MCID: CMM003
MIFTS: 50

Common Wart malady

Infectious diseases, Skin diseases categories

Summaries for Common Wart

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Disease Ontology:9 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). this infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards based summary: Common Wart is related to chronic inflammatory demyelinating polyneuropathy and malaria, and has symptoms including raised wart An important gene associated with Common Wart is NFIX (nuclear factor I/X (CCAAT-binding transcription factor)), and among its related pathways are RNA Polymerase III Transcription Initiation and EBV LMP1 signaling. The drugs cantharidin and formaldehyde and the compounds dpa 1 and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include skin and skin, and related mouse phenotypes are digestive/alimentary and skeleton.

Aliases & Classifications for Common Wart

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Common Wart, Aliases & Descriptions:

Name: Common Wart 9 11 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Related Diseases for Common Wart

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Diseases related to Common Wart via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1chronic inflammatory demyelinating polyneuropathy10.5IFNB1
2malaria10.4HLA-DRB1
3narcolepsy10.4HLA-DRB1
4maturity-onset diabetes of the young10.3NFIC, NFIX
5neurofibroma10.3NFIC, NFIX
6neurofibromatosis10.3NFIX, NFIC
7multiple sclerosis 110.2HLA-DQB1, HLA-DRB1
8mumps10.2
9rubella10.2
10measles10.2
11pulmonary tuberculosis10.2HLA-DQB1, HLA-DRB1
12celiac disease10.2HLA-DQB1, HLA-DQA1
13autoimmune hepatitis10.2HLA-DRB1, HLA-DQB1
14hepatitis b10.2HLA-DRB1, HLA-DQB1
15viral hepatitis10.1HLA-DQA1, HLA-DRB1, IFNB1
16hepatitis10.1IFNB1, HLA-DRB1
17skin disease10.1IL6, HLA-DRB1
18lymphedema10.1
19epidermodysplasia verruciformis10.1
20molluscum contagiosum10.1
21verrucous carcinoma10.1
22conjunctivitis10.1
23graves' disease10.1HLA-DRB1, HLA-DQA1, HLA-DQB1
24type 1 diabetes mellitus10.1HLA-DRB1, HLA-DQA1, HLA-DQB1
25tuberculosis10.0HLA-DQB1, HLA-DRB1, IFNB1
26kaposi's sarcoma10.0IL6, IFNB1
27viral meningitis10.0IL8, IL6
28chorioamnionitis10.0IL8, IL6
29adult respiratory distress syndrome10.0IL8, IL6
30meningitis9.9IL6, IL8
31periodontitis9.9IL6, IL8
32monocytic leukemia9.9IFNB1, IL6, IL8
33hypersensitivity reaction type ii disease9.9IL6, HLA-DRB1, HLA-DQB1
34synovitis9.9IL6, IL8
35astrocytoma9.9TP53, IFNB1, IL6
36connective tissue disease9.8HLA-DRB1, IL6
37inflammatory bowel disease9.8IL8, IL6
38asthma9.8IFNB1, IL8, HLA-DRB1, HLA-DQA1
39vascular disease9.8IL8, TP53, IL6
40psoriasis9.7IL6, HLA-DRB1, IL8
41viral infectious disease9.7IL6, IL8, IFNB1
42melanoma9.7IL8, TP53, HLA-DRB1, IFNB1
43arthritis9.7IL6, HLA-DRB1, IL8
44juvenile rheumatoid arthritis9.7HLA-DRB1, HLA-DQA1, HLA-DQB1, IL6
45acute pancreatitis9.7IL6, IL8
46diabetes mellitus9.7IL6, HLA-DRB1, HLA-DQA1, HLA-DQB1
47liver cancer9.7IFNB1, HLA-DRB1, IL6, TP53
48ulcerative colitis9.7IL6, IL8, IFNB1, HLA-DRB1
49burkitt's lymphoma9.6HLA-DRB1, TP53, HLA-DQB1, IL6
50leukemia9.6HLA-DRB1, IL6, IFNB1, TP53

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to common wart

Symptoms for Common Wart

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Symptoms:

 9
  • raised wart

Drugs & Therapeutics for Common Wart

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Genetic Tests for Common Wart

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Anatomical Context for Common Wart

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MalaCards organs/tissues related to Common Wart:

32
Skin

FMA organs/tissues related to Common Wart:

15
Skin

Animal Models for Common Wart or affiliated genes

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MGI Mouse Phenotypes related to Common Wart:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0HLA-DQB1, TP53, IL6, NFIX
2MP:00053907.8TP53, IFNB1, IL6, NFIC, NFIX
3MP:00053867.8NFIX, NFIC, IL6, TP53, HLA-DQB1
4MP:00053977.5IL6, IL8, IFNB1, TP53, HLA-DQA1, HLA-DQB1
5MP:00053877.4HLA-DQB1, HLA-DQA1, TP53, IFNB1, IL8, IL6
6MP:00036317.3HLA-DQB1, TP53, IFNB1, IL6, NFIC, NFIX

Publications for Common Wart

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Articles related to Common Wart:

(show all 27)
idTitleAuthorsYear
1
Measles, mumps, and rubella vaccine: a new option to treat common warts? (23786798)
2013
2
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. (22277059)
2013
3
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. (23135096)
2012
4
Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine. (20202055)
2010
5
Treatment options for the common wart. (18210913)
2007
6
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. (17214114)
2006
7
Human leukocyte antigen class II alleles and natural history of HPV 2/27/57-induced common warts. (15257408)
2004
8
Molecular analysis of the effect of topical imiquimod treatment of HPV 2/27/57-induced common warts. (15452412)
2004
9
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). (12361440)
2002
10
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? (12361441)
2002
11
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. (11525958)
2001
12
Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. (11069514)
2000
13
Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. (8734914)
1996
14
Efficacious treatment of the common wart (verruca vulgaris). (1462533)
1992
15
Systemic treatment of common warts with beta-interferon]. (1917463)
1991
16
Characterization of two HPV-3 related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis. (6302170)
1983
17
An unusual transformation of a common wart in a child. (6269499)
1981
18
Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema. (7248909)
1981
19
Stump the experts. A common wart. (7338585)
1981
20
The common wart: intralesional treatment with bleomycin sulfate. (6159138)
1980
21
Treatment of the common wart by induced allergic inflammation. (7389963)
1980
22
Treatment of the common wart with a virus vaccine. (14477428)
1962
23
Morphological characterization of the virus of the human common wart (verruca vulgaris). (13785470)
1961
24
Aralen and plaquenil in treatment of the common wart. (13726985)
1961
25
Treatment of the common wart by x-ray therapy. (13164671)
1954
26
Common wart conjunctivitis. (13196997)
1954
27
Contact x-ray therapy of the common wart. (14914174)
1952

Variations for Common Wart

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Expression for genes affiliated with Common Wart

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Expression patterns in normal tissues for genes affiliated with Common Wart

Search GEO for disease gene expression data for Common Wart.

Pathways for genes affiliated with Common Wart

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Pathways related to Common Wart according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6NFIX, NFIC
29.6IL8, IFNB1
39.5IFNB1, IL6
49.3IL8, IL6
59.3IL8, IL6
69.3IL8, IL6
79.3IL6, IL8
89.3IL6, IL8
9
Show member pathways
9.3IL6, IL8
109.3IL6, IL8
11
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
9.2HLA-DQB1, HLA-DRB1, HLA-DQA1
129.2HLA-DRB1, HLA-DQA1, HLA-DQB1
139.2HLA-DQB1, HLA-DQA1, HLA-DRB1
149.2HLA-DRB1, HLA-DQA1, HLA-DQB1
15
Show member pathways
Immune response T cell receptor signaling pathway59
Immune response CD28 signaling59
Immune response ICOS pathway in T helper cell59
9.2HLA-DRB1, HLA-DQB1, HLA-DQA1
16
Show member pathways
9.2HLA-DRB1, HLA-DQA1, HLA-DQB1
17
Show member pathways
9.2HLA-DQB1, HLA-DRB1, HLA-DQA1
189.2HLA-DRB1, HLA-DQA1, HLA-DQB1
19
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
20
Show member pathways
9.2HLA-DQB1, HLA-DQA1, HLA-DRB1
21
Show member pathways
9.2HLA-DQB1, HLA-DRB1, HLA-DQA1
22
Show member pathways
9.2HLA-DQA1, HLA-DRB1, HLA-DQB1
239.1HLA-DRB1, IFNB1, IL6
249.0IFNB1, IL6, IL8
25
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.0IL8, IFNB1, IL6
26
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.0IFNB1, IL8, IL6
27
Show member pathways
8.9TP53, HLA-DQA1, HLA-DQB1
288.8IL8, IFNB1, TP53
298.7IFNB1, IL6, TP53
30
Show member pathways
8.6IL6, HLA-DQB1, HLA-DQA1, HLA-DRB1
31
Show member pathways
8.6IL6, HLA-DRB1, HLA-DQA1, HLA-DQB1
328.5IL8, TP53, IL6
338.5IL6, TP53, IL8
348.5TP53, IL6, IL8
358.5IL6, IL8, TP53
36
Show member pathways
Immune response MIF in innate immunity response59
8.5TP53, IL8, IL6
37
Show member pathways
8.4HLA-DQB1, TP53, HLA-DRB1, HLA-DQA1
388.4HLA-DQA1, HLA-DQB1, HLA-DRB1, TP53
39
Show member pathways
8.4NFIC, NFIX, HLA-DRB1, HLA-DQA1, HLA-DQB1
408.3HLA-DQA1, IL6, IFNB1, HLA-DQB1, HLA-DRB1
41
Show member pathways
8.3IL6, HLA-DQB1, HLA-DQA1, HLA-DRB1, IFNB1
42
Show member pathways
8.2TP53, IL6, IL8, IFNB1
43
Show member pathways
8.2TP53, IL6, IL8, IFNB1
44
Show member pathways
8.2IFNB1, TP53, IL6, IL8
458.2IL8, IL6, IFNB1, TP53
46
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.2IL6, IL8, IFNB1, TP53
478.1HLA-DQB1, IL6, IL8, HLA-DRB1, HLA-DQA1
487.8TP53, HLA-DRB1, HLA-DQA1, IL6, HLA-DQB1
49
Show member pathways
7.8HLA-DQA1, HLA-DRB1, TP53, IL6, HLA-DQB1
50
Show member pathways
6.9TP53, HLA-DRB1, IL6, IL8, IFNB1, HLA-DQA1

Compounds for genes affiliated with Common Wart

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Compounds related to Common Wart according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1dpa 14410.1HLA-DQA1, HLA-DRB1
2glatiramer acetate44 1210.9IFNB1, HLA-DRB1
3lapatinib44 50 1211.9HLA-DRB1, HLA-DQA1
4flagellin44 2910.8IFNB1, IL8
5emedastine44 1210.8IL6, IL8
6gold sodium thiomalate449.8IL8, HLA-DRB1
7tepoxalin449.7IL8, IL6
8sivelestat449.7IL6, IL8
9rebamipide449.7IL6, IL8
10taurine chloramine449.7IL8, IL6
11olopatadine44 1210.7IL8, IL6
12acnu449.7TP53, IFNB1
13gabexate mesilate449.7IL8, IL6
14ulinastatin449.7IL8, IL6
15mcp 1449.7IL8, IL6
16hbd2449.7IL8, IL6
17u0126449.7IL8, IL6
18mip 1alpha449.6IL8, IL6
19hpvs449.6TP53, IFNB1
20il-12449.5IL8, IL6
21hcec449.4IL6, IL8, IFNB1
22imiquimod44 60 29 1212.4IL6, IL8, IFNB1
23lipoteichoic acid449.4IL6, IL8, IFNB1
24polyinosinic-polycytidylic acid449.4IFNB1, IL8, IL6
25poly(i-c)449.4IFNB1, IL8, IL6
26il 10449.4IL6, IL8, IFNB1
27peptidoglycan44 2910.4IL6, IL8, IFNB1
28ccl344 2910.4IFNB1, IL8, IL6
29neopterin449.4IL6, IL8, IFNB1
30temozolomide44 1210.4IFNB1, TP53
31herbimycin a44 6010.3IL6, IL8, IFNB1
32simvastatin44 50 60 29 25 1214.3IL6, IL8, IFNB1
33tpck449.3IL8, IL6
34groalpha449.3IL6, IL8
35endotoxin449.3IFNB1, IL8, IL6
36methotrexate50 44 1211.3HLA-DRB1, IFNB1, IL6
37rantes449.1IL6, IL8, IFNB1
38polymyxin b449.0IL6, IL8
39triptolide449.0TP53, IL8, IL6
40parthenolide44 310.0IL6, IL8, TP53
41pdtc448.9TP53, IL8, IL6
42sp 60012544 609.9IL6, IL8, TP53
43curcumin448.8IL6, IL8, TP53
44sb 20358044 609.6TP53, IFNB1, IL8, IL6
45ly294002448.6TP53, IFNB1, IL8, IL6
46actinomycin d448.6IL6, IL8, IFNB1, TP53
47cycloheximide448.5IL6, IL8, IFNB1, TP53
48oligonucleotide448.5IFNB1, TP53, HLA-DRB1, HLA-DQA1, HLA-DQB1
49n acetylcysteine448.4IL6, IL8, TP53
50vegf448.4IL6, IL8, IFNB1, TP53

GO Terms for genes affiliated with Common Wart

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Cellular components related to Common Wart according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.4HLA-DRB1, HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.4HLA-DRB1, HLA-DQA1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DQB1, HLA-DQA1, HLA-DRB1
4transport vesicle membraneGO:0306589.3HLA-DRB1, HLA-DQA1, HLA-DQB1
5ER to Golgi transport vesicle membraneGO:0125079.2HLA-DQB1, HLA-DQA1, HLA-DRB1
6lysosomal membraneGO:0057659.2HLA-DRB1, HLA-DQA1, HLA-DQB1
7trans-Golgi network membraneGO:0325889.1HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.9HLA-DQB1, HLA-DQA1, HLA-DRB1

Biological processes related to Common Wart according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DQB1, HLA-DRB1
3humoral immune responseGO:0069599.5IFNB1, IL6
4interferon-gamma-mediated signaling pathwayGO:0603339.5HLA-DQB1, HLA-DRB1, HLA-DQA1
5T cell costimulationGO:0312959.5HLA-DQB1, HLA-DQA1, HLA-DRB1
6T cell receptor signaling pathwayGO:0508529.4HLA-DQB1, HLA-DQA1, HLA-DRB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.3HLA-DQB1, HLA-DQA1, HLA-DRB1
8protein tetramerizationGO:0512629.2HLA-DRB1, TP53
9response to antibioticGO:0466778.9IL6, TP53
10immune responseGO:0069558.9HLA-DQB1, HLA-DQA1, HLA-DRB1, IL8
11cytokine-mediated signaling pathwayGO:0192218.5IFNB1, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL6
12negative regulation of cell proliferationGO:0082858.2TP53, IL8, IL6
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.1IFNB1, NFIX, NFIC, TP53, IL6

Molecular functions related to Common Wart according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.2HLA-DRB1, HLA-DQA1, HLA-DQB1

Products for genes affiliated with Common Wart

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  • Antibodies
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  • Proteins
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Sources for Common Wart

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet