MCID: CMP008
MIFTS: 51

Compartment Syndrome malady

Summaries for Compartment Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Compartment syndrome is a life-threatening condition of the limbs which occurs after an injury, when... more...

MalaCards: Compartment Syndrome, also known as compartment syndromes, is related to hypertension and acute pancreatitis. An important gene associated with Compartment Syndrome is CHKB (choline kinase beta), and among its related pathways are Selected targets of HNF1 and Selenium Pathway. The compounds warfarin and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and testes, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Compartment Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

compartment syndrome 8 42
compartment syndromes 44 60
compartmental syndrome, nos 8


External Ids:

Disease Ontology8 DOID:682
ICD9CM27 958.90
MeSH34 D003161

Related Diseases for Compartment Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9ALB, F2
2acute pancreatitis30.5SLC17A5, MB
3pancreatitis30.5SLC17A5, ALB
4neuropathy30.2ALB, PIK3C2A, MB
5myositis30.2MB, PIK3C2A, CHKA, CHKB, SLC17A5
6malignant hyperthermia30.0PIK3C2A, MB
7hypothyroidism30.0F8, PIK3C2A, CHKA, CHKB
8ischemia30.0MB, PIK3C2A, CHKA, CHKB, SLC17A5
9pulmonary embolism30.0ALB, F2, APOH
10diabetes mellitus30.0TNF, F8, PIK3C2A, ALB
11anuria29.8MB
12hellp syndrome29.8SLC17A5, APOH
13hypokalemia29.8PIK3C2A, MB
14thrombocytosis29.8F2
15ovarian hyperstimulation syndrome29.8ALB
16intracranial hypertension29.8ALB
17hepatitis a29.8F8, F2
18lupus erythematosus29.8F2, APOH
19protein c deficiency29.8F2, APOH
20sarcoma29.8HELLS, MB, F8
21toxic shock syndrome29.8TNF
22hemorrhagic disease29.8F8, F2
23disseminated intravascular coagulation29.8MB, F8, PIK3C2A, F2
24factor viii deficiency29.8F8, F2
25leukemia29.8F8, TNF, HELLS
26hepatitis29.8F2, SLC17A5, ALB
27rheumatoid arthritis29.8CHKB, APOH, TNF, MB
28arthritis29.8ALB, TNF, MB
29vascular disease29.8MB, TNF, APOH, F8, PIK3C2A
30systemic lupus erythematosus29.8F2, F8, APOH, TNF
31peritonitis29.8MB, TNF, F2, ALB
32anterior compartment syndrome10.8
33capillary leak syndrome10.4
34abdominal aortic aneurysm10.3
35aortic aneurysm10.3
36ruptured abdominal aortic aneurysm10.3
37ruptured aortic aneurysm10.3
38pyomyositis10.2
39burns10.1
40cystadenoma10.1
41adult syndrome10.1
42megacolon10.1
43ovarian cystadenoma10.1
44arteriovenous fistula10.0
45toxic megacolon10.0
46sciatic neuropathy10.0
47mucinous ovarian cystadenoma10.0
48cerebritis10.0
49dengue hemorrhagic fever10.0
50volkmann contracture10.0

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to compartment syndrome

Clinical Features for Compartment Syndrome

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Drugs & Therapeutics for Compartment Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Compartment Syndrome

Drug clinical trials:

Search ClinicalTrials for Compartment Syndrome

Search NIH Clinical Center for Compartment Syndrome

Search CenterWatch for Compartment Syndrome

Genetic Tests for Compartment Syndrome

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Anatomical Context for Compartment Syndrome

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32MalaCards
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MalaCards organs/tissues related to Compartment Syndrome:

32
Bone, Liver, Testes, Bone marrow, Kidney, Colon, Skeletal muscle, Breast, Heart, Myeloid, B cells, Tongue, T cells, Lung, Fetal liver

Animal Models for Compartment Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Compartment Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.8F8, APOH, TNF, MB, PIK3C2A, CHKA
2MP:00053766.3ALB, HELLS, MB, TNF, APOH, F8

Publications for Compartment Syndrome

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Sources:
50PubMed
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Articles related to Compartment Syndrome:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
One elevated bladder pressure measurement may not be enough to diagnose abdominal compartment syndrome. (23336652)
2013
2
Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. (23103728)
2013
3
Intramuscular pressure before and after botulinum toxin in chronic exertional compartment syndrome of the leg: a preliminary study. (23969633)
2013
4
Compartment syndrome. (24069672)
2013
5
Pre-peritoneal pelvic packing in a paediatric unstable pelvic fracture: an undescribed complication of lower limb compartment syndrome. (22727019)
2013
6
A rare case of acute compartment syndrome after saphenectomy. (24303473)
2013
7
Compartment syndrome after gynecologic operations: evidence from case reports and reviews. (24290432)
2013
8
Risk factors for chronic exertional compartment syndrome in a physically active military population. (23911700)
2013
9
Acute compartment syndrome of the upper extremity in children: diagnosis, management, and outcomes. (24432081)
2013
10
Abdominal compartment syndrome: a rare complication of an ovarian tumour. (24127973)
2013
11
Supraspinatus and infraspinatus compartment syndrome following scapular fracture. (23858293)
2013
12
Successful early surgical treatment in neonatal compartment syndrome: case report. (23664365)
2013
13
Does regional anaesthesia in trauma patients lead to delayed recognition of compartment syndrome? (24049839)
2013
14
Compartment syndrome of the arm caused by transcatheter angiography or angioplasty. (23276344)
2013
15
Minocycline ameliorates lung and liver dysfunction in a rodent model of hemorrhagic shock/resuscitation plus abdominal compartment syndrome. (22591920)
2013
16
Changes in leg pain after bilateral fasciotomy to treat chronic compartment syndrome: a case series study. (23561303)
2013
17
Acute compartment syndrome of the thigh 10 days following an elective primary total hip replacement. (23898004)
2013
18
Pathophysiology and Management of Acute Kidney Injury in the Setting of Abdominal Compartment Syndrome. (22314211)
2012
19
Acute compartment syndrome of the thigh following total knee arthroplasty. (21420301)
2012
20
Cytomegalovirus enterocolitis presenting as abdominal compartment syndrome in a premature neonate. (21633852)
2012
21
Reconstruction of the foot after leg or foot compartment syndrome. (22548865)
2012
22
Extensive hematoma in the superficial posterior compartment with threatening compartment syndrome after ambulatory phlebectomy. (22913523)
2012
23
A popliteal artery aneurysm presenting with ab extrinseco popliteal vein occlusion and compartment syndrome: a case report. (23064307)
2012
24
The incidence of compartment syndrome after flexible nailing of pediatric tibial shaft fractures. (23205145)
2011
25
The impact of compartment syndrome on hospital length of stay and charges among adult patients admitted with a fracture of the tibia. (21577071)
2011
26
Long-term implications of intra-abdominal hypertension and abdominal compartment syndrome: physical, mental, and financial. (21944458)
2011
27
Compartment syndrome-induced microvascular dysfunction: an experimental rodent model. (21443836)
2011
28
Abdominal compartment syndrome caused by a bulimic attack in a bulimia nervosa patient. (22319729)
2011
29
Compartment syndrome of the forearm: a systematic review. (21371630)
2011
30
Painful medial knee compartment syndrome in over-45 year-olds: I--medical or surgical management: a series of 174 patients. (21543278)
2011
31
Compartment syndrome in patients with massive venous thrombosis after inferior vena cava filter placement. (21410121)
2011
32
Intra-abdominal hypertension and abdominal compartment syndrome in nontrauma surgical patients. (21944455)
2011
33
Abdominal compartment syndrome induced by massive pneumoperitoneum. (20798087)
2011
34
Acute lower limb compartment syndrome after Cesarean section: a case report. (21513525)
2011
35
Lower extremity compartment syndrome after laparoscopic radical hysterectomy: brief report of an unusual complication of laparoscopic positioning requirements. (21777846)
2011
36
Chronic exertional compartment syndrome testing: a minimalist approach. (21606173)
2011
37
A fatal case of flufenoxuron-containing insecticide poisoning complicated by lactic acidosis, shock, abdominal compartment syndrome. (22077252)
2011
38
Acute compartment syndrome of the dorsal forearm following noncontact injury. (20925169)
2010
39
Clinical practice guidelines for the management of acute limb compartment syndrome following trauma. (20575916)
2010
40
Cellulitis with compartment syndrome as a complication of varicella zoster infection. (18157764)
2008
41
Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. (18689547)
2008
42
Atraumatic compartment syndrome: a manifestation of toxic shock and infectious pyomyositis in a child. A case report. (17545439)
2007
43
Desflurane, malignant hyperthermia, and release of compartment syndrome. (15845684)
2005
44
Multifocal streptococcal pyomyositis complicated by acute compartment syndrome: case report. (11360777)
2001
45
Fasciotomy for exertional anterior compartment syndrome: is lateral compartment release necessary? (10424211)
1999
46
Anterior compartment syndrome of the leg, a clinical-anatomical perspective: a case report. (9800923)
1998
47
Myositis ossificans: calcification of the entire tibialis anterior after ischaemic injury (compartment syndrome). (8666650)
1996
48
The effects of elevated compartment pressure on tibial arteriovenous flow and relationship of mechanical and biochemical characteristics of fascia to genesis of chronic anterior compartment syndrome. (7769739)
1995
49
The anterior compartment syndrome in the lower leg. Review and role of the EMG examination. (2097862)
1990
50
Diagnosis of chronic anterior compartment syndrome in the lower leg. (3604630)
1987

Genetic Variations for Compartment Syndrome

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Expression for genes affiliated with Compartment Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for genes affiliated with Compartment Syndrome

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Sources:
12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Compartment Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ALB, F8, APOH
29.6ALB, F2, TNF

Compounds for genes affiliated with Compartment Syndrome

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Compartment Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.2PIK3C2A, APOH
2alpha tocopherol4410.0APOH, CHKA, CHKB
3kaolin4410.0APOH, F2, F8
4Coagulation Factor IX1110.0LRP1, F2, F8
5hepaplastin4410.0ALB, SLC17A5, F2
6hydroxyethyl starch449.9ALB, F2, F8
7dantrolene44 28 1111.9PIK3C2A, MB, CHKB
8alpha-hydroxybutyrate449.8SLC17A5, PIK3C2A, MB, CHKB
9succinylcholine44 28 1111.8MB, PIK3C2A, CHKB, SLC17A5
10bezafibrate44 28 1111.7MB, PIK3C2A, CHKB, SLC17A5
11uric acid44 2410.7CHKA, APOH, CHKB, PIK3C2A
12gamma-hydroxybutyrate449.6CHKB, PIK3C2A, MB
13phosphocreatine44 2410.6CHKA, PIK3C2A, CHKB, MB
14heparin44 28 11 2412.6MB, F8, APOH, PIK3C2A, CHKB
15vitamin b12449.6MB, ALB, APOH, SLC17A5
16melphalan44 1110.5PIK3C2A, CHKB, MB, TNF
17halothane44 28 1111.5MB, SLC17A5, CHKB, PIK3C2A, ALB
18endotoxin449.5TNF, APOH, F8, CHKB, SLC17A5
19cocaine44 1110.4SLC17A5, MB, APOH, PIK3C2A, CHKB
20polyethylene glycol449.4SLC17A5, F2, MB, F8, CHKB, ALB
21ivig449.4PIK3C2A, APOH, TNF, ALB, F8
22malondialdehyde449.4SLC17A5, CHKB, PIK3C2A, APOH, CHKA
23homocysteine44 2410.3APOH, F8, F2, PIK3C2A, ALB
24phosphatidylcholine449.3F2, APOH, F8, CHKA, MB
25pge1449.3APOH, F2, SLC17A5, PIK3C2A
26atorvastatin44 49 28 11 2413.2TNF, PIK3C2A, SLC17A5, CHKB, CHKA
27urea44 11 2411.2ALB, SLC17A5, CHKB, CHKA, PIK3C2A
28epinephrine44 11 2411.2F8, PIK3C2A, MB, CHKB, F2, SLC17A5
29n acetylcysteine449.2CHKB, MB, TNF, CHKA, SLC17A5, F2
30phosphorus449.1ALB, PIK3C2A, SLC17A5, CHKA, CHKB, APOH
31thyroxine44 2410.1MB, ALB, PIK3C2A, CHKA, CHKB, SLC17A5
32ascorbic acid44 2410.0MB, PIK3C2A, CHKB, SLC17A5, CHKA, ALB
33simvastatin44 49 59 28 11 2414.0F2, PIK3C2A, CHKA, TNF, CHKB, SLC17A5
34cyclosporin a44 28 5911.0F2, F8, SLC17A5, PIK3C2A, TNF, CHKB
35iron44 249.9ALB, F8, APOH, PIK3C2A, MB, SLC17A5
36polyacrylamide448.9CHKB, CHKA, SLC17A5, F8, APOH, HELLS
37citrate448.9CHKB, F8, ALB, F2, MB, CHKA
38methotrexate44 49 1110.9APOH, PIK3C2A, CHKB, F2, TNF, ALB
39superoxide44 249.7CHKA, CHKB, SLC17A5, APOH, TNF
40prednisolone44 28 1110.7ALB, APOH, TNF, MB, F8, PIK3C2A
41fatty acid448.7CHKA, PIK3C2A, CHKB, LRP1, ALB, APOH
42fibrinogen448.6PIK3C2A, APOH, F8, TNF, CHKB, ALB
43lysine448.5CHKA, CHKB, LRP1, APOH, HELLS, F8
44aspartate448.5F8, CHKB, F2, LRP1, SLC17A5, ALB
45cholesterol44 28 11 2411.5ALB, CHKB, PIK3C2A, CHKA, SLC17A5, F8
46vegf448.4TNF, LRP1, CHKB, PIK3C2A, APOH, MB
47creatinine448.4SLC17A5, F2, CHKB, CHKA, ALB, PIK3C2A
48glucose448.4ALB, LRP1, APOH, SLC17A5, CHKA, CHKB
49lactate448.1ALB, SLC17A5, F2, CHKB, MB, CHKA
50alanine448.0ALB, MB, HELLS, PIK3C2A, SLC17A5, F2

GO Terms for genes affiliated with Compartment Syndrome

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16Gene Ontology
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Biological processes related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CDP-choline pathwayGO:0066579.9CHKB, CHKA
2phosphatidylethanolamine biosynthetic processGO:0066469.9CHKB, CHKA
3negative regulation of fibrinolysisGO:0519189.8APOH, F2
4blood coagulation, intrinsic pathwayGO:0075979.8F2, F8, APOH
5positive regulation of blood coagulationGO:0301949.6F2, APOH

Molecular functions related to Compartment Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ethanolamine kinase activityGO:0043059.9CHKB, CHKA
2choline kinase activityGO:0041039.6CHKB, CHKA

Products for genes affiliated with Compartment Syndrome

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Compartment Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet