MCID: CLR023
MIFTS: 73

Colorectal Cancer malady

Genetic diseases, Cancer diseases, Rare diseases categories
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Summaries for Colorectal Cancer

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34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

MalaCards: Colorectal Cancer, also known as colorectal carcinoma, is related to lynch syndrome and adenoma. An important gene associated with Colorectal Cancer is CCND1 (cyclin D1), and among its related pathways are Colorectal Cancer Metastasis and Pathways in cancer. The compounds vegf and serine have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and colon, and related mouse phenotypes are tumorigenesis and cellular.

Wikipedia:65 Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is when cancer develops in... more...

Description from OMIM:47 114500

Aliases & Classifications for Colorectal Cancer

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8Disease Ontology, 65Wikipedia, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases


Aliases & Descriptions:

colorectal cancer 8 65 47 10 45 34 62
colorectal carcinoma 45 62


External Ids:

Disease Ontology8 DOID:9256
MeSH35 D015179
OMIM47 114500

Related Diseases for Colorectal Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Colorectal Cancer family:

Familial Colorectal Cancer Colorectal Cancer 6
Colorectal Cancer 2 Colorectal Cancer 1
Colorectal Cancer 5 Colorectal Cancer 7
Colorectal Cancer 12 Colorectal Cancer 8
Colorectal Cancer 4 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1lynch syndrome31.8PMS2, MSH6
2adenoma31.4PPARD, TLR4, PMS2, TP53, BRAF, MSH6
3colon cancer31.4PPARD, TP53, BRAF, MSH6, CCND1, CTNNB1
4breast cancer31.2PPARD, SMAD7, PMS2, PMS1, TP53, DCC
5familial adenomatous polyposis31.2CTNNB1, AXIN2, PLA2G2A, CCND1, PPARD, PMS2
6adenocarcinoma31.0SMAD7, PMS2, TP53, BRAF, MSH6, CCND1
7ovarian cancer30.9PMS2, TP53, BRAF, MSH6, CCND1, CTNNB1
8melanoma30.9PPARD, TLR4, PMS2, PMS1, TP53, BRAF
9inflammatory bowel disease30.8TLR2, TLR4, SMAD7, PLA2G2A
10lung cancer30.8TLR4, SMAD7, TP53, BRAF, CCND1
11retinoblastoma30.6CCND1, TP53, PMS1, SMAD7
12muir-torre syndrome30.6MSH6
13colorectal cancer, somatic30.6MLH3, DCC, PDGFRL, CTNNB1, AXIN2
14endometrial carcinoma30.5CTNNB1, BRAF, TP53
15turcot syndrome30.5PMS2, MSH6
16prostate cancer30.5PPARD, SMAD7, PMS2, PMS1, TP53, MSH6
17hepatocellular carcinoma30.5PPARD, TLR2, TLR4, SMAD7, TP53, CCND1
18pancreatic cancer30.5SMAD7, TP53, BRAF, CCND1, PLA2G2A, CTNNB1
19lung adenocarcinoma30.4TP53, BRAF, CCND1, CTNNB1
20gastritis30.3TP53, TLR4, TLR2
21stomach cancer30.2SMAD7, TP53, BRAF, CCND1, CTNNB1
22glioblastoma multiforme30.1TLR4, PMS2, TP53, CCND1
23familial colorectal cancer11.0
24endotheliitis11.0
25breast and colorectal cancer11.0
26hepatitis10.9
27ulcerative colitis10.7
28hypoxia10.7
29peritonitis10.6
30prostatitis10.6
31colorectal adenoma10.6
32pancreatitis10.5
33obesity10.5
34mutyh-associated polyposis10.4
35colorectal cancer, hereditary nonpolyposis, type 110.4
36crohn's disease10.3
37sclerosing cholangitis10.3
38cholangitis10.3
39esophagitis10.3
40leukemia10.3
41neuropathy10.3
42primary sclerosing cholangitis10.3
435-fluorouracil toxicity10.3
44small bowel adenocarcinoma10.3
45neutropenia10.3
46peripheral neuropathy10.3
47oligodontia-colorectal cancer syndrome10.3
48colorectal cancer 110.3
49blindness10.3
50hyperplastic polyposis syndrome10.3

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Symptoms for Colorectal Cancer

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47OMIM
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Symptoms by clinical synopsis from OMIM:

114500

Clinical features from OMIM:

114500

Drugs & Therapeutics for Colorectal Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Genetic Tests for Colorectal Cancer

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Anatomical Context for Colorectal Cancer

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33MalaCards
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MalaCards organs/tissues related to Colorectal Cancer:

33
Liver, Breast, Colon, Endothelial, Testes, Lymph node, Lung, T cells, Prostate, Bone, Brain, Monocytes, Bone marrow, Myeloid, Skin, Testis, Whole blood, Thyroid, Pancreas, Fetal liver, Eye, B cells, Small intestine, Nk cells, Heart, Placenta, Smooth muscle, Pituitary

Animal Models for Colorectal Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Colorectal Cancer:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.4CTNNB1, PPARD, TLR2, TLR4, PMS2, PMS1
2MP:000538411.4PMS2, SMAD7, TLR4, TLR2, PPARD, TP53
3MP:001076811.3PMS2, SMAD7, TLR4, TLR2, PPARD, TP53
4MP:000538711.2PPARD, TLR2, TLR4, SMAD7, PMS2, TP53
5MP:001077111.2PPARD, TLR2, TLR4, SMAD7, TP53, POLE
6MP:000537611.2SMAD7, TLR4, TLR2, PPARD, PMS2, TP53
7MP:000538911.2PPARD, MLH3, TLR4, SMAD7, PMS2, TP53
8MP:000538111.2PPARD, TLR2, TLR4, PMS2, TP53, DCC
9MP:000538511.1TLR2, TLR4, SMAD7, TP53, BRAF, CCND1
10MP:000537911.1MLH3, TLR2, PMS2, TP53, BRAF, CCND1
11MP:000539711.1TLR2, TLR4, SMAD7, PMS2, TP53, POLE
12MP:000538611.0PPARD, TLR2, TLR4, SMAD7, TP53, DCC
13MP:000538811.0TLR2, TLR4, TP53, DCC, BRAF, CCND1
14MP:000118610.9TLR4, TP53, DCC, BRAF, CTNNB1
15MP:000363110.9PPARD, TLR2, TLR4, TP53, DCC, BRAF
16MP:000539110.9TLR4, TP53, DCC, BRAF, CCND1, CTNNB1
17MP:000536910.9TLR2, TLR4, SMAD7, TP53, BRAF, MT-CO1
18MP:000539010.8TLR2, TLR4, TP53, BRAF, CCND1, CTNNB1
19MP:000537510.7BRAF, TP53, TLR4, TLR2, PPARD
20MP:000537010.6PPARD, TLR2, TLR4, TP53, BRAF, CTNNB1
21MP:000537810.6PPARD, TLR2, TLR4, SMAD7, TP53, BRAF

Publications for Colorectal Cancer

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52PubMed
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Articles related to Colorectal Cancer:

(show top 50)    (show all 7455)
idTitleAuthorsYear
1
E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells. (24369055)
2013
2
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
3
Metachronous colorectal cancer: A competing risks analysis with consideration for a stratified approach to surveillance colonoscopy. (24272767)
2013
4
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing. (24284403)
2013
5
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry. (23745025)
2013
6
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
7
Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. (23226332)
2012
8
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. (23033949)
2012
9
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer. (22699826)
2012
10
Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer. (22351690)
2012
11
Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression. (21806965)
2011
12
Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome. (20584785)
2010
13
BRAF mutation predicts resistance to anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer. (20514492)
2010
14
High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. (19856313)
2010
15
A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. (19616522)
2009
16
Individualized therapies in colorectal cancer: KRAS as a marker for response to EGFR-targeted therapy. (19386128)
2009
17
P53 and EGFR expression in colorectal cancer: a reappraisal of 'old' tissue markers in patients with long follow-up. (19331236)
2009
18
High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. (19418581)
2009
19
Invasion front-specific overexpression of tissue inhibitor of metalloproteinase-1 in liver metastases from colorectal cancer. (18630499)
2008
20
An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. (17785764)
2008
21
KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors. (19378369)
2008
22
Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. (18419600)
2008
23
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (18381954)
2008
24
Galectin-3 expression in colorectal cancer: relation to invasion and metastasis. (17695516)
2007
25
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
26
Genetic testing in colorectal cancer: who, when, how and why. (17392593)
2007
27
Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer. (17883421)
2007
28
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. (16804544)
2006
29
Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples. (15956025)
2006
30
Expression of maspin in colorectal cancer. (17203770)
2006
31
Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. (16491830)
2005
32
Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. (15041737)
2004
33
High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. (15534108)
2004
34
The role of new agents in the treatment of colorectal cancer. (15031593)
2004
35
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule. (15550581)
2004
36
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. (15355920)
2004
37
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
38
Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. (14968945)
2003
39
Significance of transforming growth factor beta1 as a new tumor marker for colorectal cancer. (11802214)
2002
40
Enhanced 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in human colorectal cancer not expressing low density lipoprotein receptor. (10226581)
1999
41
Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients. (10206298)
1999
42
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. (10490837)
1999
43
Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. (9683794)
1998
44
Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. (9615749)
1998
45
Soluble CD44 and CD44v6 serum levels in patients with colorectal cancer are independent of tumor stage and tissue expression of CD44v6. (9625129)
1998
46
Beta-catenin mutations in cell lines established from human colorectal cancers. (9294210)
1997
47
Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines. (8712692)
1996
48
APC mutation analysis in sporadic colorectal cancer]. (9387290)
1996
49
Colonoscopy in relation to the evolving genetics of familial colorectal cancer. (7601034)
1995
50
Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. (7874129)
1994

Variations for Colorectal Cancer

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Clinvar genetic disease variations for Colorectal Cancer:

1
id Gene Name Type Significance SNP ID Assembly Location
1CHEK2NM_007194.3(CHEK2): c.470T> C (p.Ile157Thr)single nucleotide variantLikely pathogenic, Pathogenic, risk factorrs17879961GRCh37Chr 22, 29121087: 29121087

Expression for genes affiliated with Colorectal Cancer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colorectal Cancer

Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 54R&D Systems, 61Tocris Bioscience, 57SinoBiological, 51PharmGKB, 12EMD Millipore
See all sources

Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AXIN2, TLR2, TLR4, TP53, DCC, BRAF
210.8PPARD, TP53, DCC, BRAF, MSH6, CCND1
3
Show member pathways
Signal transduction PTEN pathway60
10.8PPARD, TP53, DCC, BRAF, MSH6, CCND1
410.7TLR2, TLR4, TP53, BRAF, CCND1, CTNNB1
510.7SMAD7, TP53, BRAF, MSH6, CCND1, CTNNB1
6
Show member pathways
10.7CCND1, BRAF, TP53, TLR4, TLR2
7
Show member pathways
Signaling Pathways in Glioblastoma38
10.7TP53, BRAF, MSH6, CCND1, CTNNB1
8
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
10.7CTNNB1, CCND1, POLE, DCC, TP53
910.7SMAD7, TP53, CCND1, CTNNB1, AXIN2
10
Show member pathways
Wnt Signaling Pathway NetPath38
10.7AXIN2, CTNNB1, CCND1, TP53, PPARD
11
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
10.7AXIN2, CTNNB1, CCND1, TP53, PPARD
12
Show member pathways
10.7MLH3, PMS2, PMS1, POLE, MSH6
1310.7TLR2, TLR4, TP53, CCND1
14
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
10.7TLR2, TLR4, TP53, CCND1
15
Show member pathways
10.7CCND1, TP53, TLR4, TLR2
1610.7TLR4, TP53, CCND1, PLA2G2A
17
Show member pathways
10.7BRAF, TP53, TLR4, TLR2
1810.7TP53, BRAF, CCND1, CTNNB1
1910.7CTNNB1, CCND1, BRAF, TP53
2010.7TP53, DCC, CCND1, CTNNB1
2110.7CTNNB1, CCND1, POLE, TP53
2210.7PPARD, TP53, CCND1, CTNNB1
23
Show member pathways
10.6TP53, POLE, MSH6, CCND1
2410.6TP53, POLE, MSH6, CCND1
2510.6SMAD7, CCND1, CTNNB1, AXIN2
26
Show member pathways
10.6TP53, TLR4, TLR2
27
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
10.6CCND1, BRAF, TP53
28
Show member pathways
10.6TP53, BRAF, CCND1
2910.6CTNNB1, CCND1, TP53
30
Show member pathways
10.6BRAF, TLR4, TLR2
31
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
10.6TLR4, BRAF, CTNNB1
3210.6CTNNB1, BRAF, TLR4
33
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
10.6CCND1, MSH6, TP53
34
Show member pathways
10.6TP53, POLE, CCND1
3510.6CCND1, CTNNB1, AXIN2
36
Show member pathways
10.6AXIN2, CTNNB1, TP53
3710.6CTNNB1, CCND1, PPARD

Compounds for genes affiliated with Colorectal Cancer

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Sources:
45Novoseek, 24HMDB, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 29IUPHAR
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Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1vegf4511.3PPARD, TLR2, TLR4, SMAD7, TP53, BRAF
2serine4511.3TP53, CCND1, PLA2G2A, MSH6, CTNNB1, BRAF
3tyrosine4511.3SMAD7, CTNNB1, PDGFRL, BRAF, TLR4, TLR2
4retinoic acid45 2412.3TP53, TLR4, PPARD, CTNNB1, PLA2G2A, CCND1
5sb 20358045 6112.2TLR4, SMAD7, BRAF, CCND1, CTNNB1, TLR2
6cisplatin45 51 61 1114.2BRAF, TLR4, SMAD7, CCND1, MSH6, TP53
7cycloheximide4511.2SMAD7, TLR2, TLR4, TP53, PLA2G2A, CCND1
8crcs4511.2CTNNB1, MSH6, BRAF, TP53, PMS2, CCND1
9n acetylcysteine4511.2TLR4, SMAD7, CCND1, TP53, PLA2G2A, CTNNB1
10ly2940024511.2CCND1, CTNNB1, PLA2G2A, BRAF, TLR4, TP53
11paraffin4511.2CCND1, MSH6, BRAF, TP53, PMS2, CTNNB1
12fatty acid4511.2PPARD, BRAF, TLR2, MT-CO1, PLA2G2A, CTNNB1
13palmitate4511.1TLR2, TLR4, PLA2G2A, CTNNB1, PPARD
14paclitaxel45 51 1113.1CCND1, CTNNB1, BRAF, TP53, TLR4
15oligonucleotide4511.1TP53, PPARD, BRAF, CTNNB1, SMAD7, CCND1
16docosahexaenoic acid45 29 2413.1PPARD, TLR4, TLR2, PLA2G2A
17wortmannin4511.1BRAF, TLR4, TLR2, CTNNB1, CCND1
18dexamethasone45 51 29 1114.1TLR2, CTNNB1, PLA2G2A, SMAD7, TLR4, PPARD
19pd 98,0594511.1CCND1, SMAD7, CTNNB1, BRAF, TLR2
20sulindac45 1112.1CCND1, CTNNB1, TP53, PPARD
21actinomycin d4511.1TLR4, TLR2, SMAD7, TP53, PLA2G2A
22phosphatidylinositol4511.1CCND1, CTNNB1, PPARD, TLR2, TLR4, BRAF
23geldanamycin45 51 61 1114.1TP53, CTNNB1, BRAF, CCND1
24gf 109203x45 6112.1PLA2G2A, CTNNB1, TLR2, CCND1
25exisulind4511.0CTNNB1, CCND1, PPARD
26tgf beta14511.0CTNNB1, TLR4, CCND1, SMAD7
27sulindac sulfide4511.0CCND1, TP53, PPARD
28pge24511.0CTNNB1, PLA2G2A, TLR4, TLR2, PPARD
29o6-methylguanine4511.0MSH6, BRAF, TP53
30cetuximab45 51 1113.0CCND1, BRAF, CTNNB1
31pidotimod4510.9AXIN2, CTNNB1
32indole-3-carbinol4510.9CTNNB1, CCND1, TP53
33depsipeptide4510.9TP53, BRAF, CCND1
34arabinogalactan4510.9TLR4, TLR2
35sb-2167634510.9CTNNB1, CCND1
36aspirin45 51 29 2413.9PLA2G2A, CTNNB1, PPARD, TLR4
37roscovitine4510.9CTNNB1, TP53, CCND1
38retinoid4510.9TP53, PPARD, CTNNB1, CCND1
39samp4510.9AXIN2, CTNNB1
40chlorophyllin4510.8CCND1, CTNNB1
41mhs-24510.8PMS1, PMS2
42diaminopimelic acid4510.8TLR4, TLR2
43loxoribine45 2911.7TLR2, TLR4
44atp45 2911.7PPARD, MT-CO1, BRAF, CTNNB1, TLR4, TLR2
45poly(i:c)6110.7TLR4, TLR2
46pam3csk46110.7TLR4, TLR2
47pam2csk46110.6TLR4, TLR2
48c2ceramide4510.6TP53, PLA2G2A, TLR4
49matrigel4510.6SMAD7, CCND1, CTNNB1, BRAF
50glucose4510.4PPARD, TLR4, TLR2, SMAD7, BRAF, MT-CO1

GO Terms for genes affiliated with Colorectal Cancer

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16Gene Ontology
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Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.1PPARD, MLH3, SMAD7, PMS2, PMS1, TP53
2cytoplasmGO:00573710.9TLR4, SMAD7, PMS2, TP53, POLE, MSH6
3mismatch repair complexGO:03230010.8PMS1, PMS2, MLH3
4nucleoplasmGO:00565410.7PPARD, SMAD7, TP53, POLE, CCND1, CTNNB1
5MutLalpha complexGO:03238910.7PMS2, PMS1
6catenin complexGO:01634210.6SMAD7, CTNNB1
7plasma membraneGO:00588610.6TLR2, TLR4, SMAD7, DCC, POLE, BRAF
8beta-catenin destruction complexGO:03087710.5AXIN2, CTNNB1

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00012211.0PPARD, SMAD7, TP53, CCND1, CTNNB1
2mismatch repairGO:00629811.0MSH6, PMS1, PMS2, MLH3
3reciprocal meiotic recombinationGO:00713111.0MLH3, PMS2, PMS1, MSH6
4ATP catabolic processGO:00620011.0MLH3, PMS2, PMS1, MSH6
5positive regulation of inflammatory responseGO:05072911.0PLA2G2A, TLR4, TLR2
6response to drugGO:04249311.0PMS2, PMS1, CCND1, CTNNB1
7regulation of centromeric sister chromatid cohesionGO:07060210.9AXIN2, CTNNB1
8maintenance of DNA repeat elementsGO:04357010.9MSH6, AXIN2
9somatic recombination of immunoglobulin gene segmentsGO:01644710.9PMS2, MSH6
10cellular response to lipoteichoic acidGO:07122310.9TLR2, TLR4
11positive regulation of macrophage cytokine productionGO:06090710.9TLR2, TLR4
12positive regulation of transcription from RNA polymerase II promoterGO:04594410.9TLR2, TLR4, SMAD7, TP53, CTNNB1
13negative regulation of interleukin-17 productionGO:03270010.9TLR4, TLR2
14adherens junction assemblyGO:03433310.9SMAD7, CTNNB1
15positive regulation of tumor necrosis factor biosynthetic processGO:04253510.9TLR2, TLR4
16mitotic G1 DNA damage checkpointGO:03157110.9TP53, CCND1
17positive regulation of ERK1 and ERK2 cascadeGO:07037410.9TLR4, DCC, BRAF
18dorsal/ventral axis specificationGO:00995010.9CTNNB1, AXIN2
19I-kappaB phosphorylationGO:00725210.8TLR4, TLR2
20positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.8TLR4, TLR2
21determination of adult lifespanGO:00834010.8MSH6, TP53
22negative regulation of cell proliferationGO:00828510.8TLR2, TP53, CTNNB1, AXIN2
23somatic hypermutation of immunoglobulin genesGO:01644610.8MSH6, PMS2
24positive regulation of chemokine productionGO:03272210.7TLR4, TLR2
25positive regulation of interleukin-10 productionGO:03273310.7TLR4, TLR2
26negative regulation of osteoclast differentiationGO:04567110.6TLR4, CTNNB1
27positive regulation of NF-kappaB import into nucleusGO:04234610.6TLR2, TLR4
28positive regulation of interferon-beta productionGO:03272810.6TLR4, TLR2
29response to X-rayGO:01016510.5TP53, CCND1
30positive regulation of interleukin-8 productionGO:03275710.3TLR4, TLR2

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3PPARD, MLH3, TLR2, TLR4, SMAD7, PMS2
2MutSalpha complex bindingGO:03240710.9PMS1, PMS2, MLH3
3chromatin bindingGO:00368210.9MLH3, TP53, POLE, MSH6, CTNNB1
4I-SMAD bindingGO:07041110.9SMAD7, CTNNB1, AXIN2
5ATPase activityGO:01688710.8MLH3, PMS2, PMS1, MSH6
6mismatched DNA bindingGO:03098310.8MLH3, PMS1, MSH6
7enzyme bindingGO:01989910.8TP53, CCND1, CTNNB1, AXIN2
8lipopolysaccharide receptor activityGO:00187510.7TLR4, TLR2
9single-stranded DNA bindingGO:00369710.7PMS1, PMS2, MLH3
10protein kinase bindingGO:01990110.7TP53, CCND1, CTNNB1, AXIN2
11ubiquitin protein ligase bindingGO:03162510.6AXIN2, TP53, SMAD7
12transmembrane signaling receptor activityGO:00488810.5DCC, TLR4, TLR2
13ATP bindingGO:00552410.4MLH3, PMS2, PMS1, TP53, BRAF, MSH6

Products for genes affiliated with Colorectal Cancer

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Sources for Colorectal Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet