MCID: CLR034
MIFTS: 40

Colorectal Cancer, Somatic malady

Cancer diseases category

Summaries for Colorectal Cancer, Somatic

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46OMIM, 32MalaCards
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MalaCards: Colorectal Cancer, Somatic is related to colorectal cancer and bladder carcinoma. An important gene associated with Colorectal Cancer, Somatic is MLH3 (mutL homolog 3), and among its related pathways are Regulation of Microtubule Cytoskeleton and Estrogen signaling pathway. The compounds resveratrol and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Description from OMIM:46 114500

Aliases & Classifications for Colorectal Cancer, Somatic

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

colorectal cancer, somatic 46


Related Diseases for Colorectal Cancer, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Colorectal Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer30.9BRAF, APC, CTNNB1, PIK3CA, EP300, FGFR3
2bladder carcinoma10.0FGFR3
3pituitary tumors10.0APC
4neuroblastoma10.0AKT1
5birt-hogg-dube syndrome10.0FLCN
6spitz nevus10.0BRAF
7pancreatitis10.0NRAS
8juvenile polyposis syndrome10.0APC
9intestinal neoplasm10.0APC
10multiple myeloma10.0AKT1, FGFR3
11glioblastoma multiforme10.0AKT1, PIK3CA
12seborrheic keratosis10.0PIK3CA, FGFR3
13myeloma10.0FGFR3, AKT1
14astrocytoma10.0PIK3CA, AKT1
15ovarian cancer, somatic10.0PIK3CA, AKT1
16breast cancer, somatic10.0PIK3CA, AKT1
17rhabdomyosarcoma10.0AKT1
18gastric cancer, somatic10.0APC, PIK3CA
19osteosarcoma10.0EP300
20gallbladder cancer10.0NRAS, APC
21skin benign neoplasm10.0FGFR3, FLCN, BRAF
22kidney rhabdoid cancer10.0BRAF, PIK3CA, FLCN
23noonan syndrome10.0BRAF, NRAS
24myelodysplastic syndromes10.0EP300, NRAS
25malignant glioma10.0AKT1, PIK3CA
26thyroid adenoma10.0PIK3CA, APC, BRAF
27lung cancer10.0NRAS, AKT1, PIK3CA
28nephroblastoma10.0CTNNB1
29short stature10.0BRAF, EP300, FGFR3
30cholangiocarcinoma10.0NRAS, PIK3CA, BRAF
31gardner syndrome10.0APC, CTNNB1
32thyroid cancer10.0BRAF, APC, PIK3CA, FGFR3
33sarcoma10.0EP300, NRAS, BRAF
34cervical cancer10.0FGFR3, EP300, PIK3CA, BRAF
35hepatocellular adenoma10.0APC, CTNNB1
36lynch syndrome10.0BRAF, APC, MLH3, NRAS
37kidney cancer10.0AKT1, FLCN, PIK3CA, BRAF
38turcot syndrome10.0APC, CTNNB1
39alzheimer's disease10.0AKT1, EP300, FGFR3
40thyroid cancer, anaplastic10.0PIK3CA, CTNNB1, BRAF
41hypertrophy of breast10.0APC, PIK3CA, AKT1, EP300, FGFR3
42hepatoblastoma10.0APC, CTNNB1, AXIN2
43retinoblastoma10.0APC, PIK3CA, AKT1, EP300, FGFR3
44papillary thyroid carcinoma10.0BRAF, APC, CTNNB1
45gastric adenocarcinoma10.0APC, CTNNB1, PIK3CA
46leukemia10.0FGFR3, EP300, NRAS, AKT1, PIK3CA
47mental retardation10.0BRAF, AKT1, EP300, FGFR3
48hepatocellular carcinoma10.0APC, CTNNB1, PIK3CA, AKT1, DLC1
49endometrial carcinoma10.0BRAF, CTNNB1, PIK3CA, AKT1, EP300
50breast cancer10.0APC, CTNNB1, PIK3CA, AKT1, EP300

Graphical network of the top 20 diseases related to Colorectal Cancer, Somatic:



Diseases related to colorectal cancer, somatic

Clinical Features for Colorectal Cancer, Somatic

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46OMIM
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Clinical features from OMIM:

114500

Drugs & Therapeutics for Colorectal Cancer, Somatic

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Colorectal Cancer, Somatic

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Anatomical Context for Colorectal Cancer, Somatic

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Animal Models for Colorectal Cancer, Somatic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Colorectal Cancer, Somatic:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.1AXIN2
2MP:00053679.7APC, FLCN, FGFR3
3MP:00053759.6BUB1B, APC
4MP:00053799.4PIK3CA, AKT1, MLH3, AXIN2
5MP:00053699.2EP300, BUB1B, APC, BRAF
6MP:00053809.1APC, FLCN, BUB1B, AXIN2, DLC1
7MP:00036319.1APC, DCC, AXIN2, DLC1
8MP:00053908.8FGFR3, AXIN2, BUB1B, AKT1, APC
9MP:00053918.8APC, DCC, BUB1B, AXIN2, FGFR3
10MP:00107718.5APC, CTNNB1, PIK3CA, AKT1, NRAS
11MP:00053888.4FGFR3, EP300, AKT1, CTNNB1
12MP:00053768.4PIK3CA, FLCN, AKT1, NRAS, BUB1B, EP300
13MP:00053898.3BRAF, APC, CTNNB1, PIK3CA, AKT1, MLH3
14MP:00053827.9BRAF, APC, CTNNB1, AXIN2, EP300, FGFR3
15MP:00053817.4BRAF, APC, CTNNB1, DCC, NRAS, EP300
16MP:00028737.4BRAF, APC, CTNNB1, AKT1, NRAS, AXIN2
17MP:00053876.9BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1
18MP:00053976.9BRAF, APC, CTNNB1, FLCN, AKT1, NRAS
19MP:00053786.6PIK3CA, CTNNB1, APC, BRAF, FLCN, AKT1
20MP:00053856.5BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1
21MP:00020066.4FGFR3, BRAF, APC, CTNNB1, PIK3CA, FLCN
22MP:00053846.0FLCN, PIK3CA, CTNNB1, APC, BRAF, AKT1
23MP:00107685.6FLCN, PIK3CA, CTNNB1, APC, BRAF, AKT1

Publications for Colorectal Cancer, Somatic

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Genetic Variations for Colorectal Cancer, Somatic

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Colorectal Cancer, Somatic:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Arg462IleVAR_018613
2BRAFp.Ile463SerVAR_018614
3BRAFp.Gly464GluVAR_018615
4BRAFp.Val600GluVAR_018629
5BRAFp.Lys601GluVAR_018630
6CTNNB1p.Ser33TyrVAR_017619
7MT-CO1p.Gly125AspVAR_064154
8MT-CO1p.Ser458ProVAR_064155
9PDGFRLp.His23TyrVAR_026052

Expression for genes affiliated with Colorectal Cancer, Somatic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Colorectal Cancer, Somatic

Search GEO for disease gene expression data for Colorectal Cancer, Somatic.

Pathways for genes affiliated with Colorectal Cancer, Somatic

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN, 29KEGG, 59Tocris Bioscience, 49PharmGKB, 52R&D Systems
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Pathways related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PIK3CA, APC, AKT1
29.6PIK3CA, AKT1, BRAF
3
G-protein signaling Cross-talk between Ras-family GTPases
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9.6AKT1, PIK3CA, BRAF
4
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9.4NRAS, PIK3CA, FGFR3
5
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9.4FGFR3, BRAF, NRAS
6
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9.4NRAS, FGFR3, BRAF
7
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9.2PIK3CA, NRAS, AKT1, FGFR3
8
Development FGF-family signaling
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9.2NRAS, FGFR3, AKT1, PIK3CA
99.1AKT1, CTNNB1, PIK3CA
10
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9.1NRAS, AKT1, PIK3CA, BRAF
11
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9.1NRAS, AKT1, PIK3CA, BRAF
129.1BRAF, AKT1, NRAS, PIK3CA
13
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9.1BRAF, AKT1, PIK3CA, NRAS
14
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9.1AKT1, CTNNB1, APC
15
Development Prolactin receptor signaling
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9.0EP300, NRAS, AKT1, PIK3CA
168.9CTNNB1, APC, AXIN2
17
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8.8AKT1, BRAF, NRAS, PIK3CA, FGFR3
188.8BRAF, CTNNB1, NRAS
19
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8.8NRAS, FGFR3, APC, PIK3CA, BRAF
20
Development A2B receptor- action via G-protein alpha s
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8.8BRAF, CTNNB1, PIK3CA, AKT1
21
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8.8BRAF, CTNNB1, PIK3CA, AKT1
22
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8.8CTNNB1, APC, BRAF, PIK3CA
238.8PIK3CA, FGFR3, EP300, APC, NRAS
24
Transcription Androgen Receptor nuclear signaling
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8.7AKT1, CTNNB1, PIK3CA, EP300
25
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8.7FGFR3, BRAF, NRAS, AKT1, EP300
26
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8.7FGFR3, EP300, NRAS, AKT1, BRAF
278.7AKT1, BRAF, EP300, CTNNB1
288.6EP300, AXIN2, CTNNB1, APC
298.5APC, CTNNB1, AKT1, NRAS
30
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8.5AKT1, BRAF, CTNNB1, NRAS
31
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8.3CTNNB1, AKT1, PIK3CA, NRAS, FGFR3
32
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8.3APC, CTNNB1, AXIN2, AKT1, EP300
33
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8.3EP300, APC, CTNNB1, AXIN2, AKT1
34
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8.3CTNNB1, BRAF, PIK3CA, NRAS, AKT1
358.3AKT1, PIK3CA, CTNNB1, NRAS, BRAF
36
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8.3BRAF, PIK3CA, AKT1, NRAS, CTNNB1
378.2AKT1, NRAS, BRAF, APC, CTNNB1
38
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8.0CTNNB1, AXIN2, NRAS, APC, EP300
39
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8.0APC, AKT1, DCC, BUB1B, CTNNB1
40
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8.0AKT1, FGFR3, NRAS, CTNNB1, APC, BRAF
41
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7.9DCC, AKT1, CTNNB1, EP300, NRAS
427.7AXIN2, BRAF, APC, CTNNB1, AKT1, DCC
43
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7.7NRAS, FGFR3, DCC, BRAF, AKT1, CTNNB1
44
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7.6BRAF, APC, EP300, CTNNB1, AKT1, NRAS
457.5AKT1, NRAS, PIK3CA, CTNNB1, EP300, BUB1B
467.3DCC, EP300, BUB1B, PIK3CA, CTNNB1, AKT1
47
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7.3EP300, NRAS, AKT1, FLCN, PIK3CA, BRAF
48
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7.0AKT1, FGFR3, EP300, NRAS, APC, BRAF
49
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6.9AKT1, PIK3CA, AXIN2, CTNNB1, APC, BRAF
506.3BRAF, DCC, NRAS, AXIN2, EP300, PIK3CA

Compounds for genes affiliated with Colorectal Cancer, Somatic

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.2EP300
2pge24410.2AKT1
3thymine44 2410.9APC, BRAF, EP300
41-hydroxyanthraquinone449.8APC, CTNNB1
5methylazoxymethanol acetate449.8CTNNB1, APC
61,2-dimethylhydrazine449.7CTNNB1, APC
7pidotimod449.7CTNNB1, AXIN2
8azoxymethane449.6CTNNB1, APC
9adp44 28 2411.5BUB1B, FGFR3, APC, AKT1
102-amino-3-methylimidazo(4,5-f)quinoline449.5APC, CTNNB1
11exisulind449.5APC, CTNNB1
12samp449.4AXIN2, CTNNB1, APC
13ag 1478449.4CTNNB1, AKT1, PIK3CA
14celecoxib44 59 28 49 11 2414.4APC, CTNNB1, AKT1
15sodium bisulfite449.4CTNNB1, APC
16gefitinib44 49 1111.3PIK3CA, CTNNB1, AKT1
17crcs449.2CTNNB1, APC, BRAF, PIK3CA
18imatinib44 49 1111.2BRAF, PIK3CA, FGFR3, CTNNB1
19guanine44 11 2411.2FGFR3, CTNNB1, APC, AKT1
20matrigel449.1AKT1, BRAF, CTNNB1, PIK3CA
21adriamycin449.1EP300, AKT1, CTNNB1
22curcumin449.1AKT1, EP300, CTNNB1, APC
23nocodazole44 1110.0AKT1, CTNNB1, APC, BUB1B
24nmda44 2810.0PIK3CA, APC, AKT1, CTNNB1
25tamoxifen44 49 28 1112.0EP300, AKT1, PIK3CA, CTNNB1
26sb 20358044 5910.0BRAF, CTNNB1, AKT1, EP300
27paraffin448.9BRAF, APC, CTNNB1, AKT1, FGFR3
28phosphoinositide448.9AKT1, PIK3CA, CTNNB1, APC, BRAF
29gtp44 289.9AKT1, CTNNB1, PIK3CA, BRAF, APC
30pd 98,059448.8EP300, BRAF, CTNNB1, PIK3CA, AKT1
31ly294002448.8EP300, PIK3CA, BRAF, AKT1, CTNNB1
32glycogen44 249.8PIK3CA, AKT1, APC, CTNNB1, AXIN2
33Adenosine triphosphate11 249.8BUB1B, AKT1, PIK3CA, FGFR3, BRAF
34cisplatin44 49 59 1111.8EP300, AKT1, PIK3CA, CTNNB1, BRAF
35paclitaxel44 49 1110.8AKT1, PIK3CA, CTNNB1, BRAF, BUB1B
36progesterone44 59 28 11 2412.7BRAF, CTNNB1, APC, PIK3CA, EP300
37testosterone44 59 11 2411.7CTNNB1, PIK3CA, AKT1, EP300, APC
38agar448.7AKT1, PIK3CA, NRAS, BRAF, CTNNB1
39rapamycin448.7FLCN, PIK3CA, BRAF, APC, CTNNB1, AKT1
40wortmannin448.5APC, CTNNB1, EP300, AKT1, PIK3CA, BRAF
41vegf448.5AKT1, FGFR3, EP300, PIK3CA, CTNNB1, BRAF
42arginine448.5CTNNB1, BRAF, AKT1, FGFR3, EP300, PIK3CA
43phosphatidylinositol448.5APC, EP300, BRAF, CTNNB1, PIK3CA, AKT1
44doxorubicin44 49 1110.5EP300, AKT1, PIK3CA, CTNNB1, BUB1B, FGFR3
45oligonucleotide448.5NRAS, BRAF, CTNNB1, APC, FGFR3
46retinoic acid44 249.4PIK3CA, AKT1, CTNNB1, BRAF, EP300, APC
47glutamine448.4CTNNB1, AKT1, APC, EP300
48threonine447.9CTNNB1, BRAF, PIK3CA, APC, AKT1, AXIN2
49serine447.9EP300, AXIN2, AKT1, PIK3CA, APC, BRAF
50tyrosine447.2FGFR3, PDGFRL, BRAF, EP300, NRAS, AKT1

GO Terms for genes affiliated with Colorectal Cancer, Somatic

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16Gene Ontology
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Cellular components related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308778.9AXIN2, CTNNB1, APC
2lamellipodiumGO:0300278.7APC, CTNNB1, PIK3CA, AKT1
3cytosolGO:0058297.1APC, CTNNB1, PIK3CA, AKT1, DCC, BUB1B
4plasma membraneGO:0058866.1BRAF, APC, CTNNB1, PIK3CA, FLCN, AKT1

Biological processes related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of Rho protein signal transductionGO:03502410.0DLC1, FLCN
2metaphase/anaphase transition of mitotic cell cycleGO:0070919.9BUB1B, APC
3positive regulation of peptidyl-serine phosphorylationGO:0331389.8AKT1, PIK3CA, BRAF
4positive regulation of protein phosphorylationGO:0019349.7FLCN, AKT1, AXIN2
5striated muscle cell differentiationGO:0511469.7NRAS, AKT1
6regulation of centromeric sister chromatid cohesionGO:0706029.5AXIN2, CTNNB1
7phosphatidylinositol-mediated signalingGO:0480159.5FGFR3, BUB1B, AKT1, PIK3CA
8insulin receptor signaling pathwayGO:0082869.4PIK3CA, AKT1, NRAS, FGFR3
9Fc-epsilon receptor signaling pathwayGO:0380959.4PIK3CA, AKT1, NRAS, FGFR3
10epidermal growth factor receptor signaling pathwayGO:0071739.4PIK3CA, AKT1, NRAS, FGFR3
11dorsal/ventral axis specificationGO:0099509.4AXIN2, CTNNB1
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.2BRAF, DCC, FGFR3
13fibroblast growth factor receptor signaling pathwayGO:0085439.1BRAF, PIK3CA, AKT1, NRAS, FGFR3
14neurotrophin TRK receptor signaling pathwayGO:0480119.1BRAF, PIK3CA, AKT1, NRAS, FGFR3
15lens morphogenesis in camera-type eyeGO:0020899.1FGFR3, CTNNB1
16negative regulation of cell proliferationGO:0082858.6DLC1, AXIN2, CTNNB1, APC
17positive regulation of apoptotic processGO:0430658.3FGFR3, DCC, AKT1, FLCN, CTNNB1, APC
18innate immune responseGO:0450878.2CTNNB1, PIK3CA, AKT1, NRAS, EP300, FGFR3
19apoptotic processGO:0069157.6APC, CTNNB1, AKT1, DCC, BUB1B, EP300

Molecular functions related to Colorectal Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin bindingGO:0080139.4APC, AXIN2, EP300
2I-SMAD bindingGO:0704119.1AXIN2, CTNNB1
3protein serine/threonine kinase activityGO:0046748.8BRAF, PIK3CA, AKT1, BUB1B
4ATP bindingGO:0055248.7FGFR3, BUB1B, MLH3, AKT1, PIK3CA, BRAF
5protein bindingGO:0055155.6DLC1, BRAF, APC, CTNNB1, PIK3CA, FLCN

Products for genes affiliated with Colorectal Cancer, Somatic

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  • Antibodies
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Sources for Colorectal Cancer, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet