MCID: CMM007
MIFTS: 24

Common Bile Duct Disease

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Common Bile Duct Disease

MalaCards integrated aliases for Common Bile Duct Disease:

Name: Common Bile Duct Disease 12 14
Common Bile Duct Diseases 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4137
MeSH 42 D003137
UMLS 69 C0009440

Summaries for Common Bile Duct Disease

MalaCards based summary : Common Bile Duct Disease, also known as common bile duct diseases, is related to kohler's disease and gastrointestinal adenoma. An important gene associated with Common Bile Duct Disease is SOBP (Sine Oculis Binding Protein Homolog). The drugs Acetaminophen and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 72 The common bile duct, sometimes abbreviated CBD, is a duct in the gastrointestinal tract of organisms... more...

Related Diseases for Common Bile Duct Disease

Diseases related to Common Bile Duct Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 kohler's disease 10.3 CTSC SOBP
2 gastrointestinal adenoma 10.3 CCK SOBP
3 perianal hematoma 10.3 CCK SOBP
4 anhidrosis 10.2 CCK CTSC
5 tricuspid valve stenosis 10.2 CCK NODAL
6 bile duct disease 10.0
7 orbital cancer 9.9 CCK GGT2
8 tuberculum sellae meningioma 9.9 CCK GGT2
9 hemorrhoid 9.8 CCK GGT2
10 pontocerebellar hypoplasia 9.8 CCK NODAL
11 intraorbital meningioma 6.3 CCK CTSC GGT2 LIX1 NODAL PNLIPRP1

Graphical network of the top 20 diseases related to Common Bile Duct Disease:



Diseases related to Common Bile Duct Disease

Symptoms & Phenotypes for Common Bile Duct Disease

GenomeRNAi Phenotypes related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.6 PNLIPRP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.6 NODAL
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 CTSC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 CTSC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.6 NODAL
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.6 PNLIPRP1 NODAL
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 CTSC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.6 PNLIPRP1 CTSC NODAL
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 NODAL
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.6 NODAL
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.6 NODAL
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.6 CTSC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 CTSC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 CTSC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.6 CTSC PNLIPRP1

Drugs & Therapeutics for Common Bile Duct Disease

Drugs for Common Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Clonidine Approved Phase 4 4205-90-7 2803
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
5
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
6
Morphine Approved, Investigational Phase 4 57-27-2 5288826
7
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
8
Secretin Approved, Investigational Phase 4 108153-74-8
9
Etomidate Approved Phase 4 33125-97-2 36339 667484
10
Meperidine Approved Phase 4 57-42-1 4058
11
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
12
Metronidazole Approved Phase 4 443-48-1 4173
13 Pinaverium Approved Phase 4 59995-65-2
14
Vancomycin Approved Phase 4 1404-90-6 441141 14969
15
Sorbitol Approved Phase 4 50-70-4 5780
16 Coconut Approved, Nutraceutical Phase 4
17 Tocopherol Approved, Nutraceutical Phase 4
18
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
19 Nefopam Investigational Phase 4 13669-70-0
20 Adjuvants, Anesthesia Phase 4
21 Analgesics Phase 4,Phase 3,Phase 2
22 Analgesics, Non-Narcotic Phase 4,Phase 2
23 Analgesics, Opioid Phase 4
24 Anesthetics Phase 4
25 Anesthetics, General Phase 4
26 Anesthetics, Intravenous Phase 4
27 Anesthetics, Local Phase 4
28 Antipyretics Phase 4
29 Central Nervous System Depressants Phase 4,Phase 2
30 Narcotics Phase 4
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
32 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
33 Psychotropic Drugs Phase 4,Phase 3,Phase 2
34 Tranquilizing Agents Phase 4,Phase 2
35 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1
36 Autonomic Agents Phase 4
37 Cholinergic Agents Phase 4
38 Cholinesterase Inhibitors Phase 4
39 Gastrointestinal Agents Phase 4
40 Hormone Antagonists Phase 4
41 Hormones Phase 4
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
43 Anti-Anxiety Agents Phase 4
44 GABA Agents Phase 4
45 GABA Modulators Phase 4
46 Hypnotics and Sedatives Phase 4
47 Anti-Infective Agents Phase 4
48 Antiparasitic Agents Phase 4
49 Antiprotozoal Agents Phase 4
50 Parasympatholytics Phase 4

Interventional clinical trials:

(show top 50) (show all 124)

id Name Status NCT ID Phase Drugs
1 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice Unknown status NCT00731419 Phase 4
4 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
5 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
6 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
7 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
8 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Recruiting NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
9 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Recruiting NCT02703077 Phase 4
10 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Recruiting NCT02605213 Phase 4 Vancomycin;Placebo
11 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
12 Compare the Knob-tipped Knife With the Needle Knife in Difficult Biliary Cannulation Unknown status NCT01745978 Phase 3
13 RFA RCT for Pancreatic or Bile Duct Cancer Unknown status NCT02166190 Phase 3
14 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
15 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
16 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
17 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
18 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
19 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method Recruiting NCT02916199 Phase 3
20 Endoscopic Biliary Radiofrequency Ablation of Malignant Distal Common Bile Duct Strictures Recruiting NCT01721174 Phase 2, Phase 3
21 Two Bilateral Metal Stenting in Hilar Malignancy Recruiting NCT01141088 Phase 3
22 Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction Active, not recruiting NCT00688662 Phase 3
23 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
24 Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
25 Role of Endoscopic RFA in Prolonging the Patency of Metal Stents in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
26 Prospective Phase II Trial on Prophylactic Perihepatic Lymphadenectomy in Patients With Colorectal Cancer With Liver Metastasis Completed NCT01565811 Phase 2
27 Trastuzumab in Treating Patients With Locally Advanced or Metastatic Gallbladder Cancer or Bile Duct Cancer That Cannot Be Removed by Surgery Completed NCT00478140 Phase 2
28 CPI-613 in Treating Patients With Advanced or Metastatic Bile Duct Cancer That Cannot Be Removed By Surgery Recruiting NCT01766219 Phase 1, Phase 2 6,8-bis(benzylthio)octanoic acid
29 Safety and Tumoricidal Effect of Low Dose Foscan PDT in Patients With Inoperable Bile Duct Cancers Recruiting NCT03003065 Phase 2 Temoporfin
30 Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery Withdrawn NCT01859182 Phase 2 selumetinib;Akt inhibitor MK2206
31 Optical Frequency Domain Imaging (OFDI) for Biliary Stricture Imaging Completed NCT01439620 Phase 1
32 Study of Irinotecan Administered as a Continuous Infusion and Radiation Therapy for Upper Gastrointestinal Cancers Completed NCT00183846 Phase 1 irinotecan
33 Cholestasis Prevention: Efficacy of IV Fish Oil Completed NCT00512629 Phase 1 Omegaven;Intralipid
34 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
35 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Active, not recruiting NCT01643499 Phase 1 oxaliplatin;irinotecan hydrochloride;leucovorin calcium;fluorouracil
36 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
37 A Comparison of Bile Duct Injuries Following Open Cholecystectomy Versus Laparoscopic Cholecystectomy Unknown status NCT00840138
38 Efficacy of Double Wire Technique in Difficult Cases of Common Bile Duct Cannulation in ERCP (UDOGUIA-04) Unknown status NCT00270868
39 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
40 Multibending vs Conventional Endoscope for Direct Peroral Cholangioscopy Unknown status NCT02189421
41 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581
42 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
43 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234
44 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatogr Unknown status NCT01414400
45 Endoscopic Treatment of Biliary Stricture Caused by Chronic Pancreatitis Unknown status NCT01085747
46 Risk Factors for Recurrence of Primary Bile Duct Stones Unknown status NCT02144493
47 Comparison Of Loop-Tip Wire Vs Tradictional Technique In The Cannulation Of The Common Bile Duct Unknown status NCT01771419
48 A Trial of Taurine Supplementation in Parenteral Nutrition 1 Unknown status NCT00135044
49 Biliary Candidiasis - Optimization of Diagnostics and Therapy Unknown status NCT01109550
50 Safety and Efficacy of a Newly Developed Baby-sphincterotome for Bile Duct Cannulation Completed NCT01493076

Search NIH Clinical Center for Common Bile Duct Disease

Cochrane evidence based reviews: common bile duct diseases

Genetic Tests for Common Bile Duct Disease

Anatomical Context for Common Bile Duct Disease

MalaCards organs/tissues related to Common Bile Duct Disease:

39
Liver

Publications for Common Bile Duct Disease

Articles related to Common Bile Duct Disease:

id Title Authors Year
1
Radiomanometry in the diagnosis of common bile duct disease. ( 4445925 )
1974
2
Radiomanometry, flow rates, and cholangiography in the evaluation of common bile duct disease. A study of 220 cases. ( 5058873 )
1972
3
The incidence of common bile duct disease following surgical exploration. ( 14352652 )
1955

Variations for Common Bile Duct Disease

Expression for Common Bile Duct Disease

Search GEO for disease gene expression data for Common Bile Duct Disease.

Pathways for Common Bile Duct Disease

GO Terms for Common Bile Duct Disease

Cellular components related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 8.62 CTSC SEC23B

Sources for Common Bile Duct Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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