MCID: CLR023
MIFTS: 77

Colorectal Cancer malady

Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases categories
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Summaries for Colorectal Cancer

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MedlinePlus:33 The colon and rectum are part of the large intestine. colorectal cancer occurs when tumors form in the lining of the large intestine. it is common in both men and women. the risk of developing colorectal cancer rises after age 50. you're also more likely to get it if you have colorectal polyps, a family history of colorectal cancer, ulcerative colitis or crohn's disease, eat a diet high in fat, or smoke. symptoms of colorectal cancer include diarrhea or constipation a feeling that your bowel does not empty completely blood (either bright red or very dark) in your stool stools that are narrower than usual frequent gas pains or cramps, or feeling full or bloated weight loss with no known reason fatigue nausea or vomiting because you may not have symptoms at first, it's important to have screening tests. everyone over 50 should get screened. tests include colonoscopy and tests for blood in the stool. treatments for colorectal cancer include surgery, chemotherapy, radiation, or a combination. surgery can usually cure it when it is found early. nih: national cancer institute

MalaCards based summary: Colorectal Cancer, also known as colorectal carcinoma, is related to lynch syndrome and adenoma, and has symptoms including An important gene associated with Colorectal Cancer is CCND1 (cyclin D1), and among its related pathways are Colorectal Cancer Metastasis and Proteoglycans in cancer. The compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include the colon, the rectum and liver, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:8 A large intestine cancer that is located in the colon and/or located in the rectum.

Wikipedia:65 Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is the development of... more...

Description from OMIM:46 114500

Aliases & Classifications for Colorectal Cancer

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Colorectal Cancer, Aliases & Descriptions:

Name: Colorectal Cancer 30 8 65 46 10 44 33 62
 
Colorectal Carcinoma 44 62


Classifications:



External Ids:

Disease Ontology8 DOID:9256
OMIM46 114500
MeSH34 D015179

Related Diseases for Colorectal Cancer

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Diseases in the Colorectal Cancer family:

Familial Colorectal Cancer Colorectal Cancer 6
Colorectal Cancer 2 Colorectal Cancer 1
Colorectal Cancer 5 Colorectal Cancer 7
Colorectal Cancer 12 Colorectal Cancer 8
Colorectal Cancer 4 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11

Diseases related to Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1lynch syndrome32.6PMS2, MSH6
2adenoma32.0TLR4, PMS2, TP53, BRAF, MSH6, CCND1
3breast cancer31.9CTNNB1, CCND1, PIK3CA
4ovarian cancer31.9PIK3CA, PMS2, TP53, BRAF, MSH6, CCND1
5familial adenomatous polyposis31.9PMS2, TP53, BRAF, MSH6, CCND1, PLA2G2A
6adenocarcinoma31.8PIK3CA, PMS2, TP53, BRAF, MSH6, CCND1
7colorectal cancer, somatic31.5PIK3CA, MLH3, DCC, PDGFRL, CTNNB1
8lung cancer31.5CCND1, BRAF, TP53, TLR4, PIK3CA
9melanoma31.4PIK3CA, TLR4, PMS2, TP53, BRAF, CCND1
10endometrial carcinoma31.4CTNNB1, BRAF, TP53
11muir-torre syndrome31.4MSH6
12turcot syndrome31.4PMS2, MSH6
13lung adenocarcinoma31.3PIK3CA, TP53, BRAF, CCND1, CTNNB1
14stomach cancer31.3PIK3CA, TP53, BRAF, CCND1, CTNNB1
15cholangiocarcinoma31.2PIK3CA, TP53, BRAF
16colitis31.2TLR2, TLR4, PLA2G2A
17prostate cancer31.1PIK3CA, PMS2, TP53, MSH6, CCND1, MT-CO1
18pancreatic cancer31.1PIK3CA, TP53, BRAF, CCND1, PLA2G2A, CTNNB1
19squamous cell carcinoma of the head and neck31.0CCND1, TP53, PIK3CA
20non-small cell lung carcinoma30.9CCND1, BRAF, TP53
21glioblastoma30.8PIK3CA, TLR4, PMS2, TP53, CCND1
22gastritis30.7TLR2, TLR4, TP53
23leukemia30.7PIK3CA, TLR2, TLR4, TP53, CCND1, PLA2G2A
24liver cancer30.5PIK3CA, TLR2, TLR4, TP53, CCND1, CTNNB1
25familial colorectal cancer11.1
26breast and colorectal cancer11.0
27endotheliitis11.0
28hepatitis10.9
29colonic benign neoplasm10.8PIK3CA, TP53, BRAF, MSH6, CCND1, CTNNB1
30thyroid cancer, anaplastic10.8PIK3CA, TP53, BRAF, CTNNB1
31colon cancer10.8
32thyroid hurthle cell carcinoma10.7PIK3CA, TP53, BRAF, CCND1
33malignant glioma10.7MSH6, BRAF, TP53, PMS2, PIK3CA
34hypoxia10.7
35ulcerative colitis10.7
36papillary thyroid carcinoma10.7CTNNB1, CCND1, BRAF
37ovarian cancer, somatic10.7PIK3CA, CTNNB1
38hepatocellular carcinoma, somatic10.7PIK3CA, CTNNB1
39spitz nevus10.7BRAF
40peritonitis10.6
41prostatitis10.6
42inflammatory bowel disease10.6
43medulloblastoma10.6PIK3CA, TP53, CTNNB1
44colorectal adenoma10.6
45craniopharyngioma10.6CTNNB1
46pancreatitis10.6
47malignant mixed mullerian tumor10.6CTNNB1, TP53
48breast cancer, invasive ductal10.5TP53, CCND1
49gastric cancer10.5
50bladder carcinoma10.5CCND1, TP53, TLR2, PIK3CA

Graphical network of the top 20 diseases related to Colorectal Cancer:



Diseases related to colorectal cancer

Symptoms for Colorectal Cancer

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Symptoms by clinical synopsis from OMIM:

114500

Clinical features from OMIM:

114500

HPO human phenotypes related to Colorectal Cancer:

id Description Frequency HPO Source Accession
1 uterine leiomyosarcoma HP:0002891
2 renal cell carcinoma HP:0005584
3 hereditary nonpolyposis colorectal carcinoma HP:0006716
4 transitional cell carcinoma of the bladder HP:0006740
5 neoplasm of the stomach HP:0006753

Drugs & Therapeutics for Colorectal Cancer

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Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer

Search NIH Clinical Center for Colorectal Cancer

Genetic Tests for Colorectal Cancer

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Anatomical Context for Colorectal Cancer

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MalaCards organs/tissues related to Colorectal Cancer:

32
Liver, Colon, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Prostate, Bone, Brain, Myeloid, Bone marrow, Monocytes, Skin, Testis, Whole blood, Neutrophil, Pancreas, Thyroid, Pituitary, Eye, Heart, Smooth muscle, Small intestine, Placenta, Nk cells, B cells, Fetal liver, Appendix

FMA organs/tissues related to Colorectal Cancer:

14
The colon, The rectum

Animal Models for Colorectal Cancer or affiliated genes

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MGI Mouse Phenotypes related to Colorectal Cancer:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.5CTNNB1, PIK3CA, TLR2, TLR4, PMS2, TP53
2MP:000538411.4PMS2, TLR4, TLR2, PIK3CA, TP53, DCC
3MP:000537611.3PIK3CA, TLR2, TLR4, PMS2, TP53, BRAF
4MP:000538111.3TLR2, TLR4, PMS2, TP53, DCC, BRAF
5MP:000537911.2PIK3CA, MLH3, TLR2, PMS2, TP53, BRAF
6MP:001077111.2PIK3CA, TLR2, TLR4, TP53, BRAF, MSH6
7MP:000538911.2PIK3CA, MLH3, TLR4, PMS2, TP53, BRAF
8MP:000538711.2PIK3CA, TLR2, TLR4, PMS2, TP53, BRAF
9MP:001076811.2PIK3CA, TLR2, TLR4, PMS2, TP53, DCC
10MP:000538811.2TLR2, TLR4, TP53, DCC, BRAF, CCND1
11MP:000539111.1PIK3CA, TLR4, TP53, DCC, BRAF, CCND1
12MP:000536911.1PIK3CA, TLR2, TLR4, TP53, BRAF, MT-CO1
13MP:000538511.1PIK3CA, TLR2, TLR4, TP53, BRAF, CCND1
14MP:000118611.1TLR4, TP53, DCC, BRAF, CTNNB1
15MP:000537811.0TLR2, TLR4, TP53, BRAF, CCND1, MT-CO1
16MP:000538611.0PIK3CA, TLR2, TLR4, TP53, DCC, BRAF
17MP:000363110.9PIK3CA, TLR2, TLR4, TP53, DCC, BRAF
18MP:000537510.8PIK3CA, TLR2, TLR4, TP53, BRAF
19MP:000539010.5TLR2, TLR4, TP53, BRAF, CCND1, CTNNB1

Publications for Colorectal Cancer

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Articles related to Colorectal Cancer:

(show top 50)    (show all 7779)
idTitleAuthorsYear
1
The effect of oxoguanine glycosylase 1 rs1052133 polymorphism on colorectal cancer risk in Caucasian population. (23975367)
2014
2
E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells. (24369055)
2013
3
Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. (23797051)
2013
4
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
5
Metachronous colorectal cancer: A competing risks analysis with consideration for a stratified approach to surveillance colonoscopy. (24272767)
2013
6
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing. (24284403)
2013
7
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry. (23745025)
2013
8
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
9
Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. (23226332)
2012
10
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. (23033949)
2012
11
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer. (22699826)
2012
12
Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer. (22351690)
2012
13
Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression. (21806965)
2011
14
Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome. (20584785)
2010
15
BRAF mutation predicts resistance to anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer. (20514492)
2010
16
High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. (19856313)
2010
17
A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. (19616522)
2009
18
Individualized therapies in colorectal cancer: KRAS as a marker for response to EGFR-targeted therapy. (19386128)
2009
19
P53 and EGFR expression in colorectal cancer: a reappraisal of 'old' tissue markers in patients with long follow-up. (19331236)
2009
20
High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. (19418581)
2009
21
Invasion front-specific overexpression of tissue inhibitor of metalloproteinase-1 in liver metastases from colorectal cancer. (18630499)
2008
22
An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. (17785764)
2008
23
KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors. (19378369)
2008
24
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (18381954)
2008
25
Galectin-3 expression in colorectal cancer: relation to invasion and metastasis. (17695516)
2007
26
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
27
Genetic testing in colorectal cancer: who, when, how and why. (17392593)
2007
28
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. (16804544)
2006
29
Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples. (15956025)
2006
30
Expression of maspin in colorectal cancer. (17203770)
2006
31
Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. (16491830)
2005
32
Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. (15041737)
2004
33
High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. (15534108)
2004
34
The role of new agents in the treatment of colorectal cancer. (15031593)
2004
35
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule. (15550581)
2004
36
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. (15355920)
2004
37
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
38
Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. (14968945)
2003
39
Significance of transforming growth factor beta1 as a new tumor marker for colorectal cancer. (11802214)
2002
40
Enhanced 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in human colorectal cancer not expressing low density lipoprotein receptor. (10226581)
1999
41
Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients. (10206298)
1999
42
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. (10490837)
1999
43
Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. (9683794)
1998
44
Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. (9615749)
1998
45
Soluble CD44 and CD44v6 serum levels in patients with colorectal cancer are independent of tumor stage and tissue expression of CD44v6. (9625129)
1998
46
Beta-catenin mutations in cell lines established from human colorectal cancers. (9294210)
1997
47
Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines. (8712692)
1996
48
APC mutation analysis in sporadic colorectal cancer]. (9387290)
1996
49
Colonoscopy in relation to the evolving genetics of familial colorectal cancer. (7601034)
1995
50
Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. (7874129)
1994

Variations for Colorectal Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer:

64 (show all 17)
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052
10PIK3CAp.Arg38HisVAR_026166
11PIK3CAp.Gly106ValVAR_026168
12PIK3CAp.Cys420ArgVAR_026171
13PIK3CAp.Glu453GlnVAR_026172
14PIK3CAp.Glu542LysVAR_026173
15PIK3CAp.Glu545LysVAR_026178
16PIK3CAp.Met1043IleVAR_026190
17PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Colorectal Cancer:

6
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.974G> T (p.Gly325Val)single nucleotide variantPathogenicrs121912659GRCh37Chr 17, 7576872: 7576872
2TP53NM_000546.5(TP53): c.566C> T (p.Ala189Val)single nucleotide variantPathogenicrs121912665GRCh37Chr 17, 7578283: 7578283
3PLA2G2ANM_000300.3(PLA2G2A): c.144_145delTG (p.Cys48Trpfs)deletionPathogenicGRCh37Chr 1, 20304913: 20304914
4MT-CO2m.8009G> Asingle nucleotide variantPathogenicrs199474826GRCh37Chr MT, 8009: 8009
5MT-CO1m.6264G> Asingle nucleotide variantPathogenicrs267606882GRCh37Chr MT, 6264: 6264
6MT-CO1m.6277G> Asingle nucleotide variantPathogenicGRCh37Chr MT, 6277: 6277
7MT-CYBm.14985G> Asingle nucleotide variantPathogenicrs207459995GRCh37Chr MT, 14985: 14985
8MT-CYBm.15572T> Csingle nucleotide variantPathogenicrs207459996GRCh37Chr MT, 15572: 15572
9MT-ND4Lm.10563T> Csingle nucleotide variantPathogenicrs267606892GRCh37Chr MT, 10563: 10563

Expression for genes affiliated with Colorectal Cancer

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Expression patterns in normal tissues for genes affiliated with Colorectal Cancer

Search GEO for disease gene expression data for Colorectal Cancer.

Pathways for genes affiliated with Colorectal Cancer

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Pathways related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0CCND1, BRAF, DCC, TP53, CTNNB1, TLR4
210.9PIK3CA, TLR4, CTNNB1, CCND1, BRAF, TP53
3
Show member pathways
10.9GALNT12, PLA2G2A, MT-CO2, MT-CYB, MT-ND4L, MT-CO1
4
Show member pathways
Signal transduction PTEN pathway60
10.9BRAF, CTNNB1, CCND1, MSH6, DCC, TP53
510.9CCND1, CTNNB1, PIK3CA, MSH6, BRAF, DCC
6
Show member pathways
10.8MT-CO2, MT-ND4L, PIK3CA, MT-CO1, TP53, MT-CYB
7
Show member pathways
Signaling Pathways in Glioblastoma37
10.8BRAF, CCND1, PIK3CA, TP53, MSH6, CTNNB1
8
Show member pathways
10.8TLR2, TP53, TLR4, BRAF, CCND1
910.8TP53, CCND1, TLR4, PIK3CA, TLR2
10
Show member pathways
10.8PIK3CA, TLR4, TLR2, CCND1, TP53
11
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.8PIK3CA, TLR2, TP53, CCND1, TLR4
12
Show member pathways
10.8BRAF, PIK3CA, TLR2, TLR4, TP53
1310.8PIK3CA, TP53, CTNNB1, CCND1, DCC
1410.8CCND1, CTNNB1, TP53, BRAF, MSH6
1510.7PLA2G2A, TP53, TLR4, CCND1
1610.7TP53, BRAF, CCND1, CTNNB1
1710.7CTNNB1, TP53, CCND1, BRAF
18
Show member pathways
Alzheimers Disease37
10.7MT-CO2, TP53, MT-CYB, MT-CO1
19
Show member pathways
10.7BRAF, PIK3CA, TP53, CCND1
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.7BRAF, TP53, PIK3CA, CCND1
2110.7TP53, CTNNB1, CCND1, PIK3CA
2210.7CCND1, CTNNB1, TP53, PIK3CA
23
Show member pathways
10.7PIK3CA, CCND1, PLA2G2A, BRAF
24
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.7TP53, PIK3CA, CCND1, MSH6
25
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
10.7PIK3CA, CCND1, BRAF, CTNNB1
26
Show member pathways
10.7CTNNB1, PIK3CA, PLA2G2A, BRAF
27
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
10.7CCND1, TP53, PIK3CA
2810.7CCND1, TP53, PIK3CA
29
Show member pathways
10.7TLR4, TLR2, BRAF
30
Show member pathways
10.7TLR4, PIK3CA, TP53
3110.7TLR4, TLR2, PIK3CA
3210.7CCND1, MT-CO2, CTNNB1
3310.7MSH6, CCND1, TP53
3410.7MT-CO1, MT-CYB, MT-CO2
3510.7BRAF, PIK3CA, CCND1
36
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.7BRAF, CCND1, PIK3CA
3710.7BRAF, TLR4, CTNNB1
38
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
10.7BRAF, CTNNB1, TLR4
3910.7PIK3CA, BRAF, TP53
40
Show member pathways
10.7BRAF, TP53, PIK3CA
41
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
10.7PIK3CA, CTNNB1, CCND1
42
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.7CTNNB1, PIK3CA, CCND1
4310.7CTNNB1, CCND1, PIK3CA
4410.7CTNNB1, PLA2G2A, PIK3CA
45
Show member pathways
Development A2B receptor action via G protein alpha s60
10.7PIK3CA, CTNNB1, BRAF
46
Show member pathways
RAC1 signaling pathway37
10.7PIK3CA, CTNNB1, BRAF
47
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
10.7PIK3CA, BRAF, CTNNB1
48
Show member pathways
10.6DCC, CTNNB1, PIK3CA
49
Show member pathways
10.6MLH3, MSH6, PMS2
5010.6PIK3CA, BRAF

