MCID: CLR079
MIFTS: 29

Colorectal Cancer 2 malady

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 2

Aliases & Descriptions for Colorectal Cancer 2:

Name: Colorectal Cancer 2 54 29
Colorectal Cancer, Susceptibility to, 2 13

Classifications:



External Ids:

OMIM 54 611469

Summaries for Colorectal Cancer 2

MalaCards based summary : Colorectal Cancer 2, also known as colorectal cancer, susceptibility to, 2, is related to colorectal cancer and colorectal cancer, hereditary nonpolyposis, type 2. An important gene associated with Colorectal Cancer 2 is CRCS2 (Colorectal Cancer, Susceptibility To, 2). The drugs Lidocaine and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include appendix, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Description from OMIM: 611469

Related Diseases for Colorectal Cancer 2

Symptoms & Phenotypes for Colorectal Cancer 2

Clinical features from OMIM:

611469

GenomeRNAi Phenotypes related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.65 MLH1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.65 MLH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.65 TK1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.65 MLH1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.65 TK1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.65 TK1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.65 MLH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.65 MLH1 TK1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.65 TK1
10 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.62 MLH1 TK1

Drugs & Therapeutics for Colorectal Cancer 2

Drugs for Colorectal Cancer 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 776)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
2
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
5
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
6
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
7
Levoleucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1 68538-85-2
8
Bisacodyl Approved Phase 4 603-50-9
9
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
10
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
11
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
12
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
13
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
15
Epirubicin Approved Phase 4,Phase 3,Phase 1,Phase 2 56420-45-2 41867
16
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2 112887-68-0 104758
17
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
18
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
19
Hydromorphone Approved, Illicit Phase 4,Phase 2 466-99-9 5284570
20
Ketorolac Approved Phase 4,Phase 2 74103-06-3, 66635-83-4 3826
21
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
22
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
23
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
24
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
25
Magnesium oxide Approved Phase 4,Phase 2 1309-48-4 14792
26
Sodium sulfate Approved, Vet_approved Phase 4,Phase 2,Phase 1 7757-82-6
27
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
28 Parecoxib Approved Phase 4 198470-84-7
29
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
30
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
31
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
32
Sulfamethoxazole Approved Phase 4 723-46-6 5329
33
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
34
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
35
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
36
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516
37
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
38
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
39
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
40
Sufentanil Approved, Investigational Phase 4,Phase 3 56030-54-7 41693
41
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 99011-02-6 57469
42
Ethiodized oil Approved Phase 4 8008-53-5
43
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
44
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
45
Methadone Approved Phase 4 76-99-3 4095
46
Orphenadrine Approved Phase 4 83-98-7 4601
47
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
48
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
50
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 54575, 6560146 143

Interventional clinical trials:

(show top 50) (show all 2980)
id Name Status NCT ID Phase
1 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4
2 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
3 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4
4 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4
5 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4
6 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4
7 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4
8 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
9 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4
10 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
11 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4
12 A Multi-centre Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate) Completed NCT01689792 Phase 4
13 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4
14 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4
15 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4
16 Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum Completed NCT01175317 Phase 4
17 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4
18 Postoperative Folfox4 Only Versus Folfox4 Plus Transhepatic Arterial Chemotherapy (TAC) in the Treatment Unresectable Liver Metastasis of Colorectal Cancer Completed NCT00869271 Phase 4
19 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
20 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4
21 Comparison of Two Methods of Administration of a PEG Solution Completed NCT00626054 Phase 4
22 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4
23 Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants Completed NCT00138060 Phase 4
24 Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery Completed NCT00488904 Phase 4
25 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4
26 Health Economic Evaluation of Primovist-enhanced Liver MRI Completed NCT00764621 Phase 4
27 Impact of Probiotics on the Intestinal Microbiota Completed NCT01609660 Phase 4
28 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4
29 Magnetic Resonance (MR) Colonography With Fecal Tagging Completed NCT00114842 Phase 4
30 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4
31 A Translational Study of Avastin (Bevacizumab) in Patients With Metastatic Colorectal Cancer (ASCENT) Completed NCT01588990 Phase 4
32 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4
33 Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection Completed NCT01887158 Phase 4
34 Preoperative Non-steroidal Anti-inflammatory Drugs(NSAID) to Colorectal Cancer Patients Completed NCT00473980 Phase 4
35 Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery Completed NCT01075646 Phase 4
36 Optimisation and Performance of Reduced Preparation CT Colography Completed NCT00212433 Phase 4
37 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
38 SurgiWrapTM to Reduce Soft Tissue Attachment & Incidence Early Post-Operative Bowel Obstruction in Colorectal Surgery Completed NCT00531739 Phase 4
39 Endo-Laparoscopic Approach Versus Conventional Open Surgery in Obstructing Left-sided Colon Cancer: RCT Completed NCT00654212 Phase 4
40 Clinical Evaluation of Narrow Band Imaging Colonoscope Completed NCT00628147 Phase 4
41 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4
42 Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid. Completed NCT02073552 Phase 4
43 MASCOT : Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4
44 Effect of Parecoxib Sodium and Flurbiprofen Injection on Postoperative Shivering Completed NCT02569905 Phase 4
45 The Effect of Dexmedetomidine on Postoperative Analgesia Completed NCT01373021 Phase 4
46 Orally Administered Trimethoprim-sulfamethoxazole and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery Completed NCT00613769 Phase 4
47 Prospective Observational Study of 1st and 2nd Line Vectibix® Use in RAS-wt mCRC Pts to Evaluate Pattern of Use and ORR Recruiting NCT02322736 Phase 4
48 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Recruiting NCT02746432 Phase 4
49 Resection vs no Resection of the Primary in Colorectal Cancer With Unresectable Metastases Recruiting NCT02015923 Phase 4
50 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Recruiting NCT02557490 Phase 4

Search NIH Clinical Center for Colorectal Cancer 2

Genetic Tests for Colorectal Cancer 2

Genetic tests related to Colorectal Cancer 2:

id Genetic test Affiliating Genes
1 Colorectal Cancer 2 29

Anatomical Context for Colorectal Cancer 2

MalaCards organs/tissues related to Colorectal Cancer 2:

39
Appendix

Publications for Colorectal Cancer 2

Articles related to Colorectal Cancer 2:

id Title Authors Year
1
appendix 5: Metastatic colorectal cancer (2): eUpdate published online August 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). ( 27664253 )
2016
2
Colorectal cancer: 2 steps backward. ( 19820071 )
2009

Variations for Colorectal Cancer 2

Expression for Colorectal Cancer 2

Search GEO for disease gene expression data for Colorectal Cancer 2.

Pathways for Colorectal Cancer 2

GO Terms for Colorectal Cancer 2

Sources for Colorectal Cancer 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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