MCID: CMP008
MIFTS: 48

Compartment Syndrome

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Compartment Syndrome

MalaCards integrated aliases for Compartment Syndrome:

Name: Compartment Syndrome 12 72 49 14
Compartment Syndromes 51 41 69
Compartmental Syndrome, Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:682
ICD10 32 T79.A0
ICD9CM 34 958.90
MeSH 41 D003161
NCIt 46 C118422
UMLS 69 C0009492

Summaries for Compartment Syndrome

MalaCards based summary : Compartment Syndrome, also known as compartment syndromes, is related to anterior compartment syndrome and metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, and has symptoms including myalgia, muscle weakness and muscle spasticity. An important gene associated with Compartment Syndrome is MB (Myoglobin), and among its related pathways/superpathways is Selenium Micronutrient Network. The drugs Propofol and Kava have been mentioned in the context of this disorder. Affiliated tissues include kidney, colon and testes, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Compartment syndrome is a condition in which increased pressure within one of the body\'s compartments... more...

Related Diseases for Compartment Syndrome

Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 anterior compartment syndrome 34.2 F2 PIK3C2A
2 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 30.7 CHKB MB PIK3C2A
3 burns 30.1 ALB TNF
4 myositis 30.1 CHKB MB PIK3C2A
5 disseminated intravascular coagulation 29.9 F2 MB PIK3C2A
6 hemophilia 29.9 F2 F8
7 malignant hyperthermia 29.9 CHKB MB PIK3C2A
8 plexopathy 29.8 MB PIK3C2A
9 peritonitis 29.8 ALB F2 TNF
10 hepatorenal syndrome 29.7 ALB F2
11 dengue hemorrhagic fever 29.6 ALB F2 TNF
12 anuria 29.6 ALB MB PIK3C2A
13 factor viii deficiency 29.6 F2 F8
14 infective endocarditis 29.5 F2 TNF
15 factor vii deficiency 29.5 F2 F8
16 hepatitis 29.4 F2 SLC17A5 TNF
17 hemophilia b 29.3 F2 F8
18 hemorrhagic fever 29.2 ALB F2 SLC17A5 TNF
19 endocarditis 29.1 ALB F2 PIK3C2A TNF
20 liver disease 28.9 ALB F2 SLC17A5 TNF
21 virus associated hemophagocytic syndrome 10.5 MB PIK3C2A
22 interstitial myocarditis 10.5 MB PIK3C2A
23 posterior myocardial infarction 10.5 MB PIK3C2A
24 myositis fibrosa 10.4 MB PIK3C2A
25 mesenteric vascular occlusion 10.4 F2 MB
26 antipyrine metabolism 10.4 ALB F2
27 non-a-e hepatitis 10.4 ALB F2
28 anteroseptal myocardial infarction 10.4 ALB PIK3C2A
29 adult dermatomyositis 10.4 CHKB TNF
30 subendocardial myocardial infarction 10.4 F2 MB
31 abdominal tuberculosis 10.4 ALB F2
32 hepatic tuberculosis 10.4 ALB F2
33 hepatic coma 10.4 ALB F2
34 intermediate coronary syndrome 10.4 MB PIK3C2A
35 splenic disease 10.4 ALB F2
36 erysipelas 10.4 PIK3C2A TNF
37 esophageal varix 10.4 ALB F2
38 ascending cholangitis 10.4 ALB F2
39 acute kidney tubular necrosis 10.4 ALB MB
40 marburg hemorrhagic fever 10.4 F2 TNF
41 fainting 10.4 CHKB F8
42 crimean-congo hemorrhagic fever 10.4 PIK3C2A TNF
43 tuberculous peritonitis 10.3 ALB TNF
44 hypersplenism 10.3 ALB F2
45 creatine phosphokinase, elevated serum 10.3 CHKB MB PIK3C2A
46 pneumocystosis 10.3 ALB TNF
47 neuroleptic malignant syndrome 10.3 CHKB MB PIK3C2A
48 polymyositis 10.3 CHKB MB PIK3C2A
49 fascioliasis 10.3 ALB SLC17A5
50 hepatic vascular disease 10.3 ALB F2

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to Compartment Syndrome

Symptoms & Phenotypes for Compartment Syndrome

UMLS symptoms related to Compartment Syndrome:


myalgia, muscle weakness, muscle spasticity, muscle rigidity, muscle cramp

MGI Mouse Phenotypes related to Compartment Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 TNF AAAS ALB EVC2 HELLS MB
2 growth/size/body region MP:0005378 9.76 AAAS EVC2 F2 HELLS MB PIK3C2A
3 homeostasis/metabolism MP:0005376 9.65 AAAS ALB CHKB F2 F8 HELLS
4 mortality/aging MP:0010768 9.28 ALB EVC2 F2 F8 HELLS MB

Drugs & Therapeutics for Compartment Syndrome

Drugs for Compartment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
3
Choline Approved, Nutraceutical Phase 4 62-49-7 305
4 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
5 Anesthetics Phase 4
6 Cytidine Diphosphate Choline Phase 4
7 Nootropic Agents Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Central Nervous System Depressants Phase 4
11 Hypnotics and Sedatives Phase 4
12
Dalteparin Approved Phase 3 9005-49-6
13
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
14
Tranexamic Acid Approved Phase 3 1197-18-8 5526
15
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
16 calcium heparin Phase 3
17 Heparin, Low-Molecular-Weight Phase 3
18 Vasoconstrictor Agents Phase 3
19 Cholinergic Agents Phase 2, Phase 3,Phase 1
20 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
21 Antifibrinolytic Agents Phase 3
22 Coagulants Phase 3
23 Hemostatics Phase 3
24 Botulinum Toxins Phase 2, Phase 3
25
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
26
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 54670067 5785
27 Antioxidants Phase 2
28 Micronutrients Phase 2
29 Protective Agents Phase 2
30 Trace Elements Phase 2
31 Vitamins Phase 2
32 Cholinergic Antagonists Phase 1, Phase 2
33 Adjuvants, Immunologic Phase 2
34 Anti-Infective Agents Phase 2
35 Antiviral Agents Phase 2
36 Interferon-beta Phase 2
37 interferons Phase 2
38 Cola Nutraceutical Phase 1, Phase 2
39
Menthol Approved Phase 1 2216-51-5 16666
40
Neostigmine Approved, Vet_approved Phase 1 59-99-4 4456
41
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
42 Autonomic Agents Phase 1
43 Cholinesterase Inhibitors Phase 1
44 Peripheral Nervous System Agents Phase 1
45
Furosemide Approved, Vet_approved 54-31-9 3440
46
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
47
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
48
Rocuronium Approved 119302-91-9, 143558-00-3 441290
49
Sevoflurane Approved, Vet_approved 28523-86-6 5206
50
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213

Interventional clinical trials:

(show top 50) (show all 83)

# Name Status NCT ID Phase Drugs
1 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
2 Colloids in Severe Trauma Completed NCT00890383 Phase 4 tetrastarch (Voluven)
3 Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava Before and After Fluid Therapy Completed NCT01553422 Phase 4
4 Efficacy of DBM on Fractures of the Shinbone (Tibia) Completed NCT00299052 Phase 4
5 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
6 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
7 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
8 Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control Recruiting NCT02542241 Phase 4 Sodium Chloride [3%];Sodium Chloride [0.9%]
9 Effect of Sedation on Intra-abdominal Pressure Recruiting NCT02944292 Phase 4 Propofol
10 Muscle Oxygenation and Skin Pigmentation Withdrawn NCT00747162 Phase 4
11 an Educational Program About Abdominal Compartment Syndrome Unknown status NCT02639013 Phase 3
12 The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function Unknown status NCT01077895 Phase 3
13 Percutaneous Catheter Decompression in the Treatment of Elevated Intra-abdominal Pressure Completed NCT01230255 Phase 3
14 Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Recruiting NCT02125890 Phase 3 Tranexamic Acid
15 Botulinum for Chronic Exertional Compartment Syndrome Not yet recruiting NCT03339921 Phase 2, Phase 3 Botulinum toxin injections for chronic compartment syndrome
16 Study of Primary Fascial Closure Rate in Patients With Open Abdomen Treated With Abthera Versus Barker Technique Not yet recruiting NCT02952976 Phase 3
17 Vitamin C for Severe Thermal Injuries Unknown status NCT01587261 Phase 2 Vitamin C;Placebo
18 Should Colon or Non-colon Originated Lesions be Distinguished? Recruiting NCT02939508 Phase 1, Phase 2
19 Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of MOF on Patients After Open Surgery for a RAAA Recruiting NCT03119701 Phase 2 Interferon Beta-1A;Placebo
20 Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity Unknown status NCT01283451 Phase 1
21 Oral Rehydration Therapy in Burn Patients Unknown status NCT02124265 Phase 1 CeraLyte 90
22 Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension Unknown status NCT02543658 Phase 1 Neostigmine;The traditional treatment
23 Phase I, Arteriocyte Magellan MAR01 Therapy - Compartment Syndrome and Battlefield Trauma Completed NCT01837264 Phase 1
24 Management of Compartment Syndrome With Ultrafiltration Completed NCT00022815 Phase 1
25 In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome Completed NCT01452425 Phase 1
26 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
27 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome Unknown status NCT01171638
28 Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg Unknown status NCT00681616
29 Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis Unknown status NCT00793715
30 The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension. Unknown status NCT02229695
31 Intra-abdominal Hypertension in Critically Ill Patients Unknown status NCT02514135
32 Double Blinded, Randomized Clinical Trial of the Twin Star ECSPRESS Monitoring System for the Reduction of the Incidence of Fasciotomy Unknown status NCT01879696
33 The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients Unknown status NCT01072071 furosemide
34 Use of Hypertonic Saline After Damage Control Laparotomy to Improve Early Primary Fascial Closure Unknown status NCT02297659
35 Pre-drilling or Self Drilling External Fixation Pins Unknown status NCT01046747
36 Supraclavicular Blocks for Post-Operative Pain Control in Supracondylar Fracture Fixation, a Retrospective Analysis of Single Shot Catheter Techniques Unknown status NCT02210429
37 The Application of Near Infrared Spectroscopy (NIRS) in the Detection of Lower Limb Compartment Syndrome Completed NCT00921271
38 Predicting Acute Compartment Syndrome (PACS) Completed NCT01561261
39 Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome Completed NCT01077934
40 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers Completed NCT01123798
41 This Study Performed to Develop a New Technique for Measuring the Intra Abdominal Pressure Completed NCT02319213
42 Feasibility Study of The Use of FLEX HD® Surgical Implant or STRATTICE® Reconstructive Tissue Matrix in The Closure of Abdominal Wall Defects With Component Separation in Clean or Contaminated Cases Completed NCT01597128
43 Compartmental Overpressures Associated to Reamed Intramedullary Nails Completed NCT00842101
44 INtestinal Failure, multiPle Organ Failure ANd CItrulline Assessment Completed NCT02520440
45 Prospective Study of Ventral Hernia Repair Completed NCT00894582
46 Randomized Trial of Casting Techniques for Displaced Forearm Fractures Completed NCT00823823
47 Reliability of Sensor Spacing for NIRS in Traumatic Tibia Fractures Completed NCT02301832
48 Arm Pump in Motorcross Training Completed NCT02096796
49 PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children Completed NCT01296724
50 Web-based Education Module for Pain Management Completed NCT02435498

