CRPS
MCID: CMP010
MIFTS: 65

Complex Regional Pain Syndrome (CRPS) malady

Neuronal diseases category

Summaries for Complex Regional Pain Syndrome

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to pain disorder and migraine. An important gene associated with Complex Regional Pain Syndrome is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and NK1R-mediated Non-Apoptotic PCD. The compounds methoxamine and helospectin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and spinal cord, and related mouse phenotypes are skeleton and renal/urinary system.

NIH Rare Diseases:42 Complex regional pain syndrome is a chronic pain condition that mainly affects the arms or legs and is often triggered by injury. it is characterized by constant pain, sensitivity, and skin color and temperature changes at the site of an injury. the pain is out of proportion to the severity of the injury and worsens with time. treatment aims to control these painful symptoms. last updated: 10/19/2011

MedlinePlus:33 Complex regional pain syndrome (crps) is a chronic pain condition. it causes intense pain, usually in the arms, hands, legs, or feet. it may happen after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. symptoms in the affected area are dramatic changes in skin temperature, color, or texture intense burning pain extreme skin sensitivity swelling and stiffness in affected joints decreased ability to move the affected body part the cause of crps is unknown. there is no specific diagnostic test. your doctor will diagnose crps based on your signs and symptoms. there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. nih: national institute of neurological disorders and stroke

Wikipedia:63 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Description from OMIM:46 604335

Aliases & Classifications for Complex Regional Pain Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
complex regional pain syndrome:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

complex regional pain syndrome 8 42 43 10 48 46 33
complex regional pain syndromes 8 44 60
reflex sympathetic dystrophy 10 44 60
reflex sympathetic dystrophy syndrome 42 43
crps 42


External Ids:

Disease Ontology8 DOID:3223
MeSH34 D020918
MESH via Orphanet35 D020918
ICD10 via Orphanet26 G56.4, M89.0
SNOMED-CT56 128200000
SNOMED-CT via Orphanet57 128200000
UMLS via Orphanet61 C0458219
OMIM46 604335

Related Diseases for Complex Regional Pain Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Complex Regional Pain Syndrome family:

Complex Regional Pain Syndrome Type 1

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 609)
idRelated DiseaseScoreTop Affiliating Genes
1pain disorder30.8TAC1
2migraine30.5CALCA, NPS, HCRT, TAC1, TACR1
3obesity30.5TNF, NPY, HCRT, IL6, ADRB2
4atherosclerosis30.4TNF, EDN1, CXCR3, CXCL9, IL6, ADRB2
5hypertension30.4CALCA, NPY, EDN1, TAC1, ADRB2
6neuropathy30.4TAC1, CALCA
7systemic lupus erythematosus30.3TNF, CXCR3, IL6, FCGR3A, ADRB2
8acute myocardial infarction30.3EDN1, ADRB2
9myocardial infarction30.3ADRB2, LPO, EDN1, NPY
10periodontitis30.2TNF, IL6, FCGR3A
11rheumatoid arthritis30.2TNF, CXCR3, CXCL9, IL6, TAC1, TACR1
12crohn's disease30.2TNF
13acute pancreatitis30.2TACR1, IL6
14vascular disease30.2TNF, NPS, IL6
15pancreatitis30.2TACR1, TAC1, IL6
16pneumonia30.2IL6, TNF
17periodontal disease30.2IL6, TNF
18ankylosing spondylitis30.2TNF
19ischemia30.2EDN1, HCRT, ADRB2
20adenocarcinoma30.2ADRB2, TACR1, TAC1
21pain agnosia30.2CALCA, NPS, TAC1, TACR1
22arthritis30.1ADRB2, FCGR3A, TACR1, TAC1, IL6, CXCL9
23meningitis30.1IL6
24peritonitis30.1TNF, IL6
25ulcerative colitis30.1TNF, CXCR3, IL6, TAC1, TACR1
26diabetes mellitus30.1CALCA, TNF, NPS, NPY, EDN1, IL6
27essential hypertension30.1ADRB2, EDN1, NPY
28osteoarthritis30.0CALCA, TNF, NPY, CXCR3, IL6, TAC1
29neutropenia30.0FCGR3A
30bronchiolitis obliterans30.0CXCR3
31synovitis30.0IL6, TNF
32sepsis30.0CALCA, TNF, CXCL9, IL6, FCGR3A, ADRB2
33inflammatory bowel disease30.0TNF, IL6, TAC1, TACR1
34alzheimer's disease30.0NPS, NPY, HCRT, CXCR3, IL6, TACR1
35encephalitis29.9CXCL9
36dementia29.9HCRT
37hypercholesterolemia29.9EDN1
38irritable bowel syndrome29.9TAC1
39thyroiditis29.9CALCA
40sleep disorder29.9NPS, HCRT
41diarrhea29.9TAC1, CALCA
42respiratory failure29.9IL6, NPY, TNF
43uveitis29.9TNF, CXCR3, CXCL9
44coronary heart disease29.9NPY, EDN1, IL6, ADRB2
45rheumatic disease29.9ADRB2, CXCR3, TNF
46pre-eclampsia29.9ADRB2, TAC1, IL6, EDN1
47insulin resistance29.9TNF, NPY, EDN1, IL6, TAC1, ADRB2
48breast cancer29.9TAC1, CXCL9, CXCR3, LPO, CALCA
49asthma29.9TNF, NPS, EDN1, LPO, CXCR3, CXCL9
50interstitial lung disease29.8TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to complex regional pain syndrome

Clinical Features for Complex Regional Pain Syndrome

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46OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Complex Regional Pain Syndrome

Drug clinical trials:

Search ClinicalTrials for Complex Regional Pain Syndrome

Search NIH Clinical Center for Complex Regional Pain Syndrome

Search CenterWatch for Complex Regional Pain Syndrome

Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

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32MalaCards
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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

32
Skin, Testes, Spinal cord, Bone, Cortex, Brain, Monocytes, Cingulate cortex, Thalamus, Heart, Eye, Endothelial, Lung, Skeletal muscle, Pituitary

Animal Models for Complex Regional Pain Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.1NPY, IL6, TACR1, ADRB2
2MP:000536710.0NPY, EDN1, TAC1, ADRA1A
3MP:00053699.8TNF, GABPA, EDN1, HCRT, IL6, SGCE
4MP:00036319.5TNF, NPY, GABPA, EDN1, HCRT, IL6
5MP:00053859.5ADRB2, CALCA, TNF, EDN1, HCRT, CXCR3
6MP:00053869.4CALCA, TNF, NPY, HCRT, IL6, TAC1
7MP:00053769.4EDN1, GABPA, NPY, TNF, CALCA, HCRT
8MP:00053879.2TNF, GABPA, CXCR3, CXCL9, IL6, TACR1

Publications for Complex Regional Pain Syndrome

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50PubMed
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Articles related to Complex Regional Pain Syndrome:

(show top 50)    (show all 596)
idTitleAuthorsYear
1
Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. (23267031)
2013
2
A case of recurrent complex regional pain syndrome accompanying Raynaud's disease: a prospective coincidence? (23720085)
2013
3
Appearance of burning abdominal pain during cesarean section under spinal anesthesia in a patient with complex regional pain syndrome: a case report. (23198747)
2013
4
Report of a preliminary discontinued double-blind, randomized, placebo-controlled trial of the anti-TNF-I+ chimeric monoclonal antibody infliximab in complex regional pain syndrome. (23692303)
2013
5
The role of pain coping and kinesiophobia in patients with complex regional pain syndrome type 1 of the legs. (23739533)
2013
6
Usefulness of thermography in diagnosis of complex regional pain syndrome type I after transradial coronary intervention. (23995728)
2013
7
Ten years of successful pain management for complex regional pain syndrome by epidural anesthesia with implanted port: a case report. (23674103)
2013
8
Intravenous magnesium for chronic complex regional pain syndrome type 1 (CRPS-1). (23889940)
2013
9
Muscle hyperalgesia correlates with motor function in complex regional pain syndrome type 1. (23541068)
2013
10
An explanatory study evaluating the muscle relaxant effects of intramuscular magnesium sulphate for dystonia in complex regional pain syndrome. (23954520)
2013
11
Transitioning from a hospital rehabilitation programme to home: exploring the experiences of people with complex regional pain syndrome. (22260304)
2012
12
Concurrent peripheral pathologies and complex regional pain syndrome type 1 as contributors to acute post-stroke shoulder pain: a case report. (22592581)
2012
13
A possible role of the locus coeruleus in complex regional pain syndrome. (23162445)
2012
14
Heart rate variability in complex regional pain syndrome during rest and mental and orthostatic stress. (22089824)
2012
15
Complex regional pain syndrome. (22022040)
2011
16
Complex regional pain syndrome type 1 in a child with migraine. (21572055)
2011
17
Advances in translational neuropathic research: example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome. (21360034)
2011
18
Autoimmunity against the I^2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. (21816540)
2011
19
Complex regional pain syndrome type I: disease or illness construction? Commentary on an article by Marlies I. Bodde, MD, et al.: "Therapy-resistant complex regional pain syndrome type I: to amputate or not?". (22005877)
2011
20
Clinical features and pathophysiology of complex regional pain syndrome. (21683929)
2011
21
Intramuscular botulinum toxin A (BtxA) in complex regional pain syndrome. (21587336)
2011
22
Is migraine a complex regional pain syndrome of the brain? Migraine prophylaxis with vitamin C? (21371256)
2011
23
Complex regional pain syndrome after musculoskeletal trauma: who owns the monkey? (20542152)
2010
24
Thermogram in spinal cord stimulation with complex regional pain syndrome and a review of the literature. (21992784)
2010
25
Different activation of opercular and posterior cingulate cortex (PCC) in patients with complex regional pain syndrome (CRPS I) compared with healthy controls during perception of electrically induced pain: a functional MRI study. (20393270)
2010
26
Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial. (20124231)
2010
27
Complex regional pain syndrome type I: neuropathic or not? (20461475)
2010
28
Use of calcitonin to prevent complex regional pain syndrome type I in severe hemiplegic patients after stroke. (19479511)
2009
29
Bilateral type 1 complex regional pain syndrome after local nerve blocks for palmar hyperhidrosis. (19389087)
2009
30
Corticobasal degeneration presenting as complex regional pain syndrome. (19224616)
2009
31
The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome. (19473768)
2009
32
Applying salve in complex regional pain syndrome. (21686618)
2009
33
Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review. (19573987)
2009
34
Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. (19604642)
2009
35
Inconsistency of response to conscious and unconscious motor imagery in complex regional pain syndrome: Comment on the article by Moseley et al. (19116957)
2009
36
Regulation of peripheral blood flow in complex regional pain syndrome: clinical implication for symptomatic relief and pain management. (19775468)
2009
37
Femoral neck stress fracture complicated by deep venous thrombosis and complex regional pain syndrome: a case report. (19627949)
2009
38
Spinal cord stimulation: "neural switch" in complex regional pain syndrome type I. (19638145)
2009
39
Increased plasma glutamate, glycine, and arginine levels in complex regional pain syndrome type 1. (18419723)
2008
40
Vasodilative effect of isosorbide dinitrate ointment in complex regional pain syndrome type 1. (18180642)
2008
41
Medical history and the onset of complex regional pain syndrome (CRPS). (18760877)
2008
42
Peripheral nerve vasculitis presenting as complex regional pain syndrome. (19169092)
2008
43
Six years follow-up of the levels of TNF-alpha and IL-6 in patients with complex regional pain syndrome type 1. (18596918)
2008
44
Effect of tadalafil on blood flow, pain, and function in chronic cold complex regional pain syndrome: a randomized controlled trial. (18937830)
2008
45
Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system. (16689997)
2006
46
Increased production of nitric oxide stimulated by interferon-gamma from peripheral blood monocytes in patients with complex regional pain syndrome. (11911993)
2002
47
Experiences with calcitonin treatment of patients with type I complex regional pain syndrome (CRPS I--Sudeck disease)]. (11605299)
2001
48
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. (10870738)
2000
49
Reflex sympathetic dystrophy, sympathetically maintained pain, and complex regional pain syndrome: diagnoses of inclusion, exclusion, or confusion? (11129251)
2000
50
Health-related quality of life in chronic refractory reflex sympathetic dystrophy (complex regional pain syndrome type I). (10946171)
2000

Genetic Variations for Complex Regional Pain Syndrome

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Expression for genes affiliated with Complex Regional Pain Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for genes affiliated with Complex Regional Pain Syndrome

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12EMD Millipore, 51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.2CALCA, TNF, IL6
210.2TACR1, TAC1
310.2TACR1, TAC1
4
Hide members
10.2ADRB2, ADRA1A, NPY
510.1CALCA, NPY, EDN1, ADRA1A
6
Hide members
10.1ADRB2, ADRA1A, IL6, EDN1
710.0TNF, IL6, TAC1, TACR1
8
Hide members
10.0CALCA, GABPA, IL6, ADRA1A, ADRB2
9
Hide members
9.9TACR1, TAC1, CXCR3, HCRT, NPY
10
Hide members
9.8NPS, EDN1, HCRT, TAC1, TACR1, ADRA1A
11
Hide members
9.3CALCA, NPS, NPY, EDN1, HCRT, CXCR3
12
Hide members
9.3ADRB2, CALCA, NPS, NPY, EDN1, HCRT

Compounds for genes affiliated with Complex Regional Pain Syndrome

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28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1methoxamine28 44 1112.5ADRA1A, NPY, EDN1
2helospectin4410.5NPY, CALCA, TAC1
3rp6758044 2811.5TAC1, TACR1, CALCA
4gr 7363244 5911.5CALCA, TACR1, TAC1
5estrogen4410.5TAC1, GCH1
6cromakalim44 2811.5CALCA, TAC1, EDN1
7resiniferatoxin44 2811.5CALCA, TAC1, TACR1
8groalpha4410.5TNF, CXCR3, CXCL9, IL6
9etanercept44 49 1112.5TNF, IL6, CXCR3, FCGR3A
10phenoxybenzamine44 1111.4NPY, ADRB2, TAC1, ADRA1A
11guanethidine44 1111.4TACR1, NPY, CALCA, TAC1
12il 104410.4TNF, IL6, CXCL9, CXCR3
13indomethacin44 59 28 1113.4CALCA, TAC1, NPY, TACR1
14ng-nitro-l-arginine4410.4CALCA, EDN1, TACR1, TAC1
15carbachol44 28 1112.4EDN1, HCRT, NPY, TAC1
16fenoterol44 28 1112.4TAC1, EDN1, ADRB2
17prostaglandin f2alpha4410.4ADRB2, TAC1, EDN1, NPY, CALCA
18phosphoramidon44 1111.4CALCA, TACR1, TAC1, EDN1, NPY
19ccl344 2811.3IL6, CXCL9, CXCR3, TNF
20thapsigargin44 5911.3TACR1, NPY, HCRT
21methacholine44 1111.3CALCA, TAC1, TACR1, ADRB2
22acetylcholine44 49 28 11 2414.3TACR1, TAC1, ADRB2, CALCA, HCRT
23l-nmma4410.3TACR1, TAC1, EDN1, TNF
24clonidine44 28 1112.3NPY, TAC1, CALCA, TACR1
25opiate4410.3HCRT, TAC1, TACR1, ADRB2, NPY
26tetrodotoxin44 59 2812.3CALCA, TAC1, TACR1, HCRT, EDN1, NPY
27isoproterenol44 1111.2TAC1, CALCA, NPY, EDN1, ADRB2
28sodium nitroprusside4410.2TACR1, TAC1, CXCL9, CXCR3, EDN1, NPY
29oxygen44 2411.2TNF, GABPA, INTS7, TACR1, ADRB2, FCGR3A
30adalimumab44 49 1112.2IL6, TNF, FCGR3A
31phentolamine28 44 1112.2NPY, TAC1, ADRA1A
32phenylephrine44 28 11 2413.2NPY, EDN1, HCRT, ADRA1A
33capsaicin44 2811.2NPY, CALCA, TACR1, TAC1
34creatinine4410.2NPY, EDN1, CXCR3, CXCL9, CALCA, IL6
355-hydroxytryptamine4410.2CALCA, HCRT, ADRB2, TACR1, TAC1, NPY
36atropine44 28 1112.2TAC1, NPY, CALCA, TACR1
37prostacyclin4410.1TAC1, TNF, TACR1, NPY, EDN1
38norepinephrine44 11 2412.1NPY, CALCA, GCH1, HCRT, TACR1, TAC1
39pge24410.1EDN1, TACR1, TAC1, IL6, CXCR3, TNF
40dopamine44 28 11 2413.0ADRA1A, ADRB2, TAC1, HCRT, NPY, CALCA
41dexamethasone44 49 28 1113.0IL6, TAC1, TACR1, CXCR3, HCRT, TNF
42arginine449.9ADRB2, NPY, GCH1, FCGR3A, TAC1, CXCL9
43thiorphan44 28 1111.9TAC1, CALCA, EDN1
44lactate449.9IL6, LPO, NPY, TNF, CALCA, ADRB2
45epinephrine44 11 2411.9HCRT, IL6, ADRA1A, LPO, EDN1, CALCA
46histamine44 28 2411.8TAC1, EDN1, HCRT, TACR1, CXCR3, IL6
47tyrosine449.7NPY, GCH1, FCGR3A, LPO, HCRT, CXCR3
48vegf449.7CXCR3, CXCL9, IL6, TNF, ADRB2, CALCA
49nitric oxide44 11 2411.5IL6, CXCL9, ADRB2, GCH1, NPY, CALCA
50calcium44 49 11 2412.4CXCL9, GCH1, CALCA, ADRA1A, FCGR3A, CXCR3

GO Terms for genes affiliated with Complex Regional Pain Syndrome

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16Gene Ontology
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Cellular components related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.0FCGR3A, IL6, CXCL9, CXCR3, TNF
2extracellular regionGO:0055769.3FCGR3A, CALCA, TNF, NPS, NPY, EDN1
3extracellular spaceGO:0056159.3CALCA, TNF, NPY, EDN1, LPO, CXCL9

Biological processes related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transmission of nerve impulseGO:05197110.6HCRT, IL6
2negative regulation of smooth muscle contractionGO:04598610.6CALCA, ADRB2
3positive regulation of nitric oxide biosynthetic processGO:04542910.5IL6, EDN1, TNF
4positive regulation of smooth muscle cell proliferationGO:04866110.5TNF, EDN1, IL6
5calcium-mediated signalingGO:01972210.5TNF, EDN1, CXCR3
6response to painGO:04826510.5TAC1, CALCA, GCH1
7detection of abiotic stimulusGO:00958210.5TACR1, TAC1
8positive regulation of saliva secretionGO:04687810.5TAC1, TACR1
9positive regulation of renal sodium excretionGO:03581510.5EDN1, TAC1, TACR1
10epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.5TNF, IL6
11response to heatGO:00940810.5TACR1, IL6, CALCA
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.5ADRA1A, TACR1, HCRT
13positive regulation of synaptic transmission, cholinergicGO:03222410.5TAC1, TACR1
14positive regulation of synaptic transmission, GABAergicGO:03223010.5NPS, TAC1, TACR1
15negative regulation of lipid storageGO:01088810.4TNF, IL6
16cell growthGO:01604910.4EDN1, IL6, ADRA1A
17positive regulation of lymphocyte proliferationGO:05067110.4TACR1, TAC1
18regulation of blood pressureGO:00821710.4TAC1, NPY, CALCA, GCH1
19response to lipopolysaccharideGO:03249610.4GCH1, EDN1, IL6, TAC1
20positive regulation of MAPK cascadeGO:04341010.4ADRB2, ADRA1A, IL6
21positive regulation of action potentialGO:04576010.4NPS, TAC1, TACR1, ADRA1A
22positive regulation of acute inflammatory responseGO:00267510.3IL6, TAC1
23neuropeptide signaling pathwayGO:00721810.3TAC1, HCRT, NPY, NPS, CALCA
24tachykinin receptor signaling pathwayGO:00721710.3TACR1, TAC1
25cell-cell signalingGO:00726710.3CALCA, EDN1, CXCL9, TAC1, ADRA1A
26positive regulation of hormone secretionGO:04688710.2TACR1, EDN1
27negative regulation of hormone secretionGO:04688810.2IL6, EDN1
28positive regulation of ERK1 and ERK2 cascadeGO:07037410.2ADRA1A, IL6, TNF
29elevation of cytosolic calcium ion concentrationGO:00720410.1ADRA1A, TACR1, TAC1, CXCR3, HCRT, EDN1
30inflammatory responseGO:00695410.1CALCA, TNF, CXCR3, CXCL9, IL6, TAC1
31agingGO:0075689.9CALCA, IL6, ADRA1A

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.1IL6, CXCL9, EDN1, TNF

Products for genes affiliated with Complex Regional Pain Syndrome

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Sources for Complex Regional Pain Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet