MCID: CMP008
MIFTS: 56

Compartment Syndrome malady

Rare diseases, Cardiovascular diseases categories

Summaries for Compartment Syndrome

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Compartment syndrome is a life-threatening condition of the limbs which occurs after an injury, when... more...

MalaCards: Compartment Syndrome, also known as compartment syndromes, is related to neuropathy and myositis. An important gene associated with Compartment Syndrome is CHKB (choline kinase beta), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and FOXA2 and FOXA3 transcription factor networks. The compounds kaolin and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are muscle and growth/size/body.

Aliases & Classifications for Compartment Syndrome

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

compartment syndrome 9 44
compartment syndromes 46 63
compartmental syndrome, nos 9


External Ids:

Disease Ontology9 DOID:682
ICD9CM28 958.90
MeSH36 D003161

Related Diseases for Compartment Syndrome

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.3MB, ALB, PIK3C2A
2myositis30.3CHKA, PIK3C2A, CHKB, MB, SLC17A5
3malignant hyperthermia30.2PIK3C2A, MB
4pulmonary embolism30.1F2, APOH, ALB
5hypothyroidism30.1CHKB, F8, CHKA, PIK3C2A
6anuria30.1MB
7ischemia30.1CHKB, MB, SLC17A5, CHKA, PIK3C2A
8calcinosis30.0PIK3C2A
9venous thrombosis30.0MB, F8, APOH, LRP1, F2
10hellp syndrome30.0SLC17A5, APOH
11ectopic pregnancy30.0CHKB, PIK3C2A
12protein c deficiency30.0F2, APOH
13hypokalemia30.0MB, PIK3C2A
14diabetes mellitus30.0F8, TNF, PIK3C2A, ALB
15factor viii deficiency29.9F2, F8
16rheumatoid arthritis29.9APOH, TNF, MB, CHKB
17hepatitis29.9F8, F2, SLC17A5
18disseminated intravascular coagulation29.8PIK3C2A, F8, MB, F2
19systemic lupus erythematosus29.8APOH, F8, TNF, F2
20sepsis29.8ALB, F2, TNF
21peritonitis29.8ALB, TNF, MB, F2
22vascular disease29.8MB, F8, APOH, TNF, PIK3C2A
23arthritis29.8ALB, MB, TNF
24anterior compartment syndrome10.8
25hypertension10.7
26aneurysm10.5
27capillary leak syndrome10.4
28systemic capillary leak syndrome10.4
29acute pancreatitis10.4
30pancreatitis10.4
31abdominal aortic aneurysm10.3
32aortic aneurysm10.3
33pyomyositis10.3
34burns10.2
35cystadenoma10.2
36megacolon10.2
37back pain10.2
38retinal artery occlusion10.1APOH
39sneddon syndrome10.1APOH
40factor xii deficiency10.1APOH
41central retinal vein occlusion10.1APOH
42choledocholithiasis10.1SLC17A5
43retinal vasculitis10.1APOH
44legionnaires' disease10.1PIK3C2A
45erysipelas10.1PIK3C2A
46fascioliasis10.1SLC17A5
47gas gangrene10.1PIK3C2A
48status asthmaticus10.1PIK3C2A
49dysphagia10.1PIK3C2A
50dysfibrinogenemia10.1F2

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to compartment syndrome

Symptoms for Compartment Syndrome

About this section

Drugs & Therapeutics for Compartment Syndrome

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Compartment Syndrome

Drug clinical trials:

Search ClinicalTrials for Compartment Syndrome

Search NIH Clinical Center for Compartment Syndrome

Search CenterWatch for Compartment Syndrome

Genetic Tests for Compartment Syndrome

About this section

Anatomical Context for Compartment Syndrome

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Compartment Syndrome:

34
Liver, Bone, Testes, Bone marrow, Kidney, Colon, Skeletal muscle, Breast, Heart, Lung, Myeloid, Tongue

Animal Models for Compartment Syndrome or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Compartment Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3LRP1, TNF, CHKB, ALB, MB
2MP:00053787.9SLC17A5, MB, TNF, LRP1, PIK3C2A, F2
3MP:00053977.5F2, PIK3C2A, LRP1, TNF, F8, MB
4MP:00107685.8TNF, LRP1, PIK3C2A, F2, APOH, CHKA
5MP:00053765.6SLC17A5, F2, PIK3C2A, LRP1, TNF, APOH

Publications for Compartment Syndrome

About this section
Sources:
53PubMed
See all sources

Articles related to Compartment Syndrome:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Predictive factors of abdominal compartment syndrome in neonatal age. (23456905)
2014
2
Acute compartment syndrome after intramedullary nailing of isolated radius and ulna fractures in children. (23812132)
2014
3
Upper arm compartment syndrome: a case report and review of the literature. (24002844)
2013
4
Upper limb compartment syndrome: An unusual complication of stroke thrombolysis. (24291484)
2013
5
Is surgery effective for deep posterior compartment syndrome of the leg? A systematic review. (24065078)
2013
6
Chronic exertional compartment syndrome of the forearm in elite rowers: a technique for mini-open fasciotomy and a report of six cases. (24426965)
2013
7
Paravertebral compartment syndrome after training causing severe back pain in an amateur rugby player: report of a rare case and review of the literature. (24004522)
2013
8
One elevated bladder pressure measurement may not be enough to diagnose abdominal compartment syndrome. (23336652)
2013
9
Orbital compartment syndrome following extracorporeal support. (23898881)
2013
10
Management of Chronic Exertional Compartment Syndrome and Fascial Hernias in the Anterior Lower Leg With the Forefoot Rise Test and Limited Fasciotomy. (24271459)
2013
11
Compartment syndrome as a spectrum of purple glove syndrome following intravenous phenytoin administration in a young male: a case report and review of literature. (24005736)
2013
12
Compartment syndrome of the hand from prolonged immobilization secondary to drug overdose. (23340119)
2013
13
Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. (23103728)
2013
14
Gluteal compartment syndrome with severe rhabdomyolysis. (23933861)
2013
15
Contrast enhanced ultrasound (CEUS) and time intensity curve (TIC) analysis in compartment syndrome: first results. (22538530)
2012
16
Forearm compartment syndrome owing to being stuck in the birth canal: a case report. (23164029)
2012
17
Abdominal compartment syndrome caused by tension pneumoperitoneum in a scuba diver. (23131212)
2012
18
Bilateral lower limb compartment syndrome: a potentially destructive complication of breast reduction. (22613285)
2012
19
Radiographic predictors of visual outcome in orbital compartment syndrome. (21946770)
2012
20
Compartment syndrome in dislocation and non-dislocation type proximal tibia fractures: analysis of 356 consecutive cases. (21997400)
2012
21
Lower extremity anterior compartment syndrome complicating bilateral mastectomy and immediate breast reconstruction: A case report and literature review. (23730157)
2012
22
Why hyperbaric oxygen therapy may be useful in treating crush injuries and skeletal muscle-compartment syndrome. (22908835)
2012
23
Acute paediatric compartment syndrome of the hand caused by hereditary angiooedema. (22004624)
2011
24
Lateral leg compartment syndrome caused by ill-fitting compression stocking placed for deep vein thrombosis prophylaxis during surgery: a case report. (21616687)
2011
25
What is the effect of compartment syndrome and fasciotomies on fracture healing in tibial fractures? (21993369)
2011
26
Abdominal compartment syndrome caused by massive pyonephrosis in an infant with primary obstructive megaureter. (21811507)
2011
27
Vascular-type Ehlers-Danlos syndrome presenting as recurrent compartment syndrome. (21982893)
2011
28
Abdominal Compartment Syndrome complicating massive hemorrhage from an unusual presentation of ruptured ectopic pregnancy. (21912014)
2011
29
Spontaneous thigh compartment syndrome. (21691491)
2011
30
A patient with abdominal compartment syndrome and perforated transverse colon successfully managed with ECMO. (22294070)
2011
31
Deltoid compartment syndrome is a surgical emergency. (20926313)
2010
32
Compartment syndrome as a complication of the lithotomy position. (21702244)
2010
33
Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. (20417482)
2010
34
Compartment syndrome of the foot secondary to fixation of ankle fracture--a case report. (20655005)
2010
35
Compartment syndrome after Bothrops jararaca snakebite: monitoring, treatment, and outcome. (20095815)
2010
36
Adder bite: an uncommon cause of compartment syndrome in northern hemisphere. (20854675)
2010
37
Interventional and surgical management of abdominal compartment syndrome in severe acute pancreatitis. (20571292)
2010
38
Acute compartment syndrome of the forearm and hand in a patient of spine surgery -A case report-. (20652000)
2010
39
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
40
Revision surgery for exertional anterior compartment syndrome of the lower leg: technique, findings, and results. (15888718)
2005
41
Desflurane, malignant hyperthermia, and release of compartment syndrome. (15845684)
2005
42
Multifocal streptococcal pyomyositis complicated by acute compartment syndrome: case report. (11360777)
2001
43
Compartment syndrome in both lower legs after prolonged surgery in the lithotomy position]. (9627455)
1998
44
Treatment of chronic exertional anterior compartment syndrome with massage: a pilot study. (9448951)
1998
45
Anterior dissection of popliteal cyst causing anterior compartment syndrome. (7562776)
1995
46
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
47
Cyclosporin-associated rhabdomyolysis and anterior compartment syndrome in a renal transplant recipient. (8334764)
1993
48
The anterior compartment syndrome in the lower leg. Review and role of the EMG examination. (2097862)
1990
49
Diagnosis of chronic anterior compartment syndrome in the lower leg. (3604630)
1987
50
Neglected acute post exertional anterior compartment syndrome: a case report. (3842737)
1985

Variations for Compartment Syndrome

About this section

Expression for genes affiliated with Compartment Syndrome

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for genes affiliated with Compartment Syndrome

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 13EMD Millipore, 31KEGG
See all sources

Pathways related to Compartment Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6F8, F2
29.5ALB, F2
39.5TNF, LRP1
49.2ALB, F8, APOH
5
Show member pathways
thioredoxin pathway39
8.9ALB, TNF, F2
6
Show member pathways
8.8PIK3C2A, CHKA, CHKB

Compounds for genes affiliated with Compartment Syndrome

About this section
Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience
See all sources

Compounds related to Compartment Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1kaolin469.5F2, F8, APOH
2alpha-hydroxybutyrate469.4CHKB, SLC17A5, MB, PIK3C2A
3hepaplastin469.4SLC17A5, ALB, F2
4succinylcholine46 52 30 1212.4SLC17A5, MB, PIK3C2A, CHKB
5bezafibrate46 30 1211.3PIK3C2A, CHKB, SLC17A5, MB
6dantrolene30 46 1211.1PIK3C2A, CHKB, MB
7vitamin b12469.0APOH, ALB, MB, SLC17A5
8hydroxyethyl starch469.0ALB, F2, F8
9cocaine46 1210.0MB, CHKB, APOH, SLC17A5, PIK3C2A
10halothane46 52 30 1211.9ALB, MB, CHKB, SLC17A5, PIK3C2A
11phosphocreatine46 259.9CHKA, PIK3C2A, CHKB, MB
12melphalan46 52 1210.9CHKB, PIK3C2A, TNF, MB
13pge1468.8APOH, PIK3C2A, F2, SLC17A5
14endotoxin468.7CHKB, F8, APOH, SLC17A5, TNF
15warfarin46 52 25 1211.6PIK3C2A, ALB, F8, F2, APOH
16homocysteine46 259.6F2, ALB, F8, APOH, PIK3C2A
17alpha tocopherol468.6APOH, CHKA, ALB, CHKB, MB
18polyethylene glycol468.6SLC17A5, MB, ALB, F8, CHKB, F2
19malondialdehyde468.5SLC17A5, APOH, CHKA, CHKB, PIK3C2A
20epinephrine46 25 1210.5CHKB, F8, SLC17A5, MB, F2, PIK3C2A
21ivig468.4PIK3C2A, ALB, F8, APOH, TNF
22polyacrylamide468.4SLC17A5, CHKB, APOH, CHKA, F8
23phosphatidylcholine468.4MB, F2, F8, CHKA, APOH
24urea46 25 1210.3PIK3C2A, CHKA, ALB, CHKB, SLC17A5
25iron46 259.3APOH, F8, ALB, PIK3C2A, SLC17A5, MB
26atorvastatin46 52 30 25 1212.2CHKB, CHKA, PIK3C2A, SLC17A5, TNF
27cyclosporin a46 30 6210.1PIK3C2A, SLC17A5, F8, CHKB, TNF, F2
28phosphorus468.1PIK3C2A, APOH, CHKA, CHKB, ALB, SLC17A5
29thyroxine46 259.1SLC17A5, MB, ALB, CHKB, CHKA, PIK3C2A
30uric acid46 259.1CHKA, APOH, SLC17A5, PIK3C2A, CHKB, ALB
31n acetylcysteine468.0CHKB, CHKA, SLC17A5, MB, TNF, F2
32ascorbic acid46 259.0CHKA, PIK3C2A, ALB, MB, SLC17A5, CHKB
33vegf467.9LRP1, F8, CHKB, APOH, TNF, PIK3C2A
34simvastatin46 52 62 30 25 1212.9TNF, PIK3C2A, F2, CHKA, CHKB, SLC17A5
35methotrexate52 46 129.9PIK3C2A, F2, SLC17A5, TNF, APOH, ALB
36superoxide46 258.8APOH, SLC17A5, CHKB, CHKA, TNF, PIK3C2A
37fatty acid467.7ALB, CHKA, APOH, LRP1, PIK3C2A, SLC17A5
38testosterone46 62 25 1210.7SLC17A5, MB, PIK3C2A, CHKB, CHKA, ALB
39citrate467.6CHKB, F8, MB, CHKA, PIK3C2A, F2
40prednisolone46 30 129.5ALB, TNF, PIK3C2A, SLC17A5, MB, F8
41oxygen46 258.5MB, SLC17A5, CHKB, CHKA, APOH, TNF
42fibrinogen467.4SLC17A5, ALB, F8, CHKB, APOH, PIK3C2A
43heparin46 30 25 1210.4MB, ALB, F8, CHKB, LRP1, PIK3C2A
44cholesterol46 30 25 1210.3F8, SLC17A5, CHKB, ALB, CHKA, APOH
45glucose467.2CHKA, CHKB, F8, ALB, PIK3C2A, LRP1
46alanine467.2PIK3C2A, SLC17A5, MB, F8, CHKB, ALB
47creatinine466.9F8, CHKB, CHKA, PIK3C2A, F2, APOH
48aspartate466.9SLC17A5, ALB, MB, LRP1, F8, CHKB
49lipid466.8ALB, F8, CHKA, APOH, PIK3C2A, TNF
50lactate466.3F2, CHKA, CHKB, F8, ALB, MB

GO Terms for genes affiliated with Compartment Syndrome

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, F8
2clathrin-coated vesicleGO:0301369.3LRP1, PIK3C2A
3extracellular spaceGO:0056158.0ALB, F8, APOH, TNF, F2

Biological processes related to Compartment Syndrome according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.9APOH, F2
2positive regulation of blood coagulationGO:0301949.9APOH, F2
3positive regulation of protein transportGO:0512229.7TNF, LRP1
4lipoprotein metabolic processGO:0421579.6ALB, LRP1
5CDP-choline pathwayGO:0066579.6CHKA, CHKB
6blood coagulation, intrinsic pathwayGO:0075979.5F8, APOH, F2
7phosphatidylethanolamine biosynthetic processGO:0066469.5CHKA, CHKB
8acute-phase responseGO:0069539.3F8, F2
9phosphatidylcholine biosynthetic processGO:0066569.3CHKB, CHKA
10platelet activationGO:0301689.1F2, F8, ALB
11phospholipid metabolic processGO:0066448.9CHKB, CHKA, PIK3C2A

Molecular functions related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen bindingGO:0198259.7MB, ALB
2choline kinase activityGO:0041039.3CHKB, CHKA
3ethanolamine kinase activityGO:0043059.1CHKB, CHKA

Products for genes affiliated with Compartment Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Compartment Syndrome

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet