CRPS
MCID: CMP010
MIFTS: 65

Complex Regional Pain Syndrome (CRPS) malady

Neuronal diseases category

Summaries for Complex Regional Pain Syndrome

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to pain disorder and migraine. An important gene associated with Complex Regional Pain Syndrome is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and NK1R-mediated Non-Apoptotic PCD. The compounds methoxamine and helospectin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and spinal cord, and related mouse phenotypes are skeleton and renal/urinary system.

NIH Rare Diseases:42 Complex regional pain syndrome is a chronic pain condition that mainly affects the arms or legs and is often triggered by injury. it is characterized by constant pain, sensitivity, and skin color and temperature changes at the site of an injury. the pain is out of proportion to the severity of the injury and worsens with time. treatment aims to control these painful symptoms. last updated: 10/19/2011

MedlinePlus:33 Complex regional pain syndrome (crps) is a chronic pain condition. it causes intense pain, usually in the arms, hands, legs, or feet. it may happen after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. symptoms in the affected area are dramatic changes in skin temperature, color, or texture intense burning pain extreme skin sensitivity swelling and stiffness in affected joints decreased ability to move the affected body part the cause of crps is unknown. there is no specific diagnostic test. your doctor will diagnose crps based on your signs and symptoms. there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. nih: national institute of neurological disorders and stroke

Wikipedia:63 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Description from OMIM:46 604335

Aliases & Classifications for Complex Regional Pain Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
complex regional pain syndrome:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

complex regional pain syndrome 8 42 43 10 48 46 33
complex regional pain syndromes 8 44 60
reflex sympathetic dystrophy 10 44 60
reflex sympathetic dystrophy syndrome 42 43
crps 42


External Ids:

Disease Ontology8 DOID:3223
MeSH34 D020918
MESH via Orphanet35 D020918
ICD10 via Orphanet26 G56.4, M89.0
SNOMED-CT56 128200000
SNOMED-CT via Orphanet57 128200000
UMLS via Orphanet61 C0458219
OMIM46 604335

Related Diseases for Complex Regional Pain Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Complex Regional Pain Syndrome family:

Complex Regional Pain Syndrome Type 1

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 609)
idRelated DiseaseScoreTop Affiliating Genes
1pain disorder30.8TAC1
2migraine30.5CALCA, NPS, HCRT, TAC1, TACR1
3obesity30.5TNF, NPY, HCRT, IL6, ADRB2
4atherosclerosis30.4TNF, EDN1, CXCR3, CXCL9, IL6, ADRB2
5hypertension30.4CALCA, NPY, EDN1, TAC1, ADRB2
6neuropathy30.4TAC1, CALCA
7systemic lupus erythematosus30.3TNF, CXCR3, IL6, FCGR3A, ADRB2
8acute myocardial infarction30.3EDN1, ADRB2
9myocardial infarction30.3ADRB2, LPO, EDN1, NPY
10periodontitis30.2TNF, IL6, FCGR3A
11rheumatoid arthritis30.2TNF, CXCR3, CXCL9, IL6, TAC1, TACR1
12crohn's disease30.2TNF
13acute pancreatitis30.2TACR1, IL6
14vascular disease30.2TNF, NPS, IL6
15pancreatitis30.2TACR1, TAC1, IL6
16pneumonia30.2IL6, TNF
17periodontal disease30.2IL6, TNF
18ankylosing spondylitis30.2TNF
19ischemia30.2EDN1, HCRT, ADRB2
20adenocarcinoma30.2ADRB2, TACR1, TAC1
21pain agnosia30.2CALCA, NPS, TAC1, TACR1
22arthritis30.1ADRB2, FCGR3A, TACR1, TAC1, IL6, CXCL9
23meningitis30.1IL6
24peritonitis30.1TNF, IL6
25ulcerative colitis30.1TNF, CXCR3, IL6, TAC1, TACR1
26diabetes mellitus30.1CALCA, TNF, NPS, NPY, EDN1, IL6
27essential hypertension30.1ADRB2, EDN1, NPY
28osteoarthritis30.0CALCA, TNF, NPY, CXCR3, IL6, TAC1
29neutropenia30.0FCGR3A
30bronchiolitis obliterans30.0CXCR3
31synovitis30.0IL6, TNF
32sepsis30.0CALCA, TNF, CXCL9, IL6, FCGR3A, ADRB2
33inflammatory bowel disease30.0TNF, IL6, TAC1, TACR1
34alzheimer's disease30.0NPS, NPY, HCRT, CXCR3, IL6, TACR1
35encephalitis29.9CXCL9
36dementia29.9HCRT
37hypercholesterolemia29.9EDN1
38irritable bowel syndrome29.9TAC1
39thyroiditis29.9CALCA
40sleep disorder29.9NPS, HCRT
41diarrhea29.9TAC1, CALCA
42respiratory failure29.9IL6, NPY, TNF
43uveitis29.9TNF, CXCR3, CXCL9
44coronary heart disease29.9NPY, EDN1, IL6, ADRB2
45rheumatic disease29.9ADRB2, CXCR3, TNF
46pre-eclampsia29.9ADRB2, TAC1, IL6, EDN1
47insulin resistance29.9TNF, NPY, EDN1, IL6, TAC1, ADRB2
48breast cancer29.9TAC1, CXCL9, CXCR3, LPO, CALCA
49asthma29.9TNF, NPS, EDN1, LPO, CXCR3, CXCL9
50interstitial lung disease29.8TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to complex regional pain syndrome

Clinical Features for Complex Regional Pain Syndrome

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46OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Complex Regional Pain Syndrome

Drug clinical trials:

Search ClinicalTrials for Complex Regional Pain Syndrome

Search NIH Clinical Center for Complex Regional Pain Syndrome

Search CenterWatch for Complex Regional Pain Syndrome

Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

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Sources:
32MalaCards
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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

32
Skin, Testes, Spinal cord, Bone, Cortex, Brain, Monocytes, Cingulate cortex, Thalamus, Heart, Eye, Endothelial, Lung, Skeletal muscle, Pituitary

Animal Models for Complex Regional Pain Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.1NPY, IL6, TACR1, ADRB2
2MP:000536710.0NPY, EDN1, TAC1, ADRA1A
3MP:00053699.8TNF, GABPA, EDN1, HCRT, IL6, SGCE
4MP:00036319.5TNF, NPY, GABPA, EDN1, HCRT, IL6
5MP:00053859.5ADRB2, CALCA, TNF, EDN1, HCRT, CXCR3
6MP:00053869.4CALCA, TNF, NPY, HCRT, IL6, TAC1
7MP:00053769.4EDN1, GABPA, NPY, TNF, CALCA, HCRT
8MP:00053879.2TNF, GABPA, CXCR3, CXCL9, IL6, TACR1

Publications for Complex Regional Pain Syndrome

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50PubMed
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Articles related to Complex Regional Pain Syndrome:

(show top 50)    (show all 596)
idTitleAuthorsYear
1
Evaluation of the structural quality of bone in a case of progressive osteoporosis complicating a Complex Regional Pain Syndrome (CRPS) of the upper limb. (24200752)
2014
2
Concurrence of malignant peripheral nerve sheath tumor at the site of complex regional pain syndrome type 1 - a case report -. (23614078)
2013
3
Cutaneous noradrenaline measured by microdialysis in complex regional pain syndrome during whole-body cooling and heating. (23357619)
2013
4
Underlying synovial sarcoma in a patient with a history of complex regional pain syndrome: a case report. (23158107)
2013
5
Designing and Delivering an Educational Package to Meet the Needs of Primary Care Health Professionals in the Diagnosis and Management of those with Complex Regional Pain Syndrome. (23878022)
2013
6
Genome-wide expression profiling of complex regional pain syndrome. (24244504)
2013
7
Diffuse complex regional pain syndrome in an adolescent: a novel treatment approach. (23823251)
2013
8
Interventions for treating pain and disability in adults with complex regional pain syndrome. (23633371)
2013
9
Analysis of patterns of three-phase bone scintigraphy for patients with complex regional pain syndrome diagnosed using the proposed research criteria (the 'Budapest Criteria'). (22293544)
2012
10
Still's Disease and Recurrent Complex Regional Pain Syndrome Type-I: The First Description. (22162802)
2012
11
Morphine and memantine treatment of long-standing complex regional pain syndrome. (22295900)
2012
12
Complex regional pain syndrome following immunisation. (22858647)
2012
13
Motor control in complex regional pain syndrome: a kinematic analysis. (22336720)
2012
14
Is physiotherapy effective for children with complex regional pain syndrome type 1? (21677566)
2012
15
A possible case of complex regional pain syndrome of the nose? (22545389)
2012
16
A case of complex regional pain syndrome with agnosia for object orientation. (21450404)
2011
17
Complex Regional Pain Syndrome (CRPS type-1) in an Adolescent Following Extravasation of Dextrose Containing Fluid-an Underdiagnosed Case. (21716610)
2011
18
Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I. (21880999)
2011
19
Complex regional pain syndrome type I as a consequence of trauma or surgery to upper extremity: management with intravenous regional anaesthesia, using lidocaine and methyloprednisolone. (21719518)
2011
20
Mitochondrial dysfunction in muscle tissue of complex regional pain syndrome type I patients. (21262583)
2011
21
A previously unreported differential diagnosis of the complex regional pain syndrome. (21985021)
2011
22
Evidence based guidelines for complex regional pain syndrome type 1. (20356382)
2010
23
Plasticity of complex regional pain syndrome (CRPS) in children. (20704670)
2010
24
Motor cortex dysfunction in complex regional pain syndrome. (20185362)
2010
25
Coexistence of short fifth metacarpals in a female patient with ankylosing spondylitis associated with complex regional pain syndrome type-I. (21245822)
2010
26
Lower extremity complex regional pain syndrome: long-term outcome after surgical treatment of peripheral pain generators. (20123284)
2010
27
Spontaneous onset of complex regional pain syndrome. (19793666)
2010
28
An update on the pathophysiology of complex regional pain syndrome. (20693883)
2010
29
Poststroke complex regional pain syndrome. (20797958)
2010
30
Sensory disturbances in complex regional pain syndrome: clinical observations, autonomic interactions, and possible mechanisms. (20704674)
2010
31
Complex regional pain syndrome (Type 1) following steroid injection for stenosing tenosynovitis. (20510663)
2010
32
Malignancy as a possible complication of complex regional pain syndrome: a case report. (20002598)
2010
33
Neuropsychological deficits associated with Complex Regional Pain Syndrome. (20298641)
2010
34
Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I). (19878863)
2009
35
Does evidence support physiotherapy management of adult Complex Regional Pain Syndrome Type One? A systematic review. (18619873)
2009
36
Role of biphosphonates and lymphatic drainage type Leduc in the complex regional pain syndrome (shoulder-hand syndrome). (19222778)
2009
37
IgE-mediated hypersensitivity: patients with complex regional pain syndrome type 1 (CRPS1) vs the Dutch population. A retrospective study. (18721169)
2009
38
Effect of spinal cord stimulation in Type I complex regional pain syndrome with 2 rare severe cutaneous manifestations. (18928361)
2009
39
Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome. (18554967)
2009
40
Complex regional pain syndrome in a HIV seropositive patient starting antiretroviral therapy. (20009979)
2009
41
Spinal cord stimulation for complex regional pain syndrome. (19964771)
2009
42
Complex regional pain syndrome type 1. Some treatments assessed versus placebo, limited efficacy. (20027710)
2009
43
Serum and salivary oxidative analysis in Complex Regional Pain Syndrome. (18539395)
2008
44
Extensive skin necrosis of the arm in a patient with complex regional pain syndrome. (18681876)
2008
45
Clinical outcome of cementless semi-constrained trapeziometacarpal arthroplasty, and possible effect of vitamin C on the occurrence of complex regional pain syndrome. (18686455)
2008
46
Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance. (18192313)
2008
47
Impact of three-phase bone scintigraphy on the diagnosis and treatment of complex regional pain syndrome type I or reflex sympathetic dystrophy. (16340227)
2006
48
Reassessment of the incidence of complex regional pain syndrome type 1 following stroke. (11228950)
2000
49
Thermal grill illusion and complex regional pain syndrome type I (reflex sympathetic dystrophy). (9168218)
1997
50
Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. A case report. (9055376)
1997

Genetic Variations for Complex Regional Pain Syndrome

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Expression for genes affiliated with Complex Regional Pain Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for genes affiliated with Complex Regional Pain Syndrome

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Sources:
12EMD Millipore, 51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.2IL6, TNF, CALCA
210.2TACR1, TAC1
310.2TACR1, TAC1
4
Hide members
10.2NPY, ADRA1A, ADRB2
510.1NPY, CALCA, ADRA1A, EDN1
6
Hide members
10.1ADRA1A, ADRB2, IL6, EDN1
710.0TACR1, TAC1, IL6, TNF
8
Hide members
10.0ADRB2, IL6, GABPA, CALCA, ADRA1A
9
Hide members
9.9TACR1, CXCR3, HCRT, NPY, TAC1
10
Hide members
9.8ADRA1A, TACR1, TAC1, HCRT, EDN1, NPS
11
Hide members
9.3NPY, TACR1, ADRA1A, TAC1, ADRB2, CALCA
12
Hide members
9.3CALCA, NPS, NPY, EDN1, ADRB2, ADRA1A

Compounds for genes affiliated with Complex Regional Pain Syndrome

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1methoxamine28 44 1112.5ADRA1A, NPY, EDN1
2helospectin4410.5NPY, CALCA, TAC1
3rp6758044 2811.5TAC1, TACR1, CALCA
4gr 7363244 5911.5CALCA, TACR1, TAC1
5estrogen4410.5TAC1, GCH1
6cromakalim44 2811.5CALCA, TAC1, EDN1
7resiniferatoxin44 2811.5CALCA, TAC1, TACR1
8groalpha4410.5TNF, CXCR3, CXCL9, IL6
9etanercept44 49 1112.5TNF, IL6, CXCR3, FCGR3A
10phenoxybenzamine44 1111.4NPY, ADRB2, TAC1, ADRA1A
11guanethidine44 1111.4TACR1, NPY, CALCA, TAC1
12il 104410.4TNF, IL6, CXCL9, CXCR3
13indomethacin44 59 28 1113.4CALCA, TAC1, NPY, TACR1
14ng-nitro-l-arginine4410.4CALCA, EDN1, TACR1, TAC1
15carbachol44 28 1112.4EDN1, HCRT, NPY, TAC1
16fenoterol44 28 1112.4TAC1, EDN1, ADRB2
17prostaglandin f2alpha4410.4ADRB2, TAC1, EDN1, NPY, CALCA
18phosphoramidon44 1111.4CALCA, TACR1, TAC1, EDN1, NPY
19ccl344 2811.3IL6, CXCL9, CXCR3, TNF
20thapsigargin44 5911.3TACR1, NPY, HCRT
21methacholine44 1111.3CALCA, TAC1, TACR1, ADRB2
22acetylcholine44 49 28 11 2414.3TACR1, TAC1, ADRB2, CALCA, HCRT
23l-nmma4410.3TACR1, TAC1, EDN1, TNF
24clonidine44 28 1112.3NPY, TAC1, CALCA, TACR1
25opiate4410.3HCRT, TAC1, TACR1, ADRB2, NPY
26tetrodotoxin44 59 2812.3CALCA, TAC1, TACR1, HCRT, EDN1, NPY
27isoproterenol44 1111.2TAC1, CALCA, NPY, EDN1, ADRB2
28sodium nitroprusside4410.2TACR1, TAC1, CXCL9, CXCR3, EDN1, NPY
29oxygen44 2411.2TNF, GABPA, INTS7, TACR1, ADRB2, FCGR3A
30adalimumab44 49 1112.2IL6, TNF, FCGR3A
31phentolamine28 44 1112.2NPY, TAC1, ADRA1A
32phenylephrine44 28 11 2413.2NPY, EDN1, HCRT, ADRA1A
33capsaicin44 2811.2NPY, CALCA, TACR1, TAC1
34creatinine4410.2NPY, EDN1, CXCR3, CXCL9, CALCA, IL6
355-hydroxytryptamine4410.2CALCA, HCRT, ADRB2, TACR1, TAC1, NPY
36atropine44 28 1112.2TAC1, NPY, CALCA, TACR1
37prostacyclin4410.1TAC1, TNF, TACR1, NPY, EDN1
38norepinephrine44 11 2412.1NPY, CALCA, GCH1, HCRT, TACR1, TAC1
39pge24410.1EDN1, TACR1, TAC1, IL6, CXCR3, TNF
40dopamine44 28 11 2413.0ADRA1A, ADRB2, TAC1, HCRT, NPY, CALCA
41dexamethasone44 49 28 1113.0IL6, TAC1, TACR1, CXCR3, HCRT, TNF
42arginine449.9ADRB2, NPY, GCH1, FCGR3A, TAC1, CXCL9
43thiorphan44 28 1111.9TAC1, CALCA, EDN1
44lactate449.9IL6, LPO, NPY, TNF, CALCA, ADRB2
45epinephrine44 11 2411.9HCRT, IL6, ADRA1A, LPO, EDN1, CALCA
46histamine44 28 2411.8TAC1, EDN1, HCRT, TACR1, CXCR3, IL6
47tyrosine449.7NPY, GCH1, FCGR3A, LPO, HCRT, CXCR3
48vegf449.7CXCR3, CXCL9, IL6, TNF, ADRB2, CALCA
49nitric oxide44 11 2411.5IL6, CXCL9, ADRB2, GCH1, NPY, CALCA
50calcium44 49 11 2412.4CXCL9, GCH1, CALCA, ADRA1A, FCGR3A, CXCR3

GO Terms for genes affiliated with Complex Regional Pain Syndrome

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16Gene Ontology
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Cellular components related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.0FCGR3A, IL6, CXCL9, CXCR3, TNF
2extracellular regionGO:0055769.3FCGR3A, CALCA, TNF, NPS, NPY, EDN1
3extracellular spaceGO:0056159.3CALCA, TNF, NPY, EDN1, LPO, CXCL9

Biological processes related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transmission of nerve impulseGO:05197110.6HCRT, IL6
2negative regulation of smooth muscle contractionGO:04598610.6CALCA, ADRB2
3positive regulation of nitric oxide biosynthetic processGO:04542910.5IL6, EDN1, TNF
4positive regulation of smooth muscle cell proliferationGO:04866110.5TNF, EDN1, IL6
5calcium-mediated signalingGO:01972210.5TNF, EDN1, CXCR3
6response to painGO:04826510.5TAC1, CALCA, GCH1
7detection of abiotic stimulusGO:00958210.5TACR1, TAC1
8positive regulation of saliva secretionGO:04687810.5TAC1, TACR1
9positive regulation of renal sodium excretionGO:03581510.5EDN1, TAC1, TACR1
10epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.5TNF, IL6
11response to heatGO:00940810.5TACR1, IL6, CALCA
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.5ADRA1A, TACR1, HCRT
13positive regulation of synaptic transmission, cholinergicGO:03222410.5TAC1, TACR1
14positive regulation of synaptic transmission, GABAergicGO:03223010.5NPS, TAC1, TACR1
15negative regulation of lipid storageGO:01088810.4TNF, IL6
16cell growthGO:01604910.4EDN1, IL6, ADRA1A
17positive regulation of lymphocyte proliferationGO:05067110.4TACR1, TAC1
18regulation of blood pressureGO:00821710.4TAC1, NPY, CALCA, GCH1
19response to lipopolysaccharideGO:03249610.4GCH1, EDN1, IL6, TAC1
20positive regulation of MAPK cascadeGO:04341010.4ADRB2, ADRA1A, IL6
21positive regulation of action potentialGO:04576010.4NPS, TAC1, TACR1, ADRA1A
22positive regulation of acute inflammatory responseGO:00267510.3IL6, TAC1
23neuropeptide signaling pathwayGO:00721810.3TAC1, HCRT, NPY, NPS, CALCA
24tachykinin receptor signaling pathwayGO:00721710.3TACR1, TAC1
25cell-cell signalingGO:00726710.3CALCA, EDN1, CXCL9, TAC1, ADRA1A
26positive regulation of hormone secretionGO:04688710.2TACR1, EDN1
27negative regulation of hormone secretionGO:04688810.2IL6, EDN1
28positive regulation of ERK1 and ERK2 cascadeGO:07037410.2ADRA1A, IL6, TNF
29elevation of cytosolic calcium ion concentrationGO:00720410.1ADRA1A, TACR1, TAC1, CXCR3, HCRT, EDN1
30inflammatory responseGO:00695410.1CALCA, TNF, CXCR3, CXCL9, IL6, TAC1
31agingGO:0075689.9CALCA, IL6, ADRA1A

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.1IL6, CXCL9, EDN1, TNF

Products for genes affiliated with Complex Regional Pain Syndrome

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Sources for Complex Regional Pain Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet