Colorectal Cancer malady

MedlinePlus: Cancer of the colon or rectum is also called colorectal cancer. in the united states, it is the fourth most common cancer in men and women. caught early, it is often curable. it is more common in people over 50, and the risk increases with age. you are also more likely to get it if you have polyps - growths inside the colon and rectum that may become cancerous a diet that is high in fat a family history or personal history of colorectal cancer ulcerative colitis or crohn's disease symptoms can include blood in the stool, narrower stools, a change in bowel habits and general stomach discomfort. however, you may not have symptoms at first, so screening is important. everyone who is 50 or older should be screened for colorectal cancer. colonoscopy is one method that your doctor can use to screen for colorectal cancer. treatments for colorectal cancer include surgery, chemotherapy, radiation or a combination. nih: national cancer institute²³

MalaCards: Colorectal Cancer, also known as carcinoma of the large intestine, is related to carcinoma and prostatitis. An important gene associated with Colorectal Cancer is DCC (deleted in colorectal carcinoma), and among its related pathways are Antioxidant Action of Vitamin-C and GSK3 Signaling. The compounds vegf and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia: Colorectal cancer, commonly known as colon cancer or bowel cancer, is a cancer from uncontrolled cell...⁴⁴ more...

OMIM: 114500

colorectal cancer 7 44 17 8 33 32 23 carcinoma of the large intestine 43

Disease types for colorectal cancer family:

colorectal cancer 3	colorectal cancer 4
colorectal cancer 10	colorectal cancer 11
colorectal cancer 2	colorectal cancer 5
colorectal cancer 6	colorectal cancer 7
colorectal cancer 8	colorectal cancer 9
colorectal cancer 1

Diseases related to colorectal cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 830)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	363.5	ZNF146, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
2	prostatitis	290.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
3	adenocarcinoma	269.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, KLF10
4	leukemia	265.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	pancreatitis	263.6	ZNF146, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
6	gastric cancer	237.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRRC3B
7	neuronitis	235.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
8	hepatocellular carcinoma	234.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
9	colon cancer	231.5	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, LRP6
10	melanoma	222.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
11	esophagitis	211.3	PIK3CB, PIK3CA, PIK3CG, PIN1, KLF4, KLF5
12	thyroiditis	203.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRPAP1
13	adenoma	183.0	PIK3CA, KLF4, NCAM1, PDCD4, RECK, REG1A
14	hypoxia	173.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP5
15	sarcoma	162.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
16	neuroblastoma	159.3	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
17	colon carcinoma	152.9	ZNF146, PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG
18	astrocytoma	122.3	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
19	cervicitis	121.8	PIK3CA, PIK3CG, PIN1, LRIG1, KL, RFC1
20	endometrial cancer	121.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
21	ischemia	118.7	PIK3CA, PIK3CG, COG2, KLF4, NCAM1, RETN
22	breast carcinoma	116.6	PIK3CA, PIK3R1, PIK3CG, LRPAP1, RECK, CNR2
23	obesity	116.5	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP5, COG2
24	peritonitis	109.9	LRPAP1, COG2, REG1A, REG4, RELB, RET
25	endometrial carcinoma	107.7	PIK3CB, PIK3CA, PIK3CG, LRPAP1, KLF9, CNR2
26	esophageal cancer	106.5	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
27	lupus erythematosus	106.4	PIK3CD, PIK3CG, COG2, PDCD1LG2, RECK, RETN
28	retinoblastoma	105.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6
29	polyposis	103.8	PIK3CG, PIN1, KLF4, KLF6, REEP5, RET
30	arthritis	102.9	PIK3CD, PIK3CG, PIN1, LRP5, KL, KLF5
31	pneumonia	102.7	COG2, KL, SELE, SETD2, SERPINA1, SERPINE1
32	gonococcal synovitis	102.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, NCAM1
33	cholangiocarcinoma	101.4	PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
34	anemia	101.2	NCAM1, SGOL1, KIT, KITLG, VWF, PCNA
35	ovarian carcinoma	97.2	PIK3CA, PIK3CG, PDCD4, RECK, KIT, PCNA
36	lung carcinoma	96.2	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
37	rheumatoid arthritis	95.8	PIK3CD, PIK3CG, PIN1, LRP5, KL, KLF5
38	fibrosis	95.0	PIK3CA, PIK3CG, PIN1, KL, KLF6, RECK
39	myeloid leukemia	95.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40	crohn's disease	92.9	KLF4, REG3A, REG4, RETN, CNR1, SFRP2
41	colon adenocarcinoma	91.3	KLF4, REG4, WARS, BUB1B, VIP, BSG
42	cervical cancer	91.2	PIK3CA, PIK3CG, PIN1, LRIG1, RFC1, SFN
43	oral cancer	91.2	RECK, SFN, SFRP1, SFRP2, SFRP4, PCNA
44	renal cell carcinoma	90.3	PIK3CA, RET, KIT, SFRP1, PCNA, SELP
45	alzheimer's disease	89.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
46	cholesterol	89.1	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
47	myeloma	88.3	PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP5, LRP6
48	insulin resistance	87.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, COG2
49	hepatitis b	84.5	PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6, NCK1
50	atherosclerosis	83.9	PIK3CG, LRP5, LRP6, LRPAP1, COG2, KL

Clinical features from OMIM: 114500

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to colorectal cancer:

²²

MGI Mouse Phenotypes related to colorectal cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	131.7	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
2	cellular phenotype	MP:0005384	122.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
3	immune system phenotype	MP:0005387	81.0	PIK3CD, PIK3R5, LRP5, KL, KLF5, PDCD4
4	nervous system phenotype	MP:0003631	77.5	LRIG1, LRP5, LRP6, LRPAP1, LRRC3B, KL
5	tumorigenesis	MP:0002006	70.1	PIK3CB, PIK3CA, PIK3R2, PIK3R1, LRIG1, KLF10
6	hematopoietic system phenotype	MP:0005397	65.9	KLF6, PDCD1LG2, KIT, VSIG4, SFN, SFRP1
7	embryogenesis phenotype	MP:0005380	56.4	PIK3CB, PIK3CA, LRP5, LRP6, KLF5, KLF6
8	muscle phenotype	MP:0005369	56.0	PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL, KLF5
9	vision/eye phenotype	MP:0005391	55.7	PIK3CA, PIN1, LRP5, LRP6, NCAM1, KIT
10	skeleton phenotype	MP:0005390	51.9	PIK3CD, PIK3CG, LRP6, KLF10, RECK, CNR1
11	renal/urinary system phenotype	MP:0005367	45.0	LRP6, LRPAP1, KL, NCK1, PDCD4, RET
12	no phenotypic analysis	MP:0003012	39.0	PIK3CD, PIK3R1, LRP6, PDCD1LG2, RET, CNR1
13	limbs/digits/tail phenotype	MP:0005371	38.1	LRIG1, LRP5, LRP6, KL, KLF10, RECK
14	liver/biliary system phenotype	MP:0005370	34.6	LRP5, LRP6, KLF6, RECK, RELB, RETN
15	adipose tissue phenotype	MP:0005375	34.4	PIK3CA, PIK3R1, LRP6, KL, RETN, SGMS1
16	endocrine/exocrine gland phenotype	MP:0005379	34.3	LRIG1, LRP5, LRPAP1, KL, KLF4, KLF5
17	craniofacial phenotype	MP:0005382	33.4	LRIG1, LRP5, LRP6, KLF4, KIT, KITLG
18	hearing/vestibular/ear phenotype	MP:0005377	30.1	LRP6, KIT, KITLG, SFN, RB1, RBP1
19	respiratory system phenotype	MP:0005388	26.1	LRP6, KL, KLF5, RELB, RET, SFRP4
20	pigmentation phenotype	MP:0001186	23.8	LRP5, KIT, KITLG, PCBD1, RB1, RBP1
21	other phenotype	MP:0005395	21.6	LRPAP1, KL, RECK, RELB, CNR1, VPS35
22	mortality/aging	MP:0010768	INF	PIK3CB, PIK3CA, LRP5, LRP6, LRPAP1, KL
23	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, LRIG1, LRP6, KL, KLF10
24	normal phenotype	MP:0002873	INF	PIK3R1, LRIG1, LRP5, LRP6, LRPAP1, KLF4
25	reproductive system phenotype	MP:0005389	INF	PIK3CA, LRP6, LRPAP1, KLF4, KLF6, PDCD4
26	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRP5, LRP6, KL, KLF4, KLF9
27	cardiovascular system phenotype	MP:0005385	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
28	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRP6
29	digestive/alimentary phenotype	MP:0005381	INF	LRIG1, LRP6, KL, KLF4, KLF5, RELB

Articles related to colorectal cancer:

(show top 50)    (show all 5319)

id	Title	Authors	Year	Affiliating Genes
1	Immunohistochemistry as first-line screening for dete cting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel . (19701074)	Shia J.... Klimstra D.S.	2009	MSH6, PMS2
2	Penetrance of colorectal cancer among MLH1/MSH2 carri ers participating in the colorectal cancer familial registry in Ontario. (19698169)	Choi Y.H.... Briollais L.	2009	MSH2, MLH1
3	SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. (19108950)	Zhang Y.... Lu J.	2009	SOX7
4	Expression of gamma-synuclein in colorectal cancer ti ssues and its role on colorectal cancer cell line HCT116. (19859996)	Ye Q.... Zheng M.H.	2009	SNCG
5	Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. (19124503)	Morita M.... Imaizumi N.	2009	CYP2E1
6	Previstage GCC Colorectal Cancer Staging Test: A New Molecular Test to Identify Lymph Node Metastases and Provide More Accurate Information about the Stage of Patients with Colorectal Cancer. (19351210)	Carlson M.R.	2009	GUCY2C
7	MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. (19156174)	Reeves S.G.... Scott R.J.	2009	MTHFR
8	The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. (19144677)	Hurwitz H.I.... Rosen O.	2009	KRAS
9	Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. (19016757)	Koga Y.... Matsumura Y.	2008	TP53, MMP7, PTGS2
10	Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer. (18425389)	Oshima T.... Imada T.	2008	MMP2, MMP9, MMP14
11	Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part II. The utility of microsatellite instability testing. (18556776)	Zhang L.	2008	BRAF, MLH1, MSH6
12	UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study. (18594531)	Kweekel D.M.... Guchelaar H.J.	2008	UGT1A1
13	Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): a novel biological marker in the detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy study group on colorectal cancer detection. (18224568)	Nielsen H.J.... .	2008	TIMP1
14	Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. (18027856)	Talseth B.A.... Scott R.J.	2008	CCND1, AURKA
15	Microsatellite analysis and hMLH1/hMSH2 expression d etection in young patients with colorectal cancer: value in screening hereditar y nonpolyposis colorectal cancer (17584637)	Yang L.... Zhang J.H.	2007	MLH1
16	Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients. (17406361)	Haug U.... Brenner H.	2007	PKM
17	Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. (17908962)	SA!nchez-de-Abajo A.... Caldes T.	2007	HRAS, BRAF, APC
18	Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. (17517051)	Yin G.... Imaizumi N.	2007	ALDH2, AKR1A1, ALDH9A1
19	Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability. (17117178)	Kets C.M.... Hoogerbrugge N.	2006	MSH2, MSH6, PMS2
20	Identification of mismatch repair gene mutations in y oung patients with colorectal cancer and in patients with multiple tumours asso ciated with hereditary non-polyposis colorectal cancer. (16636019)	Niessen R.C.... Kleibeuker J.H.	2006	MSH2, MLH1, MSH6
21	Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany. (17095871)	Lamberti C.... Mathiak M.	2006	MSH2, MLH1, MSH6
22	A new quantitative DNA-methylation analysis of MSI colorectal cancers helps to separate sporadic colorectal cancers from HNPCC-candidates (17867602)	Bettstetter M.... Dietmaier W.	2006	BRAF
23	Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer, liver metastasis of colorectal cancer and hepatocellular carcinoma. (16773701)	Mathonnet M.... Denizot Y.	2006	FGF2
24	Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. (16421660)	Yamaguchi T.... Miyaki M.	2006	TGFBR2, PTEN, BAX
25	Frequency of hereditary non-polyposis colorectal cancer among Uruguayan patients with colorectal cancer. (15952990)	Sarroca C.... Lynch H.	2005	MSH2, MLH1, MSH6
26	Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. (15805302)	Hagiwara T.... Imaizumi N.	2005	CYP7A1
27	Antioxidant status of patients with primary colorectal cancer and liver metastases of colorectal cancer (15859549)	Czeczot H.... Porembska Z.	2005	CAT
28	Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe) (15138699)	RA1schoff J.... BA1ttner R.	2004	MSH2, MSH6, PMS2
29	Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. (15449173)	Kim I.J.... Park J.G.	2004	BRAF, APC, CTNNB1
30	Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German hereditary nonpolyposis colorectal cancer consortium. (15483016)	Plaschke J.... Schackert H.K.	2004	MSH2, MLH1, MSH6
31	What is the best way to assess microsatellite instabi lity status in colorectal cancer? Study on a population base of 462 colorectal cancers. (15577673)	Chapusot C.... Piard F.	2004	MLH1
32	Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). (15596632)	Watson P.... Roy H.K.	2004	MSH2, MLH1
33	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. (15546509)	Yin G.... Imaizumi N.	2004	MTHFR
34	Allelic imbalance in colorectal cancer at the CRAC1 locus in early-onset colorectal cancer. (12885466)	Popat S.... Houlston R.S.	2003	CRAC1
35	Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry. (11910346)	Terdiman J.P.... Kim Y.S.	2002	MSH2, MLH1
36	Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene. (11782355)	Shin K.H.... Park J.G.	2002	MSH2, MLH1
37	Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer. (11819827)	Li X.G.... Wang Y.Q.	2001	WSB2
38	Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions (11707995)	Ishida H.... Miura T.	2001	DPYD, TYMP
39	Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. (11571580)	Sasaki Y.... Tokino T.	2001	TP53, TP73
40	Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer. The RANX05 Colorectal Cancer Study Group. (11005561)	Nielsen H.J.... Brunner N.	2000	SERPINE1, CRP
41	Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients. (10690536)	Shin K.H.... Park J.G.	2000	TGFBR2
42	Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population. (10378595)	Shashidharan M.... Lynch H.T.	1999	MSH2, MLH1
43	Germline mutation analysis in hMLH 1 and hMSH 2 genes in hereditary nonpolyposis colorectal cancer and colorectal cancer patients with familial history (9845760)	Wang Y.... Propping P.	1998	MLH1
44	Correlations between cell proliferating activity and apoptosis in the colorectal cancer and apoptosis in the mucosa adjacent to colorectal cancer (9263520)	Watanabe I.... Tanigawa N.	1997	PCNA
45	Interleukin-7 (IL-7) in colorectal cancer: IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes. (9042431)	Maeurer M.J.... Lotze M.T.	1997	IL7
46	Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer. (8985467)	Satoh Y.... Tsuji T.	1996	CTSB
47	Randomized trial assessing the addition of interferon alpha-2a to fluorouracil and leucovorin in advanced colorectal cancer. Colorectal Cancer Working Party of the United Kingdom Medical Research Council. (8708718)	Seymour M.T.... Taylor I.	1996	IFNA2, IFNA1
48	Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells. (8687156)	Partanen S.	1996	ACP1, PTS, PTPRU
49	Colorectal cancer: future population screening for early colorectal cancer. (7577053)	Blum H.E.	1995	RAN
50	'Tomudex' (ZD1694): results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leuco penia. The 'Tomudex' Colorectal Cancer Study Group. (8562146)	Cunningham D.... Perez-Manga G.	1995	TYMS

Genes related to colorectal cancer according to GeneCards:

(show top 50)    (show all 1852)

id	Symbol	Description	Score	GeneCards Section Context
1	DCC	deleted in colorectal carcinoma	11.1	Databases, Publications, Aliases & Descriptions, Pathways & Interactions (show all 5 sections) Summaries
2	GALNT12	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	11.1	Publications, Aliases & Descriptions, Summaries
3	MLH3	mutL homolog 3 (E. coli)	11.1	Publications, Summaries
4	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	11.1	Publications, Summaries
5	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.1	Publications, Summaries
6	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.1	Publications, Pathways & Interactions, Summaries
7	SMAD7	SMAD family member 7	11.1	Publications, Summaries
8	CRCS10	Colorectal cancer, susceptibility to, 10	11.0	Aliases & Descriptions
9	CRCS7	colorectal cancer, susceptibility to, 7	11.0	Aliases & Descriptions
10	CRCS8	Colorectal cancer, susceptibility to, 8	11.0	Aliases & Descriptions
11	CRCS11	Colorectal cancer, susceptibility to, 11	11.0	Aliases & Descriptions, Publications
12	CRCS5	Colorectal cancer, susceptibility to, 5	11.0	Publications, Aliases & Descriptions
13	CRCS6	colorectal cancer, susceptibility to, 6	11.0	Publications, Aliases & Descriptions
14	CRCS9	colorectal cancer, susceptibility to, 9	11.0	Publications, Aliases & Descriptions
15	AXIN2	axin 2	11.0	Publications, Pathways & Interactions, Summaries
16	CRCS2	Colorectal cancer, susceptibility to, 2	11.0	Publications, Aliases & Descriptions
17	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications, Pathways & Interactions, Summaries
18	SFRP2	secreted frizzled-related protein 2	11.0	Publications, Summaries
19	LGALS4	lectin, galactoside-binding, soluble, 4	11.0	Publications, Summaries
20	MAPRE1	microtubule-associated protein, RP/EB family, member 1	11.0	Publications, Summaries
21	PPARD	peroxisome proliferator-activated receptor delta	11.0	Publications, Summaries
22	MAPRE2	microtubule-associated protein, RP/EB family, member 2	11.0	Publications, Functions, Summaries
23	MCC	mutated in colorectal cancers	11.0	Publications, Transcripts, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
24	HOXB8	homeobox B8	11.0	Summaries
25	HOXB6	homeobox B6	11.0	Summaries
26	RPS12	ribosomal protein S12	11.0	Publications, Summaries
27	CHSY1	chondroitin sulfate synthase 1	11.0	Publications, Summaries
28	PDGFRL	platelet-derived growth factor receptor-like	11.0	Publications, Summaries
29	RPL5	ribosomal protein L5	11.0	Publications, Summaries
30	RPS9	ribosomal protein S9	11.0	Summaries
31	ANTXR1	anthrax toxin receptor 1	11.0	Publications, Summaries
32	CABLES1	Cdk5 and Abl enzyme substrate 1	11.0	Publications, Summaries
33	EPDR1	ependymin related protein 1 (zebrafish)	11.0	Aliases & Descriptions
34	TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	11.0	Aliases & Descriptions
35	CBLN4	cerebellin 4 precursor	11.0	Summaries
36	HOTAIR	HOX transcript antisense RNA	11.0	Summaries
37	WNT10A	wingless-type MMTV integration site family, member 10A	11.0	Pathways & Interactions, Summaries
38	WNT6	wingless-type MMTV integration site family, member 6	11.0	Pathways & Interactions, Summaries
39	RPL28	ribosomal protein L28	11.0	Summaries
40	RPS10	ribosomal protein S10	11.0	Summaries
41	RPS29	ribosomal protein S29	11.0	Summaries
42	RPL27A	ribosomal protein L27a	11.0	Summaries
43	RPS5	ribosomal protein S5	11.0	Summaries
44	SLC16A7	solute carrier family 16, member 7 (monocarboxylic acid transporter 2)	11.0	Summaries
45	DOCK4	dedicator of cytokinesis 4	11.0	Summaries
46	PTPRR	protein tyrosine phosphatase, receptor type, R	11.0	Summaries
47	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
48	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
49	MSH6	mutS homolog 6 (E. coli)	11.0	Publications, Functions, Pathways & Interactions
50	APC	adenomatous polyposis coli	11.0	Publications, Pathways & Interactions

Pathways related to colorectal cancer according to GeneDecks:

(show top 50)    (show all 428)

id	Pathway	Score	Top Affiliating Genes
1	Antioxidant Action of Vitamin-C36	31.9	KIT, KITLG, VEGFB, VEGFC, MYH1, MYO18B
2	GSK3 Signaling36	30.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
3	MAPK Signaling36	28.4	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
4	Endothelin-1 Signaling Pathway36	24.4	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, BRAF
5	Activation of PKA through GPCR36	22.7	KIT, KITLG, BRAF, VEGFB, VEGFC, BMP1
6	NF-KappaB Family Pathway36	22.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RELB, KITLG
7	JNK Pathway36	21.3	PIK3R4, PIK3R1, KIT, KITLG, VEGFB, BMP1
8	Activation of cAMP-Dependent PKA36	20.9	KITLG, VEGFB, VEGFC, BMP1, BMP2, BMP3
9	Activation of PKC through GPCR36	20.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
10	UPA-UPAR Pathway36	19.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, SERPINE1, LAMA1
11	Rap1 Pathway36	18.8	KITLG, BRAF, VEGFB, VEGFC, BMP1, BMP2
12	Development_IGF-1 receptor signaling41	17.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
13	Regulation of eIF4 and p70S6K36	16.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, VEGFC, BMP1
14	Endometrial cancer20	16.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
15	Development_Prolactin receptor signaling41	16.4	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VAV1
16	Development_EGFR signaling pathway41	16.4	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, NCK1
17	HGF Pathway36	15.9	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RB1, RAF1
18	Development TGF-beta receptor signaling10	15.8	KLF10, RELB, SERPINE1, RAF1, ZFYVE9, CHUK
19	Pertussis20	15.1	CFL1, JUN, CD14, ITGA5, ITGB1, ITGB2
20	Selected targets of GCR-alpha10	14.7	KITLG, LEP, CGA, CFL1, CDKN1A, INS
21	B cell receptor signaling pathway20	14.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
22	Immune response IL-10 signaling pathway10	14.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
23	VEGF Family Ligands and Receptor Interactions36	14.4	PIK3R3, PIK3R2, PIK3R4, PIK3R1, VEGFB, VEGFC
24	Development Angiopoietin - Tie2 signaling10	14.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
25	Apoptosis and survival Caspase cascade10	13.8	LMNA, BID, PARP1, BAX, XIAP, IRS1
26	Immune response_Oncostatin M signaling via MAPK in human cells41	13.6	RAF1, RAC1, LDLR, CEBPB, JUN, JAK1
27	Apoptosis and survival_Caspase cascade41	13.6	LMNA, BID, PARP1, BAX, XIAP, IRS1
28	Fc epsilon RI signaling pathway20	13.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
29	Transcription Receptor-mediated HIF regulation10	13.0	PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1, IRS1
30	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	13.0	PIK3CB, PIK3CD, PIK3R2, PIK3R1, BAD, MAP2K2
31	Development_FGFR signaling pathway41	12.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
32	Actin-Based Motility by Rho Family GTPases36	12.7	BMP1, BMP3, BMP4, BMP7, RAC3, RAC2
33	Pancreatic cancer20	12.5	PIK3R3, PIK3R2, PIK3R5, BRCA2, RALGDS, RAC3
34	Inflammasome Activation Pathways37	12.4	RELB, CHUK, JUN, FOS, IL18, IL1B
35	Signal transduction_PTEN pathway41	12.4	PCNA, ITGA5, ITGB1, IRS1, GSK3B, IGF1R
36	ErbB2-ErbB3 Heterodimers36	12.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RAF1, BAD
37	ErbB4 Pathway36	12.2	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, RAF1
38	NFAT and Cardiac Hypertrophy36	12.1	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RAF1, GSK3B
39	Development_Dopamine D2 receptor transactivation of EGFR41	11.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40	AMPK Enzyme Complex Pathway36	10.7	PIK3R3, PIK3R2, PIK3R4, PIK3R1, LEP, IRS1
41	Development_EPO-induced MAPK pathway41	10.4	PIK3CG, KIT, KITLG, VAV1, RAF1, RAC1
42	Development_ACM2 and ACM4 activation of ERK41	9.9	PIK3CG, RAF1, FOS, GRB2, MAP2K2, MAPK3
43	Development A3 receptor signaling10	9.8	PIK3R5, PIK3CG, RELB, MYC, RAF1, CHUK
44	Apoptosis and survival_BAD phosphorylation41	9.5	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1
45	Development A1 receptor signaling10	9.4	PIK3R5, PIK3CG, RELB, RAF1, RAC1, CHUK
46	G-protein signaling G-Protein alpha-q signaling cascades10	9.3	GNB1, GNB4, GNB5, GNG10, GNG11, GNG12
47	Alpha-Adrenergic Signaling36	9.3	BRAF, RAF1, MAP2K6, MAP2K2, MAP2K3, MAP2K4
48	Relaxin Pathway36	8.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, JUN
49	Beta-Adrenergic Signaling36	7.4	BRAF, RAF1, ATP2A2, MAP2K6, MAP2K2, MAP2K3
50	Lymphocyte Signaling3	INF	NCAM1, NCK1, KIT, KITLG, BMI1, BCL10

Compounds related to colorectal cancer according to GeneDecks:

(show top 50)    (show all 432)

id	Compound	Score	Top Affiliating Genes
1	vegf32	73.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KL, NCAM1
2	estrogen32	69.2	PIK3CB, PIK3R1, LRP5, COG2, KLF10, KLF5
3	doxorubicin32 34 9 9	47.6	PIK3CA, PIK3CG, NCAM1, RECK, KIT, KITLG
4	adenylate32	41.0	PIK3CA, PIK3CG, KLF6, CNR1, CNR2, KITLG
5	h2o232	37.6	PIK3CB, PIK3R1, PIK3CG, KITLG, VWF, RCAN1
6	histamine32 18	31.4	PIK3CA, NCAM1, CNR1, KIT, KITLG, VWF
7	folate32	29.9	RECK, VWF, SELE, VIM, NAT1, NAT2
8	glyceraldehyde 3-phosphate32	29.1	SETD2, VEGFC, MYCN, RARS, BLZF1, BIRC5
9	ethanol32 34 9 18 9	32.7	KL, NCAM1, KITLG, RBP1, SERPINA1, BMP7
10	polysaccharide32	27.9	NCAM1, RECK, KITLG, GCNT1, SELE, SELP
11	chloramphenicol32 9 9	29.8	KLF9, GC, SELE, SETD2, SERPINE1, VIM
12	camptothecin32 42 9 9	29.5	PIK3CG, PCNA, RB1, NBN, SETD2, BRCA1
13	acetylcholine32 9 18 9	29.1	NCAM1, CNR1, VWF, VIM, VIP, LPL
14	phospholipid32	25.6	PIK3CB, PIK3R1, COG2, VWF, RBP1, RBP2
15	tacrolimus32 34 9 9	27.0	PIK3CA, PIN1, RCAN1, PCNA, SERPINE1, VDR
16	prostaglandin32	23.7	KITLG, VIM, VIP, VEGFC, MYOD1, MUC5AC
17	carbon32	23.2	CNOT7, CNR1, CNR2, VWF, PCNA, LPL
18	cytochalasin d32 42	23.9	PIK3CG, KITLG, VWF, SELE, VIM, LPL
19	ag 147832	21.3	PIK3CA, PIK3CG, SERPINE1, RAF1, MUC5AC, BAK1
20	gefitinib32 34 9 9	24.3	PIK3CA, PIK3CG, KIT, SELP, VIM, VEGFA
21	magnesium32 9 18 9	24.0	GC, BMPR1A, BMPR2, RAD51, RAN, RAC1
22	hydrocortisone32 9 9	22.3	KITLG, VIM, BMP6, KDR, MUC1, LCT
23	oxaliplatin32 34 9 9	22.9	BRCA1, VEGFA, BIRC5, BCL2L1, UGT1A1, MTHFR
24	homocysteine32 18	20.8	COG2, RETN, VWF, SELE, SELP, SERPINE1
25	mifepristone32 42 9 9	22.6	BIRC5, ZFP36, BCL2L1, LGALS4, MUC1, LCK
26	sodium dodecylsulfate32	18.5	VWF, SERPINB6, SERPINE1, LPL, MYC, BMP6
27	estrone32 9 18 9	21.5	LPL, LEP, UGT1A, UGT1A1, UGT1A6, UGT1A7
28	benzo(a)pyrene32	18.4	RB1, NAT2, BRCA1, RARB, UGT1A, UGT1A1
29	epoxide32	18.0	GC, NAT1, NAT2, UGT1A, UGT1A1, UGT1A7
30	topotecan32 9 9	19.4	SETD2, BRCA1, RAN, BIRC5, PARP1, BCL2
31	sialic acid32	17.4	NCAM1, RECK, GCNT1, CLU, BCR, LGALS1
32	choline32 9 18 9	20.2	RET, VIM, VIP, MYB, RAF1, BLVRB
33	phenylalanine32	17.1	PIK3R1, NCK1, PCBD1, VAV1, BLZF1, BDNF
34	rottlerin32 42	17.9	PIK3R1, PIK3CG, VCAM1, RAC1, PARP1, XIAP
35	melphalan32 9 9	18.3	RAD51, BIRC5, BCL2L1, BCL2L11, MUC16, XRCC3
36	noxa32	16.1	BID, BIRC5, BCL2, BCL2L1, BCL2L11, BBC3
37	inositol32	16.0	PIK3CB, PIK3CD, LPL, BDNF, BCR, CHGA
38	androstane32	15.4	VDR, UGT1A, UGT1A1, GSTA1, HNF1A, HNF4A
39	allergens32	15.4	BLZF1, LGALS3, CIITA, S100A8, CETP, CD209
40	phenytoin32 34 9 9	18.3	CNR1, BMP6, KCNH2, UGT1A, UGT1A1, MTHFR
41	methylcellulose32	15.1	KIT, KITLG, VAV1, MYB, BMP2, CD14
42	propranolol32 34 9 18 9	18.9	VIP, KCNH2, CHGA, UGT1A9, LDLR, BAD
43	rotenone32	14.9	PIK3CG, PARP1, PARK2, BCL2, BCL2L1, BAD
44	sulindac sulfide32	14.7	PCNA, BMP6, BCL2, BCL2L1, BAX, ATF3
45	kininogen32	14.6	VWF, SELP, SERPINE1, CLU, CLEC3B, MPO
46	dextran sulfate32	14.6	SELE, SELP, LPL, CIITA, LDLR, CFP
47	taxane32	14.2	VEGFA, BIRC5, KDR, BCL2, MTOR, MTHFR
48	tpck32	13.7	PIK3CG, PARP1, BCL2L1, BAK1, JUN, IL1B
49	gm-csf32	13.7	KITLG, VEGFA, BMP6, BCL2L1, CD14, IL10
50	serine32	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1

Cellular components related to colorectal cancer according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	99.7	ZNF146, ZNF346, PIK3CB, PIK3R5, PIN1, KLF10
2	cytoplasm	GO:005737	96.3	ZNF146, ZNF346, PIK3R5, PIK3CG, PIN1, KLF6
3	cytosol	GO:005829	76.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R4
4	plasma membrane	GO:005886	72.5	PIK3CD, PIK3R1, PIK3CG, LRP5, LRP6, LRPAP1
5	extracellular region	GO:005576	53.0	LRPAP1, KL, NCAM1, PDCD1LG2, REG1A, REG4
6	extracellular space	GO:005615	46.8	KL, REG3A, KIT, KITLG, SFN, SFRP1
7	nucleoplasm	GO:005654	41.5	PIN1, RFC1, RFC3, PCNA, RB1, NBN
8	integral to plasma membrane	GO:005887	39.5	KL, RET, SGCE, CNR1, CNR2, SELP
9	cell surface	GO:009986	25.9	LRP6, LRPAP1, NCAM1, SFRP1, SFRP4, VEGFA
10	membrane	GO:016020	25.2	PIK3R5, PIK3CG, RECK, VPS35, GCNT3, SELENBP1
11	perinuclear region of cytoplasm	GO:048471	23.3	BUB1B, GC, SELE, SEPT9, LMNA, RAD51
12	proteinaceous extracellular matrix	GO:005578	18.3	VWF, SFRP1, SERPINA1, VEGFA, BMP4, LGALS1
13	external side of plasma membrane	GO:009897	17.4	NCAM1, KIT, VWF, SELP, VCAM1, KDR
14	membrane raft	GO:045121	16.2	SELE, BSG, BCL10, LCK, FURIN, JAK2
15	platelet alpha granule lumen	GO:031093	14.8	VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, VEGFC

Biological processes related to colorectal cancer according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	45.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R4
2	signal transduction	GO:007165	37.1	PIK3CB, PIK3CD, RET, CNOT7, KIT, KITLG
3	apoptotic process	GO:006915	36.9	ZNF346, PDCD4, SGMS1, SFN, BUB1, BUB1B
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	34.6	LRP5, LRP6, KLF4, KLF6, NCK1, CNOT7
5	positive regulation of cell proliferation	GO:008284	31.9	LRP5, KLF5, REG1A, KIT, SFRP1, SFRP2
6	positive regulation of transcription, DNA-dependent	GO:045893	31.5	LRP5, LRP6, KLF4, KLF5, KLF6, RET
7	negative regulation of cell proliferation	GO:008285	31.0	KLF10, KLF4, WARS, SFN, SFRP1, SFRP2
8	blood coagulation	GO:007596	27.4	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
9	cell proliferation	GO:008283	25.8	KLF10, REG3A, KITLG, KIF2C, SFN, PCNA
10	negative regulation of transcription, DNA-dependent	GO:045892	25.4	KLF4, PDCD4, SFRP1, SFRP2, BTRC, RB1
11	virus-host interaction	GO:019048	23.9	PIK3R1, BUB1, BTRC, RB1, VIM, VCAM1
12	anti-apoptosis	GO:006916	23.5	PIK3CA, SERPINB2, VIMP, BRAF, VHL, VEGFB
13	DNA repair	GO:006281	23.0	RFC1, RFC3, PCNA, RBBP8, NBN, BRCA1
14	innate immune response	GO:045087	22.4	PIK3CD, PIK3R4, PIK3CG, PIN1, CLU, BCL10
15	cell-cell signaling	GO:007267	21.6	KLF10, SFRP2, BMP2, BMP3, S100A9, CGA
16	xenobiotic metabolic process	GO:006805	21.5	NAT1, NAT2, PAOX, UGT1A1, UGT1A6, UGT1A9
17	induction of apoptosis	GO:006917	21.4	KLF10, BOK, BNIP3, BNIP3L, BIK, BCL10
18	axon guidance	GO:007411	20.8	NCAM1, NCK1, SEMA6A, RAF1, RAC1, RAC2
19	platelet activation	GO:030168	20.1	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
20	positive regulation of cell migration	GO:030335	19.5	RET, VEGFA, BMP2, KDR, LEF1, LAMB1
21	protein phosphorylation	GO:006468	19.5	PIK3CD, PIK3R4, RET, BRAF, MYOD1, BMPR1A
22	response to organic cyclic compound	GO:014070	18.9	SFRP1, SELP, SERPINA1, BMP4, LEF1, UGT1A1
23	transforming growth factor beta receptor signaling pathway	GO:007179	18.5	KLF10, SERPINE1, MYC, BMPR1A, ZFYVE9, PARP1
24	response to lipopolysaccharide	GO:032496	18.4	CNR1, CNR2, SELE, SELP, SERPINA1, UGT1A1
25	cell surface receptor signaling pathway	GO:007166	18.0	SEMA6A, BSG, BRD8, BIRC2, BIRC3, LEPR
26	response to estradiol stimulus	GO:032355	17.8	SFRP4, GC, SERPINA1, BRCA2, VDR, BMP4
27	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	17.7	BOK, MYC, BCL2L11, BBC3, LCK, BAD
28	Wnt receptor signaling pathway	GO:016055	17.6	LRP5, LRP6, SFRP4, BTRC, BRD7, LEF1
29	cytokine-mediated signaling pathway	GO:019221	17.6	PIN1, KLF6, NCAM1, KIT, VCAM1, CIITA
30	positive regulation of protein phosphorylation	GO:001934	17.6	PIN1, VEGFA, BMP2, BMP4, MTOR, AXIN1
31	aging	GO:007568	16.9	KL, CNR1, VDR, VCAM1, BAK1, FURIN
32	heart development	GO:007507	16.9	PCNA, VCAM1, BMP2, RAF1, ATM, MRE11A
33	positive regulation of ERK1 and ERK2 cascade	GO:070374	16.8	BRAF, VEGFB, BMP2, BMP4, KDR, CD44
34	phosphatidylinositol-mediated signaling	GO:048015	16.7	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PCNA, BUB1B
35	protein autophosphorylation	GO:046777	16.5	KIT, MYO3A, PAK1, KDR, CHEK2, ZAP70
36	platelet degranulation	GO:002576	16.3	VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFB
37	positive regulation of angiogenesis	GO:045766	16.2	SFRP2, SERPINE1, VEGFA, KDR, CD34, MMP9
38	cellular response to hypoxia	GO:071456	16.1	SFRP1, VHL, VEGFA, LMNA, BNIP3, BMP7
39	response to ethanol	GO:045471	16.0	CNR1, BCL2, LCT, BAK1, S100A8, S100A9
40	positive regulation of endothelial cell proliferation	GO:001938	15.8	VEGFA, VEGFB, BMP2, BMP4, BMP6, BMPR2
41	peptidyl-tyrosine phosphorylation	GO:018108	15.8	KIT, KDR, ZAP70, JAK1, JAK2, FLT1
42	response to estrogen stimulus	GO:043627	15.8	RCAN1, SERPINE1, BRCA1, BCL2, LCT, CD24
43	nerve growth factor receptor signaling pathway	GO:048011	15.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, BRAF, VAV1
44	positive regulation of MAPK cascade	GO:043410	15.4	KIT, LPAR1, LPAR2, LPAR3, KDR, LEP
45	canonical Wnt receptor signaling pathway	GO:060070	15.1	LRP5, LRP6, SFRP1, MYC, BCL9, BCL9L
46	epidermal growth factor receptor signaling pathway	GO:007173	14.9	PIK3CA, PIK3R1, RAF1, CHUK, BAD, MTOR
47	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	14.5	KIT, SELP, KDR, JAK2, FLT1, FLT3
48	cellular response to mechanical stimulus	GO:071260	13.9	BNIP3, BCL10, CHEK1, BAD, BAK1, CD40
49	energy reserve metabolic process	GO:006112	8.9	KL, MYC, LEP, LEPR, INS, MC4R
50	cellular response to glucagon stimulus	GO:071377	6.2	ARG1, GNAS, GNB1, GNB2, GNB3, GNB4

Molecular functions related to colorectal cancer according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	41.3	PIK3CB, PIK3CD, PIK3CA, PIK3R4, PIK3CG, RFC1
2	protein heterodimerization activity	GO:046982	22.9	BRAF, VEGFA, VEGFB, BOK, BNIP3, BNIP3L
3	enzyme binding	GO:019899	22.4	VIMP, BRCA1, VHL, RAC1, BLZF1, BIRC5
4	transcription factor binding	GO:008134	21.9	RB1, NBN, BRD7, VHL, MYC, MYOD1
5	growth factor activity	GO:008083	20.2	REG1A, KITLG, VEGFA, VEGFB, VEGFC, BMP1
6	protein kinase binding	GO:019901	19.9	VIM, LLGL1, ZFP36, PAK1, PARK2, BCL10
7	receptor binding	GO:005102	19.9	LRP6, NCK1, SERPINE1, LPL, BMP2, BMP3
8	transcription regulatory region DNA binding	GO:044212	19.1	KLF4, BRCA1, BRD7, LEF1, CIITA, XRCC5
9	cytokine activity	GO:005125	18.0	KITLG, VEGFA, BMP1, BMP2, BMP3, BMP4
10	heparin binding	GO:008201	17.2	ZNF146, LRPAP1, SFRP1, SELP, VEGFA, VEGFB
11	beta-catenin binding	GO:008013	16.0	BTRC, BCL9, BCL9L, LEF1, AXIN1, AXIN2
12	ubiquitin protein ligase binding	GO:031625	15.8	RB1, BRCA1, MYOD1, RAD18, BLZF1, BID
13	signal transducer activity	GO:004871	15.2	KL, CNOT7, CLOCK, LGALS1, CHKA, S100A9
14	protein tyrosine kinase activity	GO:004713	15.0	RET, KIT, KDR, BCR, SCYL1, ZAP70
15	protein homodimerization activity	GO:042803	INF	LRP6, KIT, VWF, VEGFA, VEGFB, BNIP3
16	sequence-specific DNA binding transcription factor activity	GO:003700	INF	KLF10, KLF4, KLF5, KLF6, KLF9, RELB
17	identical protein binding	GO:042802	INF	SFRP1, PCBD1, PCNA, VIM, BNIP3, BNIP3L
18	protein binding	GO:005515	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R4, PIK3R1