MCID: CMM005
MIFTS: 55

Common Cold malady

Respiratory category

Summaries for Common Cold

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards: Common Cold, also known as acute viral rhinopharyngitis, is related to asthma and sinusitis. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Spinal Cord Injury and TGF-Beta Pathway. The drugs sodium ascorbate and pseudoephedrine and the compounds anti-histamine and unicap have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and monocytes, and related mouse phenotype immune system.

Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC:3 Español: El resfriado común y la secreción nasal o moqueo

Wikipedia:64 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza, head cold, or simply a... more...

Aliases & Classifications for Common Cold

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

common cold 8 10 45 34 61
acute viral rhinopharyngitis 8
nasopharyngitis - acute 8
nasopharyngitis, acute 8
acute nasopharyngitis 8
rhino-sinusitis 8
acute rhinitis 8
head cold, nos 8
acute coryza 8


External Ids:

Disease Ontology8 DOID:10459
ICD9CM27 460
MeSH35 D003139
ICD1025 J00

Related Diseases for Common Cold

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Common Cold via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1asthma30.7IL5, RNASE3, LTC4S
2sinusitis30.5CCL11, FLNC, LTC4S, MUC5B, RNASE3, IL5
3allergic rhinitis30.4CCL11, ICAM1, RNASE3, IL5, IL8
4pulmonary disease, chronic obstructive29.9MUC5B
5bronchitis29.9CCL11, RNASE3, IL5, IL8
6viral infectious disease29.9CCL11, IFNA2, ICAM1, IL8, LDLR
7cystic fibrosis29.9FLNC, MUC5B, RNASE3, IL1R1, IL8
8nasopharyngitis10.2
9tonsillitis10.0
10acute myocarditis10.0
11nephrotic syndrome10.0CCL11
12pulmonary fibrosis10.0IL8
13malaria10.0ICAM1
14galactosemia10.0ICAM1
15conjunctivitis10.0RNASE3
16pemphigus vulgaris10.0CCL11
17myositis10.0ICAM1
18diabetic retinopathy10.0ICAM1
19respiratory failure10.0ICAM1
20liver cirrhosis10.0IFNA2
21dermatitis herpetiformis10.0CCL11
22hypertension10.0ICAM1
23meningitis10.0IL8
24graves' disease10.0ICAM1
25deficiency anemia10.0IFNA2
26hypersensitivity reaction type ii disease10.0ICAM1
27nephritis10.0IL1R1
28bronchiolitis obliterans10.0IL8
29atopic dermatitis10.0RNASE3, CCL11
30aspergillosis10.0FLNC
31mastitis10.0IL8
32urticaria10.0RNASE3, LTC4S
33thromboembolism10.0SELP
34migraine10.0LDLR
35periodontitis10.0IL8
36hepatitis b10.0IFNA2
37lichen planus10.0ICAM1, IFNA2
38stroke, ischemic10.0SELP
39acute pancreatitis10.0IL8, IL1R1
40alcoholic hepatitis10.0IL8, ICAM1
41muckle-wells syndrome10.0IL1R1
42alopecia areata10.0ICAM1, IL1R1
43immunoglobulin a vasculitis10.0ICAM1, RNASE3
44adenocarcinoma10.0LDLR
45choroid cancer10.0KRTAP1-1, KRTAP1-3
46severe combined immunodeficiency10.0IL5
47dementia10.0VLDLR
48gastritis10.0IL8, MUC5B
49insulin resistance10.0CCL11, LDLR
50glomerulonephritis10.0IL1R1, ICAM1

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Clinical Features for Common Cold

Drugs & Therapeutics for Common Cold

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Common Cold

Anatomical Context for Common Cold

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Common Cold:

33
Skin, Lung, Monocytes, T cells, B cells

Animal Models for Common Cold or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Common Cold:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2LDLR, SELP, IL8, IL1R1, IL5, LTC4S

Publications for Common Cold

Sources:
51PubMed
See all sources

Articles related to Common Cold:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Appropriateness of prescriptions for common cold. (22678521)
2013
2
Parenthood, host resistance to the common cold, and impaired fertility. (23107840)
2012
3
Oral antihistamine-decongestant-analgesic combinations for the common cold. (22336807)
2012
4
African geranium (EPs 7630), part I: a proprietary root extract of Pelargonium sidoides (EPs 7630) is found to be effective in resolving symptoms associated with the common cold in adults. (22343933)
2012
5
North American (Panax quinquefolius) and Asian Ginseng (Panax ginseng) Preparations for Prevention of the Common Cold in Healthy Adults: A Systematic Review. (19592479)
2011
6
Fixed-dose combinations for cough and common cold in India: an assessment of availability and rationality. (20584201)
2011
7
Clinical potential of zinc in prophylaxis of the common cold. (21702650)
2011
8
Bacterial pathogens of acute sinusitis in the osteomeatal complex during common colds and wellness. (22287466)
2011
9
Early ischemic lesions following subarachnoid hemorrhage: common cold remedy as precipitating factor? (21510236)
2011
10
A cure for the common cold. (21058622)
2010
11
Non-steroidal anti-inflammatory drugs for the common cold. (19588387)
2009
12
Viral etiology of common cold in children, Finland. (19193292)
2009
13
Do Japanese style acupuncture and moxibustion reduce symptoms of the common cold? (18955215)
2008
14
Cross-cultural perspectives on physician and lay models of the common cold. (18717364)
2008
15
Gas-phase electrophoretic molecular mobility analysis of size and stoichiometry of complexes of a common cold virus with antibody and soluble receptor molecules. (18260676)
2008
16
Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. (17597571)
2007
17
Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. (18005909)
2007
18
Nasal decongestants for the common cold. (17253470)
2007
19
Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial. (16454145)
2006
20
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. (16882099)
2006
21
Rhinovirus infections: more than a common cold. (17158286)
2006
22
Echinacea treatment for the common cold. (15736013)
2005
23
Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality? (16303679)
2005
24
Managing the common cold. (15754658)
2005
25
A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold. (16323289)
2005
26
Discolored nasal discharge did not increase the antibiotic prescription rate for the common cold patients. (15386698)
2005
27
Treatment of the common cold with troxerutin. (15601310)
2004
28
Knowledge and beliefs of primary care physicians, pharmacists, and parents on antibiotic use for the pediatric common cold. (14652058)
2004
29
Zinc nasal gel effective for the common cold. (12737760)
2003
30
Intake of vitamin C and zinc and risk of common cold: a cohort study. (11805584)
2002
31
Influence of attendance at day care on the common cold from birth through 13 years of age. (11814371)
2002
32
Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey. (12201356)
2002
33
Osteopathic treatment of the common cold. 1937. (11534526)
2001
34
Detection by reverse transcription-polymerase chain reaction of influenza C in nasopharyngeal secretions of adults with a common cold. (11262210)
2001
35
A cohort study of stress and the common cold. (11338315)
2001
36
Mega-dose vitamin C in treatment of the common cold: a randomised controlled trial. (11700812)
2001
37
Depressive state and common cold. (11036920)
2000
38
Evaluation of echinacea for treatment of the common cold. (10853625)
2000
39
The common cold. (9866136)
1998
40
Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): relationship to symptoms of the common cold and studying behavior. (9494693)
1998
41
A cure for the common cold? Zinc again. (9643866)
1998
42
Radiological maxillary sinusitis in patients with common cold. (9673613)
1998
43
Common cold and high-dose ipratropium bromide: use of anticholinergic medication as an indicator of reflex-mediated hypersecretion. (9299652)
1997
44
Vitamin C supplementation and the common cold--was Linus Pauling right or wrong? (9350474)
1997
45
Vitamin C intake and susceptibility to the common cold. (9059230)
1997
46
Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. (8684101)
1996
47
Vitamin C supplementation and common cold symptoms: problems with inaccurate reviews. (8974108)
1996
48
Consumer attitudes towards computer-assisted self-care of the common cold. (7971542)
1994
49
Negative life events, perceived stress, negative affect, and susceptibility to the common cold. (8421249)
1993
50
Vitamin C: from scurvy to the common cold. (6342385)
1983

Genetic Variations for Common Cold

Expression for genes affiliated with Common Cold

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Common Cold

Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Common Cold according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL1R1, ICAM1
2
Hide members
10.0IL5, CCL11
3
Hide members
10.0IL5, CCL11
49.9ICAM1, IL1R1, IL8
59.8IFNA2, IL5, IL8
69.8CCL11, IL5, IL8
79.8ICAM1, IL5, IL8
89.7CCL11, IL5, SELP
9
Hide members
9.6IL1R1, IL5, ICAM1, IFNA2
10
Hide members
9.4IL5, RNASE3, ICAM1, IFNA2, CCL11
11
Hide members
9.1PLA2G2E, IL5, ICAM1, IFNA2, CCL11
12
Hide members
8.8CCL11, FLNC, IL5, IL1R1, IL8, PLA2G2E

Compounds for genes affiliated with Common Cold

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Common Cold according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1anti-histamine4510.3CCL11, ICAM1, RNASE3
2unicap4510.2RNASE3, IL5, CCL11
3loratadine45 11 2412.2ICAM1, RNASE3, IL8
4endotoxin4510.2ICAM1, AOAH, RNASE3
5levocabastine45 29 1112.1IL5, ICAM1, RNASE3
6roxithromycin45 29 1112.1IL8, CCL11, IL5
7sodium cromoglycate4510.0CCL11, IL5, ICAM1, RNASE3
8lte44510.0IL5, LTC4S, CCL11, RNASE3
9salmeterol45 50 29 1113.0IL8, RNASE3, CCL11, IL5
10ketotifen45 1111.0RNASE3, ICAM1, CCL11, IL5
11nedocromil sodium4510.0RNASE3, ICAM1, IL8, IL5
12pranlukast45 29 1112.0IL5, CCL11, RNASE3
13salbutamol45 50 29 11 2414.0RNASE3, CCL11, IL5, IL8
14ccl345 2911.0ICAM1, IL1R1, IL8, CCL11
15ltc44510.0RNASE3, LTC4S, CCL11, IL5
16fluticasone propionate45 50 60 1113.0CCL11, RNASE3, IL8, IL5
17azelastine45 1111.0ICAM1, RNASE3, IL5
18pgd2459.9IL5, RNASE3, LTC4S, CCL11
19sele459.9ICAM1, SELP, LDLR
20tarc459.9ICAM1, CCL11, IL8, IL5
21ltd4459.9IL5, LTC4S, RNASE3
22neopterin459.9IFNA2, ICAM1, IL1R1, IL8
23rantes459.9IL1R1, CHIA, CCL11, ICAM1, RNASE3
24pentoxifylline45 1110.9IL1R1, ICAM1, IL8, SELP
25cetirizine45 29 11 2412.9IL5, RNASE3, ICAM1, CCL11, IL8
26clarithromycin45 1110.9CCL11, IL5, IL8
27montelukast45 50 29 1112.8RNASE3, CCL11, IL5, LTC4S, IL8
28il-12459.8IL5, IL1R1, IL8
29methacholine45 1110.8IL8, IL5, RNASE3, ICAM1, CCL11
30hyaluronic acid45 2410.8RNASE3, CCL11, IL8, ICAM1, IL1R1
31prednisolone45 29 1111.8CCL11, IFNA2, RNASE3, IL5, IL1R1
32dextran sulfate459.7LDLR, ICAM1, IL5, SELP
33n acetylcysteine459.6SELP, CCL11, IL8, RNASE3, ICAM1, IL1R1
34budesonide45 50 1111.6RNASE3, SELP, IL8, ICAM1, CCL11, IL5
35n-formylmethionyl-leucylphenylalanine459.6CCL11, SELP, IL8, IL5, RNASE3, ICAM1
36fmlp459.5IL8, SELP, RNASE3, ICAM1, CCL11, IL5
37aspirin45 50 29 2412.5RNASE3, CCL11, LTC4S, IL1R1, LDLR, SELP
38sb 20358045 6010.4ICAM1, IL5, IL1R1, IL8, CCL11
39leukotriene b445 60 2411.3IL1R1, SELP, CCL11, LTC4S, RNASE3, IL8
40heparin45 29 11 2412.3LDLR, CCL11, IL8, IL1R1, RNASE3, VLDLR
41indomethacin45 60 29 1112.3CCL11, IFNA2, IL5, LDLR, IL1R1
42genistein45 29 60 2 11 2414.3IL5, ICAM1, CCL11, IL8, SELP, LDLR
43histamine45 29 2411.2SELP, CCL11, IFNA2, IL8, IL5, ICAM1
44vegf459.1IL8, IL5, IL1R1, SELP, ICAM1, IFNA2
45cyclosporin a45 29 6011.0SELP, CCL11, LDLR, ICAM1, RNASE3, IL8
46retinoic acid45 249.9LDLR, IL5, RNASE3, ICAM1, SELP, CCL11
47pge2458.8LTC4S, CCL11, SELP, LDLR, IL8, IL1R1
48dexamethasone45 50 29 1111.8SELP, LDLR, CCL11, ICAM1, LTC4S, RNASE3
49lipid458.7LDLR, IL1R1, RNASE3, LTC4S, VLDLR, CHIA
50tyrosine458.2ICAM1, IFNA2, CCL11, VLDLR, SELP, IL1R1

GO Terms for genes affiliated with Common Cold

Sources:
16Gene Ontology
See all sources

Cellular components related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9IFNA2, ICAM1, CHIA, IL5, IL8, SELP
2extracellular regionGO:0055766.3KRTAP1-1, CCL11, IFNA2, SCGB1D4, SCGB1C1, AOAH

Biological processes related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3IL8, IL1R1, IL5, CHIA, CCL11
2inflammatory responseGO:0069548.2SELP, CCL11, IFNA2, AOAH, IL5, IL8

Molecular functions related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein receptor activityGO:00504110.0LDLR, VLDLR
2very-low-density lipoprotein particle receptor activityGO:0302299.7LDLR, VLDLR
3glycoprotein bindingGO:0019489.6LDLR, SELP, VLDLR

Products for genes affiliated with Common Cold

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Cold

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet