MCID: CMM003
MIFTS: 44

Common Wart malady

Summaries for Common Wart

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). this infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards: Common Wart is related to measles and rubella, and has symptoms including raised wart An important gene associated with Common Wart is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are Cytokines and Inflammatory Response and Immune response MIF-mediated glucocorticoid regulation. The drugs interferon alfa-2a and interferon alfa-2b and the compounds dpa 1 and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include skin and skin, and related mouse phenotypes are nervous system and skeleton.

Aliases & Classifications for Common Wart

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Aliases & Descriptions:

common wart 8 10 61


Related Diseases for Common Wart

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Common Wart via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1measles30.2IFNB1
2rubella10.2
3mumps10.2
4molluscum contagiosum10.0
5verrucous carcinoma10.0
6plantar wart10.0
7epidermodysplasia verruciformis10.0
8squamous cell carcinoma10.0
9neutropenia10.0IFNB1
10neuromyelitis optica10.0IFNB1
11influenza10.0IFNB1
12optic neuritis10.0IFNB1
13myocarditis10.0IFNB1
14atopy10.0HLA-DQA1
15progressive multifocal leukoencephalopathy10.0IFNB1
16hepatitis10.0IFNB1
17myasthenia gravis10.0HLA-DQB1
18duodenal ulcer10.0IL8
19bronchiectasis10.0IL8
20hyperglycemia10.0IFNB1
21allergic rhinitis10.0IL8
22rhinitis10.0IL8
23proliferative diabetic retinopathy10.0IL8
24cholera10.0IFNB1
25pulmonary fibrosis10.0IL8
26chronic inflammatory demyelinating polyradiculoneuropathy10.0IFNB1
27leprosy10.0HLA-DRB1
28liver cirrhosis10.0HLA-DRB1
29pemphigus foliaceus10.0HLA-DRB1
30pemphigus vulgaris10.0HLA-DRB1
31kidney cancer10.0TP53
32thyroiditis10.0HLA-DRB1
33sarcoma10.0TP53
34severe combined immunodeficiency10.0IFNB1
35herpes simplex10.0IFNB1
36malaria10.0HLA-DRB1
37peptic ulcer10.0IL8
38colorectal cancer10.0TP53
39lung cancer10.0TP53
40periodontitis10.0IL8
41liposarcoma10.0TP53
42common cold10.0IL8
43encephalomyelitis10.0HLA-DQB1, IFNB1
44kaposi's sarcoma10.0IL6
45celiac disease10.0HLA-DQB1, HLA-DQA1
46retinoblastoma10.0TP53
47galactosemia10.0IL6
48malignant glioma10.0TP53, IFNB1
49hepatitis c10.0HLA-DRB1, IFNB1
50deficiency anemia10.0IL6

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to common wart

Clinical Features for Common Wart

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • raised wart

Drugs & Therapeutics for Common Wart

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Common Wart

Anatomical Context for Common Wart

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Common Wart:

33
Skin

FMA organs/tissues related to Common Wart:

14
Skin

Animal Models for Common Wart or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Common Wart:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.2NFIC, NFIX, HLA-DQB1
2MP:00053909.0NFIX, NFIC, IL6
3MP:00053977.4TP53, IL6, IL8, HLA-DQA1, HLA-DQB1, IFNB1
4MP:00053877.1IFNB1, HLA-DQB1, HLA-DQA1, IL8, IL6, TP53

Publications for Common Wart

Sources:
51PubMed
See all sources

Articles related to Common Wart:

(show all 31)
idTitleAuthorsYear
1
Measles, mumps, and rubella vaccine: a new option to treat common warts? (23786798)
2013
2
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. (22277059)
2013
3
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. (23135096)
2012
4
Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine. (20202055)
2010
5
CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. (18181164)
2008
6
Treatment options for the common wart. (18210913)
2007
7
Role of human papilloma virus (HPV) in common and genital warts and its relation to P53 expression. (17496936)
2006
8
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. (17214114)
2006
9
Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. (15994480)
2005
10
Human leukocyte antigen class II alleles and natural history of HPV 2/27/57-induced common warts. (15257408)
2004
11
Molecular analysis of the effect of topical imiquimod treatment of HPV 2/27/57-induced common warts. (15452412)
2004
12
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). (12361440)
2002
13
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? (12361441)
2002
14
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. (11525958)
2001
15
Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. (11069514)
2000
16
Drug treatment of common STDs: Part II. Vaginal infections, pelvic inflammatory disease and genital warts. (10537386)
1999
17
Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. (8734914)
1996
18
Efficacious treatment of the common wart (verruca vulgaris). (1462533)
1992
19
Systemic treatment of common warts with beta-interferon]. (1917463)
1991
20
Characterization of two HPV-3 related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis. (6302170)
1983
21
An unusual transformation of a common wart in a child. (6269499)
1981
22
Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema. (7248909)
1981
23
Stump the experts. A common wart. (7338585)
1981
24
The common wart: intralesional treatment with bleomycin sulfate. (6159138)
1980
25
Treatment of the common wart by induced allergic inflammation. (7389963)
1980
26
Treatment of the common wart with a virus vaccine. (14477428)
1962
27
Morphological characterization of the virus of the human common wart (verruca vulgaris). (13785470)
1961
28
Aralen and plaquenil in treatment of the common wart. (13726985)
1961
29
Treatment of the common wart by x-ray therapy. (13164671)
1954
30
Common wart conjunctivitis. (13196997)
1954
31
Contact x-ray therapy of the common wart. (14914174)
1952

Genetic Variations for Common Wart

Expression for genes affiliated with Common Wart

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Common Wart

Search GEO for disease gene expression data for Common Wart.

Pathways for genes affiliated with Common Wart

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN, 30KEGG, 56SinoBiological, 53R&D Systems
See all sources

Pathways related to Common Wart according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-DRB1
29.5IL6, IL8
39.5IL6, IL8
49.3TP53, IL6
5
Immune response NFAT in immune response
Hide members
9.3HLA-DQA1, HLA-DRB1, HLA-DQB1
6
Hide members
9.3HLA-DQA1, HLA-DRB1, HLA-DQB1
7
Hide members
9.3HLA-DQA1, HLA-DRB1, HLA-DQB1
89.3HLA-DQB1, HLA-DRB1, HLA-DQA1
99.3HLA-DQA1, HLA-DRB1, HLA-DQB1
109.3HLA-DQA1, HLA-DRB1, HLA-DQB1
11
Hide members
9.3HLA-DQB1, HLA-DRB1, HLA-DQA1
12
Hide members
9.3HLA-DQA1, HLA-DRB1, HLA-DQB1
139.3HLA-DQB1, HLA-DRB1, HLA-DQA1
149.3HLA-DQA1, HLA-DRB1, HLA-DQB1
15
Hide members
9.3HLA-DQA1, HLA-DRB1, HLA-DQB1
169.3HLA-DQB1, HLA-DRB1, HLA-DQA1
17
Immune response ICOS pathway in T-helper cell
Hide members
9.3HLA-DQB1, HLA-DRB1, HLA-DQA1
18
Immune response Antigen presentation by MHC class II
Hide members
9.3HLA-DQA1, HLA-DRB1, HLA-DQB1
199.3HLA-DQB1, HLA-DRB1, HLA-DQA1
20
Hide members
9.3HLA-DQB1, HLA-DRB1, HLA-DQA1
219.2IL8, IFNB1
22
Hide members
9.2TP53, HLA-DQA1, HLA-DQB1
239.1IL6, IFNB1
24
Hide members
9.0TP53, IFNB1
25
Hide members
8.9IL8, IL6, TP53
268.9TP53, IL6, IL8
278.9TP53, IL6, IL8
28
Hide members
8.8IL6, HLA-DQA1, HLA-DRB1, HLA-DQB1
29
Hide members
8.8HLA-DQB1, HLA-DRB1, HLA-DQA1, IL6
308.7IL6, IL8, IFNB1
31
Hide members
8.7IFNB1, IL8, IL6
328.7IFNB1, IL8, IL6
338.7HLA-DQB1, HLA-DRB1, HLA-DQA1, TP53
348.6TP53, IL8, IFNB1
358.6TP53, IL8, IFNB1
368.2TP53, IL6, HLA-DQA1, HLA-DRB1, HLA-DQB1
37
Hide members
8.2TP53, IL6, HLA-DQA1, HLA-DRB1, HLA-DQB1
38
Hide members
8.1IFNB1, IL8, IL6, TP53
39
Hide members
8.1IFNB1, IL8, IL6, TP53
408.0IFNB1, HLA-DQB1, HLA-DRB1, HLA-DQA1, IL6
41
Hide members
8.0IFNB1, HLA-DQB1, HLA-DRB1, HLA-DQA1, IL6
42
Hide members
8.0IL6, HLA-DQA1, HLA-DRB1, HLA-DQB1, IFNB1
43
Hide members
6.9TP53, IL6, IL8, HLA-DQA1, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Common Wart

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Common Wart according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dpa 14510.1HLA-DRB1, HLA-DQA1
2anaphylatoxin4510.1IL8
3emedastine45 1111.0IL6, IL8
4tepoxalin4510.0IL8, IL6
5cycloheximide4510.0IFNB1
6lapatinib45 50 1112.0HLA-DQA1, HLA-DRB1
7sivelestat4510.0IL8, IL6
8rebamipide459.9IL6, IL8
9olopatadine45 1110.9IL8, IL6
10taurine chloramine459.9IL8, IL6
11gabexate mesilate459.9IL6, IL8
12u0126459.9IL8, IL6
13mcp 1459.9IL8, IL6
14gold sodium thiomalate459.9HLA-DRB1, IL8
15hbd2459.9IL8, IL6
16mip 1alpha459.9IL6, IL8
17il-12459.8IL8, IL6
18tpck459.7IL8, IL6
19polymyxin b459.5IL8, IL6
20glatiramer acetate45 1110.5IFNB1, HLA-DRB1
21flagellin45 2910.5IFNB1, IL8
22groalpha459.4IL6, IL8
23acnu459.4TP53, IFNB1
24triptolide459.4IL8, IL6, TP53
25parthenolide45 210.4TP53, IL6, IL8
26hpvs459.4TP53, IFNB1
27pdtc459.3TP53, IL6, IL8
28sp 60012545 6010.3TP53, IL6, IL8
29rantes459.2IL6, IFNB1
30temozolomide45 1110.2TP53, IFNB1
31curcumin459.2TP53, IL6, IL8
32hcec459.2IL6, IL8, IFNB1
33imiquimod45 29 60 1112.2IL6, IL8, IFNB1
34lipoteichoic acid459.2IL6, IL8, IFNB1
35polyinosinic-polycytidylic acid459.2IFNB1, IL8, IL6
36poly(i-c)459.2IL6, IL8, IFNB1
37il 10459.2IFNB1, IL8, IL6
38peptidoglycan45 2910.1IL6, IL8, IFNB1
39ccl345 2910.1IL6, IL8, IFNB1
40neopterin459.1IL6, IL8, IFNB1
41simvastatin45 50 60 29 11 2414.1IL6, IL8, IFNB1
42herbimycin a45 6010.1IFNB1, IL8, IL6
43methotrexate45 50 1110.9IL6, HLA-DRB1, IFNB1
44n acetylcysteine458.6TP53, IL6, IL8
45sb 20358045 609.5IFNB1, IL8, IL6, TP53
46ly294002458.5IFNB1, IL8, IL6, TP53
47actinomycin d458.5IFNB1, IL8, IL6, TP53
48oligonucleotide458.3TP53, HLA-DQA1, HLA-DRB1, HLA-DQB1, IFNB1
49vegf458.2TP53, IL6, IL8, IFNB1

GO Terms for genes affiliated with Common Wart

Sources:
16Gene Ontology
See all sources

Cellular components related to Common Wart according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.5HLA-DQB1, HLA-DRB1, HLA-DQA1
2clathrin-coated endocytic vesicle membraneGO:0306699.5HLA-DQA1, HLA-DQB1, HLA-DRB1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.4HLA-DRB1, HLA-DQA1, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:0125079.4HLA-DQA1, HLA-DRB1, HLA-DQB1
5transport vesicle membraneGO:0306589.3HLA-DQB1, HLA-DRB1, HLA-DQA1
6lysosomal membraneGO:0057659.3HLA-DQB1, HLA-DRB1, HLA-DQA1
7trans-Golgi network membraneGO:0325889.2HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:0306669.0HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Common Wart according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DRB1, HLA-DQB1
2interferon-gamma-mediated signaling pathwayGO:0603339.5HLA-DQB1, HLA-DRB1, HLA-DQA1
3humoral immune response mediated by circulating immunoglobulinGO:0024559.5HLA-DRB1, HLA-DQB1
4T cell costimulationGO:0312959.5HLA-DQA1, HLA-DRB1, HLA-DQB1
5T cell receptor signaling pathwayGO:0508529.4HLA-DQA1, HLA-DRB1, HLA-DQB1
6protein tetramerizationGO:0512629.4TP53, HLA-DRB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.4HLA-DQB1, HLA-DRB1, HLA-DQA1
8immune responseGO:0069559.1HLA-DQB1, HLA-DRB1, HLA-DQA1, IL8
9response to antibioticGO:0466779.0TP53, IL6
10cytokine-mediated signaling pathwayGO:0192218.2IL6, HLA-DQA1, HLA-DRB1, HLA-DQB1, IFNB1
11negative regulation of cell proliferationGO:0082858.1IFNB1, IL8, IL6, TP53
12positive regulation of transcription from RNA polymerase II promoterGO:0459447.9IFNB1, NFIX, NFIC, IL6, TP53

Molecular functions related to Common Wart according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.3HLA-DQA1, HLA-DRB1, HLA-DQB1

Products for genes affiliated with Common Wart

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Common Wart

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet