MCID: CMM008
MIFTS: 35

Communicating Hydrocephalus

Categories: Neuronal diseases, Rare diseases, Fetal diseases

Aliases & Classifications for Communicating Hydrocephalus

MalaCards integrated aliases for Communicating Hydrocephalus:

Name: Communicating Hydrocephalus 12 28 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1573
ICD10 32 G91.0
ICD9CM 34 331.3
MeSH 41 D006849
NCIt 46 C34501
SNOMED-CT 64 271569006 59013007
UMLS 69 C0009451

Summaries for Communicating Hydrocephalus

MalaCards based summary : Communicating Hydrocephalus is related to hydrocephalus and acoustic neuroma. An important gene associated with Communicating Hydrocephalus is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways is Alzheimers Disease Pathway. Affiliated tissues include testes, brain and b cells.

Related Diseases for Communicating Hydrocephalus

Diseases in the Communicating Hydrocephalus family:

Congenital Communicating Hydrocephalus

Diseases related to Communicating Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 31.0 APOE HYDIN MAPT PTGDS SFMBT1 TGFB1
2 acoustic neuroma 29.7 OGG1 TGFB1
3 hydrocephalus, normal-pressure 26.5 ADAMTS2 APOE DNAH14 FRMD4A MAPT MS4A6A
4 congenital communicating hydrocephalus 12.2
5 congenital non-communicating hydrocephalus 12.1
6 hydrocephalus, endocardial fibroelastosis, and cataracts 11.6
7 kozlowski brown hardwick syndrome 11.4
8 chiari malformation type i 10.9
9 coenurosis 10.9
10 cole-carpenter syndrome 10.9
11 chiari malformation 10.9
12 cerebritis 10.1
13 posterior cortical atrophy 10.1 APOE MAPT
14 semantic dementia 10.0 APOE MAPT
15 dementia 10.0
16 meningitis 10.0
17 familial idiopathic basal ganglia calcification 10.0 APOE MAPT
18 binswanger's disease 10.0 APOE MAPT
19 arachnoiditis 10.0
20 alzheimer disease 2 9.9 APOE MAPT
21 cerebral amyloid angiopathy, cst3-related 9.9 APOE MAPT
22 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.9
23 choroiditis 9.9
24 glioblastoma 9.9
25 brain injury 9.8 APOE MAPT
26 systemic lupus erythematosus 9.8
27 lupus erythematosus 9.8
28 intracranial hypertension 9.8
29 ependymoma 9.8
30 glioma 9.8
31 aneurysm 9.8
32 glioma susceptibility 1 9.7
33 cerebellar hypoplasia 9.7
34 intracranial hypertension, idiopathic 9.7
35 ayme-gripp syndrome 9.7
36 hydrops fetalis, nonimmune, and/or atrial septal defect 9.7
37 papilledema 9.7
38 glioblastoma multiforme 9.7
39 arachnoid cysts 9.7
40 hydrops fetalis 9.7
41 transposition of the great arteries 9.7
42 cerebral atrophy 9.7
43 aphasia 9.7 APOE MAPT
44 dementia, lewy body 9.6 ADAMTS2 APOE MAPT
45 disease of mental health 9.6 ADAMTS2 APOE MAPT
46 seizures, benign familial neonatal, 1 9.6
47 cryoglobulinemia, familial mixed 9.6
48 schizophrenia 9.6
49 tetralogy of fallot 9.6
50 craniosynostosis with fibular aplasia 9.6

Comorbidity relations with Communicating Hydrocephalus via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Hypertension, Essential Hypothyroidism
Obstructive Hydrocephalus Parkinson Disease, Late-Onset
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Communicating Hydrocephalus:



Diseases related to Communicating Hydrocephalus

Symptoms & Phenotypes for Communicating Hydrocephalus

Drugs & Therapeutics for Communicating Hydrocephalus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
2 ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus Terminated NCT00946127 Phase 3
3 Third Ventriculostomy Versus Shunt for Children With Hydrocephalus Completed NCT01801267
4 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life Completed NCT01367977
5 Improved Analysis Methods for Infusion Tests Completed NCT01319136
6 Keyhole Surgery for the Positioning of the Distal Catheter in Ventricular Peritoneal Shunt Placement Completed NCT01739179
7 Study of Choroid Plexus Cauderization in Patients With Hydrocephalus Recruiting NCT02900222
8 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138
9 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life Withdrawn NCT01377805

Search NIH Clinical Center for Communicating Hydrocephalus

Genetic Tests for Communicating Hydrocephalus

Genetic tests related to Communicating Hydrocephalus:

# Genetic test Affiliating Genes
1 Communicating Hydrocephalus 28

Anatomical Context for Communicating Hydrocephalus

MalaCards organs/tissues related to Communicating Hydrocephalus:

38
Testes, Brain, B Cells

Publications for Communicating Hydrocephalus

Articles related to Communicating Hydrocephalus:

(show top 50) (show all 301)
# Title Authors Year
1
Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis comparable with mechanisms seen in inflammatory pathways? Part I: historical observations and clinical perspectives on the etiology of increased CSF protein levels, CSF clotting, and communicating hydrocephalus: a comprehensive review. ( 28265819 )
2017
2
Cerebrospinal fluid dynamics study in communicating hydrocephalus. ( 28484522 )
2017
3
"Pure" Suprasellar Schwannoma Presented with Communicating Hydrocephalus: A Case Report. ( 28840085 )
2017
4
Symptomatic communicating hydrocephalus in a contemporary cohort of high grade glioma patients. ( 29160137 )
2017
5
Secondary communicating hydrocephalus management by implantation of external ventricular shunt and minimal gradual increase of cerebrospinal fluid pressure. ( 28484529 )
2017
6
Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans. ( 28575905 )
2017
7
Analysis of risk factors to predict communicating hydrocephalus following gamma knife radiosurgery for intracranial schwannoma. ( 27882725 )
2016
8
Evaluation of the flow of cerebrospinal fluid as well as gender and age characteristics in patients with communicating hydrocephalus, using phase-contrast magnetic resonance imaging. ( 26848963 )
2016
9
New concept of the pathogenesis and therapeutic orientation of acquired communicating hydrocephalus. ( 27115894 )
2016
10
Communicating Hydrocephalus Due to Traumatic Lumbar Spine Injury: Case Report and Literature Review. ( 27323322 )
2016
11
The prevalence of cardiovascular disease in non-communicating hydrocephalus. ( 27455422 )
2016
12
Communicating hydrocephalus associated with small- to medium-sized vestibular schwannomas: clinical significance of the tumor apparent diffusion coefficient map. ( 27423198 )
2016
13
Communicating Hydrocephalus Associated with Intracranial Schwannoma Treated by Gamma Knife Radiosurgery. ( 26585729 )
2016
14
Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. ( 27246837 )
2016
15
Intraventricular administration of urokinase as a novel therapeutic approach for communicating hydrocephalus. ( 27614013 )
2016
16
Imaging of Communicating Hydrocephalus. ( 27063660 )
2016
17
Ventricular Volume Load Reveals the Mechanoelastic Impact of Communicating Hydrocephalus on Dynamic Cerebral Autoregulation. ( 27415784 )
2016
18
Communicating Hydrocephalus Onset Following a Traumatic Tension Pneumocephalus. ( 28913289 )
2016
19
Communicating hydrocephalus, a long-term complication of dural tear during lumbar spine surgery. ( 26521076 )
2015
20
A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus. ( 27708931 )
2015
21
Persistent communicating hydrocephalus in adult tuberous sclerosis patients: a possible therapeutic role for everolimus. ( 25524658 )
2015
22
Surgical management of non-communicating hydrocephalus in patients: meta-analysis and comparison of endoscopic third ventriculostomy and ventriculoperitoneal shunt. ( 25699529 )
2015
23
A hypothesis of traumatic subdural effusion associated with communicating hydrocephalus in infants and its management. ( 25675020 )
2015
24
Association between ventricular volume measures and pulsatile and static intracranial pressure scores in non-communicating hydrocephalus. ( 25680584 )
2015
25
Communicating hydrocephalus in systemic lupus erythematosus. ( 25031142 )
2014
26
Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus. ( 24996196 )
2014
27
Early manifestation of communicating hydrocephalus after fractionated stereotactic radiotherapy for aggressive giant atypical prolactinoma. ( 24778068 )
2014
28
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
29
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. ( 23512254 )
2014
30
Communicating hydrocephalus with reversible cognitive impairment. ( 24589982 )
2014
31
Microgravity environment and compensatory: Decompensatory phases for intracranial hypertension form new perspectives to explain mechanism underlying communicating hydrocephalus and its related disorders. ( 24891884 )
2014
32
Pemetrexed and communicating hydrocephalus. ( 24940146 )
2014
33
Is endoscopic third ventriculostomy superior to shunts in patients with non-communicating hydrocephalus? A systematic review and meta-analysis of the evidence. ( 23456239 )
2013
34
Gravity assisted vs. medium pressure valves for communicating hydrocephalus show similar valve-revision rates. ( 23989996 )
2013
35
Communicating hydrocephalus in metachromatic leukodystrophy. ( 23830584 )
2013
36
Comparative study of lumboperitoneal shunt versus ventriculoperitoneal shunt in post meningitis communicating hydrocephalus in children. ( 24262455 )
2013
37
Decorin prevents the development of juvenile communicating hydrocephalus. ( 23983032 )
2013
38
Communicating hydrocephalus accompanied by arachnoid cyst in aneurismal subarachnoid hemorrhage. ( 24729958 )
2013
39
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus. ( 23560698 )
2013
40
Molecular targets for neonatal communicating hydrocephalus, putting shunts out to pasture? ( 23511831 )
2013
41
Communicating hydrocephalus and vestibular schwannomas: etiology, treatment, and long-term follow-up. ( 24436891 )
2013
42
Thrombin-induced TGF-I^1 pathway: a cause of communicating hydrocephalus post subarachnoid hemorrhage. ( 23338707 )
2013
43
Hearing loss following ventriculoperitoneal shunt in communicating hydrocephalus patients: a pilot study. ( 24318317 )
2013
44
Communicating hydrocephalus caused by an unruptured perimedullary arteriovenous fistula in the lumbar region of an infant. ( 23240850 )
2013
45
Clinical characteristics and neuroimaging findings in 12 cases of recurrent glioblastoma with communicating hydrocephalus. ( 23883558 )
2013
46
Aqueductal flow of cerebrospinal fluid (CSF) and anatomical configuration of the cerebral aqueduct (AC) in patients with communicating hydrocephalus--the trumpet sign. ( 23318053 )
2013
47
Efficacy of endoscopic third ventriculostomy in non-communicating hydrocephalus. ( 24397077 )
2012
48
Historical considerations of the predominance of lumboperitoneal shunt for treatment of adult communicating hydrocephalus in Kumamoto, Japan. ( 22397970 )
2012
49
Neocortical capillary flow pulsatility is not elevated in experimental communicating hydrocephalus. ( 21934694 )
2012
50
Reactive gliosis and neuroinflammation in rats with communicating hydrocephalus. ( 22583796 )
2012

Variations for Communicating Hydrocephalus

Expression for Communicating Hydrocephalus

Search GEO for disease gene expression data for Communicating Hydrocephalus.

Pathways for Communicating Hydrocephalus

Pathways related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 APOE MAPT

GO Terms for Communicating Hydrocephalus

Biological processes related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to radiation GO:0009314 9.16 OGG1 TGFB1
2 negative regulation of blood vessel endothelial cell migration GO:0043537 8.96 APOE TGFB1
3 positive regulation of superoxide anion generation GO:0032930 8.62 MAPT TGFB1

Molecular functions related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Communicating Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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