CPHD
MCID: CMB021
MIFTS: 40

Combined Pituitary Hormone Deficiency (CPHD) malady

Endocrine diseases category

Summaries for Combined Pituitary Hormone Deficiency

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21Genetics Home Reference, 32MalaCards
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Genetics Home Reference:21 Combined pituitary hormone deficiency is a condition that causes a shortage (deficiency) of several hormones produced by the pituitary gland, which is located at the base of the brain. A lack of these hormones may affect the development of many parts of the body. The first signs of this condition include a failure to grow at the expected rate and short stature that usually becomes apparent in early childhood.

MalaCards: Combined Pituitary Hormone Deficiency, also known as panhypopituitarism, is related to panhypopituitarism and diabetes insipidus. An important gene associated with Combined Pituitary Hormone Deficiency is PROP1 (PROP paired-like homeobox 1), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Insulin Processing. The compounds estrogen and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include pituitary and brain, and related mouse phenotypes are hearing/vestibular/ear and adipose tissue.

Aliases & Classifications for Combined Pituitary Hormone Deficiency

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21Genetics Home Reference
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Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

combined pituitary hormone deficiency 21
panhypopituitarism 21
cphd 21


Related Diseases for Combined Pituitary Hormone Deficiency

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17GeneCards, 18GeneDecks
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Diseases related to Combined Pituitary Hormone Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1panhypopituitarism31.5TSHB, POMC, POU1F1, IGF1, PROP1, PRL
2diabetes insipidus30.8PRL, POMC
3pituitary hypoplasia30.7OTX2, POU1F1, PROP1, SOX3, HESX1, LHX3
4dwarfism30.5GH1, PROP1, IGFBP3, IGF1, POU1F1
5addison's disease30.3CRH, POMC
6empty sella syndrome30.3PRL, POMC
7septo-optic dysplasia30.2HESX1, SOD1
8pituitary apoplexy30.2POMC, PRL
9kallmann syndrome30.2LHX3, HESX1, PROP1, PROKR2, FGF8
10craniopharyngioma30.2POMC, IGF1, PROP1, PRL, GH1
11hypopituitarism30.2INS, POMC, POU1F1, IGF1, IGFBP3, PROP1
12hypothyroidism30.2TSHB, INS, POMC, POU1F1, IGF1, IGFBP3
13cushing's syndrome30.2CRH, GH1, POMC
14breast cancer30.1GH1, PRL, IGFBP3, IGF1, POU1F1, FGF8
15thyroiditis30.1POMC
16hypogonadism30.0INS, FGF8, POMC, POU1F1, CRH, GH1
17hypogonadotropism29.9PRL
18leukemia29.9PBX1
19lung cancer29.9IGF1, POMC
20sheehan syndrome29.9POMC, IGF1, PRL, CRH
21acromegaly29.9IGF1, IGFBP3, PRL, GH1
22hyperthyroidism29.9GH1, PRL, IGF1, INS, TSHB
23diabetes mellitus29.9SOD1, GH1, IGFBP3, IGF1, POMC, INS
24nephrotic syndrome29.7POMC
25azoospermia29.7PRL
26thyrotoxicosis29.7INS
27rheumatoid arthritis29.7CRH
28pituitary cancer29.7POMC, PRL
29infertility29.7INS, PRL
30pancreatitis29.7SOD1, INS
31amenorrhea29.7CRH, PRL, IGF1, POMC, INS
32anorexia nervosa29.7CRH, GH1, PRL, IGFBP3, IGF1, POMC
33pituitary adenoma29.7TSHB, PBX1, POMC, CRH, GH1, PRL
34obesity29.7PBX1, INS, POMC, IGF1, IGFBP3, PROP1
35adenoma29.7CRH, GH1, PRL, PROP1, IGFBP3, IGF1
36prop1-related combined pituitary hormone deficiency10.5
37non-acquired combined pituitary hormone deficiency10.4
38pituitary hormone deficiency, combined 110.3
39lhx4-related combined pituitary hormone deficiency10.3
40lhx3-related combined pituitary hormone deficiency10.3
41otx2-related combined pituitary hormone deficiency10.3
42pou1f1-related combined pituitary hormone deficiency10.3
43hesx1-related combined pituitary hormone deficiency10.3
44sensorineural hearing loss10.2
45situs inversus10.2
46hemangioma10.2
47kabuki syndrome10.2
48pituitary hormone deficiency, combined 310.2
49panhypopituitarism x-linked10.1
50central nervous system lymphoma10.1

