MCID: CMP006
MIFTS: 30

Complex Partial Epilepsy malady

Categories: Neuronal diseases

Aliases & Classifications for Complex Partial Epilepsy

Aliases & Descriptions for Complex Partial Epilepsy:

Name: Complex Partial Epilepsy 12 14
Epilepsy, Complex Partial 42 69
Complex Partial Epileptic Seizure 12
Epilepsy, Psychomotor 12
Psychomotor Epilepsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12382
MeSH 42 D017029
UMLS 69 C0085417

Summaries for Complex Partial Epilepsy

MalaCards based summary : Complex Partial Epilepsy, also known as epilepsy, complex partial, is related to alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality and alopecia, epilepsy, pyorrhea, mental subnormality, and has symptoms including seizures and seizures, focal. An important gene associated with Complex Partial Epilepsy is SLC4A10 (Solute Carrier Family 4 Member 10). The drugs Pregabalin and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, testes and brain, and related phenotype is mortality/aging.

Related Diseases for Complex Partial Epilepsy

Diseases related to Complex Partial Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality 11.9
2 alopecia, epilepsy, pyorrhea, mental subnormality 10.9
3 schindler disease, type i 10.7
4 epilepsy 10.5
5 tetanus 9.6
6 reading disorder 9.6
7 pharyngitis 9.6
8 cerebritis 9.6
9 herpes simplex 9.6
10 encephalitis 9.6
11 herpes simplex encephalitis 9.6
12 head injury 9.6
13 balantidiasis 9.1 ADSL OPRM1 ROGDI SDHA SLC4A10 SMUG1

Graphical network of the top 20 diseases related to Complex Partial Epilepsy:



Diseases related to Complex Partial Epilepsy

Symptoms & Phenotypes for Complex Partial Epilepsy

UMLS symptoms related to Complex Partial Epilepsy:


seizures, seizures, focal

MGI Mouse Phenotypes related to Complex Partial Epilepsy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.02 ADSL OPRM1 SDHA SLC4A10 SMUG1

Drugs & Therapeutics for Complex Partial Epilepsy

Drugs for Complex Partial Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Vigabatrin Approved Phase 4 68506-86-5, 60643-86-9 5665
4 Analgesics Phase 4,Phase 3
5 Anti-Anxiety Agents Phase 4,Phase 3
6 Anticonvulsants Phase 4,Phase 3,Phase 2
7 calcium channel blockers Phase 4,Phase 3
8 Calcium, Dietary Phase 4,Phase 3
9 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
10 Peripheral Nervous System Agents Phase 4,Phase 3
11 Psychotropic Drugs Phase 4,Phase 3
12 Tranquilizing Agents Phase 4,Phase 3
13 Antimanic Agents Phase 4
14 Antiparkinson Agents Phase 4
15 Excitatory Amino Acid Antagonists Phase 4,Phase 3
16 Excitatory Amino Acids Phase 4,Phase 3
17 GABA Agents Phase 4,Phase 3
18
gamma-Aminobutyric Acid Phase 4 56-12-2 119
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
20
Zonisamide Approved, Investigational Phase 3 68291-97-4 5734
21
Diazepam Approved, Illicit, Vet_approved Phase 3 439-14-5 3016
22
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
23 Piracetam Approved Phase 3 7491-74-9
24
Eslicarbazepine acetate Approved Phase 3,Phase 2 75970-99-9, 236395-14-5 123618
25
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
26
Phenytoin Approved, Vet_approved Phase 3 57-41-0 1775
27
Topiramate Approved Phase 3 97240-79-4 5284627
28
Ezogabine Approved Phase 3 150812-12-7 121892
29
Everolimus Approved Phase 3 159351-69-6 6442177
30
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
31
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
32 Antioxidants Phase 3
33 Protective Agents Phase 3,Phase 2,Phase 1
34 Adjuvants, Anesthesia Phase 3
35 Anesthetics Phase 3,Phase 2
36 Anesthetics, General Phase 3
37 Anesthetics, Intravenous Phase 3
38 Antiemetics Phase 3
39 Autonomic Agents Phase 3
40 GABA Modulators Phase 3
41 Gastrointestinal Agents Phase 3
42 Hypnotics and Sedatives Phase 3
43 Neuromuscular Agents Phase 3
44 Pharmaceutical Solutions Phase 3
45 Diuretics, Potassium Sparing Phase 3,Phase 2
46 Sodium Channel Blockers Phase 3,Phase 2
47 Etiracetam Phase 3
48 Neuroprotective Agents Phase 3,Phase 1
49 Nootropic Agents Phase 3
50 Hormone Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 55)
id Name Status NCT ID Phase
1 Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin Completed NCT01128712 Phase 4
2 Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures Completed NCT00537940 Phase 4
3 A Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®) Completed NCT01278173 Phase 4
4 Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients Terminated NCT01266291 Phase 4
5 Dose Response Study of Zonegran in Patients With Newly Diagnosed Epilepsy Completed NCT00056576 Phase 3
6 Pregabalin Open-Label Extension Trial in Patients With Partial Seizures Completed NCT00143143 Phase 3
7 An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures. Completed NCT00991757 Phase 3
8 A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures. Completed NCT00740623 Phase 3
9 An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures Completed NCT00744731 Phase 3
10 A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. Completed NCT00433667 Phase 3
11 A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. Completed NCT00425282 Phase 3
12 Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures. Completed NCT00319501 Phase 3
13 A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures Completed NCT00292461 Phase 3
14 Pregabalin Versus Levetiracetam In Partial Seizures Completed NCT00537238 Phase 3
15 Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs Completed NCT00866775 Phase 3
16 Early Surgical Intervention to Treat Epilepsy Completed NCT00040326 Phase 3
17 Remegal Fixed Dose as Adjunctive Therapy in Patients With Partial Seizures Completed NCT01749046 Phase 3
18 Evaluating the Efficacy and Safety of Zonisamide in the Treatment of Partial Seizures Completed NCT00327717 Phase 3
19 Progesterone vs Placebo Therapy for Women With Epilepsy Completed NCT00029536 Phase 3
20 A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment Completed NCT00210782 Phase 3
21 Retigabine Efficacy and Safety Trial for Partial Onset Refractory Seizures in Epilepsy Completed NCT00235755 Phase 3
22 Retigabine (Adjunctive Therapy) Efficacy and Safety Study for Partial Onset Refractory Seizures in Epilepsy Completed NCT00232596 Phase 3
23 A Long Term Follow up Administration Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures Completed NCT00367432 Phase 3
24 Open-label Extension Study of the Phase 3 VRX-RET-E22-301 Double-Blind Trial Completed NCT00310375 Phase 3
25 Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension Completed NCT01963208 Phase 3
26 Evaluating the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures Completed NCT00699972 Phase 3
27 To Evaluate The Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures Completed NCT00699582 Phase 3
28 Evaluating Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures Completed NCT00700310 Phase 3
29 Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00790400 Phase 3
30 Open-Label Extension Study of the Phase 3 VRX-RET-E22-302 Double-Blind Trial. 115097 Active, not recruiting NCT00310388 Phase 3
31 A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures Active, not recruiting NCT01713946 Phase 3
32 A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy Terminated NCT00717431 Phase 3
33 Effectiveness and Safety Study for RWJ-333369 as Adjunctive Therapy in Korean and Japanese Patients With Partial Onset Seizures Terminated NCT00697762 Phase 3
34 A Two-year Open-label Extension Study of Ganaxolone in Patients With Drug-resistant Partial-onset Seizures Terminated NCT02519439 Phase 3
35 Clobazam as Adjunctive Therapy in Paediatric Patients Aged ≥1 to ≤16 Years With Dravet Syndrome Withdrawn NCT02174094 Phase 3
36 A Treatment Use Protocol for Subjects Continuing on From the Open-label Extension 0601 Completed NCT01002820 Phase 2
37 A Placebo-controlled Study to Investigate Safety and Efficacy of BIA 2-093 Completed NCT02170077 Phase 2
38 A Randomized, Controlled Trial of Ganaxolone in Adult Uncontrolled Partial-Onset Seizures Completed NCT00465517 Phase 2
39 A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures Active, not recruiting NCT01866111 Phase 2
40 Phase 2 Study of Triheptanoin (UX007) for the Treatment of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS) Active, not recruiting NCT01993186 Phase 2
41 Bioavailability, Safety, and Tolerability of BIS-001 ER Recruiting NCT03156439 Phase 1
42 Structural and Functional Connectivity in Partial Epilepsies Studied With MRI and MEG Unknown status NCT01313260
43 Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits Unknown status NCT00851331
44 Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism Completed NCT00001489
45 Sabril Patient Registry Completed NCT01073579
46 Role of Hormones in Susceptibility to Seizures in Women With Epilepsy Completed NCT00044252
47 MRI in Autosomal Dominant Partial Epilepsy With Auditory Features Completed NCT00072813
48 Co-operative Behavior and Decision-making in Frontal Lobe Epilepsy Completed NCT02441478
49 Transcutaneous Non-invasive Stimulation of the Vagus Nerve for the Treatment of Difficult-to-treat Epilepsy Completed NCT01178437
50 Surgery as a Treatment for Medically Intractable Epilepsy Recruiting NCT01273129

Search NIH Clinical Center for Complex Partial Epilepsy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: epilepsy, complex partial

Genetic Tests for Complex Partial Epilepsy

Anatomical Context for Complex Partial Epilepsy

MalaCards organs/tissues related to Complex Partial Epilepsy:

39
Temporal Lobe, Testes, Brain, Cortex

Publications for Complex Partial Epilepsy

Articles related to Complex Partial Epilepsy:

(show top 50) (show all 55)
id Title Authors Year
1
Complex Partial Epilepsy Associated with Temporal Lobe Developmental Venous Anomaly. ( 26060525 )
2015
2
Emergence of complex partial epilepsy-like experiences following closed head injuries: personality variables and neuropsychological profiles. ( 22206825 )
2012
3
Features of a subset of children with complex partial epilepsy requiring combination therapy for effective seizure control. ( 19494358 )
2010
4
Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy. ( 19470965 )
2009
5
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. ( 18509280 )
2008
6
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. ( 18413482 )
2008
7
Re: Atypical language in lesional and nonlesional complex partial epilepsy. ( 18519879 )
2008
8
Atypical language in lesional and nonlesional complex partial epilepsy. ( 17967992 )
2007
9
Effect of vagal nerve stimulation in a case of Tourette's syndrome and complex partial epilepsy. ( 16703589 )
2006
10
Early antiepileptic drug reduction following anterior temporal lobectomy for medically intractable complex partial epilepsy. ( 15276148 )
2004
11
Intelligence functions disorders in patients with complex partial epilepsy. ( 15608956 )
2004
12
Pharyngeal dysesthesia in refractory complex partial epilepsy: new seizure or adverse effect of vagal nerve stimulation? ( 12790902 )
2003
13
Attentional disorders in patients with complex partial epilepsy. ( 12894263 )
2003
14
A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy. ( 11906955 )
2002
15
Alfentanil-induced epileptiform activity: a simultaneous surface and depth electroencephalographic study in complex partial epilepsy. ( 11240593 )
2001
16
Synchronized feeding as a "conditioned stimulus" for overt seizures in chronically (limbic) epileptic rats: a model for "psychogenic seizures" with complex partial epilepsy. ( 11264918 )
2001
17
A neurobehavioral approach for treatment of complex partial epilepsy: efficacy. ( 10775516 )
2000
18
Experience of a 3-D, Large-Field-Of-View (LFOV) PET Scanner for the Localization Of Complex Partial Epilepsy. ( 14516625 )
1999
19
Disturbances of amino acids from temporal lobe synaptosomes in human complex partial epilepsy. ( 10555778 )
1999
20
Formal thought disorder and psychopathology in pediatric primary generalized and complex partial epilepsy. ( 9291731 )
1997
21
Sex differences in cerebral language dominance in complex-partial epilepsy. ( 9112241 )
1997
22
Cost-effectiveness of anterotemporal lobectomy in medically intractable complex partial epilepsy. ( 9048666 )
1997
23
Tourette syndrome and complex partial epilepsy--a case report. ( 8753147 )
1996
24
Efficacy of the Continuous Visual Memory Test in lateralizing temporal lobe dysfunction in chronic complex-partial epilepsy. ( 8941859 )
1996
25
Combined study of 99mTc-HMPAO SPECT and computerized electroencephalographic topography (CET) in patients with medically refractory complex partial epilepsy. ( 8814713 )
1996
26
Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with complex partial epilepsy. ( 7477979 )
1995
27
MFT in complex partial epilepsy: spatio-temporal estimates of interictal activity. ( 8742407 )
1995
28
S.P.E.C.T., E.E.G. and M.R.I. investigations in complex partial epilepsy. ( 7709796 )
1994
29
Catatonia associated with depression secondary to complex partial epilepsy. ( 8444828 )
1993
30
Language and memory in children with combined complex-partial epilepsy and reading disorder. ( 8323126 )
1993
31
Herpes simplex encephalitis in a patient with complex partial epilepsy: confirmation by the polymerase chain reaction with necropsy studies. ( 8350121 )
1993
32
Visual half-field testing of memory functions in patients considered for surgical treatment of intractable complex partial epilepsy. ( 1481638 )
1992
33
Memory effects following carbamazepine monotherapy in patients with complex partial epilepsy. ( 1344773 )
1992
34
Fentanyl-induced electrocorticographic seizures in patients with complex partial epilepsy. ( 1625007 )
1992
35
Auditory/verbal and visual/spatial memory in children with complex partial epilepsy of temporal lobe origin. ( 1449761 )
1992
36
EEG dipole modeling in complex partial epilepsy. ( 1793685 )
1991
37
Excitotoxic amino acid receptors in human complex partial epilepsy. ( 1964242 )
1990
38
The critical evaluation of the late results after temporal lobectomy performed because of medically refractory complex partial epilepsy (CPE). ( 2087894 )
1990
39
Complex partial epilepsy: the role of neuroimaging in localizing a seizure focus for surgical intervention. ( 2230998 )
1990
40
Spike voltage topography and equivalent dipole localization in complex partial epilepsy. ( 2094309 )
1990
41
Detection of epileptiform activity by different noninvasive EEG methods in complex partial epilepsy. ( 2327741 )
1990
42
Barbiturate effects on EEG abnormality in complex partial epilepsy. ( 2915222 )
1989
43
Temporal intermittent rhythmic delta activity (TIRDA) in the diagnosis of complex partial epilepsy: sensitivity, specificity and predictive value. ( 2804800 )
1989
44
Effect of gamma-vinyl GABA treatment on cholinergic and aminergic neurotransmission and on cyclic nucleotides in human complex partial epilepsy--a CSF study. ( 2452456 )
1988
45
The magnetic field of epileptic spikes agrees with intracranial localizations in complex partial epilepsy. ( 3362376 )
1988
46
Somatostatin-like immunoreactivity in cerebrospinal fluid of patients with complex partial epilepsy. ( 3366146 )
1988
47
Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy. ( 3143561 )
1988
48
Somatostatin, beta-endorphin, and prolactin levels in human cerebrospinal fluid during the gamma-vinyl-GABA treatment of patients with complex partial epilepsy. ( 2885776 )
1987
49
Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations. ( 3683877 )
1987
50
Double-blind dose reduction study of vigabatrin in complex partial epilepsy. ( 3319536 )
1987

Variations for Complex Partial Epilepsy

Expression for Complex Partial Epilepsy

Search GEO for disease gene expression data for Complex Partial Epilepsy.

Pathways for Complex Partial Epilepsy

GO Terms for Complex Partial Epilepsy

Sources for Complex Partial Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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