MCID: CMM005
MIFTS: 64

Common Cold malady

Respiratory diseases, Cancer diseases categories

Summaries for Common Cold

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MedlinePlus:34 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards based summary: Common Cold, also known as acute nasopharyngitis, is related to asthma and sinusitis. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine Network and TSLP Signaling Pathway. The drugs ascorbic acid and phenylpropanolamine hydrochloride and the compounds anti-histamine and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are vision/eye and hematopoietic system.

Disease Ontology:10 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

Wikipedia:65 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza,head cold, or simply a... more...

Aliases & Classifications for Common Cold

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 34MedlinePlus, 4CDC, 62UMLS, 29ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD10
See all sources

Common Cold, Aliases & Descriptions:

Name: Common Cold 10 12 45 34 4 62
Acute Nasopharyngitis 10 62
Acute Rhinitis 10 62
Acute Coryza 10 62
 
Acute Viral Rhinopharyngitis 10
Nasopharyngitis - Acute 10
Nasopharyngitis, Acute 10
Rhino-Sinusitis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology10 DOID:10459
ICD9CM29 460
MeSH35 D003139
ICD1027 J00

Related Diseases for Common Cold

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Diseases related to Common Cold via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1asthma30.8ICAM1, CCL11, IL8, RNASE3
2sinusitis30.7RNASE3, CCL11
3rhinitis30.6ALB, ICAM1, IL8, CCL11, RNASE3
4allergic rhinitis30.5IL8, CCL11, ICAM1, RNASE3
5otitis media30.4RNASE3, CCL11
6bronchitis30.3CCL11, RNASE3, IL8
7eosinophilia30.0IFNA2, IL8, CCL11, RNASE3
8cystic fibrosis30.0RNASE3, IL8, IL1R1, ALB
9viral infectious disease30.0LDLR, IFNA2, ICAM1, CCL11, IL8
10myocardial infarction30.0CCL11, LDLR, SELP
11blindness10.8
12influenza10.5
13nasopharyngitis10.4
14adenoiditis10.2
15adenoid hypertrophy10.2
16eosinophilic gastroenteritis10.1CCL11
17conjunctivitis10.1RNASE3
18polyarteritis nodosa10.1IFNA2
19bronchiolitis obliterans10.1IL8
20muckle-wells syndrome10.0IL1R1
21chronic eosinophilic pneumonia10.0RNASE3, CCL11
22giant papillary conjunctivitis10.0CCL11, RNASE3
23atopy10.0RNASE3, CCL11
24allergic conjunctivitis10.0RNASE3, CCL11
25keratoconjunctivitis10.0RNASE3, CCL11
26eosinophilic pneumonia10.0CCL11, RNASE3
27food allergy10.0RNASE3, CCL11
28henoch-schoenlein purpura10.0RNASE3, ICAM1
29alcoholic hepatitis10.0ICAM1, IL8
30hypereosinophilic syndrome10.0RNASE3, CCL11
31bronchopulmonary dysplasia10.0RNASE3, IL8
32bronchiectasis10.0RNASE3, IL8
33lichen planus10.0IFNA2, ICAM1
34respiratory failure10.0RNASE3, CCL11
35bronchiolitis10.0RNASE3, IL8, CCL11
36behcet's disease10.0IL8, IFNA2
37pulmonary eosinophilia10.0IL8, RNASE3, CCL11
38skin disease10.0ALB
39bacterial vaginosis10.0IL1R1, IL8
40alopecia areata10.0IL1R1, ICAM1
41bullous pemphigoid10.0RNASE3, CCL11
42chorioamnionitis10.0IL8, IL1R1
43pneumonia10.0CCL11, IL8, ICAM1
44pulmonary disease, chronic obstructive10.0CCL11, IL8, RNASE3
45tonsillitis10.0
46otosalpingitis10.0
47arteriosclerosis10.0LDLR, ICAM1
48mastitis10.0IL8, ALB
49cork-handlers' disease10.0CCL11, IL8, RNASE3
50alcoholic liver cirrhosis10.0ALB, IL8

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Symptoms for Common Cold

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Drugs & Therapeutics for Common Cold

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Genetic Tests for Common Cold

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Anatomical Context for Common Cold

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MalaCards organs/tissues related to Common Cold:

33
Eye, Testes, T cells, Lung, Skin, Monocytes

Animal Models for Common Cold or affiliated genes

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MGI Mouse Phenotypes related to Common Cold:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4IL1R1, ICAM1, LDLR, SELP, VLDLR
2MP:00053978.0SELP, LDLR, ICAM1, CCL11, IL1R1, IL8
3MP:00053877.8SELP, LDLR, ICAM1, CCL11, IL1R1, IL8
4MP:00053847.7ALB, IL1R1, ICAM1, LDLR, SELP, VLDLR

Publications for Common Cold

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Articles related to Common Cold:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
The common cold: potential for future prevention or cure. (24415465)
2014
2
Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials. (25411637)
2014
3
Intranasal ipratropium bromide for the common cold. (23784858)
2013
4
Associations between mental disorders and the common cold in adults: a population-based cross-sectional study. (23272991)
2013
5
Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle. (24277846)
2013
6
A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school children. (23930726)
2013
7
Complementary treatment of the common cold and flu with medicinal plants--results from two samples of pharmacy customers in Estonia. (23484045)
2013
8
Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. (22566526)
2012
9
Not curing the common cold. (23034853)
2012
10
Zinc for the common cold. (21328251)
2011
11
North American (Panax quinquefolius) and Asian Ginseng (Panax ginseng) Preparations for Prevention of the Common Cold in Healthy Adults: A Systematic Review. (19592479)
2011
12
Antibiotics for the common cold: expectations of Germany's general population. (20822733)
2010
13
Non-steroidal anti-inflammatory drugs for the common cold. (19588387)
2009
14
Is intranasal zinc effective and safe for the common cold? A systematic review and meta-analysis. (20690364)
2009
15
Do Japanese style acupuncture and moxibustion reduce symptoms of the common cold? (18955215)
2008
16
Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold. (18832713)
2008
17
Treatment of the common cold. (17323712)
2007
18
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
19
Echinacea for preventing and treating the common cold. (16437427)
2006
20
Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. (16844267)
2006
21
Antibiotic prescribing for children with nasopharyngitis (common colds), upper respiratory infections, and bronchitis who have health-professional parents. (16199689)
2005
22
Echinacea, vitamin C, the common cold, and blinding. (16080106)
2005
23
Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common cold. (15673581)
2005
24
Is there a common cold constitution? (12135399)
2002
25
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
26
Complementary and alternative therapies for the common cold. (11174218)
2001
27
Natural alternatives for the common cold: hype or hope? (11280018)
2001
28
Antivirals for the common cold. (11687023)
2001
29
Capillary electrophoresis with postcolumn infectivity assay for the analysis of different serotypes of human rhinovirus (common cold virus). (10857634)
2000
30
Herbs and the common cold. (11761519)
2000
31
Antibiotics and the common cold. (11127363)
2000
32
Common cold. Zinc update. (11114798)
2000
33
The relationship between the frequency of the common cold and the activities of natural killer cells. (21432487)
2000
34
Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. (10589439)
1999
35
The role of the common cold in asthma. (10073322)
1999
36
The common cold. (9866136)
1998
37
Sinusitis in the common cold. (9768580)
1998
38
JAMA patient page: the common cold. (9643869)
1998
39
Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): relationship to symptoms of the common cold and studying behavior. (9494693)
1998
40
Zinc gluconate and the common cold. Review of randomized controlled trials. (9612589)
1998
41
Zinc gluconate lozenges for treating the common cold. (9882105)
1997
42
Changes in nasal nitric oxide concentration associated with symptoms of common cold and treatment with a topical nasal decongestant. (9288222)
1997
43
Cost and the common cold. (9005758)
1997
44
Common cold and high-dose ipratropium bromide: use of anticholinergic medication as an indicator of reflex-mediated hypersecretion. (9299652)
1997
45
Caffeine and the common cold. (9443519)
1997
46
Futility and the common cold. How requests for antibiotics can illuminate care at the end of life. (7874961)
1995
47
Asthma and the common cold: can viruses imitate worms? (8128395)
1994
48
CT scans and the common cold? (8190165)
1994
49
Dangers of common cold treatments in children. (7679769)
1993
50
Use of retail pharmacy for common cold preparations in urban Harare. (8181443)
1993

Variations for Common Cold

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Expression for genes affiliated with Common Cold

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Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

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Pathways related to Common Cold according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL8, IFNA2
29.9CCL11, IL8
39.8IL8, ICAM1
49.8IL8, ICAM1
5
Show member pathways
9.5ICAM1, CCL11, IL8
6
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5IFNA2, IL1R1, IL8
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5IL8, IL1R1, CCL11
8
Show member pathways
9.5IL1R1, IFNA2, ICAM1
99.4IL8, IFNA2, LDLR
109.4ICAM1, IL1R1, IL8
119.3IL8, ICAM1, SELP
12
Show member pathways
9.3RNASE3, ICAM1, CCL11, IFNA2
13
Show member pathways
9.2CCL11, IFNA2, IL1R1, IL8
14
Show member pathways
9.2IL8, IL1R1, IFNA2, CCL11
15
Show member pathways
thioredoxin pathway38
9.1LDLR, ICAM1, ALB
168.9IL8, IL1R1, ICAM1, SELP

Compounds for genes affiliated with Common Cold

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Compounds related to Common Cold according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1anti-histamine459.9ICAM1, CCL11, RNASE3
2sodium cromoglycate459.9RNASE3, CCL11, ICAM1
3nedocromil sodium459.9RNASE3, IL8, ICAM1
4salmeterol45 51 30 1312.9RNASE3, CCL11, IL8
5loratadine45 26 1311.9RNASE3, ICAM1, IL8
6ketotifen45 1310.8ICAM1, CCL11, RNASE3
7montelukast45 51 30 1312.8RNASE3, IL8, CCL11
8cetirizine45 30 26 1312.7ICAM1, IL8, CCL11, RNASE3
9methacholine45 51 1311.6ICAM1, RNASE3, IL8, CCL11
10neopterin459.5IFNA2, IL8, ICAM1, IL1R1
11ccl345 3010.5IL1R1, ICAM1, IL8, CCL11
12sele459.5SELP, ICAM1, LDLR
13groalpha459.4CCL11, ICAM1, IL8
14cuprophan459.4ICAM1, IL1R1, SELP
15polymyxin b459.4IL8, ICAM1, LDLR
16troglitazone45 30 61 1312.3IL8, CCL11, LDLR, ICAM1
17pentoxifylline45 1310.3IL8, IL1R1, ICAM1, SELP
18endotoxin459.2CCL11, ICAM1, IL1R1, IL8, RNASE3
19polyethylene glycol459.2ALB, IL1R1, IFNA2, ICAM1
20budesonide45 51 1311.2IL8, CCL11, ICAM1, RNASE3, SELP
21n-formylmethionyl-leucylphenylalanine459.1SELP, RNASE3, ICAM1, CCL11, IL8
22fmlp459.1ICAM1, CCL11, SELP, RNASE3, IL8
23leukotriene b445 61 2611.1SELP, CCL11, IL8, IL1R1, RNASE3
24prednisolone45 30 1311.0CCL11, IFNA2, IL1R1, RNASE3, ALB
25polysulfone459.0IL1R1, SELP, ALB
26mannitol45 1310.0IFNA2, ALB, SELP, ICAM1
27simvastatin45 51 61 30 26 1313.9SELP, LDLR, ICAM1, IL8
28actinomycin d458.9IL8, IL1R1, LDLR, ICAM1, CCL11
29dextran sulfate458.9LDLR, SELP, ALB, ICAM1
30aspirin45 51 30 2611.9LDLR, SELP, RNASE3, CCL11, IL1R1
31indomethacin45 30 61 1311.8CCL11, IFNA2, LDLR, IL1R1, ALB
32genistein45 30 61 3 26 1313.8ICAM1, SELP, LDLR, CCL11, IL8
33ascorbic acid45 269.7ICAM1, IL1R1, ALB, LDLR, IFNA2
34rantes458.7CCL11, ICAM1, RNASE3, IL8, IL1R1, SELP
35n acetylcysteine458.7IL8, IL1R1, SELP, CCL11, ICAM1, RNASE3
36hyaluronic acid45 269.6IL8, IL1R1, CCL11, ICAM1, RNASE3, ALB
37fibrinogen458.6RNASE3, ICAM1, IL1R1, ALB, SELP
38nitric oxide45 26 1310.5SELP, IL8, IL1R1, CCL11, ICAM1, RNASE3
39fatty acid458.5IFNA2, IL1R1, VLDLR, ALB, LDLR
40vegf458.4IL8, IL1R1, IFNA2, CCL11, SELP, RNASE3
41lactate458.4IL8, IL1R1, ALB, ICAM1, RNASE3, SELP
42retinoic acid45 269.3SELP, IFNA2, LDLR, ICAM1, IL1R1, RNASE3
43cyclosporin a45 30 6110.3ICAM1, SELP, IL8, IL1R1, CCL11, LDLR
44pge2458.3CCL11, IL1R1, IL8, LDLR, RNASE3, SELP
45histamine45 30 2610.3IL8, SELP, RNASE3, ICAM1, CCL11, IFNA2
46dexamethasone45 51 30 1311.3CCL11, IL1R1, IL8, ICAM1, LDLR, RNASE3
47lipid458.1CCL11, ALB, IL1R1, VLDLR, RNASE3, IFNA2
48creatinine457.9ALB, VLDLR, RNASE3, SELP, IL1R1
49cysteine457.9IL1R1, ALB, IFNA2, LDLR, SELP, IL8
50heparin45 30 26 1310.6ALB, VLDLR, SELP, RNASE3, LDLR, CCL11

GO Terms for genes affiliated with Common Cold

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Cellular components related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2ICAM1, LDLR, SELP
2extracellular spaceGO:00056157.8SELP, ICAM1, CCL11, IFNA2, IL8, ALB
3extracellular regionGO:00055766.8ALB, SCGB1C1, SCGB1D4, RNASE3, CCL11, IFNA2

Biological processes related to Common Cold according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:00713479.8ICAM1, IL8
2regulation of cell adhesionGO:00301559.8IL8, ICAM1
3positive regulation of actin filament polymerizationGO:00308389.7CCL11, ICAM1
4leukocyte cell-cell adhesionGO:00071599.7ICAM1, SELP
5heterophilic cell-cell adhesionGO:00071579.7ICAM1, SELP
6inflammatory responseGO:00069549.2IL8, IFNA2, CCL11, SELP
7lipoprotein metabolic processGO:00421579.1ALB, LDLR

Molecular functions related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor activityGO:00302299.6LDLR, VLDLR
2calcium-dependent protein bindingGO:00483069.6SELP, VLDLR
3low-density lipoprotein receptor activityGO:00050419.3LDLR, VLDLR
4glycoprotein bindingGO:00019489.2LDLR, SELP, VLDLR
5protein bindingGO:00055156.8VLDLR, SELP, LDLR, ICAM1, CCL11, IFNA2

Products for genes affiliated with Common Cold

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  • Antibodies
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Sources for Common Cold

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet