MCID: CMP008
MIFTS: 51

Compartment Syndrome malady

Summaries for Compartment Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Compartment syndrome is a life-threatening condition of the limbs which occurs after an injury, when... more...

MalaCards: Compartment Syndrome, also known as compartment syndromes, is related to hypertension and acute pancreatitis. An important gene associated with Compartment Syndrome is CHKB (choline kinase beta), and among its related pathways are Selected targets of HNF1 and Selenium Pathway. The compounds warfarin and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and testes, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Compartment Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

compartment syndrome 8 42
compartment syndromes 44 60
compartmental syndrome, nos 8


External Ids:

Disease Ontology8 DOID:682
ICD9CM27 958.90
MeSH34 D003161

Related Diseases for Compartment Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9ALB, F2
2acute pancreatitis30.5SLC17A5, MB
3pancreatitis30.5SLC17A5, ALB
4neuropathy30.2ALB, PIK3C2A, MB
5myositis30.2MB, PIK3C2A, CHKA, CHKB, SLC17A5
6malignant hyperthermia30.0PIK3C2A, MB
7hypothyroidism30.0F8, PIK3C2A, CHKA, CHKB
8ischemia30.0MB, PIK3C2A, CHKA, CHKB, SLC17A5
9pulmonary embolism30.0ALB, F2, APOH
10diabetes mellitus30.0TNF, F8, PIK3C2A, ALB
11anuria29.8MB
12hellp syndrome29.8SLC17A5, APOH
13hypokalemia29.8PIK3C2A, MB
14thrombocytosis29.8F2
15ovarian hyperstimulation syndrome29.8ALB
16intracranial hypertension29.8ALB
17hepatitis a29.8F8, F2
18lupus erythematosus29.8F2, APOH
19protein c deficiency29.8F2, APOH
20sarcoma29.8HELLS, MB, F8
21toxic shock syndrome29.8TNF
22hemorrhagic disease29.8F8, F2
23disseminated intravascular coagulation29.8MB, F8, PIK3C2A, F2
24factor viii deficiency29.8F8, F2
25leukemia29.8F8, TNF, HELLS
26hepatitis29.8F2, SLC17A5, ALB
27rheumatoid arthritis29.8CHKB, APOH, TNF, MB
28arthritis29.8ALB, TNF, MB
29vascular disease29.8MB, TNF, APOH, F8, PIK3C2A
30systemic lupus erythematosus29.8F2, F8, APOH, TNF
31peritonitis29.8MB, TNF, F2, ALB
32anterior compartment syndrome10.8
33capillary leak syndrome10.4
34abdominal aortic aneurysm10.3
35aortic aneurysm10.3
36ruptured abdominal aortic aneurysm10.3
37ruptured aortic aneurysm10.3
38pyomyositis10.2
39burns10.1
40cystadenoma10.1
41adult syndrome10.1
42megacolon10.1
43ovarian cystadenoma10.1
44arteriovenous fistula10.0
45toxic megacolon10.0
46sciatic neuropathy10.0
47mucinous ovarian cystadenoma10.0
48cerebritis10.0
49dengue hemorrhagic fever10.0
50volkmann contracture10.0

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to compartment syndrome

Clinical Features for Compartment Syndrome

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Drugs & Therapeutics for Compartment Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Compartment Syndrome

Drug clinical trials:

Search ClinicalTrials for Compartment Syndrome

Search NIH Clinical Center for Compartment Syndrome

Search CenterWatch for Compartment Syndrome

Genetic Tests for Compartment Syndrome

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Anatomical Context for Compartment Syndrome

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32MalaCards
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MalaCards organs/tissues related to Compartment Syndrome:

32
Bone, Liver, Testes, Bone marrow, Kidney, Colon, Skeletal muscle, Breast, Heart, Myeloid, B cells, Tongue, T cells, Lung, Fetal liver

Animal Models for Compartment Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Compartment Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.8HELLS, SLC17A5, F2, LRP1, CHKA, PIK3C2A
2MP:00053766.3HELLS, F2, LRP1, CHKB, CHKA, PIK3C2A

Publications for Compartment Syndrome

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Sources:
50PubMed
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Articles related to Compartment Syndrome:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
The conjoint effect of reduced crystalloid administration and decreased damage-control laparotomy use in the development of abdominal compartment syndrome. (24398772)
2014
2
Paravertebral compartment syndrome after training causing severe back pain in an amateur rugby player: report of a rare case and review of the literature. (24004522)
2013
3
Compartment syndrome of the hand from prolonged immobilization secondary to drug overdose. (23340119)
2013
4
Abdominal compartment syndrome after laparoscopic Roux-en-Y gastric bypass: a case report. (22516233)
2013
5
A collaborative system to improve compartment syndrome recognition. (24218466)
2013
6
Compartment syndrome performance improvement project is associated with increased combat casualty survival. (23147175)
2013
7
Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. (24369837)
2013
8
Gluteal Compartment Syndrome following an Iliac Bone Marrow Aspiration. (24392235)
2013
9
A novel nonoperative approach to abdominal compartment syndrome after abdominal wall reconstruction. (24018095)
2013
10
Management of complex extremity injuries: tourniquets, compartment syndrome detection, fasciotomy, and amputation care. (22850158)
2012
11
Bilateral compartment syndrome of the anterior thigh following functional fitness exercises: a case report. (22934383)
2012
12
Acute lower extremity compartment syndrome: avoiding limb loss and long-term complications. (22530548)
2012
13
Protein C deficiency with concurrent essential thrombocytosis and orbital compartment syndrome. (21718414)
2012
14
Surgical management of closed crush injury-induced compartment syndrome after earthquakes in resource-scarce settings. (22710766)
2012
15
Fulminant and fatal course of acute lymphoblastic leukemia due to lactic acidosis and suspected abdominal compartment syndrome. (22134616)
2012
16
Abdominal compartment syndrome in children. (23203955)
2012
17
Spontaneous thigh compartment syndrome. (21691491)
2011
18
Current recognition and management of intra-abdominal hypertension and abdominal compartment syndrome among tertiary Chinese intensive care physicians. (21265048)
2011
19
Compartment syndrome as a rare complication of iloprost infusion for peripheral vascular disease. (21549925)
2011
20
Injection anthrax causing compartment syndrome and necrotising fasciitis. (21097792)
2011
21
Abdominal compartment syndrome: potentially lethal and easy to miss. (21905464)
2011
22
Compartment syndrome of the upper extremity. (21371631)
2011
23
Too many platelets to cause compartment syndrome. (20923789)
2011
24
Compartment syndrome following lower limb arthroplasty: a review. (21686323)
2011
25
Open versus closed abdomen treatment on liver function in rats with sepsis and abdominal compartment syndrome. (22071931)
2011
26
Pediatric compartment syndrome following an insect bite: a case report. (22942862)
2011
27
Acute compartment syndrome in children: a case series in 24 patients and review of the literature. (20401657)
2011
28
Compartment syndrome in all four extremities: a rare case associated with systemic capillary leak syndrome. (22379451)
2011
29
Acute compartment syndrome in a patient on extracorporeal support: utility of near-infrared spectroscopy. (20832334)
2011
30
Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. (20417482)
2010
31
Understanding of Abdominal Compartment Syndrome among Pediatric Healthcare Providers. (20981270)
2010
32
Life threatening intraperitoneal hemorrhage with abdominal compartment syndrome: unusual presentation of renal angiomyolipoma. (20727054)
2010
33
Bilateral gluteal pain caused by piriformis muscle compartment syndrome in the greater sciatic foramen: a case report. (20454823)
2010
34
Endoscopic-assisted Fascial Decompression for Forearm Exertional Compartment Syndrome: A Case Report and Review of the Literature. (22131927)
2010
35
Acute compartment syndrome of the forearm caused by calcific tendinitis of the distal biceps. (20936391)
2010
36
Foot drop--an unusual presentation of exertional compartment syndrome. (19423978)
2009
37
Leg anterior compartment syndrome following ankle arthroscopy after Maisonneuve fracture. (19171284)
2009
38
Unusual complications of heroin abuse: transverse myelitis, rhabdomyolysis, compartment syndrome, and ARF. (17917867)
2008
39
Revision surgery for exertional anterior compartment syndrome of the lower leg: technique, findings, and results. (15888718)
2005
40
Acute ischemic optic neuropathy associated with an abdominal compartment syndrome in a burn patient. (15225919)
2004
41
Anterior compartment syndrome following an Achilles tendon repair: an unusual complication. (15273530)
2004
42
Acute anterior compartment syndrome of the forearm following lifting a heavy load. (10704591)
2000
43
Systemic capillary leak syndrome associated with rhabdomyolysis and compartment syndrome. (10597109)
1999
44
Compartment syndrome in both lower legs after prolonged surgery in the lithotomy position]. (9627455)
1998
45
Acute renal failure, compartment syndrome, and systemic capillary leak syndrome complicating carbon monoxide poisoning. (8941202)
1996
46
Postoperative bilateral compartment syndrome resulting from prolonged urological surgery in lithotomy position. Serum creatine kinase activity (CK) as a warning signal in sedated, artificially respirated patients]. (7695079)
1995
47
Spontaneous gluteal artery rupture resulting in compartment syndrome and sciatic neuropathy. Report of a case in Ehlers-Danlos syndrome. (1735223)
1992
48
Analysis of the peripheral T-cell compartment in the MHC class II deficiency syndrome. (1796210)
1991
49
Recurrent compartment syndrome and Volkmann contracture associated with chronic osteomyelitis of the ulna. A case report. (2295662)
1990
50
Ischemic necrosis of muscle (acute anterior compartment syndrome) following repair of anterior compartment muscle hernias. (5249530)
1968

Genetic Variations for Compartment Syndrome

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Expression for genes affiliated with Compartment Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Compartment Syndrome

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Pathways for genes affiliated with Compartment Syndrome

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Sources:
12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Compartment Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ALB, F8, APOH
29.6ALB, F2, TNF

Compounds for genes affiliated with Compartment Syndrome

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Compartment Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.2PIK3C2A, APOH
2alpha tocopherol4410.0APOH, CHKA, CHKB
3kaolin4410.0APOH, F2, F8
4Coagulation Factor IX1110.0LRP1, F2, F8
5hepaplastin4410.0ALB, SLC17A5, F2
6hydroxyethyl starch449.9ALB, F2, F8
7dantrolene44 28 1111.9PIK3C2A, MB, CHKB
8alpha-hydroxybutyrate449.8SLC17A5, PIK3C2A, MB, CHKB
9succinylcholine44 28 1111.8MB, PIK3C2A, CHKB, SLC17A5
10bezafibrate44 28 1111.7MB, PIK3C2A, CHKB, SLC17A5
11uric acid44 2410.7CHKA, APOH, CHKB, PIK3C2A
12gamma-hydroxybutyrate449.6CHKB, PIK3C2A, MB
13phosphocreatine44 2410.6CHKA, PIK3C2A, CHKB, MB
14heparin44 28 11 2412.6MB, F8, APOH, PIK3C2A, CHKB
15vitamin b12449.6MB, ALB, APOH, SLC17A5
16melphalan44 1110.5PIK3C2A, CHKB, MB, TNF
17halothane44 28 1111.5MB, SLC17A5, CHKB, PIK3C2A, ALB
18endotoxin449.5TNF, APOH, F8, CHKB, SLC17A5
19cocaine44 1110.4SLC17A5, MB, APOH, PIK3C2A, CHKB
20polyethylene glycol449.4SLC17A5, F2, MB, F8, CHKB, ALB
21ivig449.4PIK3C2A, APOH, TNF, ALB, F8
22malondialdehyde449.4SLC17A5, CHKB, PIK3C2A, APOH, CHKA
23homocysteine44 2410.3APOH, F8, F2, PIK3C2A, ALB
24phosphatidylcholine449.3F2, APOH, F8, CHKA, MB
25pge1449.3APOH, F2, SLC17A5, PIK3C2A
26atorvastatin44 49 28 11 2413.2TNF, PIK3C2A, SLC17A5, CHKB, CHKA
27urea44 11 2411.2ALB, SLC17A5, CHKB, CHKA, PIK3C2A
28epinephrine44 11 2411.2F8, PIK3C2A, MB, CHKB, F2, SLC17A5
29n acetylcysteine449.2CHKB, MB, TNF, CHKA, SLC17A5, F2
30phosphorus449.1ALB, PIK3C2A, SLC17A5, CHKA, CHKB, APOH
31thyroxine44 2410.1MB, ALB, PIK3C2A, CHKA, CHKB, SLC17A5
32ascorbic acid44 2410.0MB, PIK3C2A, CHKB, SLC17A5, CHKA, ALB
33simvastatin44 49 59 28 11 2414.0F2, PIK3C2A, CHKA, TNF, CHKB, SLC17A5
34cyclosporin a44 28 5911.0F2, F8, SLC17A5, PIK3C2A, TNF, CHKB
35iron44 249.9ALB, F8, APOH, PIK3C2A, MB, SLC17A5
36polyacrylamide448.9CHKB, CHKA, SLC17A5, F8, APOH, HELLS
37citrate448.9CHKB, F8, ALB, F2, MB, CHKA
38methotrexate44 49 1110.9APOH, PIK3C2A, CHKB, F2, TNF, ALB
39superoxide44 249.7CHKA, CHKB, SLC17A5, APOH, TNF
40prednisolone44 28 1110.7ALB, APOH, TNF, MB, F8, PIK3C2A
41fatty acid448.7CHKA, PIK3C2A, CHKB, LRP1, ALB, APOH
42fibrinogen448.6PIK3C2A, APOH, F8, TNF, CHKB, ALB
43lysine448.5CHKA, CHKB, LRP1, APOH, HELLS, F8
44aspartate448.5F8, CHKB, F2, LRP1, SLC17A5, ALB
45cholesterol44 28 11 2411.5ALB, CHKB, PIK3C2A, CHKA, SLC17A5, F8
46vegf448.4TNF, LRP1, CHKB, PIK3C2A, APOH, MB
47creatinine448.4SLC17A5, F2, CHKB, CHKA, ALB, PIK3C2A
48glucose448.4ALB, LRP1, APOH, SLC17A5, CHKA, CHKB
49lactate448.1ALB, SLC17A5, F2, CHKB, MB, CHKA
50alanine448.0ALB, MB, HELLS, PIK3C2A, SLC17A5, F2

GO Terms for genes affiliated with Compartment Syndrome

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16Gene Ontology
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Biological processes related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CDP-choline pathwayGO:0066579.9CHKB, CHKA
2phosphatidylethanolamine biosynthetic processGO:0066469.9CHKA, CHKB
3negative regulation of fibrinolysisGO:0519189.8F2, APOH
4blood coagulation, intrinsic pathwayGO:0075979.8F8, F2, APOH
5positive regulation of blood coagulationGO:0301949.6F2, APOH

Molecular functions related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ethanolamine kinase activityGO:0043059.9CHKB, CHKA
2choline kinase activityGO:0041039.6CHKB, CHKA

Products for genes affiliated with Compartment Syndrome

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  • Antibodies
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Sources for Compartment Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet