MCID: CLR080
MIFTS: 32

Colorectal Cancer 5 malady

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 5

Aliases & Descriptions for Colorectal Cancer 5:

Name: Colorectal Cancer 5 54 29
Colorectal Cancer, Susceptibility to, 5 13

Classifications:



External Ids:

OMIM 54 612230

Summaries for Colorectal Cancer 5

MalaCards based summary : Colorectal Cancer 5, also known as colorectal cancer, susceptibility to, 5, is related to colorectal cancer and colorectal cancer, hereditary nonpolyposis, type 5. An important gene associated with Colorectal Cancer 5 is CRCS5 (Colorectal Cancer, Susceptibility To, 5), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Endometrial cancer. The drugs Fluorouracil and Oxaliplatin have been mentioned in the context of this disorder.

Description from OMIM: 612230

Related Diseases for Colorectal Cancer 5

Graphical network of the top 20 diseases related to Colorectal Cancer 5:



Diseases related to Colorectal Cancer 5

Symptoms & Phenotypes for Colorectal Cancer 5

Clinical features from OMIM:

612230

Drugs & Therapeutics for Colorectal Cancer 5

Drugs for Colorectal Cancer 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 585)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
2
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
3 Tegafur Approved Phase 4,Phase 3,Phase 1,Phase 2 17902-23-7
4
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
5
Capecitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 154361-50-9 60953
6
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
7
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
8
Epirubicin Approved Phase 4,Phase 3,Phase 1,Phase 2 56420-45-2 41867
9
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Early Phase 1 437-38-7 3345
11
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1 205923-56-4 56842117 2333
12
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
13
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
14
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
15
Bisacodyl Approved Phase 4 603-50-9
16
Sodium sulfate Approved, Vet_approved Phase 4,Phase 2 7757-82-6
17
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
18
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
19
Lidocaine Approved, Vet_approved Phase 4,Early Phase 1 137-58-6 3676
20
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
21
Zinc Approved Phase 4 7440-66-6 32051 23994
22
Ethiodized oil Approved Phase 4 8008-53-5
23
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
24
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
25
Bupivacaine Approved, Investigational Phase 4,Phase 2 2180-92-9, 38396-39-3 2474
26
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
27
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
28
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
29
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
30
Methadone Approved Phase 4 76-99-3 4095
31
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
32
Orphenadrine Approved Phase 4 83-98-7 4601
33
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
34
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
35
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
37
Vitamin C Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 50-81-7 5785 54670067
38 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
39
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
40
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
41
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1 7689-03-4
42 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
44 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
49 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1526)
id Name Status NCT ID Phase
1 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4
2 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4
3 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4
4 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4
5 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
6 Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants Completed NCT00138060 Phase 4
7 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4
8 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4
9 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
10 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4
11 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4
12 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4
13 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4
14 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
15 A Translational Study of Avastin (Bevacizumab) in Patients With Metastatic Colorectal Cancer (ASCENT) Completed NCT01588990 Phase 4
16 Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery Completed NCT01075646 Phase 4
17 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4
18 MASCOT : Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4
19 Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection Completed NCT01887158 Phase 4
20 Cold Snare Versus Double Biopsy Polypectomy Technique for Removal of Diminutive Colorectal Polyps Completed NCT01646242 Phase 4
21 Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid. Completed NCT02073552 Phase 4
22 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Recruiting NCT02746432 Phase 4
23 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Recruiting NCT02557490 Phase 4
24 Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4
25 Efficacy and Safety of Raltitrexed-based Transarterial Chemoembolisation(TACE)for Colorectal Cancer Liver Metastases Recruiting NCT01959061 Phase 4
26 The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib Recruiting NCT02800330 Phase 4
27 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4
28 A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II of Colon Cancer Recruiting NCT02887365 Phase 4
29 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Recruiting NCT02056405 Phase 4
30 Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients Active, not recruiting NCT01271582 Phase 4
31 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Active, not recruiting NCT01315990 Phase 4
32 Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia Active, not recruiting NCT02032953 Phase 4
33 Hot Snare Versus Hot Snare Polypectomy With Saline Injection for Colorectal Polyps Enrolling by invitation NCT02239536 Phase 4
34 Study Comparing Optimized 5-FU Dosing and Standard Dosing in Metastatic Colorectal Cancer Patients Treated With mFOLFOX6 Terminated NCT01468623 Phase 4
35 A Study to Compare Two Avastin-Based Treatment Regimens for the Treatment of Metastatic Colorectal Cancer Terminated NCT00114946 Phase 4
36 Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4
37 A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting Terminated NCT00418678 Phase 4
38 Ischemic Conditioning (Delay Phenomenon) in Colorectal Surgery Terminated NCT00887497 Phase 4
39 Phase III Randomized Study of 5-FU, CoFactor, and Avastin vs. 5-FU, LV and Avastin for First-Line Colorectal Cancer. Unknown status NCT00337389 Phase 3
40 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) Unknown status NCT00433927 Phase 3
41 Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer Unknown status NCT00643877 Phase 3
42 Combination Chemotherapy Treatments in Patients With Colorectal Cancer Stage II and III Unknown status NCT01196260 Phase 2, Phase 3
43 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00274872 Phase 2, Phase 3
44 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3
45 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3
46 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3
47 A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer Unknown status NCT00385970 Phase 3
48 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3
49 Surgery With or Without Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer Unknown status NCT00006479 Phase 3
50 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver Unknown status NCT00002692 Phase 3

Search NIH Clinical Center for Colorectal Cancer 5

Genetic Tests for Colorectal Cancer 5

Genetic tests related to Colorectal Cancer 5:

id Genetic test Affiliating Genes
1 Colorectal Cancer 5 29

Anatomical Context for Colorectal Cancer 5

Publications for Colorectal Cancer 5

Articles related to Colorectal Cancer 5:

id Title Authors Year
1
Colorectal cancer: 5 big questions. ( 25970454 )
2015

Variations for Colorectal Cancer 5

Expression for Colorectal Cancer 5

Search GEO for disease gene expression data for Colorectal Cancer 5.

Pathways for Colorectal Cancer 5

Pathways related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 DPYD UMPS
2
Show member pathways
11.68 MSH6 SMAD3
3
Show member pathways
11.6 DPYD UMPS
4 11.37 MSH6 SMAD3
5
Show member pathways
11.09 DPYD UMPS
6 10.29 MSH6 SMAD3

GO Terms for Colorectal Cancer 5

Cellular components related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.62 MSH6 SMAD3

Molecular functions related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.13 DPYD MSH6 SMAD3
2 double-stranded DNA binding GO:0003690 8.62 MSH6 SMAD3

Sources for Colorectal Cancer 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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