MCID: CMM005
MIFTS: 63

Common Cold malady

Respiratory diseases category
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Summaries for Common Cold

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Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. it is probably the most common illness. in the course of a year, people in the united states suffer 1 billion colds. you can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. you can also inhale the germs. symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. washing your hands and staying away from people with colds will help you avoid colds. there is no cure for the common cold. for relief, try getting plenty of rest drinking fluids gargling with warm salt water using cough drops or throat sprays taking over-the-counter pain or cold medicines however, do not give aspirin to children. and do not give cough medicine to children under four. nih: national institute of allergy and infectious diseases

MalaCards: Common Cold, also known as acute viral rhinopharyngitis, is related to asthma and sinusitis. An important gene associated with Common Cold is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine Network and TSLP Signaling Pathway. The drugs sodium ascorbate and pseudoephedrine and the compounds anti-histamine and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are vision/eye and hematopoietic system.

Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. this is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC:4 Español: El resfriado común y la secreción nasal o moqueo

Wikipedia:65 The common cold (also known as nasopharyngitis, rhinopharyngitis, acute coryza,head cold, or simply a... more...

Aliases & Classifications for Common Cold

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

common cold 8 10 45 34 62
acute viral rhinopharyngitis 8
nasopharyngitis - acute 8
nasopharyngitis, acute 8
acute nasopharyngitis 8
rhino-sinusitis 8
acute rhinitis 8
head cold, nos 8
acute coryza 8


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Disease Ontology8 DOID:10459
ICD9CM27 460
MeSH35 D003139
ICD1025 J00

Related Diseases for Common Cold

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Common Cold via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1asthma30.8RNASE3, ICAM1, CCL11, IL8
2sinusitis30.8RNASE3, CCL11
3rhinitis30.6RNASE3, ICAM1, CCL11, IL8, ALB
4allergic rhinitis30.5RNASE3, ICAM1, CCL11, IL8
5otitis media30.5CCL11, RNASE3
6bronchitis30.1RNASE3, CCL11, IL8
7eosinophilia30.0RNASE3, CCL11, IFNA2, IL8
8cystic fibrosis30.0ALB, IL8, IL1R1, RNASE3
9viral infectious disease29.9LDLR, ICAM1, CCL11, IFNA2, IL8
10myocardial infarction29.9SELP, LDLR, CCL11
11blindness10.7
12influenza10.5
13nasopharyngitis10.4
14adenoiditis10.2
15eosinophilic gastroenteritis10.1CCL11
16conjunctivitis10.1RNASE3
17polyarteritis nodosa10.1IFNA2
18bronchiolitis obliterans10.1IL8
19muckle-wells syndrome10.1IL1R1
20chronic eosinophilic pneumonia10.1RNASE3, CCL11
21giant papillary conjunctivitis10.1RNASE3, CCL11
22atopy10.1RNASE3, CCL11
23allergic conjunctivitis10.1RNASE3, CCL11
24keratoconjunctivitis10.1RNASE3, CCL11
25eosinophilic pneumonia10.1RNASE3, CCL11
26food allergy10.1RNASE3, CCL11
27immunoglobulin a vasculitis10.1ICAM1, RNASE3
28alcoholic hepatitis10.1ICAM1, IL8
29hypereosinophilic syndrome10.1CCL11, RNASE3
30bronchopulmonary dysplasia10.1RNASE3, IL8
31bronchiectasis10.1RNASE3, IL8
32lichen planus10.1ICAM1, IFNA2
33respiratory failure10.1RNASE3, CCL11
34malaria10.1ALB, ICAM1
35bronchiolitis10.1RNASE3, CCL11, IL8
36behcet's disease10.1IFNA2, IL8
37pulmonary eosinophilia10.1IL8, CCL11, RNASE3
38skin disease10.1ALB
39bacterial vaginosis10.1IL1R1, IL8
40alopecia areata10.1ICAM1, IL1R1
41bullous pemphigoid10.1RNASE3, CCL11
42chorioamnionitis10.1IL1R1, IL8
43pneumonia10.1ICAM1, CCL11, IL8
44pulmonary disease, chronic obstructive10.1IL8, CCL11, RNASE3
45arteriosclerosis10.1ICAM1, LDLR
46mastitis10.1ALB, IL8
47cork-handlers' disease10.1RNASE3, CCL11, IL8
48alcoholic liver cirrhosis10.1ALB, IL8
49ulcerative colitis10.1ALB
50interstitial lung disease10.0CCL11, IL1R1, IL8

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to common cold

Symptoms for Common Cold

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Drugs & Therapeutics for Common Cold

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Common Cold

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Anatomical Context for Common Cold

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33MalaCards
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MalaCards organs/tissues related to Common Cold:

33
Eye, Testes, T cells, Skin, Lung, Monocytes

Animal Models for Common Cold or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Common Cold:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4IL1R1, ICAM1, LDLR, SELP, VLDLR
2MP:00053978.0SELP, LDLR, ICAM1, CCL11, IL1R1, IL8
3MP:00053877.8SELP, LDLR, ICAM1, CCL11, IL1R1, IL8
4MP:00053847.7ALB, IL1R1, ICAM1, LDLR, SELP, VLDLR

Publications for Common Cold

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Sources:
52PubMed
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Articles related to Common Cold:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
The common cold: potential for future prevention or cure. (24415465)
2014
2
Intranasal ipratropium bromide for the common cold. (23784858)
2013
3
Associations between mental disorders and the common cold in adults: a population-based cross-sectional study. (23272991)
2013
4
Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle. (24277846)
2013
5
A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school children. (23930726)
2013
6
Complementary treatment of the common cold and flu with medicinal plants--results from two samples of pharmacy customers in Estonia. (23484045)
2013
7
Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. (22566526)
2012
8
Not curing the common cold. (23034853)
2012
9
Zinc for the common cold. (21328251)
2011
10
North American (Panax quinquefolius) and Asian Ginseng (Panax ginseng) Preparations for Prevention of the Common Cold in Healthy Adults: A Systematic Review. (19592479)
2011
11
Antibiotics for the common cold: expectations of Germany's general population. (20822733)
2010
12
Non-steroidal anti-inflammatory drugs for the common cold. (19588387)
2009
13
Is intranasal zinc effective and safe for the common cold? A systematic review and meta-analysis. (20690364)
2009
14
Do Japanese style acupuncture and moxibustion reduce symptoms of the common cold? (18955215)
2008
15
Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold. (18832713)
2008
16
Treatment of the common cold. (17323712)
2007
17
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
18
Echinacea for preventing and treating the common cold. (16437427)
2006
19
Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. (16844267)
2006
20
Antibiotic prescribing for children with nasopharyngitis (common colds), upper respiratory infections, and bronchitis who have health-professional parents. (16199689)
2005
21
Echinacea, vitamin C, the common cold, and blinding. (16080106)
2005
22
Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common cold. (15673581)
2005
23
Is there a common cold constitution? (12135399)
2002
24
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
25
Complementary and alternative therapies for the common cold. (11174218)
2001
26
Natural alternatives for the common cold: hype or hope? (11280018)
2001
27
Antivirals for the common cold. (11687023)
2001
28
Capillary electrophoresis with postcolumn infectivity assay for the analysis of different serotypes of human rhinovirus (common cold virus). (10857634)
2000
29
Herbs and the common cold. (11761519)
2000
30
Antibiotics and the common cold. (11127363)
2000
31
Common cold. Zinc update. (11114798)
2000
32
The relationship between the frequency of the common cold and the activities of natural killer cells. (21432487)
2000
33
The common cold as a trigger of asthma. (11272635)
2000
34
Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. (10589439)
1999
35
The role of the common cold in asthma. (10073322)
1999
36
The common cold. (9866136)
1998
37
Sinusitis in the common cold. (9768580)
1998
38
JAMA patient page: the common cold. (9643869)
1998
39
Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): relationship to symptoms of the common cold and studying behavior. (9494693)
1998
40
Zinc gluconate and the common cold. Review of randomized controlled trials. (9612589)
1998
41
Zinc gluconate lozenges for treating the common cold. (9882105)
1997
42
Changes in nasal nitric oxide concentration associated with symptoms of common cold and treatment with a topical nasal decongestant. (9288222)
1997
43
Cost and the common cold. (9005758)
1997
44
Common cold and high-dose ipratropium bromide: use of anticholinergic medication as an indicator of reflex-mediated hypersecretion. (9299652)
1997
45
Caffeine and the common cold. (9443519)
1997
46
Futility and the common cold. How requests for antibiotics can illuminate care at the end of life. (7874961)
1995
47
Asthma and the common cold: can viruses imitate worms? (8128395)
1994
48
CT scans and the common cold? (8190165)
1994
49
Dangers of common cold treatments in children. (7679769)
1993
50
Use of retail pharmacy for common cold preparations in urban Harare. (8181443)
1993

Variations for Common Cold

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Expression for genes affiliated with Common Cold

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Common Cold

Search GEO for disease gene expression data for Common Cold.

Pathways for genes affiliated with Common Cold

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 55Reactome, 30KEGG
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Pathways related to Common Cold according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL8, IFNA2
29.9CCL11, IL8
39.8IL8, ICAM1
49.8IL8, ICAM1
5
Show member pathways
9.5ICAM1, CCL11, IL8
6
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5IFNA2, IL1R1, IL8
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5IL8, IL1R1, CCL11
8
Show member pathways
9.5IL1R1, IFNA2, ICAM1
99.4IL8, IFNA2, LDLR
109.4ICAM1, IL1R1, IL8
119.3IL8, ICAM1, SELP
12
Show member pathways
9.3RNASE3, ICAM1, CCL11, IFNA2
13
Show member pathways
9.2CCL11, IFNA2, IL1R1, IL8
14
Show member pathways
9.2IL8, IL1R1, IFNA2, CCL11
15
Show member pathways
thioredoxin pathway38
9.1LDLR, ICAM1, ALB
168.9IL8, IL1R1, ICAM1, SELP

Compounds for genes affiliated with Common Cold

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Common Cold according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1anti-histamine459.9ICAM1, CCL11, RNASE3
2sodium cromoglycate459.9RNASE3, CCL11, ICAM1
3nedocromil sodium459.9RNASE3, IL8, ICAM1
4salmeterol45 51 29 1112.9RNASE3, CCL11, IL8
5loratadine45 24 1111.9RNASE3, ICAM1, IL8
6ketotifen45 1110.8ICAM1, CCL11, RNASE3
7montelukast45 51 29 1112.8RNASE3, IL8, CCL11
8cetirizine45 29 24 1112.7ICAM1, IL8, CCL11, RNASE3
9methacholine45 51 1111.6ICAM1, RNASE3, IL8, CCL11
10neopterin459.5IFNA2, IL8, ICAM1, IL1R1
11ccl345 2910.5IL1R1, ICAM1, IL8, CCL11
12sele459.5SELP, ICAM1, LDLR
13groalpha459.4CCL11, ICAM1, IL8
14cuprophan459.4ICAM1, IL1R1, SELP
15polymyxin b459.4IL8, ICAM1, LDLR
16troglitazone45 29 61 1112.3IL8, CCL11, LDLR, ICAM1
17pentoxifylline45 1110.3IL8, IL1R1, ICAM1, SELP
18endotoxin459.2CCL11, ICAM1, IL1R1, IL8, RNASE3
19polyethylene glycol459.2ALB, IL1R1, IFNA2, ICAM1
20budesonide45 51 1111.2IL8, CCL11, ICAM1, RNASE3, SELP
21n-formylmethionyl-leucylphenylalanine459.1SELP, RNASE3, ICAM1, CCL11, IL8
22fmlp459.1ICAM1, CCL11, SELP, RNASE3, IL8
23leukotriene b445 61 2411.1SELP, CCL11, IL8, IL1R1, RNASE3
24prednisolone45 29 1111.0CCL11, IFNA2, IL1R1, RNASE3, ALB
25polysulfone459.0IL1R1, SELP, ALB
26mannitol45 1110.0IFNA2, ALB, SELP, ICAM1
27simvastatin45 51 61 29 24 1113.9SELP, LDLR, ICAM1, IL8
28actinomycin d458.9IL8, IL1R1, LDLR, ICAM1, CCL11
29dextran sulfate458.9LDLR, SELP, ALB, ICAM1
30aspirin45 51 29 2411.9LDLR, SELP, RNASE3, CCL11, IL1R1
31indomethacin45 29 61 1111.8CCL11, IFNA2, LDLR, IL1R1, ALB
32genistein45 29 61 3 24 1113.8ICAM1, SELP, LDLR, CCL11, IL8
33ascorbic acid45 249.7ICAM1, IL1R1, ALB, LDLR, IFNA2
34rantes458.7CCL11, ICAM1, RNASE3, IL8, IL1R1, SELP
35n acetylcysteine458.7IL8, IL1R1, SELP, CCL11, ICAM1, RNASE3
36hyaluronic acid45 249.6IL8, IL1R1, CCL11, ICAM1, RNASE3, ALB
37fibrinogen458.6RNASE3, ICAM1, IL1R1, ALB, SELP
38nitric oxide45 24 1110.5SELP, IL8, IL1R1, CCL11, ICAM1, RNASE3
39fatty acid458.5IFNA2, IL1R1, VLDLR, ALB, LDLR
40vegf458.4IL8, IL1R1, IFNA2, CCL11, SELP, RNASE3
41lactate458.4IL8, IL1R1, ALB, ICAM1, RNASE3, SELP
42retinoic acid45 249.3SELP, IFNA2, LDLR, ICAM1, IL1R1, RNASE3
43cyclosporin a45 29 6110.3ICAM1, SELP, IL8, IL1R1, CCL11, LDLR
44pge2458.3CCL11, IL1R1, IL8, LDLR, RNASE3, SELP
45histamine45 29 2410.3IL8, SELP, RNASE3, ICAM1, CCL11, IFNA2
46dexamethasone45 51 29 1111.3CCL11, IL1R1, IL8, ICAM1, LDLR, RNASE3
47lipid458.1CCL11, ALB, IL1R1, VLDLR, RNASE3, IFNA2
48creatinine457.9ALB, VLDLR, RNASE3, SELP, IL1R1
49cysteine457.9IL1R1, ALB, IFNA2, LDLR, SELP, IL8
50heparin45 29 24 1110.6ALB, VLDLR, SELP, RNASE3, LDLR, CCL11

GO Terms for genes affiliated with Common Cold

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16Gene Ontology
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Cellular components related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2ICAM1, LDLR, SELP
2extracellular spaceGO:0056157.8SELP, ICAM1, CCL11, IFNA2, IL8, ALB
3extracellular regionGO:0055766.8ALB, SCGB1C1, SCGB1D4, RNASE3, CCL11, IFNA2

Biological processes related to Common Cold according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-1GO:0713479.8ICAM1, IL8
2regulation of cell adhesionGO:0301559.8IL8, ICAM1
3positive regulation of actin filament polymerizationGO:0308389.7CCL11, ICAM1
4leukocyte cell-cell adhesionGO:0071599.7ICAM1, SELP
5heterophilic cell-cell adhesionGO:0071579.7ICAM1, SELP
6inflammatory responseGO:0069549.2IL8, IFNA2, CCL11, SELP
7lipoprotein metabolic processGO:0421579.1ALB, LDLR

Molecular functions related to Common Cold according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle receptor activityGO:0302299.6LDLR, VLDLR
2calcium-dependent protein bindingGO:0483069.6SELP, VLDLR
3low-density lipoprotein receptor activityGO:0050419.3LDLR, VLDLR
4glycoprotein bindingGO:0019489.2LDLR, SELP, VLDLR
5protein bindingGO:0055156.8VLDLR, SELP, LDLR, ICAM1, CCL11, IFNA2

Products for genes affiliated with Common Cold

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Cold

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet