CRPS
MCID: CMP010
MIFTS: 63

Complex Regional Pain Syndrome (CRPS) malady

Rare diseases, Neuronal diseases categories

Summaries for Complex Regional Pain Syndrome

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Sources:
44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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NINDS:45 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to migraine and obesity. An important gene associated with Complex Regional Pain Syndrome is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Pertussis. The compounds rantes and meclofenamate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and spinal cord, and related mouse phenotypes are renal/urinary system and tumorigenesis.

NIH Rare Diseases:44 Complex regional pain syndrome is a chronic pain condition that mainly affects the arms or legs and is often triggered by injury. it is characterized by constant pain, sensitivity, and skin color and temperature changes at the site of an injury. the pain is out of proportion to the severity of the injury and worsens with time. treatment aims to control these painful symptoms. last updated: 10/19/2011

MedlinePlus:35 Complex regional pain syndrome (crps) is a chronic pain condition. it causes intense pain, usually in the arms, hands, legs, or feet. it may happen after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. symptoms in the affected area are dramatic changes in skin temperature, color, or texture intense burning pain extreme skin sensitivity swelling and stiffness in affected joints decreased ability to move the affected body part the cause of crps is unknown. there is no specific diagnostic test. your doctor will diagnose crps based on your signs and symptoms. there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. nih: national institute of neurological disorders and stroke

Wikipedia:66 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Description from OMIM:48 604335

Aliases & Classifications for Complex Regional Pain Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 46Novoseek, 50Orphanet, 48OMIM, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
complex regional pain syndrome:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

complex regional pain syndrome 9 44 45 11 50 48 35
complex regional pain syndromes 9 46 63
reflex sympathetic dystrophy 11 46 63
reflex sympathetic dystrophy syndrome 44 45
crps 44


External Ids:

Disease Ontology9 DOID:3223
MeSH36 D020918
MESH via Orphanet37 D020918
ICD10 via Orphanet27 G56.4, M89.0
SNOMED-CT59 128200000
SNOMED-CT via Orphanet60 128200000
UMLS via Orphanet64 C0458219
OMIM48 604335

Related Diseases for Complex Regional Pain Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Complex Regional Pain Syndrome family:

Complex Regional Pain Syndrome Type 1

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 373)
idRelated DiseaseScoreTop Affiliating Genes
1migraine30.6HCRT, CALCA
2obesity30.5HCRT, TNF, IL6
3sepsis30.5TNF, IL6, CALCA
4atherosclerosis30.5IL6, CXCR3, TNF, EDN1
5insulin resistance30.4EDN1, TNF, IL6
6systemic lupus erythematosus30.4TNF, CXCR3, IL6
7pneumonia30.4TNF, IL6
8crohn's disease30.4TNF
9periodontitis30.3TNF, IL6
10psoriasis30.3TNF, CXCR3, IL6
11rheumatoid arthritis30.3IL6, CXCR3, TNF
12chorioamnionitis30.3IL6, TNF
13arthritis30.3IL6, TNF
14periodontal disease30.2IL6, TNF
15hepatitis c30.2TNF, CXCR3
16peritonitis30.1TNF, IL6
17ulcerative colitis30.1TNF, CXCR3, IL6
18diabetes mellitus30.0EDN1, TNF, IL6, CALCA
19osteoarthritis29.9TNF, CXCR3, IL6, CALCA
20arteriosclerosis29.9EDN1
21malaria29.8TNF
22uveitis29.8CXCR3, TNF
23juvenile rheumatoid arthritis29.8TNF, IL6
24synovitis29.7IL6, TNF
25asthma29.7EDN1, TNF, CXCR3
26paine syndrome11.5
27complex regional pain syndrome type 111.1
28reflex sympathetic dystrophy11.0
29dystonia10.8
30causalgia10.7
31blindness10.5
32osteogenesis imperfecta10.5
33cerebritis10.5
34burns10.4
35fibromyalgia10.4
36myofascial pain syndrome10.4
37pancoast tumor10.4
38dysautonomia10.4
39acute myocardial infarction10.3
40hypertension10.3
41artery disease10.3
42myocardial infarction10.3
43thoracic outlet syndrome10.3
44cervicitis10.3
45influenza10.3
46leprosy10.3
47neuropathy10.3
48somatoform disorder10.3
49tetanus10.3
50small fiber neuropathy10.3

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to complex regional pain syndrome

Symptoms for Complex Regional Pain Syndrome

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48OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Complex Regional Pain Syndrome

Drug clinical trials:

Search ClinicalTrials for Complex Regional Pain Syndrome

Search NIH Clinical Center for Complex Regional Pain Syndrome

Search CenterWatch for Complex Regional Pain Syndrome

Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

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34MalaCards
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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

34
Skin, Testes, Spinal cord, Bone, Cortex, Brain, Monocytes, Cingulate cortex, Thalamus, Heart, Eye, Endothelial, Lung, Skeletal muscle, Pituitary

Animal Models for Complex Regional Pain Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6EDN1, CXCR3, IL6, CALCA
2MP:00020068.6CALCA, IL6, CXCR3, TNF
3MP:00053908.5CALCA, IL6, TNF, EDN1
4MP:00053887.9HCRT, TNF, CXCR3, IL6, CALCA
5MP:00053697.7EDN1, HCRT, TNF, SGCE, IL6
6MP:00053767.3EDN1, HCRT, TNF, CXCR3, IL6, CALCA
7MP:00053867.3HCRT, TNF, SGCE, IL6, CALCA
8MP:00036317.3EDN1, HCRT, TNF, SGCE, IL6, CALCA
9MP:00053856.9CALCA, IL6, CXCR3, SGCE, TNF, HCRT

Publications for Complex Regional Pain Syndrome

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Sources:
53PubMed
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Articles related to Complex Regional Pain Syndrome:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Complex regional pain syndrome type I following tetanus toxoid injection. (24356477)
2014
2
Immunoglobulin maintenance therapy in long-standing complex regional pain syndrome, an open study. (24023248)
2013
3
Concurrence of malignant peripheral nerve sheath tumor at the site of complex regional pain syndrome type 1 - a case report -. (23614078)
2013
4
Complex regional pain syndrome type I following discTRODE radiofrequency treated with continuous lumbar sympathetic trunk block using patient-controlled analgesia. (23294559)
2013
5
Relationships Between Psychological Factors, Pain and Disability in Complex Regional Pain Syndrome and Low Back Pain. (24135903)
2013
6
Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. (23267031)
2013
7
Complex regional pain syndrome following trigeminal nerve injury: report of 2 cases. (23643322)
2013
8
Type II complex regional pain syndrome of the hand resulting from repeated arterial punctures during transradial coronary intervention. (23378264)
2013
9
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system. (23291454)
2013
10
A case of recurrent complex regional pain syndrome accompanying Raynaud's disease: a prospective coincidence? (23720085)
2013
11
Health-related quality of life in 975 patients with complex regional pain syndrome type 1. (24342465)
2013
12
Primary motor cortex function in complex regional pain syndrome: a systematic review and meta-analysis. (24035350)
2013
13
Is there a correlation between symptoms and bone scintigraphic findings in patients with complex regional pain syndrome? (22797817)
2012
14
Transitioning from a hospital rehabilitation programme to home: exploring the experiences of people with complex regional pain syndrome. (22260304)
2012
15
Effect of immunomodulating medications in complex regional pain syndrome: a systematic review. (22001668)
2012
16
Concordance of qualitative bone scintigraphy results with presence of clinical complex regional pain syndrome 1: meta-analysis of test accuracy studies. (22473897)
2012
17
Still's Disease and Recurrent Complex Regional Pain Syndrome Type-I: The First Description. (22162802)
2012
18
Successful reversal of complex regional pain syndrome type 1 of both upper extremities in five patients. (22776058)
2012
19
Concurrent peripheral pathologies and complex regional pain syndrome type 1 as contributors to acute post-stroke shoulder pain: a case report. (22592581)
2012
20
Complex regional pain syndrome. (21600455)
2011
21
MicroRNA modulation in complex regional pain syndrome. (22074333)
2011
22
Emotional and neuropsychological profiles of children with complex regional pain syndrome type-I in an inpatient rehabilitation setting. (20842016)
2011
23
Dexmedetomidine for the treatment of acute pain from complex regional pain syndrome. (22220237)
2011
24
Evidence based guidelines for complex regional pain syndrome type 1. (20356382)
2010
25
Migraine may be a risk factor for the development of complex regional pain syndrome. (19614690)
2010
26
Modifying diagnostic criteria for Complex Regional Pain Syndrome. (20483538)
2010
27
Plasticity of complex regional pain syndrome (CRPS) in children. (20704670)
2010
28
Botulinum toxin A (Botox) for treatment of proximal myofascial pain in complex regional pain syndrome: two cases. (20735753)
2010
29
Risk factors for complex regional pain syndrome in patients with traumatic extremity injury. (20517769)
2010
30
Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I). (20675053)
2010
31
Motor cortex dysfunction in complex regional pain syndrome. (20185362)
2010
32
Anti-inflammatory treatment of Complex Regional Pain Syndrome. (20692766)
2010
33
Complex regional pain syndrome in the adolescent athlete. (19904065)
2009
34
Mirror therapy for chronic complex regional pain syndrome type 1 and stroke. (19657134)
2009
35
Effect of vitamin C on prevention of complex regional pain syndrome type I in foot and ankle surgery. (19840748)
2009
36
Complex regional pain syndrome type 1 may be associated with menstrual cycle disorders: a case-control study. (19942105)
2009
37
Rare case of autonomic instability of the lower limb presenting as painless Complex Regional Pain Syndrome type I following hip surgery: two case reports. (19830162)
2009
38
Can the outcome of spinal cord stimulation in chronic complex regional pain syndrome type I patients be predicted by catastrophizing thoughts? (19608836)
2009
39
Does prolonged skin temperature measurement improve the diagnosis of complex regional pain syndrome? (19129786)
2009
40
fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. (18567621)
2008
41
Psychological features of patients with complex regional pain syndrome type I related dystonia. (18546322)
2008
42
Tumor necrosis factor-alpha and interleukin-6 are not correlated with the characteristics of Complex Regional Pain Syndrome type 1 in 66 patients. (18055234)
2008
43
Using skin surface temperature to differentiate between complex regional pain syndrome type 1 patients after a fracture and control patients with various complaints after a fracture. (18165590)
2008
44
Correlation between changes in regional cerebral blood flow and pain relief in complex regional pain syndrome type 1. (16714887)
2006
45
Stress infrared telethermography is useful in the diagnosis of complex regional pain syndrome, Type I (formerly reflex sympathetic dystrophy). (17271895)
2004
46
Intravenous regional blocks with guanethidine and prilocaine combined with physiotherapy: two children with complex regional pain syndrome, type 1. (12095024)
2002
47
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. (10870738)
2000
48
Reflex sympathetic dystrophy, sympathetically maintained pain, and complex regional pain syndrome: diagnoses of inclusion, exclusion, or confusion? (11129251)
2000
49
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. (9107464)
1997
50
Complex regional pain syndrome type I (RSD) or peripheral mononeuropathy? A discussion of three cases. (8776555)
1996

Variations for Complex Regional Pain Syndrome

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Expression for genes affiliated with Complex Regional Pain Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for genes affiliated with Complex Regional Pain Syndrome

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 55R&D Systems, 54QIAGEN, 61Thomson Reuters, 56Reactome
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Pathways related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CALCA, EDN1
29.3TNF, IL6
39.3IL6, TNF
4
Show member pathways
IL27-mediated signaling events39
9.3IL6, TNF
59.3IL6, TNF
6
Show member pathways
thioredoxin pathway39
9.3IL6, TNF
7
Show member pathways
Immune response MIF in innate immunity response61
9.3IL6, TNF
8
Show member pathways
9.3TNF, IL6
99.3TNF, IL6
10
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.3IL6, TNF
119.3TNF, IL6
129.3IL6, TNF
139.3IL6, TNF
149.3IL6, TNF
159.3IL6, TNF
169.3TNF, IL6
179.3TNF, IL6
189.0CALCA, IL6, TNF
19
Show member pathways
8.9TNF, CXCR3, IL6
20
Show member pathways
8.9TNF, CXCR3, IL6
218.9IL6, TNF, EDN1
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.9EDN1, TNF, IL6
23
Show member pathways
8.5IL6, CXCR3, TNF, EDN1
24
Show member pathways
8.4EDN1, HCRT, CXCR3, CALCA
25
Show member pathways
8.4CALCA, CXCR3, HCRT, EDN1

Compounds for genes affiliated with Complex Regional Pain Syndrome

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1rantes4610.2CXCR3
2meclofenamate4610.0CALCA, EDN1
3cromakalim46 3011.0CALCA, EDN1
4thiorphan46 30 1211.8EDN1, CALCA
5mcp 1469.8IL6, CXCR3
6pamidronate46 52 1211.8IL6, CALCA
7n(g)-nitro-l-arginine methyl ester469.8CALCA, EDN1
8clodronate46 52 1211.8IL6, CALCA
9cicaprost46 3010.7EDN1, TNF
10tocilizumab46 1210.7TNF, IL6
11abatacept46 1210.7TNF, IL6
12cdp571469.7IL6, TNF
13tenidap46 3010.7TNF, IL6
14anakinra46 1210.7IL6, TNF
15taurine chloramine469.7IL6, TNF
16vesnarinone469.7TNF, IL6
17gabexate mesilate469.6IL6, TNF
18ulinastatin469.6TNF, IL6
19mip 1alpha469.6IL6, TNF
20pmma469.5CALCA, IL6
21il-12469.4IL6, TNF
22groalpha469.4CXCR3, IL6, TNF
23etanercept46 52 1211.4TNF, CXCR3, IL6
24il 10469.3IL6, CXCR3, TNF
25infliximab46 52 1211.3CXCR3, IL6, TNF
26ng-nitro-l-arginine469.3EDN1, CALCA
27ccl346 3010.3TNF, IL6, CXCR3
28adalimumab46 52 1211.3IL6, TNF
298-isoprostane469.3TNF, EDN1, IL6
30endotoxin469.3IL6, CXCR3, TNF
31atorvastatin46 52 30 25 1213.3EDN1, TNF, IL6
32tetrodotoxin46 62 3011.2CALCA, HCRT, EDN1
33herbimycin a46 6210.2EDN1, TNF, IL6
34calcitriol46 62 25 1212.2IL6, TNF, CALCA
355-hydroxytryptamine469.2HCRT, CALCA, EDN1
36creatinine469.1CALCA, IL6, CXCR3, EDN1
37acth469.0CALCA, IL6, HCRT
38hydrocortisone46 3 62 1212.0CXCR3, IL6, TNF, CALCA
39indomethacin46 30 62 1211.9EDN1, TNF, IL6, CALCA
40cyclosporin a46 30 6210.9IL6, EDN1, TNF, CALCA
41pd 98,059468.9IL6, CXCR3, TNF, EDN1
42thymidine46 259.9IL6, CXCR3, EDN1, TNF
43epinephrine46 25 1210.7IL6, CALCA, HCRT, EDN1
44norepinephrine46 25 1210.7IL6, HCRT, CALCA, EDN1
45pge2468.5CXCR3, EDN1, CALCA, IL6, TNF
46vegf468.5EDN1, TNF, CXCR3, IL6, CALCA
47dexamethasone46 52 30 1211.4HCRT, TNF, CXCR3, IL6
48estrogen468.3CALCA, IL6, CXCR3, HCRT
49histamine46 30 259.7HCRT, CALCA, IL6, CXCR3, TNF, EDN1
50nitric oxide46 25 129.7IL6, EDN1, TNF, CXCR3, CALCA, HCRT

GO Terms for genes affiliated with Complex Regional Pain Syndrome

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17Gene Ontology
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Cellular components related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6TNF, CXCR3, IL6
2extracellular regionGO:0055768.6IL6, HCRT, EDN1
3extracellular spaceGO:0056158.5CALCA, IL6, TNF, EDN1

Biological processes related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.0CALCA, EDN1
2monocyte chemotaxisGO:0025489.9CALCA, IL6
3negative regulation of hormone secretionGO:0468889.9EDN1, IL6
4response to heatGO:0094089.8IL6, CALCA
5response to amino acidGO:0432009.8IL6, EDN1
6cell growthGO:0160499.7IL6, EDN1
7positive regulation of JUN kinase activityGO:0435079.7TNF, EDN1
8positive regulation of mitosisGO:0458409.7EDN1, TNF
9negative regulation of lipid storageGO:0108889.7IL6, TNF
10epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7IL6, TNF
11positive regulation of chemokine productionGO:0327229.7TNF, IL6
12positive regulation of MAP kinase activityGO:0434069.6TNF, EDN1
13defense response to Gram-positive bacteriumGO:0508309.6IL6, TNF
14negative regulation of fat cell differentiationGO:0455999.6IL6, TNF
15positive regulation of interleukin-6 productionGO:0327559.6IL6, TNF
16positive regulation of peptidyl-serine phosphorylationGO:0331389.5IL6, TNF
17positive regulation of transmission of nerve impulseGO:0519719.5HCRT, IL6
18response to mechanical stimulusGO:0096129.5IL6, TNF
19protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.5EDN1, HCRT
20humoral immune responseGO:0069599.4IL6, TNF
21positive regulation of protein kinase B signalingGO:0518979.4IL6, TNF
22calcium-mediated signalingGO:0197229.4EDN1, TNF, CXCR3
23response to glucocorticoidGO:0513849.3TNF, IL6
24neuropeptide signaling pathwayGO:0072189.3CALCA, HCRT
25positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, TNF, EDN1
26positive regulation of cell proliferationGO:0082849.3EDN1, CXCR3, IL6
27positive regulation of smooth muscle cell proliferationGO:0486619.3IL6, TNF, EDN1
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2IL6, TNF
29positive regulation of ERK1 and ERK2 cascadeGO:0703749.0IL6, TNF
30inflammatory responseGO:0069548.9CALCA, IL6, CXCR3, TNF
31positive regulation of cytosolic calcium ion concentrationGO:0072048.8CALCA, CXCR3, HCRT, EDN1

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CALCA, EDN1
2cytokine activityGO:0051258.6IL6, TNF, EDN1

Products for genes affiliated with Complex Regional Pain Syndrome

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Sources for Complex Regional Pain Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet