CAIS
MCID: CMP034
MIFTS: 27

Complete Androgen Insensitivity Syndrome (CAIS) malady

Summaries for Complete Androgen Insensitivity Syndrome

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MalaCards: Complete Androgen Insensitivity Syndrome, also known as androgen insensitivity syndrome, complete, is related to androgen insensitivity syndrome and sertoli cell tumor. An important gene associated with Complete Androgen Insensitivity Syndrome is AR (androgen receptor), and among its related pathways are Nuclear Receptor transcription pathway and Ovarian steroidogenesis. The compounds vitamin a and Cyproterone have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Aliases & Classifications for Complete Androgen Insensitivity Syndrome

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42NIH Rare Diseases, 20GeneTests, 44Novoseek
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Aliases & Descriptions:

complete androgen insensitivity syndrome 42
androgen insensitivity syndrome, complete 42 20
androgen insensitivity syndrome complete 44
cais 42


Related Diseases for Complete Androgen Insensitivity Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Complete Androgen Insensitivity Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1androgen insensitivity syndrome31.9CGA, LYVE1, AR
2sertoli cell tumor30.8AR, CYP19A1
3leydig cell tumor30.8CYP19A1, CGA
4adenoma30.6CGA
5leukemia29.9NR1H2, ALPPL2
6sertoli-leydig cell tumor10.5
7adult syndrome10.4
8amenorrhea10.2
9n syndrome10.2
10breast fibroadenoma10.2
11gonadal dysgenesis10.2
12leiomyoma10.2
13prostatitis10.2
14seminoma10.2
15sexual disorder10.2
16vaginitis10.2
17image syndrome10.2
18sarcoma10.0AR
19diabetes mellitus10.0ALPPL2
20male infertility10.0AR
21fibrous dysplasia10.0ALPPL2
22cholelithiasis10.0ALPPL2
23prostatic hypertrophy10.0AR
24ovarian disease10.0CYP19A1
25adenocarcinoma10.0AR
26insulin resistance10.0NR1H2
27osteomalacia10.0ALPPL2
28x-linked spinal-bulbar muscle atrophy10.0LYVE1, AR
29melanoma10.0NR1H2
30colorectal cancer10.0LYVE1, ALPPL2
31endocrine gland cancer10.0CYP19A1, AR
32androgenic alopecia10.0AR, CYP19A1
33prostate disease10.0AR, CYP19A1
34germinoma10.0CGA
35dysgerminoma10.0CGA
36thyroiditis10.0CGA
37atherosclerosis10.0NR1H2, LYVE1
38pseudohermaphroditism10.0CYP19A1, AR
39hypopituitarism10.0CGA
40penis agenesis10.0CGA, AR
41conduct disorder10.0CGA
42partial androgen insensitivity syndrome10.0LYVE1, CYP19A1, AR
43oligospermia10.0AR, CGA
44testicular cancer10.0CGA, ALPPL2
45adrenal adenoma10.0CYP19A1, NR1H2
46vascular disease10.0PTGDS, ALPPL2
47endometriosis10.0CYP19A1, CGA
48ovarian cyst10.0CGA, CYP19A1
49aorta atresia10.0CGA, CYP19A1
50anovulation10.0CGA, CYP19A1

Graphical network of the top 20 diseases related to Complete Androgen Insensitivity Syndrome:



Diseases related to complete androgen insensitivity syndrome

Clinical Features for Complete Androgen Insensitivity Syndrome

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Drugs & Therapeutics for Complete Androgen Insensitivity Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Complete Androgen Insensitivity Syndrome

Drug clinical trials:

Search ClinicalTrials for Complete Androgen Insensitivity Syndrome

Search NIH Clinical Center for Complete Androgen Insensitivity Syndrome

Search CenterWatch for Complete Androgen Insensitivity Syndrome

Genetic Tests for Complete Androgen Insensitivity Syndrome

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20GeneTests
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Genetic tests related to Complete Androgen Insensitivity Syndrome:

id Genetic test Affiliating Genes
1 Complete Androgen Insensitivity Syndrome20

Anatomical Context for Complete Androgen Insensitivity Syndrome

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Animal Models for Complete Androgen Insensitivity Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Complete Androgen Insensitivity Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.8LYVE1, PTGDS, CYP19A1, NR1H2, AR

Publications for Complete Androgen Insensitivity Syndrome

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Genetic Variations for Complete Androgen Insensitivity Syndrome

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Expression for genes affiliated with Complete Androgen Insensitivity Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complete Androgen Insensitivity Syndrome

Search GEO for disease gene expression data for Complete Androgen Insensitivity Syndrome.

Pathways for genes affiliated with Complete Androgen Insensitivity Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Complete Androgen Insensitivity Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6NR1H2, AR
29.3CYP19A1, CGA
39.3CYP19A1, CGA
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.0CYP19A1, CGA, AR

Compounds for genes affiliated with Complete Androgen Insensitivity Syndrome

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Complete Androgen Insensitivity Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.4NR1H2
2Cyproterone119.9AR, CYP19A1
3Nandrolone phenpropionate119.9AR, CYP19A1
4Drostanolone119.8AR, CYP19A1
5vinclozolin449.8AR, CYP19A1
6dutasteride44 1110.7CYP19A1, AR
7aroclor 1254449.7CYP19A1, AR
8Methyltestosterone119.7AR, CYP19A1
9linuron449.7AR, LYVE1
10lg 100268449.7NR1H2, CYP19A1
11procymidone449.7AR, LYVE1
12androstenediol449.7AR, CYP19A1
13polyglycine449.6AR, LYVE1
14nandrolone decanoate44 1110.6CYP19A1, AR
15mibolerone44 2810.6AR, LYVE1
16r1881449.5AR, LYVE1
17nafarelin44 59 28 1112.5CGA, CYP19A1
18nandrolone44 2410.5CYP19A1, AR
19bisphenol a449.4CYP19A1, NR1H2, AR
20ttnpb44 28 1111.4CYP19A1, NR1H2
21ketoconazole44 28 11 2412.4AR, NR1H2, CYP19A1
22letrozole44 49 59 1112.4CYP19A1, CGA, AR
23progestins449.4AR, NR1H2, CYP19A1
24diethylstilbestrol44 28 1111.3AR, CGA, CYP19A1
253beta-hydroxysteroid449.3CYP19A1, CGA, AR
2617beta-hydroxysteroid449.3AR, CGA, CYP19A1
27dehydroepiandrosterone sulfate449.3AR, CGA, CYP19A1
28estradiol benzoate449.2CYP19A1, CGA
29metformin44 49 1111.2CYP19A1, NR1H2, CGA
30hydroxyflutamide44 2810.2AR, CGA, LYVE1
31estrone44 28 11 2412.2CYP19A1, NR1H2, AR
32troglitazone44 28 59 1112.1AR, NR1H2, CYP19A1
33progestin448.9CYP19A1, NR1H2, CGA, AR
34mifepristone44 59 28 1111.9AR, CGA, NR1H2, CYP19A1
35gnrh448.9AR, CGA, NR1H2, CYP19A1
36tamoxifen44 49 28 1111.8AR, CGA, NR1H2, CYP19A1
37vitamin d448.8AR, CGA, NR1H2, CYP19A1
38cyproteroneacetate448.7AR, NR1H2, CYP19A1, LYVE1
39bicalutamide44 59 1110.6AR, NR1H2, CYP19A1, LYVE1
40steroidal448.6AR, NR1H2, CYP19A1, LYVE1
41androstenedione44 249.6AR, CGA, CYP19A1, LYVE1
42paraffin448.5LYVE1, ALPPL2, CGA, AR
43cycloheximide448.2AR, CGA, CYP19A1, PTGDS
44flutamide44 59 1110.1LYVE1, CYP19A1, NR1H2, CGA, AR
45dihydrotestosterone44 28 11 2411.1AR, CGA, NR1H2, CYP19A1, LYVE1
46estradiol44 11 2410.1LYVE1, CYP19A1, NR1H2, CGA, AR
47progesterone44 59 28 11 2412.1AR, CGA, NR1H2, CYP19A1, LYVE1
48steroid448.1AR, CGA, NR1H2, CYP19A1, LYVE1
49arginine448.0AR, CGA, NR1H2, CYP19A1, LYVE1
50testosterone44 59 11 2410.7AR, CGA, NR1H2, CYP19A1, PTGDS, LYVE1

GO Terms for genes affiliated with Complete Androgen Insensitivity Syndrome

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16Gene Ontology
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Biological processes related to Complete Androgen Insensitivity Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostate gland growthGO:0607369.2CYP19A1, AR
2transportGO:0068108.9LYVE1, PTGDS, AR

Molecular functions related to Complete Androgen Insensitivity Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.6NR1H2, AR

Products for genes affiliated with Complete Androgen Insensitivity Syndrome

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Sources for Complete Androgen Insensitivity Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet