MCID: CMM005
MIFTS: 59

Common Cold malady

Respiratory diseases category

Summaries for Common Cold

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards: Common Cold, also known as acute viral rhinopharyngitis, is related to influenza and asthma. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Spinal Cord Injury and TGF-Beta Pathway. The drugs ascorbic acid and phenylpropanolamine hydrochloride and the compounds anti-histamine and unicap have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotype immune system.

Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC:3 Español: El resfriado común y la secreción nasal o moqueo

Wikipedia:63 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza,head cold, or simply a... more...

Aliases & Classifications for Common Cold

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

common cold 8 10 44 33 60
acute viral rhinopharyngitis 8
nasopharyngitis - acute 8
nasopharyngitis, acute 8
acute nasopharyngitis 8
rhino-sinusitis 8
acute rhinitis 8
head cold, nos 8
acute coryza 8


External Ids:

Disease Ontology8 DOID:10459
ICD9CM27 460
MeSH34 D003139
ICD1025 J00

Related Diseases for Common Cold

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Common Cold via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.7CCL11, LDLR
2asthma30.7IL5, RNASE3, LTC4S
3rhinitis30.5CCL11, ICAM1, RNASE3, IL5, IL8
4allergic rhinitis30.4CCL11, ICAM1, RNASE3, IL5, IL8
5otitis media30.2CCL11, MUC5B, RNASE3
6myocardial infarction29.9CCL11, SELP, LDLR
7bronchitis29.9CCL11, RNASE3, IL5, IL8
8melanoma29.9IL8, FLNC, ICAM1, IFNA2, CCL11
9viral infectious disease29.9CCL11, IFNA2, ICAM1, IL8, LDLR
10cystic fibrosis29.9FLNC, MUC5B, RNASE3, IL1R1, IL8
11eosinophilia29.9CCL11, IFNA2, FLNC, RNASE3, IL5, IL8
12nasopharyngitis10.3
13adenoiditis10.1
14nephrotic syndrome10.0CCL11
15pulmonary fibrosis10.0IL8
16malaria10.0ICAM1
17galactosemia10.0ICAM1
18conjunctivitis10.0RNASE3
19pemphigus vulgaris10.0CCL11
20myositis10.0ICAM1
21diabetic retinopathy10.0ICAM1
22respiratory failure10.0ICAM1
23liver cirrhosis10.0IFNA2
24dermatitis herpetiformis10.0CCL11
25hypertension10.0ICAM1
26meningitis10.0IL8
27graves' disease10.0ICAM1
28deficiency anemia10.0IFNA2
29hypersensitivity reaction type ii disease10.0ICAM1
30nephritis10.0IL1R1
31pulmonary disease, chronic obstructive10.0MUC5B
32bronchiolitis obliterans10.0IL8
33atopic dermatitis10.0RNASE3, CCL11
34aspergillosis10.0FLNC
35mastitis10.0IL8
36urticaria10.0RNASE3, LTC4S
37thromboembolism10.0SELP
38migraine10.0LDLR
39periodontitis10.0IL8
40hepatitis b10.0IFNA2
41lichen planus10.0ICAM1, IFNA2
42stroke, ischemic10.0SELP
43acute pancreatitis10.0IL8, IL1R1
44alcoholic hepatitis10.0IL8, ICAM1
45muckle-wells syndrome10.0IL1R1
46alopecia areata10.0ICAM1, IL1R1
47immunoglobulin a vasculitis10.0ICAM1, RNASE3
48adenocarcinoma10.0LDLR
49choroid cancer10.0KRTAP1-1, KRTAP1-3
50severe combined immunodeficiency10.0IL5

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Clinical Features for Common Cold

About this section

Drugs & Therapeutics for Common Cold

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Common Cold

About this section

Anatomical Context for Common Cold

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Common Cold:

32
Eye, Testes, T cells, Skin, Lung, Monocytes

Animal Models for Common Cold or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Common Cold:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2LDLR, SELP, IL8, IL1R1, IL5, LTC4S

Publications for Common Cold

About this section
Sources:
50PubMed
See all sources

Articles related to Common Cold:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
The common cold: potential for future prevention or cure. (24415465)
2014
2
Guidelines on common cold for traditional Chinese medicine based on pattern differentiation. (24187858)
2013
3
The efficacy and safety of Baoji Tablets for treating common cold with summer-heat and dampness syndrome: study protocol for a randomized controlled trial. (24359521)
2013
4
Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. (22566526)
2012
5
An investigation of the effects of the common cold on simulated driving performance and detection of collisions: a laboratory study. (22761287)
2012
6
Cure for the common cold. (23013072)
2012
7
The first common cold sore susceptibility gene. (22039567)
2011
8
Placebo effects and the common cold: a randomized controlled trial. (21747102)
2011
9
May nasal hyperreactivity be a sequela of recurrent common cold? (21880220)
2011
10
The common cold and decongestant therapy. (21285300)
2011
11
The effect of vitamin C on the common cold. (21712220)
2011
12
Heated, humidified air for the common cold. (21563130)
2011
13
Effects of So-cheong-ryong-tang and Yeon-gyo-pae-dok-san on the common cold: randomized, double blind, placebo controlled trial. (21040773)
2011
14
Intranasal ipratropium bromide for the common cold. (21735425)
2011
15
Antibiotics for the common cold: expectations of Germany's general population. (20822733)
2010
16
Summaries for patients. Echinacea for the common cold. (21173397)
2010
17
Vitamin C for the common cold should not be rejected on the basis of old and erroneous articles. (19660806)
2009
18
Echinacea for prevention of the common cold: an illustrative overview of how information from different systematic reviews is summarised on the internet. (19389422)
2009
19
Sleep habits and susceptibility to the common cold. (19139325)
2009
20
The common cold. (19391294)
2009
21
The nasal decongestant effect of xylometazoline in the common cold. (18655753)
2008
22
James Angus Doull and the well-controlled common cold. (18840869)
2008
23
Sufficiently important difference for common cold: severity reduction. (17548849)
2007
24
Effect of vitamin C on common cold: randomized controlled trial. (16118650)
2006
25
Association of leukocyte activation, but not the common cold, with restenosis after percutaneous coronary intervention in patients with angina pectoris. (16293980)
2005
26
Review: a single dose of nasal decongestant reduces congestion in the short term in adults with the common cold; insufficient evidence exists on the effectiveness of repeated doses. (15688486)
2005
27
Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial. (16054520)
2005
28
Major degradation product identified in several pharmaceutical formulations against the common cold. (15649042)
2005
29
A multicultural approach to the patient who has a common cold. (15863627)
2005
30
Survey of parenting books for advice on the common cold, diarrhea, and otitis media in infants and toddlers. (15378153)
2004
31
Current and future therapeutic approaches to the common cold. (15482159)
2003
32
Antihistamines for the common cold. (12917904)
2003
33
Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. (12509647)
2003
34
Evaluation of the efficacy of a combined formulation (Grippostad-C) in the therapy of symptoms of common cold: a randomized, double-blind, multicenter trial. (12665160)
2003
35
FDA panel rejects common cold treatment. (12062983)
2002
36
Antibiotics for the common cold. (12137610)
2002
37
Effects of rhinovirus-induced common colds on granulocyte activity in allergic rhinitis. (12423609)
2002
38
Natural alternatives for the common cold: hype or hope? (11280018)
2001
39
Hydrogen peroxide in breath condensate during a common cold. (11817678)
2001
40
Herbs and the common cold. (11761519)
2000
41
Common cold. Zinc update. (11114798)
2000
42
The common cold at the turn of the millennium. (11068660)
2000
43
Efficacy and safety of a fixed combination phytomedicine in the treatment of the common cold (acute viral respiratory tract infection): results of a randomised, double blind, placebo controlled, multicentre study. (10621929)
1999
44
Allergen challenge-induced acute exudation of IL-8, ECP and alpha2-macroglobulin in human rhinovirus-induced common colds. (10836321)
1999
45
Another look at a meta-analysis of zinc salts lozenges and the common cold. (9616109)
1998
46
Types of stressors that increase susceptibility to the common cold in healthy adults. (9619470)
1998
47
Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children? (9063425)
1997
48
Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. (23195187)
1997
49
The common cold. Cold water on hot news. (8151858)
1994
50
Association of the common cold in the first trimester of pregnancy with birth defects. (8414827)
1993

Genetic Variations for Common Cold

About this section

Expression for genes affiliated with Common Cold

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Common Cold

Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

About this section
Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
See all sources

Pathways related to Common Cold according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL1R1, ICAM1
2
Hide members
10.0IL5, CCL11
3
Hide members
10.0IL5, CCL11
49.9ICAM1, IL1R1, IL8
59.8IFNA2, IL5, IL8
69.8CCL11, IL5, IL8
79.8ICAM1, IL5, IL8
89.7CCL11, IL5, SELP
9
Hide members
9.6IL1R1, IL5, ICAM1, IFNA2
10
Hide members
9.4IL5, RNASE3, ICAM1, IFNA2, CCL11
11
Hide members
9.1PLA2G2E, IL5, ICAM1, IFNA2, CCL11
12
Hide members
8.8CCL11, FLNC, IL5, IL1R1, IL8, PLA2G2E

Compounds for genes affiliated with Common Cold

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Common Cold according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1anti-histamine4410.3CCL11, ICAM1, RNASE3
2unicap4410.2CCL11, RNASE3, IL5
3loratadine44 11 2412.2ICAM1, RNASE3, IL8
4endotoxin4410.2ICAM1, AOAH, RNASE3
5levocabastine44 28 1112.1ICAM1, RNASE3, IL5
6roxithromycin44 28 1112.1CCL11, IL5, IL8
7sodium cromoglycate4410.0CCL11, ICAM1, RNASE3, IL5
8salmeterol44 49 28 1113.0CCL11, RNASE3, IL5, IL8
9lte44410.0CCL11, LTC4S, RNASE3, IL5
10ketotifen44 1111.0CCL11, ICAM1, RNASE3, IL5
11nedocromil sodium4410.0ICAM1, RNASE3, IL5, IL8
12pranlukast44 28 1112.0IL5, RNASE3, CCL11
13salbutamol44 49 28 11 2414.0CCL11, RNASE3, IL5, IL8
14ccl344 2811.0CCL11, ICAM1, IL1R1, IL8
15ltc44410.0IL5, RNASE3, LTC4S, CCL11
16fluticasone propionate44 49 59 1113.0IL8, IL5, RNASE3, CCL11
17azelastine44 1111.0ICAM1, RNASE3, IL5
18pgd2449.9IL5, RNASE3, LTC4S, CCL11
19sele449.9LDLR, SELP, ICAM1
20tarc449.9CCL11, ICAM1, IL5, IL8
21ltd4449.9IL5, RNASE3, LTC4S
22neopterin449.9IFNA2, ICAM1, IL1R1, IL8
23rantes449.9CCL11, ICAM1, CHIA, RNASE3, IL1R1
24pentoxifylline44 1110.9ICAM1, IL1R1, IL8, SELP
25cetirizine44 28 11 2412.9CCL11, ICAM1, RNASE3, IL5, IL8
26clarithromycin44 1110.9CCL11, IL5, IL8
27montelukast44 49 28 1112.8CCL11, LTC4S, RNASE3, IL5, IL8
28il-12449.8IL5, IL1R1, IL8
29methacholine44 1110.8CCL11, ICAM1, RNASE3, IL5, IL8
30hyaluronic acid44 2410.8IL8, IL1R1, RNASE3, ICAM1, CCL11
31prednisolone44 28 1111.8CCL11, IFNA2, RNASE3, IL5, IL1R1
32dextran sulfate449.7ICAM1, IL5, SELP, LDLR
33n acetylcysteine449.6SELP, IL8, IL1R1, RNASE3, ICAM1, CCL11
34budesonide44 49 1111.6SELP, IL8, IL5, RNASE3, ICAM1, CCL11
35n-formylmethionyl-leucylphenylalanine449.6CCL11, ICAM1, RNASE3, IL5, IL8, SELP
36fmlp449.5CCL11, ICAM1, RNASE3, IL5, IL8, SELP
37aspirin44 49 28 2412.5CCL11, LTC4S, RNASE3, IL1R1, SELP, LDLR
38sb 20358044 5910.4IL8, IL1R1, IL5, ICAM1, CCL11
39leukotriene b444 59 2411.3CCL11, LTC4S, RNASE3, IL5, IL1R1, IL8
40heparin44 28 11 2412.3CCL11, VLDLR, RNASE3, IL1R1, IL8, SELP
41indomethacin44 59 28 1112.3CCL11, IFNA2, IL5, IL1R1, LDLR
42genistein44 28 59 2 11 2414.3CCL11, ICAM1, IL5, IL8, SELP, LDLR
43histamine44 28 2411.2CCL11, IFNA2, ICAM1, LTC4S, RNASE3, IL5
44vegf449.1CCL11, IFNA2, ICAM1, RNASE3, IL5, IL1R1
45cyclosporin a44 28 5911.0CCL11, ICAM1, RNASE3, IL5, IL1R1, IL8
46retinoic acid44 249.9CCL11, IFNA2, ICAM1, RNASE3, IL5, IL1R1
47pge2448.8CCL11, ICAM1, LTC4S, RNASE3, IL5, IL1R1
48dexamethasone44 49 28 1111.8CCL11, ICAM1, LTC4S, RNASE3, IL5, IL1R1
49lipid448.7CCL11, IFNA2, CHIA, VLDLR, LTC4S, RNASE3
50tyrosine448.2CCL11, IFNA2, ICAM1, VLDLR, LTC4S, RNASE3

GO Terms for genes affiliated with Common Cold

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9IFNA2, ICAM1, CHIA, IL5, IL8, SELP
2extracellular regionGO:0055766.3KRTAP1-1, CCL11, IFNA2, SCGB1D4, SCGB1C1, AOAH

Biological processes related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3IL8, IL1R1, IL5, CHIA, CCL11
2inflammatory responseGO:0069548.2SELP, CCL11, IFNA2, AOAH, IL5, IL8

Molecular functions related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein receptor activityGO:00504110.0LDLR, VLDLR
2very-low-density lipoprotein particle receptor activityGO:0302299.7LDLR, VLDLR
3glycoprotein bindingGO:0019489.6LDLR, SELP, VLDLR

Products for genes affiliated with Common Cold

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Cold

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet