MCID: CLR080
MIFTS: 19

Colorectal Cancer 5

Categories: Rare diseases, Gastrointestinal diseases, Genetic diseases, Cancer diseases

Aliases & Classifications for Colorectal Cancer 5

MalaCards integrated aliases for Colorectal Cancer 5:

Name: Colorectal Cancer 5 53 28
Colorectal Cancer, Susceptibility to, 5 53 13
Colorectal Cancer, Susceptibility to, on Chromosome 10 53
Colorectal Cancer on Chromosome 10 53
Crcs5 53

Classifications:



External Ids:

OMIM 53 612230

Summaries for Colorectal Cancer 5

MalaCards based summary : Colorectal Cancer 5, also known as colorectal cancer, susceptibility to, 5, is related to colorectal cancer and colorectal cancer, hereditary nonpolyposis, type 5. An important gene associated with Colorectal Cancer 5 is CRCS5 (Colorectal Cancer, Susceptibility To, 5), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Integrated Cancer Pathway. The drugs Capecitabine and Paclitaxel have been mentioned in the context of this disorder.

Description from OMIM: 612230

Related Diseases for Colorectal Cancer 5

Symptoms & Phenotypes for Colorectal Cancer 5

Clinical features from OMIM:

612230

Drugs & Therapeutics for Colorectal Cancer 5

Drugs for Colorectal Cancer 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
2
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
3 Albumin-Bound Paclitaxel Phase 1
4 Antimetabolites Phase 1
5 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib in Combination With Capecitabine in Patients With Metastatic Breast Cancer Completed NCT01498458 Phase 1 Pazopanib plus capecitabine

Search NIH Clinical Center for Colorectal Cancer 5

Genetic Tests for Colorectal Cancer 5

Genetic tests related to Colorectal Cancer 5:

# Genetic test Affiliating Genes
1 Colorectal Cancer 5 28

Anatomical Context for Colorectal Cancer 5

Publications for Colorectal Cancer 5

Articles related to Colorectal Cancer 5:

# Title Authors Year
1
Colorectal cancer: 5 big questions. ( 25970454 )
2015

Variations for Colorectal Cancer 5

Expression for Colorectal Cancer 5

Search GEO for disease gene expression data for Colorectal Cancer 5.

Pathways for Colorectal Cancer 5

Pathways related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 MSH6 SMAD3
2 10.29 MSH6 SMAD3

GO Terms for Colorectal Cancer 5

Cellular components related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.62 MSH6 SMAD3

Molecular functions related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.62 MSH6 SMAD3

Sources for Colorectal Cancer 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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