MCID: CMP008
MIFTS: 44

Compartment Syndrome

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Compartment Syndrome

MalaCards integrated aliases for Compartment Syndrome:

Name: Compartment Syndrome 12 50 14
Compartment Syndromes 52 42 69
Compartmental Syndrome, Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:682
ICD10 33 T79.A0
ICD9CM 35 958.90
MeSH 42 D003161
NCIt 47 C118422
UMLS 69 C0009492

Summaries for Compartment Syndrome

MalaCards based summary : Compartment Syndrome, also known as compartment syndromes, is related to anterior compartment syndrome and visual snow syndrome, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Compartment Syndrome is MB (Myoglobin). The drugs Propofol and Choline have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Compartment syndrome is a condition in which increased pressure within one of the body\'s compartments... more...

Related Diseases for Compartment Syndrome

Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
id Related Disease Score Top Affiliating Genes
1 anterior compartment syndrome 12.2
2 visual snow syndrome 10.7 MB PIK3C2A
3 endometrial type cervical adenomyoma 10.7 MB PIK3C2A
4 inferior myocardial infarction 10.7 MB PIK3C2A
5 hereditary choroidal atrophy 10.7 MB PIK3C2A
6 porphyria 10.7 F2 MB
7 glomerulonephritis 10.7 MB PIK3C2A
8 adrenal carcinoma 10.7 F2 PIK3C2A
9 non-hodgkin lymphoma, during pregnancy 10.7 ALB F2
10 localized chondrosarcoma 10.6 ALB PIK3C2A
11 tracheal calcification 10.6 CHKB TNF
12 inferolateral myocardial infarct 10.6 F2 MB
13 oral cavity carcinoma in situ 10.6 ALB F2
14 brachial plexus neuropathy 10.6 MB PIK3C2A
15 pancreatic cystadenocarcinoma 10.6 ALB F2
16 congenital dyserythropoietic anemia 10.6 ALB TNF
17 epstein-barr virus hepatitis 10.6 PIK3C2A TNF
18 duane retraction syndrome 10.6 ALB F2
19 chronic inflammatory demyelinating polyneuritis 10.6 ALB F2
20 tetanus 10.6 PIK3C2A TNF
21 pyrimidine metabolic disorder 10.6 ALB PIK3C2A
22 cataract 10.6 ALB TNF
23 angelucci's syndrome 10.6 ALB F2
24 plantar fasciitis 10.6 MB PIK3C2A
25 atrophic vulva 10.6 ALB F2
26 burning mouth syndrome 10.6 F2 TNF
27 floppy infant syndrome 10.6 CHKB F8
28 parasitic helminthiasis infectious disease 10.6 MB PIK3C2A
29 vogt-koyanagi-harada disease 10.6 PIK3C2A TNF
30 idiopathic juvenile osteoporosis 10.5 ALB MB
31 polyarteritis nodosa 10.5 ALB TNF
32 childhood brain stem glioma 10.5 ALB F2
33 dermatomycosis 10.5 ALB TNF
34 myopia 10.5 ALB F2
35 myopathy, distal, tateyama type 10.5 CHKB MB PIK3C2A
36 velocardiofacial syndrome 10.5 CHKB MB PIK3C2A
37 chorea gravidarum 10.5 CHKB MB PIK3C2A
38 tonsil cancer 10.5 ALB SLC17A5
39 polysyndactyly trigonocephaly agenesis of corpus callosum 10.5 CHKB MB PIK3C2A
40 bladder diverticulum 10.5 ALB TNF
41 adult intracranial malignant hemangiopericytoma 10.5 CHKB MB PIK3C2A
42 von willibrand disease, type 3 10.4 F2 F8
43 adult respiratory distress syndrome 10.4 CHKB MB PIK3C2A
44 immunodeficiency 34, mycobacteriosis, x-linked 10.4 CHKB MB PIK3C2A
45 female breast cancer 10.4 F2 F8
46 social phobia 10.4 F2 F8
47 adenocarcinoma 10.4 ALB MB PIK3C2A
48 microphthalmia, isolated, with coloboma 7 10.4 MB PIK3C2A
49 autonomic neuropathy 10.4 F2 F8
50 rheumatoid lung disease 10.4 F2 F8

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to Compartment Syndrome

Symptoms & Phenotypes for Compartment Syndrome

UMLS symptoms related to Compartment Syndrome:


muscle cramp, muscle rigidity, muscle spasticity, muscle weakness, myalgia

MGI Mouse Phenotypes related to Compartment Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 HELLS MB PIK3C2A SLC17A5 TNF AAAS
2 growth/size/body region MP:0005378 9.76 AAAS EVC2 F2 HELLS MB PIK3C2A
3 homeostasis/metabolism MP:0005376 9.65 AAAS ALB CHKB F2 F8 HELLS
4 mortality/aging MP:0010768 9.28 ALB EVC2 F2 F8 HELLS MB

Drugs & Therapeutics for Compartment Syndrome

Drugs for Compartment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Choline Approved, Nutraceutical Phase 4 62-49-7 305
3 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
4 Anesthetics Phase 4
5 Central Nervous System Depressants Phase 4
6 Cytidine Diphosphate Choline Phase 4
7 Nootropic Agents Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Hypnotics and Sedatives Phase 4
11 Kava Nutraceutical Phase 4 9000-38-8
12
Dalteparin Approved Phase 3 9005-49-6
13
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
14
Ticagrelor Approved Phase 3 274693-27-5 9871419
15
Tranexamic Acid Approved Phase 3 1197-18-8 5526
16
Clopidogrel Approved, Nutraceutical Phase 3 120202-66-6, 113665-84-2 60606
17 calcium heparin Phase 3
18 Heparin, Low-Molecular-Weight Phase 3
19 Vasoconstrictor Agents Phase 3
20 Neurotransmitter Agents Phase 3,Phase 1
21 Platelet Aggregation Inhibitors Phase 3
22 Purinergic P2 Receptor Antagonists Phase 3
23 Purinergic P2Y Receptor Antagonists Phase 3
24 Antifibrinolytic Agents Phase 3
25 Coagulants Phase 3
26 Hemostatics Phase 3
27
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
28
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
29 Cholinergic Antagonists Phase 1, Phase 2
30 Adjuvants, Immunologic Phase 2
31 Anti-Infective Agents Phase 2
32 Antiviral Agents Phase 2
33 Interferon-beta Phase 2
34 interferons Phase 2
35 Antibodies Phase 1, Phase 2
36 Immunoglobulins Phase 1, Phase 2
37 Antioxidants Phase 2
38 Micronutrients Phase 2
39 Protective Agents Phase 2
40 Trace Elements Phase 2
41 Vitamins Phase 2
42 Cola Nutraceutical Phase 1, Phase 2
43
Menthol Approved Phase 1 2216-51-5 16666
44
Carbon monoxide Approved Phase 1 630-08-0 281
45
Neostigmine Approved, Vet_approved Phase 1 59-99-4 4456
46 Peripheral Nervous System Agents Phase 1
47 Autonomic Agents Phase 1
48 Cholinergic Agents Phase 1
49 Cholinesterase Inhibitors Phase 1
50
Furosemide Approved, Vet_approved 54-31-9 3440

Interventional clinical trials:

(show top 50) (show all 88)

id Name Status NCT ID Phase Drugs
1 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
2 Colloids in Severe Trauma Completed NCT00890383 Phase 4 tetrastarch (Voluven)
3 Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava Before and After Fluid Therapy Completed NCT01553422 Phase 4
4 Efficacy of DBM on Fractures of the Shinbone (Tibia) Completed NCT00299052 Phase 4
5 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
6 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
7 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
8 Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control Recruiting NCT02542241 Phase 4 Sodium Chloride [3%];Sodium Chloride [0.9%]
9 Effect of Sedation on Intra-abdominal Pressure Not yet recruiting NCT02944292 Phase 4 Propofol
10 Muscle Oxygenation and Skin Pigmentation Withdrawn NCT00747162 Phase 4
11 The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function Unknown status NCT01077895 Phase 3
12 Percutaneous Catheter Decompression in the Treatment of Elevated Intra-abdominal Pressure Completed NCT01230255 Phase 3
13 Evaluation of Ticagrelor Anti Platelet and Pleiotropic Effects in Patients Undergoing Percutaneous Coronary Intervention for an Acute Coronary Syndrome Completed NCT01626534 Phase 3 Clopidogrel;trigagrelor
14 Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Recruiting NCT02125890 Phase 3 Tranexamic Acid
15 an Educational Program About Abdominal Compartment Syndrome Enrolling by invitation NCT02639013 Phase 3
16 Study of Primary Fascial Closure Rate in Patients With Open Abdomen Treated With Abthera Versus Barker Technique Not yet recruiting NCT02952976 Phase 3
17 Should Colon or Non-colon Originated Lesions be Distinguished? Recruiting NCT02939508 Phase 1, Phase 2
18 Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of MOF on Patients After Open Surgery for a RAAA Recruiting NCT03119701 Phase 2 Interferon Beta-1A;Placebo
19 Stem Cell Transplantation for Stiff Person Syndrome (SPS) Recruiting NCT02282514 Phase 1, Phase 2
20 Vitamin C for Severe Thermal Injuries Not yet recruiting NCT01587261 Phase 2 Vitamin C;Placebo
21 Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity Unknown status NCT01283451 Phase 1
22 Management of Compartment Syndrome With Ultrafiltration Completed NCT00022815 Phase 1
23 Phase I, Arteriocyte Magellan MAR01 Therapy - Compartment Syndrome and Battlefield Trauma Completed NCT01837264 Phase 1
24 In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome Completed NCT01452425 Phase 1
25 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
26 Oral Rehydration Therapy in Burn Patients Enrolling by invitation NCT02124265 Phase 1 CeraLyte 90
27 Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension Not yet recruiting NCT02543658 Phase 1 Neostigmine;The traditional treatment
28 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome Unknown status NCT01171638
29 Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg Unknown status NCT00681616
30 Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis Unknown status NCT00793715
31 The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension. Unknown status NCT02229695
32 Double Blinded, Randomized Clinical Trial of the Twin Star ECSPRESS Monitoring System for the Reduction of the Incidence of Fasciotomy Unknown status NCT01879696
33 The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients Unknown status NCT01072071 furosemide
34 Safety of Spinal Anesthesia in Patients With Tibial Shaft Fracture Unknown status NCT01795287
35 Pre-drilling or Self Drilling External Fixation Pins Unknown status NCT01046747
36 Supraclavicular Blocks for Post-Operative Pain Control in Supracondylar Fracture Fixation, a Retrospective Analysis of Single Shot Catheter Techniques Unknown status NCT02210429
37 Vacuum Assisted Wound Closure (VAWC) and Mesh Mediated Fascial Traction - Prospective Study of a Novel Technique for Open Abdomen Closure Unknown status NCT00494793
38 Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures. Unknown status NCT00431587
39 The Application of Near Infrared Spectroscopy (NIRS) in the Detection of Lower Limb Compartment Syndrome Completed NCT00921271
40 Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome Completed NCT01077934
41 Predicting Acute Compartment Syndrome (PACS) Completed NCT01561261
42 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers Completed NCT01123798
43 This Study Performed to Develop a New Technique for Measuring the Intra Abdominal Pressure Completed NCT02319213
44 Feasibility Study of The Use of FLEX HD® Surgical Implant or STRATTICE® Reconstructive Tissue Matrix in The Closure of Abdominal Wall Defects With Component Separation in Clean or Contaminated Cases Completed NCT01597128
45 Compartmental Overpressures Associated to Reamed Intramedullary Nails Completed NCT00842101
46 INtestinal Failure, multiPle Organ Failure ANd CItrulline Assessment Completed NCT02520440
47 Prospective Study of Ventral Hernia Repair Completed NCT00894582
48 Randomized Trial of Casting Techniques for Displaced Forearm Fractures Completed NCT00823823
49 PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children Completed NCT01296724
50 Reliability of Sensor Spacing for NIRS in Traumatic Tibia Fractures Completed NCT02301832

Search NIH Clinical Center for Compartment Syndrome

Cochrane evidence based reviews: compartment syndromes

Genetic Tests for Compartment Syndrome

Anatomical Context for Compartment Syndrome

MalaCards organs/tissues related to Compartment Syndrome:

39
Colon, Kidney, Testes, Lung, Skin, Liver, Bone

Publications for Compartment Syndrome

Articles related to Compartment Syndrome:

(show top 50) (show all 753)
id Title Authors Year
1
Endoscopic Fascia Release for Forearm Chronic Exertional Compartment Syndrome: Case Report and Surgical Technique. ( 28832205 )
2017
2
Phonomyography as a non-invasive continuous monitoring technique for muscle ischemia in an experimental model of acute compartment syndrome. ( 28867642 )
2017
3
Muscle Microvascular Blood Flow, Oxygenation, pH, and Perfusion Pressure Decrease in Simulated Acute Compartment Syndrome. ( 28872527 )
2017
4
Regional Anesthesia Did Not Delay Diagnosis of Compartment Syndrome: A Case Report of Anterior Compartment Syndrome in the Thigh Not Masked by an Adductor Canal Catheter. ( 28435149 )
2017
5
TRest as a New Diagnostic Variable for Chronic Exertional Compartment Syndrome of the Forearm: A Prospective Cohort Analysis of 124 Athletes. ( 28817409 )
2017
6
Age and dressing type as independent predictors of post-operative infection in patients with acute compartment syndrome of the lower leg. Methodological issues. ( 28932892 )
2017
7
Abdominal compartment syndrome and the open abdomen: any unresolved issues? ( 27941356 )
2017
8
Biomechanical differences between cases with suspected chronic exertional compartment syndrome and asymptomatic controls during running. ( 28869903 )
2017
9
Impending abdominal compartment syndrome from a giant ovarian cyst torsion. ( 28922702 )
2017
10
A Case of Compartment Syndrome in the Scrotum and Inguinal Area Complicating Idiopathic Nephrotic Syndrome of Childhood. ( 28856105 )
2017
11
Gastric Dilatation and Abdominal Compartment Syndrome in a Child with Prader-Willi Syndrome. ( 28588153 )
2017
12
Necrotizing pancreatitis resulting in abdominal compartment syndrome: a case report from a remote northern hospital and literature review. ( 28925916 )
2017
13
Acute Compartment Syndrome after an Olecranon Fracture in a Patient with Mild Hemophilia B. ( 28819614 )
2017
14
A SERIOUS CASE OF ANTHRAX ASSOCIATED WITH COMPARTMENT SYNDROME. ( 28076996 )
2017
15
Compartment Syndrome, Extremity ( 28846257 )
2017
16
Rare case of severe serotonin syndrome leading to bilateral compartment syndrome. ( 28258180 )
2017
17
Popliteal Artery Entrapment or Chronic Exertional Compartment Syndrome? ( 28890727 )
2017
18
Postrenal acute kidney injury and abdominal compartment syndrome associated with bladder pressure: type III rectus sheath hematoma. ( 28905040 )
2017
19
Canthal cutdown for emergent treatment of orbital compartment syndrome. ( 28812399 )
2017
20
Evaluation, diagnosis, and treatment of chronic exertional compartment syndrome: a review of current literature. ( 28952402 )
2017
21
A Case of Hepatorenal Syndrome and Abdominal Compartment Syndrome with High Renal Congestion. ( 28919595 )
2017
22
Dietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment Syndrome. ( 28839121 )
2017
23
Granulomatosis With Polyangiitis Presenting as Acute Compartment Syndrome. ( 27219317 )
2016
24
A NON-OPERATIVE APPROACH TO THE MANAGEMENT OF CHRONIC EXERTIONAL COMPARTMENT SYNDROME IN A TRIATHLETE: A CASE REPORT. ( 27999729 )
2016
25
Comparison of NIRS, serum biomarkers and muscle damage in a porcine balloon compression model of acute compartment syndrome. ( 27537518 )
2016
26
Abdominal Compartment Syndrome in a Pediatric Patient With Cloacal Exstrophy. ( 26921644 )
2016
27
Orbital Compartment Syndrome Leading to Visual Loss following Orbital Floor Reconstruction. ( 27162573 )
2016
28
Compartment syndrome in infants and toddlers. ( 27538943 )
2016
29
Timing of Presentation of Pediatric Compartment Syndrome and its Microsurgical Implication: A Retrospective Review. ( 27893637 )
2016
30
Reperfusion and Compartment Syndrome After Flexible Ureteroscopy in a Patient with an Iliac Vascular Graft. ( 27872901 )
2016
31
Hereditary angioedema presenting as compartment syndrome in a white girl. ( 27397069 )
2016
32
Chronic compartment syndrome is an under-recognized cause of leg-pain. ( 28850491 )
2016
33
Acute compartment syndrome caused by uncontrolled hypothyroidism. ( 28043728 )
2016
34
Methicillin-resistant Staphylococcus aureus infected gluteal compartment syndrome with rhabdomyolysis in a bodybuilder. ( 27190761 )
2016
35
Contralateral compartment syndrome inoculated by invasive group A streptococcus. ( 27802865 )
2016
36
Bilateral gluteal compartment syndrome after thoracic surgery: an unusual complication. ( 27784148 )
2016
37
Rare times rare: The hyponatremia, rhabdomyolysis, anterior compartment syndrome sequence. ( 27186379 )
2016
38
Abdominal intra-compartment syndrome - a non-hydraulic model of abdominal compartment syndrome due to post-hepatectomy hemorrhage in a man with a localized frozen abdomen due to extensive adhesions: a case report. ( 27633658 )
2016
39
Ultrasound-Guided Fasciotomy for Chronic Exertional Compartment Syndrome: A Cadaveric Investigation. ( 27639651 )
2016
40
Spontaneous Extensor Carpi Ulnaris Compartment Syndrome. ( 27118391 )
2016
41
Prehospital Dextrose Extravasation Causing Forearm Compartment Syndrome: A Case Report. ( 27598324 )
2016
42
Testicular compartment syndrome: an overview of pathophysiology, etiology, evaluation, and management. ( 28078225 )
2016
43
Compartment Syndrome of the Leg Associated with Fracture: An Algorithm to Avoid Releasing the Posterior Compartments. ( 27144819 )
2016
44
Regional anesthesia or patient-controlled analgesia and compartment syndrome in orthopedic surgical procedures: a systematic review. ( 27785097 )
2016
45
Abdominal Compartment Syndrome and Necrotizing Pancreatitis Following Extracorporeal Shock Wave Lithotripsy. ( 27462545 )
2016
46
A Case of Acute Compartment Syndrome of the Thigh Associated with Repetitive Athletic Trauma. ( 28810107 )
2016
47
What's new in emergencies, trauma and shock? Acute renal failure and intra-abdominal hypertension in acute compartment syndrome: Any corollaries with acute renal failure in cardiorenal syndrome? ( 27162434 )
2016
48
Nonoperative Management of Chronic Exertional Compartment Syndrome: A Systematic Review. ( 27172084 )
2016
49
Endovascular Management of a Traumatic Infraorbital Pseudoaneurysm Causing Orbital Compartment Syndrome. ( 27841830 )
2016
50
Intra-Abdominal Hypertension and Abdominal Compartment Syndrome: An Underappreciated Cause of Acute Kidney Injury. ( 27113692 )
2016

Variations for Compartment Syndrome

Expression for Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for Compartment Syndrome

GO Terms for Compartment Syndrome

Biological processes related to Compartment Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 F2 F8
2 blood coagulation, intrinsic pathway GO:0007597 8.62 F2 F8

Sources for Compartment Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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