MCID: CLR081
MIFTS: 31

Colorectal Cancer 6

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 6

MalaCards integrated aliases for Colorectal Cancer 6:

Name: Colorectal Cancer 6 54
Colorectal Cancer, Susceptibility to, 6 13

Classifications:



External Ids:

OMIM 54 612231

Summaries for Colorectal Cancer 6

MalaCards based summary : Colorectal Cancer 6, also known as colorectal cancer, susceptibility to, 6, is related to colorectal cancer, hereditary nonpolyposis, type 6 and nail disorder, nonsyndromic congenital, 3,. An important gene associated with Colorectal Cancer 6 is CRCS6 (Colorectal Cancer, Susceptibility To, 6), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. The drugs Cetuximab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and lung.

Description from OMIM: 612231

Related Diseases for Colorectal Cancer 6

Symptoms & Phenotypes for Colorectal Cancer 6

Clinical features from OMIM:

612231

Drugs & Therapeutics for Colorectal Cancer 6

Drugs for Colorectal Cancer 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 438)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1 205923-56-4 56842117 2333
2
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
3
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
4
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
5
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
6
Tegafur Approved Phase 4,Phase 3,Phase 2 17902-23-7 5386
7
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
8
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
9
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
10
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
11
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
12
Zinc Approved Phase 4 7440-66-6 32051 23994
13
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
16 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
17 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
18 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
19 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Erythromycin Estolate Phase 4
23 Erythromycin Ethylsuccinate Phase 4
24 Erythromycin stearate Phase 4
25 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
27 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
28 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
29 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
30 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1
31 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
32 Antidotes Phase 4,Phase 3,Phase 2,Phase 1
33 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
34 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
36 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1
37 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
38 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
39 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
40 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
42 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
43 Hormones Phase 4,Phase 3,Phase 2,Phase 1
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
45 Hypoglycemic Agents Phase 4,Phase 2
46 insulin Phase 4,Phase 2
47 Insulin, Globin Zinc Phase 4,Phase 2
48 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
49 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 823)

id Name Status NCT ID Phase Drugs
1 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
2 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
3 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
4 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
5 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
6 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
7 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4 Capecitabine
8 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
9 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
10 Nutrition for Colorectal Cancer Patients and Neutrophil Functions Completed NCT01831310 Phase 4
11 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
12 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
13 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4 Capecitabine
14 Medium Calorie Parenteral Nutrition on Patients With Gastrointestinal Cancer Undergoing Surgery Completed NCT01700062 Phase 4
15 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
16 STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea Completed NCT00050635 Phase 4 Sandostatin LAR Depot
17 Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4 Panitumumab
18 Resection vs no Resection of the Primary in Colorectal Cancer With Unresectable Metastases Recruiting NCT02015923 Phase 4 Chemotherapy- scheme
19 Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia Active, not recruiting NCT02032953 Phase 4 Insulin
20 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Not yet recruiting NCT02354560 Phase 4 Erythromycin
21 Study Comparing Optimized 5-FU Dosing and Standard Dosing in Metastatic Colorectal Cancer Patients Treated With mFOLFOX6 Terminated NCT01468623 Phase 4
22 Elaboration of a Model for Predicting Efficacy of Monoclonal Antibodies (Cetuximab and Bevacizumab) in Patients With Colorectal Cancer and Liver Metastases Terminated NCT00327093 Phase 4 cetuximab;bevacizumab
23 Assessment and Tracking of Long-term Alefacept Safety Terminated NCT00454701 Phase 4 Alefacept exposure
24 A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting Terminated NCT00418678 Phase 4 Cesamet
25 FOLFIRI or mFOLFOX6 in Adjuvant Chemotherapy in Advanced Colorectal Cancer Unknown status NCT01566942 Phase 3 Oxaliplatin;Irinotecan
26 The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal Cancer Unknown status NCT01426490 Phase 2, Phase 3
27 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer Unknown status NCT00003260 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
28 Increasing Colorectal Cancer Screening in African Americans Unknown status NCT00893295 Phase 3
29 Personalized Screening Plans to Increase Colorectal Cancer Screening in Healthy Participants Unknown status NCT00617071 Phase 3
30 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
31 Pre-emptive Cycline Treatment on Cetuximab Induced Skin Toxicity in Colorectal Cancer Unknown status NCT01317433 Phase 3 Doxycycline;Cetuximab
32 Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine for Advanced Colorectal Cancer or Breast Cancer Unknown status NCT00559858 Phase 3
33 Comparison of Laparoscopic Colectomy Versus Open Colectomy for Colorectal Cancer: … A Prospective Randomized Trial Unknown status NCT00155727 Phase 3
34 Maintenance Treatment Versus Observation After Induction in Advanced Colorectal Carcinoma Unknown status NCT00442637 Phase 3 capecitabine + bevacizumab
35 Combination Chemotherapy After Surgery in Treating Patients With High-Risk Stage II or Stage III Colorectal Cancer Unknown status NCT00749450 Phase 3 capecitabine;fluorouracil;oxaliplatin
36 Acetylsalicylic Acid and Colorectal Cancer Prevention: Exploring the Platelet Function of Its Mechanism of Action Unknown status NCT02125409 Phase 3 Acetylsalicylic acid
37 Bevacizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00797485 Phase 3 capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium
38 The Efficacy of the Caregiver Psychoeducational Consultation Program Unknown status NCT01001884 Phase 2, Phase 3
39 The Role of Glutamine for Preventing Oxaliplatin-Induced Peripheral Neuropathy Unknown status NCT02024191 Phase 3
40 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
41 Effect of Enteral Nutrition Rich in Eicosapentaenoic Acid (EPA) on Patients Receiving Chemotherapy for GI Tumor Unknown status NCT01048463 Phase 3 Nutriall;LDEPA;Placebo;HDEPA;Chemotherapy
42 Preoperative Radiotherapy and Local Excision in Rectal Cancer Unknown status NCT00738790 Phase 3
43 Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer Unknown status NCT00295035 Phase 3 CELECOXIB;CURCUMIN
44 Tamoxifen Versus Anastrozole, Alone or in Combination With Zoledronic Acid Unknown status NCT00295646 Phase 3 tamoxifen;anastrozole;zoledronic acid
45 Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer Completed NCT00766155 Phase 3 capecitabine;oxaliplatin
46 A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-CC) Completed NCT00152230 Phase 3 UFT (uracil, tegafur)
47 Low-Literacy Physician-Patient Intervention Promoting Colorectal Cancer Screening Completed NCT01103479 Phase 2, Phase 3
48 Promoting Physical Activity After Colorectal Cancer Completed NCT00230646 Phase 3
49 Study of Bevacizumab Alone or Combined With Capecitabine and Oxaliplatin as Support Therapy in Metastatic Colorectal Cancer Patients Completed NCT00335595 Phase 3 XELOXA;XELOXA-A
50 A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Chinese Patients With Metastatic Colorectal Cancer. Completed NCT00642577 Phase 3 bevacizumab [Avastin];irinotecan;leucovorin;fluorouracil

Search NIH Clinical Center for Colorectal Cancer 6

Genetic Tests for Colorectal Cancer 6

Anatomical Context for Colorectal Cancer 6

MalaCards organs/tissues related to Colorectal Cancer 6:

39
Liver, Colon, Lung, Testes, Prostate, T Cells, Skin

Publications for Colorectal Cancer 6

Variations for Colorectal Cancer 6

Expression for Colorectal Cancer 6

Search GEO for disease gene expression data for Colorectal Cancer 6.

Pathways for Colorectal Cancer 6

GO Terms for Colorectal Cancer 6

Biological processes related to Colorectal Cancer 6 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.37 CDKN1B TGFBR2
2 regulation of cell proliferation GO:0042127 9.32 CDKN1B TGFBR2
3 response to hypoxia GO:0001666 9.26 CDKN1B TGFBR2
4 response to organic cyclic compound GO:0014070 9.16 CDKN1B TGFBR2
5 Notch signaling pathway GO:0007219 8.96 CDKN1B TGFBR2
6 response to glucose GO:0009749 8.62 CDKN1B TGFBR2

Sources for Colorectal Cancer 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....