Compounds for genes affiliated with Colorectal Cancer

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Compounds related to Colorectal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1serine4411.5CTNNB1, PLA2G2A, MT-CYB, CCND1, MSH6, TP53
2vegf4411.4PLA2G2A, CCND1, BRAF, TP53, TLR4, TLR2
3retinoic acid44 2412.4TLR2, BRAF, PIK3CA, TLR4, TP53, CCND1
4atp44 2812.4CTNNB1, TLR2, MT-CO2, MT-CYB, MT-CO1, BRAF
5ly2940024411.3TP53, BRAF, CCND1, PLA2G2A, CTNNB1, TLR4
6cycloheximide4411.3TLR2, TLR4, CTNNB1, MT-CYB, PLA2G2A, TP53
7crcs4411.3PIK3CA, PMS2, CTNNB1, CCND1, MSH6, BRAF
8cisplatin44 50 61 1114.3CTNNB1, PIK3CA, TLR4, CCND1, MSH6, BRAF
9h2o24411.3CTNNB1, PLA2G2A, PIK3CA, TLR2, MT-CYB, TLR4
10tyrosine4411.3PIK3CA, PDGFRL, TLR2, TLR4, BRAF, MSH6
11sb 20358044 6112.3CCND1, CTNNB1, TLR2, TLR4, TP53, BRAF
12paclitaxel44 50 1113.3CCND1, BRAF, TP53, CTNNB1, TLR4, PIK3CA
13wortmannin4411.3TLR4, CCND1, CTNNB1, TLR2, PIK3CA, BRAF
14paraffin4411.2PMS2, CCND1, MSH6, BRAF, TP53, CTNNB1
15n acetylcysteine4411.2CTNNB1, PLA2G2A, CCND1, TP53, TLR4
16phospholipid4411.2CTNNB1, PLA2G2A, MT-CYB, TLR4, TLR2
17histamine44 28 2413.2CTNNB1, PLA2G2A, TLR4, TLR2, PIK3CA
18pd 98,0594411.2PIK3CA, CTNNB1, TLR2, CCND1, BRAF
19pdtc4411.1TP53, PIK3CA, TLR4, PLA2G2A
20doxorubicin44 50 1113.1TP53, MSH6, CCND1, CTNNB1, PIK3CA
21actinomycin d4411.1TLR4, TP53, PLA2G2A, TLR2, PIK3CA
22adpribose4411.1TP53, PIK3CA, CTNNB1, CCND1
23geldanamycin44 50 61 1114.1CCND1, CTNNB1, BRAF, TP53
24palmitate4411.1PLA2G2A, TLR4, CTNNB1, TLR2
25phosphoinositide4411.1CTNNB1, CCND1, BRAF, TLR2, PIK3CA
26gf 109203x44 6112.1CCND1, TLR2, CTNNB1, PLA2G2A
27arginine4411.1PIK3CA, TP53, PLA2G2A, TLR2, CTNNB1, BRAF
28resveratrol44 61 24 1114.1CCND1, TP53, PIK3CA, CTNNB1
29genistein44 28 61 2 24 1116.1CCND1, TLR4, PIK3CA, CTNNB1, PLA2G2A
30phosphatidylinositol4411.1BRAF, TLR4, CTNNB1, PIK3CA, CCND1, TLR2
31egcg4411.1CCND1, TP53, PIK3CA, CTNNB1
32rofecoxib44 50 28 1114.1CTNNB1, MT-CO2, CCND1
33quercetin44 61 24 1114.0PIK3CA, CCND1, PLA2G2A, CTNNB1
34nadph44 2412.0PLA2G2A, MT-CYB, TLR4, TLR2, PIK3CA
35docosahexaenoic acid44 28 2413.0PLA2G2A, TLR2, TLR4
36o6-methylguanine4411.0MSH6, TP53, BRAF
37imatinib44 50 1113.0BRAF, CTNNB1, PIK3CA, CCND1
38cetuximab44 50 1113.0BRAF, CCND1, CTNNB1
39pge24411.0CTNNB1, TLR4, TLR2, MT-CO2, PLA2G2A
40threonine4410.9PIK3CA, CTNNB1, MSH6, BRAF, CCND1, MT-CYB
41arsenite44 2411.9PIK3CA, TP53, CCND1, CTNNB1
42arabinogalactan4410.9TLR2, TLR4
43indole-3-carbinol4410.9TP53, CCND1, CTNNB1
44sb-2167634410.9CCND1, CTNNB1
45fatty acid4410.8CTNNB1, MT-CO1, PLA2G2A, BRAF, TLR2
46alanine4410.8CTNNB1, TLR2, PLA2G2A, MT-CYB, TLR4, BRAF
47sulindac44 1111.8CCND1, TP53, CTNNB1
48depsipeptide4410.7CCND1, BRAF, TP53
49tacrolimus44 50 1112.6TLR2, CCND1, PIK3CA, TLR4
50superoxide44 2411.5PLA2G2A, MT-CYB, TLR4, TLR2, PIK3CA

GO Terms for genes affiliated with Colorectal Cancer

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Cellular components related to Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:03230010.6PMS2, MLH3

Biological processes related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of inflammatory responseGO:05072911.0TLR2, TLR4, PLA2G2A
2mismatch repairGO:00629811.0MSH6, PMS2, MLH3
3reciprocal meiotic recombinationGO:00713111.0MSH6, PMS2, MLH3
4cellular response to lipoteichoic acidGO:07122310.9TLR2, TLR4
5somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, PMS2
6positive regulation of macrophage cytokine productionGO:06090710.9TLR2, TLR4
7negative regulation of interleukin-17 productionGO:03270010.9TLR4, TLR2
8positive regulation of ERK1 and ERK2 cascadeGO:07037410.9BRAF, DCC, TLR4
9positive regulation of tumor necrosis factor biosynthetic processGO:04253510.9TLR2, TLR4
10mitotic G1 DNA damage checkpointGO:03157110.9TP53, CCND1
11positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.9TLR2, TLR4
12I-kappaB phosphorylationGO:00725210.9TLR2, TLR4
13somatic hypermutation of immunoglobulin genesGO:01644610.8PMS2, MSH6
14determination of adult lifespanGO:00834010.8TP53, MSH6
15positive regulation of chemokine productionGO:03272210.8TLR4, TLR2
16positive regulation of interleukin-10 productionGO:03273310.7TLR4, TLR2
17negative regulation of osteoclast differentiationGO:04567110.7TLR4, CTNNB1
18positive regulation of NF-kappaB import into nucleusGO:04234610.7TLR2, TLR4
19response to X-rayGO:01016510.6TP53, CCND1
20positive regulation of interferon-beta productionGO:03272810.6TLR4, TLR2
21positive regulation of interleukin-8 productionGO:03275710.5TLR4, TLR2
22ATP catabolic processGO:00620010.3MLH3, PMS2, MSH6

Molecular functions related to Colorectal Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0TLR4, TLR2, MLH3, PIK3CA, PMS2, TP53
2ATP bindingGO:00552410.8MSH6, BRAF, TP53, PMS2, MLH3, PIK3CA
3lipopolysaccharide receptor activityGO:00187510.8TLR4, TLR2
4chromatin bindingGO:00368210.8MLH3, TP53, MSH6, CTNNB1
5MutSalpha complex bindingGO:03240710.7PMS2, MLH3
6mismatched DNA bindingGO:03098310.7MSH6, MLH3
7transmembrane signaling receptor activityGO:00488810.7DCC, TLR4, TLR2
8ATPase activityGO:01688710.3MLH3, PMS2, MSH6

Products for genes affiliated with Colorectal Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Colorectal Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet