MCID: CLR079
MIFTS: 30

Colorectal Cancer 2

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 2

MalaCards integrated aliases for Colorectal Cancer 2:

Name: Colorectal Cancer 2 54 29
Colorectal Cancer, Susceptibility to, 2 13

Classifications:



External Ids:

OMIM 54 611469

Summaries for Colorectal Cancer 2

MalaCards based summary : Colorectal Cancer 2, also known as colorectal cancer, susceptibility to, 2, is related to colorectal cancer, hereditary nonpolyposis, type 2 and colorectal cancer. An important gene associated with Colorectal Cancer 2 is CRCS2 (Colorectal Cancer, Susceptibility To, 2). The drugs Lidocaine and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and lung, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Description from OMIM: 611469

Related Diseases for Colorectal Cancer 2

Symptoms & Phenotypes for Colorectal Cancer 2

Clinical features from OMIM:

611469

GenomeRNAi Phenotypes related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.65 MLH1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.65 MLH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.65 TK1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.65 MLH1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.65 TK1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.65 TK1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.65 MLH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.65 MLH1 TK1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.65 TK1
10 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.62 MLH1 TK1

Drugs & Therapeutics for Colorectal Cancer 2

Drugs for Colorectal Cancer 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 679)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
2
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 5310940 9887054 43805 6857599
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
5
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
6
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
7
Levoleucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1 68538-85-2
8
Bisacodyl Approved Phase 4 603-50-9
9
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
10
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
11
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
12
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
13
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
14
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2 112887-68-0 104758
15 Magnesium citrate Approved Phase 4,Phase 3
16
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
17
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
18
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
19
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
20
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
21
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
22
Ethiodized oil Approved Phase 4,Phase 2 8008-53-5
23
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
24
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
26
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 143 6006
27 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
28
Menadione Approved, Nutraceutical Phase 4,Phase 2,Phase 1 58-27-5 4055
29
Phytonadione Approved, Nutraceutical Phase 4,Phase 2,Phase 1 84-80-0 4812 5284607
30
Iodine Investigational Phase 4,Phase 1 7553-56-2 807
31
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1 7689-03-4
32 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
33 Anesthetics, Local Phase 4,Phase 2,Phase 1
34 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 1,Phase 2
35 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
36 Diuretics, Potassium Sparing Phase 4,Phase 1,Phase 2
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Sodium Channel Blockers Phase 4,Phase 1,Phase 2
39 Antidotes Phase 4,Phase 2,Phase 3,Phase 1
40 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
41 Antimetabolites, Antineoplastic Phase 4,Phase 2,Phase 3,Phase 1
42 cadexomer iodine Phase 4,Phase 1
43 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
44 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
47 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 triamcinolone acetonide Phase 4,Phase 2
49 Triamcinolone diacetate Phase 4,Phase 2
50 Triamcinolone hexacetonide Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 2361)

id Name Status NCT ID Phase Drugs
1 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
2 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
3 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
4 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
5 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
6 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
7 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
8 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
9 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4 polyethylene glycol
10 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
11 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
12 A Multi-centre Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate) Completed NCT01689792 Phase 4 MOVIPREP;CitraFleet
13 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
14 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
15 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4 Capecitabine
16 Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum Completed NCT01175317 Phase 4
17 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy
18 Postoperative Folfox4 Only Versus Folfox4 Plus Transhepatic Arterial Chemotherapy (TAC) in the Treatment Unresectable Liver Metastasis of Colorectal Cancer Completed NCT00869271 Phase 4
19 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
20 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
21 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
22 Comparison of Two Methods of Administration of a PEG Solution Completed NCT00626054 Phase 4 PEG solution in a single dose of 3 liters;PEG solution
23 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
24 Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants Completed NCT00138060 Phase 4 irinotecan;5 fluorouracil
25 Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery Completed NCT00488904 Phase 4
26 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
27 Health Economic Evaluation of Primovist-enhanced Liver MRI Completed NCT00764621 Phase 4
28 Impact of Probiotics on the Intestinal Microbiota Completed NCT01609660 Phase 4
29 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
30 Magnetic Resonance (MR) Colonography With Fecal Tagging Completed NCT00114842 Phase 4
31 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4 Capecitabine
32 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
33 Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection Completed NCT01887158 Phase 4 Polyethylene glycol;Bisacodyl
34 Preoperative Non-steroidal Anti-inflammatory Drugs(NSAID) to Colorectal Cancer Patients Completed NCT00473980 Phase 4 Indomethacin, celecoxib, esomeprazole
35 Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery Completed NCT01075646 Phase 4 ropivacaine;saline solution
36 Resection vs no Resection of the Primary in Colorectal Cancer With Unresectable Metastases Recruiting NCT02015923 Phase 4 Chemotherapy- scheme
37 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Recruiting NCT02557490 Phase 4 oxaliplatin and raltitrexed
38 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Active, not recruiting NCT01315990 Phase 4 FOLFIRI + Cetuximab
39 Maintenance Treatment With Capecitabine Metronomic Chemotherapy and Chinese Traditional Medicine in Metastatic Colorectal Cancer Active, not recruiting NCT02575378 Phase 4 Metronimic chemotherapy plus Chinese Traditional Medicine;Metronimic chemotherapy
40 Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia Active, not recruiting NCT02032953 Phase 4 Insulin
41 Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients Active, not recruiting NCT01271582 Phase 4 Irinotecan, 5FU, leucovorin
42 Correlation Between RECIST, Morphologic Response by CT- Histopathologic Response in Hepatic Metastasis Secondary to Colorectal Cancer Active, not recruiting NCT01493713 Phase 4
43 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Not yet recruiting NCT02746432 Phase 4 Hyper insulinemic euglycemic clamp
44 Comparative Effectiveness of Split-Dose Colonoscopy Bowel Preparation Regimens Not yet recruiting NCT03298945 Phase 4 Miralax-Gatorade Prep;Golytely
45 Elaboration of a Model for Predicting Efficacy of Monoclonal Antibodies (Cetuximab and Bevacizumab) in Patients With Colorectal Cancer and Liver Metastases Terminated NCT00327093 Phase 4 cetuximab;bevacizumab
46 Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy In Subjects With Advanced Colorectal Cancer Terminated NCT00380874 Phase 4 Pregabalin;Placebo
47 Radial Reload Laparoscopic LAR Case Series Terminated NCT01706822 Phase 4
48 Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)
49 A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting Terminated NCT00418678 Phase 4 Cesamet
50 Ischemic Conditioning (Delay Phenomenon) in Colorectal Surgery Terminated NCT00887497 Phase 4

Search NIH Clinical Center for Colorectal Cancer 2

Genetic Tests for Colorectal Cancer 2

Genetic tests related to Colorectal Cancer 2:

id Genetic test Affiliating Genes
1 Colorectal Cancer 2 29

Anatomical Context for Colorectal Cancer 2

MalaCards organs/tissues related to Colorectal Cancer 2:

39
Liver, Colon, Lung, Testes, Prostate, Skin, T Cells

Publications for Colorectal Cancer 2

Articles related to Colorectal Cancer 2:

id Title Authors Year
1
appendix 5: Metastatic colorectal cancer (2): eUpdate published online August 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). ( 27664253 )
2016
2
Colorectal cancer: 2 steps backward. ( 19820071 )
2009

Variations for Colorectal Cancer 2

Expression for Colorectal Cancer 2

Search GEO for disease gene expression data for Colorectal Cancer 2.

Pathways for Colorectal Cancer 2

GO Terms for Colorectal Cancer 2

Sources for Colorectal Cancer 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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