Colorectal Cancer, Somatic disease: drugs, articles, genes, clinical trials

Summaries for Colorectal Cancer, Somatic

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³³OMIM, ²²MalaCards
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MalaCards: Colorectal Cancer, Somatic, also known as carcinoma of the large intestine, is related to familial colorectal cancer and colorectal cancer. An important gene associated with Colorectal Cancer, Somatic is FLCN (folliculin), and among its related pathways are Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1 and Apoptosis and survival_NGF signaling pathway. The compounds ptdins(3)p and o6-methylguanine have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

OMIM: 114500

Aliases & Descriptions for Colorectal Cancer, Somatic

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Sources:
³³OMIM, ⁴³UMLS
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colorectal cancer, somatic ³³

carcinoma of the large intestine ⁴³

Related Diseases for Colorectal Cancer, Somatic

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to colorectal cancer, somatic by text searches and GeneDecks gene sharing:

(show top 50) (show all 93)

id	Related Disease	Score	Top Affiliating Genes
1	familial colorectal cancer	29.5	PIK3CA, BRAF, MLH3, APC
2	colorectal cancer	28.9	DLC1, AKT1, APC, FGFR3, FLCN, MLH3
3	overgrowth syndrome	13.0	FGFR3, AKT1
4	ovarian cancer, somatic	13.0	AKT1, PIK3CA
5	breast cancer, somatic	13.0	PIK3CA, AKT1
6	gastric cancer, somatic	12.9	PIK3CA, APC
7	cowden disease	12.9	AKT1, PIK3CA
8	nonsmall cell lung cancer, somatic	12.8	PIK3CA, BRAF
9	pseudohypoparathyroidism	12.8	FGFR3, APC
10	plasma cell leukemia	12.8	BRAF, FGFR3
11	lung cancer, somatic	12.8	PIK3CA, BRAF
12	intestinal neoplasm	12.8	BRAF, APC
13	small intestine adenocarcinoma	12.8	BRAF, APC
14	lynch syndrome	12.8	BRAF, APC
15	ampulla of vater carcinoma	12.7	BRAF, PIK3CA
16	thyroid cancer	12.7	BRAF, APC
17	skin benign neoplasm	12.6	BRAF, FLCN, FGFR3
18	diffuse astrocytoma	12.6	BRAF, AKT1
19	focal cortical dysplasia	12.6	AKT1, PIK3CA
20	tuberous sclerosis	12.5	AKT1, FLCN, PIK3CA
21	kidney cancer	12.5	PIK3CA, BRAF, FLCN
22	adenoiditis	12.4	AKT1, FGFR3, PIK3CA
23	breast cancer	12.4	AKT1, APC, PIK3CA
24	leopard syndrome	12.4	PIK3CA, BRAF, AKT1
25	nonencapsulated sclerosing carcinoma	12.4	APC, FLCN, BRAF
26	thyroid cancer, anaplastic	12.3	BRAF, PIK3CA
27	testicular germ cell tumor	12.3	APC, FGFR3, BRAF
28	brain cancer	12.3	PIK3CA, APC, AKT1
29	mental retardation syndrome	12.3	BRAF, FGFR3, AKT1
30	thyroid adenoma	12.3	PIK3CA, BRAF, APC
31	malignant pleural mesothelioma	12.3	PIK3CA, BRAF, AKT1
32	ovarian mucinous neoplasm	12.3	PIK3CA, BRAF, APC
33	gastrointestinal stromal tumor	12.3	AKT1, BRAF, PIK3CA
34	endometrial adenocarcinoma	12.2	AKT1, BRAF, PIK3CA
35	hepatoblastoma	12.2	PIK3CA, APC, AKT1
36	germ cell tumor	12.1	APC, FGFR3, BRAF
37	pancreatic ductal adenocarcinoma	12.1	AKT1, APC, BRAF
38	neuroendocrine tumor	12.1	APC, BRAF, PIK3CA
39	hypertrophy of breast	12.0	AKT1, APC, FGFR3, PIK3CA
40	gout	12.0	PIK3CA, BRAF, FGFR3
41	renal cell carcinoma	12.0	PIK3CA, BRAF, FLCN, AKT1
42	chronic myeloid leukemia	11.9	AKT1, FGFR3, BRAF, PIK3CA
43	bartter disease	11.9	AKT1, FGFR3, BRAF, PIK3CA
44	nevus	11.9	APC, FGFR3, BRAF, PIK3CA
45	retinoblastoma	11.9	AKT1, APC, FGFR3, PIK3CA
46	boomerang dysplasia	11.9	PIK3CA, BRAF, FGFR3, APC
47	bladder carcinoma	11.9	APC, FGFR3, BRAF, PIK3CA
48	thyroid carcinoma	11.9	PIK3CA, BRAF, MLH3, APC
49	papillary thyroid carcinoma	11.8	AKT1, APC, BRAF, PIK3CA
50	non-small cell lung carcinoma	11.8	AKT1, APC, BRAF, PIK3CA

Graphical network of the top 20 diseases related to colorectal cancer, somatic:

Graphical network of diseases related to colorectal cancer, somatic

Clinical Features for Colorectal Cancer, Somatic

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Sources:
³³OMIM
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Clinical features from OMIM: 114500

Drugs & Therapeutics for Colorectal Cancer, Somatic

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials
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Approved drugs:

Search CenterWatch for colorectal cancer, somatic

Drug clinical trials:

Search ClinicalTrials for colorectal cancer, somatic

Search NIH Clinical Center for colorectal cancer, somatic

Search CenterWatch for colorectal cancer, somatic

Genetic Tests for Colorectal Cancer, Somatic

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Anatomical Context for Colorectal Cancer, Somatic

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Phenotypes for genes affiliated with Colorectal Cancer, Somatic

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²⁵MGI
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MGI Mouse Phenotypes related to colorectal cancer, somatic:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	adipose tissue phenotype	MP:0005375	8.5	PIK3CA, AKT1, BRAF, APC
2	endocrine/exocrine gland phenotype	MP:0005379	8.1	AKT1, APC, MLH3, PIK3CA, BRAF
3	reproductive system phenotype	MP:0005389	7.9	AKT1, APC, FGFR3, MLH3, PIK3CA
4	tumorigenesis	MP:0002006	7.9	AKT1, APC, BRAF, FGFR3, FLCN, PIK3CA
5	normal phenotype	MP:0002873	7.6	BRAF, DLC1, AKT1, FGFR3, APC
6	homeostasis/metabolism phenotype	MP:0005376	7.6	AKT1, APC, FLCN, FGFR3, BRAF, PIK3CA
7	growth/size phenotype	MP:0005378	7.5	PIK3CA, BRAF, FLCN, AKT1, APC, FGFR3
8	embryogenesis phenotype	MP:0005380	7.4	DLC1, AKT1, APC, BRAF, FLCN, PIK3CA
9	cardiovascular system phenotype	MP:0005385	7.4	APC, DLC1, AKT1, FLCN, BRAF, PIK3CA
10	nervous system phenotype	MP:0003631	7.2	AKT1, FGFR3, BRAF, APC, PIK3CA, DLC1
11	cellular phenotype	MP:0005384	7.0	DLC1, AKT1, APC, FGFR3, FLCN, BRAF
12	mortality/aging	MP:0010768	7.0	FLCN, FGFR3, APC, DLC1, BRAF, PIK3CA

Publications for genes affiliated with Colorectal Cancer, Somatic

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Genes related to Colorectal Cancer, Somatic

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¹³GeneCards
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Genes related to colorectal cancer, somatic according to GeneCards:

id	Symbol	Description	Score
1	FLCN	folliculin	11.0
2	MLH3	mutL homolog 3 (E. coli)	11.0
3	FGFR3	fibroblast growth factor receptor 3	11.0
4	AKT1	v-akt murine thymoma viral oncogene homolog 1	11.0
5	APC	adenomatous polyposis coli	11.0
6	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0
7	DLC1	deleted in liver cancer 1	11.0
8	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0

Expression for genes affiliated with Colorectal Cancer, Somatic

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Colorectal Cancer, Somatic

Pathways for genes affiliated with Colorectal Cancer, Somatic

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⁴¹Thomson Reuters, ¹⁰EMD Millipore, ³⁴PharmGKB, ³⁷R&D Systems, ³⁶QIAGEN, ²⁰KEGG
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Pathways related to colorectal cancer, somatic according to GeneDecks:

(show top 50) (show all 61)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1⁴¹	10.0	AKT1
2	Apoptosis and survival_NGF signaling pathway⁴¹	9.8	AKT1, PIK3CA
3	Apoptosis and survival NGF signaling pathway¹⁰	9.8	PIK3CA, AKT1
4	Development EGFR signaling via PIP3¹⁰	9.7	AKT1, PIK3CA
5	Pathway_PA165959425³⁴	9.7	AKT1, BRAF
6	Pathway_PA165980050³⁴	9.7	FGFR3, BRAF
7	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics³⁴	9.7	PIK3CA, AKT1
8	Immune response_IL-10 signaling pathway⁴¹	9.6	AKT1, PIK3CA
9	Immune response IL-23 signaling pathway¹⁰	9.6	PIK3CA, AKT1
10	G-protein signaling_K-RAS regulation pathway⁴¹	9.6	PIK3CA, BRAF
11	G-protein signaling K-RAS regulation pathway¹⁰	9.5	PIK3CA, BRAF
12	Development_FGF-family signaling⁴¹	9.5	AKT1, PIK3CA, FGFR3
13	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways³⁷	9.5	BRAF, AKT1
14	IL-2 Signaling Pathways³⁷	9.4	AKT1, BRAF
15	Immune response IL-10 signaling pathway¹⁰	9.4	AKT1, PIK3CA
16	P2Y Receptor Signaling³⁶	9.3	AKT1, FGFR3, BRAF
17	G-protein signaling_Cross-talk between Ras-family GTPases⁴¹	9.3	AKT1, BRAF, PIK3CA
18	G-protein signaling Cross-talk between Ras-family GTPases¹⁰	9.3	AKT1, PIK3CA, BRAF
19	Sorafenib Pharmacodynamics³⁴	9.3	AKT1, BRAF, PIK3CA
20	Development_Neurotrophin family signaling⁴¹	9.3	PIK3CA, BRAF, AKT1
21	Development Neurotrophin family signaling¹⁰	9.3	PIK3CA, BRAF, AKT1
22	Development_Thrombopoietin-regulated cell processes⁴¹	9.3	AKT1, BRAF, PIK3CA
23	Development Thrombopoietin-regulated cell processes¹⁰	9.3	PIK3CA, BRAF, AKT1
24	mTOR signaling pathway²⁰	9.3	AKT1, PIK3CA, BRAF
25	Non-small cell lung cancer²⁰	9.3	BRAF, PIK3CA, AKT1
26	eIF2 Pathway³⁶	9.3	AKT1, FGFR3, BRAF
27	Acute myeloid leukemia²⁰	9.3	AKT1, BRAF, PIK3CA
28	Development_A2B receptor- action via G-protein alpha s⁴¹	9.3	BRAF, PIK3CA, AKT1
29	Development A2B receptor- action via G-protein alpha s¹⁰	9.3	BRAF, PIK3CA, AKT1
30	Development A2A receptor signaling¹⁰	9.3	AKT1, BRAF, PIK3CA
31	Development_A2A receptor signaling⁴¹	9.3	BRAF, AKT1, PIK3CA
32	Glioma²⁰	9.3	PIK3CA, BRAF, AKT1
33	Melanoma²⁰	9.3	AKT1, BRAF, PIK3CA
34	Chronic myeloid leukemia²⁰	9.3	PIK3CA, AKT1, BRAF
35	Progesterone-mediated oocyte maturation²⁰	9.3	BRAF, PIK3CA, AKT1
36	ErbB signaling pathway²⁰	9.3	AKT1, PIK3CA, BRAF
37	Prostate cancer²⁰	9.2	BRAF, AKT1, PIK3CA
38	Glioblastoma Multiforme³⁶	9.2	BRAF, APC, AKT1
39	Neurotrophin signaling pathway²⁰	9.2	PIK3CA, BRAF, AKT1
40	Hepatitis C²⁰	9.2	AKT1, PIK3CA, BRAF
41	Insulin signaling pathway²⁰	9.2	AKT1, BRAF, PIK3CA
42	Colorectal Cancer Metastasis³⁶	9.2	BRAF, APC, AKT1
43	Chemokine signaling pathway²⁰	9.2	PIK3CA, BRAF, AKT1
44	Focal adhesion²⁰	9.2	PIK3CA, AKT1, BRAF
45	Nanog in Mammalian ESC Pluripotency³⁶	9.2	APC, FGFR3, BRAF
46	Regulation of actin cytoskeleton²⁰	8.8	APC, FGFR3, PIK3CA, BRAF
47	Endometrial cancer²⁰	8.8	APC, BRAF, AKT1, PIK3CA
48	Colorectal cancer²⁰	8.8	PIK3CA, AKT1, APC, BRAF
49	Signaling Involved in Cardiac Hypertrophy³⁶	8.7	AKT1, FGFR3, BRAF
50	Pathways in cancer²⁰	8.4	APC, AKT1, FGFR3, BRAF, PIK3CA

Compounds for genes affiliated with Colorectal Cancer, Somatic

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Sources:
³²Novoseek , ¹⁸HMDB, ⁴²Tocris Bioscience, ⁹DrugBank, ³⁴PharmGKB
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Compounds related to colorectal cancer, somatic according to GeneDecks:

(show all 24)

id	Compound	Score	Top Affiliating Genes
1	ptdins(3)p³²	9.8	AKT1, PIK3CA
2	o6-methylguanine³²	9.6	BRAF, APC
3	iodide³² ¹⁸	10.5	BRAF, PIK3CA
4	rapamycin³² ⁴²	10.4	BRAF, AKT1, FLCN
5	17-(allylamino)-17-demethoxygeldanamycin³²	9.4	AKT1, BRAF
6	guanine³² ⁹ ¹⁸ ⁹	12.3	FGFR3, APC, AKT1
7	thymine³² ¹⁸	10.2	APC, BRAF
8	imatinib³² ³⁴ ⁹ ⁹	12.2	PIK3CA, BRAF, FGFR3
9	crcs³²	9.2	BRAF, PIK3CA, APC
10	isoproterenol³² ⁹ ⁹	11.2	BRAF, APC, AKT1
11	agar³²	9.1	PIK3CA, BRAF, AKT1
12	matrigel³²	9.1	AKT1, BRAF, PIK3CA
13	paraffin³²	8.8	BRAF, FGFR3, AKT1, APC
14	wortmannin³² ⁴²	9.7	APC, AKT1, BRAF, PIK3CA
15	phosphoinositide³²	8.7	PIK3CA, BRAF, APC, AKT1
16	gtp³²	8.7	AKT1, APC, BRAF, PIK3CA
17	vegf³²	8.6	FGFR3, BRAF, AKT1, PIK3CA
18	arginine³²	8.6	AKT1, FGFR3, BRAF, PIK3CA
19	phosphatidylinositol³²	8.4	PIK3CA, BRAF, AKT1, APC
20	threonine³²	8.3	AKT1, PIK3CA, APC, FGFR3, BRAF
21	adp³² ¹⁸	9.3	BRAF, FGFR3, APC, AKT1, PIK3CA
22	lipid³²	8.2	PIK3CA, FGFR3, APC, BRAF, AKT1
23	glutamate³²	8.2	PIK3CA, BRAF, FGFR3, AKT1
24	serine³²	7.9	APC, AKT1, FGFR3, BRAF, PIK3CA

GO Terms for genes affiliated with Colorectal Cancer, Somatic

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¹²Gene Ontology
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Cellular components related to colorectal cancer, somatic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lamellipodium	GO:030027	9.0	PIK3CA, APC, AKT1

Biological processes related to colorectal cancer, somatic according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase B signaling cascade	GO:043491	9.4	AKT1, PIK3CA
2	insulin receptor signaling pathway	GO:008286	9.2	FGFR3, PIK3CA, AKT1
3	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.0	PIK3CA, BRAF, AKT1
4	negative regulation of apoptotic process	GO:043066	8.9	AKT1, APC, BRAF
5	anti-apoptosis	GO:006916	8.9	PIK3CA, AKT1, BRAF
6	fibroblast growth factor receptor signaling pathway	GO:008543	8.6	AKT1, FGFR3, BRAF, PIK3CA
7	nerve growth factor receptor signaling pathway	GO:048011	8.6	PIK3CA, BRAF, AKT1

Molecular functions related to colorectal cancer, somatic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:016301	9.5	PIK3CA, AKT1
2	ATP binding	GO:005524	7.8	AKT1, FGFR3, MLH3, BRAF, PIK3CA
3	protein binding	GO:005515	6.3	PIK3CA, DLC1, AKT1, APC, FGFR3, FLCN