MCID: CMP058
MIFTS: 38

Complex Regional Pain Syndrome Type 1 malady

Neuronal diseases category

Summaries for Complex Regional Pain Syndrome Type 1

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46OMIM, 32MalaCards
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MalaCards: Complex Regional Pain Syndrome Type 1, also known as reflex sympathetic dystrophy, is related to complex regional pain syndrome and neuropathy. An important gene associated with Complex Regional Pain Syndrome Type 1 is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds endotoxin and hydrocortisone have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and cardiovascular system.

Description from OMIM:46 604335

Aliases & Classifications for Complex Regional Pain Syndrome Type 1

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48Orphanet, 60UMLS, 46OMIM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

complex regional pain syndrome type 1 48 46
reflex sympathetic dystrophy 48 60
algodystrophic syndrome 60
algodystrophy 48


External Ids:

SNOMED-CT via Orphanet57 50642008
OMIM46 604335
ICD10 via Orphanet26 M89.0

Related Diseases for Complex Regional Pain Syndrome Type 1

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Complex Regional Pain Syndrome family:

complex regional pain syndrome type 1

Diseases related to Complex Regional Pain Syndrome Type 1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1complex regional pain syndrome31.8CALCA
2neuropathy30.8CALCA
3arthritis30.6TNF, IL6
4systemic lupus erythematosus30.4TNF, CXCR3, IL6
5migraine30.4CALCA
6hepatitis c30.2CXCR3
7ischemia30.2EDN1
8vascular disease30.2IL6, TNF
9psoriasis30.2TNF, CXCR3, CXCL9, IL6
10burns10.6
11hemiplegia10.5
12cerebritis10.5
13image syndrome10.5
14conversion disorder10.4
15osteogenesis imperfecta10.4
16bone fracture10.3
17myofascial pain syndrome10.3
18psoriatic arthritis10.3
19osteomalacia10.3
20algoneurodystrophy10.3
21lupus erythematosus10.3
22pancoast tumor10.3
23reflex sympathetic dystrophy10.3
24pain disorder10.3
25adult syndrome10.3
26scurvy10.3
27fasciitis10.3
28malignant peripheral nerve sheath tumor10.3
29panniculitis10.3
30chronic venous leg ulcers10.2
31arteriovenous fistula10.2
32cryoglobulinemia10.2
33antiphospholipid syndrome10.2
34familial mediterranean fever10.2
35lateral sclerosis10.2
36tarsal tunnel syndrome10.2
37radiculopathy10.2
38quadriplegia10.2
39lateral medullary syndrome10.2
40hidradenitis suppurativa10.2
41postphlebitic syndrome10.2
42fanconi syndrome10.2
43erythromelalgia10.2
44herpes zoster10.2
45hemarthrosis10.2
46irritable bowel syndrome10.2
47down syndrome10.2
48riley-day syndrome10.2
49diabetic autonomic neuropathy10.2
50hepatitis a10.2

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome Type 1:



Diseases related to complex regional pain syndrome type 1

Clinical Features for Complex Regional Pain Syndrome Type 1

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46OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome Type 1

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Complex Regional Pain Syndrome Type 1

Drug clinical trials:

Search ClinicalTrials for Complex Regional Pain Syndrome Type 1

Search NIH Clinical Center for Complex Regional Pain Syndrome Type 1

Search CenterWatch for Complex Regional Pain Syndrome Type 1

Genetic Tests for Complex Regional Pain Syndrome Type 1

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Anatomical Context for Complex Regional Pain Syndrome Type 1

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Animal Models for Complex Regional Pain Syndrome Type 1 or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome Type 1:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.7EDN1
2MP:00053859.1CXCR3, CALCA, EDN1
3MP:00053888.2IL6, CXCR3, TNF, CALCA
4MP:00020068.1CALCA, TNF, CXCR3, IL6
5MP:00107687.2CXCR3, CALCA, TNF, IL6, CXCL9, EDN1

Publications for Complex Regional Pain Syndrome Type 1

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Genetic Variations for Complex Regional Pain Syndrome Type 1

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Expression for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome Type 1

Search GEO for disease gene expression data for Complex Regional Pain Syndrome Type 1.

Pathways for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore
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Pathways related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CXCR3
2
Hide members
9.5CXCL9, CXCR3
39.5CXCR3, CXCL9
4
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9.5CXCR3, CXCL9
59.5CXCL9, CXCR3
69.5CALCA, EDN1
7
Hide members
9.0IL6, TNF
89.0TNF, IL6
99.0TNF, IL6
109.0IL6, TNF
119.0TNF, IL6
129.0TNF, IL6
139.0IL6, TNF
14
Hide members
8.6CXCL9, EDN1, CXCR3, CALCA
15
Hide members
8.5TNF, EDN1, IL6
168.5IL6, EDN1, TNF
17
Development PDGF signaling via STATs and NF-kB
Hide members
8.5CXCL9, TNF, IL6
18
Hide members
8.5IL6, CXCL9, TNF
19
Hide members
8.1CXCR3, TNF, CXCL9, IL6

Compounds for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.5CXCR3
2hydrocortisone44 2 59 1113.5CALCA
3indomethacin44 59 28 1113.4CALCA
4thiorphan44 28 1112.2EDN1
5herbimycin a44 5911.0TNF
6creatinine4410.0CXCR3, CXCL9
7cyclosporin a44 28 5911.9EDN1, CALCA
8meclofenamate449.9EDN1, CALCA
9cromakalim44 2810.9CALCA, EDN1
10mcp 1449.8IL6, CXCR3
11n(g)-nitro-l-arginine methyl ester449.7EDN1, CALCA
12pamidronate44 49 1111.7CALCA, IL6
13clodronate44 49 1111.7CALCA, IL6
14dexamethasone44 49 28 1112.7CXCL9, IL6
15ng-nitro-l-arginine449.6EDN1, CALCA
16pmma449.6CALCA, IL6
17cicaprost44 2810.5EDN1, TNF
18tocilizumab44 1110.4IL6, TNF
19abatacept44 1110.4IL6, TNF
20cdp571449.4TNF, IL6
21sodium nitroprusside449.4CXCL9, EDN1, CXCR3
22anakinra44 1110.4IL6, TNF
23vesnarinone449.4IL6, TNF
24taurine chloramine449.4TNF, IL6
25mip 1alpha449.3IL6, TNF
26ifn-alpha449.3CXCR3, CXCL9, IL6
27adalimumab44 49 1111.3IL6, TNF
28il-12449.3TNF, IL6
29carbenoxolone28 44 1111.2EDN1, IL6
30imiquimod44 28 59 1112.1IL6, TNF
31tarc449.1CXCR3, TNF, CXCL9
32tpck449.1IL6, TNF
33epinephrine44 11 2411.1CALCA, EDN1, IL6
34rantes449.0TNF, IL6, CXCR3
35etanercept44 49 1111.0CXCR3, IL6, TNF
36infliximab44 49 1111.0CXCR3, TNF, IL6
37polymyxin b449.0IL6, TNF
388-isoprostane448.9IL6, EDN1, TNF
39atorvastatin44 49 28 11 2412.9IL6, EDN1, TNF
40calcitriol44 59 11 2411.9TNF, IL6, CALCA
41apocynin44 599.8TNF, EDN1
42groalpha448.5TNF, IL6, CXCL9, CXCR3
43il 10448.5TNF, IL6, CXCR3, CXCL9
44ccl344 289.5IL6, CXCL9, CXCR3, TNF
45sb 20358044 599.5IL6, TNF, EDN1
46pd 98,059448.5IL6, CXCR3, EDN1, TNF
47thymidine44 249.5TNF, EDN1, IL6, CXCR3
48histamine44 28 249.6EDN1, CXCR3, IL6, CXCL9, TNF, CALCA
49vegf447.6TNF, CALCA, EDN1, IL6, CXCL9, CXCR3
50nitric oxide44 11 249.6CALCA, TNF, EDN1, IL6, CXCL9, CXCR3

GO Terms for genes affiliated with Complex Regional Pain Syndrome Type 1

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16Gene Ontology
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Cellular components related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.0TNF, CXCR3, CXCL9, IL6
2extracellular regionGO:0055767.5CALCA, TNF, EDN1, CXCL9, IL6
3extracellular spaceGO:0056157.2CALCA, TNF, EDN1, CXCL9, IL6

Biological processes related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.8EDN1, CALCA
2monocyte chemotaxisGO:0025489.7CALCA, IL6
3negative regulation of hormone secretionGO:0468889.6IL6, EDN1
4response to amino acid stimulusGO:0432009.6IL6, EDN1
5response to heatGO:0094089.5CALCA, IL6
6elevation of cytosolic calcium ion concentrationGO:0072049.4CALCA, EDN1, CXCR3
7positive regulation of mitosisGO:0458409.4TNF, EDN1
8epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4TNF, IL6
9positive regulation of JUN kinase activityGO:0435079.4EDN1, TNF
10negative regulation of lipid storageGO:0108889.4TNF, IL6
11cell growthGO:0160499.3IL6, EDN1
12positive regulation of chemokine productionGO:0327229.3IL6, TNF
13cell-cell signalingGO:0072679.2CXCL9, EDN1, CALCA
14negative regulation of fat cell differentiationGO:0455999.2IL6, TNF
15defense response to Gram-positive bacteriumGO:0508309.2TNF, IL6
16positive regulation of interleukin-6 productionGO:0327559.2IL6, TNF
17humoral immune responseGO:0069599.1TNF, IL6
18positive regulation of MAP kinase activityGO:0434069.1EDN1, TNF
19calcium-mediated signalingGO:0197229.1TNF, EDN1, CXCR3
20response to mechanical stimulusGO:0096128.9TNF, IL6
21positive regulation of nitric oxide biosynthetic processGO:0454298.9TNF, IL6, EDN1
22positive regulation of smooth muscle cell proliferationGO:0486618.9EDN1, IL6, TNF
23positive regulation of peptidyl-serine phosphorylationGO:0331388.7TNF, IL6
24inflammatory responseGO:0069548.0TNF, IL6, CXCL9, CXCR3, CALCA

Molecular functions related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.0IL6, CXCL9, EDN1, TNF

Products for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources for Complex Regional Pain Syndrome Type 1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet