MCID: CLR083
MIFTS: 26

Colorectal Cancer 8

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 8

MalaCards integrated aliases for Colorectal Cancer 8:

Name: Colorectal Cancer 8 54 29
Colorectal Cancer, Susceptibility to, 8 13

Classifications:



External Ids:

OMIM 54 612589

Summaries for Colorectal Cancer 8

MalaCards based summary : Colorectal Cancer 8, also known as colorectal cancer, susceptibility to, 8, is related to colorectal cancer, hereditary nonpolyposis, type 8 and townes-brocks syndrome 2. An important gene associated with Colorectal Cancer 8 is CRCS8 (Colorectal Cancer, Susceptibility To, 8). The drugs Iron and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung.

Description from OMIM: 612589

Related Diseases for Colorectal Cancer 8

Symptoms & Phenotypes for Colorectal Cancer 8

Clinical features from OMIM:

612589

Drugs & Therapeutics for Colorectal Cancer 8

Drugs for Colorectal Cancer 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 381)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
4
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
5
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
6
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
7
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
8
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
9
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
10
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
12
Menadione Approved, Nutraceutical Phase 4,Phase 2 58-27-5 4055
13
Phytonadione Approved, Nutraceutical Phase 4,Phase 2 84-80-0 4812 5284607
14 tannic acid Approved, Nutraceutical Phase 4
15 Ferrous fumarate Phase 4
16 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
17 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
18 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
19 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
20 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
21 calcium heparin Phase 4,Phase 3,Phase 2
22 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
23 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
25 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1
26 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
27 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antibodies, Monoclonal Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
29 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
31 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
32 Vitamin K 1 Phase 4,Phase 2
33 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
34 Mitogens Phase 4,Phase 3,Phase 2,Phase 1
35 alanine Nutraceutical Phase 4,Phase 2
36 Cola Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
37 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
38 Menaquinone Nutraceutical Phase 4,Phase 2
39 naphthoquinone Nutraceutical Phase 4,Phase 2
40 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
41 Vitamin K Nutraceutical Phase 4,Phase 2
42 glutamine Nutraceutical Phase 4
43 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 1,Phase 2
44
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741 24759
45
Levoleucovorin Approved Phase 3,Phase 2,Phase 1 68538-85-2
46
Floxuridine Approved Phase 3,Phase 2 50-91-9 5790
47
Dalteparin Approved Phase 3 9005-49-6
48
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
49
Celecoxib Approved, Investigational Phase 3,Phase 2,Phase 1 169590-42-5 2662
50
Trifluridine Approved Phase 3,Phase 2,Phase 1 70-00-8 6256

Interventional clinical trials:

(show top 50) (show all 512)

id Name Status NCT ID Phase Drugs
1 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4 Ferrous fumarate;ferric(III)carboxymaltose
2 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy
3 Nutrition for Colorectal Cancer Patients and Neutrophil Functions Completed NCT01831310 Phase 4
4 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
5 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
6 Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients Completed NCT01641458 Phase 4
7 Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum Completed NCT01175317 Phase 4
8 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed NCT01588990 Phase 4 Oxaliplatin;Capecitabine;Bevacizumab;Leucovorin;5-Fluouracil;Irinotecan
9 Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4 Panitumumab
10 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Active, not recruiting NCT01315990 Phase 4 FOLFIRI + Cetuximab
11 FOLFIRI or mFOLFOX6 in Adjuvant Chemotherapy in Advanced Colorectal Cancer Unknown status NCT01566942 Phase 3 Oxaliplatin;Irinotecan
12 Trial of FOLF(HA)Iri Versus FOLFIRI in mCRC Unknown status NCT01290783 Phase 3 Irintoecan;HA-Irinotecan solution for Infusion
13 Comparison of Laparoscopic Colectomy Versus Open Colectomy for Colorectal Cancer: … A Prospective Randomized Trial Unknown status NCT00155727 Phase 3
14 Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer Unknown status NCT00643877 Phase 3
15 ONE WEEK VERSUS FOUR WEEK HEPARIN PROPHYLAXIS AFTER LAPAROSCOPIC SURGERY FOR COLORECTAL CANCER. Unknown status NCT01589146 Phase 3 Heparin, Low-Molecular-Weight
16 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
17 Preoperative Radiotherapy and Local Excision in Rectal Cancer Unknown status NCT00738790 Phase 3
18 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
19 Transrectal Vacuum Assisted Drainage: A New Method of Treating Anastomotic Leakage After Rectal Resection Unknown status NCT00773981 Phase 3
20 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) Unknown status NCT00433927 Phase 3 5-FU;folinic acid;irinotecan;cetuximab;bevacizumab
21 Biological Therapy With Combination Chemotherapy in Patients With Colorectal Cancer Unknown status NCT00003063 Phase 3 fluorouracil;leucovorin calcium;levamisole hydrochloride
22 The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer Unknown status NCT00833131 Phase 3
23 Trial Of Irinotecan In Combination With Three Methods Of Administration Of Fluoropyrimidine. Completed NCT00101686 Phase 3 Modified Bolus 5-FU/LV with Irinotecan;FOLFIRI + bevacizumab;miFL + bevacizumab;Infusional 5-FU/LV with Irinotecan;Oral Capecitabine with Irinotecan
24 XENOX – Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Chemotherapy Completed NCT00272051 Phase 3 SR57746A
25 Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRYSTAL) Completed NCT00154102 Phase 3 Cetuximab;FOLFIRI (5-Fluorouracil, Folinic acid, Irinotecan)
26 Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies Completed NCT01607957 Phase 3 TAS-102;Placebo
27 Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy With 5-Fluorouracil and Oxaliplatin Versus 5-Fluorouracil Alone in Rectal Cancer Completed NCT00349076 Phase 3 5-FU and oxaliplatin;5-FU
28 Aspirin/Folate Prevention of Large Bowel Polyps Completed NCT00272324 Phase 2, Phase 3 Aspirin;Folate
29 Combination Chemotherapy in Treating Patients With Colorectal Cancer Completed NCT00006103 Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium
30 Cetuximab, Capecitabine, Oxaliplatin and Bevacizumab in Advanced Colorectal Cancer Completed NCT00208546 Phase 3 21Capecitabine + bevacizumab + oxaliplatin;1Capecitabine + oxaliplatin + bevacizumab + cetuximab
31 Study of Cetuximab, Oxaliplatin, 5-FU/LV Versus Oxaliplatin, 5-FU/LV in Patients With Previously Treated Metastatic, EGFR-Positive Colorectal Cancer Completed NCT00061815 Phase 3 oxaliplatin;leucovorin;5-fluorouracil;5-fluorouracil
32 A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer Completed NCT00069121 Phase 3 capecitabine [Xeloda];Oxaliplatin;Oxaliplatin;Leucovorin;5 FU
33 Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer Completed NCT00766155 Phase 3 capecitabine;oxaliplatin
34 ABCSG 8 - Adjuvant Treatment in Patients With Hormone Receptor-positive Breast Cancer With Good to Moderate Differentiation. Completed NCT00291759 Phase 3 Tamoxifen;Anastrozole
35 A Study of Xeloda (Capecitabine) in Patients With Metastatic Colorectal Cancer Completed NCT00069108 Phase 3 5 FU;Leucovorin;Oxaliplatin;Oxaliplatin;capecitabine [Xeloda]
36 FLOX in Combination With Cetuximab in First-line Treatment of Colorectal Cancer Completed NCT00145314 Phase 3 FLOX (5-fluorouracil/folinic acid/oxaliplatin);FLOX (5-fluorouracil/folinic acid/oxaliplatin) and Cetuximab;FLOX (5-fluorouracil and folinic acid and oxaliplatin) intermittently and maintenance cetuximab
37 S9415 Chemotherapy in Patients With Stage II or III Colon Cancer That Has Been Surgically Removed Completed NCT00002593 Phase 3 fluorouracil;leucovorin calcium;levamisole hydrochloride
38 Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer Completed NCT00296608 Phase 3 fluorouracil;leucovorin calcium
39 The Safety and Efficacy of Methylene Blue MMX® Modified Release Tablets Administered to Subjects Undergoing Screening or Surveillance Colonoscopy Completed NCT01694966 Phase 3 Methylene Blue MMX®;Placebo
40 Combination Chemotherapy With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for High Risk Stage II or Stage III Colon Cancer Completed NCT00112918 Phase 3 Capecitabine;5-Fluorouracil (5-FU);Leucovorin calcium;Oxaliplatin
41 Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery Completed NCT00265811 Phase 3 Folfox + Cetuximab;Folfox
42 A Study of Xeloda (Capecitabine) Compared With 5-Fluorouracil in Combination With Low-Dose Leucovorin in Patients Who Have Undergone Surgery for Colon Cancer Completed NCT00009737 Phase 3 5-Fluorouracil;Leucovorin;Capecitabine [Xeloda]
43 Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery Completed NCT00660894 Phase 3 folinate calcium;tegafur-uracil;tegafur-gimeracil-oteracil potassium
44 A Trial Comparing Adjuvant Oral UFT/LV to 5-FU/l-LV in Stage III Colorectal Cancer (JCOG-0205-MF) Completed NCT00190515 Phase 3 5FU+l-leucovorin;UFT+Leucovorin
45 Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral Nasal Polyposis Followed by an 8-Week Open-Label Exten Completed NCT01622569 Phase 3 rescue med
46 A Study in Second Line Metastatic Colorectal Cancer Completed NCT01183780 Phase 3 Irinotecan;Folinic Acid;5-Fluorouracil
47 SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed Completed NCT00002551 Phase 3 fluorouracil;leucovorin calcium;levamisole hydrochloride
48 Cetuximab, Bevacizumab & 5FU/Leucovorin vs. Oxaliplatin, Bevacizumab & 5FU/Leucovorin in Metastatic Colorectal Cancer Completed NCT00252564 Phase 3 Bevacizumab;Oxaliplatin;Leucovorin;Fluorouracil;Cetuximab
49 Nintedanib (BIBF 1120) vs Placebo in Refractory Metastatic Colorectal Cancer (LUME-Colon 1) Completed NCT02149108 Phase 3 Nintedanib (BIBF 1120);Placebo;BSC;BSC
50 Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET Completed NCT00583323 Phase 3 Lomotil

Search NIH Clinical Center for Colorectal Cancer 8

Genetic Tests for Colorectal Cancer 8

Genetic tests related to Colorectal Cancer 8:

id Genetic test Affiliating Genes
1 Colorectal Cancer 8 29

Anatomical Context for Colorectal Cancer 8

MalaCards organs/tissues related to Colorectal Cancer 8:

39
Colon, Liver, Lung, Testes, Skin, T Cells, Prostate

Publications for Colorectal Cancer 8

Variations for Colorectal Cancer 8

Expression for Colorectal Cancer 8

Search GEO for disease gene expression data for Colorectal Cancer 8.

Pathways for Colorectal Cancer 8

GO Terms for Colorectal Cancer 8

Sources for Colorectal Cancer 8

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