Search NIH Clinical Center for Compartment Syndrome

Cochrane evidence based reviews: compartment syndromes

Genetic Tests for Compartment Syndrome

Anatomical Context for Compartment Syndrome

MalaCards organs/tissues related to Compartment Syndrome:

38
Kidney, Colon, Testes, Skin, Liver, Bone, Skeletal Muscle

Publications for Compartment Syndrome

Articles related to Compartment Syndrome:

(show top 50) (show all 777)
# Title Authors Year
1
Out-of-Hospital Lateral Canthotomy and Cantholysis: A Case Series and Screening Tool for Identification of Orbital Compartment Syndrome. ( 29332783 )
2018
2
Acute Compartment Syndrome as a Complication of the Use of Intraoperative Neuromonitoring Needle Electrodes. ( 29408593 )
2018
3
Phlegmasia Cerulea Dolens with Compartment Syndrome. ( 29443665 )
2018
4
Acute Exertional Compartment Syndrome with Rhabdomyolysis: Case Report and Review of Literature. ( 29415981 )
2018
5
Transient Orbital Compartment Syndrome Caused by Spontaneous Lamina Papyracea Dehiscence. ( 29393309 )
2018
6
Delayed Presentation of Compartment Syndrome of the Thigh in a Previously Undiagnosed Factor VII-Deficient High School Football Athlete: A Case Report. ( 29369058 )
2018
7
Systemic Administration of Carbon Monoxide-Releasing Molecule-3 Protects the Skeletal Muscle in Porcine Model of Compartment Syndrome. ( 29384781 )
2018
8
Bladder Distension as a Cause of Abdominal Compartment Syndrome. ( 29394977 )
2018
9
Isolated lateral leg compartment syndrome following an ankle sprain. ( 29305371 )
2018
10
Nursing Assessment of Intra-abdominal Hypertension and Abdominal Compartment Syndrome in the Neonate. ( 29373344 )
2018
11
Diagnosis and Treatment of Chronic Exertional Compartment Syndrome of the Forearm in Motocross Riders. ( 29315124 )
2018
12
Renal Decapsulation Prevents Intrinsic Renal Compartment Syndrome in Ischemia-Reperfusion-Induced Acute Kidney Injury: A Physiologic Approach. ( 29341964 )
2018
13
Bilateral orbital compartment syndrome in a patient with disseminated intravascular coagulation. ( 29308942 )
2018
14
Acute Compartment Syndrome: An Expert Survey of Orthopedic Trauma Association (OTA) Members. ( 29432322 )
2018
15
Acute lumbar paraspinal compartment syndrome: a systematic review. ( 29316189 )
2018
16
After a punch: recurrence of compartment syndrome following minor trauma. ( 29435220 )
2018
17
Acute Compartment Syndrome after an Olecranon Fracture in a Patient with Mild Hemophilia B. ( 28819614 )
2017
18
A SERIOUS CASE OF ANTHRAX ASSOCIATED WITH COMPARTMENT SYNDROME. ( 28076996 )
2017
19
Compartment Syndrome, Extremity ( 28846257 )
2017
20
Age and dressing type as independent predictors of post-operative infection in patients with acute compartment syndrome of the lower leg. Methodological issues. ( 28932892 )
2017
21
Management of ovarian hyperstimulation syndrome with abdominal compartment syndrome, based on intravesical pressure measurement. ( 29259454 )
2017
22
TRest as a New Diagnostic Variable for Chronic Exertional Compartment Syndrome of the Forearm: A Prospective Cohort Analysis of 124 Athletes. ( 28817409 )
2017
23
Impending abdominal compartment syndrome from a giant ovarian cyst torsion. ( 28922702 )
2017
24
A Case of Hepatorenal Syndrome and Abdominal Compartment Syndrome with High Renal Congestion. ( 28919595 )
2017
25
Abdominal compartment syndrome and the open abdomen: any unresolved issues? ( 27941356 )
2017
26
Phonomyography as a non-invasive continuous monitoring technique for muscle ischemia in an experimental model of acute compartment syndrome. ( 28867642 )
2017
27
Dietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment Syndrome. ( 28839121 )
2017
28
Canthal cutdown for emergent treatment of orbital compartment syndrome. ( 28812399 )
2017
29
Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report. ( 29179775 )
2017
30
Lower extremity compartment syndrome after elective percutaneous fenestrated endovascular repair of an abdominal aortic aneurysm. ( 29349373 )
2017
31
Evaluation, diagnosis, and treatment of chronic exertional compartment syndrome: a review of current literature. ( 28952402 )
2017
32
Muscle Microvascular Blood Flow, Oxygenation, pH, and Perfusion Pressure Decrease in Simulated Acute Compartment Syndrome. ( 28872527 )
2017
33
A Case of Compartment Syndrome in the Scrotum and Inguinal Area Complicating Idiopathic Nephrotic Syndrome of Childhood. ( 28856105 )
2017
34
Open 4-Compartment Fasciotomy for Chronic Exertional Compartment Syndrome of the Leg. ( 29349018 )
2017
35
Regional Anesthesia Did Not Delay Diagnosis of Compartment Syndrome: A Case Report of Anterior Compartment Syndrome in the Thigh Not Masked by an Adductor Canal Catheter. ( 28435149 )
2017
36
Acute compartment syndrome of the thigh following hip replacement by anterior approach in a patient using oral anticoagulants. ( 29312856 )
2017
37
Endoscopic Fascia Release for Forearm Chronic Exertional Compartment Syndrome: Case Report and Surgical Technique. ( 28832205 )
2017
38
Influenza A (H3N2)-induced rhabdomyolysis complicating anterior compartment syndrome: Serial changes in muscle MRI T2 fat suppression imaging. ( 29260019 )
2017
39
Postrenal acute kidney injury and abdominal compartment syndrome associated with bladder pressure: type III rectus sheath hematoma. ( 28905040 )
2017
40
Necrotizing pancreatitis resulting in abdominal compartment syndrome: a case report from a remote northern hospital and literature review. ( 28925916 )
2017
41
Popliteal Artery Entrapment or Chronic Exertional Compartment Syndrome? ( 28890727 )
2017
42
Gastric Dilatation and Abdominal Compartment Syndrome in a Child with Prader-Willi Syndrome. ( 28588153 )
2017
43
Rare case of severe serotonin syndrome leading to bilateral compartment syndrome. ( 28258180 )
2017
44
Biomechanical differences between cases with suspected chronic exertional compartment syndrome and asymptomatic controls during running. ( 28869903 )
2017
45
Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome. ( 29341948 )
2017
46
Abdominal Compartment Syndrome After Surgery for Abdominal Aortic Aneurysm: A Nationwide Population Based Study. ( 27107488 )
2016
47
Orbital Compartment Syndrome Leading to Visual Loss following Orbital Floor Reconstruction. ( 27162573 )
2016
48
Intra-Abdominal Hypertension and Abdominal Compartment Syndrome after Abdominal Wall Reconstruction: Quaternary Syndromes? ( 27465223 )
2016
49
A NON-OPERATIVE APPROACH TO THE MANAGEMENT OF CHRONIC EXERTIONAL COMPARTMENT SYNDROME IN A TRIATHLETE: A CASE REPORT. ( 27999729 )
2016
50
Ultrasound-Guided Fasciotomy for Anterior Chronic Exertional Compartment Syndrome of the Leg. ( 28027611 )
2016

Variations for Compartment Syndrome

Expression for Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for Compartment Syndrome

Pathways related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 ALB F2 TNF

GO Terms for Compartment Syndrome

Biological processes related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 F2 F8
2 blood coagulation, intrinsic pathway GO:0007597 8.62 F2 F8

Sources for Compartment Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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