Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies. ( 28086228 )
2017
33
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. ( 27741356 )
2017
34
A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer). ( 28460341 )
2017
35
Assessing the clinical utility of Wnt pathway markers in colorectal cancer. ( 28534366 )
2017
36
TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway. ( 28534983 )
2017
37
ERCC1 and ERCC2 as predictive biomarkers to oxaliplatin-based chemotherapy in colorectal cancer patients from Egypt. ( 28088319 )
2017
38
Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial. ( 27681944 )
2017
39
T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer. ( 28178623 )
2017
40
The association of low penetrance genetic risk modifiers with colorectal cancer in lynch syndrome patients: a systematic review and meta-analysis. ( 28508326 )
2017
41
Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity. ( 27571988 )
2017
42
Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer. ( 28000854 )
2017
43
Energy restriction at young age, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk in the Netherlands Cohort Study. ( 27649841 )
2017
44
Overexpression of miR-10b in colorectal cancer patients: Correlation with TWIST-1 and E-cadherin expression. ( 28345456 )
2017
45
Synergistically Anti-metastatic Effect of 5-Flourouracil on Colorectal Cancer Cells via Calcium-mediated Focal Adhesion Kinase Proteolysis. ( 28011480 )
2017
46
The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer. ( 28035578 )
2017
47
SMAD-4 gene expression in human colorectal cancer: Comparison with some clinical and pathological parameters. ( 27914767 )
2017
48
ZNF148 modulates TOP2A expression and cell proliferation via ceRNA regulatory mechanism in colorectal cancer. ( 28072746 )
2017
49
Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells. ( 28347227 )
2017
50
MiR-26a downregulates retinoblastoma in colorectal cancer. ( 28443472 )
2017