MCID: CLR075
MIFTS: 29

Colorectal Cancer 3

Categories: Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 3

MalaCards integrated aliases for Colorectal Cancer 3:

Name: Colorectal Cancer 3 54 71 29
Susceptibility to Colorectal Cancer on Chromosome 18 71
Colorectal Cancer, Susceptibility to, 3 13
Crcs3 71

Characteristics:

HPO:

32
colorectal cancer 3:
Inheritance heterogeneous


Classifications:



External Ids:

OMIM 54 612229
MedGen 40 C2677123
MeSH 42 D015179
SNOMED-CT via HPO 65 363406005

Summaries for Colorectal Cancer 3

UniProtKB/Swiss-Prot : 71 Colorectal cancer 3: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

MalaCards based summary : Colorectal Cancer 3, also known as susceptibility to colorectal cancer on chromosome 18, is related to colorectal cancer, hereditary nonpolyposis, type 1 and colorectal cancer, and has symptoms including colon cancer An important gene associated with Colorectal Cancer 3 is SMAD7 (SMAD Family Member 7). The drugs Fluorouracil and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung.

Description from OMIM: 612229

Related Diseases for Colorectal Cancer 3

Symptoms & Phenotypes for Colorectal Cancer 3

Clinical features from OMIM:

612229

Human phenotypes related to Colorectal Cancer 3:

32
id Description HPO Frequency HPO Source Accession
1 colon cancer 32 HP:0003003

Drugs & Therapeutics for Colorectal Cancer 3

Drugs for Colorectal Cancer 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 612)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
2
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
3
Tegafur Approved Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7 5386
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
5
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
6
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
7
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
8
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
9
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2 112887-68-0 104758
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
11
Benzocaine Approved Phase 4,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
12
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
13
Octreotide Approved, Investigational Phase 4,Phase 3 83150-76-9 383414 6400441
14
Epirubicin Approved Phase 4,Phase 3 56420-45-2 41867
15
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
16
Ethiodized oil Approved Phase 4,Phase 2 8008-53-5
17
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
18
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054
19
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
20
Iron Approved Phase 4,Phase 3 7439-89-6 23925
21
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
24 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 1
25 Tocopherol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
26
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-02-9 14985
27
Iodine Investigational Phase 4,Phase 3,Phase 1 7553-56-2 807
28
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1 7689-03-4
29 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Antidotes Phase 4,Phase 3,Phase 2,Phase 1
31 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
32 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
33 cadexomer iodine Phase 4,Phase 3,Phase 1
34 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 triamcinolone acetonide Phase 4,Phase 2
39 Triamcinolone diacetate Phase 4,Phase 2
40 Triamcinolone hexacetonide Phase 4,Phase 2
41 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
42 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
44 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
45 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
46 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
48 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 calcium heparin Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1664)

id Name Status NCT ID Phase Drugs
1 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
2 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
3 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
4 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
5 Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery Completed NCT00488904 Phase 4
6 Nutrition for Colorectal Cancer Patients and Neutrophil Functions Completed NCT01831310 Phase 4
7 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
8 Postoperative Folfox4 Only Versus Folfox4 Plus Transhepatic Arterial Chemotherapy (TAC) in the Treatment Unresectable Liver Metastasis of Colorectal Cancer Completed NCT00869271 Phase 4
9 Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer Completed NCT00928928 Phase 4
10 The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway Completed NCT00755729 Phase 4
11 Comparison of Two Methods of Administration of a PEG Solution Completed NCT00626054 Phase 4 PEG solution in a single dose of 3 liters;PEG solution
12 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
13 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
14 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
15 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4 Capecitabine
16 Influence of an Oral Nutritional Supplement Rich in Omega-3 Fatty Acids on Functional State and Quality of Life in Malnourished Patients With Gastroenterological Tumors Completed NCT00168987 Phase 4 oral nutritional supplement rich in eicosapentanoic acid
17 Health Economic Evaluation of Primovist-enhanced Liver MRI Completed NCT00764621 Phase 4
18 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy
19 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
20 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
21 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4 PEG-rhG-CSF
22 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
23 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
24 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
25 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4 Capecitabine
26 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
27 STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea Completed NCT00050635 Phase 4 Sandostatin LAR Depot
28 The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib Recruiting NCT02800330 Phase 4 Esomeprazole 40mg concomitantly;Esomeprazole 40mg before;Regorafenib 160mg or 120mg
29 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Recruiting NCT02557490 Phase 4 oxaliplatin and raltitrexed
30 Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis? Recruiting NCT01740947 Phase 4 Selective decontamination of the digestive tract (SDD) (colistin sulfate, tobramycin, amphotericin B)
31 Intravenous Iron for Correction of Anaemia After Colorectal Surgery Recruiting NCT02999217 Phase 4 Iron isomaltoside;Saline
32 Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients Active, not recruiting NCT01271582 Phase 4 Irinotecan, 5FU, leucovorin
33 Correlation Between RECIST, Morphologic Response by CT- Histopathologic Response in Hepatic Metastasis Secondary to Colorectal Cancer Active, not recruiting NCT01493713 Phase 4
34 Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function Active, not recruiting NCT02231203 Phase 4 Omegaven;Placebo
35 Study to Assess the Effectiveness of a Omega-3 Enriched Supplement on Chemotherapy Tolerance in Colon Cancer Patients Terminated NCT00398333 Phase 4
36 A Phase 4 Study of Regorafenib in Metastatic Colorectal Cancer - Does Educating Physicians Change Patient Out Comes? Terminated NCT02287025 Phase 4 Regorafenib (Stivarga, BAY 73-4506)
37 Assessment and Tracking of Long-term Alefacept Safety Terminated NCT00454701 Phase 4 Alefacept exposure
38 Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)
39 CONCEPT: Comparison of Oxaliplatin vs Conventional Methods With Calcium/Magnesium in First-Line Metastatic Colorectal Cancer Terminated NCT00129870 Phase 4 oxaliplatin
40 Ischemic Conditioning (Delay Phenomenon) in Colorectal Surgery Terminated NCT00887497 Phase 4
41 A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting Terminated NCT00418678 Phase 4 Cesamet
42 Maintenance Treatment Versus Observation After Induction in Advanced Colorectal Carcinoma Unknown status NCT00442637 Phase 3 capecitabine + bevacizumab
43 Randomized Phase III Adjuvant Study for Stage III Colorectal Cancer Unknown status NCT00209742 Phase 3 UFT;USEL/Leucovorin;Krestin
44 A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer Unknown status NCT00385970 Phase 3 Tegafur-uracil (UFT);Calcium folinate (LV);Krestin (PSK)
45 Phase 3 Study of Surgery Combined With Neoadjuvant Chemotherapy(XELOX) in Colorectal Cancer With Resectable Liver Metastasis Unknown status NCT00630045 Phase 3 neoadjuvant chemotherapy with oxaliplatin and capecitabine
46 Effect of Enteral Nutrition Rich in Eicosapentaenoic Acid (EPA) on Patients Receiving Chemotherapy for GI Tumor Unknown status NCT01048463 Phase 3 Nutriall;LDEPA;Placebo;HDEPA;Chemotherapy
47 Combination Chemotherapy After Surgery in Treating Patients With High-Risk Stage II or Stage III Colorectal Cancer Unknown status NCT00749450 Phase 3 capecitabine;fluorouracil;oxaliplatin
48 Does Endoscope Position Detecting Unit Facilitate a Complete Colonoscopy Examination Unknown status NCT01434199 Phase 3
49 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) Unknown status NCT00433927 Phase 3 5-FU;folinic acid;irinotecan;cetuximab;bevacizumab
50 Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer Unknown status NCT00002893 Phase 3 fluorouracil;leucovorin calcium;raltitrexed

Search NIH Clinical Center for Colorectal Cancer 3

Genetic Tests for Colorectal Cancer 3

Genetic tests related to Colorectal Cancer 3:

id Genetic test Affiliating Genes
1 Colorectal Cancer 3 29

Anatomical Context for Colorectal Cancer 3

MalaCards organs/tissues related to Colorectal Cancer 3:

39
Colon, Liver, Lung, Testes, Prostate, Skin, Lymph Node

Publications for Colorectal Cancer 3

Articles related to Colorectal Cancer 3:

id Title Authors Year
1
Bcr-abl positive blast crisis of chronic myeloid leukemia emerging in a case of metastatic colorectal cancer 3 months after completion of an 8-month course of cetuximab and irinotecan. ( 16494624 )
2006

Variations for Colorectal Cancer 3

ClinVar genetic disease variations for Colorectal Cancer 3:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SMAD7 NM_005904.3(SMAD7): c.743-5183A= single nucleotide variant risk factor rs4939827 GRCh38 Chromosome 18, 48927093: 48927093

Cosmic variations for Colorectal Cancer 3:

9 (show top 50) (show all 79)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10957 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 3
2 COSM45138 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 3
3 COSM43535 TP53 large intestine,colon,adenoma,NS c.391A>C p.N131H 3
4 COSM10663 TP53 large intestine,colon,adenoma,NS c.916C>T p.R306* 3
5 COSM6932 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 3
6 COSM45076 TP53 large intestine,rectum,adenoma,NS c.432G>C p.Q144H 3
7 COSM11354 TP53 large intestine,rectum,other,ulcerative colitis c.991C>T p.Q331* 3
8 COSM43606 TP53 large intestine,rectum,adenoma,NS c.734G>A p.G245D 3
9 COSM10870 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 3
10 COSM10648 TP53 large intestine,rectum,adenoma,NS c.524G>A p.R175H 3
11 COSM21355 STK11 large intestine,rectum,adenoma,NS c.842C>T p.P281L 3
12 COSM21354 STK11 large intestine,colon,adenoma,NS c.511G>A p.G171S 3
13 COSM14240 SMAD4 large intestine,colon,adenoma,NS c.988G>C p.E330Q 3
14 COSM14241 SMAD4 large intestine,colon,adenoma,NS c.1064A>C p.D355A 3
15 COSM14143 SMAD4 large intestine,rectum,other,ulcerative colitis c.1546C>T p.Q516* 3
16 COSM5985099 RB1 large intestine,rectum,adenoma,NS c.1644A>C p.K548N 3
17 COSM569 NRAS large intestine,colon,adenoma,NS c.37G>C p.G13R 3
18 COSM584 NRAS large intestine,rectum,adenoma,NS c.182A>G p.Q61R 3
19 COSM532 KRAS large intestine,rectum,adenoma,NS c.38G>A p.G13D 3
20 COSM521 KRAS large intestine,rectum,adenoma,NS c.35G>A p.G12D 3
21 COSM520 KRAS large intestine,rectum,adenoma,NS c.35G>T p.G12V 3
22 COSM517 KRAS large intestine,colon,adenoma,NS c.34G>A p.G12S 3
23 COSM516 KRAS large intestine,colon,adenoma,NS c.34G>T p.G12C 3
24 COSM522 KRAS large intestine,colon,adenoma,NS c.35G>C p.G12A 3
25 COSM518 KRAS large intestine,colon,adenoma,NS c.34G>C p.G12R 3
26 COSM553 KRAS large intestine,rectum,adenoma,NS c.182A>T p.Q61L 3
27 COSM528 KRAS large intestine,colon,other,ulcerative colitis c.37G>A p.G13S 3
28 COSM554 KRAS large intestine,rectum,adenoma,NS c.183A>C p.Q61H 3
29 COSM27887 GNAS large intestine,rectum,adenoma,NS c.601C>T p.R201C 3
30 COSM27895 GNAS large intestine,colon,adenoma,NS c.602G>A p.R201H 3
31 COSM25812 FBXW7 large intestine,colon,adenoma,NS c.1514G>A p.R505H 3
32 COSM22975 FBXW7 large intestine,rectum,adenoma,NS c.1513C>T p.R505C 3
33 COSM30598 FBXW7 large intestine,colon,adenoma,NS c.1558G>A p.D520N 3
34 COSM22971 FBXW7 large intestine,colon,adenoma,NS c.832C>T p.R278* 3
35 COSM30597 FBXW7 large intestine,rectum,adenoma,NS c.892C>T p.P298S 3
36 COSM22965 FBXW7 large intestine,colon,adenoma,NS c.1394G>A p.R465H 3
37 COSM21689 EGFR large intestine,colon,adenoma,NS c.1787C>T p.P596L 3
38 COSM5667 CTNNB1 large intestine,colon,adenoma,NS c.134C>T p.S45F 3
39 COSM5663 CTNNB1 large intestine,colon,adenoma,NS c.133T>C p.S45P 3
40 COSM5687 CTNNB1 large intestine,rectum,adenoma,NS c.109T>C p.S37P 3
41 COSM5671 CTNNB1 large intestine,colon,adenoma,NS c.101G>A p.G34E 3
42 COSM5664 CTNNB1 large intestine,colon,adenoma,NS c.121A>G p.T41A 3
43 COSM476 BRAF large intestine,colon,adenoma,NS c.1799T>A p.V600E 3
44 COSM467 BRAF large intestine,colon,adenoma,NS c.1781A>G p.D594G 3
45 COSM21492 BRAF large intestine,colon,adenoma,NS c.1357C>A p.P453T 3
46 COSM21493 BRAF large intestine,colon,adenoma,NS c.1766C>T p.T589I 3
47 COSM18942 APC large intestine,colon,adenoma,NS c.3928A>T p.K1310* 3
48 COSM18834 APC large intestine,colon,adenoma,NS c.4135G>T p.E1379* 3
49 COSM13121 APC large intestine,colon,adenoma,NS c.4099C>T p.Q1367* 3
50 COSM19056 APC large intestine,colon,adenoma,NS c.4606G>T p.E1536* 3

Expression for Colorectal Cancer 3

Search GEO for disease gene expression data for Colorectal Cancer 3.

Pathways for Colorectal Cancer 3

GO Terms for Colorectal Cancer 3

Sources for Colorectal Cancer 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
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48 NDF-RT
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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