Common Cold malady

MedlinePlus: Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases²³

MalaCards: Common Cold, also known as acute viral rhinopharyngitis, is related to chronic sphenoidal sinusitis and esophagitis. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine production by Th17 cells in CF and Malaria. The drugs cefuroxime and ciprofloxacin and the compounds hyaluronic acid and budesonide have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and respiratory system.

Disease Ontology: An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.⁶

CDC: Español: El resfriado común y la secreción nasal o moqueo²

Wikipedia: The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza, or a cold) is a viral...⁴⁴ more...

Aliases & Descriptions:

common cold 6 8 32 23 43 acute viral rhinopharyngitis 6 nasopharyngitis - acute 6 common cold (disorder) 6 nasopharyngitis, acute 6 acute nasopharyngitis 6 nasopharyngitis 43

rhino-sinusitis 6 head cold, nos 6 acute rhinitis 6 acute coryza 6 sinusitis 43

Diseases related to common cold by text searches and GeneDecks gene sharing:

(show top 50)    (show all 390)

id	Related Disease	Score	Top Affiliating Genes
1	chronic sphenoidal sinusitis	29.9	CFTR, IL5, IL8, CCL11, RNASE3
2	esophagitis	28.8	CFTR, IL5, IL8, CCL11, IFNA2, ICAM1
3	nasopharyngitis	28.6	MUC5B, IL5, IL8, CCL11, ICAM1, RNASE3
4	otitis media	28.5	MUC5B, IL5, IL8, CCL11, ICAM1, ALB
5	atopic dermatitis	28.4	SELP, IL5, IL8, CCL11, ICAM1, RNASE3
6	asthma	28.2	IL5, RNASE3, LTC4S
7	viral infectious disease	27.5	LDLR, IL8, CCL11, IFNA2, ICAM1
8	dermatitis	27.4	SELP, IL5, IL8, CCL11, IFNA2, ICAM1
9	polyposis	27.4	MUC5B, CFTR, IL5, IL8, CCL11, ICAM1
10	bronchiolitis	26.7	CHIA, MUC5B, IL1R1, IL5, IL8, CCL11
11	allergic bronchopulmonary aspergillosis	26.7	CFTR, IL5
12	diffuse panbronchiolitis	26.7	MUC5B, IL5, IL8
13	panbronchiolitis	26.7	MUC5B, IL5, IL8
14	sinusitis	26.6	SELP, MUC5B, CFTR, FLNC, IL5, IL8
15	influenza	26.6	LDLR, CFTR, IL5, IL8, CCL11, IFNA2
16	allergic rhinitis	26.6	IL5, IL8, CCL11, ICAM1, RNASE3
17	aspergillosis	26.1	CFTR, FLNC, IL1R1, IL5, ALB, RNASE3
18	hepatitis	26.0	SELP, IFNA2, ALB
19	thrombosis	25.7	SELP, LDLR, IL1R1, IL8, IFNA2, ICAM1
20	cervicitis	25.5	LDLR, MUC5B, CFTR, IL1R1, IL5, IL8
21	pneumonia	25.4	LDLR, CFTR, IL1R1, IL5, IL8, CCL11
22	herpes simplex	25.4	CFTR, IL1R1, IL8, IFNA2, ICAM1, ALB
23	cystic fibrosis	24.9	SELP, MUC5B, CFTR, FLNC, IL1R1, IL5
24	thyroiditis	24.8	SELP, LDLR, CFTR, FLNC, IL1R1, IL5
25	hodgkin's lymphoma	24.6	LDLR, IL5, IL8, IFNA2, ICAM1, ALB
26	cerebritis	24.6	SELP, VLDLR, LDLR, IL1R1, IL5, IL8
27	blindness	24.3	SELP, CFTR, IL1R1, IL5, IL8, CCL11
28	eosinophilia	24.3	CHIA, FLNC, IL5, IL8, CCL11, IFNA2
29	rhinitis	24.3	CHIA, IL1R1, IL5, IL8, CCL11, ICAM1
30	atopy	24.1	SELP, CFTR, IL5, IL8, CCL11, ICAM1
31	fibrosis	24.1	SELP, MUC5B, CFTR, FLNC, IL1R1, IL5
32	immunodeficiency	23.8	SELP, LDLR, IL1R1, IL5, IL8, CCL11
33	nephropathy	23.4	SELP, IL1R1, IL8, ICAM1, ALB, RNASE3
34	pulmonary disease	23.4	SELP, LDLR, MUC5B, CFTR, IL5, IL8
35	adenocarcinoma	22.9	SELP, VLDLR, LDLR, MUC5B, CFTR, IL1R1
36	melanoma	22.7	SELP, LDLR, CFTR, FLNC, IL1R1, IL5
37	henoch-schoenlein purpura	13.5	ICAM1, RNASE3
38	choroid cancer	13.5	KRTAP1-3, KRTAP1-1
39	carcinoma	13.5
40	cystic fibrosis lung disease	13.4	CFTR, IL8
41	helminthiasis	13.3	IL5, RNASE3
42	cough variant asthma	13.2	IL5, RNASE3
43	respiratory failure	13.2	CFTR, CCL11, RNASE3
44	exanthem	13.2	IL5, CCL11
45	bagassosis	13.2	IL5, IL8
46	bronchiolitis obliterans organizing pneumonia	13.2	IFNA2, ALB
47	pyoderma gangrenosum	13.2	IL1R1, IL8, IFNA2
48	interstitial lung disease	13.2	IL1R1, IL8, CCL11
49	giant papillary conjunctivitis	13.2	IL5, CCL11, RNASE3
50	chronic eosinophilic pneumonia	13.2	IL5, CCL11, RNASE3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alatrofloxacin, alatrofloxacin mesylate, amoxicillin, amoxicillin trihydrate, ascorbic acid, ascorbic acid pwdr [va product], cefdinir, cefprozil, cefuroxime, cefuroxime axetil, cefuroxime sodium, ciprofloxacin, ciprofloxacin hydrochloride, clarithromycin, dexbrompheniramine, dexbrompheniramine maleate, gatifloxacin, guaifenesin, loracarbef, moxifloxacin, moxifloxacin hcl, naphazoline, naphazoline hydrochloride, penicillin v potassium, phenylpropanolamine, phenylpropanolamine hydrochloride, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, sodium ascorbate, tetrahydrozoline, tetrahydrozoline hydrochloride, trovafloxacin, trovafloxacin mesylate, zinc (as gluconate), zinc (as sulfate), zinc acetate, zinc chloride, zinc gluconate, zinc sulfate, zinc sulfate pwdr [va product]

MGI Mouse Phenotypes related to common cold:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.6	SELP, LDLR, CFTR, LTC4S
2	respiratory system phenotype	MP:0005388	7.3	CCL11, IL5, IL1R1, FLNC, CFTR, SELP

Articles related to common cold:

id	Title	Authors	Year	Affiliating Genes
1	Inflammatory changes during the 'common cold' are associated with platelet activation and increased reactivity of platelets to agonists. (17982310)	Kreutz R.P.... Gurbel P.A.	2007	SELP
2	Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules. (15950998)	Moser R.... Blaas D.	2005	VLDLR
3	Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus a21. (14734451)	Shafren D.R.... Barry R.D.	2004	ICAM1
4	The common cold as a trigger of asthma. (11272635)	Mygind N.	2000	IL8
5	The common cold at the turn of the millennium. (11068660)	Van Cauwenberge P.B.... Bachert C.	2000	IL8
6	Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. (10929163)	Prasad A.S.... Chandrasekar P.H.	2000	IL1R1
7	Allergen challenge-induced acute exudation of IL-8, ECP and alpha2-macroglobulin in human rhinovirus-induced common colds. (10836321)	Greiff L.... Persson C.G.	1999	IL8, RNASE3
8	Experimental common cold increases mucosal output of eotaxin in atopic individuals. (10604558)	Greiff L.... Persson C.G.	1999	CCL11
9	Day-night differences in mucosal plasma proteins in common cold. (8820357)	Greiff L.... Persson C.G.	1996	ALB
10	Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus. (8127891)	Hofer F.... Blaas D.	1994	LDLR

Genes related to common cold according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	IFNA2	interferon, alpha 2	11.1	Summaries
2	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
3	ICAM1	intercellular adhesion molecule 1	11.0	Publications
4	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
5	IL8	interleukin 8	11.0	Publications
6	SCGB1D4	secretoglobin, family 1D, member 4	11.0	Disorders
7	SCGB1C1	secretoglobin, family 1C, member 1	11.0	Disorders
8	KRTAP1-3	keratin associated protein 1-3	11.0	Disorders
9	KRTAP1-1	keratin associated protein 1-1	11.0
10	PLA2G2E	phospholipase A2, group IIE	11.0
11	FLNC	filamin C, gamma	11.0
12	CHIA	chitinase, acidic	11.0
13	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0
14	LTC4S	leukotriene C4 synthase	11.0
15	VLDLR	very low density lipoprotein receptor	11.0	Publications
16	LDLR	low density lipoprotein receptor	11.0	Publications
17	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
18	AOAH	acyloxyacyl hydrolase (neutrophil)	11.0
19	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0
20	IL1R1	interleukin 1 receptor, type I	11.0	Publications
21	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0
22	ALB	albumin	11.0	Publications

Pathways related to common cold according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Cytokine production by Th17 cells in CF41	9.7	CFTR, IL8, ICAM1
2	Malaria20	9.6	SELP, IL8, ICAM1
3	Asthma20	9.5	IL5, CCL11, RNASE3
4	Cytokine Network36	9.5	IL5, IL8, IFNA2
5	Immune response_Bacterial infections in normal airways41	9.2	CFTR, IL1R1, IL8
6	Bacterial infections in CF airways41	9.2	IL8, IL1R1, CFTR
7	all-trans-Retinoic Acid Signaling in Brain36	9.1	LTC4S, CCL11, IL8, IL5
8	PGC1Alpha Pathway36	8.8	CCL11, IL8, IL5, IL1R1
9	Cytokine-cytokine receptor interaction20	8.7	IFNA2, CCL11, IL8, IL5, IL1R1
10	STAT3 Pathway36	8.6	IL1R1, IL5, IL8, CCL11
11	JAK-STAT Pathway36	8.5	IFNA2, CCL11, IL8, IL5, IL1R1
12	Antioxidant Action of Vitamin-C36	8.4	FLNC, PLA2G2E, CCL11, IL8, IL5, IL1R1
13	Glucocorticoid Receptor Signaling36	8.3	CCL11, IL8, IL5, IL1R1

Compounds related to common cold according to GeneDecks:

(show top 50)    (show all 107)

id	Compound	Score	Top Affiliating Genes
1	hyaluronic acid32 18	11.7	RNASE3
2	budesonide32 42 9 9	13.6	CCL11, RNASE3
3	anti-histamine32	10.2	RNASE3, ICAM1, CCL11
4	loratadine32 9 18 9	13.1	ICAM1, RNASE3, IL8
5	heparin32 9 18 9	12.7	CCL11, ALB, VLDLR, RNASE3
6	sele32	9.7	SELP, LDLR, ICAM1
7	unicap32	9.6	RNASE3, CCL11, IL5
8	levocabastine32 9 9	11.6	IL5, ICAM1, RNASE3
9	endotoxin32	9.6	CCL11, AOAH, IL1R1
10	roxithromycin32 9 9	11.5	CCL11, IL8, IL5
11	sodium cromoglycate32	9.5	CCL11, ICAM1, RNASE3, IL5
12	nedocromil sodium32	9.5	ICAM1, IL5, RNASE3, IL8
13	ccl332	9.5	IL8, IL1R1, ICAM1, CCL11
14	ketotifen32 9 9	11.5	ICAM1, CCL11, IL5, RNASE3
15	salmeterol32 42 9 9	12.5	IL5, IL8, CCL11, RNASE3
16	pranlukast32 9 9	11.5	RNASE3, CCL11, IL5
17	fluticasone propionate32 42 9 9	12.4	RNASE3, CCL11, IL8, IL5
18	salbutamol32 34 9 18 9	13.4	IL5, IL8, CCL11, RNASE3
19	lte432	9.4	LTC4S, RNASE3, CCL11, IL5
20	vegf32	9.4	IL1R1, SELP, RNASE3, ICAM1
21	cetirizine32 9 18 9	12.3	RNASE3, CCL11, IL8, IL5, ICAM1
22	tarc32	9.3	IL5, IL8, ICAM1, CCL11
23	ltc432	9.3	IL5, LTC4S, RNASE3, CCL11
24	methacholine32 9 9	11.3	ICAM1, RNASE3, IL5, CCL11, IL8
25	neopterin32	9.3	IFNA2, IL8, IL1R1, ICAM1
26	pgd232	9.3	IL5, CCL11, RNASE3, LTC4S
27	pentoxifylline32 9 9	11.3	ICAM1, IL8, SELP, IL1R1
28	montelukast32 34 9 9	12.2	IL8, CCL11, RNASE3, LTC4S, IL5
29	ascorbic acid32 18	10.1	LDLR, IL1R1, IFNA2, CFTR
30	n-formylmethionyl-leucylphenylalanine32	8.9	IL8, RNASE3, ICAM1, CCL11, SELP, IL5
31	fmlp32	8.9	ICAM1, IL8, IL5, CCL11, SELP, RNASE3
32	n acetylcysteine32	8.6	CFTR, IL8, ICAM1, RNASE3, SELP, IL1R1
33	dextran sulfate32	8.6	SELP, ALB, ICAM1, IL5, LDLR
34	salicylic acid32	8.5	CFTR, IL5, ALB, ICAM1
35	actinomycin d32	8.4	CFTR, IL1R1, LDLR, IL8, ICAM1, CCL11
36	prednisolone32 9 9	10.4	ALB, IFNA2, RNASE3, IL1R1, IL5, CCL11
37	aspirin32 34 18	10.3	LTC4S, RNASE3, LDLR, CCL11, IL1R1, CFTR
38	arachidonic acid32 9 18 9	11.2	LTC4S, PLA2G2E, IFNA2, IL1R1, SELP, ALB
39	leukotriene b432 42 18	10.2	SELP, IL5, IL8, CCL11, RNASE3, IL1R1
40	genistein32 9 18 9	11.1	ICAM1, SELP, LDLR, CFTR, IL5, IL8
41	rantes32	8.0	RNASE3, SELP, CHIA, IL1R1, IL5, IL8
42	histamine32 18	8.9	SELP, IFNA2, CCL11, IL8, ICAM1, ALB
43	indomethacin32 9 9	9.6	IFNA2, LDLR, CCL11, IL5, ALB, IL1R1
44	h2o232	7.5	IL1R1, IL8, ICAM1, LDLR, RNASE3, IL5
45	cyclosporin a32 42	8.4	RNASE3, ICAM1, CCL11, IL8, IL5, IL1R1
46	retinoic acid32 42 18	9.3	CFTR, RNASE3, IL1R1, IL5, CCL11, ICAM1
47	lipid32	7.2	LDLR, CHIA, IL1R1, CCL11, IFNA2, ALB
48	pge232	7.1	LTC4S, CCL11, IL8, IL5, SELP, IL1R1
49	dexamethasone32 42 34 9 9	11.1	SELP, IL8, LDLR, CFTR, CCL11, ICAM1
50	cysteine32	6.8	ALB, IFNA2, IL8, IL5, CFTR, LDLR

Cellular components related to common cold according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.7	ICAM1, IFNA2, CCL11, IL8, IL5, CHIA
2	extracellular region	GO:005576	5.5	SCGB1C1, KRTAP1-1, KRTAP1-3, RNASE3, PLA2G2E, ALB

Biological processes related to common cold according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to interleukin-1	GO:071347	9.4	VLDLR, IL8, ICAM1
2	cellular response to lipopolysaccharide	GO:071222	9.3	LTC4S, ICAM1, IL8, VLDLR
3	immune response	GO:006955	8.4	IL8, IL5, IL1R1, CHIA, CCL11
4	inflammatory response	GO:006954	8.0	SELP, IL5, IL8, AOAH, CCL11, IFNA2

Molecular functions related to common cold according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	low-density lipoprotein receptor activity	GO:005041	9.8	VLDLR, LDLR
2	very-low-density lipoprotein particle receptor activity	GO:030229	9.7	VLDLR, LDLR
3	glycoprotein binding	GO:001948	9.0	SELP, VLDLR, LDLR