MCID: CMP058
MIFTS: 35

Complex Regional Pain Syndrome Type 1 malady

Neuronal category

Summaries for Complex Regional Pain Syndrome Type 1

Sources:
47OMIM, 33MalaCards
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MalaCards: Complex Regional Pain Syndrome Type 1, also known as reflex sympathetic dystrophy, is related to arthritis and systemic lupus erythematosus. An important gene associated with Complex Regional Pain Syndrome Type 1 is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds endotoxin and hydrocortisone have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and cardiovascular system.

Description from OMIM:47 604335

Aliases & Classifications for Complex Regional Pain Syndrome Type 1

Sources:
49Orphanet, 61UMLS, 47OMIM, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

complex regional pain syndrome type 1 49 47
reflex sympathetic dystrophy 49 61
algodystrophic syndrome 61
algodystrophy 49


External Ids:

OMIM47 604335
ICD10 via Orphanet26 M89.0

Related Diseases for Complex Regional Pain Syndrome Type 1

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome Type 1:



Diseases related to complex regional pain syndrome type 1

Clinical Features for Complex Regional Pain Syndrome Type 1

Sources:
47OMIM
See all sources

Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome Type 1

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Complex Regional Pain Syndrome Type 1

Drug clinical trials:

Search ClinicalTrials for Complex Regional Pain Syndrome Type 1

Search NIH Clinical Center for Complex Regional Pain Syndrome Type 1

Search CenterWatch for Complex Regional Pain Syndrome Type 1

Genetic Tests for Complex Regional Pain Syndrome Type 1

Anatomical Context for Complex Regional Pain Syndrome Type 1

Animal Models for Complex Regional Pain Syndrome Type 1 or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome Type 1:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.7EDN1
2MP:00053859.1CXCR3, CALCA, EDN1
3MP:00053888.2IL6, CXCR3, TNF, CALCA
4MP:00020068.1CALCA, TNF, CXCR3, IL6
5MP:00107687.2CXCR3, CALCA, TNF, IL6, CXCL9, EDN1

Publications for Complex Regional Pain Syndrome Type 1

Genetic Variations for Complex Regional Pain Syndrome Type 1

Expression for genes affiliated with Complex Regional Pain Syndrome Type 1

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome Type 1

Search GEO for disease gene expression data for Complex Regional Pain Syndrome Type 1.

Pathways for genes affiliated with Complex Regional Pain Syndrome Type 1

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 12EMD Millipore
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Pathways related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CXCR3
2
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9.5CXCL9, CXCR3
39.5CXCR3, CXCL9
4
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9.5CXCR3, CXCL9
59.5CXCL9, CXCR3
69.5EDN1, CALCA
7
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9.0IL6, TNF
89.0TNF, IL6
99.0TNF, IL6
109.0TNF, IL6
119.0IL6, TNF
129.0IL6, TNF
139.0TNF, IL6
14
Hide members
8.6CXCL9, CXCR3, EDN1, CALCA
158.5TNF, EDN1, IL6
16
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8.5IL6, EDN1, TNF
17
Hide members
8.5TNF, CXCL9, IL6
18
Development PDGF signaling via STATs and NF-kB
Hide members
8.5IL6, CXCL9, TNF
19
Hide members
8.1TNF, CXCR3, CXCL9, IL6

Compounds for genes affiliated with Complex Regional Pain Syndrome Type 1

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.5CXCR3
2hydrocortisone45 2 60 1113.5CALCA
3indomethacin45 60 29 1113.4CALCA
4thiorphan45 29 1112.2EDN1
5herbimycin a45 6011.0TNF
6creatinine4510.0CXCR3, CXCL9
7cyclosporin a45 29 6011.9EDN1, CALCA
8meclofenamate459.9EDN1, CALCA
9cromakalim45 2910.9CALCA, EDN1
10mcp 1459.8IL6, CXCR3
11n(g)-nitro-l-arginine methyl ester459.7EDN1, CALCA
12pamidronate45 50 1111.7CALCA, IL6
13clodronate45 50 1111.7CALCA, IL6
14dexamethasone45 50 29 1112.7CXCL9, IL6
15ng-nitro-l-arginine459.6EDN1, CALCA
16pmma459.6CALCA, IL6
17cicaprost45 2910.5EDN1, TNF
18tocilizumab45 1110.4IL6, TNF
19abatacept45 1110.4IL6, TNF
20cdp571459.4TNF, IL6
21sodium nitroprusside459.4CXCL9, EDN1, CXCR3
22zoledronic acid459.4IL6, CALCA
23anakinra45 1110.4IL6, TNF
24vesnarinone459.4IL6, TNF
25taurine chloramine459.4TNF, IL6
26mip 1alpha459.3IL6, TNF
27ifn-alpha459.3CXCR3, CXCL9, IL6
28adalimumab45 50 1111.3IL6, TNF
29il-12459.3TNF, IL6
30carbenoxolone29 45 1111.2EDN1, IL6
31imiquimod45 29 60 1112.1IL6, TNF
32tarc459.1CXCR3, TNF, CXCL9
33tpck459.1IL6, TNF
34epinephrine45 11 2411.1CALCA, EDN1, IL6
35rantes459.0TNF, IL6, CXCR3
36etanercept45 50 1111.0CXCR3, IL6, TNF
37infliximab45 50 1111.0CXCR3, TNF, IL6
388-isoprostane458.9IL6, EDN1, TNF
39atorvastatin45 50 29 11 2412.9IL6, EDN1, TNF
40calcitriol45 60 11 2411.9TNF, IL6, CALCA
41apocynin45 609.8TNF, EDN1
42groalpha458.5TNF, IL6, CXCL9, CXCR3
43il 10458.5TNF, IL6, CXCR3, CXCL9
44ccl345 299.5IL6, CXCL9, CXCR3, TNF
45sb 20358045 609.5IL6, TNF, EDN1
46pd 98,059458.5IL6, CXCR3, EDN1, TNF
47thymidine45 249.5TNF, EDN1, IL6, CXCR3
48histamine45 29 249.6EDN1, CXCR3, IL6, CXCL9, TNF, CALCA
49vegf457.6TNF, CALCA, EDN1, IL6, CXCL9, CXCR3
50nitric oxide45 11 249.6CALCA, TNF, EDN1, IL6, CXCL9, CXCR3

GO Terms for genes affiliated with Complex Regional Pain Syndrome Type 1

Sources:
16Gene Ontology
See all sources

Cellular components related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0IL6, CXCL9, CXCR3, TNF
2extracellular regionGO:0055767.5IL6, CXCL9, EDN1, TNF, CALCA
3extracellular spaceGO:0056157.2CALCA, TNF, EDN1, CXCL9, IL6

Biological processes related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.8EDN1, CALCA
2monocyte chemotaxisGO:0025489.7CALCA, IL6
3negative regulation of hormone secretionGO:0468889.6IL6, EDN1
4response to amino acid stimulusGO:0432009.6IL6, EDN1
5response to heatGO:0094089.5CALCA, IL6
6elevation of cytosolic calcium ion concentrationGO:0072049.4CALCA, EDN1, CXCR3
7positive regulation of mitosisGO:0458409.4TNF, EDN1
8epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4TNF, IL6
9positive regulation of JUN kinase activityGO:0435079.4EDN1, TNF
10negative regulation of lipid storageGO:0108889.4TNF, IL6
11cell growthGO:0160499.3IL6, EDN1
12positive regulation of chemokine productionGO:0327229.3IL6, TNF
13cell-cell signalingGO:0072679.2CXCL9, EDN1, CALCA
14negative regulation of fat cell differentiationGO:0455999.2IL6, TNF
15defense response to Gram-positive bacteriumGO:0508309.2TNF, IL6
16positive regulation of interleukin-6 productionGO:0327559.2IL6, TNF
17humoral immune responseGO:0069599.1TNF, IL6
18positive regulation of MAP kinase activityGO:0434069.1EDN1, TNF
19calcium-mediated signalingGO:0197229.1TNF, EDN1, CXCR3
20response to mechanical stimulusGO:0096128.9TNF, IL6
21positive regulation of nitric oxide biosynthetic processGO:0454298.9TNF, IL6, EDN1
22positive regulation of smooth muscle cell proliferationGO:0486618.9EDN1, IL6, TNF
23positive regulation of peptidyl-serine phosphorylationGO:0331388.7TNF, IL6
24inflammatory responseGO:0069548.0TNF, IL6, CXCL9, CXCR3, CALCA

Molecular functions related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.0IL6, CXCL9, EDN1, TNF

Products for genes affiliated with Complex Regional Pain Syndrome Type 1

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  • Proteins
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  • Antibodies

Sources for Complex Regional Pain Syndrome Type 1

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet