MCID: CMM007
MIFTS: 23

Common Bile Duct Disease

Categories: Liver diseases, Gastrointestinal diseases

Aliases & Classifications for Common Bile Duct Disease

MalaCards integrated aliases for Common Bile Duct Disease:

Name: Common Bile Duct Disease 12 14
Common Bile Duct Diseases 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4137
MeSH 41 D003137
UMLS 69 C0009440

Summaries for Common Bile Duct Disease

MalaCards based summary : Common Bile Duct Disease, also known as common bile duct diseases, is related to bile duct disease and biliary dyskinesia. An important gene associated with Common Bile Duct Disease is SOBP (Sine Oculis Binding Protein Homolog). The drugs Morphine and Neostigmine have been mentioned in the context of this disorder. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 The common bile duct, sometimes abbreviated CBD, is a duct in the gastrointestinal tract of organisms... more...

Related Diseases for Common Bile Duct Disease

Diseases related to Common Bile Duct Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 bile duct disease 29.6 CCK GGT2
2 biliary dyskinesia 10.2 CCK SOBP
3 postcholecystectomy syndrome 10.2 CCK SOBP
4 duodenal disease 10.1 CCK NODAL
5 choledocholithiasis 10.0 CTSC NODAL SOBP
6 gallbladder disease 9.8 CCK NODAL
7 biliary tract disease 9.6 CCK GGT2

Graphical network of the top 20 diseases related to Common Bile Duct Disease:



Diseases related to Common Bile Duct Disease

Symptoms & Phenotypes for Common Bile Duct Disease

GenomeRNAi Phenotypes related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

25 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.6 PNLIPRP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.6 NODAL
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 CTSC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 CTSC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.6 NODAL
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.6 NODAL PNLIPRP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 CTSC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.6 CTSC NODAL PNLIPRP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 NODAL
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.6 NODAL
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.6 NODAL
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.6 CTSC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 CTSC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 CTSC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.6 CTSC PNLIPRP1

Drugs & Therapeutics for Common Bile Duct Disease

Drugs for Common Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
3
Secretin Approved, Investigational Phase 4 108153-74-8
4
Etomidate Approved Phase 4 33125-97-2 667484 36339
5
Meperidine Approved Phase 4 57-42-1 4058
6
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
7 Pinaverium Approved Phase 4 59995-65-2
8 Analgesics Phase 4,Phase 3,Phase 2
9 Central Nervous System Depressants Phase 4,Phase 2
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
12 Psychotropic Drugs Phase 4,Phase 3,Phase 2
13 Tranquilizing Agents Phase 4,Phase 2
14 Analgesics, Opioid Phase 4
15 Autonomic Agents Phase 4
16 Cholinergic Agents Phase 4
17 Cholinesterase Inhibitors Phase 4
18 Gastrointestinal Agents Phase 4
19 Hormone Antagonists Phase 4
20 Hormones Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
22 Narcotics Phase 4
23 Adjuvants, Anesthesia Phase 4
24 Anesthetics Phase 4
25 Anesthetics, General Phase 4
26 Anesthetics, Intravenous Phase 4
27 Anti-Anxiety Agents Phase 4
28 GABA Agents Phase 4
29 GABA Modulators Phase 4
30 Hypnotics and Sedatives Phase 4
31 Anticonvulsants Phase 4
32 Bromides Phase 4
33 calcium channel blockers Phase 4
34 Calcium, Dietary Phase 4
35 Parasympatholytics Phase 4
36
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
37
Norepinephrine Approved Phase 3 51-41-2 439260
38 Antidepressive Agents Phase 3,Phase 2
39 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
40 Dopamine Agents Phase 3
41 Duloxetine Hydrochloride Phase 3
42
Serotonin Phase 3 50-67-9 5202
43 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
44
Amitriptyline Approved Phase 2 50-48-6 2160
45
Perphenazine Approved Phase 2 58-39-9 4748
46 Adrenergic Agents Phase 2
47 Amitriptyline, perphenazine drug combination Phase 2
48 Analgesics, Non-Narcotic Phase 2
49 Antidepressive Agents, Tricyclic Phase 2
50 Antipsychotic Agents Phase 2

Interventional clinical trials:

(show all 47)

# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
3 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
4 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Recruiting NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
5 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
6 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
7 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
8 Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction Active, not recruiting NCT00688662 Phase 3
9 Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
10 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
11 A Comparison of Bile Duct Injuries Following Open Cholecystectomy Versus Laparoscopic Cholecystectomy Unknown status NCT00840138
12 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
13 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
14 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581
15 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
16 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatogr Unknown status NCT01414400
17 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234
18 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686
19 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475
20 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979
21 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method Completed NCT02916199
22 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
23 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958
24 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240
25 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845
26 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186
27 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269
28 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100
29 Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy Completed NCT00981604
30 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Recruiting NCT03190343
31 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286
32 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Recruiting NCT03074201
33 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474
34 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453
35 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
36 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059
37 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
38 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Enrolling by invitation NCT02276157
39 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
40 Pancreaticoduodenectomy With or Without Preoperative Hyperbaric Oxygen Therapy Enrolling by invitation NCT02575014 Preoperative hyperbaric oxygen
41 Early Precut in Difficult Biliary Cannulation Terminated NCT02596646
42 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846
43 Evaluation of Gastrointestinal Symptoms and Quality of Life in Patients With Sphincter of Oddi Dysfunction Terminated NCT01410071
44 Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy Terminated NCT01195285
45 Ultrasound for Diagnosis of Biliary Dyskinesia Terminated NCT00737295
46 Management of Common Bile Duct (CBD) Stones at Laparoscopic Cholecystectomy Terminated NCT00124033
47 Prospective Evaluation of the Covered Self-expandable Metal Stents (CSEMS) for Incomplete Biliary Stone Clearance Withdrawn NCT01475864

Search NIH Clinical Center for Common Bile Duct Disease

Cochrane evidence based reviews: common bile duct diseases

Genetic Tests for Common Bile Duct Disease

Anatomical Context for Common Bile Duct Disease

Publications for Common Bile Duct Disease

Articles related to Common Bile Duct Disease:

# Title Authors Year
1
Radiomanometry in the diagnosis of common bile duct disease. ( 4445925 )
1974
2
Radiomanometry, flow rates, and cholangiography in the evaluation of common bile duct disease. A study of 220 cases. ( 5058873 )
1972
3
The incidence of common bile duct disease following surgical exploration. ( 14352652 )
1955

Variations for Common Bile Duct Disease

Expression for Common Bile Duct Disease

Search GEO for disease gene expression data for Common Bile Duct Disease.

Pathways for Common Bile Duct Disease

GO Terms for Common Bile Duct Disease

Sources for Common Bile Duct Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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