CRPS
MCID: CMP010
MIFTS: 63

Complex Regional Pain Syndrome (CRPS) malady

Rare diseases, Neuronal diseases categories
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Summaries for Complex Regional Pain Syndrome

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NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards based summary: Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to crohn's disease and migraine. An important gene associated with Complex Regional Pain Syndrome is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Pertussis. The compounds rantes and meclofenamate have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

NIH Rare Diseases:42 Complex regional pain syndrome (crps) is a chronic pain condition that mainly affects the arm or leg after an injury. the main feature of crps is continuous, intense pain that is out of proportion to the severity of the injury. the pain gets worse over time and often spreads throughout the entire affected arm or leg.  other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. the underlying cause of crps is not known. treatment aims to relieve pain and may include topical or oral medications; physical therapy; and/or a sympathetic nerve block. last updated: 10/19/2011

MedlinePlus:33 Complex regional pain syndrome (crps) is a chronic pain condition. it causes intense pain, usually in the arms, hands, legs, or feet. it may happen after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. symptoms in the affected area are dramatic changes in skin temperature, color, or texture intense burning pain extreme skin sensitivity swelling and stiffness in affected joints decreased ability to move the affected body part the cause of crps is unknown. there is no specific diagnostic test. your doctor will diagnose crps based on your signs and symptoms. there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. nih: national institute of neurological disorders and stroke

Wikipedia:65 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Description from OMIM:46 604335

Aliases & Classifications for Complex Regional Pain Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Complex Regional Pain Syndrome, Aliases & Descriptions:

Name: Complex Regional Pain Syndrome 8 42 43 10 48 46 33
Complex Regional Pain Syndromes 8 44 62
 
Reflex Sympathetic Dystrophy 42 62
Crps 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
complex regional pain syndrome:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:3223
MeSH34 D020918
OMIM46 604335
SNOMED-CT57 128200000
MESH via Orphanet35 D020918
ICD10 via Orphanet26 G56.4, M89.0
UMLS via Orphanet63 C0458219

Related Diseases for Complex Regional Pain Syndrome

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Diseases in the Complex Regional Pain Syndrome family:

Complex Regional Pain Syndrome Type 1

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 381)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease30.8TNF
2migraine30.7HCRT, CALCA
3pneumonia30.6IL6, TNF
4sepsis30.5TNF, IL6, CALCA
5periodontitis30.5IL6, TNF
6chorioamnionitis30.5TNF, IL6
7arthritis30.5TNF, IL6
8insulin resistance30.5TNF, IL6, EDN1
9systemic lupus erythematosus30.4TNF, CXCR3, IL6
10arteriosclerosis30.4EDN1
11obesity30.3IL6, TNF, HCRT
12psoriasis30.3IL6, CXCR3, TNF
13malaria30.3TNF
14atherosclerosis30.3IL6, CXCR3, TNF, EDN1
15peritonitis30.3TNF, IL6
16periodontal disease30.3IL6, TNF
17hepatitis c30.2CXCR3, TNF
18rheumatoid arthritis30.1CXCR3, TNF, IL6
19ulcerative colitis30.1IL6, TNF, CXCR3
20colitis30.0TNF, IL6
21uveitis30.0CXCR3, TNF
22juvenile rheumatoid arthritis29.9TNF, IL6
23synovitis29.9IL6, TNF
24diabetes mellitus29.8CALCA, IL6, TNF, EDN1
25chronic obstructive pulmonary disease29.7IL6, CXCR3, TNF
26osteoarthritis29.7CALCA, CXCR3, IL6, TNF
27asthma29.6TNF, EDN1, CXCR3
28complex regional pain syndrome type 111.2
29reflex sympathetic dystrophy11.0
30dystonia10.8
31causalgia10.7
32hemiplegia10.6
33blindness10.6
34cerebritis10.5
35periapical granuloma10.5CXCR3
36osteogenesis imperfecta10.5
37hepatorenal syndrome10.5EDN1
38skin disease10.4IL6
39burns10.4
40tetanus10.4
41fibromyalgia10.4
42myofascial pain syndrome10.4
43osteomalacia10.4
44pancoast tumor10.4
45dysautonomia10.4
46acute myocardial infarction10.3
47hypertension10.3
48myocardial infarction10.3
49artery disease10.3
50thoracic outlet syndrome10.3

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to complex regional pain syndrome

Symptoms for Complex Regional Pain Syndrome

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Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Complex Regional Pain Syndrome

Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

32
Skin, Spinal cord, Testes, Bone, Cortex, Brain, Heart, Monocytes, Cingulate cortex, Thalamus, Eye, Skeletal muscle, Lung, Endothelial, Pituitary

Animal Models for Complex Regional Pain Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6CXCR3, IL6, CALCA, EDN1
2MP:00020068.6TNF, CALCA, IL6, CXCR3
3MP:00053908.5IL6, TNF, EDN1, CALCA
4MP:00053887.9IL6, CALCA, HCRT, TNF, CXCR3
5MP:00053697.7SGCE, EDN1, HCRT, TNF, IL6
6MP:00053767.3CALCA, IL6, CXCR3, TNF, HCRT, EDN1
7MP:00053867.3CALCA, IL6, SGCE, TNF, HCRT
8MP:00036317.3TNF, SGCE, EDN1, IL6, CALCA, HCRT
9MP:00053856.9EDN1, HCRT, TNF, SGCE, CXCR3, IL6

Publications for Complex Regional Pain Syndrome

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Articles related to Complex Regional Pain Syndrome:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
The value of nerve blocks in the diagnoses and treatment of complex regional pain syndrome type 1: a series of 14 cases. (24953701)
2014
2
Use of a Medication Quantification Scale for Comparison of Pain Medication Usage in Patients with Complex Regional Pain Syndrome (CRPS). (25220567)
2014
3
Complex regional pain syndrome type I following tetanus toxoid injection. (24356477)
2014
4
The outcome of complex regional pain syndrome type 1: a systematic review. (24530407)
2014
5
Early adjunct treatment with topical lidocaine results in improved pain and function in a patient with complex regional pain syndrome. (25247913)
2014
6
Characteristics of Complex Regional Pain Syndrome in Patients Referred to a Tertiary Pain Clinic by Community Physicians, Assessed by the Budapest Clinical Diagnostic Criteria. (25339179)
2014
7
Immunoglobulin maintenance therapy in long-standing complex regional pain syndrome, an open study. (24023248)
2013
8
Concurrence of malignant peripheral nerve sheath tumor at the site of complex regional pain syndrome type 1 - a case report -. (23614078)
2013
9
Complex regional pain syndrome type I following discTRODE radiofrequency treated with continuous lumbar sympathetic trunk block using patient-controlled analgesia. (23294559)
2013
10
Relationships Between Psychological Factors, Pain and Disability in Complex Regional Pain Syndrome and Low Back Pain. (24135903)
2013
11
Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. (23267031)
2013
12
Complex regional pain syndrome following trigeminal nerve injury: report of 2 cases. (23643322)
2013
13
Type II complex regional pain syndrome of the hand resulting from repeated arterial punctures during transradial coronary intervention. (23378264)
2013
14
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system. (23291454)
2013
15
A case of recurrent complex regional pain syndrome accompanying Raynaud's disease: a prospective coincidence? (23720085)
2013
16
Is there a correlation between symptoms and bone scintigraphic findings in patients with complex regional pain syndrome? (22797817)
2012
17
Analysis of patterns of three-phase bone scintigraphy for patients with complex regional pain syndrome diagnosed using the proposed research criteria (the 'Budapest Criteria'). (22293544)
2012
18
Transitioning from a hospital rehabilitation programme to home: exploring the experiences of people with complex regional pain syndrome. (22260304)
2012
19
Effect of immunomodulating medications in complex regional pain syndrome: a systematic review. (22001668)
2012
20
Concordance of qualitative bone scintigraphy results with presence of clinical complex regional pain syndrome 1: meta-analysis of test accuracy studies. (22473897)
2012
21
Chinese scalp acupuncture relieves pain and restores function in complex regional pain syndrome. (23113454)
2012
22
Still's Disease and Recurrent Complex Regional Pain Syndrome Type-I: The First Description. (22162802)
2012
23
Successful reversal of complex regional pain syndrome type 1 of both upper extremities in five patients. (22776058)
2012
24
Concurrent peripheral pathologies and complex regional pain syndrome type 1 as contributors to acute post-stroke shoulder pain: a case report. (22592581)
2012
25
Complex regional pain syndrome. (21600455)
2011
26
MicroRNA modulation in complex regional pain syndrome. (22074333)
2011
27
Emotional and neuropsychological profiles of children with complex regional pain syndrome type-I in an inpatient rehabilitation setting. (20842016)
2011
28
Evidence based guidelines for complex regional pain syndrome type 1. (20356382)
2010
29
Migraine may be a risk factor for the development of complex regional pain syndrome. (19614690)
2010
30
Modifying diagnostic criteria for Complex Regional Pain Syndrome. (20483538)
2010
31
Plasticity of complex regional pain syndrome (CRPS) in children. (20704670)
2010
32
Botulinum toxin A (Botox) for treatment of proximal myofascial pain in complex regional pain syndrome: two cases. (20735753)
2010
33
Motor cortex dysfunction in complex regional pain syndrome. (20185362)
2010
34
Complex regional pain syndrome in the adolescent athlete. (19904065)
2009
35
Mirror therapy for chronic complex regional pain syndrome type 1 and stroke. (19657134)
2009
36
Effect of vitamin C on prevention of complex regional pain syndrome type I in foot and ankle surgery. (19840748)
2009
37
Complex regional pain syndrome type 1 may be associated with menstrual cycle disorders: a case-control study. (19942105)
2009
38
Rare case of autonomic instability of the lower limb presenting as painless Complex Regional Pain Syndrome type I following hip surgery: two case reports. (19830162)
2009
39
Conservative therapy for Complex Regional Pain Syndrome Type I in a paediatric patient: a case study. (19506699)
2009
40
Can the outcome of spinal cord stimulation in chronic complex regional pain syndrome type I patients be predicted by catastrophizing thoughts? (19608836)
2009
41
fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. (18567621)
2008
42
Psychological features of patients with complex regional pain syndrome type I related dystonia. (18546322)
2008
43
Tumor necrosis factor-alpha and interleukin-6 are not correlated with the characteristics of Complex Regional Pain Syndrome type 1 in 66 patients. (18055234)
2008
44
Using skin surface temperature to differentiate between complex regional pain syndrome type 1 patients after a fracture and control patients with various complaints after a fracture. (18165590)
2008
45
Correlation between changes in regional cerebral blood flow and pain relief in complex regional pain syndrome type 1. (16714887)
2006
46
Stress infrared telethermography is useful in the diagnosis of complex regional pain syndrome, Type I (formerly reflex sympathetic dystrophy). (17271895)
2004
47
Intravenous regional blocks with guanethidine and prilocaine combined with physiotherapy: two children with complex regional pain syndrome, type 1. (12095024)
2002
48
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. (10870738)
2000
49
Reflex sympathetic dystrophy, sympathetically maintained pain, and complex regional pain syndrome: diagnoses of inclusion, exclusion, or confusion? (11129251)
2000
50
Complex regional pain syndrome type I (RSD) or peripheral mononeuropathy? A discussion of three cases. (8776555)
1996

Variations for Complex Regional Pain Syndrome

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Expression for genes affiliated with Complex Regional Pain Syndrome

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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for genes affiliated with Complex Regional Pain Syndrome

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Pathways related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CALCA, EDN1
29.3TNF, IL6
39.3IL6, TNF
4
Show member pathways
IL27-mediated signaling events37
9.3IL6, TNF
59.3IL6, TNF
6
Show member pathways
thioredoxin pathway37
9.3IL6, TNF
7
Show member pathways
Immune response MIF in innate immunity response60
9.3IL6, TNF
8
Show member pathways
9.3TNF, IL6
99.3TNF, IL6
10
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3IL6, TNF
119.3TNF, IL6
129.3IL6, TNF
139.3IL6, TNF
149.3IL6, TNF
159.3IL6, TNF
169.3TNF, IL6
179.3TNF, IL6
189.0CALCA, IL6, TNF
19
Show member pathways
8.9TNF, CXCR3, IL6
20
Show member pathways
8.9TNF, CXCR3, IL6
218.9IL6, TNF, EDN1
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9EDN1, TNF, IL6
23
Show member pathways
8.5IL6, CXCR3, TNF, EDN1
24
Show member pathways
8.4EDN1, HCRT, CXCR3, CALCA
25
Show member pathways
8.4CALCA, CXCR3, HCRT, EDN1

Compounds for genes affiliated with Complex Regional Pain Syndrome

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Compounds related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1rantes4410.2CXCR3
2meclofenamate4410.0CALCA, EDN1
3cromakalim44 2811.0CALCA, EDN1
4thiorphan44 28 1111.8EDN1, CALCA
5mcp 1449.8IL6, CXCR3
6pamidronate44 50 1111.8IL6, CALCA
7n(g)-nitro-l-arginine methyl ester449.8CALCA, EDN1
8clodronate44 50 1111.8IL6, CALCA
9cicaprost44 2810.7EDN1, TNF
10tocilizumab44 1110.7TNF, IL6
11abatacept44 1110.7TNF, IL6
12cdp571449.7IL6, TNF
13tenidap44 2810.7TNF, IL6
14anakinra44 1110.7IL6, TNF
15taurine chloramine449.7IL6, TNF
16vesnarinone449.7TNF, IL6
17gabexate mesilate449.6IL6, TNF
18ulinastatin449.6TNF, IL6
19mip 1alpha449.6IL6, TNF
20pmma449.5CALCA, IL6
21il-12449.4IL6, TNF
22groalpha449.4CXCR3, IL6, TNF
23etanercept44 50 1111.4TNF, CXCR3, IL6
24il 10449.3IL6, CXCR3, TNF
25infliximab44 50 1111.3CXCR3, IL6, TNF
26ng-nitro-l-arginine449.3EDN1, CALCA
27ccl344 2810.3TNF, IL6, CXCR3
28adalimumab44 50 1111.3IL6, TNF
298-isoprostane449.3TNF, EDN1, IL6
30endotoxin449.3IL6, CXCR3, TNF
31atorvastatin44 50 28 24 1113.3EDN1, TNF, IL6
32tetrodotoxin44 61 2811.2CALCA, HCRT, EDN1
33herbimycin a44 6110.2EDN1, TNF, IL6
34calcitriol44 61 24 1112.2IL6, TNF, CALCA
355-hydroxytryptamine449.2HCRT, CALCA, EDN1
36creatinine449.1CALCA, IL6, CXCR3, EDN1
37acth449.0CALCA, IL6, HCRT
38hydrocortisone44 2 61 1112.0CXCR3, IL6, TNF, CALCA
39indomethacin44 28 61 1111.9EDN1, TNF, IL6, CALCA
40cyclosporin a44 28 6110.9IL6, EDN1, TNF, CALCA
41pd 98,059448.9IL6, CXCR3, TNF, EDN1
42thymidine44 249.9IL6, CXCR3, EDN1, TNF
43epinephrine44 24 1110.7IL6, CALCA, HCRT, EDN1
44norepinephrine44 24 1110.7IL6, HCRT, CALCA, EDN1
45pge2448.5CXCR3, EDN1, CALCA, IL6, TNF
46vegf448.5EDN1, TNF, CXCR3, IL6, CALCA
47dexamethasone44 50 28 1111.4HCRT, TNF, CXCR3, IL6
48estrogen448.3CALCA, IL6, CXCR3, HCRT
49histamine44 28 249.7HCRT, CALCA, IL6, CXCR3, TNF, EDN1
50nitric oxide44 24 119.7IL6, EDN1, TNF, CXCR3, CALCA, HCRT

GO Terms for genes affiliated with Complex Regional Pain Syndrome

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Cellular components related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6TNF, CXCR3, IL6
2extracellular regionGO:0055768.6IL6, HCRT, EDN1
3extracellular spaceGO:0056158.5CALCA, IL6, TNF, EDN1

Biological processes related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.0CALCA, EDN1
2monocyte chemotaxisGO:0025489.9CALCA, IL6
3negative regulation of hormone secretionGO:0468889.9EDN1, IL6
4response to heatGO:0094089.8IL6, CALCA
5response to amino acidGO:0432009.8IL6, EDN1
6cell growthGO:0160499.7IL6, EDN1
7positive regulation of JUN kinase activityGO:0435079.7TNF, EDN1
8positive regulation of mitosisGO:0458409.7EDN1, TNF
9negative regulation of lipid storageGO:0108889.7IL6, TNF
10epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7IL6, TNF
11positive regulation of chemokine productionGO:0327229.7TNF, IL6
12positive regulation of MAP kinase activityGO:0434069.6TNF, EDN1
13defense response to Gram-positive bacteriumGO:0508309.6IL6, TNF
14negative regulation of fat cell differentiationGO:0455999.6IL6, TNF
15positive regulation of interleukin-6 productionGO:0327559.6IL6, TNF
16positive regulation of peptidyl-serine phosphorylationGO:0331389.5IL6, TNF
17positive regulation of transmission of nerve impulseGO:0519719.5HCRT, IL6
18response to mechanical stimulusGO:0096129.5IL6, TNF
19protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.5EDN1, HCRT
20humoral immune responseGO:0069599.4IL6, TNF
21positive regulation of protein kinase B signalingGO:0518979.4IL6, TNF
22calcium-mediated signalingGO:0197229.4EDN1, TNF, CXCR3
23response to glucocorticoidGO:0513849.3TNF, IL6
24neuropeptide signaling pathwayGO:0072189.3CALCA, HCRT
25positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, TNF, EDN1
26positive regulation of cell proliferationGO:0082849.3EDN1, CXCR3, IL6
27positive regulation of smooth muscle cell proliferationGO:0486619.3IL6, TNF, EDN1
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2IL6, TNF
29positive regulation of ERK1 and ERK2 cascadeGO:0703749.0IL6, TNF
30inflammatory responseGO:0069548.9CALCA, IL6, CXCR3, TNF
31positive regulation of cytosolic calcium ion concentrationGO:0072048.8CALCA, CXCR3, HCRT, EDN1

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CALCA, EDN1
2cytokine activityGO:0051258.6IL6, TNF, EDN1

Products for genes affiliated with Complex Regional Pain Syndrome

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Sources for Complex Regional Pain Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet