MCID: CMM005
MIFTS: 54

Common Cold malady

Respiratory diseases, Cancer diseases categories

Aliases & Classifications for Common Cold

About this section

Common Cold, Aliases & Descriptions:

Name: Common Cold 9 11 43 32 3 60
Acute Viral Rhinopharyngitis 9
Nasopharyngitis - Acute 9
Nasopharyngitis, Acute 9
 
Acute Nasopharyngitis 9
Rhino-Sinusitis 9
Acute Rhinitis 9
Acute Coryza 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:10459
ICD9CM27 460
MeSH33 D003139
ICD1025 J00

Summaries for Common Cold

About this section


MedlinePlus:32 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards based summary: Common Cold, also known as acute viral rhinopharyngitis, is related to sinusitis and asthma. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine Network and TSLP Signaling Pathway. The drugs pseudoephedrine and pseudoephedrine hydrochloride and the compounds anti-histamine and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are vision/eye and hematopoietic system.

Disease Ontology:9 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

Wikipedia:63 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza,head cold, or simply a... more...

Related Diseases for Common Cold

About this section

Diseases related to Common Cold via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1sinusitis31.3RNASE3, CCL11
2asthma31.0RNASE3, ICAM1, CCL11, IL8
3otitis media30.9CCL11, RNASE3
4allergic rhinitis30.7RNASE3, ICAM1, CCL11, IL8
5bronchitis30.7RNASE3, CCL11, IL8
6rhinitis30.5RNASE3, ICAM1, CCL11, IL8, ALB
7eosinophilia30.3RNASE3, CCL11, IFNA2, IL8
8cystic fibrosis29.9ALB, IL8, IL1R1, RNASE3
9viral infectious disease29.8LDLR, ICAM1, CCL11, IFNA2, IL8
10myocardial infarction29.7SELP, LDLR, CCL11
11blindness10.8
12eosinophilic gastroenteritis10.5CCL11
13conjunctivitis10.5RNASE3
14polyarteritis nodosa10.5IFNA2
15bronchiolitis obliterans10.5IL8
16influenza10.5
17muckle-wells syndrome10.4IL1R1
18chronic eosinophilic pneumonia10.4RNASE3, CCL11
19giant papillary conjunctivitis10.4RNASE3, CCL11
20atopy10.4RNASE3, CCL11
21allergic conjunctivitis10.4RNASE3, CCL11
22keratoconjunctivitis10.4RNASE3, CCL11
23eosinophilic pneumonia10.4RNASE3, CCL11
24food allergy10.4RNASE3, CCL11
25henoch-schoenlein purpura10.4ICAM1, RNASE3
26alcoholic hepatitis10.4ICAM1, IL8
27hypereosinophilic syndrome10.4CCL11, RNASE3
28bronchopulmonary dysplasia10.4RNASE3, IL8
29nasopharyngitis10.4
30bronchiectasis10.3RNASE3, IL8
31lichen planus10.3ICAM1, IFNA2
32respiratory failure10.3RNASE3, CCL11
33bronchiolitis10.3RNASE3, CCL11, IL8
34behcet's disease10.3IFNA2, IL8
35pulmonary eosinophilia10.3IL8, CCL11, RNASE3
36skin disease10.3ALB
37bacterial vaginosis10.3IL1R1, IL8
38alopecia areata10.3ICAM1, IL1R1
39bullous pemphigoid10.3RNASE3, CCL11
40chorioamnionitis10.3IL1R1, IL8
41pneumonia10.3ICAM1, CCL11, IL8
42pulmonary disease, chronic obstructive10.3IL8, CCL11, RNASE3
43arteriosclerosis10.3ICAM1, LDLR
44mastitis10.2ALB, IL8
45cork-handlers' disease10.2RNASE3, CCL11, IL8
46alcoholic liver cirrhosis10.2ALB, IL8
47ulcerative colitis10.2ALB
48interstitial lung disease10.2CCL11, IL1R1, IL8
49adenoiditis10.2
50adenoid hypertrophy10.2

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Symptoms for Common Cold

About this section

Drugs & Therapeutics for Common Cold

About this section

Genetic Tests for Common Cold

About this section

Anatomical Context for Common Cold

About this section

MalaCards organs/tissues related to Common Cold:

31
Eye, Testes, T cells, Lung, Skin, Monocytes

Animal Models for Common Cold or affiliated genes

About this section

MGI Mouse Phenotypes related to Common Cold:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4IL1R1, ICAM1, LDLR, SELP, VLDLR
2MP:00053978.0SELP, LDLR, ICAM1, CCL11, IL1R1, IL8
3MP:00053877.8SELP, LDLR, ICAM1, CCL11, IL1R1, IL8
4MP:00053847.7ALB, IL1R1, ICAM1, LDLR, SELP, VLDLR

Publications for Common Cold

About this section

Articles related to Common Cold:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
The common cold: potential for future prevention or cure. (24415465)
2014
2
Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials. (25411637)
2014
3
Intranasal ipratropium bromide for the common cold. (23784858)
2013
4
Associations between mental disorders and the common cold in adults: a population-based cross-sectional study. (23272991)
2013
5
Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle. (24277846)
2013
6
A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school children. (23930726)
2013
7
Complementary treatment of the common cold and flu with medicinal plants--results from two samples of pharmacy customers in Estonia. (23484045)
2013
8
Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. (22566526)
2012
9
Not curing the common cold. (23034853)
2012
10
Zinc for the common cold. (21328251)
2011
11
North American (Panax quinquefolius) and Asian Ginseng (Panax ginseng) Preparations for Prevention of the Common Cold in Healthy Adults: A Systematic Review. (19592479)
2011
12
Antibiotics for the common cold: expectations of Germany's general population. (20822733)
2010
13
Non-steroidal anti-inflammatory drugs for the common cold. (19588387)
2009
14
Is intranasal zinc effective and safe for the common cold? A systematic review and meta-analysis. (20690364)
2009
15
Do Japanese style acupuncture and moxibustion reduce symptoms of the common cold? (18955215)
2008
16
Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold. (18832713)
2008
17
Treatment of the common cold. (17323712)
2007
18
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
19
Echinacea for preventing and treating the common cold. (16437427)
2006
20
Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. (16844267)
2006
21
Antibiotic prescribing for children with nasopharyngitis (common colds), upper respiratory infections, and bronchitis who have health-professional parents. (16199689)
2005
22
Echinacea, vitamin C, the common cold, and blinding. (16080106)
2005
23
Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common cold. (15673581)
2005
24
Is there a common cold constitution? (12135399)
2002
25
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
26
Complementary and alternative therapies for the common cold. (11174218)
2001
27
Natural alternatives for the common cold: hype or hope? (11280018)
2001
28
Antivirals for the common cold. (11687023)
2001
29
Capillary electrophoresis with postcolumn infectivity assay for the analysis of different serotypes of human rhinovirus (common cold virus). (10857634)
2000
30
Herbs and the common cold. (11761519)
2000
31
Antibiotics and the common cold. (11127363)
2000
32
Common cold. Zinc update. (11114798)
2000
33
The relationship between the frequency of the common cold and the activities of natural killer cells. (21432487)
2000
34
Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. (10589439)
1999
35
The role of the common cold in asthma. (10073322)
1999
36
The common cold. (9866136)
1998
37
Sinusitis in the common cold. (9768580)
1998
38
JAMA patient page: the common cold. (9643869)
1998
39
Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): relationship to symptoms of the common cold and studying behavior. (9494693)
1998
40
Zinc gluconate and the common cold. Review of randomized controlled trials. (9612589)
1998
41
Zinc gluconate lozenges for treating the common cold. (9882105)
1997
42
Changes in nasal nitric oxide concentration associated with symptoms of common cold and treatment with a topical nasal decongestant. (9288222)
1997
43
Cost and the common cold. (9005758)
1997
44
Common cold and high-dose ipratropium bromide: use of anticholinergic medication as an indicator of reflex-mediated hypersecretion. (9299652)
1997
45
Caffeine and the common cold. (9443519)
1997
46
Futility and the common cold. How requests for antibiotics can illuminate care at the end of life. (7874961)
1995
47
Asthma and the common cold: can viruses imitate worms? (8128395)
1994
48
CT scans and the common cold? (8190165)
1994
49
Dangers of common cold treatments in children. (7679769)
1993
50
Use of retail pharmacy for common cold preparations in urban Harare. (8181443)
1993

Variations for Common Cold

About this section

Expression for genes affiliated with Common Cold

About this section
Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

About this section

Pathways related to Common Cold according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL8, IFNA2
29.9CCL11, IL8
39.8IL8, ICAM1
49.8IL8, ICAM1
5
Show member pathways
9.5ICAM1, CCL11, IL8
6
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.5IFNA2, IL1R1, IL8
7
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.5IL8, IL1R1, CCL11
8
Show member pathways
9.5IL1R1, IFNA2, ICAM1
99.4IL8, IFNA2, LDLR
109.4ICAM1, IL1R1, IL8
119.3IL8, ICAM1, SELP
12
Show member pathways
9.3RNASE3, ICAM1, CCL11, IFNA2
13
Show member pathways
9.2CCL11, IFNA2, IL1R1, IL8
14
Show member pathways
9.2IL8, IL1R1, IFNA2, CCL11
15
Show member pathways
thioredoxin pathway36
9.1LDLR, ICAM1, ALB
168.9IL8, IL1R1, ICAM1, SELP

Compounds for genes affiliated with Common Cold

About this section

Compounds related to Common Cold according to GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1anti-histamine439.9ICAM1, CCL11, RNASE3
2sodium cromoglycate439.9RNASE3, CCL11, ICAM1
3nedocromil sodium439.9RNASE3, IL8, ICAM1
4salmeterol43 49 28 1212.9RNASE3, CCL11, IL8
5loratadine43 24 1211.9RNASE3, ICAM1, IL8
6ketotifen43 1210.8ICAM1, CCL11, RNASE3
7montelukast43 49 28 1212.8RNASE3, IL8, CCL11
8cetirizine43 28 24 1212.7ICAM1, IL8, CCL11, RNASE3
9methacholine43 49 1211.6ICAM1, RNASE3, IL8, CCL11
10neopterin439.5IFNA2, IL8, ICAM1, IL1R1
11ccl343 2810.5IL1R1, ICAM1, IL8, CCL11
12sele439.5SELP, ICAM1, LDLR
13groalpha439.4CCL11, ICAM1, IL8
14cuprophan439.4ICAM1, IL1R1, SELP
15polymyxin b439.4IL8, ICAM1, LDLR
16troglitazone43 28 59 1212.3IL8, CCL11, LDLR, ICAM1
17pentoxifylline43 1210.3IL8, IL1R1, ICAM1, SELP
18endotoxin439.2CCL11, ICAM1, IL1R1, IL8, RNASE3
19polyethylene glycol439.2ALB, IL1R1, IFNA2, ICAM1
20budesonide43 49 1211.2IL8, CCL11, ICAM1, RNASE3, SELP
21n-formylmethionyl-leucylphenylalanine439.1SELP, RNASE3, ICAM1, CCL11, IL8
22fmlp439.1ICAM1, CCL11, SELP, RNASE3, IL8
23leukotriene b443 59 2411.1SELP, CCL11, IL8, IL1R1, RNASE3
24prednisolone43 28 1211.0CCL11, IFNA2, IL1R1, RNASE3, ALB
25polysulfone439.0IL1R1, SELP, ALB
26mannitol43 1210.0IFNA2, ALB, SELP, ICAM1
27simvastatin43 49 59 28 24 1213.9SELP, LDLR, ICAM1, IL8
28actinomycin d438.9IL8, IL1R1, LDLR, ICAM1, CCL11
29dextran sulfate438.9LDLR, SELP, ALB, ICAM1
30aspirin43 49 28 2411.9LDLR, SELP, RNASE3, CCL11, IL1R1
31indomethacin43 28 59 1211.8CCL11, IFNA2, LDLR, IL1R1, ALB
32genistein43 28 59 2 24 1213.8ICAM1, SELP, LDLR, CCL11, IL8
33ascorbic acid43 249.7ICAM1, IL1R1, ALB, LDLR, IFNA2
34rantes438.7CCL11, ICAM1, RNASE3, IL8, IL1R1, SELP
35n acetylcysteine438.7IL8, IL1R1, SELP, CCL11, ICAM1, RNASE3
36hyaluronic acid43 249.6IL8, IL1R1, CCL11, ICAM1, RNASE3, ALB
37fibrinogen438.6RNASE3, ICAM1, IL1R1, ALB, SELP
38nitric oxide43 24 1210.5SELP, IL8, IL1R1, CCL11, ICAM1, RNASE3
39fatty acid438.5IFNA2, IL1R1, VLDLR, ALB, LDLR
40vegf438.4IL8, IL1R1, IFNA2, CCL11, SELP, RNASE3
41lactate438.4IL8, IL1R1, ALB, ICAM1, RNASE3, SELP
42retinoic acid43 249.3SELP, IFNA2, LDLR, ICAM1, IL1R1, RNASE3
43cyclosporin a43 28 5910.3ICAM1, SELP, IL8, IL1R1, CCL11, LDLR
44pge2438.3CCL11, IL1R1, IL8, LDLR, RNASE3, SELP
45histamine43 28 2410.3IL8, SELP, RNASE3, ICAM1, CCL11, IFNA2
46dexamethasone43 49 28 1211.3CCL11, IL1R1, IL8, ICAM1, LDLR, RNASE3
47lipid438.1CCL11, ALB, IL1R1, VLDLR, RNASE3, IFNA2
48creatinine437.9ALB, VLDLR, RNASE3, SELP, IL1R1
49cysteine437.9IL1R1, ALB, IFNA2, LDLR, SELP, IL8
50heparin43 28 24 1210.6ALB, VLDLR, SELP, RNASE3, LDLR, CCL11

GO Terms for genes affiliated with Common Cold

About this section

Cellular components related to Common Cold according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2ICAM1, LDLR, SELP
2extracellular spaceGO:00056157.8SELP, ICAM1, CCL11, IFNA2, IL8, ALB
3extracellular regionGO:00055766.8ALB, SCGB1C1, SCGB1D4, RNASE3, CCL11, IFNA2

Biological processes related to Common Cold according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:00713479.8ICAM1, IL8
2regulation of cell adhesionGO:00301559.8IL8, ICAM1
3positive regulation of actin filament polymerizationGO:00308389.7CCL11, ICAM1
4leukocyte cell-cell adhesionGO:00071599.7ICAM1, SELP
5heterophilic cell-cell adhesionGO:00071579.7ICAM1, SELP
6inflammatory responseGO:00069549.2IL8, IFNA2, CCL11, SELP
7lipoprotein metabolic processGO:00421579.1ALB, LDLR

Molecular functions related to Common Cold according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor activityGO:00302299.6LDLR, VLDLR
2calcium-dependent protein bindingGO:00483069.6SELP, VLDLR
3low-density lipoprotein receptor activityGO:00050419.3LDLR, VLDLR
4glycoprotein bindingGO:00019489.2LDLR, SELP, VLDLR
5protein bindingGO:00055156.8VLDLR, SELP, LDLR, ICAM1, CCL11, IFNA2

Products for genes affiliated with Common Cold

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Common Cold

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet