MCID: CND002
MIFTS: 50

Conduct Disorder malady

Mental diseases category

Summaries for Conduct Disorder

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Disease Ontology:9 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.

MalaCards based summary: Conduct Disorder is related to attention deficit-hyperactivity disorder and oppositional defiant disorder. An important gene associated with Conduct Disorder is DRD5 (dopamine receptor D5), and among its related pathways are Dopamine metabolism and Serotonin clearance from the synaptic cleft. The drugs lithium and lithium carbonate and the compounds (+)-butaclamol and alpha-methyl-p-tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia:63 Conduct disorder (CD) is a psychological disorder diagnosed in childhood or adolescence that presents... more...

Aliases & Classifications for Conduct Disorder

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Conduct Disorder, Aliases & Descriptions:

Name: Conduct Disorder 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:12995
MeSH33 D019955
ICD9CM27 312.9
ICD1025 F91, F91.9

Related Diseases for Conduct Disorder

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Diseases related to Conduct Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit-hyperactivity disorder31.7SLC6A3, DRD4
2oppositional defiant disorder31.6DRD4, SLC6A3
3bipolar disorder30.8DRD2, SLC6A4
4alcohol dependence30.5DRD2, MAOA, DRD4, SLC6A4
5substance abuse30.5DRD4, DRD2, SLC6A4, SLC6A3
6antisocial personality disorder30.4DRD2, SLC6A4, SLC6A3, MAOA, TTF2
7schizophrenia30.3DRD2, COMT, DRD4, SLC6A4
8personality disorder30.3SLC6A3, TTF2, MAOA, DRD4, DRD2, SLC6A4
9borderline personality disorder30.2TTF2, MAOA, SLC6A4
10anxiety disorder30.1SLC6A4, MAOA
11drug dependence30.1DRD2, SLC6A3, MAOA, SLC6A4
12alcohol abuse30.0SLC6A3, SLC6A4, DRD2, COMT
13dementia29.9TTF2, COMT, MAOA, SLC6A3
14substance dependence29.8COMT, DRD4, DRD5, DRD2, SLC6A4, SLC6A3
15panic disorder29.5MAOA, TTF2, DRD4, SLC6A4, COMT
16obesity29.4SLC6A3, MAOA, COMT, DRD4, DRD2, TTF2
17melancholia10.5MAOA
18paranoid schizophrenia10.4COMT
19serotonin syndrome10.4MAOA
20alcoholic psychosis10.4SLC6A4
21premature ejaculation10.3SLC6A4
22delusional disorder10.3DRD2, DRD4
23focal dystonia10.3DRD5, DRD2
24heroin dependence10.3DRD2, DRD4
25lesch-nyhan syndrome10.3SLC6A3, MAOA
26striatonigral degeneration10.3SLC6A3, DRD2
27pure autonomic failure10.2MAOA, DBH
28generalized anxiety disorder10.2SLC6A4, MAOA
29endogenous depression10.2MAOA, SLC6A4
30drug addiction10.2DRD2, SLC6A3
31dilated cardiomyopathy10.2
32supranuclear palsy, progressive10.2DRD2, SLC6A3
33major depressive disorder and accelerated response to antidepressant drug treatment10.2DRD4, SLC6A4
34pathological gambling10.2DRD4, DRD2, SLC6A3
35neurotic disorder10.2MAOA, SLC6A4
36wilson disease10.1DRD2, SLC6A3
37opioid dependence10.1
38long qt syndrome10.1
39familial progressive cardiac conduction defect10.1
40blindness10.1
41fibromyalgia10.1COMT, SLC6A4
42chronic fatigue syndrome10.1SLC6A4, MAOA
43hypertension, essential10.1SLC6A4, DBH
44hyperprolactinemia10.1DRD4, DRD2, DBH
45narcolepsy10.1DRD2, COMT
46movement disease10.1SLC6A3, DRD2
47multiple system atrophy10.0DBH, DRD2, SLC6A3
48long qt syndrome 110.0
49timothy syndrome10.0
50jervell and lange-nielsen syndrome10.0

Graphical network of the top 20 diseases related to Conduct Disorder:



Diseases related to conduct disorder

Symptoms for Conduct Disorder

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Drugs & Therapeutics for Conduct Disorder

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Drug clinical trials:

Search ClinicalTrials for Conduct Disorder

Search NIH Clinical Center for Conduct Disorder

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Conduct Disorder

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Anatomical Context for Conduct Disorder

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MalaCards organs/tissues related to Conduct Disorder:

31
Brain, Testes, Cortex, Amygdala, Thyroid, Fetal brain, Temporal lobe

Animal Models for Conduct Disorder or affiliated genes

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MGI Mouse Phenotypes related to Conduct Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2DBH, DRD5, DRD2, SLC6A4, SLC6A3
2MP:00053857.7COMT, MAOA, DRD5, DRD2, SLC6A4, DBH
3MP:00053867.4SLC6A4, SLC6A3, MAOA, COMT, DBH, DRD4
4MP:00036317.2DBH, SLC6A4, DRD2, SLC6A3, DRD5, DRD4
5MP:00053767.1DBH, SLC6A3, SLC6A4, DRD2, DRD4, MAOA

Publications for Conduct Disorder

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Articles related to Conduct Disorder:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Estimating the causal effect of conduct disorder on the time from first substance use to substance use disorders using g-estimation. (24821350)
2014
2
Does diagnosis affect the predictive accuracy of risk assessment tools for juvenile offenders: Conduct Disorder and Attention Deficit Hyperactivity Disorder. (25173178)
2014
3
Determinants of symptom profile and severity of conduct disorder in a tertiary level pediatric care set up: A pilot study. (25568472)
2014
4
ADHD, Conduct Disorder, Substance Use Disorder, and Nonprescription Stimulant Use. (24776714)
2014
5
Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. (24687270)
2014
6
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia? (23015687)
2013
7
Multiple developmental pathways to conduct disorder: current conceptualizations and clinical implications. (23390429)
2013
8
Subclinical bulimia predicts conduct disorder in middle adolescent girls. (22504864)
2013
9
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
10
Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals. (24011986)
2013
11
The neurobiology of oppositional defiant disorder and conduct disorder: altered functioning in three mental domains. (22800761)
2013
12
Childhood conduct disorder trajectories, prior risk factors and cannabis use at age 16: birth cohort study. (23734913)
2013
13
Aripiprazole in children and adolescents with conduct disorder: a single-center, open-label study. (21993869)
2012
14
Parent-reported attention-deficit hyperactivity disorder and subtypes of conduct disorder as risk factor of recidivism in detained male adolescents. (21420836)
2012
15
The role of conduct disorder in the association between ADHD and alcohol use (disorder). Results from the Netherlands Mental Health Survey and Incidence Study-2. (22118715)
2012
16
Annual research review: phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology. (22211395)
2012
17
Adolescent-onset alcohol abuse exacerbates the influence of childhood conduct disorder on late adolescent and early adult antisocial behaviour. (23459369)
2011
18
Identification of attention-deficit-hyperactivity disorder and conduct disorder in Mexican children by the scale for evaluation of deficit of attention and hyperactivity. (20934222)
2011
19
Migration from Mexico to the United States and conduct disorder: a cross-national study. (22147845)
2011
20
Symptoms of conduct disorder, oppositional defiant disorder, attention-deficit/hyperactivity disorder, and callous-unemotional traits as unique predictors of psychosocial maladjustment in boys: advancing an evidence base for DSM-V. (20970701)
2010
21
Neuroanatomical correlates of attention-deficit-hyperactivity disorder accounting for comorbid oppositional defiant disorder and conduct disorder. (20546170)
2010
22
Dimensions of oppositional defiant disorder as predictors of depression and conduct disorder in preadolescent girls. (20431468)
2010
23
Impact of behavioral/developmental disorders comorbid with conduct disorder. (20021630)
2009
24
Effectiveness of lithium in children and adolescents with conduct disorder: a retrospective naturalistic study. (19062775)
2009
25
Service use patterns for adolescents with ADHD and comorbid conduct disorder. (18618263)
2009
26
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. (18413706)
2008
27
Conduct disorder in girls: neighborhoods, family characteristics, and parenting behaviors. (18837974)
2008
28
Early experience with racial discrimination and conduct disorder as predictors of subsequent drug use: a critical period hypothesis. (17275213)
2007
29
Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression. (17705899)
2007
30
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
31
Conduct disorder and antisocial personality disorder in persons with severe psychiatric and substance use disorders. (16574783)
2006
32
Potential mediators of cognitive-behavioral therapy for adolescents with comorbid major depression and conduct disorder. (15709830)
2005
33
The effect of childhood conduct disorder and cognitive functioning on adolescent substance use. (15337863)
2004
34
Reduced temporal lobe volume in early onset conduct disorder. (15546698)
2004
35
Genetic and environmental effects on conduct disorder and alcohol dependence symptoms and their covariation at age 14. (15597087)
2004
36
Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. (12733762)
2003
37
The relationship of conduct disorder to attempted suicide and drug use history among methadone maintenance patients. (12745355)
2003
38
The Maudsley long-term follow-up of child and adolescent depression: 3. Impact of comorbid conduct disorder on service use and costs in adulthood. (11772846)
2002
39
Decreased cortisol levels in adolescent girls with conduct disorder. (11231837)
2001
40
Childhood and adolescent onset conduct disorder: a test of the developmental taxonomy. (11523836)
2001
41
A double-blind placebo-controlled study of lithium in hospitalized aggressive children and adolescents with conduct disorder. (10891035)
2000
42
Conduct: Disorder in children and adolescents (21348167)
2000
43
Cognitive and familial contributions to conduct disorder in children. (10784080)
2000
44
Symptoms of posttraumatic stress disorder in adolescents with conduct disorder: sex differences and onset patterns. (11086558)
2000
45
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
46
Conduct disorder, antisocial personality disorder and substance use disorders in schizophrenia and major affective disorders. (10091967)
1999
47
Individual traits and family contexts predict sons' externalizing behavior and preliminary relative risk ratios for conduct disorder and substance use disorder outcomes. (10482403)
1999
48
Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. (10550498)
1999
49
Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. (10402507)
1999
50
Disruptive behavior, peer association, and conduct disorder: testing the developmental links through early intervention. (16506535)
1999

Variations for Conduct Disorder

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Expression for genes affiliated with Conduct Disorder

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Search GEO for disease gene expression data for Conduct Disorder.

Pathways for genes affiliated with Conduct Disorder

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Pathways related to Conduct Disorder according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MAOA, COMT
2
Show member pathways
9.7MAOA, COMT
39.7MAOA, COMT
49.7DRD2, DRD4
59.5SLC6A4, MAOA
6
Show member pathways
9.4DRD2, DRD5, DRD4
7
Show member pathways
9.4DRD2, DRD5, DRD4
89.4DRD4, DRD5, DRD2
9
Show member pathways
9.3COMT, MAOA, SLC6A3
10
Show member pathways
9.3MAOA, DRD2, SLC6A3
11
Show member pathways
catecholamine biosynthesis36
9.2MAOA, COMT, DBH
129.2DBH, COMT, MAOA
13
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.2DBH, COMT, MAOA
14
Show member pathways
Serotonin Transporter Activity36
8.6DBH, MAOA, SLC6A4, SLC6A3
15
Show member pathways
7.7SLC6A3, SLC6A4, DRD2, DRD5, DRD4, MAOA

Compounds for genes affiliated with Conduct Disorder

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Compounds related to Conduct Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol43 2810.7DRD2, DRD5, DRD4
2alpha-methyl-p-tyrosine439.4DBH, DRD2, SLC6A3
3ropinirole43 1210.4COMT, DRD2, DRD4, DRD5
4p-chloroamphetamine439.4MAOA, SLC6A4, SLC6A3
5pergolide43 28 1211.4COMT, DRD4, DRD5, DRD2
6benzamide2 4310.4MAOA, DRD4, DRD2
7carbon-11439.4SLC6A3, MAOA, SLC6A4
8cabergoline43 28 1211.3DRD2, COMT, DRD4, DRD5
9raclopride43 2810.3DRD4, SLC6A3, DRD2
10phentermine43 1210.3SLC6A3, MAOA, SLC6A4
11pseudoephedrine43 24 1211.2SLC6A3, MAOA, SLC6A4
12minaprine43 1210.1SLC6A4, DRD2, MAOA
13pramipexole43 28 49 1212.1DRD4, COMT, DRD5, DRD2, SLC6A3
14d amphetamine439.1SLC6A3, MAOA, DRD2, SLC6A4
15fluvoxamine43 49 1211.1SLC6A4, COMT, MAOA, SLC6A3
16apomorphine28 43 1211.1DRD5, DRD4, COMT, DRD2, SLC6A3
17bromocriptine43 28 1211.0SLC6A3, DRD5, COMT, DRD4, DRD2
18catecholamine438.9DBH, COMT, DRD4, DRD5, MAOA
19homovanillic acid43 249.9SLC6A4, MAOA, COMT, DBH
20bupropion49 43 24 1211.9COMT, DRD2, SLC6A4, SLC6A3
21fluoxetine43 49 28 1211.9SLC6A4, DRD2, SLC6A3, MAOA
22carbidopa43 289.9COMT, SLC6A3, DBH
23quetiapine43 49 28 24 1212.8SLC6A4, SLC6A3, DRD5, DRD4, DRD2
24paroxetine43 49 28 1211.8COMT, SLC6A3, SLC6A4, DRD4, MAOA
25haloperidol43 49 28 2 1212.8SLC6A4, DRD4, DRD5, DRD2, SLC6A3
26imipramine43 28 49 24 1212.8SLC6A3, SLC6A4, MAOA, DBH
27amphetamine43 49 1210.8MAOA, DRD4, DRD2, SLC6A3, SLC6A4
28heroin43 49 1210.7SLC6A3, COMT, DRD4, SLC6A4, DRD2
29mhpg438.7DBH, COMT, SLC6A4, DRD4, MAOA
30risperidone43 49 28 59 24 1213.7COMT, DRD2, DRD4, SLC6A3, SLC6A4
31carbon438.7SLC6A4, MAOA, COMT, TTF2, SLC6A3
32tyramine43 28 2410.6DBH, MAOA, SLC6A3, COMT, SLC6A4
33choline43 24 1210.5MAOA, SLC6A4, SLC6A3, COMT, DBH
346-hydroxydopamine438.5SLC6A3, COMT, DBH, MAOA, DRD4, DRD2
35olanzapine43 49 28 24 1212.5SLC6A4, COMT, DRD4, DRD5, DRD2, SLC6A3
36clozapine43 28 49 1211.4SLC6A3, SLC6A4, DRD2, DRD5, DRD4, COMT
37methamphetamine43 49 1210.4COMT, MAOA, DRD4, DRD2, SLC6A3, SLC6A4
38opiate438.4DBH, DRD2, SLC6A3, SLC6A4
39levodopa43 129.2COMT, MAOA, DBH, DRD5, DRD2, SLC6A3
40gaba438.2SLC6A4, MAOA, DRD4, DRD2, SLC6A3, DBH
41cocaine43 129.2DRD4, SLC6A4, SLC6A3, DRD2, COMT, DBH
42epinephrine43 24 1210.2SLC6A4, COMT, DBH, MAOA, DRD4, DRD2
43mptp438.2SLC6A3, SLC6A4, COMT, DRD2, MAOA, DBH
44methylphenidate43 49 1210.1COMT, DRD4, SLC6A3, SLC6A4, DRD2, DRD5
45maoa437.9DBH, SLC6A3, SLC6A4, DRD2, DRD4, MAOA
465-hydroxytryptamine437.9SLC6A4, COMT, MAOA, DRD4, DRD2, DBH
47glutamate437.7SLC6A3, DBH, COMT, DRD4, DRD2, SLC6A4
48norepinephrine43 24 129.6DRD2, SLC6A4, SLC6A3, DRD5, DRD4, MAOA
49dopamine43 28 24 1210.6DRD2, DRD5, DRD4, MAOA, COMT, SLC6A3
50nicotine43 28 49 1210.6DRD4, MAOA, COMT, DBH, TTF2, DRD2

GO Terms for genes affiliated with Conduct Disorder

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Cellular components related to Conduct Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.4SLC6A3, SLC6A4, DRD2, DRD5, DRD4

Biological processes related to Conduct Disorder according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:004205310.1SLC6A3, DRD4
2response to histamineGO:003477610.1DRD4, DRD2
3positive regulation of dopamine uptake involved in synaptic transmissionGO:005158610.1DRD2, DRD4
4negative regulation of voltage-gated calcium channel activityGO:0190138610.1DRD4, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:000719510.1DRD4, DRD2
6neurotransmitter catabolic processGO:004213510.1COMT, MAOA
7phospholipase C-activating dopamine receptor signaling pathwayGO:006015810.0DRD2, DRD5
8fear responseGO:004259610.0DBH, DRD4
9dopamine metabolic processGO:004241710.0DRD4, DRD2
10negative regulation of protein secretionGO:005070910.0DRD2, DRD4
11behavioral response to cocaineGO:004814810.0DRD4, DRD2
12adenohypophysis developmentGO:002198410.0DRD2, SLC6A3
13arachidonic acid secretionGO:005048210.0DRD4, DRD2
14associative learningGO:00083069.9DRD2, DRD5
15response to iron ionGO:00100399.9DRD2, SLC6A3
16prepulse inhibitionGO:00601349.9SLC6A3, DRD2
17negative regulation of adenylate cyclase activityGO:00071949.9DRD4, DRD2
18negative regulation of blood pressureGO:00457769.9DRD5, DRD2
19synaptic transmission, dopaminergicGO:00019639.8DRD2, DRD5, DRD4
20monoamine transportGO:00158449.8SLC6A3, SLC6A4
21response to nicotineGO:00350949.8SLC6A3, DRD2
22cellular calcium ion homeostasisGO:00068749.8DRD2, DRD5, DRD4
23response to painGO:00482659.8COMT, DBH
24response to cocaineGO:00422209.8SLC6A3, DRD2, DRD5
25neurotransmitter biosynthetic processGO:00421369.7SLC6A3, MAOA, COMT
26positive regulation of multicellular organism growthGO:00400189.7SLC6A3, DRD2
27behavioral response to ethanolGO:00481499.6DBH, DRD4, DRD2
28social behaviorGO:00351769.6SLC6A4, DRD4
29locomotory behaviorGO:00076269.5DBH, DRD2, SLC6A3
30visual learningGO:00085429.4DBH, DRD2
31memoryGO:00076139.3SLC6A4, DBH
32response to amphetamineGO:00019759.3DRD2, DRD5, DRD4, DBH
33circadian rhythmGO:00076239.3SLC6A4, DRD4
34dopamine catabolic processGO:00424209.2SLC6A3, MAOA, COMT, DBH
35response to drugGO:00424939.0COMT, DRD2, SLC6A4, SLC6A3
36synaptic transmissionGO:00072688.9DBH, COMT, MAOA, DRD5, SLC6A3

Molecular functions related to Conduct Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:000495210.0DRD4, DRD5
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.7DRD4, DRD2
3potassium channel regulator activityGO:00154599.7DRD2, DRD4
4drug bindingGO:00081449.2SLC6A3, DRD2, DRD4
5monoamine transmembrane transporter activityGO:00085049.2SLC6A3, SLC6A4
6dopamine bindingGO:00352409.2SLC6A3, DRD2, DRD5, DRD4

Products for genes affiliated with Conduct Disorder

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Sources for Conduct Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet