Compartment Syndrome malady

Wikipedia: Compartment syndrome is a limb threatening and life threatening condition which occurs after an injury,...⁴⁴ more...

MalaCards: Compartment Syndrome, also known as compartment syndromes, is related to neuropathy and short-chain acyl-coa dehydrogenase deficiency. An important gene associated with Compartment Syndrome is CHKA (choline kinase alpha), and among its related pathways is Selected targets of HNF1. The compounds phosphorus and phosphocreatine have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Descriptions:

compartment syndrome 6 30 8 compartment syndromes 32 43

compartment syndrome (disorder) 6 compartmental syndrome, nos 6

Diseases related to compartment syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 323)

id	Related Disease	Score	Top Affiliating Genes
1	neuropathy	23.8	PIK3C2A, CHKA, CHKB, APOH, MB, F8
2	short-chain acyl-coa dehydrogenase deficiency	13.4	PIK3C2A, CHKA
3	carotid artery occlusion	13.4	APOH, F8
4	intracranial thrombosis	13.4	APOH, F8
5	catastrophic antiphospholipid syndrome	13.3	APOH, F8
6	lymphangiosarcoma	13.2	F8, TNF
7	intermediate coronary syndrome	13.2	PIK3C2A, MB
8	creatine phosphokinase, elevated serum	13.2	PIK3C2A, CHKB, MB
9	gas gangrene	13.2	PIK3C2A, CHKB, MB
10	anuria	13.2	MB, ALB
11	ullrich congenital muscular dystrophy	13.1	PIK3C2A, CHKA, CHKB
12	malignant hyperthermia	13.1	PIK3C2A, CHKB, MB
13	duchenne muscular dystrophy	13.1	PIK3C2A, CHKB, MB
14	chondrodysplasia punctata 1, x-linked	13.1	F8, F2
15	acquired von willebrand syndrome	13.1	F8, F2
16	thrombosis	13.1	F8, F2
17	factor v deficiency	13.1	F8, F2
18	antiphospholipid syndrome	13.1	APOH, F2
19	hemarthrosis	13.1	F8, F2
20	prothrombin deficiency	13.1	APOH, F2
21	ectopic pregnancy	13.1	PIK3C2A, CHKB
22	syncope	13.1	PIK3C2A, CHKB, MB
23	spinal cord infarction	13.1	APOH, F2
24	retinal vasculitis	13.1	APOH, TNF
25	peripheral vertigo	13.1	APOH, F2
26	cerebral aneurysms	13.0	CHKB, MB, TNF
27	evans' syndrome	13.0	APOH, F2
28	factor viii deficiency	13.0	F8, F2
29	factor xi deficiency	13.0	F8, F2
30	neuroleptic malignant syndrome	13.0	PIK3C2A, CHKA, CHKB, MB
31	rhabdomyolysis, cerivastatin-induced	13.0	PIK3C2A, CHKA, CHKB, MB
32	antithrombin iii deficiency	13.0	APOH, F2
33	papilledema	13.0	APOH, F2
34	nephropathia epidemica	13.0	PIK3C2A, TNF
35	calciphylaxis	13.0	PIK3C2A, ALB
36	achenbach syndrome	13.0	CHKB, F8, F2
37	purpura fulminans	13.0	APOH, F2
38	polymyalgia rheumatica	12.9	APOH, F8, TNF
39	bronchiolitis obliterans organizing pneumonia	12.9	PIK3C2A, CHKA, ALB
40	adult dermatomyositis	12.9	PIK3C2A, CHKB, TNF
41	hemorrhagic disease	12.9	F8, F2
42	acute kidney tubular necrosis	12.9	PIK3C2A, MB, ALB
43	pericardial effusion	12.9	PIK3C2A, CHKB, ALB
44	cocaine abuse	12.9	PIK3C2A, CHKB, APOH, MB
45	sneddon syndrome	12.9	APOH, F8, F2
46	diabetic ketoacidosis	12.9	PIK3C2A, CHKB, ALB
47	factor xii deficiency	12.9	APOH, F8, F2
48	central retinal vein occlusion	12.9	APOH, F8, F2
49	erysipelas	12.9	PIK3C2A, TNF
50	thrombophlebitis	12.9	APOH, F8, F2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to compartment syndrome:

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MGI Mouse Phenotypes related to compartment syndrome:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	6.2	HELLS, TNF, ALB, F2, F8, MB
2	homeostasis/metabolism phenotype	MP:0005376	5.6	PIK3C2A, SLC17A5, HELLS, TNF, ALB, F2

Articles related to compartment syndrome:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Compartment syndrome after Bothrops jararaca snakebit e: monitoring, treatment, and outcome. (20095815)	Bucaretchi F.... Fernandes L.C.	2010	CHKB
2	Abdominal compartment syndrome associated with capill ary leak syndrome after liver transplantation. (19917414)	Zhang W.... Sun B.	2009	ALB
3	Abdominal compartment syndrome: a situation thet need s to be better known. (18709776)	Cardia G.... Brienza N.	2008	PIK3C2A
4	Compartment syndrome in patients with Buerger disease and anticardiolipin antibodies. (18580711)	Pereira de Godoy J.M.... Torres C.A.	2008	APOH
5	Morphology, TNFalpha expression and apoptosis in the hearts of patients who died of abdominal compartment syndrome: an immunohistochemical study. (16859780)	Fineschi V.... Turillazzi E.	2007	TNF
6	A new model for the study of the abdominal compartment syndrome in rats. (17254610)	Meier C.... Menger M.D.	2007	CHKB, SLC17A5
7	Do creatine kinase (CK) levels influence the diagnosis or outcome in patients with compartment syndrome? (16374979)	Ihedioha U.... Campbell A.C.	2005	CHKB
8	Neuropathy of common sciatic nerve secondary to compartment syndrome as a complication after bariatric surgery (15726478)	RodrA-guez Uranga J.J.... PAcrez DA-az J.M.	2005	CHKA
9	Abdominal compartment syndrome in the open abdomen. (12413323)	Gracias V.H.... Schwab C.W.	2002	F2
10	Compartment syndrome in both lower legs after prolonged surgery in the lithotomy position (9627455)	Ho G.H.... Ottow R.T.	1998	MB
11	Postoperative bilateral compartment syndrome resulting from prolonged urological surgery in lithotomy position. Serum creatine kinase activity (CK) as a warning signal in sedated, artificially respirated patients (7695079)	Lampert R.... Lang K.	1995	CHKB, MB

Genes related to compartment syndrome according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	CHKA	choline kinase alpha	11.0	Publications
2	CHKB	choline kinase beta	11.0	Publications
3	MB	myoglobin	11.0	Publications
4	F8	coagulation factor VIII, procoagulant component	11.0
5	SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	11.0
6	ZNF143	zinc finger protein 143	11.0
7	AACS	acetoacetyl-CoA synthetase	11.0
8	HELLS	helicase, lymphoid-specific	11.0
9	PPP6R2	protein phosphatase 6, regulatory subunit 2	11.0	Disorders
10	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
11	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
12	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	11.0
13	ALB	albumin	11.0	Publications
14	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
15	F2	coagulation factor II (thrombin)	11.0	Publications
16	TNF	tumor necrosis factor	11.0	Publications

Pathways related to compartment syndrome according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	9.3	APOH, F8, ALB

Compounds related to compartment syndrome according to GeneDecks:

(show top 50)    (show all 133)

id	Compound	Score	Top Affiliating Genes
1	phosphorus32	10.7	CHKA
2	phosphocreatine32 18	11.3	CHKA, PIK3C2A
3	ivig32	10.3	F8, PIK3C2A
4	polyethylene glycol32	10.2	CHKB, MB, F8
5	dantrolene32 9 9	11.9	MB, PIK3C2A, CHKB
6	gamma-hydroxybutyrate32	9.8	PIK3C2A, CHKB, MB
7	creatinine32	9.8	MB, F8, APOH, CHKA
8	ascorbic acid32 18	10.8	CHKA, CHKB, SLC17A5
9	hydroxyethyl starch32	9.7	F8, F2
10	alpha tocopherol32	9.6	ALB, MB, CHKB, CHKA
11	citrate32	9.6	F8, PIK3C2A, CHKA, CHKB, MB
12	glutamate32	9.5	APOH, HELLS, CHKA
13	ptca32	9.5	PIK3C2A, CHKB, APOH
14	alpha-hydroxybutyrate32	9.5	MB, SLC17A5, CHKB, PIK3C2A
15	succinylcholine32 9 9	11.4	PIK3C2A, CHKB, MB, SLC17A5
16	melphalan32 9 9	11.4	MB, TNF, CHKB, PIK3C2A
17	bezafibrate32 9 9	11.3	PIK3C2A, CHKB, SLC17A5, MB
18	kaolin32	9.3	F8, F2, APOH
19	pge132	9.1	APOH, PIK3C2A, SLC17A5
20	carnitine32	9.1	MB, SLC17A5, CHKA, CHKB
21	malondialdehyde32	9.0	APOH, SLC17A5, CHKB, CHKA, PIK3C2A
22	fatty acid32	9.0	SLC17A5, APOH, CHKA, PIK3C2A
23	vitamin b1232	8.9	ALB, MB, APOH, SLC17A5
24	cocaine32 9 9	10.9	PIK3C2A, CHKB, APOH, MB, SLC17A5
25	halothane32 9 9	10.9	ALB, SLC17A5, PIK3C2A, CHKB, MB
26	atorvastatin32 34 9 18 9	12.9	PIK3C2A, CHKA, CHKB, TNF, SLC17A5
27	hepaplastin32	8.9	F2, ALB, SLC17A5
28	urea32 9 18 9	11.9	ALB, CHKB, CHKA, PIK3C2A, SLC17A5
29	polyacrylamide32	8.8	CHKB, F8, HELLS, APOH, CHKA, SLC17A5
30	fibrinogen32	8.8	ALB, PIK3C2A, CHKB, SLC17A5, APOH
31	phosphatidylcholine32	8.8	MB, APOH, F2, CHKA, F8
32	endotoxin32	8.7	SLC17A5, TNF, F8, APOH, CHKB
33	heparin32 9 18 9	11.7	F8, ALB, F2, CHKB, PIK3C2A
34	thyroxine32 18	9.7	ALB, PIK3C2A, SLC17A5, MB, CHKB, CHKA
35	uric acid32 18	9.5	CHKA, SLC17A5, PIK3C2A, CHKB, ALB, APOH
36	warfarin32 34 9 18 9	12.5	F8, APOH, ALB, F2, PIK3C2A
37	homocysteine32 18	9.5	F2, ALB, APOH, PIK3C2A, F8
38	epinephrine32 9 18 9	11.3	F2, CHKB, PIK3C2A, MB, F8, SLC17A5
39	iron32 18	9.2	SLC17A5, MB, F8, ALB, APOH, PIK3C2A
40	antipyrine32 9 9	10.2	F2, ALB, SLC17A5
41	superoxide32 18	9.2	TNF, APOH, CHKA, PIK3C2A, CHKB, SLC17A5
42	n acetylcysteine32	8.2	TNF, CHKA, CHKB, MB, SLC17A5, F2
43	cholesterol32 9 18 9	11.1	F8, ALB, PIK3C2A, APOH, CHKB, CHKA
44	simvastatin32 34 42 9 18 9	13.1	F2, TNF, SLC17A5, CHKA, CHKB, PIK3C2A
45	cyclosporin a32 42	8.9	F8, SLC17A5, TNF, F2, CHKB, PIK3C2A
46	prednisolone32 9 9	9.8	APOH, TNF, CHKB, PIK3C2A, ALB, F8
47	aspartate32	7.6	SLC17A5, ALB, F2, F8, MB, CHKB
48	methotrexate32 34 42 9 9	11.4	SLC17A5, PIK3C2A, ALB, TNF, CHKB, APOH
49	alanine32	7.3	SLC17A5, F2, F8, MB, CHKB, HELLS
50	lactate32	6.7	CHKA, CHKB, F8, MB, SLC17A5, TNF

Biological processes related to compartment syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylethanolamine biosynthetic process	GO:006646	10.0	CHKA, CHKB
2	positive regulation of blood coagulation	GO:030194	9.1	APOH, F2
3	blood coagulation, intrinsic pathway	GO:007597	9.0	APOH, F8, F2
4	negative regulation of fibrinolysis	GO:051918	8.9	APOH, F2

Molecular functions related to compartment syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ethanolamine kinase activity	GO:004305	10.0	CHKA, CHKB
2	choline kinase activity	GO:004103	9.7	CHKA, CHKB