Complex Regional Pain Syndrome (CRPS) malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Complex Regional Pain Syndrome

Aliases & Descriptions for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 50 51 41 14
Complex Regional Pain Syndromes 12 52 42 69
Reflex Sympathetic Dystrophy 50 69
Crps 50


External Ids:

Disease Ontology 12 DOID:3223
MeSH 42 D020918
SNOMED-CT 64 128200000
UMLS 69 C0458219

Summaries for Complex Regional Pain Syndrome

NIH Rare Diseases : 50 complex regional pain syndrome (crps) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. crps symptoms often begin after surgery or an injury. the main feature of crps is continuous, intense pain that is out of proportion to the severity of the injury. the pain gets worse over time and often spreads throughout the entire affected area. other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. the underlying cause of crps is often not known. two classifications of crps have been recognized based on causalgia. type i (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and type ii, in which peripheral nerve injury is present. treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy; and/or a sympathetic nerve block. last updated: 1/9/2017

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to burns and neuropathy, and has symptoms including back pain, headache and neuralgia. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Bupivacaine and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes.

MedlinePlus : 41 complex regional pain syndrome (crps) is a chronic pain condition. it causes intense pain, usually in the arms, hands, legs, or feet. it may happen after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. symptoms in the affected area are dramatic changes in skin temperature, color, or texture intense burning pain extreme skin sensitivity swelling and stiffness in affected joints decreased ability to move the affected body part the cause of crps is unknown. there is no specific diagnostic test. your doctor will diagnose crps based on your signs and symptoms. there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. nih: national institute of neurological disorders and stroke

NINDS : 51 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

Wikipedia : 71 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a long term... more...

Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 278)
id Related Disease Score Top Affiliating Genes
1 burns 30.1 IL10 IL6 TNF
2 neuropathy 29.9 IL1B IL6 TNF
3 hepatitis 29.3 HLA-A HLA-B IL10 IL6 TNF
4 choroiditis 29.2 CCL2 IL10 IL1B IL6 TNF
5 reflex sympathetic dystrophy 12.0
6 causalgia 11.9
7 thoracic outlet syndrome 11.1
8 autonomic nervous system disease 10.8
9 algoneurodystrophy 10.8
10 peripheral nervous system disease 10.8
11 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
12 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
13 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
14 intussusception 10.3 IL1B TNF
15 dyslexia 5 10.3 IL6 TNF
16 lagophthalmos 10.3 IL10 TNF
17 aortic atherosclerosis 10.3 IL6 TNF
18 oculomotor nerve paralysis 10.3 IL1B IL6
19 degenerative disc disease 10.3 IL6 TNF
20 common peroneal nerve lesion 10.3 IL1B IL6
21 tau syndrome 10.3 IL1B TNF
22 transient tic disorder 10.3 IL10 IL6 TNF
23 swine influenza 10.2 HLA-B IL6 TNF
24 trichomalacia 10.2 IL10 IL6 TNF
25 phlyctenulosis 10.2 IL10 IL6 TNF
26 conduct disorder 10.2 IL10 IL6 TNF
27 gastric dilatation 10.2 IL10 IL6 TNF
28 pancreatic signet ring cell adenocarcinoma 10.2 IL10 IL6 TNF
29 primary ciliary dyskinesia 10.2 IL10 IL6 TNF
30 stocco dos santos syndrome 10.2 IL1B TNF
31 hereditary alpha tryptasemia syndrome 10.2 IL10 IL6 TNF
32 erb-duchenne and dejerine-klumpke palsies 10.2 IL10 IL6 TNF
33 ureter inverted papilloma 10.2 IL10 IL6
34 plummer's disease 10.2 IL10 IL6 TNF
35 solid pseudopapillary carcinoma of pancreas 10.2 HLA-A HLA-B
36 myiasis 10.2 IL10 IL6 TNF
37 alcoholic hepatitis 10.2 IL10 IL6 TNF
38 mansonelliasis 10.2 IL10 IL6 TNF
39 cartilage disease 10.2 CALCA TAC1
40 anal paget's disease 10.2 IL1B IL6 TNF
41 bipolar i disorder 10.2 IL1B IL6 TNF
42 human immunodeficiency virus infectious disease 10.2 IL1B IL6 TNF
43 dystonia 10.2
44 measles 10.2 IL1B IL6 TNF
45 immunodeficiency by defective expression of hla class 1 10.2 CALCA IL6
46 dextrocardia 10.2 IL1B IL6 TNF
47 mirizzi syndrome 10.2 HLA-B TNF
48 multiple vertebral anomalies unusual facies 10.2 IL10 TNF
49 mikulicz disease 10.2 IL1B IL6 TNF
50 cryptococcosis 10.2 HLA-B IL10 TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:

Diseases related to Complex Regional Pain Syndrome

Symptoms & Phenotypes for Complex Regional Pain Syndrome

UMLS symptoms related to Complex Regional Pain Syndrome:

back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 231)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Acetaminophen Approved Phase 4 103-90-2 1983
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
9 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
12 Trace Elements Phase 4,Phase 3
13 Anesthetics Phase 4,Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
15 Anesthetics, Local Phase 4,Phase 3
16 Vitamins Phase 4,Phase 3
17 Protective Agents Phase 4,Phase 3
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2
19 Micronutrients Phase 4,Phase 3
20 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
21 Antioxidants Phase 4,Phase 3
22 Calcium, Dietary Phase 4,Phase 3,Phase 2
23 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
24 Calcitonin Gene-Related Peptide Phase 4
25 calcitonin Phase 4
26 calcium channel blockers Phase 4,Phase 2
27 Adjuvants, Anesthesia Phase 4,Phase 3
28 Narcotics Phase 4,Phase 3
29 GABA Agents Phase 4
30 Sodium Channel Blockers Phase 4
31 Analgesics, Opioid Phase 4,Phase 3
32 Tranquilizing Agents Phase 4,Phase 3,Phase 2
33 Diuretics, Potassium Sparing Phase 4
34 Anesthetics, General Phase 4,Phase 3,Phase 2
35 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
36 Vasodilator Agents Phase 4,Phase 2
37 Anti-Anxiety Agents Phase 4,Phase 2
38 Anti-Arrhythmia Agents Phase 4,Phase 2
gamma-Aminobutyric Acid Phase 4 56-12-2 119
40 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
41 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
42 Anticonvulsants Phase 4,Phase 2
43 Antimanic Agents Phase 4
44 Antipyretics Phase 4
45 Antiparkinson Agents Phase 4
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
Zoledronic acid Approved Phase 3,Phase 2 118072-93-8 68740
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
Menthol Approved Phase 3 2216-51-5 16666

Interventional clinical trials:

(show top 50) (show all 114)
id Name Status NCT ID Phase
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4
4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4
6 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4
7 Study on Impact of Fentanyl Matrix on Improvement of Pain and Functioning in Spinal Disorder-related Pain Completed NCT00797017 Phase 4
8 A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Completed NCT00642837 Phase 4
9 Autonomic Dysfunction and Spinal Cord Stimulation in Complex Regional Pain Syndrome Terminated NCT00780390 Phase 4
10 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
11 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
12 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
13 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
14 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
15 Bivalirudin Plus Stenting in Long Lesion to Avoid Periprocedural Myocardial Necrosis Trial Unknown status NCT01555658 Phase 3
16 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
17 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3
18 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3
19 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3
20 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3
21 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3
22 Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed NCT00516503 Phase 3
23 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3
24 Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT02972359 Phase 3
25 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Recruiting NCT02504008 Phase 3
26 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Recruiting NCT02883049 Phase 3
27 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
28 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2
29 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2
30 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
31 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2
32 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2
33 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2
34 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2
35 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2
36 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2
37 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2
38 An Efficacy Study of 2',3'-Dideoxyinosine (ddI) (BMY-40900) Administered Orally Twice Daily to Zidovudine Intolerant Patients With AIDS or AIDS-Related Complex Completed NCT00000672 Phase 2
39 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
40 Influence of Manual Therapy in Temporomandibular Joint Disorder Recruiting NCT02880774 Phase 1, Phase 2
41 Research Examining Gulf War Illness in Our Nations Service Members Recruiting NCT01846182 Phase 2
42 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2
43 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2
44 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2
45 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2
46 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2
47 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Recruiting NCT02321566 Phase 1
48 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329
49 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129
50 Structural and Functional Nerve Changes Following Immobilisation After Distal Radius Fracture - a Pilot Study (NRP) Unknown status NCT02396277

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :

Cochrane evidence based reviews: complex regional pain syndromes

Genetic Tests for Complex Regional Pain Syndrome

Anatomical Context for Complex Regional Pain Syndrome

MalaCards organs/tissues related to Complex Regional Pain Syndrome:

Skin, Spinal Cord, Testes, Bone, Cortex, Brain, Cingulate Cortex

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 737)
id Title Authors Year
[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study. ( 28072713 )
Is the Pain Medicine Community Reluctant to Discuss Limb Amputation in Patients with Intractable Complex Regional Pain Syndrome? ( 28082526 )
High Frequency Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Report. ( 28072810 )
Ultrasound-guided pulsed radiofrequency treatment of the cervical sympathetic chain for complex regional pain syndrome: A retrospective observational study. ( 28072749 )
Complex regional pain syndrome: medical and legal ramifications of clinical variability and experience and perspective of a practicing clinician. ( 28031726 )
Abdominal wall Type-I complex regional pain syndrome treated effectively with peripheral nerve field stimulation: a case report. ( 28044002 )
The Use of Transdermal Buprenorphine in Complex Regional Pain Syndrome: A Report of Two Cases. ( 27172230 )
Complex regional pain syndrome. ( 27491326 )
Pregabalin-Associated Stuttering in a Patient With Complex Regional Pain Syndrome: A Case Report. ( 27755156 )
Pediatric complex regional pain syndrome: a review. ( 27130211 )
Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Study of a Pregnant Female. ( 27008306 )
Adult Complex Regional Pain Syndrome Type I: A Narrative Review. ( 27890578 )
Complex regional pain syndrome in children: incidence and clinical characteristics. ( 27005945 )
Is poststroke complex regional pain syndrome the combination of shoulder pain and soft tissue injury of the wrist?: A prospective observational study: STROBE of ultrasonographic findings in complex regional pain syndrome. ( 27495051 )
Microvascular response in patients with complex regional pain syndrome as measured by laser Doppler imaging. ( 27113962 )
The effectiveness of transcutaneous electrical nerve stimulation in the management of patients with complex regional pain syndrome: A randomized, double-blinded, placebo-controlled prospective study. ( 26922847 )
Recovery From Osteoporosis in a Patient With Complex Regional Pain Syndrome Type 1. ( 26913843 )
Physiotherapy and the management of complex regional pain syndrome. ( 27641723 )
Venipuncture Induced Complex Regional Pain Syndrome Presenting as Inflammatory Arthritis. ( 27891152 )
Early Treatment of Acute Complex Regional Pain Syndrome after Fracture or Injury with Prednisone: Why Is There a Failure to Treat? A Case Series. ( 27445622 )
Complex regional pain syndrome type 1: Analysis of 108 patients. ( 27132482 )
Analysis of Common Single Nucleotide Polymorphisms in Complex Regional Pain Syndrome: Genome Wide Association Study Approach and Pooled DNA Strategy. ( 28025368 )
Incidence of Complex Regional Pain Syndrome I Following Foot and Ankle Fractures Using the Budapest Criteria. ( 27064105 )
Long-term Prednisolone in Post-stroke Complex Regional Pain Syndrome. ( 27906935 )
Complex Regional Pain Syndrome. ( 27518298 )
Complex regional pain syndrome type I in children: What is new? ( 27979741 )
Ultrasound-Guided Continuous Superficial Radial Nerve Block for Complex Regional Pain Syndrome. ( 27159548 )
Pulsed radiofrequency applied to the dorsal root ganglia for treatment of post-stroke complex regional pain syndrome: A case series. ( 27555163 )
Complex regional pain syndrome: Measurement matters: Re: Galve-Villa M, Rittig-Rasmussen B, Mikkelsen LMS, Poulsen AG. Complex Regional Pain Syndrome. Manual Therapy 2016; accepted manuscript in press. ( 27527554 )
Is the brain of complex regional pain syndrome patients truly different? ( 27161331 )
Effects of Mirror Therapy in Stroke Patients With Complex Regional Pain Syndrome Type 1: A Randomized Controlled Study. ( 26723854 )
Complex Regional Pain Syndrome of the Breast and Chest Wall. ( 26945823 )
Complex Regional Pain Syndrome-Type 1 Presenting as deQuervain's Stenosing Tenosynovitis. ( 26752490 )
Focus on the bone in complex regional pain syndrome type I. ( 27010840 )
Complex regional pain syndrome associated with hyperattention rather than neglect for the healthy side: A comprehensive case study. ( 27887906 )
Reply to Letter to the Editor: 'Complex regional pain syndrome: Measurement matters'. ( 27615404 )
Phenotypic Variation in Complex Regional Pain Syndrome: Comparison Between Presentation in Knee Alone or in Ankle/Foot. ( 28025367 )
Complex regional pain syndrome (CRPS): evidence for warm and cold subtypes in a large prospective clinical sample. ( 27023422 )
Continuous Thoracic Sympathetic Ganglion Block in Complex Regional Pain Syndrome Patients with Spinal Cord Stimulation Implantation. ( 27445617 )
'Pseudofailure' of spinal cord stimulation for neuropathic pain following a new severe noxious stimulus: learning points from a case series of failed spinal cord stimulation for complex regional pain syndrome and failed back surgery syndrome. ( 27551417 )
Complex regional pain syndrome after transfemoral coronary balloon angioplasty. ( 28045417 )
Predictors of Responsiveness to Bisphosphonate Treatment in Patients with Complex Regional Pain Syndrome Type I: A Retrospective Chart Analysis. ( 27651505 )
Case study: Gluteal compartment syndrome as a cause of lumbosacral radiculoplexopathy and complex regional pain syndrome. ( 27533628 )
Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease. ( 27454281 )
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. ( 27651875 )
Predictors of long term outcome of thoracic sympathectomy in complex regional pain syndrome (CRPS) type 2. ( 27155377 )
Bisphosphonates Inhibit Pain, Bone Loss, and Inflammation in a Rat Tibia Fracture Model of Complex Regional Pain Syndrome. ( 27636578 )
Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome. ( 26940669 )
Management of patients with complex regional pain syndrome type I. ( 26928187 )
Amputation in patients with complex regional pain syndrome: a comparative study between amputees and non-amputees with intractable disease. ( 27037439 )

Variations for Complex Regional Pain Syndrome

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 46)
id Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.93 CCL2 EDN1 IL1B IL6 TNF
Show member pathways
12.86 CCL2 IL10 IL1B IL6 TNF
Show member pathways
Show member pathways
Show member pathways
12.56 CCL2 IL10 IL1B IL6 TNF
Show member pathways
12.53 IL10 IL1B IL6 TNF
8 12.48 CCL2 IL10 IL1B TNF
Show member pathways
12.39 IL10 IL1B IL6 TNF
10 12.38 HLA-A HLA-B IL6 TNF
Show member pathways
12.3 CCL2 IL1B IL6 TNF
Show member pathways
12.3 CCL2 IL1B IL6 TNF
13 12.2 IL10 IL1B IL6 TNF
14 12.13 IL10 IL1B IL6 TAC1 TNF
15 12.08 CCL2 EDN1 IL1B TNF
16 12 CCL2 IL1B IL6 TNF
17 11.98 IL10 IL6 MME TNF
Show member pathways
11.94 IL10 IL1B IL6 TNF
19 11.91 CCL2 IL10 IL1B IL6 TNF
20 11.89 IL1B IL6 MME TNF
21 11.87 IL10 IL1B IL6 TNF
22 11.86 CCL2 EDN1 IL1B IL6 TNF
23 11.83 CCL2 IL1B IL6 TNF
24 11.76 IL10 IL1B TNF
25 11.76 CCL2 EDN1 IL1B IL6 TNF
26 11.73 IL10 IL1B IL6 TNF
27 11.69 IL10 IL6 TNF
Show member pathways
11.64 IL1B IL6 TNF
Show member pathways
30 11.6 IL10 IL1B IL6 MME TNF
31 11.57 IL1B IL6 TNF
32 11.51 CCL2 IL1B TNF
33 11.46 CALCA IL1B IL6 TNF
34 11.35 CALCA EDN1 NPY
35 11.34 IL10 IL1B IL6 TNF
36 11.34 CCL2 IL10 IL1B IL6 TNF
37 11.32 IL10 IL1B IL6 TNF
38 11.31 IL1B IL6 TNF
39 11.29 IL1B IL6 TNF
40 11.24 CCL2 IL10 IL1B IL6 TNF
41 11.18 IL10 IL1B IL6 TNF
42 11.16 CCL2 IL10 IL1B IL6 TNF
43 10.98 IL6 TNF
44 10.94 CCL2 IL1B TNF
46 10.87 IL1B IL6

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA CCL2 EDN1 IL10 IL1B IL6
2 extracellular space GO:0005615 9.28 CALCA CCL2 EDN1 IL10 IL1B IL6
3 MHC class I protein complex GO:0042612 9.16 HLA-A HLA-B

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.91 CALCA CCL2 IL10 IL6
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.9 CALCA EDN1 TAC1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TNF
4 neuron projection development GO:0031175 9.9 IL6 NPY TOR1A
5 cell-cell signaling GO:0007267 9.89 CALCA EDN1 IL10 IL1B TAC1
6 neuropeptide signaling pathway GO:0007218 9.87 CALCA NPY TAC1
7 cellular response to interleukin-1 GO:0071347 9.85 CCL2 EDN1 IL6
8 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 IL1B TNF
9 cellular response to drug GO:0035690 9.84 CCL2 EDN1 IL1B
10 neutrophil chemotaxis GO:0030593 9.83 CCL2 EDN1 IL1B
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 EDN1 IL6 TNF
12 humoral immune response GO:0006959 9.82 CCL2 IL6 TNF
13 sensory perception of pain GO:0019233 9.81 EDN1 MME TAC1
14 cellular response to lipopolysaccharide GO:0071222 9.81 CCL2 IL10 IL6 TNF
15 immune response GO:0006955 9.8 CCL2 HLA-A HLA-B IL10 IL1B IL6
16 response to heat GO:0009408 9.79 CALCA CCL2 IL6
17 response to activity GO:0014823 9.78 CCL2 EDN1 IL10
18 cellular response to tumor necrosis factor GO:0071356 9.78 CALCA CCL2 EDN1 IL6
19 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL6 TNF
20 monocyte chemotaxis GO:0002548 9.76 CALCA CCL2 IL6
21 response to pain GO:0048265 9.73 CALCA TAC1
22 defense response to protozoan GO:0042832 9.73 IL10 IL6
23 cellular response to estradiol stimulus GO:0071392 9.73 CCL2 IL10 IL6
24 response to glucocorticoid GO:0051384 9.73 CCL2 IL10 IL6 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
26 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.72 IL10 TNF
27 positive regulation of chemokine production GO:0032722 9.72 IL6 TNF
28 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
29 response to amino acid GO:0043200 9.72 CCL2 EDN1 IL6
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
31 positive regulation of ossification GO:0045778 9.71 CALCA TAC1
32 cellular response to hepatocyte growth factor stimulus GO:0035729 9.71 IL10 IL6
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
34 positive regulation of renal sodium excretion GO:0035815 9.71 EDN1 TAC1
35 protein kinase B signaling GO:0043491 9.71 CCL2 IL1B TNF
36 regulation of blood pressure GO:0008217 9.71 CALCA EDN1 NPY TAC1
37 negative regulation of bone resorption GO:0045779 9.7 CALCA IL6
38 negative regulation of hormone secretion GO:0046888 9.7 EDN1 IL6
39 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 CCL2 IL1B TNF
40 maternal process involved in parturition GO:0060137 9.69 CCL2 EDN1
41 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
42 positive regulation of acute inflammatory response GO:0002675 9.69 IL6 TAC1
43 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
44 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.68 HLA-A HLA-B
45 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
46 positive regulation of prostaglandin secretion GO:0032308 9.67 EDN1 IL1B
47 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
49 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF
50 regulation of vascular endothelial growth factor production GO:0010574 9.63 CCL2 IL6

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CCL2 EDN1 IL10 IL1B IL6 TNF
2 hormone activity GO:0005179 9.33 CALCA EDN1 NPY
3 receptor binding GO:0005102 9.17 CALCA CCL2 EDN1 HLA-A HLA-B IL6

Sources for Complex Regional Pain Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
65 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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