MCID: CLR085
MIFTS: 46

Colorectal Cancer 1

Categories: Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 1

MalaCards integrated aliases for Colorectal Cancer 1:

Name: Colorectal Cancer 1 54 71 29
Susceptibility to Colorectal Cancer on Chromosome 9 71
Susceptibility to Colorectal Adenoma and Cancer 71
Colorectal Cancer, Susceptibility to, 1 13
Crcs1 71

Classifications:



External Ids:

OMIM 54 608812
MedGen 40 C1837315
MeSH 42 D015179

Summaries for Colorectal Cancer 1

UniProtKB/Swiss-Prot : 71 Colorectal cancer 1: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

MalaCards based summary : Colorectal Cancer 1, also known as susceptibility to colorectal cancer on chromosome 9, is related to colorectal cancer and colorectal cancer, hereditary nonpolyposis, type 1. An important gene associated with Colorectal Cancer 1 is GALNT12 (Polypeptide N-Acetylgalactosaminyltransferase 12), and among its related pathways/superpathways are Innate Immune System and Metabolism of proteins. The drugs Fluorouracil and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and lung.

Description from OMIM: 608812

Related Diseases for Colorectal Cancer 1

Diseases in the Colorectal Cancer family:

Colorectal Cancer 6 Colorectal Cancer 2
Colorectal Cancer 1 Colorectal Cancer 5
Colorectal Cancer 7 Colorectal Cancer 12
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11 Familial Colorectal Cancer
Hereditary Colorectal Cancer Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 colorectal cancer 27.5 GALNT12 MSH2 MUC1 MUC12 MUC2 MUC3A
2 colorectal cancer, hereditary nonpolyposis, type 1 11.5
3 thyroid gland disease 10.7 MSH2 MUC6
4 tuberculous salpingitis 10.7 MUC1 MUC5B
5 morbid obesity 10.7 MUC1 MUC6
6 bile duct mucoepidermoid carcinoma 10.7 MUC1 MUC5AC
7 stricture or kinking of ureter 10.7 MUC1 MUC2
8 bile duct clear cell adenocarcinoma 10.7 MUC2 MUC5AC
9 anemia of prematurity 10.7 MUC1 MUC2
10 ovarian mucinous adenocarcinoma 10.7 MUC1 MUC2
11 proliferative type fibrocystic change of breast 10.6 MUC1 MUC5AC
12 polysyndactyly with cardiac malformation 10.6 MUC2 MUC5AC
13 advanced sleep phase syndrome 10.6 MUC1 MUC2 MUC4
14 brain angioma 10.6 MUC2 MUC5AC
15 postinflammatory pulmonary fibrosis 10.6 MUC1 MUC5B
16 papilloma 10.6 MUC1 MUC4 MUC6
17 situs inversus 10.6 MUC1 MUC2 MUC6
18 urinary system disease 10.6 MUC1 MUC2 MUC6
19 pleomorphic rhabdomyosarcoma 10.6 MUC1 MUC5B
20 urethra adenocarcinoma 10.6 MUC1 MUC2 MUC4
21 tabes dorsalis 10.6 MUC1 MUC2 MUC6
22 spastic ataxia 3 10.6 MUC1 MUC6
23 migraine with aura 10.6 MUC1 MUC2 MUC6
24 optic papillitis 10.6 MSH2 MUC2 MUC6
25 klatskin's tumor 10.6 MUC1 MUC4
26 pancreatic signet ring cell adenocarcinoma 10.6 MUC1 MUC2 MUC6
27 liver disease 10.6 MUC1 MUC4 MUC5AC
28 choriocarcinoma 10.5 MUC1 MUC2 MUC6
29 fallopian tube leiomyosarcoma 10.5 MUC1 MUC2 MUC6
30 encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 10.5 MUC1 MUC2 MUC5AC
31 peritoneal serous adenocarcinoma 10.5 MUC1 MUC2 MUC5AC
32 thymus lymphoma 10.5 MUC1 MUC4 MUC5AC
33 intracranial sinus thrombosis 10.5 MUC2 MUC5AC MUC6
34 childhood ovarian endodermal sinus tumor 10.4 MUC2 MUC5AC MUC6
35 premature ovarian failure 12 10.4 MUC2 MUC5AC MUC5B
36 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.4 MUC2 MUC5AC MUC6
37 malignant biphasic mesothelioma 10.4 MUC1 MUC2 MUC4 MUC6
38 x-linked intellectual disability, van esch type 10.4 MUC16 MUC5AC
39 struma ovarii 10.4 MUC1 MUC2 MUC4 MUC6
40 prostate small cell carcinoma 10.4 MUC2 MUC5AC
41 trachea squamous cell carcinoma 10.4 MSH2 MUC1 MUC16
42 serous cystadenocarcinoma 10.4 MUC1 MUC16 MUC2
43 acinar cell cystadenocarcinoma 10.3 MUC1 MUC2 MUC5AC MUC5B
44 uterine corpus apoplectic leiomyoma 10.3 MUC1 MUC2 MUC5AC MUC5B
45 condrodisplasia punctata rizomélica 10.3 MUC1 MUC5AC
46 ectodermal dysplasia with natal teeth, turnpenny type 10.3 MUC1 MUC2 MUC4 MUC5AC
47 nominal aphasia 10.3 MUC1 MUC2 MUC4 MUC5AC
48 vocal cord scarring 10.3 MSH2 MUC12 MUC2
49 idiopathic central precocious puberty 10.3 MUC2 MUC3A MUC4 MUC5AC
50 testicular trophoblastic tumor 10.3 MUC1 MUC2 MUC5AC MUC6

Graphical network of the top 20 diseases related to Colorectal Cancer 1:



Diseases related to Colorectal Cancer 1

Symptoms & Phenotypes for Colorectal Cancer 1

Clinical features from OMIM:

608812

Drugs & Therapeutics for Colorectal Cancer 1

Drugs for Colorectal Cancer 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 635)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
2
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
4
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
5
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
6
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
7
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
8
Tegafur Approved Phase 4,Phase 3,Phase 1,Phase 2 17902-23-7 5386
9
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 137-58-6 3676
10
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
11
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
12
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
13
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
14
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
15
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
16
Ethiodized oil Approved Phase 4,Phase 2 8008-53-5
17
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
18
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
19
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
21
Menadione Approved, Nutraceutical Phase 4,Phase 2,Phase 1 58-27-5 4055
22
Phytonadione Approved, Nutraceutical Phase 4,Phase 2,Phase 1 84-80-0 4812 5284607
23 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
24
Iodine Investigational Phase 4,Phase 1 7553-56-2 807
25
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1 7689-03-4
26 Antidotes Phase 4,Phase 3,Phase 2,Phase 1
27 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
28 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
29 cadexomer iodine Phase 4,Phase 1
30 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 triamcinolone acetonide Phase 4,Phase 2
36 Triamcinolone diacetate Phase 4,Phase 2
37 Triamcinolone hexacetonide Phase 4,Phase 2
38 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
39 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
41 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
45 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Sodium Channel Blockers Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
49 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
50 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 2164)

id Name Status NCT ID Phase Drugs
1 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
2 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
3 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
4 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
5 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
6 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
7 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
8 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
9 Nutrition for Colorectal Cancer Patients and Neutrophil Functions Completed NCT01831310 Phase 4
10 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy
11 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
12 Postoperative Folfox4 Only Versus Folfox4 Plus Transhepatic Arterial Chemotherapy (TAC) in the Treatment Unresectable Liver Metastasis of Colorectal Cancer Completed NCT00869271 Phase 4
13 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
14 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
15 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
16 Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants Completed NCT00138060 Phase 4 irinotecan;5 fluorouracil
17 Comparison of Two Methods of Administration of a PEG Solution Completed NCT00626054 Phase 4 PEG solution in a single dose of 3 liters;PEG solution
18 IVICA: Intravenous Iron in Colorectal Cancer Associated Anaemia Completed NCT01701310 Phase 4 Ferric carboxymaltose;Ferrous Sulphate
19 Intravenous Iron: Measuring Response in Anemic Surgical Patients Completed NCT02057471 Phase 4 Intravenous ferric carboxymaltose
20 Trial of Patient Navigation-Activation Completed NCT00496678 Phase 4
21 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
22 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
23 Health Economic Evaluation of Primovist-enhanced Liver MRI Completed NCT00764621 Phase 4
24 Impact of Probiotics on the Intestinal Microbiota Completed NCT01609660 Phase 4
25 MR Colonography With Fecal Tagging. Barium vs. BariumFerumoxsil Completed NCT00332943 Phase 4
26 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
27 Medium Calorie Parenteral Nutrition on Patients With Gastrointestinal Cancer Undergoing Surgery Completed NCT01700062 Phase 4
28 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
29 Influence of an Oral Nutritional Supplement Rich in Omega-3 Fatty Acids on Functional State and Quality of Life in Malnourished Patients With Gastroenterological Tumors Completed NCT00168987 Phase 4 oral nutritional supplement rich in eicosapentanoic acid
30 The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway Completed NCT00755729 Phase 4
31 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
32 Intraocular Bevacizumab (Avastin) for Rubeosis Iridis Completed NCT00557232 Phase 4 bevacizumab
33 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4 Ertapenem
34 Intravenous Iron for Correction of Anaemia After Colorectal Surgery Recruiting NCT02999217 Phase 4 Iron isomaltoside;Saline
35 The Efficacy of Silymarin as Adjuvant Therapy on Colorectal Cancer Patients Undergoing FOLFIRI Treatment Recruiting NCT03130634 Phase 4 Silymarin
36 Efficacy and Safety of Raltitrexed-based Transarterial Chemoembolisation(TACE)for Colorectal Cancer Liver Metastases Recruiting NCT01959061 Phase 4 Raltitrexed;Oxaliplatin;lipiodol
37 Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients Active, not recruiting NCT01271582 Phase 4 Irinotecan, 5FU, leucovorin
38 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Active, not recruiting NCT01315990 Phase 4 FOLFIRI + Cetuximab
39 Correlation Between RECIST, Morphologic Response by CT- Histopathologic Response in Hepatic Metastasis Secondary to Colorectal Cancer Active, not recruiting NCT01493713 Phase 4
40 Elaboration of a Model for Predicting Efficacy of Monoclonal Antibodies (Cetuximab and Bevacizumab) in Patients With Colorectal Cancer and Liver Metastases Terminated NCT00327093 Phase 4 cetuximab;bevacizumab
41 Assessment and Tracking of Long-term Alefacept Safety Terminated NCT00454701 Phase 4 Alefacept exposure
42 Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy In Subjects With Advanced Colorectal Cancer Terminated NCT00380874 Phase 4 Pregabalin;Placebo
43 A Phase 4 Study of Regorafenib in Metastatic Colorectal Cancer - Does Educating Physicians Change Patient Out Comes? Terminated NCT02287025 Phase 4 Regorafenib (Stivarga, BAY 73-4506)
44 Radial Reload Laparoscopic LAR Case Series Terminated NCT01706822 Phase 4
45 A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting Terminated NCT00418678 Phase 4 Cesamet
46 Ischemic Conditioning (Delay Phenomenon) in Colorectal Surgery Terminated NCT00887497 Phase 4
47 Comparison of Bowel Preparation in Virtual Colonoscopy (VC) - Patient Experience Withdrawn NCT00460837 Phase 4 bowel preparation: senna & gastrofin versus picolax (standard)
48 Acetylsalicylic Acid and Colorectal Cancer Prevention: Exploring the Platelet Function of Its Mechanism of Action Unknown status NCT02125409 Phase 3 Acetylsalicylic acid
49 Cap+Bev vs Cap+Iri+Bev 1st-line Therapy in mCRC Unknown status NCT01249638 Phase 3 Capecitabine;Bevacizumab;Capecitabine;Irinotecan;Bevacizumab
50 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin

Search NIH Clinical Center for Colorectal Cancer 1

Genetic Tests for Colorectal Cancer 1

Genetic tests related to Colorectal Cancer 1:

id Genetic test Affiliating Genes
1 Colorectal Cancer 1 29

Anatomical Context for Colorectal Cancer 1

MalaCards organs/tissues related to Colorectal Cancer 1:

39
Liver, Colon, Lung, Testes, Prostate, T Cells, Skin

Publications for Colorectal Cancer 1

Articles related to Colorectal Cancer 1:

id Title Authors Year
1
appendix 4: Metastatic colorectal cancer (1): eUpdate published online September 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). ( 27664252 )
2016
2
Prophylaxis for Venous Thromboembolism After Laparoscopic Surgery for Colorectal Cancer: 1 Week or 4 Week? ( 24887974 )
2014
3
Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study. ( 15570086 )
2004
4
Symposium on colorectal cancer. 1. Pathology of colorectal cancer. ( 647507 )
1978

Variations for Colorectal Cancer 1

UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer 1:

71
id Symbol AA change Variation ID SNP ID
1 GALNT12 p.Arg297Trp VAR_064357 rs149726976
2 GALNT12 p.Asp303Asn VAR_064358 rs145236923
3 GALNT12 p.Glu341Asp VAR_064359
4 GALNT12 p.Arg373His VAR_064360
5 GALNT12 p.Arg382His VAR_064361 rs868590153
6 GALNT12 p.Cys479Phe VAR_064362
7 GALNT12 p.Thr491Met VAR_064363 rs267606840
8 GALNT12 p.Tyr396Cys VAR_068509

ClinVar genetic disease variations for Colorectal Cancer 1:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GALNT12 NM_024642.4(GALNT12): c.3G> A (p.Met1Ile) single nucleotide variant risk factor rs267606839 GRCh37 Chromosome 9, 101569983: 101569983
2 GALNT12 NM_024642.4(GALNT12): c.1472C> T (p.Thr491Met) single nucleotide variant risk factor rs267606840 GRCh37 Chromosome 9, 101608272: 101608272
3 GALNT12 GALNT12, TYR395TER undetermined variant risk factor

Cosmic variations for Colorectal Cancer 1:

9 (show top 50) (show all 79)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10957 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 4
2 COSM45138 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 4
3 COSM43535 TP53 large intestine,colon,adenoma,NS c.391A>C p.N131H 4
4 COSM10663 TP53 large intestine,colon,adenoma,NS c.916C>T p.R306* 4
5 COSM6932 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 4
6 COSM45076 TP53 large intestine,rectum,adenoma,NS c.432G>C p.Q144H 4
7 COSM43606 TP53 large intestine,rectum,adenoma,NS c.734G>A p.G245D 4
8 COSM10870 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 4
9 COSM10648 TP53 large intestine,rectum,adenoma,NS c.524G>A p.R175H 4
10 COSM21355 STK11 large intestine,rectum,adenoma,NS c.842C>T p.P281L 4
11 COSM21354 STK11 large intestine,colon,adenoma,NS c.511G>A p.G171S 4
12 COSM14240 SMAD4 large intestine,colon,adenoma,NS c.988G>C p.E330Q 4
13 COSM14241 SMAD4 large intestine,colon,adenoma,NS c.1064A>C p.D355A 4
14 COSM5985099 RB1 large intestine,rectum,adenoma,NS c.1644A>C p.K548N 4
15 COSM569 NRAS large intestine,colon,adenoma,NS c.37G>C p.G13R 4
16 COSM584 NRAS large intestine,rectum,adenoma,NS c.182A>G p.Q61R 4
17 COSM532 KRAS large intestine,rectum,adenoma,NS c.38G>A p.G13D 4
18 COSM521 KRAS large intestine,rectum,adenoma,NS c.35G>A p.G12D 4
19 COSM520 KRAS large intestine,rectum,adenoma,NS c.35G>T p.G12V 4
20 COSM517 KRAS large intestine,colon,adenoma,NS c.34G>A p.G12S 4
21 COSM516 KRAS large intestine,colon,adenoma,NS c.34G>T p.G12C 4
22 COSM522 KRAS large intestine,colon,adenoma,NS c.35G>C p.G12A 4
23 COSM518 KRAS large intestine,colon,adenoma,NS c.34G>C p.G12R 4
24 COSM553 KRAS large intestine,rectum,adenoma,NS c.182A>T p.Q61L 4
25 COSM554 KRAS large intestine,rectum,adenoma,NS c.183A>C p.Q61H 4
26 COSM27887 GNAS large intestine,rectum,adenoma,NS c.601C>T p.R201C 4
27 COSM27895 GNAS large intestine,colon,adenoma,NS c.602G>A p.R201H 4
28 COSM25812 FBXW7 large intestine,colon,adenoma,NS c.1514G>A p.R505H 4
29 COSM22975 FBXW7 large intestine,rectum,adenoma,NS c.1513C>T p.R505C 4
30 COSM30598 FBXW7 large intestine,colon,adenoma,NS c.1558G>A p.D520N 4
31 COSM22971 FBXW7 large intestine,colon,adenoma,NS c.832C>T p.R278* 4
32 COSM30597 FBXW7 large intestine,rectum,adenoma,NS c.892C>T p.P298S 4
33 COSM22965 FBXW7 large intestine,colon,adenoma,NS c.1394G>A p.R465H 4
34 COSM21689 EGFR large intestine,colon,adenoma,NS c.1787C>T p.P596L 4
35 COSM5667 CTNNB1 large intestine,colon,adenoma,NS c.134C>T p.S45F 4
36 COSM5663 CTNNB1 large intestine,colon,adenoma,NS c.133T>C p.S45P 4
37 COSM5687 CTNNB1 large intestine,rectum,adenoma,NS c.109T>C p.S37P 4
38 COSM5671 CTNNB1 large intestine,colon,adenoma,NS c.101G>A p.G34E 4
39 COSM5664 CTNNB1 large intestine,colon,adenoma,NS c.121A>G p.T41A 4
40 COSM476 BRAF large intestine,colon,adenoma,NS c.1799T>A p.V600E 4
41 COSM467 BRAF large intestine,colon,adenoma,NS c.1781A>G p.D594G 4
42 COSM21492 BRAF large intestine,colon,adenoma,NS c.1357C>A p.P453T 4
43 COSM21493 BRAF large intestine,colon,adenoma,NS c.1766C>T p.T589I 4
44 COSM18942 APC large intestine,colon,adenoma,NS c.3928A>T p.K1310* 4
45 COSM18834 APC large intestine,colon,adenoma,NS c.4135G>T p.E1379* 4
46 COSM13121 APC large intestine,colon,adenoma,NS c.4099C>T p.Q1367* 4
47 COSM19056 APC large intestine,colon,adenoma,NS c.4606G>T p.E1536* 4
48 COSM19241 APC large intestine,rectum,adenoma,NS c.4067C>A p.S1356* 4
49 COSM13127 APC large intestine,colon,adenoma,NS c.4348C>T p.R1450* 4
50 COSM5023003 APC large intestine,colon,adenoma,NS c.3796G>A p.D1266N 4

Expression for Colorectal Cancer 1

Search GEO for disease gene expression data for Colorectal Cancer 1.

Pathways for Colorectal Cancer 1

Pathways related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
2
Show member pathways
13.73 GALNT12 MUC1 MUC12 MUC13 MUC15 MUC16
3
Show member pathways
13.69 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
4
Show member pathways
12.52 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
5
Show member pathways
12.5 GALNT12 MUC1 MUC12 MUC13 MUC15 MUC16
6
Show member pathways
11.95 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
7
Show member pathways
11.74 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17

GO Terms for Colorectal Cancer 1

Cellular components related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 MUC1 MUC13 MUC15 MUC16 MUC17 MUC20
2 plasma membrane GO:0005886 9.91 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
3 apical plasma membrane GO:0016324 9.62 MUC1 MUC13 MUC17 MUC20
4 Golgi lumen GO:0005796 9.58 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
5 mucus layer GO:0070701 9.26 MUC5AC MUC5B
6 extracellular exosome GO:0070062 10.02 MUC1 MUC13 MUC16 MUC19 MUC21 MUC4

Biological processes related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 9.93 GALNT12 MUC1 MUC12 MUC13 MUC15 MUC16
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.58 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17
3 maintenance of gastrointestinal epithelium GO:0030277 9.46 MUC13 MUC2 MUC4 MUC6

Molecular functions related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.13 MUC3A MUC5AC MUC6
2 extracellular matrix constituent, lubricant activity GO:0030197 8.8 MUC17 MUC3A MUC4

Sources for Colorectal Cancer 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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42 MeSH
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59 PubMed
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67 TGDB
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