MCID: CMP058
MIFTS: 51

Complex Regional Pain Syndrome Type 1 malady

Neuronal diseases, Rare diseases categories

Summaries for Complex Regional Pain Syndrome Type 1

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48OMIM, 34MalaCards
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MalaCards: Complex Regional Pain Syndrome Type 1, also known as reflex sympathetic dystrophy, is related to arthritis and systemic lupus erythematosus. An important gene associated with Complex Regional Pain Syndrome Type 1 is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and CXCR3-mediated signaling events. The compounds rantes and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Description from OMIM:48 604335

Aliases & Classifications for Complex Regional Pain Syndrome Type 1

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50Orphanet, 63UMLS, 48OMIM, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50

Aliases & Descriptions:

complex regional pain syndrome type 1 50 48
reflex sympathetic dystrophy 50 63
algodystrophic syndrome 63
algodystrophy 50


External Ids:

SNOMED-CT via Orphanet60 50642008
OMIM48 604335
ICD10 via Orphanet27 M89.0

Related Diseases for Complex Regional Pain Syndrome Type 1

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome Type 1:



Diseases related to complex regional pain syndrome type 1

Symptoms for Complex Regional Pain Syndrome Type 1

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48OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Complex Regional Pain Syndrome Type 1

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Complex Regional Pain Syndrome Type 1

Drug clinical trials:

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Search NIH Clinical Center for Complex Regional Pain Syndrome Type 1

Search CenterWatch for Complex Regional Pain Syndrome Type 1

Genetic Tests for Complex Regional Pain Syndrome Type 1

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Anatomical Context for Complex Regional Pain Syndrome Type 1

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34MalaCards
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MalaCards organs/tissues related to Complex Regional Pain Syndrome Type 1:

34
Skin, Spinal cord, Bone, Heart, Pituitary, Thalamus

Animal Models for Complex Regional Pain Syndrome Type 1 or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Complex Regional Pain Syndrome Type 1:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3IL6, CXCR3, TNF
2MP:00053858.1EDN1, TNF, CXCR3, IL6
3MP:00053878.1IL6, CXCR3, CXCL9, TNF
4MP:00053978.0TNF, CXCL9, CXCR3, IL6
5MP:00107687.6IL6, CXCR3, CXCL9, TNF, EDN1

Publications for Complex Regional Pain Syndrome Type 1

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53PubMed
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Articles related to Complex Regional Pain Syndrome Type 1:

(show top 50)    (show all 86)
idTitleAuthorsYear
1
Concurrence of malignant peripheral nerve sheath tumor at the site of complex regional pain syndrome type 1 - a case report -. (23614078)
2013
2
Health-related quality of life in 975 patients with complex regional pain syndrome type 1. (24342465)
2013
3
The role of pain coping and kinesiophobia in patients with complex regional pain syndrome type 1 of the legs. (23739533)
2013
4
Pain relief is associated with improvement in motor function in complex regional pain syndrome type 1: secondary analysis of a placebo-controlled study on the effects of ketamine. (24075073)
2013
5
Anti tumor necrosis factor - alpha adalimumab for complex regional pain syndrome type 1 (CRPS-I): a case series. (23668697)
2013
6
Successful reversal of complex regional pain syndrome type 1 of both upper extremities in five patients. (22776058)
2012
7
Concurrent peripheral pathologies and complex regional pain syndrome type 1 as contributors to acute post-stroke shoulder pain: a case report. (22592581)
2012
8
Predictors of pain relieving response to sympathetic blockade in complex regional pain syndrome type 1. (22143169)
2012
9
Is physiotherapy effective for children with complex regional pain syndrome type 1? (21677566)
2012
10
Hypothalamic-pituitary-adrenal axis function in patients with complex regional pain syndrome type 1. (22445364)
2012
11
The effectiveness and cost evaluation of pain exposure physical therapy and conventional therapy in patients with complex regional pain syndrome type 1. Rationale and design of a randomized controlled trial. (22515496)
2012
12
Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS I). (22841878)
2012
13
The association between psychological factors and the development of complex regional pain syndrome type 1 (CRPS1)--a prospective multicenter study. (21459637)
2011
14
Biopsychosocial complexity is correlated with psychiatric comorbidity but not with perceived pain in complex regional pain syndrome type 1 (algodystrophy) of the knee. (20851028)
2011
15
Evidence based guidelines for complex regional pain syndrome type 1. (20356382)
2010
16
Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I). (20675053)
2010
17
An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients. (19540140)
2010
18
The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type 1. (19910617)
2010
19
Complex regional pain syndrome (Type 1) following steroid injection for stenosing tenosynovitis. (20510663)
2010
20
Management of complex regional pain syndrome type 1 with total spinal block. (20552078)
2010
21
Mirror therapy for chronic complex regional pain syndrome type 1 and stroke. (19657134)
2009
22
Complex regional pain syndrome type 1 may be associated with menstrual cycle disorders: a case-control study. (19942105)
2009
23
Somatosensory conflicts in complex regional pain syndrome type 1 and fibromyalgia syndrome. (19922737)
2009
24
Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study. (19496957)
2009
25
The effect of sequel symptoms and signs of Complex Regional Pain Syndrome type 1 on upper extremity disability and quality of life. (18953539)
2009
26
IgE-mediated hypersensitivity: patients with complex regional pain syndrome type 1 (CRPS1) vs the Dutch population. A retrospective study. (18721169)
2009
27
Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review. (19573987)
2009
28
Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. (19604642)
2009
29
Tumor necrosis factor-alpha and interleukin-6 are not correlated with the characteristics of Complex Regional Pain Syndrome type 1 in 66 patients. (18055234)
2008
30
Using skin surface temperature to differentiate between complex regional pain syndrome type 1 patients after a fracture and control patients with various complaints after a fracture. (18165590)
2008
31
Increased plasma serotonin in complex regional pain syndrome type 1. (18499624)
2008
32
Increased plasma glutamate, glycine, and arginine levels in complex regional pain syndrome type 1. (18419723)
2008
33
Vasodilative effect of isosorbide dinitrate ointment in complex regional pain syndrome type 1. (18180642)
2008
34
Treatment of early complex regional pain syndrome type 1 by a combination of mannitol and dexamethasone. (18443050)
2008
35
Images in clinical medicine. Complex regional pain syndrome type 1. (18669429)
2008
36
Correlation between changes in regional cerebral blood flow and pain relief in complex regional pain syndrome type 1. (16714887)
2006
37
Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1. (17137491)
2006
38
Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system. (16689997)
2006
39
Physicians' assessments versus measured symptoms of complex regional pain syndrome type 1: presence and severity. (15818079)
2005
40
The fasciitis-panniculitis syndrome presenting as complex regional pain syndrome type 1: report of a case. (15722813)
2005
41
Bone loss in the contralateral asymptomatic hand in patients with complex regional pain syndrome type 1. (14691686)
2004
42
Presentation and treatment of complex regional pain syndrome type 1 in a 3 year old. (15277940)
2004
43
Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]. (15453912)
2004
44
A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). (12509620)
2003
45
Impact of upper limb complex regional pain syndrome type 1 on everyday life measured with a novel upper limb-activity monitor. (12507702)
2003
46
Referred sensations in patients with complex regional pain syndrome type 1. (12730522)
2003
47
What is a meaningful pain reduction in patients with complex regional pain syndrome type 1? (12966253)
2003
48
Intravenous regional blocks with guanethidine and prilocaine combined with physiotherapy: two children with complex regional pain syndrome, type 1. (12095024)
2002
49
Changes in regional cerebral blood flow in the thalamus after electroconvulsive therapy for patients with complex regional pain syndrome type 1 (preliminary case series). (12373706)
2002
50
Long-term outcome following sympathectomy for complex regional pain syndrome type 1 (RSD). (9268243)
1997

Variations for Complex Regional Pain Syndrome Type 1

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Expression for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Complex Regional Pain Syndrome Type 1

Search GEO for disease gene expression data for Complex Regional Pain Syndrome Type 1.

Pathways for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 54QIAGEN
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Pathways related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CXCL9, CXCR3
29.5CXCL9, CXCR3
39.3IL6, EDN1
49.1EDN1, TNF
5
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.0TNF, IL6
6
Show member pathways
thioredoxin pathway39
9.0IL6, TNF
79.0IL6, TNF
8
Show member pathways
9.0IL6, TNF
99.0IL6, TNF
10
Show member pathways
Immune response MIF in innate immunity response61
9.0TNF, IL6
119.0IL6, TNF
129.0IL6, TNF
13
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.0TNF, IL6
149.0IL6, TNF
159.0IL6, TNF
169.0TNF, IL6
179.0IL6, TNF
18
Show member pathways
IL27-mediated signaling events39
9.0TNF, IL6
199.0TNF, IL6
209.0IL6, TNF
219.0IL6, TNF
229.0TNF, IL6
239.0TNF, IL6
249.0TNF, IL6
259.0IL6, TNF
269.0TNF, IL6
27
Show member pathways
9.0EDN1, CXCL9, CXCR3
28
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.5EDN1, TNF, IL6
298.5EDN1, TNF, IL6
30
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.5IL6, CXCL9, TNF
31
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5IL6, CXCL9, TNF
32
Show member pathways
8.1TNF, CXCL9, CXCR3, IL6
33
Show member pathways
8.1TNF, CXCL9, CXCR3, IL6
34
Show member pathways
8.1TNF, CXCL9, CXCR3, IL6
35
Show member pathways
7.5IL6, CXCR3, CXCL9, TNF, EDN1

Compounds for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1rantes469.9CXCR3, CXCL9
2mcp 1469.7IL6, CXCR3
3cicaprost46 3010.5TNF, EDN1
4carbenoxolone46 30 1211.5IL6, EDN1
5tocilizumab46 1210.4IL6, TNF
6abatacept46 1210.4IL6, TNF
7cdp571469.4IL6, TNF
8tenidap46 3010.4TNF, IL6
9anakinra46 1210.4IL6, TNF
10vesnarinone469.4TNF, IL6
11taurine chloramine469.4TNF, IL6
12sodium nitroprusside469.4EDN1, CXCL9, CXCR3
13gabexate mesilate469.4TNF, IL6
14ulinastatin469.4IL6, TNF
15mip 1alpha469.3IL6, TNF
16il-12469.3TNF, IL6
17apocynin46 6210.3TNF, EDN1
18adalimumab46 52 1211.3IL6, TNF
19ifn-alpha469.3IL6, CXCR3, CXCL9
20imiquimod46 62 30 1212.3TNF, IL6
21tpck469.3TNF, IL6
22polymyxin b469.1IL6, TNF
23tarc469.1TNF, CXCL9, CXCR3
24leflunomide46 52 1211.1TNF, IL6
25okt3469.0TNF, IL6
26gm-csf46 3010.0IL6, TNF
27etanercept46 52 1211.0IL6, CXCR3, TNF
28infliximab46 52 1211.0TNF, CXCR3, IL6
29hydrocortisone46 3 62 1212.0TNF, CXCR3, IL6
308-isoprostane468.9EDN1, TNF, IL6
31atorvastatin46 52 30 25 1212.9IL6, TNF, EDN1
32herbimycin a46 629.9IL6, TNF, EDN1
33indomethacin46 30 62 1211.8EDN1, TNF, IL6
34sb 20358046 629.8IL6, TNF, EDN1
35ly294002468.8IL6, CXCR3, TNF
36creatinine468.8EDN1, CXCL9, CXCR3, IL6
37triptolide468.7IL6, TNF
38actinomycin d468.7EDN1, TNF, IL6
39groalpha468.5IL6, CXCR3, CXCL9, TNF
40il 10468.5TNF, CXCL9, CXCR3, IL6
41ccl346 309.5IL6, CXCR3, CXCL9, TNF
42endotoxin468.5TNF, CXCL9, CXCR3, IL6
43pd 98,059468.5EDN1, TNF, CXCR3, IL6
44pge2468.5EDN1, TNF, CXCR3, IL6
45thymidine46 259.5IL6, CXCR3, TNF, EDN1
46dexamethasone46 52 30 1211.4IL6, CXCR3, CXCL9, TNF
47genistein46 30 62 3 25 1213.4IL6, TNF, EDN1
48histamine46 30 2510.0EDN1, TNF, CXCL9, CXCR3, IL6
49vegf468.0IL6, CXCR3, CXCL9, TNF, EDN1
50nitric oxide46 25 1210.0EDN1, TNF, CXCL9, CXCR3, IL6

GO Terms for genes affiliated with Complex Regional Pain Syndrome Type 1

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17Gene Ontology
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Cellular components related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0IL6, CXCL9, TNF, EDN1
2external side of plasma membraneGO:0098978.0IL6, CXCR3, CXCL9, TNF
3extracellular spaceGO:0056157.7EDN1, TNF, CXCL9, IL6

Biological processes related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:0308169.9CXCR3, CXCL9
2positive regulation of cAMP-mediated signalingGO:0439509.9CXCR3, CXCL9
3positive regulation of release of sequestered calcium ion into cytosolGO:0512819.9CXCL9, CXCR3
4negative regulation of hormone secretionGO:0468889.7EDN1, IL6
5response to amino acidGO:0432009.7IL6, EDN1
6positive regulation of cytosolic calcium ion concentrationGO:0072049.6EDN1, CXCR3
7cell growthGO:0160499.6EDN1, IL6
8chemotaxisGO:0069359.6CXCR3, CXCL9
9cell surface receptor signaling pathwayGO:0071669.5CXCR3, EDN1
10positive regulation of JUN kinase activityGO:0435079.5TNF, EDN1
11positive regulation of mitosisGO:0458409.5TNF, EDN1
12positive regulation of MAP kinase activityGO:0434069.4TNF, EDN1
13negative regulation of lipid storageGO:0108889.4IL6, TNF
14epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4IL6, TNF
15positive regulation of chemokine productionGO:0327229.4IL6, TNF
16response to lipopolysaccharideGO:0324969.4EDN1, IL6
17defense response to Gram-positive bacteriumGO:0508309.4TNF, IL6
18negative regulation of fat cell differentiationGO:0455999.4IL6, TNF
19positive regulation of interleukin-6 productionGO:0327559.4TNF, IL6
20G-protein coupled receptor signaling pathwayGO:0071869.3EDN1, CXCL9, CXCR3
21positive regulation of peptidyl-serine phosphorylationGO:0331389.3TNF, IL6
22response to mechanical stimulusGO:0096129.3IL6, TNF
23humoral immune responseGO:0069599.3TNF, IL6
24positive regulation of protein kinase B signalingGO:0518979.3IL6, TNF
25response to glucocorticoidGO:0513849.3IL6, TNF
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2IL6, TNF
27defense response to virusGO:0516079.2IL6, CXCL9
28positive regulation of ERK1 and ERK2 cascadeGO:0703749.2IL6, TNF
29positive regulation of cell proliferationGO:0082849.2IL6, CXCR3, EDN1
30calcium-mediated signalingGO:0197229.1EDN1, TNF, CXCR3
31positive regulation of NF-kappaB transcription factor activityGO:0510929.0IL6, TNF
32positive regulation of nitric oxide biosynthetic processGO:0454298.9IL6, TNF, EDN1
33positive regulation of smooth muscle cell proliferationGO:0486618.9IL6, TNF, EDN1
34response to hypoxiaGO:0016668.8TNF, EDN1
35positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TNF, CXCR3, IL6
36inflammatory responseGO:0069548.5TNF, CXCL9, CXCR3, IL6

Molecular functions related to Complex Regional Pain Syndrome Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.0IL6, CXCL9, TNF, EDN1

Products for genes affiliated with Complex Regional Pain Syndrome Type 1

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Sources for Complex Regional Pain Syndrome Type 1

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet