MCID: CMM003
MIFTS: 38

Common Wart malady

Skin diseases category

Summaries for Common Wart

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Disease Ontology:9 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). this infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards based summary: Common Wart is related to chronic inflammatory demyelinating polyradiculoneuropathy and malaria, and has symptoms including raised wart An important gene associated with Common Wart is NFIX (nuclear factor I/X (CCAAT-binding transcription factor)), and among its related pathways are RNA Polymerase III Transcription Initiation and EBV LMP1 signaling. The compounds dpa 1 and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin and skin, and related mouse phenotypes are digestive/alimentary and skeleton.

Aliases & Classifications for Common Wart

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Common Wart, Aliases & Descriptions:

Name: Common Wart 9 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Common Wart

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Diseases related to Common Wart via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1chronic inflammatory demyelinating polyradiculoneuropathy10.5IFNB1
2malaria10.4HLA-DRB1
3narcolepsy10.4HLA-DRB1
4maturity-onset diabetes of the young10.3NFIC, NFIX
5neurofibroma10.3NFIC, NFIX
6neurofibromatosis10.3NFIX, NFIC
7multiple sclerosis, disease progression, modifier of10.2HLA-DQB1, HLA-DRB1
8rubella10.2
9measles10.2
10mumps10.2
11pulmonary tuberculosis10.2HLA-DQB1, HLA-DRB1
12celiac disease10.2HLA-DQB1, HLA-DQA1
13autoimmune hepatitis10.2HLA-DRB1, HLA-DQB1
14hepatitis b10.1HLA-DRB1, HLA-DQB1
15viral hepatitis10.1HLA-DQA1, HLA-DRB1, IFNB1
16hepatitis10.1IFNB1, HLA-DRB1
17epidermodysplasia verruciformis10.1
18lymphedema10.1
19molluscum contagiosum10.1
20verrucous carcinoma10.1
21conjunctivitis10.1
22skin disease10.1IL6, HLA-DRB1
23graves' disease10.1HLA-DRB1, HLA-DQA1, HLA-DQB1
24diabetes mellitus, insulin-dependent10.0HLA-DRB1, HLA-DQA1, HLA-DQB1
25tuberculosis10.0HLA-DQB1, HLA-DRB1, IFNB1
26kaposi sarcoma10.0IL6, IFNB1
27viral meningitis10.0IL8, IL6
28chorioamnionitis10.0IL8, IL6
29acute respiratory distress syndrome10.0IL8, IL6
30meningitis9.9IL6, IL8
31periodontitis9.9IL6, IL8
32monocytic leukemia9.9IFNB1, IL6, IL8
33hypersensitivity reaction type ii disease9.9IL6, HLA-DRB1, HLA-DQB1
34synovitis9.9IL6, IL8
35astrocytoma9.8TP53, IFNB1, IL6
36connective tissue disease9.8HLA-DRB1, IL6
37inflammatory bowel disease9.8IL8, IL6
38asthma9.8IFNB1, IL8, HLA-DRB1, HLA-DQA1
39vascular disease9.8IL8, TP53, IL6
40psoriasis9.7IL6, HLA-DRB1, IL8
41viral infectious disease9.7IL6, IL8, IFNB1
42melanoma9.7IL8, TP53, HLA-DRB1, IFNB1
43arthritis9.7IL6, HLA-DRB1, IL8
44juvenile rheumatoid arthritis9.7HLA-DRB1, HLA-DQA1, HLA-DQB1, IL6
45acute pancreatitis9.7IL6, IL8
46hepatocellular carcinoma9.7IFNB1, HLA-DRB1, IL6, TP53
47ulcerative colitis9.6IL6, IL8, IFNB1, HLA-DRB1
48burkitt lymphoma9.6HLA-DRB1, TP53, HLA-DQB1, IL6
49leukemia9.6HLA-DRB1, IL6, IFNB1, TP53
50systemic lupus erythematosus9.6IFNB1, HLA-DRB1, HLA-DQA1, HLA-DQB1, IL6

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to common wart

Symptoms for Common Wart

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Symptoms:

 9
  • raised wart

Drugs & Therapeutics for Common Wart

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Drug clinical trials:

Search ClinicalTrials for Common Wart

Search NIH Clinical Center for Common Wart

Genetic Tests for Common Wart

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Anatomical Context for Common Wart

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MalaCards organs/tissues related to Common Wart:

31
Skin

FMA organs/tissues related to Common Wart:

14
Skin

Animal Models for Common Wart or affiliated genes

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MGI Mouse Phenotypes related to Common Wart:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0HLA-DQB1, TP53, IL6, NFIX
2MP:00053907.8TP53, IFNB1, IL6, NFIC, NFIX
3MP:00053867.8NFIX, NFIC, IL6, TP53, HLA-DQB1
4MP:00053977.5IL6, IL8, IFNB1, TP53, HLA-DQA1, HLA-DQB1
5MP:00053877.4HLA-DQB1, HLA-DQA1, TP53, IFNB1, IL8, IL6
6MP:00036317.3HLA-DQB1, TP53, IFNB1, IL6, NFIC, NFIX

Publications for Common Wart

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Articles related to Common Wart:

(show all 27)
idTitleAuthorsYear
1
Measles, mumps, and rubella vaccine: a new option to treat common warts? (23786798)
2013
2
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. (22277059)
2013
3
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. (23135096)
2012
4
Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine. (20202055)
2010
5
Treatment options for the common wart. (18210913)
2007
6
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. (17214114)
2006
7
Human leukocyte antigen class II alleles and natural history of HPV 2/27/57-induced common warts. (15257408)
2004
8
Molecular analysis of the effect of topical imiquimod treatment of HPV 2/27/57-induced common warts. (15452412)
2004
9
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). (12361440)
2002
10
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? (12361441)
2002
11
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. (11525958)
2001
12
Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. (11069514)
2000
13
Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. (8734914)
1996
14
Efficacious treatment of the common wart (verruca vulgaris). (1462533)
1992
15
Systemic treatment of common warts with beta-interferon]. (1917463)
1991
16
Characterization of two HPV-3 related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis. (6302170)
1983
17
An unusual transformation of a common wart in a child. (6269499)
1981
18
Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema. (7248909)
1981
19
Stump the experts. A common wart. (7338585)
1981
20
The common wart: intralesional treatment with bleomycin sulfate. (6159138)
1980
21
Treatment of the common wart by induced allergic inflammation. (7389963)
1980
22
Treatment of the common wart with a virus vaccine. (14477428)
1962
23
Morphological characterization of the virus of the human common wart (verruca vulgaris). (13785470)
1961
24
Aralen and plaquenil in treatment of the common wart. (13726985)
1961
25
Treatment of the common wart by x-ray therapy. (13164671)
1954
26
Common wart conjunctivitis. (13196997)
1954
27
Contact x-ray therapy of the common wart. (14914174)
1952

Variations for Common Wart

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Expression for genes affiliated with Common Wart

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Search GEO for disease gene expression data for Common Wart.

Pathways for genes affiliated with Common Wart

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Pathways related to Common Wart according to GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6NFIX, NFIC
29.6IL8, IFNB1
39.5IL6, IFNB1
49.3IL6, IL8
59.3IL6, IL8
69.3IL8, IL6
79.3IL6, IL8
89.3IL6, IL8
9
Show member pathways
9.3IL6, IL8
109.3IL6, IL8
11
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
12
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
139.2HLA-DQB1, HLA-DQA1, HLA-DRB1
14
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
159.2HLA-DQB1, HLA-DQA1, HLA-DRB1
16
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
17
Show member pathways
9.2HLA-DRB1, HLA-DQA1, HLA-DQB1
189.2HLA-DQB1, HLA-DQA1, HLA-DRB1
199.2HLA-DQB1, HLA-DQA1, HLA-DRB1
20
Show member pathways
9.2HLA-DRB1, HLA-DQA1, HLA-DQB1
21
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
22
Show member pathways
9.2HLA-DRB1, HLA-DQA1, HLA-DQB1
239.1IL6, IFNB1, HLA-DRB1
249.0IL6, IL8, IFNB1
25
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.0IL6, IL8, IFNB1
26
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0IL6, IL8, IFNB1
27
Show member pathways
8.9HLA-DQB1, HLA-DQA1, TP53
288.8IL8, IFNB1, TP53
298.7IL6, IFNB1, TP53
30
Show member pathways
8.6HLA-DQB1, HLA-DQA1, HLA-DRB1, IL6
31
Show member pathways
8.6HLA-DQB1, HLA-DQA1, HLA-DRB1, IL6
328.5TP53, IL8, IL6
338.5TP53, IL8, IL6
348.5IL6, IL8, TP53
358.5TP53, IL8, IL6
36
Show member pathways
Immune response MIF in innate immunity response58
8.5IL6, IL8, TP53
37
Show member pathways
8.4TP53, HLA-DRB1, HLA-DQA1, HLA-DQB1
388.4HLA-DQB1, HLA-DQA1, HLA-DRB1, TP53
39
Show member pathways
8.4HLA-DQB1, HLA-DQA1, HLA-DRB1, NFIC, NFIX
408.3IL6, IFNB1, HLA-DRB1, HLA-DQA1, HLA-DQB1
41
Show member pathways
8.3IL6, IFNB1, HLA-DRB1, HLA-DQA1, HLA-DQB1
428.2TP53, IFNB1, IL8, IL6
43
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.2TP53, IFNB1, IL8, IL6
44
Show member pathways
8.2TP53, IFNB1, IL8, IL6
45
Show member pathways
8.2IL6, IL8, IFNB1, TP53
46
Show member pathways
8.2IL6, IL8, IFNB1, TP53
478.1HLA-DQB1, HLA-DQA1, HLA-DRB1, IL8, IL6
48
Show member pathways
7.8HLA-DQB1, HLA-DQA1, HLA-DRB1, TP53, IL6
497.8HLA-DQB1, HLA-DQA1, HLA-DRB1, TP53, IL6
50
Show member pathways
6.9IL6, IL8, IFNB1, TP53, HLA-DRB1, HLA-DQA1

Compounds for genes affiliated with Common Wart

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Compounds related to Common Wart according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1dpa 14310.1HLA-DQA1, HLA-DRB1
2glatiramer acetate43 1210.9HLA-DRB1, IFNB1
3lapatinib43 49 1211.9HLA-DQA1, HLA-DRB1
4gold sodium thiomalate439.8HLA-DRB1, IL8
5emedastine43 1210.8IL6, IL8
6flagellin43 2810.8IL8, IFNB1
7tepoxalin439.8IL8, IL6
8sivelestat439.7IL8, IL6
9rebamipide439.7IL8, IL6
10olopatadine43 1210.7IL8, IL6
11taurine chloramine439.7IL8, IL6
12acnu439.7IFNB1, TP53
13gabexate mesilate439.7IL6, IL8
14ulinastatin439.7IL8, IL6
15hbd2439.7IL6, IL8
16mcp 1439.7IL8, IL6
17u0126439.7IL8, IL6
18mip 1alpha439.6IL6, IL8
19hpvs439.6TP53, IFNB1
20il-12439.5IL6, IL8
21hcec439.4IFNB1, IL8, IL6
22imiquimod43 59 28 1212.4IL8, IL6, IFNB1
23lipoteichoic acid439.4IL6, IL8, IFNB1
24polyinosinic-polycytidylic acid439.4IFNB1, IL8, IL6
25poly(i-c)439.4IL6, IL8, IFNB1
26il 10439.4IFNB1, IL6, IL8
27peptidoglycan43 2810.4IL8, IFNB1, IL6
28ccl343 2810.4IL8, IFNB1, IL6
29neopterin439.4IFNB1, IL8, IL6
30temozolomide43 1210.4TP53, IFNB1
31herbimycin a43 5910.3IFNB1, IL8, IL6
32simvastatin43 49 59 28 24 1214.3IFNB1, IL6, IL8
33tpck439.3IL8, IL6
34groalpha439.3IL8, IL6
35endotoxin439.3IL6, IFNB1, IL8
36methotrexate49 43 1211.3IFNB1, HLA-DRB1, IL6
37rantes439.1IL8, IL6, IFNB1
38polymyxin b439.0IL6, IL8
39triptolide439.0IL6, IL8, TP53
40parthenolide43 210.0IL8, TP53, IL6
41pdtc438.9IL6, IL8, TP53
42sp 60012543 599.9TP53, IL8, IL6
43curcumin438.8IL6, IL8, TP53
44sb 20358043 599.6IFNB1, IL6, IL8, TP53
45ly294002438.6IL8, TP53, IFNB1, IL6
46actinomycin d438.6IFNB1, IL6, IL8, TP53
47cycloheximide438.5IL6, IFNB1, IL8, TP53
48oligonucleotide438.5IFNB1, HLA-DRB1, HLA-DQA1, TP53, HLA-DQB1
49n acetylcysteine438.4IL6, TP53, IL8
50vegf438.4IL8, IFNB1, IL6, TP53

GO Terms for genes affiliated with Common Wart

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Cellular components related to Common Wart according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.4HLA-DRB1, HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-DRB1, HLA-DQA1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:00306699.3HLA-DQB1, HLA-DQA1, HLA-DRB1
4transport vesicle membraneGO:00306589.3HLA-DRB1, HLA-DQA1, HLA-DQB1
5ER to Golgi transport vesicle membraneGO:00125079.2HLA-DQB1, HLA-DQA1, HLA-DRB1
6lysosomal membraneGO:00057659.2HLA-DRB1, HLA-DQA1, HLA-DQB1
7trans-Golgi network membraneGO:00325889.1HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:00306668.9HLA-DQB1, HLA-DQA1, HLA-DRB1

Biological processes related to Common Wart according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.8HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00024559.7HLA-DQB1, HLA-DRB1
3humoral immune responseGO:00069599.5IFNB1, IL6
4interferon-gamma-mediated signaling pathwayGO:00603339.5HLA-DQB1, HLA-DRB1, HLA-DQA1
5T cell costimulationGO:00312959.5HLA-DQB1, HLA-DQA1, HLA-DRB1
6T cell receptor signaling pathwayGO:00508529.4HLA-DQB1, HLA-DQA1, HLA-DRB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.3HLA-DQB1, HLA-DQA1, HLA-DRB1
8protein tetramerizationGO:00512629.2HLA-DRB1, TP53
9response to antibioticGO:00466778.9IL6, TP53
10immune responseGO:00069558.9HLA-DQB1, HLA-DQA1, HLA-DRB1, IL8
11cytokine-mediated signaling pathwayGO:00192218.5IFNB1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL6
12negative regulation of cell proliferationGO:00082858.2TP53, IL8, IL6
13positive regulation of transcription from RNA polymerase II promoterGO:00459448.1IFNB1, NFIX, NFIC, TP53, IL6

Molecular functions related to Common Wart according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.2HLA-DRB1, HLA-DQA1, HLA-DQB1

Products for genes affiliated with Common Wart

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  • Antibodies
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  • Lysates
  • Antibodies
  • Proteins
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Sources for Common Wart

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet