MCID: CMM003
MIFTS: 51

Common Wart malady

Infectious diseases, Skin diseases categories
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Summaries for Common Wart

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). this infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards: Common Wart is related to rubella and measles, and has symptoms including raised wart An important gene associated with Common Wart is NFIX (nuclear factor I/X (CCAAT-binding transcription factor)), and among its related pathways are RNA Polymerase III Transcription Initiation and EBV LMP1 signaling. The drugs cantharidin and formaldehyde and the compounds dpa 1 and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin and skin, and related mouse phenotypes are digestive/alimentary and skeleton.

Aliases & Classifications for Common Wart

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Aliases & Descriptions:

common wart 8 10 62


Related Diseases for Common Wart

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Common Wart via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1rubella10.2
2measles10.2
3mumps10.2
4chronic inflammatory demyelinating polyradiculoneuropathy10.1IFNB1
5malaria10.1HLA-DRB1
6narcolepsy10.1HLA-DRB1
7maturity-onset diabetes of the young10.1NFIC, NFIX
8neurofibroma10.1NFIC, NFIX
9neurofibromatosis10.1NFIX, NFIC
10multiple sclerosis 110.1HLA-DQB1, HLA-DRB1
11molluscum contagiosum10.0
12epidermodysplasia verruciformis10.0
13verrucous carcinoma10.0
14conjunctivitis10.0
15lymphedema10.0
16pulmonary tuberculosis10.0HLA-DQB1, HLA-DRB1
17celiac disease10.0HLA-DQB1, HLA-DQA1
18autoimmune hepatitis10.0HLA-DRB1, HLA-DQB1
19hepatitis b10.0HLA-DRB1, HLA-DQB1
20viral hepatitis10.0HLA-DQA1, HLA-DRB1, IFNB1
21hepatitis10.0IFNB1, HLA-DRB1
22skin disease10.0IL6, HLA-DRB1
23graves' disease10.0HLA-DRB1, HLA-DQA1, HLA-DQB1
24type 1 diabetes mellitus10.0HLA-DRB1, HLA-DQA1, HLA-DQB1
25tuberculosis10.0HLA-DQB1, HLA-DRB1, IFNB1
26kaposi's sarcoma10.0IL6, IFNB1
27viral meningitis10.0IL8, IL6
28chorioamnionitis10.0IL8, IL6
29adult respiratory distress syndrome10.0IL8, IL6
30newborn respiratory distress syndrome10.0IL6, IL8
31meningitis10.0IL6, IL8
32periodontitis10.0IL6, IL8
33monocytic leukemia10.0IFNB1, IL6, IL8
34hypersensitivity reaction type ii disease10.0IL6, HLA-DRB1, HLA-DQB1
35synovitis10.0IL6, IL8
36astrocytoma10.0TP53, IFNB1, IL6
37connective tissue disease10.0HLA-DRB1, IL6
38inflammatory bowel disease10.0IL8, IL6
39asthma10.0IFNB1, IL8, HLA-DRB1, HLA-DQA1
40vascular disease9.9IL8, TP53, IL6
41psoriasis9.9IL6, HLA-DRB1, IL8
42viral infectious disease9.9IL6, IL8, IFNB1
43melanoma9.9IL8, TP53, HLA-DRB1, IFNB1
44arthritis9.9IL6, HLA-DRB1, IL8
45juvenile rheumatoid arthritis9.9HLA-DRB1, HLA-DQA1, HLA-DQB1, IL6
46acute pancreatitis9.9IL6, IL8
47diabetes mellitus9.9IL6, HLA-DRB1, HLA-DQA1, HLA-DQB1
48hepatocellular carcinoma9.9IFNB1, HLA-DRB1, IL6, TP53
49ulcerative colitis9.9IL6, IL8, IFNB1, HLA-DRB1
50burkitt's lymphoma9.9HLA-DRB1, TP53, HLA-DQB1, IL6

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to common wart

Symptoms for Common Wart

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Sources:
8Disease Ontology
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Symptoms:

8
  • raised wart

Drugs & Therapeutics for Common Wart

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Common Wart

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Anatomical Context for Common Wart

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Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Common Wart:

33
Skin

FMA organs/tissues related to Common Wart:

14
Skin

Animal Models for Common Wart or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Common Wart:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0HLA-DQB1, TP53, IL6, NFIX
2MP:00053907.8TP53, IFNB1, IL6, NFIC, NFIX
3MP:00053867.8NFIX, NFIC, IL6, TP53, HLA-DQB1
4MP:00053977.5IL6, IL8, IFNB1, TP53, HLA-DQA1, HLA-DQB1
5MP:00053877.4HLA-DQB1, HLA-DQA1, TP53, IFNB1, IL8, IL6
6MP:00036317.3HLA-DQB1, TP53, IFNB1, IL6, NFIC, NFIX

Publications for Common Wart

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Sources:
52PubMed
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Articles related to Common Wart:

(show all 27)
idTitleAuthorsYear
1
Measles, mumps, and rubella vaccine: a new option to treat common warts? (23786798)
2013
2
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. (22277059)
2013
3
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. (23135096)
2012
4
Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine. (20202055)
2010
5
Treatment options for the common wart. (18210913)
2007
6
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. (17214114)
2006
7
Human leukocyte antigen class II alleles and natural history of HPV 2/27/57-induced common warts. (15257408)
2004
8
Molecular analysis of the effect of topical imiquimod treatment of HPV 2/27/57-induced common warts. (15452412)
2004
9
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). (12361440)
2002
10
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? (12361441)
2002
11
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. (11525958)
2001
12
Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. (11069514)
2000
13
Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. (8734914)
1996
14
Efficacious treatment of the common wart (verruca vulgaris). (1462533)
1992
15
Systemic treatment of common warts with beta-interferon]. (1917463)
1991
16
Characterization of two HPV-3 related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis. (6302170)
1983
17
An unusual transformation of a common wart in a child. (6269499)
1981
18
Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema. (7248909)
1981
19
Stump the experts. A common wart. (7338585)
1981
20
The common wart: intralesional treatment with bleomycin sulfate. (6159138)
1980
21
Treatment of the common wart by induced allergic inflammation. (7389963)
1980
22
Treatment of the common wart with a virus vaccine. (14477428)
1962
23
Morphological characterization of the virus of the human common wart (verruca vulgaris). (13785470)
1961
24
Aralen and plaquenil in treatment of the common wart. (13726985)
1961
25
Treatment of the common wart by x-ray therapy. (13164671)
1954
26
Common wart conjunctivitis. (13196997)
1954
27
Contact x-ray therapy of the common wart. (14914174)
1952

Variations for Common Wart

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Expression for genes affiliated with Common Wart

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Common Wart

Search GEO for disease gene expression data for Common Wart.

Pathways for genes affiliated with Common Wart

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 54R&D Systems, 57SinoBiological
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Pathways related to Common Wart according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6NFIX, NFIC
29.6IL8, IFNB1
39.5IFNB1, IL6
49.3IL8, IL6
59.3IL8, IL6
69.3IL8, IL6
79.3IL6, IL8
89.3IL6, IL8
9
Show member pathways
9.3IL6, IL8
109.3IL6, IL8
11
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.2HLA-DQB1, HLA-DRB1, HLA-DQA1
129.2HLA-DRB1, HLA-DQA1, HLA-DQB1
139.2HLA-DQB1, HLA-DQA1, HLA-DRB1
149.2HLA-DRB1, HLA-DQA1, HLA-DQB1
15
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.2HLA-DRB1, HLA-DQB1, HLA-DQA1
16
Show member pathways
9.2HLA-DRB1, HLA-DQA1, HLA-DQB1
17
Show member pathways
9.2HLA-DQB1, HLA-DRB1, HLA-DQA1
189.2HLA-DRB1, HLA-DQA1, HLA-DQB1
19
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
20
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
21
Show member pathways
9.2HLA-DQB1, HLA-DRB1, HLA-DQA1
22
Show member pathways
9.2HLA-DQA1, HLA-DRB1, HLA-DQB1
239.1HLA-DRB1, IFNB1, IL6
249.0IFNB1, IL6, IL8
25
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0IL8, IFNB1, IL6
26
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0IFNB1, IL8, IL6
27
Show member pathways
8.9TP53, HLA-DQA1, HLA-DQB1
288.8IL8, IFNB1, TP53
298.7IFNB1, IL6, TP53
30
Show member pathways
8.6IL6, HLA-DQB1, HLA-DQA1, HLA-DRB1
31
Show member pathways
8.6IL6, HLA-DRB1, HLA-DQA1, HLA-DQB1
328.5IL8, TP53, IL6
338.5IL6, TP53, IL8
348.5TP53, IL6, IL8
358.5IL6, IL8, TP53
36
Show member pathways
Immune response MIF in innate immunity response60
8.5TP53, IL8, IL6
37
Show member pathways
8.4HLA-DQB1, TP53, HLA-DRB1, HLA-DQA1
388.4HLA-DQA1, HLA-DQB1, HLA-DRB1, TP53
39
Show member pathways
8.4NFIC, NFIX, HLA-DRB1, HLA-DQA1, HLA-DQB1
408.3HLA-DQA1, IL6, IFNB1, HLA-DQB1, HLA-DRB1
41
Show member pathways
8.3IL6, HLA-DQB1, HLA-DQA1, HLA-DRB1, IFNB1
42
Show member pathways
8.2TP53, IL6, IL8, IFNB1
43
Show member pathways
8.2TP53, IL6, IL8, IFNB1
44
Show member pathways
8.2IFNB1, TP53, IL6, IL8
458.2IL8, IL6, IFNB1, TP53
46
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.2IL6, IL8, IFNB1, TP53
478.1HLA-DQB1, IL6, IL8, HLA-DRB1, HLA-DQA1
487.8TP53, HLA-DRB1, HLA-DQA1, IL6, HLA-DQB1
49
Show member pathways
7.8HLA-DQA1, HLA-DRB1, TP53, IL6, HLA-DQB1
50
Show member pathways
6.9TP53, HLA-DRB1, IL6, IL8, IFNB1, HLA-DQA1

Compounds for genes affiliated with Common Wart

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Common Wart according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1dpa 14510.1HLA-DQA1, HLA-DRB1
2glatiramer acetate45 1110.9IFNB1, HLA-DRB1
3lapatinib45 51 1111.9HLA-DRB1, HLA-DQA1
4flagellin45 2910.8IFNB1, IL8
5emedastine45 1110.8IL6, IL8
6gold sodium thiomalate459.8IL8, HLA-DRB1
7tepoxalin459.7IL8, IL6
8sivelestat459.7IL6, IL8
9rebamipide459.7IL6, IL8
10taurine chloramine459.7IL8, IL6
11olopatadine45 1110.7IL8, IL6
12acnu459.7TP53, IFNB1
13gabexate mesilate459.7IL8, IL6
14ulinastatin459.7IL8, IL6
15mcp 1459.7IL8, IL6
16hbd2459.7IL8, IL6
17u0126459.7IL8, IL6
18mip 1alpha459.6IL8, IL6
19hpvs459.6TP53, IFNB1
20il-12459.5IL8, IL6
21hcec459.4IL6, IL8, IFNB1
22imiquimod45 61 29 1112.4IL6, IL8, IFNB1
23lipoteichoic acid459.4IL6, IL8, IFNB1
24polyinosinic-polycytidylic acid459.4IFNB1, IL8, IL6
25poly(i-c)459.4IFNB1, IL8, IL6
26il 10459.4IL6, IL8, IFNB1
27peptidoglycan45 2910.4IL6, IL8, IFNB1
28ccl345 2910.4IFNB1, IL8, IL6
29neopterin459.4IL6, IL8, IFNB1
30temozolomide45 1110.4IFNB1, TP53
31herbimycin a45 6110.3IL6, IL8, IFNB1
32simvastatin45 51 61 29 24 1114.3IL6, IL8, IFNB1
33tpck459.3IL8, IL6
34groalpha459.3IL6, IL8
35endotoxin459.3IFNB1, IL8, IL6
36methotrexate51 45 1111.3HLA-DRB1, IFNB1, IL6
37rantes459.1IL6, IL8, IFNB1
38polymyxin b459.0IL6, IL8
39triptolide459.0TP53, IL8, IL6
40parthenolide45 310.0IL6, IL8, TP53
41pdtc458.9TP53, IL8, IL6
42sp 60012545 619.9IL6, IL8, TP53
43curcumin458.8IL6, IL8, TP53
44sb 20358045 619.6TP53, IFNB1, IL8, IL6
45ly294002458.6TP53, IFNB1, IL8, IL6
46actinomycin d458.6IL6, IL8, IFNB1, TP53
47cycloheximide458.5IL6, IL8, IFNB1, TP53
48oligonucleotide458.5IFNB1, TP53, HLA-DRB1, HLA-DQA1, HLA-DQB1
49n acetylcysteine458.4IL6, IL8, TP53
50vegf458.4IL6, IL8, IFNB1, TP53

GO Terms for genes affiliated with Common Wart

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Sources:
16Gene Ontology
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Cellular components related to Common Wart according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.4HLA-DRB1, HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.4HLA-DRB1, HLA-DQA1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DQB1, HLA-DQA1, HLA-DRB1
4transport vesicle membraneGO:0306589.3HLA-DRB1, HLA-DQA1, HLA-DQB1
5ER to Golgi transport vesicle membraneGO:0125079.2HLA-DQB1, HLA-DQA1, HLA-DRB1
6lysosomal membraneGO:0057659.2HLA-DRB1, HLA-DQA1, HLA-DQB1
7trans-Golgi network membraneGO:0325889.1HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.9HLA-DQB1, HLA-DQA1, HLA-DRB1

Biological processes related to Common Wart according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DQB1, HLA-DRB1
3humoral immune responseGO:0069599.5IL6, IFNB1
4interferon-gamma-mediated signaling pathwayGO:0603339.5HLA-DRB1, HLA-DQA1, HLA-DQB1
5T cell costimulationGO:0312959.5HLA-DQB1, HLA-DQA1, HLA-DRB1
6T cell receptor signaling pathwayGO:0508529.4HLA-DQB1, HLA-DQA1, HLA-DRB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.3HLA-DRB1, HLA-DQA1, HLA-DQB1
8protein tetramerizationGO:0512629.2TP53, HLA-DRB1
9response to antibioticGO:0466778.9IL6, TP53
10immune responseGO:0069558.9HLA-DQB1, HLA-DQA1, HLA-DRB1, IL8
11cytokine-mediated signaling pathwayGO:0192218.5IL6, IFNB1, HLA-DRB1, HLA-DQA1, HLA-DQB1
12negative regulation of cell proliferationGO:0082858.2TP53, IL8, IL6
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.1TP53, IFNB1, IL6, NFIC, NFIX

Molecular functions related to Common Wart according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.2HLA-DRB1, HLA-DQA1, HLA-DQB1

Products for genes affiliated with Common Wart

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Wart

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet