MCID: CND002
MIFTS: 59

Conduct Disorder malady

Neuronal diseases category

Summaries for Conduct Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.

MalaCards: Conduct Disorder is related to attention deficit hyperactivity disorder and personality disorder. An important gene associated with Conduct Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Circadian entrainment and Monoamine GPCRs. The drugs lithium and lithium carbonate and the compounds norepinephrine and nicotine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:63 Conduct disorder is a psychological disorder diagnosed in childhood or adolescence that presents itself... more...

Aliases & Classifications for Conduct Disorder

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Conduct Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Conduct Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.0SLC6A3, DRD4
2personality disorder30.9DRD2, DRD4, MAOA, TTF2, SLC6A3, SLC6A4
3antisocial personality disorder30.7DRD2, MAOA, TTF2, SLC6A3, SLC6A4
4alcohol dependence30.6SLC6A4, MAOA, DRD4, DRD2
5substance abuse30.6DRD2, DRD4, SLC6A3, SLC6A4
6substance dependence30.5COMT, DRD2, DRD4, DRD5, SLC6A3, SLC6A4
7bipolar disorder30.4MAOA, SLC6A4
8schizophrenia30.4COMT, DRD2, DRD4, DRD5, MAOA, DBH
9anxiety disorder30.3COMT, DRD2, MAOA, TTF2, SLC6A3, SLC6A4
10drug dependence30.2SLC6A4, SLC6A3, MAOA, DRD2
11borderline personality disorder30.1SLC6A4, TTF2, MAOA
12alcohol abuse30.1SLC6A4, SLC6A3, DRD2, COMT
13psychotic disorder30.0TTF2, SLC6A3, SLC6A4, DBH, MAOA, DRD4
14panic disorder29.8COMT, DRD4, MAOA, TTF2, SLC6A4
15nicotine dependence29.8DRD2, DRD4, SLC6A4
16dementia29.8SLC6A3, TTF2, MAOA, COMT
17obesity29.8COMT, DRD2, DRD4, MAOA, TTF2, SLC6A3
18major depressive disorder10.4
19dilated cardiomyopathy10.2
20long qt syndrome 110.2
21dependent personality disorder10.1
22adult syndrome10.1
23physical disorder10.1
24sexual disorder10.1
25jervell-lange nielsen syndrome10.0
26asperger syndrome10.0
27timothy syndrome10.0
28autism spectrum disorder10.0
29dissociative disorder10.0
30impulse control disorder10.0
31heart block, progressive, type ia10.0
32migraine10.0COMT, DRD2, DRD4, DRD5, MAOA, DBH
33mood disorder10.0COMT, DRD2, DRD4, MAOA, DBH, SLC6A3
34obsessive-compulsive disorder10.0DRD2, DRD4, MAOA, TTF2, SLC6A3, SLC6A4
35alzheimer's disease10.0COMT, DRD2, DRD4, MAOA, DBH, TTF2
36gilles de la tourette syndrome10.0DRD2, DRD4, DRD5, SLC6A3
37pathological gambling10.0DRD2, DRD4, SLC6A3
38cocaine dependence10.0SLC6A4, SLC6A3, DBH, DRD2
39anorexia nervosa10.0COMT, DRD4, MAOA, SLC6A4
40parkinson's disease10.0COMT, DRD2, MAOA, DBH, SLC6A3
41social phobia10.0COMT, DRD2, MAOA, SLC6A4
42bulimia nervosa10.0SLC6A4, MAOA, COMT
43heroin dependence10.0DRD2, DRD4
44schizoaffective disorder10.0COMT, DRD2, DRD4, SLC6A4
45cocaine abuse10.0SLC6A4, SLC6A3, DBH, DRD2
46restless legs syndrome10.0DRD2
47pheochromocytoma10.0COMT, DRD2, DBH, SLC6A3
48fibromyalgia10.0SLC6A4, COMT
49hypertension10.0SLC6A4, DBH
50ischemia10.0DRD2, SLC6A3, SELPLG

Graphical network of the top 20 diseases related to Conduct Disorder:



Diseases related to conduct disorder

Clinical Features for Conduct Disorder

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Drugs & Therapeutics for Conduct Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Conduct Disorder

Drug clinical trials:

Search ClinicalTrials for Conduct Disorder

Search NIH Clinical Center for Conduct Disorder

Search CenterWatch for Conduct Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Conduct Disorder

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Anatomical Context for Conduct Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Conduct Disorder:

32
Brain, Testes, Skin, Cortex, Amygdala, Heart, Thyroid, Fetal brain, Temporal lobe, Eye

Animal Models for Conduct Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Conduct Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.6COMT, DRD2, DRD4, NTSR2, MAOA, DBH
2MP:000363110.3COMT, DRD2, DRD4, DRD5, NTSR2, MAOA

Publications for Conduct Disorder

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Sources:
50PubMed
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Articles related to Conduct Disorder:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
2
Reward: empirical contribution: temporal discounting and conduct disorder in adolescents. (24344883)
2014
3
Adolescent caffeine consumption and self-reported violence and conduct disorder. (23358888)
2013
4
Relationship between anxiety, anxiety sensitivity and conduct disorder symptoms in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). (23460041)
2013
5
Exposure to maternal pre- and postnatal depression and anxiety symptoms: risk for major depression, anxiety disorders, and conduct disorder in adolescent offspring. (24229548)
2013
6
Impaired functional but preserved structural connectivity in limbic white matter tracts in youth with conduct disorder or oppositional defiant disorder plus psychopathic traits. (22819939)
2012
7
Empirically supported family-based treatments for conduct disorder and delinquency in adolescents. (22283380)
2012
8
An amygdala structural abnormality common to two subtypes of conduct disorder: a neurodevelopmental conundrum. (21642478)
2011
9
Patients' contexts and their effects on clinicians' impressions of conduct disorder symptoms. (21534058)
2011
10
Predictive validity of childhood oppositional defiant disorder and conduct disorder: implications for the DSM-V. (20853919)
2010
11
Neural abnormalities in early-onset and adolescence-onset conduct disorder. (20603454)
2010
12
AD/HD in the genesis of conduct disorder--does biopsychosocial approach make sense? (21169890)
2010
13
Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder. (19490304)
2009
14
A long-term follow-up study of adolescents with conduct disorder: Can outcome be predicted from self-concept and intelligence? (19513932)
2009
15
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (18951430)
2008
16
Early experience with racial discrimination and conduct disorder as predictors of subsequent drug use: a critical period hypothesis. (17275213)
2007
17
Adolescent conduct disorder and interpersonal callousness as predictors of psychopathy in young adults. (17658978)
2007
18
Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. (17909126)
2007
19
Onset of conduct disorder, use of delinquent subsistence strategies, and street victimization among homeless and runaway adolescents in the Midwest. (17704461)
2007
20
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
21
Conduct disorder and antisocial personality disorder in persons with severe psychiatric and substance use disorders. (16574783)
2006
22
A long-term follow-up of conduct disorder adolescents into adulthood. (17162455)
2006
23
Current perspectives on conduct disorder. (16513044)
2006
24
Conduct disorder-A sequelae of viral encephalitis. (20703348)
2006
25
Evidence-based practice for conduct disorder symptoms. (16327588)
2006
26
Conduct disorder: new directions in promoting effective parenting and strengthening parent-adolescent relationships. (18392190)
2006
27
Personality differences in children and adolescents with attention-deficit/hyperactivity disorder, conduct disorder, and controls. (16423146)
2006
28
The effect of childhood conduct disorder and cognitive functioning on adolescent substance use. (15337863)
2004
29
Gun carrying and conduct disorder: a highly combustible combination? Implications for juvenile justice and mental and public health. (14757605)
2004
30
Psychopharmacology of conduct disorder: current progress and future directions. (15155112)
2004
31
Theories of conduct disorder: a causal modelling analysis. (15056305)
2004
32
Internalizing antecedents of conduct disorder. (15065753)
2004
33
Response inhibition in children with conduct disorder and borderline intellectual functioning. (15590497)
2004
34
Drug-use initiation and conduct disorder among adolescents in drug treatment. (12770530)
2003
35
Emotional responses to antisocial acts in adolescent males with conduct disorder: a link to affective morality. (12679289)
2003
36
Family and parenting interventions for conduct disorder and delinquency: a meta-analysis of randomised controlled trials. (11919097)
2002
37
Should the DSM-IV diagnostic criteria for conduct disorder consider social context? (11870000)
2002
38
Predicting girls' conduct disorder in adolescence from childhood trajectories of disruptive behaviors. (11392346)
2001
39
Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorder. (11313079)
2001
40
Patterns of remission and symptom decline in conduct disorder: a four-year prospective study of an ADHD sample. (11288770)
2001
41
Looking for the disorder in conduct disorder. (11265675)
2001
42
Doing better with "bad kids": explaining the policy-research gap with conduct disorder in Canada. (12051030)
2001
43
Epidemiology of physical and sexual abuse in young persons diagnosed with conduct disorder: a retrospective chart review. (10652863)
2000
44
Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. (10402507)
1999
45
Association of the androgen receptor gene (AR) with ADHD and conduct disorder. (10380986)
1999
46
Age-of-onset classification of conduct disorder: reliability and validity in a prospective cohort study. (10434491)
1999
47
Conduct disorder and mania: what does it mean in adults. (9543210)
1998
48
The adolescent with conduct disorder. (10961242)
1998
49
Alcohol dependence and domestic violence as sequelae of abuse and conduct disorder in childhood. (9827313)
1998
50
Self-other differentiation among psychotic and conduct-disordered adolescents as measured by human figure drawings. (8483645)
1993

Genetic Variations for Conduct Disorder

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Expression for genes affiliated with Conduct Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conduct Disorder

Search GEO for disease gene expression data for Conduct Disorder.

Pathways for genes affiliated with Conduct Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Conduct Disorder

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Conduct Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2413.1MAOA, DRD2, DBH, DRD4, COMT, SLC6A4
2nicotine44 49 28 1114.1DBH, DRD4, DRD2, SLC6A4, SLC6A3, TTF2
3methylphenidate44 49 1113.1DRD5, DRD4, DRD2, COMT, SLC6A3, SLC6A4
4maoa4411.1SLC6A4, COMT, DRD2, DRD4, MAOA, DBH
5methamphetamine44 49 1113.0DRD2, COMT, MAOA, DRD4, SLC6A3, SLC6A4
6levodopa44 1112.0DRD4, DRD5, DRD2, DBH, SLC6A3, MAOA
7dopamine44 28 11 2414.0DRD5, ADRA2C, SLC6A4, SLC6A3, DBH, MAOA
8clozapine44 28 49 1114.0COMT, DRD5, SLC6A3, SLC6A4, ADRA2C, DRD2
9pramipexole44 49 28 1114.0ADRA2C, COMT, SLC6A3, DRD5, DRD4, DRD2
10apomorphine44 28 1113.0DRD4, DRD2, DRD5, SLC6A3, COMT, ADRA2C
11bromocriptine28 44 1113.0DRD5, ADRA2C, SLC6A3, DRD4, DRD2, COMT
12risperidone28 44 49 59 11 2416.0DRD4, SLC6A3, SLC6A4, ADRA2C, DRD2, COMT
136-hydroxydopamine4411.0SLC6A3, COMT, DRD2, DRD4, MAOA, DBH
145-hydroxytryptamine4411.0COMT, DRD2, DRD4, DBH, MAOA, SLC6A3
15olanzapine49 44 28 11 2415.0DRD5, DRD2, ADRA2C, SLC6A3, DRD4, COMT
16mhpg4411.0DRD4, SLC6A4, MAOA, DBH, COMT
17mptp4411.0SLC6A4, DRD2, SLC6A3, DBH, MAOA, COMT
18ropinirole44 1112.0DRD2, DRD4, DRD5, ADRA2C, COMT
19pergolide28 44 1113.0COMT, ADRA2C, DRD5, DRD4, DRD2
20tyramine44 28 2413.0COMT, SLC6A4, MAOA, SLC6A3, DBH
21catecholamine4411.0DRD4, MAOA, DRD5, ADRA2C, COMT, DBH
22cabergoline28 44 1113.0DRD5, DRD4, COMT, DRD2, ADRA2C
23heroin44 49 1113.0SLC6A4, DRD2, DRD4, COMT, SLC6A3
24paroxetine44 49 28 1114.0MAOA, COMT, SLC6A3, DRD4, SLC6A4
25quetiapine44 49 28 11 2414.9SLC6A3, DRD2, ADRA2C, DRD5, DRD4
26cocaine44 1111.9DBH, DRD2, COMT, SLC6A3, SLC6A4, DRD4
27d amphetamine4410.9SLC6A3, SLC6A4, DRD2, MAOA
28amphetamine44 1111.9DRD2, DRD4, SLC6A4, MAOA, SLC6A3
29Ephedra1110.9MAOA, ADRA2C, SLC6A4, SLC6A3
30lisuride28 44 1112.9DRD5, ADRA2C, DRD2, DRD4
31gaba4410.9DBH, SLC6A3, DRD4, DRD2, SLC6A4, MAOA
32homovanillic acid44 2411.9SLC6A4, DBH, MAOA, COMT
33Methotrimeprazine1110.9ADRA2C, DRD5, DRD4, DRD2
34aripiprazole28 49 44 11 2414.9DRD5, DRD4, DRD2, ADRA2C
35haloperidol44 28 2 49 1114.9SLC6A3, SLC6A4, DRD2, DRD5, DRD4
36alpha-methyl-p-tyrosine4410.8SLC6A3, DBH, DRD2
37bupropion44 49 11 2413.8SLC6A4, SLC6A3, COMT, DRD2
38ziprasidone49 28 44 1113.8DRD2, ADRA2C, DRD5, DRD4
39epinephrine44 11 2412.8DRD2, DRD4, MAOA, DBH, COMT, SLC6A4
40p-chloroamphetamine4410.8SLC6A3, SLC6A4, MAOA
41carbon-114410.8SLC6A3, MAOA, SLC6A4
42(+)-butaclamol28 4411.7DRD2, DRD4, DRD5
43MMDA1110.7MAOA, SLC6A4, SLC6A3
444-Methoxyamphetamine1110.7SLC6A3, MAOA, SLC6A4
45phentermine44 1111.6SLC6A4, SLC6A3, MAOA
46piribedil28 4411.6DRD2, DRD4, ADRA2C
47chlorpromazine44 28 49 1113.6DRD5, DRD2, ADRA2C, DRD4
48pseudoephedrine44 11 2412.5MAOA, SLC6A3, SLC6A4
49fluoxetine49 44 28 1113.4DRD2, MAOA, SLC6A3, SLC6A4
50benzamide44 211.2DRD2, DRD4, MAOA

GO Terms for genes affiliated with Conduct Disorder

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16Gene Ontology
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Cellular components related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6ADRA2C, SELPLG, SLC6A4, SLC6A3, NTSR2, DRD5

Biological processes related to Conduct Disorder according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.9SLC6A3, DBH, MAOA, COMT
2response to amphetamineGO:00197510.9DBH, DRD5, DRD4, DRD2
3behavioral response to ethanolGO:04814910.9DRD2, DRD4, DBH
4synaptic transmission, dopaminergicGO:00196310.9DRD5, DRD4, DRD2
5neurotransmitter biosynthetic processGO:04213610.9SLC6A3, MAOA, COMT
6synaptic transmissionGO:00726810.9SLC6A3, DBH, MAOA, DRD5, COMT
7response to cocaineGO:04222010.9DRD2, DRD5, SLC6A3
8response to histamineGO:03477610.9DRD4, DRD2
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.9DRD4, DRD2
10negative regulation of voltage-gated calcium channel activityGO:190138610.9DRD4, DRD2
11fear responseGO:04259610.8DRD4, DBH
12adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD4, DRD2
13monoamine transportGO:01584410.8SLC6A3, SLC6A4
14adenohypophysis developmentGO:02198410.8SLC6A3, DRD2
15neurotransmitter catabolic processGO:04213510.8MAOA, COMT
16phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.8DRD2, DRD5
17regulation of dopamine metabolic processGO:04205310.8DRD4, SLC6A3
18locomotory behaviorGO:00762610.8DRD2, DBH, SLC6A3
19cellular calcium ion homeostasisGO:00687410.8DRD5, DRD4, DRD2
20dopamine metabolic processGO:04241710.7DRD4, DRD2
21negative regulation of protein secretionGO:05070910.7DRD2, DRD4
22behavioral response to cocaineGO:04814810.7DRD2, DRD4
23response to iron ionGO:01003910.6DRD2, SLC6A3
24response to drugGO:04249310.6SLC6A4, SLC6A3, DRD2, COMT
25associative learningGO:00830610.5DRD5, DRD2
26prepulse inhibitionGO:06013410.5DRD2, SLC6A3
27arachidonic acid secretionGO:05048210.4DRD4, DRD2
28response to painGO:04826510.2DBH, COMT

Molecular functions related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.6SLC6A3, DRD5, DRD4, DRD2
2drug bindingGO:00814410.5SLC6A3, DRD4, DRD2
3dopamine neurotransmitter receptor activityGO:00495210.5DRD4, DRD5
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.4DRD2, DRD4
5monoamine transmembrane transporter activityGO:00850410.2SLC6A4, SLC6A3

Products for genes affiliated with Conduct Disorder

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Sources for Conduct Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet