MCID: CMP008
MIFTS: 56

Compartment Syndrome malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Compartment Syndrome

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Wikipedia:65 Compartment syndrome is increased pressure within one of the body\'s compartments which contains muscles... more...

MalaCards based summary: Compartment Syndrome, also known as compartmental syndrome, nos, is related to anuria and malignant hyperthermia. An important gene associated with Compartment Syndrome is CHKB (choline kinase beta), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and FOXA2 and FOXA3 transcription factor networks. The compounds kaolin and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related mouse phenotypes are muscle and growth/size/body.

Aliases & Classifications for Compartment Syndrome

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Compartment Syndrome, Aliases & Descriptions:

Name: Compartment Syndrome 8 42
Compartmental Syndrome, Nos 8 62
 
Compartment Syndromes 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:682
MeSH34 D003161
ICD9CM27 958.90

Related Diseases for Compartment Syndrome

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Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1anuria30.7MB
2malignant hyperthermia30.6PIK3C2A, MB
3calcinosis30.6PIK3C2A
4hellp syndrome30.4APOH, SLC17A5
5neuropathy30.4PIK3C2A, ALB, MB
6ectopic pregnancy30.4PIK3C2A, CHKB
7protein c deficiency30.3F2, APOH
8hypokalemia30.3MB, PIK3C2A
9myositis30.2PIK3C2A, CHKA, CHKB, MB, SLC17A5
10factor viii deficiency30.1F2, F8
11pulmonary embolism30.1ALB, APOH, F2
12hypothyroidism30.0PIK3C2A, CHKA, CHKB, F8
13ischemia30.0PIK3C2A, CHKA, CHKB, MB, SLC17A5
14rheumatoid arthritis29.9MB, CHKB, APOH, TNF
15hepatitis29.9F2, F8, SLC17A5
16venous thrombosis29.8MB, F8, APOH, LRP1, F2
17disseminated intravascular coagulation29.7F2, PIK3C2A, F8, MB
18systemic lupus erythematosus29.6F2, TNF, APOH, F8
19sepsis29.6F2, TNF, ALB
20diabetes mellitus29.6PIK3C2A, TNF, F8, ALB
21peritonitis29.6F2, TNF, ALB, MB
22vascular disease29.5MB, F8, APOH, TNF, PIK3C2A
23arthritis29.5MB, ALB, TNF
24anterior compartment syndrome10.8
25hypertension10.7
26retinal artery occlusion10.6APOH
27sneddon syndrome10.6APOH
28factor xii deficiency10.6APOH
29central retinal vein occlusion10.6APOH
30choledocholithiasis10.5SLC17A5
31retinal vasculitis10.5APOH
32aneurysm10.5
33legionnaires' disease10.5PIK3C2A
34capillary leak syndrome10.5
35erysipelas10.5PIK3C2A
36fascioliasis10.5SLC17A5
37gas gangrene10.5PIK3C2A
38status asthmaticus10.4PIK3C2A
39systemic capillary leak syndrome10.4
40dysphagia10.4PIK3C2A
41dysfibrinogenemia10.4F2
42acute pancreatitis10.4
43pancreatitis10.4
44hypersplenism10.4F2
45lymphangiosarcoma10.4F8
46pericardial effusion10.4PIK3C2A, CHKB
47abdominal aortic aneurysm10.4
48aortic aneurysm10.4
49cryoglobulinemia10.4APOH, SLC17A5
50myocarditis10.3MB, CHKB

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to compartment syndrome

Symptoms for Compartment Syndrome

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Drugs & Therapeutics for Compartment Syndrome

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Drug clinical trials:

Search ClinicalTrials for Compartment Syndrome

Search NIH Clinical Center for Compartment Syndrome

Genetic Tests for Compartment Syndrome

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Anatomical Context for Compartment Syndrome

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MalaCards organs/tissues related to Compartment Syndrome:

32
Bone, Kidney, Liver, Testes, Bone marrow, Skeletal muscle, Heart, Colon, Breast, Myeloid, Lung, Tongue

Animal Models for Compartment Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Compartment Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3LRP1, TNF, CHKB, ALB, MB
2MP:00053787.9SLC17A5, MB, TNF, LRP1, PIK3C2A, F2
3MP:00053977.5F2, PIK3C2A, LRP1, TNF, F8, MB
4MP:00107685.8TNF, LRP1, PIK3C2A, F2, APOH, CHKA
5MP:00053765.6SLC17A5, F2, PIK3C2A, LRP1, TNF, APOH

Publications for Compartment Syndrome

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Articles related to Compartment Syndrome:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Predictive factors of abdominal compartment syndrome in neonatal age. (23456905)
2014
2
Postinjury abdominal compartment syndrome: from recognition to prevention. (25390328)
2014
3
Acute compartment syndrome after intramedullary nailing of isolated radius and ulna fractures in children. (23812132)
2014
4
Abdominal compartment syndrome: Incidence and prognostic factors influencing survival in Singapore. (25316974)
2014
5
Abdominal compartment syndrome in severe acute pancreatitis treated with percutaneous catheter drainage. (25325011)
2014
6
Abdominal compartment syndrome - the prevention and treatment of possible lethal complications following hip arthroscopy: a case report. (25394557)
2014
7
Chronic exertional compartment syndrome of the leg in the military. (25280617)
2014
8
Upper arm compartment syndrome: a case report and review of the literature. (24002844)
2013
9
Upper limb compartment syndrome: An unusual complication of stroke thrombolysis. (24291484)
2013
10
Is surgery effective for deep posterior compartment syndrome of the leg? A systematic review. (24065078)
2013
11
Chronic exertional compartment syndrome of the forearm in elite rowers: a technique for mini-open fasciotomy and a report of six cases. (24426965)
2013
12
Paravertebral compartment syndrome after training causing severe back pain in an amateur rugby player: report of a rare case and review of the literature. (24004522)
2013
13
One elevated bladder pressure measurement may not be enough to diagnose abdominal compartment syndrome. (23336652)
2013
14
Orbital compartment syndrome following extracorporeal support. (23898881)
2013
15
Management of Chronic Exertional Compartment Syndrome and Fascial Hernias in the Anterior Lower Leg With the Forefoot Rise Test and Limited Fasciotomy. (24271459)
2013
16
Compartment syndrome as a spectrum of purple glove syndrome following intravenous phenytoin administration in a young male: a case report and review of literature. (24005736)
2013
17
Compartment syndrome of the hand from prolonged immobilization secondary to drug overdose. (23340119)
2013
18
Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. (23103728)
2013
19
Contrast enhanced ultrasound (CEUS) and time intensity curve (TIC) analysis in compartment syndrome: first results. (22538530)
2012
20
Forearm compartment syndrome owing to being stuck in the birth canal: a case report. (23164029)
2012
21
Abdominal compartment syndrome caused by tension pneumoperitoneum in a scuba diver. (23131212)
2012
22
Bilateral lower limb compartment syndrome: a potentially destructive complication of breast reduction. (22613285)
2012
23
Radiographic predictors of visual outcome in orbital compartment syndrome. (21946770)
2012
24
Acute paediatric compartment syndrome of the hand caused by hereditary angiooedema. (22004624)
2011
25
Lateral leg compartment syndrome caused by ill-fitting compression stocking placed for deep vein thrombosis prophylaxis during surgery: a case report. (21616687)
2011
26
What is the effect of compartment syndrome and fasciotomies on fracture healing in tibial fractures? (21993369)
2011
27
Abdominal compartment syndrome caused by massive pyonephrosis in an infant with primary obstructive megaureter. (21811507)
2011
28
Vascular-type Ehlers-Danlos syndrome presenting as recurrent compartment syndrome. (21982893)
2011
29
Abdominal Compartment Syndrome complicating massive hemorrhage from an unusual presentation of ruptured ectopic pregnancy. (21912014)
2011
30
Spontaneous thigh compartment syndrome. (21691491)
2011
31
A patient with abdominal compartment syndrome and perforated transverse colon successfully managed with ECMO. (22294070)
2011
32
Deltoid compartment syndrome is a surgical emergency. (20926313)
2010
33
Compartment syndrome as a complication of the lithotomy position. (21702244)
2010
34
Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. (20417482)
2010
35
Compartment syndrome of the foot secondary to fixation of ankle fracture--a case report. (20655005)
2010
36
Compartment syndrome after Bothrops jararaca snakebite: monitoring, treatment, and outcome. (20095815)
2010
37
Adder bite: an uncommon cause of compartment syndrome in northern hemisphere. (20854675)
2010
38
Interventional and surgical management of abdominal compartment syndrome in severe acute pancreatitis. (20571292)
2010
39
Acute compartment syndrome of the forearm and hand in a patient of spine surgery -A case report-. (20652000)
2010
40
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
41
Revision surgery for exertional anterior compartment syndrome of the lower leg: technique, findings, and results. (15888718)
2005
42
Desflurane, malignant hyperthermia, and release of compartment syndrome. (15845684)
2005
43
Multifocal streptococcal pyomyositis complicated by acute compartment syndrome: case report. (11360777)
2001
44
Compartment syndrome in both lower legs after prolonged surgery in the lithotomy position]. (9627455)
1998
45
Treatment of chronic exertional anterior compartment syndrome with massage: a pilot study. (9448951)
1998
46
Anterior dissection of popliteal cyst causing anterior compartment syndrome. (7562776)
1995
47
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
48
The anterior compartment syndrome in the lower leg. Review and role of the EMG examination. (2097862)
1990
49
Diagnosis of chronic anterior compartment syndrome in the lower leg. (3604630)
1987
50
Neglected acute post exertional anterior compartment syndrome: a case report. (3842737)
1985

Variations for Compartment Syndrome

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Expression for genes affiliated with Compartment Syndrome

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Expression patterns in normal tissues for genes affiliated with Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for genes affiliated with Compartment Syndrome

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Pathways related to Compartment Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6F8, F2
29.5ALB, F2
39.5TNF, LRP1
49.2ALB, F8, APOH
5
Show member pathways
thioredoxin pathway37
8.9ALB, TNF, F2
6
Show member pathways
8.8PIK3C2A, CHKA, CHKB

Compounds for genes affiliated with Compartment Syndrome

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Compounds related to Compartment Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1kaolin449.5F2, F8, APOH
2alpha-hydroxybutyrate449.4CHKB, SLC17A5, MB, PIK3C2A
3hepaplastin449.4SLC17A5, ALB, F2
4succinylcholine44 50 28 1112.4SLC17A5, MB, PIK3C2A, CHKB
5bezafibrate44 28 1111.3PIK3C2A, CHKB, SLC17A5, MB
6dantrolene28 44 1111.1PIK3C2A, CHKB, MB
7vitamin b12449.0APOH, ALB, MB, SLC17A5
8hydroxyethyl starch449.0ALB, F2, F8
9cocaine44 1110.0MB, CHKB, APOH, SLC17A5, PIK3C2A
10halothane44 50 28 1111.9ALB, MB, CHKB, SLC17A5, PIK3C2A
11phosphocreatine44 249.9CHKA, PIK3C2A, CHKB, MB
12melphalan44 50 1110.9CHKB, PIK3C2A, TNF, MB
13pge1448.8APOH, PIK3C2A, F2, SLC17A5
14endotoxin448.7CHKB, F8, APOH, SLC17A5, TNF
15warfarin44 50 24 1111.6PIK3C2A, ALB, F8, F2, APOH
16homocysteine44 249.6F2, ALB, F8, APOH, PIK3C2A
17alpha tocopherol448.6APOH, CHKA, ALB, CHKB, MB
18polyethylene glycol448.6SLC17A5, MB, ALB, F8, CHKB, F2
19malondialdehyde448.5SLC17A5, APOH, CHKA, CHKB, PIK3C2A
20epinephrine44 24 1110.5CHKB, F8, SLC17A5, MB, F2, PIK3C2A
21ivig448.4PIK3C2A, ALB, F8, APOH, TNF
22polyacrylamide448.4SLC17A5, CHKB, APOH, CHKA, F8
23phosphatidylcholine448.4MB, F2, F8, CHKA, APOH
24urea44 24 1110.3PIK3C2A, CHKA, ALB, CHKB, SLC17A5
25iron44 249.3APOH, F8, ALB, PIK3C2A, SLC17A5, MB
26atorvastatin44 50 28 24 1112.2CHKB, CHKA, PIK3C2A, SLC17A5, TNF
27cyclosporin a44 28 6110.1PIK3C2A, SLC17A5, F8, CHKB, TNF, F2
28phosphorus448.1PIK3C2A, APOH, CHKA, CHKB, ALB, SLC17A5
29thyroxine44 249.1SLC17A5, MB, ALB, CHKB, CHKA, PIK3C2A
30uric acid44 249.1CHKA, APOH, SLC17A5, PIK3C2A, CHKB, ALB
31n acetylcysteine448.0CHKB, CHKA, SLC17A5, MB, TNF, F2
32ascorbic acid44 249.0CHKA, PIK3C2A, ALB, MB, SLC17A5, CHKB
33vegf447.9LRP1, F8, CHKB, APOH, TNF, PIK3C2A
34simvastatin44 50 61 28 24 1112.9TNF, PIK3C2A, F2, CHKA, CHKB, SLC17A5
35methotrexate50 44 119.9PIK3C2A, F2, SLC17A5, TNF, APOH, ALB
36superoxide44 248.8APOH, SLC17A5, CHKB, CHKA, TNF, PIK3C2A
37fatty acid447.7ALB, CHKA, APOH, LRP1, PIK3C2A, SLC17A5
38testosterone44 61 24 1110.7SLC17A5, MB, PIK3C2A, CHKB, CHKA, ALB
39citrate447.6CHKB, F8, MB, CHKA, PIK3C2A, F2
40prednisolone44 28 119.5ALB, TNF, PIK3C2A, SLC17A5, MB, F8
41oxygen44 248.5MB, SLC17A5, CHKB, CHKA, APOH, TNF
42fibrinogen447.4SLC17A5, ALB, F8, CHKB, APOH, PIK3C2A
43heparin44 28 24 1110.4MB, ALB, F8, CHKB, LRP1, PIK3C2A
44cholesterol44 28 24 1110.3F8, SLC17A5, CHKB, ALB, CHKA, APOH
45glucose447.2CHKA, CHKB, F8, ALB, PIK3C2A, LRP1
46alanine447.2PIK3C2A, SLC17A5, MB, F8, CHKB, ALB
47creatinine446.9F8, CHKB, CHKA, PIK3C2A, F2, APOH
48aspartate446.9SLC17A5, ALB, MB, LRP1, F8, CHKB
49lipid446.8ALB, F8, CHKA, APOH, PIK3C2A, TNF
50lactate446.3F2, CHKA, CHKB, F8, ALB, MB

GO Terms for genes affiliated with Compartment Syndrome

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Cellular components related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, F8
2clathrin-coated vesicleGO:0301369.3LRP1, PIK3C2A
3extracellular spaceGO:0056158.0ALB, F8, APOH, TNF, F2

Biological processes related to Compartment Syndrome according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.9APOH, F2
2positive regulation of blood coagulationGO:0301949.9APOH, F2
3positive regulation of protein transportGO:0512229.7TNF, LRP1
4lipoprotein metabolic processGO:0421579.6ALB, LRP1
5CDP-choline pathwayGO:0066579.6CHKA, CHKB
6blood coagulation, intrinsic pathwayGO:0075979.5F8, APOH, F2
7phosphatidylethanolamine biosynthetic processGO:0066469.5CHKA, CHKB
8acute-phase responseGO:0069539.3F8, F2
9phosphatidylcholine biosynthetic processGO:0066569.3CHKB, CHKA
10platelet activationGO:0301689.1F2, F8, ALB
11phospholipid metabolic processGO:0066448.9CHKB, CHKA, PIK3C2A

Molecular functions related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen bindingGO:0198259.7MB, ALB
2choline kinase activityGO:0041039.3CHKB, CHKA
3ethanolamine kinase activityGO:0043059.1CHKB, CHKA

Products for genes affiliated with Compartment Syndrome

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Sources for Compartment Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet