MCID: CLR080
MIFTS: 34

Colorectal Cancer 5

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 5

MalaCards integrated aliases for Colorectal Cancer 5:

Name: Colorectal Cancer 5 54 29
Colorectal Cancer, Susceptibility to, 5 13

Classifications:



External Ids:

OMIM 54 612230

Summaries for Colorectal Cancer 5

MalaCards based summary : Colorectal Cancer 5, also known as colorectal cancer, susceptibility to, 5, is related to colorectal cancer and colorectal cancer, hereditary nonpolyposis, type 5. An important gene associated with Colorectal Cancer 5 is CRCS5 (Colorectal Cancer, Susceptibility To, 5), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Colorectal Cancer Metastasis. The drugs Fluorouracil and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and lung.

Description from OMIM: 612230

Related Diseases for Colorectal Cancer 5

Graphical network of the top 20 diseases related to Colorectal Cancer 5:



Diseases related to Colorectal Cancer 5

Symptoms & Phenotypes for Colorectal Cancer 5

Clinical features from OMIM:

612230

Drugs & Therapeutics for Colorectal Cancer 5

Drugs for Colorectal Cancer 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 509)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
2
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
3
Tegafur Approved Phase 4,Phase 3,Phase 1,Phase 2 17902-23-7 5386
4
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
5
Capecitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 154361-50-9 60953
6
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
7
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
8
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
9
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
10
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1 205923-56-4 56842117 2333
11
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
12
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
13
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
14
Ethiodized oil Approved Phase 4 8008-53-5
15
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
16
Zinc Approved Phase 4 7440-66-6 32051 23994
17
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
18
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
20 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
21
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
22
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
23
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1 7689-03-4
24 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
26 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 calcium heparin Phase 4,Phase 3,Phase 2,Phase 1
30 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
32 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1
33 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
34 Antidotes Phase 4,Phase 3,Phase 2,Phase 1
35 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
36 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
38 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
39 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
40 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
41 Vasodilator Agents Phase 4,Phase 3,Phase 1
42 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
48 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
49 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
50 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1185)

id Name Status NCT ID Phase Drugs
1 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
2 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
3 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
4 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
5 Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants Completed NCT00138060 Phase 4 irinotecan;5 fluorouracil
6 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
7 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
8 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
9 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
10 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
11 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy
12 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4 Capecitabine
13 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
14 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
15 Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery Completed NCT01075646 Phase 4 ropivacaine;saline solution
16 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
17 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Recruiting NCT02557490 Phase 4 oxaliplatin and raltitrexed
18 Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4 Panitumumab
19 Efficacy and Safety of Raltitrexed-based Transarterial Chemoembolisation(TACE)for Colorectal Cancer Liver Metastases Recruiting NCT01959061 Phase 4 Raltitrexed;Oxaliplatin;lipiodol
20 The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib Recruiting NCT02800330 Phase 4 Esomeprazole 40mg concomitantly;Esomeprazole 40mg before;Regorafenib 160mg or 120mg
21 Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients Active, not recruiting NCT01271582 Phase 4 Irinotecan, 5FU, leucovorin
22 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Active, not recruiting NCT01315990 Phase 4 FOLFIRI + Cetuximab
23 Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia Active, not recruiting NCT02032953 Phase 4 Insulin
24 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Not yet recruiting NCT02746432 Phase 4 Hyper insulinemic euglycemic clamp
25 Study Comparing Optimized 5-FU Dosing and Standard Dosing in Metastatic Colorectal Cancer Patients Treated With mFOLFOX6 Terminated NCT01468623 Phase 4
26 A Study to Compare Two Avastin-Based Treatment Regimens for the Treatment of Metastatic Colorectal Cancer Terminated NCT00114946 Phase 4 Avastin
27 Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)
28 A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting Terminated NCT00418678 Phase 4 Cesamet
29 Ischemic Conditioning (Delay Phenomenon) in Colorectal Surgery Terminated NCT00887497 Phase 4
30 Phase III Randomized Study of 5-FU, CoFactor, and Avastin vs. 5-FU, LV and Avastin for First-Line Colorectal Cancer. Unknown status NCT00337389 Phase 3 5- Fluorouracil (5-FU);bevacizumab (Avastin);Leucovorin;CoFactor (ANX-510)
31 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) Unknown status NCT00433927 Phase 3 5-FU;folinic acid;irinotecan;cetuximab;bevacizumab
32 Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer Unknown status NCT00643877 Phase 3
33 Combination Chemotherapy Treatments in Patients With Colorectal Cancer Stage II and III Unknown status NCT01196260 Phase 2, Phase 3 Capecitabine and Oxaliplatin
34 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00274872 Phase 2, Phase 3 fluorouracil;leucovorin calcium;oxaliplatin
35 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;semaxanib
36 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
37 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
38 A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer Unknown status NCT00385970 Phase 3 Tegafur-uracil (UFT);Calcium folinate (LV);Krestin (PSK)
39 Surgery With or Without Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer Unknown status NCT00006479 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
40 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver Unknown status NCT00002692 Phase 3 fluorouracil;isolated perfusion;leucovorin calcium
41 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
42 Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines Unknown status NCT01547923 Phase 3
43 Randomized Phase III Adjuvant Study for Stage III Colorectal Cancer Unknown status NCT00209742 Phase 3 UFT;USEL/Leucovorin;Krestin
44 Trial of FOLF(HA)Iri Versus FOLFIRI in mCRC Unknown status NCT01290783 Phase 3 Irintoecan;HA-Irinotecan solution for Infusion
45 Compare FOFLOX4 in Preoperative and Postoperative and Postoperative in Resectable Liver Metastasis Colorectal Cancer (MCC) Unknown status NCT01035385 Phase 3 FOFLOX4
46 Comparison of Laparoscopic Colectomy Versus Open Colectomy for Colorectal Cancer: … A Prospective Randomized Trial Unknown status NCT00155727 Phase 3
47 Combination Chemotherapy in Treating Patients With Colon Cancer Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
48 The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal Cancer Unknown status NCT01426490 Phase 2, Phase 3
49 FOLFIRI or mFOLFOX6 in Adjuvant Chemotherapy in Advanced Colorectal Cancer Unknown status NCT01566942 Phase 3 Oxaliplatin;Irinotecan
50 Preoperative Radiotherapy and Local Excision in Rectal Cancer Unknown status NCT00738790 Phase 3

Search NIH Clinical Center for Colorectal Cancer 5

Genetic Tests for Colorectal Cancer 5

Genetic tests related to Colorectal Cancer 5:

id Genetic test Affiliating Genes
1 Colorectal Cancer 5 29

Anatomical Context for Colorectal Cancer 5

MalaCards organs/tissues related to Colorectal Cancer 5:

39
Liver, Colon, Lung, Testes, Endothelial, T Cells, Prostate

Publications for Colorectal Cancer 5

Articles related to Colorectal Cancer 5:

id Title Authors Year
1
Colorectal cancer: 5 big questions. ( 25970454 )
2015

Variations for Colorectal Cancer 5

Expression for Colorectal Cancer 5

Search GEO for disease gene expression data for Colorectal Cancer 5.

Pathways for Colorectal Cancer 5

GO Terms for Colorectal Cancer 5

Cellular components related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.62 MSH6 SMAD3

Molecular functions related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.13 DPYD MSH6 SMAD3
2 double-stranded DNA binding GO:0003690 8.62 MSH6 SMAD3

Sources for Colorectal Cancer 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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