Complex Regional Pain Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Complex Regional Pain Syndrome

MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 50 51 41 14
Complex Regional Pain Syndromes 12 52 42 69
Reflex Sympathetic Dystrophy 50 69
Crps 50


External Ids:

Disease Ontology 12 DOID:3223
MeSH 42 D020918
SNOMED-CT 64 128200000
UMLS 69 C0458219

Summaries for Complex Regional Pain Syndrome

NIH Rare Diseases : 50 complex regional pain syndrome (crps) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. crps symptoms often begin after surgery or an injury. the main feature of crps is continuous, intense pain that is out of proportion to the severity of the injury. the pain gets worse over time and often spreads throughout the entire affected area. other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. the underlying cause of crps is often not known. two classifications of crps have been recognized based on causalgia. type i (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and type ii, in which peripheral nerve injury is present. treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy; and/or a sympathetic nerve block. last updated: 1/9/2017

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to causalgia and tetanus, and has symptoms including back pain, headache and neuralgia. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes, and related phenotype is integument.

MedlinePlus : 41 complex regional pain syndrome (crps) is a chronic pain condition. it causes intense pain, usually in the arms, hands, legs, or feet. it may happen after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. symptoms in the affected area are dramatic changes in skin temperature, color, or texture intense burning pain extreme skin sensitivity swelling and stiffness in affected joints decreased ability to move the affected body part the cause of crps is unknown. there is no specific diagnostic test. your doctor will diagnose crps based on your signs and symptoms. there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. nih: national institute of neurological disorders and stroke

NINDS : 51 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

Wikipedia : 72 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a long term... more...

Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
id Related Disease Score Top Affiliating Genes
1 causalgia 32.7 CCL2 IL10 IL1B TNF
2 tetanus 30.5 CALCA TNF
3 somatoform disorder 30.3 CALCA TAC1
4 hypertrichosis 30.2 IL1B IL6 TNF
5 alopecia 29.5 CCL2 IL10 IL6 TNF
6 choroiditis 28.9 CCL2 IL10 IL1B IL6 TNF
7 reflex sympathetic dystrophy 11.9
8 thoracic outlet syndrome 11.1
9 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
10 aortic arch interruption 10.8 IL6 TNF
11 pure autonomic failure 10.8 IL10 TNF
12 cutaneous leishmaniasis 10.8 IL6 TNF
13 autonomic nervous system disease 10.8
14 algoneurodystrophy 10.8
15 peripheral nervous system disease 10.8
16 acute ackee fruit intoxication 10.8 IL10 TNF
17 isolated scaphocephaly 10.8 CALCA IL6
18 spirillary rat-bite fever 10.8 IL6 TNF
19 toxoplasmosis 10.7 IL6 TNF
20 peroneal nerve paralysis 10.7 IL10 IL6
21 multiple familial trichoepithelioma 10.7 IL10 TNF
22 basidiobolomycosis 10.7 IL10 TNF
23 lagophthalmos 10.7 IL10 TNF
24 dyslexia 5 10.7 IL6 TNF
25 drug rash with eosinophilia and systemic symptoms 10.7 IL10 IL6
26 low compliance bladder 10.7 CALCA TNF
27 migraine with brainstem aura 10.7 HLA-B TNF
28 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
29 epstein-barr virus hepatitis 10.7 IL6 TNF
30 anencephaly and spina bifida x-linked 10.7 IL6 TNF
31 oculomotor nerve paralysis 10.7 IL1B IL6
32 endosalpingiosis 10.7 IL10 TNF
33 common peroneal nerve lesion 10.7 IL1B IL6
34 cartilage disease 10.7 CALCA TAC1
35 tabatznik syndrome 10.7 IL1B TNF
36 sternal cleft 10.7 IL1B TNF
37 papilledema 10.6 IL6 TNF
38 idiopathic dilatation of the pulmonary artery 10.6 IL10 TNF
39 pulmonary hypertension 10.6 IL1B TNF
40 walker dyson syndrome 10.6 IL1B TNF
41 liver leiomyoma 10.6 IL10 TNF
42 tarsal tunnel syndrome 10.6 IL10 TNF
43 juvenile dermatitis herpetiformis 10.6 CALCA IL6
44 ethmoid sinus adenocarcinoma 10.6 IL10 IL6 TNF
45 tricho onychic dysplasia 10.6 IL10 IL6 TNF
46 phlyctenulosis 10.6 IL10 IL6 TNF
47 primary biliary cirrhosis 10.6 IL10 IL6 TNF
48 hepadnavirus infection 10.6 IL10 IL6 TNF
49 cataract 10.6 IL1B TNF
50 ulcerative colitis 10.6 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:

Diseases related to Complex Regional Pain Syndrome

Symptoms & Phenotypes for Complex Regional Pain Syndrome

UMLS symptoms related to Complex Regional Pain Syndrome:

back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 IL10 IL1B IL6 MME SCN9A TAC1

Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
Acetaminophen Approved Phase 4 103-90-2 1983
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
11 Antioxidants Phase 4,Phase 3
12 Micronutrients Phase 4,Phase 3
13 Protective Agents Phase 4,Phase 3
14 Trace Elements Phase 4,Phase 3
15 Vitamins Phase 4,Phase 3
16 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
17 Anesthetics Phase 4,Phase 3,Phase 2
18 Anesthetics, Local Phase 4,Phase 3
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
20 Neurotransmitter Agents Phase 4,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
22 Psychotropic Drugs Phase 4,Phase 2
23 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
25 triamcinolone acetonide Phase 4,Phase 3
26 Triamcinolone diacetate Phase 4,Phase 3
27 Triamcinolone hexacetonide Phase 4,Phase 3
28 Anti-Anxiety Agents Phase 4,Phase 2
29 Anti-Arrhythmia Agents Phase 4,Phase 2
30 Anticonvulsants Phase 4,Phase 2
31 Antimanic Agents Phase 4
32 Antiparkinson Agents Phase 4
33 calcium channel blockers Phase 4,Phase 2
34 Calcium, Dietary Phase 4,Phase 3,Phase 2
35 Diuretics, Potassium Sparing Phase 4
36 Excitatory Amino Acid Antagonists Phase 4,Phase 2
37 Excitatory Amino Acids Phase 4,Phase 2
38 GABA Agents Phase 4
39 Sodium Channel Blockers Phase 4
40 Tranquilizing Agents Phase 4,Phase 2
41 calcitonin Phase 4
42 Calcitonin Gene-Related Peptide Phase 4
43 Vasodilator Agents Phase 4,Phase 2
44 Adjuvants, Anesthesia Phase 4,Phase 3
45 Analgesics, Opioid Phase 4,Phase 3
46 Anesthetics, General Phase 4,Phase 3,Phase 2
47 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
48 Narcotics Phase 4,Phase 3
49 Antipyretics Phase 4
Ropivacaine Approved Phase 3 84057-95-4 71273 175805

Interventional clinical trials:

(show top 50) (show all 115)

id Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
6 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
7 Study on Impact of Fentanyl Matrix on Improvement of Pain and Functioning in Spinal Disorder-related Pain Completed NCT00797017 Phase 4 fentanyl;fentanyl;fentanyl;fentanyl;fentanyl;fentanyl;fentanyl
8 A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Completed NCT00642837 Phase 4 Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen
9 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Not yet recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
10 Autonomic Dysfunction and Spinal Cord Stimulation in Complex Regional Pain Syndrome Terminated NCT00780390 Phase 4
11 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
12 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
13 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
14 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
15 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
16 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
17 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
18 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
19 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
20 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
21 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
22 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
23 Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT02972359 Phase 3 Neridronic acid
24 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
25 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
26 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
27 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
28 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
29 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
30 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
31 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
32 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
33 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
34 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Cannabis;Cannabis;Cannabis
35 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
36 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
37 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
38 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
39 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
40 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
41 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
42 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Recruiting NCT02321566 Phase 1
43 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329
44 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 placebo
45 Structural and Functional Nerve Changes Following Immobilisation After Distal Radius Fracture - a Pilot Study (NRP) Unknown status NCT02396277
46 Multi-disciplinary Prevention Program Unknown status NCT02563431
47 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783
48 Graded Exposure (GEXP) in Vivo Versus Physiotherapy in Complex Regional Pain Syndrome Type I (CRPS-I) Completed NCT00625976
49 Near-infrared Spectroscopic Measurement in Complex Regional Pain Syndrome Completed NCT01586377
50 Evaluation of the Physiodoloris Pain Monitor in Patients With Complex Regional Pain Syndrome Completed NCT02663284 Ropivacaine 0.5%

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :

Cochrane evidence based reviews: complex regional pain syndromes

Genetic Tests for Complex Regional Pain Syndrome

Anatomical Context for Complex Regional Pain Syndrome

MalaCards organs/tissues related to Complex Regional Pain Syndrome:

Skin, Spinal Cord, Testes, Bone, Cortex, Dorsal Root Ganglion, Heart

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 760)
id Title Authors Year
Hand lesion after arthroscopic rotator cuff repair: Association with complex regional pain syndrome. ( 28947243 )
High Frequency Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Report. ( 28072810 )
Home training in sensorimotor discrimination reduces pain in complex regional pain syndrome (CRPS). ( 28850333 )
The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture. ( 28691512 )
Effects of Simvastatin Beyond Dyslipidemia: Exploring Its Antinociceptive Action in an Animal Model of Complex Regional Pain Syndrome-Type I. ( 28928655 )
Complex Regional Pain Syndrome (CRPS): High risk of CRPS after trauma in another limb in patients who already have CRPS in one hand or foot: Lasting changes in neural pain modulating systems? ( 28850440 )
Abdominal wall Type-I complex regional pain syndrome treated effectively with peripheral nerve field stimulation: a case report. ( 28044002 )
Three cases of type-1 complex regional pain syndrome after elective total hip replacement. ( 28862131 )
Pain, Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, RSD, CRPS) ( 28613470 )
Complex regional pain syndrome: medical and legal ramifications of clinical variability and experience and perspective of a practicing clinician. ( 28031726 )
Is the Pain Medicine Community Reluctant to Discuss Limb Amputation in Patients with Intractable Complex Regional Pain Syndrome? ( 28082526 )
Qualitative pain research emphasizes that patients need true information and physicians and nurses need more knowledge of complex regional pain syndrome (CRPS). ( 28850331 )
Sex differences in complex regional pain syndrome type I (CRPS-I) in mice. ( 28831269 )
Intrathecal management of complex regional pain syndrome: A case report and literature. ( 28850424 )
Molecular signature of complex regional pain syndrome (CRPS) and its analysis. ( 28803495 )
[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study. ( 28072713 )
Complex Regional Pain Syndrome Type I, a Debilitating and Poorly Understood Syndrome. Possible Role for Pulsed Electromagnetic Fields: A Narrative Review. ( 28934787 )
The risk of pain syndrome affecting a previously non-painful limb following trauma or surgery in patients with a history of complex regional pain syndrome. ( 28850441 )
Pain reduction due to novel sensory-motor training in Complex Regional Pain Syndrome I - A pilot study. ( 28850342 )
Ultrasound-guided pulsed radiofrequency treatment of the cervical sympathetic chain for complex regional pain syndrome: A retrospective observational study. ( 28072749 )
Biased visuospatial perception in complex regional pain syndrome. ( 28852115 )
Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis. ( 28774452 )
Different patterns in mental rotation of facial expressions in complex regional pain syndrome patients. ( 28953620 )
Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I). ( 28914784 )
Passive transfer autoimmunity in a mouse model of complex regional pain syndrome. ( 28891866 )
Complex Regional Pain Syndrome following an Episode of Herpes Zoster: A Case Report. ( 28819596 )
Reply to Letter to the Editor: 'Complex regional pain syndrome: Measurement matters'. ( 27615404 )
The Use of Transdermal Buprenorphine in Complex Regional Pain Syndrome: A Report of Two Cases. ( 27172230 )
Local anaesthetic sympathetic blockade for complex regional pain syndrome. ( 27467116 )
Incidence of Complex Regional Pain Syndrome I Following Foot and Ankle Fractures Using the Budapest Criteria. ( 27064105 )
Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease. ( 27454281 )
Complex regional pain syndrome type I in children: What is new? ( 27979741 )
Effects of Mirror Therapy in Stroke Patients With Complex Regional Pain Syndrome Type 1: A Randomized Controlled Study. ( 26723854 )
Complex Regional Pain Syndrome: What Is the Evidence? ( 28034971 )
Multicenter study on the asymmetry of skin temperature in complex regional pain syndrome: An examination of temperature distribution and symptom duration. ( 28033251 )
Complex Regional Pain Syndrome of the Breast and Chest Wall. ( 26945823 )
Adult Complex Regional Pain Syndrome Type I: A Narrative Review. ( 27890578 )
Bisphosphonates Inhibit Pain, Bone Loss, and Inflammation in a Rat Tibia Fracture Model of Complex Regional Pain Syndrome. ( 27636578 )
Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome. ( 26940669 )
Complex regional pain syndrome type 1: Analysis of 108 patients. ( 27132482 )
Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Study of a Pregnant Female. ( 27008306 )
Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome. ( 27919822 )
Predictors of long term outcome of thoracic sympathectomy in complex regional pain syndrome (CRPS) type 2. ( 27155377 )
Complex Regional Pain Syndrome-Type 1 Presenting as deQuervain's Stenosing Tenosynovitis. ( 26752490 )
Complex regional pain syndrome: Measurement matters: Re: Galve-Villa M, Rittig-Rasmussen B, Mikkelsen LMS, Poulsen AG. Complex Regional Pain Syndrome. Manual Therapy 2016; accepted manuscript in press. ( 27527554 )
Early Treatment of Acute Complex Regional Pain Syndrome after Fracture or Injury with Prednisone: Why Is There a Failure to Treat? A Case Series. ( 27445622 )
Novel Signs and their Clinical Utility in Diagnosing Complex Regional Pain Syndrome (CRPS) - A Prospective Observational Cohort Study. ( 27662180 )
Sensitization of the Nociceptive System in Complex Regional Pain Syndrome. ( 27149519 )
Management of patients with complex regional pain syndrome type I. ( 26928187 )
Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection. ( 27651875 )

Variations for Complex Regional Pain Syndrome

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 46)
id Super pathways Score Top Affiliating Genes
Show member pathways
13.28 CCL2 HLA-B IL10 IL1B IL6 TNF
Show member pathways
12.91 CCL2 EDN1 IL1B IL6 TNF
Show member pathways
12.82 CCL2 IL10 IL1B IL6 TNF
Show member pathways
12.8 HLA-B IL10 IL1B IL6 TNF
Show member pathways
Show member pathways
12.54 CCL2 IL10 IL1B IL6 TNF
Show member pathways
12.53 IL10 IL1B IL6 TNF
8 12.48 CCL2 IL10 IL1B TNF
Show member pathways
12.39 IL10 IL1B IL6 TNF
Show member pathways
12.29 CCL2 IL1B IL6 TNF
11 12.19 IL10 IL1B IL6 TNF
12 12.13 IL10 IL1B IL6 TAC1 TNF
Show member pathways
12.1 HLA-B IL10 IL1B IL6 TNF
14 12.07 CCL2 EDN1 IL1B TNF
15 11.99 CCL2 IL1B IL6 TNF
16 11.97 IL10 IL6 MME TNF
Show member pathways
11.92 IL10 IL1B IL6 TNF
18 11.89 CCL2 IL10 IL1B IL6 TNF
19 11.87 IL1B IL6 MME TNF
20 11.86 IL10 IL1B IL6 TNF
21 11.84 CCL2 EDN1 IL1B IL6 TNF
22 11.82 CCL2 IL1B IL6 TNF
23 11.75 IL10 IL1B TNF
24 11.73 IL10 IL1B IL6 TNF
25 11.72 CCL2 EDN1 IL1B IL6 TNF
26 11.69 IL10 IL6 TNF
Show member pathways
11.64 IL1B IL6 TNF
28 11.57 IL1B IL6 TNF
29 11.54 IL10 IL1B IL6 MME TNF
30 11.5 CCL2 IL1B TNF
31 11.46 CALCA IL1B IL6 TNF
32 11.34 CALCA EDN1 NPY
33 11.32 IL10 IL1B IL6 TNF
34 11.3 IL1B IL6 TNF
35 11.3 IL10 IL1B IL6 TNF
36 11.28 IL1B IL6 TNF
37 11.24 CCL2 IL10 IL1B IL6 TNF
38 11.16 CCL2 IL10 IL1B IL6 TNF
39 11.15 IL10 IL1B IL6 TNF
40 11.04 IL1B TNF
41 11.04 IL6 TNF
42 11.04 CCL2 IL10 IL1B IL6 TNF
43 10.97 IL6 TNF
44 10.94 CCL2 IL1B TNF
46 10.86 IL1B IL6

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA CCL2 EDN1 IL10 IL1B IL6
2 extracellular space GO:0005615 9.28 CALCA CCL2 EDN1 IL10 IL1B IL6

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.99 CCL2 EDN1 IL10 IL6
2 immune response GO:0006955 9.93 CCL2 HLA-B IL10 IL1B IL6 TNF
3 aging GO:0007568 9.91 CALCA CCL2 IL10 IL6
4 cytokine-mediated signaling pathway GO:0019221 9.9 CCL2 IL1B IL6
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.9 CALCA EDN1 TAC1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 TNF
7 cell-cell signaling GO:0007267 9.88 CALCA EDN1 IL10 IL1B TAC1
8 neuropeptide signaling pathway GO:0007218 9.87 CALCA NPY TAC1
9 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 IL1B TNF
10 cellular response to interleukin-1 GO:0071347 9.85 CCL2 EDN1 IL6
11 cellular response to drug GO:0035690 9.83 CCL2 EDN1 IL1B
12 neutrophil chemotaxis GO:0030593 9.83 CCL2 EDN1 IL1B
13 cellular response to lipopolysaccharide GO:0071222 9.83 CCL2 IL10 IL6 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 EDN1 IL6 TNF
15 humoral immune response GO:0006959 9.81 CCL2 IL6 TNF
16 cellular response to tumor necrosis factor GO:0071356 9.81 CALCA CCL2 EDN1 IL6
17 response to heat GO:0009408 9.8 CALCA CCL2 IL6
18 positive regulation of interleukin-6 production GO:0032755 9.79 IL1B IL6 TNF
19 response to activity GO:0014823 9.77 CCL2 EDN1 IL10
20 monocyte chemotaxis GO:0002548 9.77 CALCA CCL2 IL6
21 cellular response to estradiol stimulus GO:0071392 9.74 CCL2 IL10 IL6
22 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 IL10 TNF
23 defense response to protozoan GO:0042832 9.73 IL10 IL6
24 protein kinase B signaling GO:0043491 9.73 CCL2 IL1B TNF
25 response to glucocorticoid GO:0051384 9.73 CCL2 IL10 IL6 TNF
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.72 IL1B TNF
27 response to pain GO:0048265 9.72 CALCA TAC1
28 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
29 response to amino acid GO:0043200 9.72 CCL2 EDN1 IL6
30 positive regulation of chemokine production GO:0032722 9.71 IL6 TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
32 negative regulation of growth of symbiont in host GO:0044130 9.71 IL10 TNF
33 positive regulation of ossification GO:0045778 9.71 CALCA TAC1
34 cellular response to hepatocyte growth factor stimulus GO:0035729 9.71 IL10 IL6
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 IL1B TNF
36 regulation of blood pressure GO:0008217 9.71 CALCA EDN1 NPY TAC1
37 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
38 positive regulation of renal sodium excretion GO:0035815 9.7 EDN1 TAC1
39 negative regulation of bone resorption GO:0045779 9.7 CALCA IL6
40 positive regulation of acute inflammatory response GO:0002675 9.69 IL6 TAC1
41 negative regulation of hormone secretion GO:0046888 9.69 EDN1 IL6
42 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
43 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
44 maternal process involved in parturition GO:0060137 9.68 CCL2 EDN1
45 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
46 positive regulation of prostaglandin secretion GO:0032308 9.67 EDN1 IL1B
47 positive regulation of interleukin-8 production GO:0032757 9.67 CALCA IL1B TNF
48 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
50 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CCL2 EDN1 IL10 IL1B IL6 TNF
2 hormone activity GO:0005179 9.33 CALCA EDN1 NPY
3 receptor binding GO:0005102 9.1 CALCA CCL2 EDN1 HLA-B IL6 NPY

Sources for Complex Regional Pain Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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