Complex Regional Pain Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Complex Regional Pain Syndrome

MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 72 49 50 40 14
Complex Regional Pain Syndromes 12 51 41 69
Reflex Sympathetic Dystrophy 49 69
Crps 49


External Ids:

Disease Ontology 12 DOID:3223
MeSH 41 D020918
SNOMED-CT 64 128200000
UMLS 69 C0458219

Summaries for Complex Regional Pain Syndrome

NIH Rare Diseases : 49 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is often not known. Two classifications of CRPS have been recognized based on causalgia. Type I (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and Type II, in which peripheral nerve injury is present. Treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy; and/or a sympathetic nerve block. Last updated: 1/9/2017

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and paine syndrome, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related phenotype is integument.

MedlinePlus : 40 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally it goes away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

NINDS : 50 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

Wikipedia : 72 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a disorder... more...

Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 33.7 CALCA NPY
2 paine syndrome 31.7 IL1B SCN9A TAC1
3 burns 30.4 IL1B TNF
4 choroiditis 30.2 IL10 TNF
5 migraine with or without aura 1 30.1 CALCA TAC1 TNF
6 carpal tunnel syndrome 30.1 IL1B IL6 TAC1
7 spondylitis 29.9 HLA-B IL6 TNF
8 headache 29.9 CALCA TAC1 TNF
9 somatoform disorder 29.8 IL1B SCN9A TAC1
10 psoriatic arthritis 29.8 HLA-B IL1B TNF
11 crohn's disease 29.6 IL10 IL1B IL6 TNF
12 major depressive disorder 29.5 IL1B IL6 NPY TNF
13 autoimmune disease 29.3 HLA-B IL10 IL1B IL6 TNF
14 arthritis 29.2 CCL2 IL10 IL1B IL6 TNF
15 causalgia 12.0
16 thoracic outlet syndrome 11.2
17 episodic pain syndrome, familial, 1 11.1
18 autonomic nervous system disease 10.9
19 peripheral nervous system disease 10.9
20 scorpion envenomation 10.6 IL6 TNF
21 punctate inner choroidopathy 10.6 IL10 TNF
22 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
23 critical limb ischemia 10.5 IL6 TNF
24 tropical endomyocardial fibrosis 10.5 IL10 TNF
25 bullous impetigo 10.5 CALCA IL6
26 streptococcal toxic-shock syndrome 10.5 IL6 TNF
27 null-cell leukemia 10.5 IL6 TNF
28 eye lymphoma 10.5 IL10 IL6
29 multifocal choroiditis 10.5 IL10 TNF
30 tungiasis 10.5 IL10 TNF
31 endomyocardial fibrosis 10.5 IL10 TNF
32 acute transverse myelitis 10.5 IL10 IL6
33 tympanosclerosis 10.5 CALCA TNF
34 transient hypogammaglobulinemia 10.5 IL10 TNF
35 polyposis, gastric 10.5 IL1B TNF
36 recurrent corneal erosion 10.5 IL1B IL6
37 bagassosis 10.5 IL1B IL6
38 retinitis pigmentosa 55 10.5 IL6 TNF
39 burn scar 10.5 CALCA TAC1
40 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
41 algoneurodystrophy 10.5
42 staphylococcal toxic shock syndrome 10.5 IL1B TNF
43 immune suppression 10.5 IL10 IL6
44 periodontitis, chronic 10.5 IL1B IL6
45 kashin-beck disease 10.4 IL1B TNF
46 glossitis 10.4 IL6 TNF
47 leprosy 2 10.4 CALCA NPY
48 vulvar vestibulitis syndrome 10.4 IL1B TNF
49 listeriosis 10.4 IL10 IL6 TNF
50 transverse myelitis 10.4 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:

Diseases related to Complex Regional Pain Syndrome

Symptoms & Phenotypes for Complex Regional Pain Syndrome

UMLS symptoms related to Complex Regional Pain Syndrome:

sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, neuralgia, headache, back pain

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 IL10 IL1B IL6 MME SCN9A TAC1

Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational Phase 4,Phase 3 38396-39-3, 2180-92-9 2474
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
Acetaminophen Approved Phase 4 103-90-2 1983
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 54670067 5785
11 Antioxidants Phase 4,Phase 3
12 Micronutrients Phase 4,Phase 3
13 Protective Agents Phase 4,Phase 3
14 Trace Elements Phase 4,Phase 3
15 Vitamins Phase 4,Phase 3
16 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
17 Anesthetics Phase 4,Phase 3,Phase 2
18 Anesthetics, Local Phase 4,Phase 3
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
20 Neurotransmitter Agents Phase 4,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
22 Psychotropic Drugs Phase 4,Phase 2
23 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
25 triamcinolone acetonide Phase 4,Phase 3
26 Triamcinolone diacetate Phase 4,Phase 3
27 Triamcinolone hexacetonide Phase 4,Phase 3
28 Anti-Anxiety Agents Phase 4,Phase 2
29 Anti-Arrhythmia Agents Phase 4,Phase 2
30 Anticonvulsants Phase 4,Phase 2
31 Antimanic Agents Phase 4
32 Antiparkinson Agents Phase 4
33 calcium channel blockers Phase 4,Phase 2
34 Calcium, Dietary Phase 4,Phase 3,Phase 2
35 Diuretics, Potassium Sparing Phase 4
36 Excitatory Amino Acid Antagonists Phase 4,Phase 2
37 Excitatory Amino Acids Phase 4,Phase 2
38 GABA Agents Phase 4
39 Sodium Channel Blockers Phase 4
40 Tranquilizing Agents Phase 4,Phase 2
41 calcitonin Phase 4
42 Calcitonin Gene-Related Peptide Phase 4
43 Vasodilator Agents Phase 4,Phase 2
44 Adjuvants, Anesthesia Phase 4,Phase 3
45 Analgesics, Opioid Phase 4,Phase 3
46 Anesthetics, General Phase 4,Phase 3,Phase 2
47 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
48 Narcotics Phase 4,Phase 3
49 Antipyretics Phase 4
Ropivacaine Approved Phase 3 84057-95-4 175805 71273

Interventional clinical trials:

(show top 50) (show all 118)

# Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
6 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
7 Study on Impact of Fentanyl Matrix on Improvement of Pain and Functioning in Spinal Disorder-related Pain Completed NCT00797017 Phase 4 fentanyl;fentanyl;fentanyl;fentanyl;fentanyl;fentanyl;fentanyl
8 A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Completed NCT00642837 Phase 4 Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen
9 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Not yet recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
10 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
11 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
12 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
13 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
14 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
15 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
16 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
17 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
18 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
19 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
20 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
21 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
22 Safety of Intravenous Neridronic Acid in CRPS Active, not recruiting NCT02972359 Phase 3 Neridronic acid
23 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Terminated NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
24 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
25 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
26 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
27 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
28 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
29 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
30 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
31 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
32 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
33 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
34 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
35 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
36 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
37 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
38 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
39 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
40 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
41 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
42 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329
43 Neurophysiological Basis of Rehabilitation in Complex Regional Pain Syndrome, Type I and Chronic Low Back Pain Unknown status NCT02347579
44 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 placebo
45 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715
46 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783
47 Structural and Functional Nerve Changes Following Immobilisation After Distal Radius Fracture - a Pilot Study (NRP) Unknown status NCT02396277
48 Multi-disciplinary Prevention Program Unknown status NCT02563431
49 Near-infrared Spectroscopic Measurement in Complex Regional Pain Syndrome Completed NCT01586377
50 Evaluation of the Physiodoloris Pain Monitor in Patients With Complex Regional Pain Syndrome Completed NCT02663284 Ropivacaine 0.5%

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :

Cochrane evidence based reviews: complex regional pain syndromes

Genetic Tests for Complex Regional Pain Syndrome

Anatomical Context for Complex Regional Pain Syndrome

MalaCards organs/tissues related to Complex Regional Pain Syndrome:

Skin, Spinal Cord, Bone, Testes, Cortex, Dorsal Root Ganglion, Heart

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 782)
# Title Authors Year
Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia. ( 29419627 )
Utility of Radionuclide Bone Scintigraphy in Complex Regional Pain Syndrome. ( 29388057 )
The Legal Doctrine on the Liability of Physicians in Medical Malpractice Lawsuits Involving Complex Regional Pain Syndrome. ( 29441736 )
Complex Regional Pain Syndrome, Current Concepts and Treatment Options. ( 29404787 )
The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis. ( 29404715 )
Abstracts from Proceedings Cork CRPS 2017: IASP Special Interest Group in Complex Regional Pain Syndrome (CRPS). ( 29430563 )
Signs and Symptoms in 1043 Patients with Complex Regional Pain Syndrome (CRPS). ( 29409933 )
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study. ( 29336203 )
Fear of movement modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): A single-case study. ( 29317053 )
Pain Exposure Physical Therapy versus conventional treatment in complex regional pain syndrome type 1-a cost-effectiveness analysis alongside a randomized controlled trial. ( 29430970 )
Complex Regional Pain Syndrome after Total Knee Arthroplasty is Rare and Misdiagnosis Potentially Hazardous-Prospective Study of the New Diagnostic Criteria in 100 Patients with No Cases Identified. ( 29294499 )
Complex Regional Pain Syndrome Type 1: Diagnosis and Management. ( 29409405 )
Correlates and importance of neglect-like symptoms in Complex Regional Pain Syndrome. ( 29419655 )
Including Parents in the Treatment of Pediatric Complex Regional Pain Syndrome. ( 29406662 )
Complex Regional Pain Syndrome (CRPS): High risk of CRPS after trauma in another limb in patients who already have CRPS in one hand or foot: Lasting changes in neural pain modulating systems? ( 28850440 )
Home training in sensorimotor discrimination reduces pain in complex regional pain syndrome (CRPS). ( 28850333 )
Is the Pain Medicine Community Reluctant to Discuss Limb Amputation in Patients with Intractable Complex Regional Pain Syndrome? ( 28082526 )
Qualitative pain research emphasizes that patients need true information and physicians and nurses need more knowledge of complex regional pain syndrome (CRPS). ( 28850331 )
Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I). ( 28914784 )
Complex regional pain syndrome induced by pacemaker implantation for sick sinus syndrome. ( 29255517 )
The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture. ( 28691512 )
Neurogenic Edema from Complex Regional Pain Syndrome Resulting in Fulminant Infection Necessitating Below Elbow Amputation. ( 29302140 )
[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study. ( 28072713 )
Sex differences in complex regional pain syndrome type I (CRPS-I) in mice. ( 28831269 )
The risk of pain syndrome affecting a previously non-painful limb following trauma or surgery in patients with a history of complex regional pain syndrome. ( 28850441 )
Complex Regional Pain Syndrome following an Episode of Herpes Zoster: A Case Report. ( 28819596 )
Molecular signature of complex regional pain syndrome (CRPS) and its analysis. ( 28803495 )
Autonomic components of Complex Regional Pain Syndrome (CRPS) are favourably affected by Electrical Twitch-Obtaining Intramuscular Stimulation (ETOIMS): effects on blood pressure and heart rate. ( 29445517 )
Complex regional pain syndrome: medical and legal ramifications of clinical variability and experience and perspective of a practicing clinician. ( 28031726 )
High Frequency Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Report. ( 28072810 )
Ultrasound-guided pulsed radiofrequency treatment of the cervical sympathetic chain for complex regional pain syndrome: A retrospective observational study. ( 28072749 )
Biased visuospatial perception in complex regional pain syndrome. ( 28852115 )
Passive transfer autoimmunity in a mouse model of complex regional pain syndrome. ( 28891866 )
Effects of Simvastatin Beyond Dyslipidemia: Exploring Its Antinociceptive Action in an Animal Model of Complex Regional Pain Syndrome-Type I. ( 28928655 )
Different patterns in mental rotation of facial expressions in complex regional pain syndrome patients. ( 28953620 )
Hand lesion after arthroscopic rotator cuff repair: Association with complex regional pain syndrome. ( 28947243 )
Complex Regional Pain Syndrome Type I, a Debilitating and Poorly Understood Syndrome. Possible Role for Pulsed Electromagnetic Fields: A Narrative Review. ( 28934787 )
Perioperative Management of a Parturient with Complex Regional Pain Syndrome for Elective C-Section. ( 29303238 )
Complex regional pain syndrome-up-to-date. ( 29392238 )
Intrathecal management of complex regional pain syndrome: A case report and literature. ( 28850424 )
Complex regional pain syndrome as an unusual cause of delirium in a dementia patient. ( 29424880 )
Pain reduction due to novel sensory-motor training in Complex Regional Pain Syndrome I - A pilot study. ( 28850342 )
Abdominal wall Type-I complex regional pain syndrome treated effectively with peripheral nerve field stimulation: a case report. ( 28044002 )
Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis. ( 28774452 )
Three cases of type-1 complex regional pain syndrome after elective total hip replacement. ( 28862131 )
Pain, Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, RSD, CRPS) ( 28613470 )
Adult Complex Regional Pain Syndrome Type I: A Narrative Review. ( 27890578 )
Multicenter study on the asymmetry of skin temperature in complex regional pain syndrome: An examination of temperature distribution and symptom duration. ( 28033251 )
Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome. ( 27919822 )

Variations for Complex Regional Pain Syndrome

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
Show member pathways
13.29 CCL2 HLA-B IL10 IL1B IL6 TNF
Show member pathways
12.91 CCL2 EDN1 IL1B IL6 TNF
Show member pathways
12.8 HLA-B IL10 IL1B IL6 TNF
Show member pathways
Show member pathways
12.56 CCL2 IL10 IL1B IL6 TNF
Show member pathways
12.53 IL10 IL1B IL6 TNF
8 12.5 CCL2 IL10 IL1B TNF
Show member pathways
12.49 CCL2 IL10 IL1B IL6 TNF
Show member pathways
12.39 IL10 IL1B IL6 TNF
Show member pathways
12.3 CCL2 IL1B IL6 TNF
Show member pathways
12.29 CCL2 IL1B IL6 TNF
13 12.2 IL10 IL1B IL6 TNF
14 12.13 IL10 IL1B IL6 TAC1 TNF
Show member pathways
12.1 HLA-B IL10 IL1B IL6 TNF
16 12.08 CCL2 EDN1 IL1B TNF
17 11.99 CCL2 IL1B IL6 TNF
18 11.96 IL10 IL6 MME TNF
Show member pathways
11.91 IL10 IL1B IL6 TNF
20 11.89 CCL2 IL10 IL1B IL6 TNF
21 11.87 IL1B IL6 MME TNF
22 11.86 IL10 IL1B IL6 TNF
23 11.84 CCL2 EDN1 IL1B IL6 TNF
24 11.82 CCL2 IL1B IL6 TNF
25 11.76 IL10 IL1B TNF
26 11.73 IL10 IL1B IL6 TNF
27 11.72 CCL2 EDN1 IL1B IL6 TNF
28 11.67 IL10 IL6 TNF
Show member pathways
11.64 IL1B IL6 TNF
30 11.57 IL1B IL6 TNF
31 11.52 IL10 IL1B IL6 MME TNF
32 11.5 CCL2 IL1B TNF
33 11.46 CALCA IL1B IL6 TNF
34 11.35 CALCA EDN1 NPY
35 11.32 IL10 IL1B IL6 TNF
36 11.3 IL1B IL6 TNF
37 11.3 IL10 IL1B IL6 TNF
38 11.28 IL1B IL6 TNF
39 11.24 CCL2 IL10 IL1B IL6 TNF
40 11.16 CCL2 IL10 IL1B IL6 TNF
41 11.15 IL10 IL1B IL6 TNF
42 11.05 IL1B TNF
43 11.05 IL6 TNF
44 11.04 CCL2 IL10 IL1B IL6 TNF
45 10.98 IL6 TNF
46 10.98 CCL2 IL10 IL1B IL6 TNF
47 10.94 CCL2 IL1B TNF
49 10.77 IL1B IL6

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA CCL2 EDN1 IL10 IL1B IL6
2 extracellular space GO:0005615 9.28 CALCA CCL2 EDN1 IL10 IL1B IL6

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.88 EDN1 IL10 IL1B TAC1
2 immune response GO:0006955 9.88 CCL2 HLA-B IL10 IL1B IL6 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B IL6 TNF
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.87 CALCA EDN1 TAC1
5 neuron projection development GO:0031175 9.86 IL6 NPY TOR1A
6 cellular response to tumor necrosis factor GO:0071356 9.86 CALCA CCL2 EDN1
7 cell-cell signaling GO:0007267 9.85 CALCA EDN1 IL10 IL1B TAC1
8 neuropeptide signaling pathway GO:0007218 9.83 CALCA NPY TAC1
9 cellular response to organic cyclic compound GO:0071407 9.81 CCL2 IL1B TNF
10 neutrophil chemotaxis GO:0030593 9.8 CCL2 EDN1 IL1B
11 response to glucocorticoid GO:0051384 9.79 IL10 IL6 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 EDN1 IL6 TNF
13 cellular response to lipopolysaccharide GO:0071222 9.78 CCL2 IL10 IL6 TNF
14 humoral immune response GO:0006959 9.77 CCL2 IL6 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.75 IL1B IL6 TNF
16 protein kinase B signaling GO:0043491 9.73 CCL2 IL1B TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 EDN1 IL1B TNF
18 monocyte chemotaxis GO:0002548 9.71 CALCA CCL2 IL6
19 response to pain GO:0048265 9.7 CALCA TAC1
20 positive regulation of chemokine production GO:0032722 9.69 IL6 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
23 positive regulation of ossification GO:0045778 9.68 CALCA TAC1
24 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 IL1B TNF
26 positive regulation of renal sodium excretion GO:0035815 9.67 EDN1 TAC1
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TNF
28 regulation of blood pressure GO:0008217 9.67 CALCA EDN1 NPY TAC1
29 negative regulation of bone resorption GO:0045779 9.66 CALCA IL6
30 positive regulation of acute inflammatory response GO:0002675 9.65 IL6 TAC1
31 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
33 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
34 positive regulation of prostaglandin secretion GO:0032308 9.63 EDN1 IL1B
35 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
37 positive regulation of interleukin-8 production GO:0032757 9.61 CALCA IL1B TNF
38 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
39 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
40 sensory perception of pain GO:0019233 9.56 EDN1 MME SCN9A TAC1
41 regulation of receptor activity GO:0010469 9.56 CALCA CCL2 EDN1 IL10 IL1B IL6
42 positive regulation of DNA binding transcription factor activity GO:0051091 9.55 EDN1 IL10 IL1B IL6 TNF
43 receptor biosynthetic process GO:0032800 9.52 IL10 TNF
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IL1B TNF
45 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
46 inflammatory response GO:0006954 9.23 CALCA CCL2 IL10 IL1B IL6 SCN9A

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.43 CALCA CCL2 EDN1 HLA-B NPY TAC1
2 hormone activity GO:0005179 9.33 CALCA EDN1 NPY
3 cytokine activity GO:0005125 9.1 CCL2 EDN1 IL10 IL1B IL6 TNF

Sources for Complex Regional Pain Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
51 Novoseek
54 OMIM via Orphanet
58 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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