MCID: CMM005
MIFTS: 59

Common Cold malady

Respiratory diseases category

Summaries for Common Cold

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards: Common Cold, also known as acute viral rhinopharyngitis, is related to influenza and asthma. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Spinal Cord Injury and TGF-Beta Pathway. The drugs ascorbic acid and phenylpropanolamine hydrochloride and the compounds anti-histamine and unicap have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotype immune system.

Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC:3 Español: El resfriado común y la secreción nasal o moqueo

Wikipedia:63 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza,head cold, or simply a... more...

Aliases & Classifications for Common Cold

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

common cold 8 10 44 33 60
acute viral rhinopharyngitis 8
nasopharyngitis - acute 8
nasopharyngitis, acute 8
acute nasopharyngitis 8
rhino-sinusitis 8
acute rhinitis 8
head cold, nos 8
acute coryza 8


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Disease Ontology8 DOID:10459
ICD9CM27 460
MeSH34 D003139
ICD1025 J00

Related Diseases for Common Cold

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Common Cold via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.7CCL11, LDLR
2asthma30.7IL5, RNASE3, LTC4S
3rhinitis30.5CCL11, ICAM1, RNASE3, IL5, IL8
4allergic rhinitis30.4CCL11, ICAM1, RNASE3, IL5, IL8
5otitis media30.2CCL11, MUC5B, RNASE3
6myocardial infarction29.9CCL11, SELP, LDLR
7bronchitis29.9CCL11, RNASE3, IL5, IL8
8melanoma29.9IL8, FLNC, ICAM1, IFNA2, CCL11
9viral infectious disease29.9CCL11, IFNA2, ICAM1, IL8, LDLR
10cystic fibrosis29.9FLNC, MUC5B, RNASE3, IL1R1, IL8
11eosinophilia29.9CCL11, IFNA2, FLNC, RNASE3, IL5, IL8
12nasopharyngitis10.3
13adenoiditis10.1
14nephrotic syndrome10.0CCL11
15pulmonary fibrosis10.0IL8
16malaria10.0ICAM1
17galactosemia10.0ICAM1
18conjunctivitis10.0RNASE3
19pemphigus vulgaris10.0CCL11
20myositis10.0ICAM1
21diabetic retinopathy10.0ICAM1
22respiratory failure10.0ICAM1
23liver cirrhosis10.0IFNA2
24dermatitis herpetiformis10.0CCL11
25hypertension10.0ICAM1
26meningitis10.0IL8
27graves' disease10.0ICAM1
28deficiency anemia10.0IFNA2
29hypersensitivity reaction type ii disease10.0ICAM1
30nephritis10.0IL1R1
31pulmonary disease, chronic obstructive10.0MUC5B
32bronchiolitis obliterans10.0IL8
33atopic dermatitis10.0RNASE3, CCL11
34aspergillosis10.0FLNC
35mastitis10.0IL8
36urticaria10.0RNASE3, LTC4S
37thromboembolism10.0SELP
38migraine10.0LDLR
39periodontitis10.0IL8
40hepatitis b10.0IFNA2
41lichen planus10.0ICAM1, IFNA2
42stroke, ischemic10.0SELP
43acute pancreatitis10.0IL8, IL1R1
44alcoholic hepatitis10.0IL8, ICAM1
45muckle-wells syndrome10.0IL1R1
46alopecia areata10.0ICAM1, IL1R1
47immunoglobulin a vasculitis10.0ICAM1, RNASE3
48adenocarcinoma10.0LDLR
49choroid cancer10.0KRTAP1-1, KRTAP1-3
50severe combined immunodeficiency10.0IL5

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Clinical Features for Common Cold

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Drugs & Therapeutics for Common Cold

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Common Cold

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Anatomical Context for Common Cold

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Sources:
32MalaCards
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MalaCards organs/tissues related to Common Cold:

32
Eye, Testes, T cells, Lung, Skin, Monocytes

Animal Models for Common Cold or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Common Cold:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2LDLR, SELP, IL8, IL1R1, IL5, LTC4S

Publications for Common Cold

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Sources:
50PubMed
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Articles related to Common Cold:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Viral uncoating is directional: exit of the genomic RNA in a common cold virus starts with the poly-(A) tail at the 3'-end. (23592991)
2013
2
Can probiotics prevent or improve common cold and influenza? (23306139)
2013
3
Antibiotics for the common cold and acute purulent rhinitis. (23733381)
2013
4
Not curing the common cold. (23034853)
2012
5
A combination of high-dose vitamin C plus zinc for the common cold. (22429343)
2012
6
Treatment of the common cold in children and adults. (22962927)
2012
7
A prospective study of work stressors and the common cold. (20833997)
2011
8
Non-antibiotic treatment for pediatric outpatients with common cold inhibits the emergence of drug resistant pneumococci. (21485653)
2010
9
The common cold and concurrent otitis media. (19687412)
2009
10
Garlic for the common cold. (19588383)
2009
11
Immunological evidence supporting the use of extracts from Boehmeria jamaicensis Urb for treating the common cold and sinus infections. (18646490)
2007
12
Inflammatory changes during the 'common cold' are associated with platelet activation and increased reactivity of platelets to agonists. (17982310)
2007
13
Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. (17474541)
2007
14
Nasal inflammation induced by a common cold: comparison between controls and patients with nasal polyposis under topical steroid therapy. (17608135)
2007
15
Vitamin C for preventing and treating the common cold. (17636648)
2007
16
Common cold. (17934038)
2007
17
Chinese medicinal herbs for the common cold. (17253524)
2007
18
Population-based case-control study of the common cold during pregnancy and congenital abnormalities. (16450209)
2006
19
Pregnancy complications and delivery outcomes of pregnant women with common cold. (16705874)
2006
20
The effect of vitamin E on common cold incidence is modified by age, smoking and residential neighborhood. (16943455)
2006
21
The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children. (16982486)
2006
22
Nasal cytokines as mediators of illness during the common cold. (15842953)
2005
23
Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. (14748902)
2004
24
Potential neurovirulence of common cold virus. (15555652)
2004
25
Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial. (15197051)
2004
26
Treatment of the common cold with unrefined echinacea. A randomized, double-blind, placebo-controlled trial. (12484708)
2002
27
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
28
Antivirals for the common cold. (11687023)
2001
29
Consumers' self-care algorithms for the common cold: implications for health education interventions. (11534748)
2001
30
Complexes between monoclonal antibodies and receptor fragments with a common cold virus: determination of stoichiometry by capillary electrophoresis. (11534714)
2001
31
Echinacea vs. the common cold. (10637028)
2000
32
A review on recent development of common cold therapeutic agents. (11354808)
2000
33
Antibiotics for the common cold. (10796517)
2000
34
Zinc lozenges for the common cold. (9926628)
1999
35
The common cold and asthma. (10565492)
1999
36
Recognizing and treating common cold-induced injury in outdoor sports. (10527306)
1999
37
JAMA patient page: the common cold. (9643869)
1998
38
Home-based therapies for the common cold among European American and ethnic minority families: the interface between alternative/complementary and folk medicine. (9811285)
1998
39
Antihistaminic-decongestant combination in common cold. (9707917)
1998
40
The role of zinc lozenges in treatment of the common cold. (9475824)
1998
41
Characterization of the T cell response to human rhinovirus in children: implications for understanding the immunopathology of the common cold. (9291326)
1997
42
Antibiotics for the common cold. (8806311)
1996
43
Sport, exercise, and the common cold. (16558389)
1996
44
Futility and the common cold. How requests for antibiotics can illuminate care at the end of life. (7874961)
1995
45
Complete sequence of the RNA genome of human rhinovirus 16, a clinically useful common cold virus belonging to the ICAM-1 receptor group. (7732663)
1995
46
Asthma and the common cold: can viruses imitate worms? (8128395)
1994
47
Literature review: the common cold. (7988393)
1994
48
Microvascular exudative hyperresponsiveness in human coronavirus-induced common cold. (8128400)
1994
49
Gender differences in the perceptions of common cold symptoms. (8424180)
1993
50
Cold agglutinin disease after chicken pox. An uncommon complication of a common disease. (1728870)
1992

Genetic Variations for Common Cold

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Expression for genes affiliated with Common Cold

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Common Cold

Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Common Cold according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL1R1, ICAM1
2
Hide members
10.0IL5, CCL11
3
Hide members
10.0IL5, CCL11
49.9ICAM1, IL1R1, IL8
59.8IFNA2, IL5, IL8
69.8CCL11, IL5, IL8
79.8ICAM1, IL5, IL8
89.7CCL11, IL5, SELP
9
Hide members
9.6IL1R1, IL5, ICAM1, IFNA2
10
Hide members
9.4IL5, RNASE3, ICAM1, IFNA2, CCL11
11
Hide members
9.1PLA2G2E, IL5, ICAM1, IFNA2, CCL11
12
Hide members
8.8CCL11, FLNC, IL5, IL1R1, IL8, PLA2G2E

Compounds for genes affiliated with Common Cold

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Common Cold according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1anti-histamine4410.3CCL11, ICAM1, RNASE3
2unicap4410.2RNASE3, IL5, CCL11
3loratadine44 11 2412.2ICAM1, RNASE3, IL8
4endotoxin4410.2ICAM1, AOAH, RNASE3
5levocabastine44 28 1112.1IL5, ICAM1, RNASE3
6roxithromycin44 28 1112.1IL8, CCL11, IL5
7sodium cromoglycate4410.0CCL11, IL5, ICAM1, RNASE3
8lte44410.0IL5, LTC4S, CCL11, RNASE3
9salmeterol44 49 28 1113.0IL8, RNASE3, CCL11, IL5
10ketotifen44 1111.0RNASE3, ICAM1, CCL11, IL5
11nedocromil sodium4410.0RNASE3, ICAM1, IL8, IL5
12pranlukast44 28 1112.0IL5, CCL11, RNASE3
13salbutamol44 49 28 11 2414.0RNASE3, CCL11, IL5, IL8
14ccl344 2811.0ICAM1, IL1R1, IL8, CCL11
15ltc44410.0RNASE3, LTC4S, CCL11, IL5
16fluticasone propionate44 49 59 1113.0CCL11, RNASE3, IL8, IL5
17azelastine44 1111.0ICAM1, RNASE3, IL5
18pgd2449.9IL5, RNASE3, LTC4S, CCL11
19sele449.9ICAM1, SELP, LDLR
20tarc449.9ICAM1, CCL11, IL8, IL5
21ltd4449.9IL5, LTC4S, RNASE3
22neopterin449.9IFNA2, ICAM1, IL1R1, IL8
23rantes449.9IL1R1, CHIA, CCL11, ICAM1, RNASE3
24pentoxifylline44 1110.9IL1R1, ICAM1, IL8, SELP
25cetirizine44 28 11 2412.9IL5, RNASE3, ICAM1, CCL11, IL8
26clarithromycin44 1110.9CCL11, IL5, IL8
27montelukast44 49 28 1112.8RNASE3, CCL11, IL5, LTC4S, IL8
28il-12449.8IL5, IL1R1, IL8
29methacholine44 1110.8IL8, IL5, RNASE3, ICAM1, CCL11
30hyaluronic acid44 2410.8RNASE3, CCL11, IL8, ICAM1, IL1R1
31prednisolone44 28 1111.8CCL11, IFNA2, RNASE3, IL5, IL1R1
32dextran sulfate449.7LDLR, ICAM1, IL5, SELP
33n acetylcysteine449.6SELP, CCL11, IL8, RNASE3, ICAM1, IL1R1
34budesonide44 49 1111.6RNASE3, SELP, IL8, ICAM1, CCL11, IL5
35n-formylmethionyl-leucylphenylalanine449.6CCL11, SELP, IL8, IL5, RNASE3, ICAM1
36fmlp449.5IL8, SELP, RNASE3, ICAM1, CCL11, IL5
37aspirin44 49 28 2412.5RNASE3, CCL11, LTC4S, IL1R1, LDLR, SELP
38sb 20358044 5910.4ICAM1, IL5, IL1R1, IL8, CCL11
39leukotriene b444 59 2411.3IL1R1, SELP, CCL11, LTC4S, RNASE3, IL8
40heparin44 28 11 2412.3LDLR, CCL11, IL8, IL1R1, RNASE3, VLDLR
41indomethacin44 59 28 1112.3CCL11, IFNA2, IL5, LDLR, IL1R1
42genistein44 28 59 2 11 2414.3IL5, ICAM1, CCL11, IL8, SELP, LDLR
43histamine44 28 2411.2SELP, CCL11, IFNA2, IL8, IL5, ICAM1
44vegf449.1IL8, IL5, IL1R1, SELP, ICAM1, IFNA2
45cyclosporin a44 28 5911.0SELP, CCL11, LDLR, ICAM1, RNASE3, IL8
46retinoic acid44 249.9LDLR, IL5, RNASE3, ICAM1, SELP, CCL11
47pge2448.8LTC4S, CCL11, SELP, LDLR, IL8, IL1R1
48dexamethasone44 49 28 1111.8SELP, LDLR, CCL11, ICAM1, LTC4S, RNASE3
49lipid448.7LDLR, IL1R1, RNASE3, LTC4S, VLDLR, CHIA
50tyrosine448.2ICAM1, IFNA2, CCL11, VLDLR, SELP, IL1R1

GO Terms for genes affiliated with Common Cold

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16Gene Ontology
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Cellular components related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9IFNA2, ICAM1, CHIA, IL5, IL8, SELP
2extracellular regionGO:0055766.3KRTAP1-1, CCL11, IFNA2, SCGB1D4, SCGB1C1, AOAH

Biological processes related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3IL8, IL1R1, IL5, CHIA, CCL11
2inflammatory responseGO:0069548.2SELP, CCL11, IFNA2, AOAH, IL5, IL8

Molecular functions related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein receptor activityGO:00504110.0LDLR, VLDLR
2very-low-density lipoprotein particle receptor activityGO:0302299.7LDLR, VLDLR
3glycoprotein bindingGO:0019489.6LDLR, SELP, VLDLR

Products for genes affiliated with Common Cold

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Cold

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet