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CRPS
MCID: CMP010
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Complex Regional Pain Syndrome malady |
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Sources: 30NIH Rare Diseases, 23MedlinePlus, 31NINDS, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NINDS: Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather
than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied
by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory
symptoms of redness, warmth, and swelling in the affected area.31
MalaCards: Complex Regional Pain Syndrome, also known as reflex sympathetic dystrophy syndrome, is related to autonomic dysfunction and sepsis. An important gene associated with Complex Regional Pain Syndrome is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Graft-versus-host disease and RAR-Gamma-RXR-Alpha Degradation. The compounds ivig and calcitriol have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and nk cells, and related mouse phenotypes are hematopoietic system and respiratory system. NIH Rare Diseases: Complex regional pain syndrome is a chronic pain condition that mainly affects the arms or legs and is often triggered by injury. It is characterized by constant pain, sensitivity, and skin color and temperature changes at the site of an injury. The pain is out of proportion to the severity of the injury and worsens with time. Treatment aims to control these painful symptoms.30 MedlinePlus: Complex regional pain syndrome (crps) is an uncommon nerve disorder. it causes intense pain, usually in the arms, hands, legs or feet. it happens after an injury, either to a nerve or to tissue in the affected area. rest and time may only make it worse. doctors are not sure what causes it. symptoms in the affected area are dramatic changes in temperature and color intense burning pain extreme skin sensitivity the cause of crps is unknown, and there is no cure. it can get worse over time, and may spread to other parts of the body. occasionally it goes away, either temporarily or for good. treatment focuses on relieving the pain, and can include medicines, physical therapy and nerve blocks. nih: national institute of neurological disorders and stroke23 Wikipedia: Complex regional pain syndrome (CRPS), formerly reflex sympathetic dystrophy or causalgia, is a chronic...44 more... |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 31NINDS, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 24MeSH, 40SNOMED-CT See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for complex regional pain syndrome Drug clinical trials:Search ClinicalTrials for complex regional pain syndrome Search NIH Clinical Center for complex regional pain syndrome Search CenterWatch for complex regional pain syndrome |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to complex regional pain syndrome:22Skin, Monocytes, Nk cells
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to complex regional pain syndrome:25 (show all 20)
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Sources: 35PubMed See all sources |
Articles related to complex regional pain syndrome:(show all 30)
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Sources: 1BioGPS See all sources |
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Sources: 20KEGG, 36QIAGEN, 10EMD Millipore, 37R&D Systems, 41Thomson Reuters See all sources |
Pathways related to complex regional pain syndrome according to GeneDecks:(show top 50) (show all 79)
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Sources: 32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB See all sources |
Compounds related to complex regional pain syndrome according to GeneDecks:(show top 50) (show all 255)
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Sources: 12Gene Ontology See all sources |
Cellular components related to complex regional pain syndrome according to GeneDecks:
Biological processes related to complex regional pain syndrome according to GeneDecks:(show top 50) (show all 74)
Molecular functions related to complex regional pain syndrome according to GeneDecks:
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