MCID: CMM005
MIFTS: 59

Common Cold malady

Respiratory diseases category

Summaries for Common Cold

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards: Common Cold, also known as acute viral rhinopharyngitis, is related to influenza and asthma. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Spinal Cord Injury and TGF-Beta Pathway. The drugs ascorbic acid and phenylpropanolamine hydrochloride and the compounds anti-histamine and unicap have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotype immune system.

Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC:3 Español: El resfriado común y la secreción nasal o moqueo

Wikipedia:63 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza,head cold, or simply a... more...

Aliases & Classifications for Common Cold

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

common cold 8 10 44 33 60
acute viral rhinopharyngitis 8
nasopharyngitis - acute 8
nasopharyngitis, acute 8
acute nasopharyngitis 8
rhino-sinusitis 8
acute rhinitis 8
head cold, nos 8
acute coryza 8


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Disease Ontology8 DOID:10459
ICD9CM27 460
MeSH34 D003139
ICD1025 J00

Related Diseases for Common Cold

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Common Cold via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.7CCL11, LDLR
2asthma30.7IL5, RNASE3, LTC4S
3rhinitis30.5CCL11, ICAM1, RNASE3, IL5, IL8
4allergic rhinitis30.4CCL11, ICAM1, RNASE3, IL5, IL8
5otitis media30.2CCL11, MUC5B, RNASE3
6myocardial infarction29.9CCL11, SELP, LDLR
7bronchitis29.9CCL11, RNASE3, IL5, IL8
8melanoma29.9IL8, FLNC, ICAM1, IFNA2, CCL11
9viral infectious disease29.9CCL11, IFNA2, ICAM1, IL8, LDLR
10cystic fibrosis29.9FLNC, MUC5B, RNASE3, IL1R1, IL8
11eosinophilia29.9CCL11, IFNA2, FLNC, RNASE3, IL5, IL8
12nasopharyngitis10.3
13adenoiditis10.1
14nephrotic syndrome10.0CCL11
15pulmonary fibrosis10.0IL8
16malaria10.0ICAM1
17galactosemia10.0ICAM1
18conjunctivitis10.0RNASE3
19pemphigus vulgaris10.0CCL11
20myositis10.0ICAM1
21diabetic retinopathy10.0ICAM1
22respiratory failure10.0ICAM1
23liver cirrhosis10.0IFNA2
24dermatitis herpetiformis10.0CCL11
25hypertension10.0ICAM1
26meningitis10.0IL8
27graves' disease10.0ICAM1
28deficiency anemia10.0IFNA2
29hypersensitivity reaction type ii disease10.0ICAM1
30nephritis10.0IL1R1
31pulmonary disease, chronic obstructive10.0MUC5B
32bronchiolitis obliterans10.0IL8
33atopic dermatitis10.0RNASE3, CCL11
34aspergillosis10.0FLNC
35mastitis10.0IL8
36urticaria10.0RNASE3, LTC4S
37thromboembolism10.0SELP
38migraine10.0LDLR
39periodontitis10.0IL8
40hepatitis b10.0IFNA2
41lichen planus10.0ICAM1, IFNA2
42stroke, ischemic10.0SELP
43acute pancreatitis10.0IL8, IL1R1
44alcoholic hepatitis10.0IL8, ICAM1
45muckle-wells syndrome10.0IL1R1
46alopecia areata10.0ICAM1, IL1R1
47immunoglobulin a vasculitis10.0ICAM1, RNASE3
48adenocarcinoma10.0LDLR
49choroid cancer10.0KRTAP1-1, KRTAP1-3
50severe combined immunodeficiency10.0IL5

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Clinical Features for Common Cold

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Drugs & Therapeutics for Common Cold

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Common Cold

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Anatomical Context for Common Cold

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Sources:
32MalaCards
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MalaCards organs/tissues related to Common Cold:

32
Eye, Testes, T cells, Lung, Skin, Monocytes

Animal Models for Common Cold or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Common Cold:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2LDLR, SELP, IL8, IL1R1, IL5, LTC4S

Publications for Common Cold

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Sources:
50PubMed
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Articles related to Common Cold:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle. (24277846)
2013
2
Complementary treatment of the common cold and flu with medicinal plants--results from two samples of pharmacy customers in Estonia. (23484045)
2013
3
Appropriateness of prescriptions for common cold. (22678521)
2013
4
Parenthood, host resistance to the common cold, and impaired fertility. (23107840)
2012
5
Oral antihistamine-decongestant-analgesic combinations for the common cold. (22336807)
2012
6
African geranium (EPs 7630), part I: a proprietary root extract of Pelargonium sidoides (EPs 7630) is found to be effective in resolving symptoms associated with the common cold in adults. (22343933)
2012
7
Fixed-dose combinations for cough and common cold in India: an assessment of availability and rationality. (20584201)
2011
8
Bacterial pathogens of acute sinusitis in the osteomeatal complex during common colds and wellness. (22287466)
2011
9
Early ischemic lesions following subarachnoid hemorrhage: common cold remedy as precipitating factor? (21510236)
2011
10
Zinc lozenges as cure for the common cold--a review and hypothesis. (19906491)
2010
11
Viral etiology of common cold in children, Finland. (19193292)
2009
12
Common cold, uncommon variation. (19458372)
2009
13
Gas-phase electrophoretic molecular mobility analysis of size and stoichiometry of complexes of a common cold virus with antibody and soluble receptor molecules. (18260676)
2008
14
Treatment of the common cold. (17323712)
2007
15
Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. (18005909)
2007
16
Nasal decongestants for the common cold. (17253470)
2007
17
Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. (16844267)
2006
18
Major degradation product identified in several pharmaceutical formulations against the common cold. (17105185)
2006
19
Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial. (16454145)
2006
20
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. (16882099)
2006
21
Rhinovirus infections: more than a common cold. (17158286)
2006
22
Acute cooling of the feet and the onset of common cold symptoms. (16286463)
2005
23
Echinacea treatment for the common cold. (15736013)
2005
24
Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality? (16303679)
2005
25
Managing the common cold. (15754658)
2005
26
A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold. (16323289)
2005
27
Discolored nasal discharge did not increase the antibiotic prescription rate for the common cold patients. (15386698)
2005
28
Clinical trial of patulin in the common cold. 1944. (15082620)
2004
29
Knowledge and beliefs of primary care physicians, pharmacists, and parents on antibiotic use for the pediatric common cold. (14652058)
2004
30
Increase in common cold symptoms and mouth ulcers following smoking cessation. (12612369)
2003
31
Zinc nasal gel effective for the common cold. (12737760)
2003
32
Intake of vitamin C and zinc and risk of common cold: a cohort study. (11805584)
2002
33
Influence of attendance at day care on the common cold from birth through 13 years of age. (11814371)
2002
34
Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey. (12201356)
2002
35
Osteopathic treatment of the common cold. 1937. (11534526)
2001
36
Detection by reverse transcription-polymerase chain reaction of influenza C in nasopharyngeal secretions of adults with a common cold. (11262210)
2001
37
A cohort study of stress and the common cold. (11338315)
2001
38
Frostbite, a common cold injury: challenges in treatment and prevention. (10998824)
2000
39
Depressive state and common cold. (11036920)
2000
40
Evaluation of echinacea for treatment of the common cold. (10853625)
2000
41
Zinc gluconate and the common cold. Review of randomized controlled trials. (9612589)
1998
42
A cure for the common cold? Zinc again. (9643866)
1998
43
Radiological maxillary sinusitis in patients with common cold. (9673613)
1998
44
Cost and the common cold. (9005758)
1997
45
Vitamin C intake and susceptibility to the common cold. (9059230)
1997
46
Antibiotics and upper respiratory infection: do some folks think there is a cure for the common cold. (8627203)
1996
47
Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. (8684101)
1996
48
Vitamin C supplementation and common cold symptoms: problems with inaccurate reviews. (8974108)
1996
49
Consumer attitudes towards computer-assisted self-care of the common cold. (7971542)
1994
50
Dangers of common cold treatments in children. (7679769)
1993

Genetic Variations for Common Cold

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Expression for genes affiliated with Common Cold

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Common Cold

Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Common Cold according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL1R1, ICAM1
2
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10.0IL5, CCL11
3
Hide members
10.0IL5, CCL11
49.9ICAM1, IL1R1, IL8
59.8IFNA2, IL5, IL8
69.8CCL11, IL5, IL8
79.8ICAM1, IL5, IL8
89.7CCL11, IL5, SELP
9
Hide members
9.6IL1R1, IL5, ICAM1, IFNA2
10
Hide members
9.4IL5, RNASE3, ICAM1, IFNA2, CCL11
11
Hide members
9.1PLA2G2E, IL5, ICAM1, IFNA2, CCL11
12
Hide members
8.8CCL11, FLNC, IL5, IL1R1, IL8, PLA2G2E

Compounds for genes affiliated with Common Cold

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Common Cold according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1anti-histamine4410.3CCL11, ICAM1, RNASE3
2unicap4410.2RNASE3, IL5, CCL11
3loratadine44 11 2412.2ICAM1, RNASE3, IL8
4endotoxin4410.2ICAM1, AOAH, RNASE3
5levocabastine44 28 1112.1IL5, ICAM1, RNASE3
6roxithromycin44 28 1112.1IL8, CCL11, IL5
7sodium cromoglycate4410.0CCL11, IL5, ICAM1, RNASE3
8lte44410.0IL5, LTC4S, CCL11, RNASE3
9salmeterol44 49 28 1113.0IL8, RNASE3, CCL11, IL5
10ketotifen44 1111.0RNASE3, ICAM1, CCL11, IL5
11nedocromil sodium4410.0RNASE3, ICAM1, IL8, IL5
12pranlukast44 28 1112.0IL5, CCL11, RNASE3
13salbutamol44 49 28 11 2414.0RNASE3, CCL11, IL5, IL8
14ccl344 2811.0ICAM1, IL1R1, IL8, CCL11
15ltc44410.0RNASE3, LTC4S, CCL11, IL5
16fluticasone propionate44 49 59 1113.0CCL11, RNASE3, IL8, IL5
17azelastine44 1111.0ICAM1, RNASE3, IL5
18pgd2449.9IL5, RNASE3, LTC4S, CCL11
19sele449.9ICAM1, SELP, LDLR
20tarc449.9ICAM1, CCL11, IL8, IL5
21ltd4449.9IL5, LTC4S, RNASE3
22neopterin449.9IFNA2, ICAM1, IL1R1, IL8
23rantes449.9IL1R1, CHIA, CCL11, ICAM1, RNASE3
24pentoxifylline44 1110.9IL1R1, ICAM1, IL8, SELP
25cetirizine44 28 11 2412.9IL5, RNASE3, ICAM1, CCL11, IL8
26clarithromycin44 1110.9CCL11, IL5, IL8
27montelukast44 49 28 1112.8RNASE3, CCL11, IL5, LTC4S, IL8
28il-12449.8IL5, IL1R1, IL8
29methacholine44 1110.8IL8, IL5, RNASE3, ICAM1, CCL11
30hyaluronic acid44 2410.8RNASE3, CCL11, IL8, ICAM1, IL1R1
31prednisolone44 28 1111.8CCL11, IFNA2, RNASE3, IL5, IL1R1
32dextran sulfate449.7LDLR, ICAM1, IL5, SELP
33n acetylcysteine449.6SELP, CCL11, IL8, RNASE3, ICAM1, IL1R1
34budesonide44 49 1111.6RNASE3, SELP, IL8, ICAM1, CCL11, IL5
35n-formylmethionyl-leucylphenylalanine449.6CCL11, SELP, IL8, IL5, RNASE3, ICAM1
36fmlp449.5IL8, SELP, RNASE3, ICAM1, CCL11, IL5
37aspirin44 49 28 2412.5RNASE3, CCL11, LTC4S, IL1R1, LDLR, SELP
38sb 20358044 5910.4ICAM1, IL5, IL1R1, IL8, CCL11
39leukotriene b444 59 2411.3IL1R1, SELP, CCL11, LTC4S, RNASE3, IL8
40heparin44 28 11 2412.3LDLR, CCL11, IL8, IL1R1, RNASE3, VLDLR
41indomethacin44 59 28 1112.3CCL11, IFNA2, IL5, LDLR, IL1R1
42genistein44 28 59 2 11 2414.3IL5, ICAM1, CCL11, IL8, SELP, LDLR
43histamine44 28 2411.2SELP, CCL11, IFNA2, IL8, IL5, ICAM1
44vegf449.1IL8, IL5, IL1R1, SELP, ICAM1, IFNA2
45cyclosporin a44 28 5911.0SELP, CCL11, LDLR, ICAM1, RNASE3, IL8
46retinoic acid44 249.9LDLR, IL5, RNASE3, ICAM1, SELP, CCL11
47pge2448.8LTC4S, CCL11, SELP, LDLR, IL8, IL1R1
48dexamethasone44 49 28 1111.8SELP, LDLR, CCL11, ICAM1, LTC4S, RNASE3
49lipid448.7LDLR, IL1R1, RNASE3, LTC4S, VLDLR, CHIA
50tyrosine448.2ICAM1, IFNA2, CCL11, VLDLR, SELP, IL1R1

GO Terms for genes affiliated with Common Cold

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16Gene Ontology
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Cellular components related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9IFNA2, ICAM1, CHIA, IL5, IL8, SELP
2extracellular regionGO:0055766.3KRTAP1-1, CCL11, IFNA2, SCGB1D4, SCGB1C1, AOAH

Biological processes related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3IL8, IL1R1, IL5, CHIA, CCL11
2inflammatory responseGO:0069548.2SELP, CCL11, IFNA2, AOAH, IL5, IL8

Molecular functions related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein receptor activityGO:00504110.0LDLR, VLDLR
2very-low-density lipoprotein particle receptor activityGO:0302299.7LDLR, VLDLR
3glycoprotein bindingGO:0019489.6LDLR, SELP, VLDLR

Products for genes affiliated with Common Cold

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Cold

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet