MCID: CLR034
MIFTS: 41

Colorectal Cancer, Somatic malady

Cancer category

Summaries for Colorectal Cancer, Somatic

Sources:
47OMIM, 33MalaCards
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MalaCards: Colorectal Cancer, Somatic is related to colorectal cancer and gastric cancer, somatic. An important gene associated with Colorectal Cancer, Somatic is MLH3 (mutL homolog 3), and among its related pathways are Regulation of Microtubule Cytoskeleton and Estrogen signaling pathway. The compounds resveratrol and fpa 124 have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and prostate, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Description from OMIM:47 114500

Aliases & Classifications for Colorectal Cancer, Somatic

Sources:
47OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

colorectal cancer, somatic 47


Related Diseases for Colorectal Cancer, Somatic

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Colorectal Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer30.9FGFR3, APC, PIK3CA, EP300, BRAF, CTNNB1
2gastric cancer, somatic30.4PIK3CA, APC
3breast cancer, somatic30.2PIK3CA, AKT1, IGH
4prostate cancer, somatic10.2
5lung cancer, somatic10.2
6bladder carcinoma10.0FGFR3
7pituitary tumors10.0APC
8birt-hogg-dube syndrome10.0FLCN
9macroglobulinemia, waldenstrom, somatic10.0IGH
10neuroblastoma10.0AKT1
11spitz nevus10.0BRAF
12pancreatitis10.0NRAS
13juvenile polyposis syndrome10.0APC
14multiple myeloma10.0AKT1, FGFR3
15glioblastoma multiforme10.0PIK3CA, AKT1
16seborrheic keratosis10.0PIK3CA, FGFR3
17intestinal neoplasm10.0APC
18astrocytoma10.0AKT1, PIK3CA
19acute leukemia10.0PIK3CA, IGH
20rhabdomyosarcoma10.0AKT1
21gallbladder cancer10.0APC, NRAS
22ovarian cancer, somatic10.0PIK3CA, AKT1, IGH
23myeloma10.0FGFR3, IGH, AKT1
24schizophrenia10.0IGH, AKT1
25skin benign neoplasm10.0BRAF, FLCN, FGFR3
26kidney rhabdoid cancer10.0PIK3CA, BRAF, FLCN
27noonan syndrome10.0BRAF, NRAS
28myelodysplastic syndromes10.0EP300, NRAS
29thyroid adenoma10.0PIK3CA, APC, BRAF
30lung cancer10.0NRAS, PIK3CA, AKT1
31nephroblastoma10.0CTNNB1
32short stature10.0BRAF, FGFR3, EP300
33cholangiocarcinoma10.0PIK3CA, NRAS, BRAF
34osteosarcoma10.0EP300
35thyroid cancer10.0BRAF, PIK3CA, FGFR3, APC
36gardner syndrome10.0APC, CTNNB1
37cervical cancer10.0FGFR3, EP300, PIK3CA, BRAF
38sarcoma10.0NRAS, BRAF, EP300
39hepatocellular adenoma10.0APC, CTNNB1
40lynch syndrome10.0MLH3, APC, BRAF, NRAS
41thyroid cancer, anaplastic10.0PIK3CA, BRAF, CTNNB1
42hypertrophy of breast10.0AKT1, PIK3CA, FGFR3, APC, EP300
43retinoblastoma10.0PIK3CA, AKT1, EP300, FGFR3, APC
44hepatoblastoma10.0APC, CTNNB1, AXIN2
45turcot syndrome10.0CTNNB1, APC
46papillary thyroid carcinoma10.0CTNNB1, BRAF, APC
47kidney cancer10.0FLCN, PIK3CA, AKT1, BRAF
48gastric adenocarcinoma10.0APC, CTNNB1, PIK3CA
49burkitt's lymphoma10.0AKT1, IGH, EP300, FGFR3, PIK3CA
50hepatocellular carcinoma10.0PIK3CA, DLC1, APC, CTNNB1, AKT1

Graphical network of the top 20 diseases related to Colorectal Cancer, Somatic:



Diseases related to colorectal cancer, somatic

Clinical Features for Colorectal Cancer, Somatic

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114500

Drugs & Therapeutics for Colorectal Cancer, Somatic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Colorectal Cancer, Somatic

Drug clinical trials:

Search ClinicalTrials for Colorectal Cancer, Somatic

Search NIH Clinical Center for Colorectal Cancer, Somatic

Search CenterWatch for Colorectal Cancer, Somatic

Genetic Tests for Colorectal Cancer, Somatic

Anatomical Context for Colorectal Cancer, Somatic

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Colorectal Cancer, Somatic:

33
Lung, Breast, Prostate

Animal Models for Colorectal Cancer, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Colorectal Cancer, Somatic:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.1AXIN2
2MP:00053679.7APC, FLCN, FGFR3
3MP:00053759.7BUB1B, APC
4MP:00053799.5PIK3CA, AKT1, MLH3, AXIN2
5MP:00053699.3EP300, BUB1B, APC, BRAF
6MP:00036319.2APC, DCC, AXIN2, DLC1
7MP:00053809.2APC, FLCN, BUB1B, AXIN2, DLC1
8MP:00053919.0APC, DCC, BUB1B, AXIN2, FGFR3
9MP:00053909.0FGFR3, AXIN2, BUB1B, AKT1, APC
10MP:00107718.8APC, CTNNB1, PIK3CA, AKT1, NRAS
11MP:00053888.7FGFR3, EP300, AKT1, CTNNB1
12MP:00053898.6BRAF, APC, CTNNB1, PIK3CA, AKT1, MLH3
13MP:00053768.6PIK3CA, FLCN, AKT1, NRAS, BUB1B, EP300
14MP:00053828.2BRAF, APC, CTNNB1, AXIN2, EP300, FGFR3
15MP:00053817.9BRAF, APC, CTNNB1, DCC, NRAS, EP300
16MP:00028737.8BRAF, APC, CTNNB1, AKT1, NRAS, AXIN2
17MP:00053877.3BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1
18MP:00053977.3BRAF, APC, CTNNB1, FLCN, AKT1, NRAS
19MP:00053787.0PIK3CA, CTNNB1, APC, BRAF, FLCN, AKT1
20MP:00053856.9BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1
21MP:00020066.9FGFR3, BRAF, APC, CTNNB1, PIK3CA, FLCN
22MP:00053846.5FLCN, PIK3CA, CTNNB1, APC, BRAF, AKT1
23MP:00107686.2FLCN, PIK3CA, CTNNB1, APC, BRAF, AKT1

Publications for Colorectal Cancer, Somatic

Sources:
51PubMed
See all sources

Articles related to Colorectal Cancer, Somatic:

(show all 47)
idTitleAuthorsYear
1
Germline and somatic polymerase I/ and I' mutations define a new class of hypermutated colorectal and endometrial cancers. (23447401)
2013
2
Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. (23505554)
2013
3
Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women. (22337533)
2012
4
A meta-analysis of the prevalence of somatic mutations in the hMLH1 and hMSH2 genes in colorectal cancer. (21988782)
2012
5
Somatic mutation of a tumor suppressor gene BAP1 is rare in breast, prostate, gastric and colorectal cancers. (22958294)
2012
6
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. (23132392)
2012
7
Somatic mutations of caspase-2 gene in gastric and colorectal cancers. (21940110)
2011
8
BRAF p.Val600Glu (V600E) somatic mutation is mainly associated with MSS phenotype in metastatic colorectal cancer. (21289333)
2011
9
Somatic mutations and germline sequence variants in patients with familial colorectal cancer. (21351276)
2010
10
Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability. (20955454)
2010
11
Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. (20388775)
2010
12
Somatic mutation of EXO1 gene in gastric and colorectal cancers with microsatellite instability. (20429728)
2010
13
Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer. (20200438)
2010
14
Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. (20198652)
2010
15
Prognostic significance of interaction between somatic APC mutations and 5-fluorouracil adjuvant chemotherapy in Taiwanese colorectal cancer subjects. (19307944)
2009
16
Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary. (18369740)
2008
17
Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. (18628431)
2008
18
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. (18541649)
2008
19
Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD). (18186519)
2008
20
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. (18804418)
2008
21
May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers? (17653897)
2007
22
MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. (17621591)
2007
23
Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer. (18022921)
2007
24
Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer. (17453358)
2007
25
Novel germline and somatic mutations of the MSH2 gene in hereditary non-polyposis colorectal cancer. (17250671)
2007
26
Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years. (16765042)
2006
27
Somatic BRAF-V600E mutations in familial colorectal cancer. (17119056)
2006
28
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families. (15788729)
2005
29
Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer. (14670621)
2004
30
Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. (15350299)
2004
31
Somatic mutations of APC gene in carcinomas from hereditary non-polyposis colorectal cancer patients. (15040027)
2004
32
Novel germline hMSH2 genomic deletion and somatic hMSH2 mutations in a hereditary nonpolyposis colorectal cancer family. (15063132)
2004
33
Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. (12707038)
2003
34
hMLH1 and hMSH2 somatic inactivation mechanisms in sporadic colorectal cancer patients. (14688830)
2003
35
Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers. (12386821)
2002
36
Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation. (11807791)
2002
37
Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: evidence for somatic mutation in colorectal cancers. (11317354)
2001
38
Somatic alterations of the DPC4 and Madr2 genes in colorectal cancers and relationship to metastasis. (11172591)
2001
39
Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer. (10934138)
2000
40
Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers. (9823979)
1998
41
Somatic alterations of the SMAD-2 gene in human colorectal cancers. (9820171)
1998
42
Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. (9500462)
1998
43
Somatic mutations, acetylator status, and prognosis in colorectal cancer. (9659162)
1998
44
Hereditary nonpolyposis colorectal cancer: causative role of a germline missense mutation in the hMLH1 gene confirmed by the independent occurrence of the same somatic mutation in tumour tissue. (9272156)
1997
45
Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers. (9240418)
1997
46
Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. (8898652)
1996
47
Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations. (8613431)
1996

Genetic Variations for Colorectal Cancer, Somatic

Expression for genes affiliated with Colorectal Cancer, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Colorectal Cancer, Somatic

Search GEO for disease gene expression data for Colorectal Cancer, Somatic.

Pathways for genes affiliated with Colorectal Cancer, Somatic

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN, 30KEGG, 50PharmGKB, 60Tocris Bioscience, 53R&D Systems
See all sources

Pathways related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7APC, PIK3CA, AKT1
29.7BRAF, PIK3CA, AKT1
3
G-protein signaling Cross-talk between Ras-family GTPases
Hide members
9.7PIK3CA, BRAF, AKT1
4
Hide members
9.5PIK3CA, FGFR3, NRAS
5
Hide members
9.5FGFR3, NRAS, BRAF
6
Hide members
9.5FGFR3, NRAS, BRAF
79.3PIK3CA, CTNNB1, AKT1
8
Hide members
9.3AKT1, APC, CTNNB1
9
Development FGF-family signaling
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9.3FGFR3, AKT1, PIK3CA, NRAS
10
Hide members
9.2NRAS, AKT1, BRAF, PIK3CA
11
Hide members
9.2PIK3CA, AKT1, NRAS, BRAF
129.2AKT1, NRAS, PIK3CA, BRAF
13
Hide members
9.2BRAF, NRAS, AKT1, PIK3CA
149.2AXIN2, APC, CTNNB1
15
Development Prolactin receptor signaling
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9.2EP300, NRAS, AKT1, PIK3CA
169.1NRAS, CTNNB1, BRAF
17
Hide members
9.0CTNNB1, PIK3CA, AKT1, BRAF
18
Development A2B receptor- action via G-protein alpha s
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9.0BRAF, CTNNB1, AKT1, PIK3CA
19
Hide members
9.0APC, CTNNB1, PIK3CA, BRAF
20
Transcription Androgen Receptor nuclear signaling
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9.0EP300, CTNNB1, PIK3CA, AKT1
21
Hide members
9.0BRAF, AKT1, FGFR3, NRAS, PIK3CA
228.9EP300, BRAF, AKT1, CTNNB1
23
Hide members
8.9NRAS, FGFR3, APC, BRAF, PIK3CA
248.9FGFR3, PIK3CA, APC, EP300, NRAS
25
Hide members
8.9EP300, NRAS, AKT1, BRAF, FGFR3
26
Hide members
8.9NRAS, FGFR3, EP300, BRAF, AKT1
278.9AXIN2, CTNNB1, APC, EP300
288.8NRAS, AKT1, APC, CTNNB1
29
Hide members
8.8CTNNB1, AKT1, BRAF, NRAS
30
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8.7BRAF, IGH, NRAS, AKT1, PIK3CA
31
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8.6NRAS, CTNNB1, PIK3CA, AKT1, FGFR3
32
Hide members
8.6AXIN2, AKT1, EP300, CTNNB1, APC
33
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8.6AXIN2, AKT1, CTNNB1, EP300, APC
34
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8.6NRAS, BRAF, CTNNB1, PIK3CA, AKT1
35
Hide members
8.6PIK3CA, NRAS, AKT1, CTNNB1, BRAF
368.6BRAF, CTNNB1, AKT1, PIK3CA, NRAS
378.5APC, BRAF, NRAS, AKT1, CTNNB1
38
Hide members
8.4APC, CTNNB1, NRAS, AXIN2, EP300
39
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8.4BUB1B, DCC, AKT1, APC, CTNNB1
40
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8.3FGFR3, BRAF, APC, CTNNB1, AKT1, NRAS
41
Hide members
8.3DCC, NRAS, EP300, AKT1, CTNNB1
428.1CTNNB1, AXIN2, DCC, AKT1, BRAF, APC
43
Hide members
8.1FGFR3, NRAS, DCC, AKT1, CTNNB1, BRAF
44
Hide members
8.0BRAF, CTNNB1, AKT1, NRAS, EP300, FGFR3
457.8AKT1, PIK3CA, EP300, CTNNB1, APC, NRAS
467.8PIK3CA, DCC, EP300, AKT1, BUB1B, CTNNB1
47
Hide members
7.7EP300, NRAS, AKT1, PIK3CA, CTNNB1, FLCN
48
Hide members
7.4AXIN2, NRAS, PIK3CA, BRAF, APC, CTNNB1
49
Hide members
7.4BRAF, DLC1, APC, FGFR3, EP300, AKT1
506.8EP300, AKT1, BRAF, APC, CTNNB1, PIK3CA

Compounds for genes affiliated with Colorectal Cancer, Somatic

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1resveratrol45 60 11 2413.1EP300
2fpa 1246010.0AKT1, IGH
310-debc hydrochloride6010.0AKT1, IGH
4api-16010.0AKT1, IGH
5api-26010.0AKT1, IGH
6sc 796010.0AKT1, IGH
7methylazoxymethanol acetate4510.0APC, CTNNB1
81-hydroxyanthraquinone4510.0APC, CTNNB1
9thymine45 2410.9EP300, APC, BRAF
10pidotimod459.9CTNNB1, AXIN2
111,2-dimethylhydrazine459.9CTNNB1, APC
12azoxymethane459.8APC, CTNNB1
13samp459.6AXIN2, CTNNB1, APC
14adp45 29 2411.6APC, AKT1, BUB1B, FGFR3
15celecoxib45 60 29 50 11 2414.5APC, CTNNB1, AKT1
16ag 1478459.5AKT1, PIK3CA, CTNNB1
172-amino-3-methylimidazo(4,5-f)quinoline459.5CTNNB1, APC
18crcs459.5BRAF, APC, CTNNB1, PIK3CA
19gefitinib45 50 1111.4AKT1, PIK3CA, CTNNB1
20imatinib45 50 1111.4BRAF, CTNNB1, PIK3CA, FGFR3
21guanine45 11 2411.4APC, CTNNB1, AKT1, FGFR3
22nocodazole45 1110.3BUB1B, AKT1, CTNNB1, APC
23curcumin459.3APC, CTNNB1, AKT1, EP300
24matrigel459.3BRAF, CTNNB1, PIK3CA, AKT1
25exisulind459.3CTNNB1, APC
26sb 20358045 6010.2EP300, AKT1, CTNNB1, BRAF
27paraffin459.2BRAF, APC, CTNNB1, AKT1, FGFR3
28phosphoinositide459.1BRAF, APC, CTNNB1, PIK3CA, AKT1
29tamoxifen45 50 29 1112.1CTNNB1, PIK3CA, AKT1, EP300
30gtp45 2910.1BRAF, APC, CTNNB1, PIK3CA, AKT1
31pd 98,059459.1BRAF, CTNNB1, PIK3CA, AKT1, EP300
32ly294002459.1BRAF, CTNNB1, PIK3CA, AKT1, EP300
33glycogen45 2410.1APC, CTNNB1, PIK3CA, AKT1, AXIN2
34paclitaxel45 50 1111.1BRAF, CTNNB1, PIK3CA, AKT1, BUB1B
35nmda45 2910.1APC, CTNNB1, PIK3CA, AKT1
36agar459.0BRAF, CTNNB1, PIK3CA, AKT1, NRAS
37cisplatin45 50 60 1112.0EP300, AKT1, PIK3CA, CTNNB1, BRAF
38rapamycin459.0BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1
39progesterone45 60 29 11 2412.9EP300, PIK3CA, CTNNB1, APC, BRAF
40wortmannin458.8BRAF, APC, CTNNB1, PIK3CA, AKT1, EP300
41vegf458.8BRAF, CTNNB1, PIK3CA, AKT1, EP300, FGFR3
42arginine458.8BRAF, CTNNB1, PIK3CA, AKT1, EP300, FGFR3
43doxorubicin45 50 1110.8CTNNB1, PIK3CA, AKT1, BUB1B, EP300, FGFR3
44testosterone45 60 11 2411.8APC, CTNNB1, PIK3CA, AKT1, EP300
45phosphatidylinositol458.8BRAF, APC, CTNNB1, PIK3CA, AKT1, EP300
46retinoic acid45 249.7BRAF, APC, CTNNB1, PIK3CA, AKT1, EP300
47oligonucleotide458.5BRAF, APC, CTNNB1, NRAS, IGH, FGFR3
48threonine458.2BRAF, APC, CTNNB1, PIK3CA, AKT1, AXIN2
49serine458.2BRAF, APC, CTNNB1, PIK3CA, AKT1, AXIN2
50tyrosine457.3BRAF, PDGFRL, APC, CTNNB1, PIK3CA, AKT1

GO Terms for genes affiliated with Colorectal Cancer, Somatic

Sources:
16Gene Ontology
See all sources

Cellular components related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308779.2AXIN2, CTNNB1, APC
2lamellipodiumGO:0300278.9APC, CTNNB1, PIK3CA, AKT1
3cytosolGO:0058297.5APC, CTNNB1, PIK3CA, AKT1, DCC, BUB1B
4plasma membraneGO:0058866.6BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1

Biological processes related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of Rho protein signal transductionGO:03502410.0DLC1, FLCN
2metaphase/anaphase transition of mitotic cell cycleGO:00709110.0BUB1B, APC
3positive regulation of peptidyl-serine phosphorylationGO:0331389.9AKT1, PIK3CA, BRAF
4striated muscle cell differentiationGO:0511469.8NRAS, AKT1
5positive regulation of protein phosphorylationGO:0019349.8FLCN, AKT1, AXIN2
6regulation of centromeric sister chromatid cohesionGO:0706029.7AXIN2, CTNNB1
7dorsal/ventral axis specificationGO:0099509.6AXIN2, CTNNB1
8phosphatidylinositol-mediated signalingGO:0480159.6FGFR3, BUB1B, AKT1, PIK3CA
9insulin receptor signaling pathwayGO:0082869.5PIK3CA, AKT1, NRAS, FGFR3
10Fc-epsilon receptor signaling pathwayGO:0380959.5PIK3CA, AKT1, NRAS, FGFR3
11epidermal growth factor receptor signaling pathwayGO:0071739.5PIK3CA, AKT1, NRAS, FGFR3
12lens morphogenesis in camera-type eyeGO:0020899.3FGFR3, CTNNB1
13positive regulation of ERK1 and ERK2 cascadeGO:0703749.3BRAF, DCC, FGFR3
14fibroblast growth factor receptor signaling pathwayGO:0085439.3BRAF, PIK3CA, AKT1, NRAS, FGFR3
15neurotrophin TRK receptor signaling pathwayGO:0480119.3BRAF, PIK3CA, AKT1, NRAS, FGFR3
16negative regulation of cell proliferationGO:0082858.9DLC1, AXIN2, CTNNB1, APC
17positive regulation of apoptotic processGO:0430658.6FGFR3, DCC, AKT1, FLCN, CTNNB1, APC
18innate immune responseGO:0450878.6CTNNB1, PIK3CA, AKT1, NRAS, EP300, FGFR3
19apoptotic processGO:0069158.0APC, CTNNB1, AKT1, DCC, BUB1B, EP300

Molecular functions related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin bindingGO:0080139.4APC, AXIN2, EP300
2protein serine/threonine kinase activityGO:0046749.2BUB1B, AKT1, PIK3CA, BRAF
3I-SMAD bindingGO:0704119.2AXIN2, CTNNB1
4protein bindingGO:0055156.1DLC1, BRAF, APC, CTNNB1, PIK3CA, FLCN

Products for genes affiliated with Colorectal Cancer, Somatic

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Colorectal Cancer, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet