MCID: CMP008
MIFTS: 45

Compartment Syndrome malady

Summaries for Compartment Syndrome

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Compartment syndrome is a limb- and life-threatening condition which occurs after an injury, when there... more...

MalaCards: Compartment Syndrome, also known as compartment syndromes, is related to acute pancreatitis and malignant hyperthermia. An important gene associated with Compartment Syndrome is CHKB (choline kinase beta), and among its related pathways are Selected targets of HNF1 and Selenium Pathway. The compounds warfarin and alpha tocopherol have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Compartment Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

compartment syndrome 8 43
compartment syndromes 45 61
compartmental syndrome, nos 8


External Ids:

Disease Ontology8 DOID:682
ICD9CM27 958.90
MeSH35 D003161

Related Diseases for Compartment Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Compartment Syndrome family:

anterior compartment syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis30.5SLC17A5, MB
2malignant hyperthermia30.1PIK3C2A, MB
3factor v deficiency30.1F8, F2
4factor vii deficiency30.1F8, F2
5venous thrombosis30.0MB, APOH, F8, LRP1, F2
6factor xii deficiency29.8APOH
7anuria29.8MB
8hellp syndrome29.8SLC17A5, APOH
9hypokalemia29.8PIK3C2A, MB
10thrombocytosis29.8F2
11ovarian hyperstimulation syndrome29.8ALB
12ectopic pregnancy29.8CHKB, PIK3C2A
13protein c deficiency29.8F2, APOH
14toxic shock syndrome29.8TNF
15factor xi deficiency29.8F8, F2
16protein s deficiency29.8F2, F8, APOH
17factor viii deficiency29.8F8, F2
18arthritis29.8ALB, TNF, MB
19vascular disease29.8MB, TNF, APOH, F8, PIK3C2A
20systemic lupus erythematosus29.8F2, F8, APOH, TNF
21anterior compartment syndrome10.8
22n syndrome10.8
23capillary leak syndrome10.4
24abdominal aortic aneurysm10.4
25aortic aneurysm10.4
26systemic capillary leak syndrome10.4
27ruptured abdominal aortic aneurysm10.4
28mass syndrome10.4
29pyomyositis10.3
30cystadenoma10.2
31adult syndrome10.2
32char syndrome10.2
33kid syndrome10.2
34back pain10.2
35toxic megacolon10.1
36sciatic neuropathy10.1
37mucinous ovarian cystadenoma10.1
38dengue hemorrhagic fever10.1
39volkmann contracture10.1
40myositis ossificans10.1
41ehlers–danlos syndrome10.1
42micro syndrome10.1
43young syndrome10.1
44german syndrome10.1
45hemorrhagic fever10.1
46vibrio vulnificus infection10.1
47chronic pain10.1
48foot drop10.1
49cholangiocarcinoma10.0CHKA
50adenocarcinoma10.0CHKA

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to compartment syndrome

Clinical Features for Compartment Syndrome

Drugs & Therapeutics for Compartment Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Compartment Syndrome

Drug clinical trials:

Search ClinicalTrials for Compartment Syndrome

Search NIH Clinical Center for Compartment Syndrome

Search CenterWatch for Compartment Syndrome

Genetic Tests for Compartment Syndrome

Anatomical Context for Compartment Syndrome

Animal Models for Compartment Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Compartment Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.8F8, APOH, TNF, MB, PIK3C2A, CHKA
2MP:00053766.3ALB, HELLS, MB, TNF, APOH, F8

Publications for Compartment Syndrome

Sources:
51PubMed
See all sources

Articles related to Compartment Syndrome:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Respiratory functions of burn patients undergoing decompressive laparotomy due to secondary abdominal compartment syndrome. (23790395)
2014
2
Compartment syndrome associated with expansile antebrachial tumors in two dogs. (24432967)
2014
3
MRI findings in crural compartment syndrome: a case series. (24026220)
2014
4
Superior mesenteric artery syndrome and intra-abdominal compartment syndrome in systemic lupus erythematosus. (24335010)
2014
5
Chronic exertional compartment syndrome of the forearm in elite rowers: a technique for mini-open fasciotomy and a report of six cases. (24426965)
2013
6
Compartment syndrome as a spectrum of purple glove syndrome following intravenous phenytoin administration in a young male: a case report and review of literature. (24005736)
2013
7
Well-Leg Compartment Syndrome after Fracture Fixation in Hemilithotomy Position: Case Report of a Preventable Condition. (24335075)
2013
8
Compartment syndrome of the thigh after blunt trauma: a complication not to be ignored. (22218939)
2013
9
Compartment syndrome following thrombolysis: clinical features and associated conditions. (24272271)
2013
10
Spontaneous bilateral compartment syndrome in a HIV-positive patient. (24347455)
2013
11
Transient altitude-induced compartment syndrome associated with fiberglass casts using waterproof cast padding. (23431541)
2013
12
Foot compartment syndrome: diagnosis and management. (24187035)
2013
13
Compartment syndrome of the vein donor leg following an uneventful coronary artery bypass surgery. (23216357)
2013
14
Compartment pressure measurements have poor specificity for compartment syndrome in the traumatized limb. (23321294)
2013
15
Suspected lumbar compartment syndrome: a rare cause of low back pain after strenuous exercise. (24119883)
2013
16
Dengue hemorrhagic Fever and acute compartment syndrome. (23626965)
2013
17
Enoxaparin-associated atraumatic compartment syndrome of the calf. (21559748)
2012
18
Compartment syndrome of the hand and rhabdomyolysis. (22920944)
2012
19
Compartment syndrome after low-energy tibia fractures sustained during athletic competition. (21804415)
2012
20
Premature loss of bone remodeling compartment canopies is associated with deficient bone formation: a study of healthy individuals and patients with Cushing's syndrome. (22162180)
2012
21
Intra-abdominal hypertension and abdominal compartment syndrome - making progress? (22313059)
2012
22
Compartment syndrome complicating acute osteomyelitis of the radius in a neonate: a case report. (23311204)
2012
23
Case presentation: abdominal compartment syndrome complicating posterior spinal fusion. (22211728)
2012
24
Salvaging kidneys with renal allograft compartment syndrome. (22309228)
2012
25
What's new in acute compartment syndrome? (22913965)
2012
26
Medical cause of compartment syndrome: a fatal case of Clostridium septicum. (22669929)
2012
27
Secondary abdominal compartment syndrome causing failure to wean from cardiopulmonary bypass. (22450114)
2012
28
What is the effect of compartment syndrome and fasciotomies on fracture healing in tibial fractures? (21993369)
2011
29
Abdominal Compartment Syndrome complicating massive hemorrhage from an unusual presentation of ruptured ectopic pregnancy. (21912014)
2011
30
Three-limb compartment syndrome and rhabdomyolysis after robotic cystoprostatectomy. (21296253)
2011
31
Nonoperative management of intra-abdominal hypertension and abdominal compartment syndrome: evolving concepts. (21944450)
2011
32
Posterior arm compartment syndrome after a combined supracondylar humeral and capitellar fractures in an adolescent: a case report. (21415676)
2011
33
Patient populations at risk for intra-abdominal hypertension and abdominal compartment syndrome. (21944446)
2011
34
Painful medial knee compartment syndrome in over-45-year-olds. II--technical note: Biomechanical considerations: theoretic analysis of load distribution in the knee according to plane and to gait phase. (21531650)
2011
35
Impending compartment syndrome of the forearm and hand after a pressurized infusion in a patient under general anesthesia -A case report-. (21359085)
2011
36
Chronic exertional compartment syndrome of the forearm in a major league baseball pitcher. (21836122)
2011
37
Acute compartment syndrome of the foot in a soccer player: a case report. (22131567)
2011
38
Unrecognized acute exertional compartment syndrome of the leg and treatment. (21667742)
2011
39
Acute compartment syndrome in obstetric care. (21401532)
2011
40
Acute compartment syndrome with an atypical presentation: a useful clinical lesson. (21541078)
2011
41
Recurrent compartment syndrome: 2 cases and a review of the literature. (20463987)
2010
42
Indomethacin reduces cell damage: shedding new light on compartment syndrome. (20736787)
2010
43
Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment. (17872577)
2007
44
Systemic capillary leak syndrome associated with compartment syndrome. (17878647)
2007
45
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
46
Compartment syndrome following intravenous regional anesthesia. (11097539)
2000
47
Acute anterior compartment syndrome in the leg following strenuous exercise. (9813711)
1998
48
Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome. (3625226)
1987
49
Acute anterior compartment syndrome in the thigh: a case report and review of the literature. (3506062)
1987
50
Neglected acute post exertional anterior compartment syndrome: a case report. (3842737)
1985

Genetic Variations for Compartment Syndrome

Expression for genes affiliated with Compartment Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for genes affiliated with Compartment Syndrome

Sources:
12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Compartment Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ALB, F8, APOH
29.6ALB, F2, TNF

Compounds for genes affiliated with Compartment Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Compartment Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.2PIK3C2A, APOH
2alpha tocopherol4510.0APOH, CHKA, CHKB
3kaolin4510.0APOH, F2, F8
4Coagulation Factor IX1110.0LRP1, F2, F8
5hepaplastin4510.0ALB, SLC17A5, F2
6hydroxyethyl starch459.9ALB, F2, F8
7dantrolene45 29 1111.9PIK3C2A, MB, CHKB
8alpha-hydroxybutyrate459.8SLC17A5, PIK3C2A, MB, CHKB
9succinylcholine45 29 1111.8MB, PIK3C2A, CHKB, SLC17A5
10bezafibrate45 29 1111.7MB, PIK3C2A, CHKB, SLC17A5
11uric acid45 2410.7CHKA, APOH, CHKB, PIK3C2A
12gamma-hydroxybutyrate459.6CHKB, PIK3C2A, MB
13phosphocreatine45 2410.6CHKA, PIK3C2A, CHKB, MB
14heparin45 29 11 2412.6MB, F8, APOH, PIK3C2A, CHKB
15vitamin b12459.6MB, ALB, APOH, SLC17A5
16melphalan45 1110.5PIK3C2A, CHKB, MB, TNF
17halothane45 29 1111.5MB, SLC17A5, CHKB, PIK3C2A, ALB
18endotoxin459.5TNF, APOH, F8, CHKB, SLC17A5
19cocaine45 1110.4SLC17A5, MB, APOH, PIK3C2A, CHKB
20polyethylene glycol459.4SLC17A5, F2, MB, F8, CHKB, ALB
21ivig459.4PIK3C2A, APOH, TNF, ALB, F8
22malondialdehyde459.4SLC17A5, CHKB, PIK3C2A, APOH, CHKA
23homocysteine45 2410.3APOH, F8, F2, PIK3C2A, ALB
24phosphatidylcholine459.3F2, APOH, F8, CHKA, MB
25pge1459.3APOH, F2, SLC17A5, PIK3C2A
26atorvastatin45 50 29 11 2413.2TNF, PIK3C2A, SLC17A5, CHKB, CHKA
27urea45 11 2411.2ALB, SLC17A5, CHKB, CHKA, PIK3C2A
28epinephrine45 11 2411.2F8, PIK3C2A, MB, CHKB, F2, SLC17A5
29n acetylcysteine459.2CHKB, MB, TNF, CHKA, SLC17A5, F2
30phosphorus459.1ALB, PIK3C2A, SLC17A5, CHKA, CHKB, APOH
31thyroxine45 2410.1MB, ALB, PIK3C2A, CHKA, CHKB, SLC17A5
32ascorbic acid45 2410.0MB, PIK3C2A, CHKB, SLC17A5, CHKA, ALB
33simvastatin45 50 60 29 11 2414.0F2, PIK3C2A, CHKA, TNF, CHKB, SLC17A5
34cyclosporin a45 29 6011.0F2, F8, SLC17A5, PIK3C2A, TNF, CHKB
35iron45 249.9ALB, F8, APOH, PIK3C2A, MB, SLC17A5
36polyacrylamide458.9CHKB, CHKA, SLC17A5, F8, APOH, HELLS
37citrate458.9CHKB, F8, ALB, F2, MB, CHKA
38methotrexate45 50 1110.9APOH, PIK3C2A, CHKB, F2, TNF, ALB
39superoxide45 249.7CHKA, CHKB, SLC17A5, APOH, TNF
40prednisolone45 29 1110.7ALB, APOH, TNF, MB, F8, PIK3C2A
41fatty acid458.7CHKA, PIK3C2A, CHKB, LRP1, ALB, APOH
42fibrinogen458.6PIK3C2A, APOH, F8, TNF, CHKB, ALB
43lysine458.5CHKA, CHKB, LRP1, APOH, HELLS, F8
44aspartate458.5F8, CHKB, F2, LRP1, SLC17A5, ALB
45cholesterol45 29 11 2411.5ALB, CHKB, PIK3C2A, CHKA, SLC17A5, F8
46vegf458.4TNF, LRP1, CHKB, PIK3C2A, APOH, MB
47creatinine458.4SLC17A5, F2, CHKB, CHKA, ALB, PIK3C2A
48glucose458.4ALB, LRP1, APOH, SLC17A5, CHKA, CHKB
49lactate458.1ALB, SLC17A5, F2, CHKB, MB, CHKA
50alanine458.0ALB, MB, HELLS, PIK3C2A, SLC17A5, F2

GO Terms for genes affiliated with Compartment Syndrome

Sources:
16Gene Ontology
See all sources

Biological processes related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CDP-choline pathwayGO:0066579.9CHKB, CHKA
2phosphatidylethanolamine biosynthetic processGO:0066469.9CHKB, CHKA
3negative regulation of fibrinolysisGO:0519189.8APOH, F2
4blood coagulation, intrinsic pathwayGO:0075979.8F2, F8, APOH
5positive regulation of blood coagulationGO:0301949.6F2, APOH

Molecular functions related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ethanolamine kinase activityGO:0043059.9CHKB, CHKA
2choline kinase activityGO:0041039.6CHKB, CHKA

Products for genes affiliated with Compartment Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Compartment Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet