MCID: CLR079
MIFTS: 20

Colorectal Cancer 2

Categories: Rare diseases, Gastrointestinal diseases, Genetic diseases, Cancer diseases

Aliases & Classifications for Colorectal Cancer 2

MalaCards integrated aliases for Colorectal Cancer 2:

Name: Colorectal Cancer 2 53 28
Colorectal Cancer, Susceptibility to, 2 53 13
Colorectal Cancer, Susceptibility to, on Chromosome 8q24 53
Colorectal Cancer on Chromosome 8q24 53
Crcs2 53

Classifications:



External Ids:

OMIM 53 611469

Summaries for Colorectal Cancer 2

MalaCards based summary : Colorectal Cancer 2, also known as colorectal cancer, susceptibility to, 2, is related to colorectal cancer, hereditary nonpolyposis, type 2 and colorectal cancer. An important gene associated with Colorectal Cancer 2 is CRCS2 (Colorectal Cancer, Susceptibility To, 2). Affiliated tissues include appendix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 611469

Related Diseases for Colorectal Cancer 2

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer, hereditary nonpolyposis, type 2 11.6
2 colorectal cancer 9.8

Symptoms & Phenotypes for Colorectal Cancer 2

Clinical features from OMIM:

611469

GenomeRNAi Phenotypes related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

25 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.85 MLH1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.85 MLH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.85 TK1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.85 MLH1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.85 TK1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.85 TK1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.85 MLH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.85 MLH1 TK1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.85 TK1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.73 DNMT1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.73 MLH1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.73 MLH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.73 DNMT1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.73 DNMT1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.73 MLH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.73 DNMT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.73 DNMT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.73 MLH1 DNMT1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.73 MLH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.73 MLH1
21 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 DNMT1 MLH1 TK1

MGI Mouse Phenotypes related to Colorectal Cancer 2:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 DNMT1 MLH1 TK1

Drugs & Therapeutics for Colorectal Cancer 2

Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 2

Genetic Tests for Colorectal Cancer 2

Genetic tests related to Colorectal Cancer 2:

# Genetic test Affiliating Genes
1 Colorectal Cancer 2 28

Anatomical Context for Colorectal Cancer 2

MalaCards organs/tissues related to Colorectal Cancer 2:

38
Appendix

Publications for Colorectal Cancer 2

Articles related to Colorectal Cancer 2:

# Title Authors Year
1
appendix 5: Metastatic colorectal cancer (2): eUpdate published online August 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). ( 27664253 )
2016
2
Colorectal cancer: 2 steps backward. ( 19820071 )
2009

Variations for Colorectal Cancer 2

Expression for Colorectal Cancer 2

Search GEO for disease gene expression data for Colorectal Cancer 2.

Pathways for Colorectal Cancer 2

GO Terms for Colorectal Cancer 2

Sources for Colorectal Cancer 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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