Graphical network of the top 20 diseases related to Combined Pituitary Hormone Deficiency:



Diseases related to combined pituitary hormone deficiency

Clinical Features for Combined Pituitary Hormone Deficiency

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Drugs & Therapeutics for Combined Pituitary Hormone Deficiency

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Combined Pituitary Hormone Deficiency

Search CenterWatch for Combined Pituitary Hormone Deficiency

Genetic Tests for Combined Pituitary Hormone Deficiency

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Anatomical Context for Combined Pituitary Hormone Deficiency

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32MalaCards
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MalaCards organs/tissues related to Combined Pituitary Hormone Deficiency:

32
Pituitary, Brain

Animal Models for Combined Pituitary Hormone Deficiency or affiliated genes

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36MGI
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Publications for Combined Pituitary Hormone Deficiency

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Genetic Variations for Combined Pituitary Hormone Deficiency

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Expression for genes affiliated with Combined Pituitary Hormone Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Combined Pituitary Hormone Deficiency

Search GEO for disease gene expression data for Combined Pituitary Hormone Deficiency.

Pathways for genes affiliated with Combined Pituitary Hormone Deficiency

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49PharmGKB, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Combined Pituitary Hormone Deficiency

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Combined Pituitary Hormone Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6TSHB
2norepinephrine44 11 2412.2PRL, POMC
3quinagolide4410.0PRL, IGF1, GH1
4acth 1-244410.0POMC, PRL, CRH
5bromocriptine28 44 1111.9PRL, IGFBP3, POU1F1, POMC
611 deoxycortisol449.9PRL, CRH, POMC
7mecasermin44 1110.8INS, IGFBP3, IGF1
8lanreotide44 2810.8IGF1, IGFBP3, GH1, PRL
9fenfluramine28 44 1111.8CRH, PRL, IGFBP3, POMC
10dopamine44 28 11 2412.7IGF1, FGF8, CRH
11cabergoline28 44 1111.7IGFBP3, IGF1, PRL, GH1
125-hydroxytryptophan449.7CRH, GH1, PRL
13naloxone44 49 28 1112.7CRH, GH1, PRL, POMC
14oxandrolone44 1110.6IGFBP3, IGF1, INS, GH1
15pegvisomant44 1110.6IGF1, IGFBP3, GH1
16carbamazepine44 49 1111.6PRL, IGFBP3, POMC, CRH
17l-nmma449.5IGF1, GH1, CRH, SOD1
18pyridostigmine44 1110.5IGFBP3, GH1, CRH, PRL, IGF1
19opiate449.5CRH, PRL, POMC, GH1
2017-hydroxyprogesterone44 2410.5PRL, PBX1, CRH, POMC
21clonidine44 28 1111.5IGFBP3, POMC, IGF1, PRL, GH1
22megestrol acetate449.5POMC, IGF1, IGFBP3
23metformin44 49 1111.4GH1, IGF1, POMC, INS
24sulpiride44 28 1111.4PRL, GH1, CRH
25cortisone44 2410.4CRH, INS, GH1, IGF1, POMC
26c-peptide449.4INS, GH1, IGF1, IGFBP3
27gnrh449.3LHX3, PBX1, IGFBP3, PROP1, GH1, HESX1
28dehydroepiandrosterone sulfate449.3GH1, CRH, IGFBP3, POMC, PBX1
29triiodothyronine449.3IGFBP3, GH1, TSHB, POMC, IGF1, PRL
30ghrp449.3IGF1, PBX1, IGFBP3, PRL, GH1
31naltrexone44 49 28 1112.3POMC, IGF1, IGFBP3, PRL, GH1, CRH
32glycerol44 11 2411.2CRH, GH1, POMC, INS, IGFBP3
33clomiphene citrate449.2CRH, GH1, IGFBP3, IGF1, INS, PRL
34epinephrine44 11 2411.1POMC, CRH, GH1, IGFBP3, INS, PRL
35octreotide44 59 28 1111.9POMC, INS, IGF1, IGFBP3, CRH, PRL
36dhea448.9IGFBP3, INS, POMC, CRH, IGF1, PRL
37alanine448.9SOX3, CRH, GH1, POU1F1, SOD1, INS
38ribonucleic acid448.8POMC, CRH, IGFBP3, TSHB, GH1, POU1F1
39hexarelin44 289.8IGF1, IGFBP3, GH1, CRH, PRL, POMC
40thyroxine44 249.7TSHB, INS, POMC, IGFBP3, PRL, GH1
41estradiol44 11 2410.7PBX1, CRH, IGF1, GH1, PRL, POMC
42creatinine448.7GH1, CRH, IGF1, SOD1, IGFBP3, POMC
43hydrocortisone44 2 59 1111.7PBX1, POMC, IGF1, PRL, CRH, INS
44progesterone44 59 28 11 2412.5GH1, PBX1, CRH, PRL, IGFBP3, IGF1
45androstenedione44 249.4INS, CRH, PRL, GH1, IGFBP3, IGF1
46steroid448.4IGFBP3, PBX1, POU1F1, IGF1, PROP1, PRL
47dexamethasone44 49 28 1111.1GH1, IGF1, POU1F1, POMC, INS, CRH
48acth448.0PBX1, POMC, POU1F1, PRL, GH1, CRH
49arginine447.8POU1F1, INS, IGF1, PRL, IGFBP3, GH1
50testosterone44 59 11 2410.7CRH, PROP1, IGFBP3, PBX1, INS, FGF8

GO Terms for genes affiliated with Combined Pituitary Hormone Deficiency

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16Gene Ontology
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Cellular components related to Combined Pituitary Hormone Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.8INS, POMC
2insulin-like growth factor binding protein complexGO:0169429.6IGF1, IGFBP3
3extracellular spaceGO:0056157.8SOD1, CRH, GH1, IGFBP3, IGF1, POMC
4extracellular regionGO:0055767.4TSHB, SOD1, CRH, GH1, PRL, IGFBP3

Biological processes related to Combined Pituitary Hormone Deficiency according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1medial motor column neuron differentiationGO:02152610.4LHX3, LHX4
2parturitionGO:00756710.1CRH, PRL
3otic vesicle formationGO:03091610.1HESX1, FGF8
4placenta developmentGO:00189010.1LHX4, LHX3, SOD1
5positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0IGF1, IGFBP3, GH1
6regulation of ossificationGO:0302789.9PRL, PBX1
7regulation of multicellular organism growthGO:0400149.9SOD1, PRL, IGF1
8hypothalamus developmentGO:0218549.9CRH, SOX3
9positive regulation of glycolysisGO:0458219.8INS, IGF1
10forebrain morphogenesisGO:0488539.8HESX1, FGF8
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.8INS, IGF1, GH1
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8INS, IGF1, GH1
13positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF1
14positive regulation of MAPK cascadeGO:0434109.7IGFBP3, IGF1, INS
15response to ethanolGO:0454719.7PRL, CRH, SOD1
16positive regulation of JAK-STAT cascadeGO:0464279.7PRL, GH1
17organ morphogenesisGO:0098879.7PBX1, SOX3, LHX3, LHX4
18positive regulation of mitosisGO:0458409.6INS, FGF8, IGF1
19positive regulation of transcription from RNA polymerase II promoterGO:0459449.4LHX3, PROP1, IGF1, POU1F1, POMC, OTX2
20cellular protein metabolic processGO:0442679.2TSHB, INS, POMC, IGF1, IGFBP3
21positive regulation of cell proliferationGO:0082848.7CRH, IGF1, POU1F1, FGF8, INS, PBX1

Molecular functions related to Combined Pituitary Hormone Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.9PRL, GH1
2insulin-like growth factor receptor bindingGO:0051599.8INS, IGF1
3RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.3POU1F1, PBX1, OTX2
4sequence-specific DNA bindingGO:0435659.1LHX4, LHX3, HESX1, POU1F1, PBX1, OTX2
5sequence-specific DNA binding transcription factor activityGO:0037008.9LHX4, LHX3, HESX1, PROP1, POU1F1, PBX1
6hormone activityGO:0051798.7TSHB, CRH, GH1, PRL, IGF1, POMC

Products for genes affiliated with Combined Pituitary Hormone Deficiency

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Sources for Combined Pituitary Hormone Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet