MCID: CMP008
MIFTS: 47

Compartment Syndrome malady

Rare diseases category

Aliases & Classifications for Compartment Syndrome

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Compartment Syndrome, Aliases & Descriptions:

Name: Compartment Syndrome 9 41
Compartment Syndromes 43 60
 
Compartmental Syndrome, Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:682
MeSH33 D003161
ICD9CM27 958.90

Summaries for Compartment Syndrome

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Wikipedia:63 Compartment syndrome is increased pressure within one of the body\'s compartments which contains muscles... more...

MalaCards based summary: Compartment Syndrome, also known as compartment syndromes, is related to anuria and malignant hyperthermia. An important gene associated with Compartment Syndrome is CHKB (choline kinase beta), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and FOXA2 and FOXA3 transcription factor networks. The compounds kaolin and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and testes, and related mouse phenotypes are muscle and growth/size/body.

Related Diseases for Compartment Syndrome

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Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1anuria30.7MB
2malignant hyperthermia30.6PIK3C2A, MB
3calcinosis30.6PIK3C2A
4factor viii deficiency30.5F8
5hellp syndrome30.4SLC17A5, APOH
6ectopic pregnancy30.4CHKB, PIK3C2A
7neuropathy30.4MB, ALB, PIK3C2A
8hemophilia a30.4F2, F8
9protein c deficiency30.3F2, APOH
10hypokalemia30.3MB, PIK3C2A
11myositis30.2CHKA, PIK3C2A, CHKB, MB, SLC17A5
12hypothyroidism30.2CHKB, F8, CHKA, PIK3C2A
13pulmonary embolism30.1F2, APOH, ALB
14ischemia30.0CHKB, MB, SLC17A5, CHKA, PIK3C2A
15disseminated intravascular coagulation30.0PIK3C2A, F8, MB, F2
16rheumatoid arthritis29.9APOH, TNF, MB, CHKB
17hepatitis29.9F8, F2, SLC17A5
18peritonitis29.8ALB, TNF, MB, F2
19liver disease29.7F2, TNF, ALB
20systemic lupus erythematosus29.6APOH, F8, TNF, F2
21vascular disease29.5MB, F8, APOH, TNF, PIK3C2A
22arthritis29.5ALB, MB, TNF
23anterior compartment syndrome10.8
24retinal artery occlusion10.6APOH
25sneddon syndrome10.6APOH
26factor xii deficiency10.6APOH
27central retinal vein occlusion10.6APOH
28choledocholithiasis10.5SLC17A5
29retinal vasculitis10.5APOH
30aneurysm10.5
31legionaire disease10.5PIK3C2A
32capillary leak syndrome10.5
33erysipelas10.5PIK3C2A
34fascioliasis10.5SLC17A5
35gas gangrene10.5PIK3C2A
36acute pancreatitis10.4
37pancreatitis10.4
38systemic capillary leak syndrome10.4
39status asthmaticus10.4PIK3C2A
40dysfibrinogenemia10.4F2
41dysphagia10.4PIK3C2A
42hypersplenism10.4F2
43lymphangiosarcoma10.4F8
44spinocerebellar ataxia10.4MB, CHKB
45abdominal aortic aneurysm10.4
46aortic aneurysm10.4
47pericardial effusion10.4CHKB, PIK3C2A
48cryoglobulinemia10.4SLC17A5, APOH
49myocarditis10.3MB, CHKB
50intermediate coronary syndrome10.3MB, PIK3C2A

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to compartment syndrome

Symptoms for Compartment Syndrome

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Drugs & Therapeutics for Compartment Syndrome

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Drug clinical trials:

Search ClinicalTrials for Compartment Syndrome

Search NIH Clinical Center for Compartment Syndrome

Genetic Tests for Compartment Syndrome

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Anatomical Context for Compartment Syndrome

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MalaCards organs/tissues related to Compartment Syndrome:

31
Kidney, Liver, Testes, Bone marrow, Bone, Skeletal muscle, Heart, Colon, Breast, Myeloid, Lung, Tongue

Animal Models for Compartment Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Compartment Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3LRP1, TNF, CHKB, ALB, MB
2MP:00053787.9SLC17A5, MB, TNF, LRP1, PIK3C2A, F2
3MP:00053977.5F2, PIK3C2A, LRP1, TNF, F8, MB
4MP:00107685.8TNF, LRP1, PIK3C2A, F2, APOH, CHKA
5MP:00053765.6SLC17A5, F2, PIK3C2A, LRP1, TNF, APOH

Publications for Compartment Syndrome

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Articles related to Compartment Syndrome:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Intraocular Pressure Changes in Emergent Surgical Decompression of Orbital Compartment Syndrome. (25880995)
2015
2
Predictive factors of abdominal compartment syndrome in neonatal age. (23456905)
2014
3
Postinjury abdominal compartment syndrome: from recognition to prevention. (25390328)
2014
4
Acute compartment syndrome after intramedullary nailing of isolated radius and ulna fractures in children. (23812132)
2014
5
Abdominal compartment syndrome: Incidence and prognostic factors influencing survival in Singapore. (25316974)
2014
6
Abdominal compartment syndrome in severe acute pancreatitis treated with percutaneous catheter drainage. (25325011)
2014
7
Abdominal compartment syndrome - the prevention and treatment of possible lethal complications following hip arthroscopy: a case report. (25394557)
2014
8
Chronic exertional compartment syndrome of the leg in the military. (25280617)
2014
9
Incidence and prognosis of intraabdominal hypertension and abdominal compartment syndrome in children. (25783342)
2014
10
Upper arm compartment syndrome: a case report and review of the literature. (24002844)
2013
11
Upper limb compartment syndrome: An unusual complication of stroke thrombolysis. (24291484)
2013
12
Is surgery effective for deep posterior compartment syndrome of the leg? A systematic review. (24065078)
2013
13
Chronic exertional compartment syndrome of the forearm in elite rowers: a technique for mini-open fasciotomy and a report of six cases. (24426965)
2013
14
Paravertebral compartment syndrome after training causing severe back pain in an amateur rugby player: report of a rare case and review of the literature. (24004522)
2013
15
One elevated bladder pressure measurement may not be enough to diagnose abdominal compartment syndrome. (23336652)
2013
16
Orbital compartment syndrome following extracorporeal support. (23898881)
2013
17
Management of Chronic Exertional Compartment Syndrome and Fascial Hernias in the Anterior Lower Leg With the Forefoot Rise Test and Limited Fasciotomy. (24271459)
2013
18
Compartment syndrome as a spectrum of purple glove syndrome following intravenous phenytoin administration in a young male: a case report and review of literature. (24005736)
2013
19
Compartment syndrome of the hand from prolonged immobilization secondary to drug overdose. (23340119)
2013
20
Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency. (23103728)
2013
21
Contrast enhanced ultrasound (CEUS) and time intensity curve (TIC) analysis in compartment syndrome: first results. (22538530)
2012
22
Forearm compartment syndrome owing to being stuck in the birth canal: a case report. (23164029)
2012
23
Abdominal compartment syndrome caused by tension pneumoperitoneum in a scuba diver. (23131212)
2012
24
Bilateral lower limb compartment syndrome: a potentially destructive complication of breast reduction. (22613285)
2012
25
Radiographic predictors of visual outcome in orbital compartment syndrome. (21946770)
2012
26
Acute paediatric compartment syndrome of the hand caused by hereditary angiooedema. (22004624)
2011
27
Lateral leg compartment syndrome caused by ill-fitting compression stocking placed for deep vein thrombosis prophylaxis during surgery: a case report. (21616687)
2011
28
What is the effect of compartment syndrome and fasciotomies on fracture healing in tibial fractures? (21993369)
2011
29
Abdominal compartment syndrome caused by massive pyonephrosis in an infant with primary obstructive megaureter. (21811507)
2011
30
Vascular-type Ehlers-Danlos syndrome presenting as recurrent compartment syndrome. (21982893)
2011
31
Abdominal Compartment Syndrome complicating massive hemorrhage from an unusual presentation of ruptured ectopic pregnancy. (21912014)
2011
32
Spontaneous thigh compartment syndrome. (21691491)
2011
33
Deltoid compartment syndrome is a surgical emergency. (20926313)
2010
34
Compartment syndrome as a complication of the lithotomy position. (21702244)
2010
35
Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. (20417482)
2010
36
Compartment syndrome of the foot secondary to fixation of ankle fracture--a case report. (20655005)
2010
37
Compartment syndrome after Bothrops jararaca snakebite: monitoring, treatment, and outcome. (20095815)
2010
38
Adder bite: an uncommon cause of compartment syndrome in northern hemisphere. (20854675)
2010
39
Interventional and surgical management of abdominal compartment syndrome in severe acute pancreatitis. (20571292)
2010
40
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
41
Revision surgery for exertional anterior compartment syndrome of the lower leg: technique, findings, and results. (15888718)
2005
42
Desflurane, malignant hyperthermia, and release of compartment syndrome. (15845684)
2005
43
Multifocal streptococcal pyomyositis complicated by acute compartment syndrome: case report. (11360777)
2001
44
Compartment syndrome in both lower legs after prolonged surgery in the lithotomy position]. (9627455)
1998
45
Treatment of chronic exertional anterior compartment syndrome with massage: a pilot study. (9448951)
1998
46
Anterior dissection of popliteal cyst causing anterior compartment syndrome. (7562776)
1995
47
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
48
The anterior compartment syndrome in the lower leg. Review and role of the EMG examination. (2097862)
1990
49
Diagnosis of chronic anterior compartment syndrome in the lower leg. (3604630)
1987
50
Neglected acute post exertional anterior compartment syndrome: a case report. (3842737)
1985

Variations for Compartment Syndrome

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Expression for genes affiliated with Compartment Syndrome

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Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for genes affiliated with Compartment Syndrome

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Pathways related to Compartment Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6F8, F2
29.5ALB, F2
39.5TNF, LRP1
4
Show member pathways
thioredoxin pathway36
8.9ALB, TNF, F2
5
Show member pathways
8.8PIK3C2A, CHKA, CHKB

Compounds for genes affiliated with Compartment Syndrome

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Compounds related to Compartment Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1kaolin439.5F2, F8, APOH
2alpha-hydroxybutyrate439.4CHKB, SLC17A5, MB, PIK3C2A
3hepaplastin439.4SLC17A5, ALB, F2
4succinylcholine43 49 28 1212.4SLC17A5, MB, PIK3C2A, CHKB
5bezafibrate43 28 1211.3PIK3C2A, CHKB, SLC17A5, MB
6dantrolene28 43 1211.1PIK3C2A, CHKB, MB
7vitamin b12439.0APOH, ALB, MB, SLC17A5
8hydroxyethyl starch439.0ALB, F2, F8
9cocaine43 1210.0MB, CHKB, APOH, SLC17A5, PIK3C2A
10halothane43 49 28 1211.9ALB, MB, CHKB, SLC17A5, PIK3C2A
11phosphocreatine43 249.9CHKA, PIK3C2A, CHKB, MB
12melphalan43 49 1210.9CHKB, PIK3C2A, TNF, MB
13pge1438.8APOH, PIK3C2A, F2, SLC17A5
14endotoxin438.7CHKB, F8, APOH, SLC17A5, TNF
15warfarin43 49 24 1211.6PIK3C2A, ALB, F8, F2, APOH
16homocysteine43 249.6F2, ALB, F8, APOH, PIK3C2A
17alpha tocopherol438.6APOH, CHKA, ALB, CHKB, MB
18polyethylene glycol438.6SLC17A5, MB, ALB, F8, CHKB, F2
19malondialdehyde438.5SLC17A5, APOH, CHKA, CHKB, PIK3C2A
20epinephrine43 24 1210.5CHKB, F8, SLC17A5, MB, F2, PIK3C2A
21ivig438.4PIK3C2A, ALB, F8, APOH, TNF
22polyacrylamide438.4SLC17A5, CHKB, APOH, CHKA, F8
23phosphatidylcholine438.4MB, F2, F8, CHKA, APOH
24urea43 24 1210.3PIK3C2A, CHKA, ALB, CHKB, SLC17A5
25iron43 249.3APOH, F8, ALB, PIK3C2A, SLC17A5, MB
26atorvastatin43 49 28 24 1212.2CHKB, CHKA, PIK3C2A, SLC17A5, TNF
27cyclosporin a43 28 5910.1PIK3C2A, SLC17A5, F8, CHKB, TNF, F2
28phosphorus438.1PIK3C2A, APOH, CHKA, CHKB, ALB, SLC17A5
29thyroxine43 249.1SLC17A5, MB, ALB, CHKB, CHKA, PIK3C2A
30uric acid43 249.1CHKA, APOH, SLC17A5, PIK3C2A, CHKB, ALB
31n acetylcysteine438.0CHKB, CHKA, SLC17A5, MB, TNF, F2
32ascorbic acid43 249.0CHKA, PIK3C2A, ALB, MB, SLC17A5, CHKB
33vegf437.9LRP1, F8, CHKB, APOH, TNF, PIK3C2A
34simvastatin43 49 59 28 24 1212.9TNF, PIK3C2A, F2, CHKA, CHKB, SLC17A5
35methotrexate49 43 129.9PIK3C2A, F2, SLC17A5, TNF, APOH, ALB
36superoxide43 248.8APOH, SLC17A5, CHKB, CHKA, TNF, PIK3C2A
37fatty acid437.7ALB, CHKA, APOH, LRP1, PIK3C2A, SLC17A5
38testosterone43 59 24 1210.7SLC17A5, MB, PIK3C2A, CHKB, CHKA, ALB
39citrate437.6CHKB, F8, MB, CHKA, PIK3C2A, F2
40prednisolone43 28 129.5ALB, TNF, PIK3C2A, SLC17A5, MB, F8
41oxygen43 248.5MB, SLC17A5, CHKB, CHKA, APOH, TNF
42fibrinogen437.4SLC17A5, ALB, F8, CHKB, APOH, PIK3C2A
43heparin43 28 24 1210.4MB, ALB, F8, CHKB, LRP1, PIK3C2A
44cholesterol43 28 24 1210.3F8, SLC17A5, CHKB, ALB, CHKA, APOH
45glucose437.2CHKA, CHKB, F8, ALB, PIK3C2A, LRP1
46alanine437.2PIK3C2A, SLC17A5, MB, F8, CHKB, ALB
47creatinine436.9F8, CHKB, CHKA, PIK3C2A, F2, APOH
48aspartate436.9SLC17A5, ALB, MB, LRP1, F8, CHKB
49lipid436.8ALB, F8, CHKA, APOH, PIK3C2A, TNF
50lactate436.3F2, CHKA, CHKB, F8, ALB, MB

GO Terms for genes affiliated with Compartment Syndrome

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Cellular components related to Compartment Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5ALB, F8
2clathrin-coated vesicleGO:00301369.3LRP1, PIK3C2A
3extracellular spaceGO:00056158.0ALB, F8, APOH, TNF, F2

Biological processes related to Compartment Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:00519189.9APOH, F2
2positive regulation of blood coagulationGO:00301949.9APOH, F2
3positive regulation of protein transportGO:00512229.7TNF, LRP1
4lipoprotein metabolic processGO:00421579.6ALB, LRP1
5CDP-choline pathwayGO:00066579.6CHKA, CHKB
6blood coagulation, intrinsic pathwayGO:00075979.5F8, APOH, F2
7phosphatidylethanolamine biosynthetic processGO:00066469.5CHKA, CHKB
8acute-phase responseGO:00069539.3F8, F2
9phosphatidylcholine biosynthetic processGO:00066569.3CHKB, CHKA
10platelet activationGO:00301689.1F2, F8, ALB
11phospholipid metabolic processGO:00066448.9CHKB, CHKA, PIK3C2A

Molecular functions related to Compartment Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxygen bindingGO:00198259.7MB, ALB
2choline kinase activityGO:00041039.3CHKB, CHKA
3ethanolamine kinase activityGO:00043059.1CHKB, CHKA

Products for genes affiliated with Compartment Syndrome

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Sources for Compartment Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet