CVID
MCID: CMM004
MIFTS: 66

Common Variable Immunodeficiency (CVID) malady

Immune diseases category

Summaries for Common Variable Immunodeficiency

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Common variable immunodeficiency is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that may cause infection.  the main features that separate cvid from other immunodeficiencies are low levels of two specific antibodies, immunoglobulin a (iga) and immunoglobulin g (igg).  individuals with this condition develop more frequent infections, particularly in the sinuses, lungs, and digestive tract.   cvid symptoms most commonly begin in early adulthood, but have been found in children as young as two years.  though some cases of cvid are caused by known genetic factors, the cause of most cases is unknown.   cvid can sometimes be treated by "replacing" antibodies into the body; this treatment is called "immunoglobulin therapy".  last updated: 10/25/2010

MalaCards: Common Variable Immunodeficiency, also known as common variable agammaglobulinemia, is related to pneumonia and purpura. An important gene associated with Common Variable Immunodeficiency is MSH5 (mutS homolog 5), and among its related pathways are Primary immunodeficiency and TNF Signaling. The compounds blys and bcma have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low ig levels with phenotypically normal b cells that can proliferate but do not develop into ig-producing cells. patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin g (igg) and immunoglobulin a (iga); about half of these patients also have reduced immunoglobulin m (igm).

Description from OMIM:46 613493, 613494, 613495, 240500, 607594 613496 more

Aliases & Classifications for Common Variable Immunodeficiency

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 30LifeMap Discovery™, 60UMLS, 22GTR, 39NCIt, 27ICD9CM, 46OMIM, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

common variable immunodeficiency 8 42 30 60
common variable agammaglobulinemia 8 22
acquired hypogammaglobulinemia 8 60
cvid 8 42
common variable hypogamma-globulinemia 42
immunoglobulin deficiency, late-onset 42
hypogamma-globulinemia, acquired 42
sporadic hypogammaglobulinemia 8
acquired agammaglobulinemia 8


External Ids:

Disease Ontology8 DOID:12177
NCIt39 C26725
ICD9CM27 279.06
SNOMED-CT56 191010004, 23238000
MeSH34 D017074

Related Diseases for Common Variable Immunodeficiency

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Common Variable Immunodeficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.8MBL2, BTK, CD79A, IL2RB, SELL
2purpura30.7CD79A
3hepatitis30.7CD40LG, IL2RB, SELL
4common variable immune deficiency30.7ICOS, TNFRSF13C, TNFRSF13B
5interstitial lung disease30.6CD79A
6meningitis30.6CD79A, MBL2
7sarcoidosis30.6CD86, CD27, CD28, IL2RB, IL2
8arthritis30.6IL2RB, IL4, CD86
9autoimmune hemolytic anemia30.6CD40LG, CD79A
10bronchiectasis30.6CD79A, MBL2
11agammaglobulinemia30.5IL2, IL4, CD79A, CD40LG, BTK, SH2D1A
12systemic lupus erythematosus30.5CD27, TNFSF13B
13lupus erythematosus30.5CD79A, CD40LG
14celiac disease30.5CD79A
15hepatitis c30.5TNFSF13B, CD40LG, CD28, IL4, IL2
16asthma30.4MBL2, TNFSF13B, AICDA, SELL, IL4, CD28
17influenza30.4MBL2, CD86, CD27, CD79A, CD28, IL2RB
18uveitis30.4IL4
19diarrhea30.4IL2, CD79A
20herpes simplex30.4CD79A
21infectious mononucleosis30.4SH2D1A, CD40LG, CD79A, IL2RB
22rheumatoid arthritis30.3SELL, IL2, IL2RB, IL4, CD28, CD79A
23leukemia30.3BTK, AICDA, SH2D1A, VPREB1, MBL2, CD86
24thrombocytopenia30.3AICDA, CD40LG, CD79A, IL2
25hodgkin's lymphoma30.3TNFSF13B, SH2D1A, AICDA, CD28, IL2RB, IL2
26neutropenia30.3MBL2, BTK
27hypertension30.3CD79A
28inflammatory bowel disease30.3SELL, IL4, CD28, CD86
29non-hodgkin lymphoma30.1TNFSF13B, TNFRSF13C, TNFRSF13B, SH2D1A, SELL, IL2
30multiple sclerosis30.1IL2, IL2RB, IL4, CD28, CD27, CD86
31vasculitis30.1MBL2, TNFSF13B, SH2D1A, CD40LG, CD79A, SELL
32rhinitis30.1IL4, CD79A
33allergic rhinitis30.1MBL2, IL4
34dermatitis30.1IL4, CD79A
35severe combined immunodeficiency30.1IL4, IL2RB, IL2
36pemphigus30.1CD79A
37gastritis30.1CD79A
38deficiency anemia30.1IL2, CD79A
39wiskott-aldrich syndrome30.1SH2D1A, BTK, CD28
40encephalomyelitis30.1TNFSF13B, CD86, IL4, IL2
41allergic asthma30.1AICDA, CD86, IL4, IL2RB, SELL
42glomerulonephritis30.1MBL2, CD40LG, CD79A, CD28
43cystic fibrosis30.1MBL2
44leishmaniasis30.1IL4
45ulcerative colitis30.1CD86, CD79A, CD28, IL4, SELL
46nephrotic syndrome30.1CD79A
47myocardial infarction30.1SELL
48aspergillosis30.1CD79A, MBL2
49hepatocellular carcinoma30.1AICDA, CD86
50acquired immunodeficiency syndrome30.0IL2

Graphical network of the top 20 diseases related to Common Variable Immunodeficiency:



Diseases related to common variable immunodeficiency

Clinical Features for Common Variable Immunodeficiency

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46OMIM
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Clinical features from OMIM:

613493,613494,613495,240500,607594,613496

Drugs & Therapeutics for Common Variable Immunodeficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Common Variable Immunodeficiency

Drug clinical trials:

Search ClinicalTrials for Common Variable Immunodeficiency

Search NIH Clinical Center for Common Variable Immunodeficiency

Search CenterWatch for Common Variable Immunodeficiency

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Common Variable Immunodeficiency cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Common Variable Immunodeficiency:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Embryonic/Adult Cultured Cells Related to Common Variable Immunodeficiency:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905

Genetic Tests for Common Variable Immunodeficiency

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Sources:
22GTR
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Genetic tests related to Common Variable Immunodeficiency:

id Genetic test Affiliating Genes
1 Common Variable Agammaglobulinemia22

Anatomical Context for Common Variable Immunodeficiency

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Sources:
32MalaCards
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MalaCards organs/tissues related to Common Variable Immunodeficiency:

32
B cells, T cells, Lung, Liver, Bone, Monocytes, Testes, Bone marrow, Whole blood, Brain, Skin, Smooth muscle, Small intestine

Animal Models for Common Variable Immunodeficiency or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Common Variable Immunodeficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.7ICOS, IL2, IL2RB, IL4, CD28, CD79A
2MP:000538710.7ICOS, SELL, IL2, IL2RB, IL4, CD28
3MP:000538410.6SH2D1A, TNFRSF13B, TNFSF13B, TNFRSF13C, VPREB1, ICOS
4MP:000537610.5ICOS, MBL2, TNFRSF13C, TNFRSF13B, SH2D1A, BTK
5MP:001077110.5SELL, CD40LG, BTK, AICDA
6MP:000537910.4CD86, CD40LG, IL4, IL2RB, IL2, MSH5
7MP:000200610.2TNFRSF13B, AICDA, BTK, CD28, IL2

Publications for Common Variable Immunodeficiency

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50PubMed
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Articles related to Common Variable Immunodeficiency:

(show top 50)    (show all 618)
idTitleAuthorsYear
1
Organising pneumonia in common variable immunodeficiency. (23749855)
2013
2
Common variable immunodeficiency - new insight into the pathogenesis and the quest for a workable classification. (23830379)
2013
3
Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (22930256)
2013
4
Familial pyoderma gangrenosum in association with common variable immunodeficiency. (23662950)
2013
5
Common variable immunodeficiency-associated granulomatous and interstitial lung disease. (23880700)
2013
6
Common variable immunodeficiency. (23883805)
2013
7
Lymphocytes and B-cell abnormalities in patients with common variable immunodeficiency (CVID). (23305827)
2013
8
Emergence of a multidrug-resistant Haemophilus influenzae strain causing chronic pneumonia in a patient with common variable immunodeficiency. (23095085)
2013
9
Health related quality of life in common variable immunodeficiency. (22477006)
2012
10
Immunophenotyping of putative human B1 B cells in healthy controls and common variable immunodeficiency (CVID) patients. (23121674)
2012
11
Epstein-Barr Virus-Associated Adrenal Smooth Muscle Tumors and Disseminated Diffuse Large B-Cell Lymphoma in a Child With Common Variable Immunodeficiency: A Case Report and Review of the Literature. (21454372)
2011
12
Chronic anterior uveitis in common variable immunodeficiency. (22106916)
2011
13
Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients. (21300572)
2011
14
A CT scan score for the assessment of lung disease in children with common variable immunodeficiency disorders. (20299624)
2010
15
Common variable immunodeficiency at the end of a prospering decade: towards novel gene defects and beyond. (20864887)
2010
16
T-cell response to viral antigens in adults and children with common variable immunodeficiency and specific antibody deficiency. (20408855)
2010
17
Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia. (20051045)
2010
18
ABO discrepancy in a young Korean serviceman with common variable immunodeficiency. (19844713)
2010
19
CD21low B cells in common variable immunodeficiency do not show defects in receptor editing, but resemble tissue-like memory B cells. (21051568)
2010
20
Analysis of the sputum and inflammatory alterations of the airways in patients with common variable immunodeficiency and bronchiectasis. (20037702)
2009
21
Common variable immunodeficiency. (19190529)
2009
22
An update on treatment strategies for common variable immunodeficiency. (20477035)
2009
23
Hepatitis in common variable immunodeficiency. (19084266)
2009
24
High resolution computed tomography and pulmonary function in common variable immunodeficiency. (19181508)
2009
25
Autoimmune manifestations in common variable immunodeficiency. (18322785)
2008
26
Co-existence of common variable immunodeficiency (CVID) with idiopathic thrombocytopenic purpura (ITP). (18319527)
2008
27
Screening of functional and positional candidate genes in families with common variable immunodeficiency. (18254984)
2008
28
Progression of selective IgA deficiency to common variable immunodeficiency. (18520152)
2008
29
Sequence analysis of BIRC4/XIAP in male patients with common variable immunodeficiency. (18520160)
2008
30
Anti-tumour necrosis factor-alpha therapy for severe enteropathy in patients with common variable immunodeficiency (CVID). (17822445)
2007
31
Response of refractory immune thrombocytopenic purpura in a patient with common variable immunodeficiency to treatment with rituximab. (17483248)
2007
32
Analysis of genetic defects in patients with the common variable immunodeficiency phenotype in a single Taiwanese tertiary care hospital. (18051214)
2007
33
TACI mutation in common variable immunodeficiency and IgA deficiency. (16899196)
2006
34
Common variable immunodeficiency: The power of co-stimulation. (17023177)
2006
35
Abnormal interleukin-7 function in common variable immunodeficiency. (15598813)
2005
36
Chlamydia pneumoniae arthritis in a patient with common variable immunodeficiency. (15875533)
2005
37
Deficiency of somatic hypermutation of immunoglobulin G transcripts is a better predictor of severe respiratory tract infections than lack of memory B cells in common variable immunodeficiency. (16133996)
2005
38
Atypical PML leading to a diagnosis of common variable immunodeficiency. (15883345)
2005
39
Autoimmune thrombocytopenic purpura and common variable immunodeficiency: analysis of 21 cases and review of the literature. (15232313)
2004
40
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. (12577056)
2003
41
HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama. (12803653)
2003
42
Common variable immunodeficiency with mosaic trisomy 8: report of one case. (11198941)
2000
43
Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients. (10760795)
2000
44
Alopecia universalis in a patient with common variable immunodeficiency. (10469418)
1999
45
Common variable immunodeficiency with CD4+ T lymphocytopenia and overproduction of soluble IL-2 receptor associated with Turner's syndrome and dorsal kyphoscoliosis. (9462277)
1997
46
Unexplained remission of common variable immunodeficiency: analysis of a clinical case]. (9041731)
1996
47
Salivary defense factors and oral health in patients with common variable immunodeficiency. (7929697)
1994
48
Failure of c-myc gene expression in B cells of some patients with common variable immunodeficiencies. (1283307)
1992
49
Acute interstitial pneumonia in a patient with BehAset's syndrome and common variable immunodeficiency. (2297140)
1990
50
The capacity of interleukin-4 to induce in vitro IgE synthesis by B cells of patients with common variable immunodeficiency. (2119918)
1990

Genetic Variations for Common Variable Immunodeficiency

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Expression for genes affiliated with Common Variable Immunodeficiency

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Common Variable Immunodeficiency

Search GEO for disease gene expression data for Common Variable Immunodeficiency.

Pathways for genes affiliated with Common Variable Immunodeficiency

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Sources:
29KEGG, 55SinoBiological, 52R&D Systems, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Common Variable Immunodeficiency according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5CD79A, ICOS, TNFRSF13C, TNFRSF13B, AICDA, BTK
2
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10.5TNFRSF13C, TNFSF13B, TNFRSF13B, BTK, CD40LG, CD27
3
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10.5ICOS, TNFRSF13C, TNFSF13B, TNFRSF13B, AICDA, CD86
4
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10.5TNFRSF13C, TNFSF13B, TNFRSF13B, BTK, CD27, CD28
5
Hide members
10.5BTK, TNFRSF13B, TNFSF13B, TNFRSF13C
6
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10.5TNFRSF13C, TNFSF13B, TNFRSF13B
7
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10.5IL4, CD28, BTK, TNFRSF13B, TNFSF13B, TNFRSF13C
8
Hide members
10.5IL2RB, CD28, BTK, TNFRSF13B, TNFSF13B, TNFRSF13C
910.5CD40LG, BTK, TNFSF13B, TNFRSF13C
1010.5TNFSF13B, SH2D1A, AICDA, BTK, CD79A, IL4
11
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.5CD40LG, TNFRSF13B, TNFSF13B
12
Hide members
10.5ICOS, MBL2, BTK, CD86, CD40LG, CD79A
13
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10.5TNFRSF13C, TNFRSF13B, BTK, CD28, IL2RB
14
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10.5TNFRSF13C, TNFSF13B, BTK, IL4, IL2RB, IL2
15
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10.5ICOS, BTK, CD40LG, CD79A, CD28, IL4
16
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10.5IL2, IL4, CD79A, BTK, SH2D1A
1710.5ICOS, CD86, CD40LG, CD28, SELL
18
Hide members
10.5BTK, CD79A, IL4, IL2RB, IL2
19
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10.5ICOS, CD86, CD28, IL2RB, IL2
20
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10.5CD40LG, IL4, IL2
21
Immune response ICOS pathway in T-helper cell
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10.5CD28, CD86, ICOS
22
Hide members
10.5CD28, CD86, ICOS
2310.5IL4, CD40LG, AICDA
24
Hide members
10.5CD28, CD79A, CD86, BTK
25
Immune response NFAT in immune response
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10.5BTK, CD86, CD79A, CD28
26
Hide members
10.5SH2D1A, CD28, IL4, IL2RB, IL2
2710.5TNFSF13B, CD86, CD28
2810.5CD86, CD40LG, CD28, IL4, IL2RB, IL2
29
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10.5IL2, IL2RB, IL4
30
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10.5IL4, IL2RB, IL2
31
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10.5IL2, CD28, CD86
3210.5IL2, IL2RB, CD28, CD86
33
Hide members
10.5CD86, CD28, IL4

Compounds for genes affiliated with Common Variable Immunodeficiency

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Common Variable Immunodeficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1blys4411.0TNFRSF13C, CD79A, TNFSF13B, TNFRSF13B, CD40LG
2bcma4410.9TNFRSF13B, CD27, TNFSF13B, TNFRSF13C
3ivig4410.9CD79A, IL4, IL2RB, CD40LG, BTK, AICDA
4neopterin4410.9MBL2, CD40LG, CD79A, IL2, IL2RB, IL4
5con a4410.9IL2, IL2RB, IL4, CD28, CD79A, MBL2
6histamine44 28 2412.9SELL, IL2RB, IL4, CD79A, CD40LG, CD86
7okt34410.9IL2, IL2RB, IL4, CD79A, CD40LG
8ionomycin4410.9IL4, IL2RB, IL2, CD28, SELL, BTK
9dexamethasone44 49 28 1113.9SELL, CD86, CD40LG, CD79A
10ctla4-ig4410.9IL2RB, CD28, CD86, IL2
11il-124410.9IL2, CD40LG, CD86, IL4
12tacrolimus44 49 1112.9IL4, IL2RB, IL2, CD28, CD86, CD79A
13cyclosporin a44 28 5912.9CD86, IL2RB, IL2, IL4, CD40LG, CD28
14pge24410.9IL2
15biotin44 11 2412.9CD40LG, CD79A, IL4, SELL, IL2
16rantes4410.9MBL2, IL4, IL2RB, IL2, SELL, CD40LG
17mycophenolate mofetil44 49 1112.9CD40LG, CD79A, IL2RB, IL2
18prednisolone44 28 1112.9SELL, IL2, IL2RB, CD79A, MBL2
19cytidine44 11 2412.9ICOS, CD79A, CD40LG, AICDA
20rapamycin4410.9CD28, SELL, IL2, IL2RB, CD86, CD40LG
21thyroxine44 2411.9CD40LG, CD79A, IL4, MBL2, IL2RB
22herbimycin a44 5911.9CD28, SELL, CD40LG, IL4, IL2
23ribavirin44 49 1112.9IL4, IL2, MBL2, CD40LG
24lactose44 1111.9SELL, IL2RB, CD40LG, MBL2
25rituximab44 49 1112.9TNFSF13B, CD79A, CD40LG, IL2
26genistein44 28 59 2 11 2415.8CD28, IL2RB, SELL, CD40LG, IL2, BTK
27pentoxifylline44 1111.8IL2RB, SELL, IL4
28phosphatidylserine44 28 1112.8CD79A
29allergens4410.8CD79A, CD86, CD40LG, IL4
30daclizumab44 1111.8IL2RB, IL2, CD40LG
31tuberculin4410.8MBL2, CD40LG, CD79A
32aspirin44 49 28 2413.8IL4, IL2RB, SELL, CD79A, CD40LG
33praziquantel44 1111.8CD40LG, IL4, CD79A
34alemtuzumab44 1111.8CD40LG, IL2RB, IL2
35hemocyanin4410.8IL4, CD79A, CD40LG
36creatinine4410.8SELL, IL2RB, CD79A, CD40LG, TNFSF13B, MBL2
37vegf4410.8MBL2, IL2RB, CD79A, SELL
38azathioprine44 49 2 1113.8IL2, CD79A, IL2RB, IL4
39tyrosine4410.7IL2RB, CD86, BTK, IL2, CD28, IL4
40sulfolipid i4410.7CD40LG, CD79A
41r-il-24410.7IL2, IL2RB
42tdac4410.7IL2, IL4
43cycloheximide4410.7SELL, IL2RB
44polysaccharide4410.6CD79A, CD40LG, MBL2, SELL, IL2RB
45mannan4410.6CD40LG, CD79A, MBL2
46mycophenolic acid44 49 1112.6IL2RB, IL2, CD40LG
47cysteine4410.5BTK, CD40LG, CD27, CD28, IL4, CD79A
48sandoglobulin4410.5CD79A, CD40LG
49baff2810.4TNFRSF13B, TNFRSF13C
50fitc4410.2CD86, SELL, IL2RB

GO Terms for genes affiliated with Common Variable Immunodeficiency

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Sources:
16Gene Ontology
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Cellular components related to Common Variable Immunodeficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.5TNFSF13B, BTK, CD86, CD40LG, CD79A, CD28
2external side of plasma membraneGO:00989710.4SELL, ICOS, TNFRSF13C, TNFRSF13B, CD86, CD40LG
3integral to plasma membraneGO:00588710.2ICOS, TNFRSF13B, CD40LG, CD27, CD28, IL2RB

Biological processes related to Common Variable Immunodeficiency according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129510.8CD28, CD86, TNFSF13B, TNFRSF13C, ICOS
2B cell costimulationGO:03129610.8TNFRSF13C, TNFSF13B, IL4
3positive regulation of B cell proliferationGO:03089010.8IL2, IL4, TNFSF13B, TNFRSF13C
4positive regulation of T cell proliferationGO:04210210.7IL4, CD28, TNFSF13B, TNFRSF13C
5positive regulation of isotype switching to IgG isotypesGO:04830410.7CD28, IL4, IL2
6B cell differentiationGO:03018310.7AICDA, CD40LG, CD79A, IL4
7immune responseGO:00695510.7ICOS, VPREB1, TNFSF13B, CD86, IL4, IL2
8B cell homeostasisGO:00178210.7TNFRSF13B, TNFSF13B, TNFRSF13C
9B cell activationGO:04211310.7BTK, CD86, CD79A
10positive regulation of germinal center formationGO:00263610.6TNFSF13B, TNFRSF13C
11immunoglobulin secretionGO:04830510.6CD40LG, TNFSF13B
12negative regulation of apoptotic processGO:04306610.6CD40LG, CD27, IL4, IL2RB, IL2
13positive regulation of B cell differentiationGO:04557910.5CD27, BTK
14positive regulation of interleukin-2 biosynthetic processGO:04508610.5CD28, CD86
15B cell proliferationGO:04210010.4CD40LG, CD79A
16regulation of immune responseGO:05077610.2SELL, IL4, CD40LG

Molecular functions related to Common Variable Immunodeficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosphingolipid bindingGO:04320810.5SELL, IL2
2cytokine activityGO:00512510.2IL2, IL4, CD40LG, TNFSF13B

Products for genes affiliated with Common Variable Immunodeficiency

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  • Antibodies
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Sources for Common Variable Immunodeficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet