MCID: CND002
MIFTS: 59

Conduct Disorder malady

Mental diseases, Fetal diseases categories
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Summaries for Conduct Disorder

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.

MalaCards: Conduct Disorder is related to attention deficit hyperactivity disorder and oppositional defiant disorder. An important gene associated with Conduct Disorder is DRD5 (dopamine receptor D5), and among its related pathways are Dopamine metabolism and Serotonin clearance from the synaptic cleft. The drugs lithium and lithium carbonate and the compounds (+)-butaclamol and benzamide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia:65 Conduct disorder (CD) is a psychological disorder diagnosed in childhood or adolescence that presents... more...

Aliases & Classifications for Conduct Disorder

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Conduct Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Conduct Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.2SLC6A3, DRD4
2oppositional defiant disorder31.1DRD4, SLC6A3
3personality disorder30.7SLC6A3, TTF2, MAOA, DRD4, DRD2, SLC6A4
4antisocial personality disorder30.6DRD2, SLC6A4, SLC6A3, MAOA, TTF2
5alcohol dependence30.6DRD2, MAOA, DRD4, SLC6A4
6bipolar disorder30.6MAOA, SLC6A4
7substance abuse30.6DRD4, DRD2, SLC6A4, SLC6A3
8substance dependence30.3COMT, DRD4, DRD5, DRD2, SLC6A4, SLC6A3
9borderline personality disorder30.2TTF2, MAOA, SLC6A4
10drug dependence30.1DRD2, SLC6A3, MAOA, SLC6A4
11schizophrenia30.1MAOA, DRD4, DRD5, DRD2, SLC6A4, SLC6A3
12anxiety disorder29.9SLC6A4, MAOA
13nicotine dependence29.9SLC6A4, DRD2, DRD4
14dementia29.8TTF2, COMT, MAOA, SLC6A3
15alcohol abuse29.8SLC6A3, SLC6A4, DRD2, COMT
16panic disorder29.8MAOA, TTF2, DRD4, SLC6A4, COMT
17obesity29.7SLC6A3, MAOA, COMT, DRD4, DRD2, TTF2
18dilated cardiomyopathy10.2
19long qt syndrome 110.2
20blindness10.1
21melancholia10.1MAOA
22paranoid schizophrenia10.1COMT
23serotonin syndrome10.1MAOA
24alcoholic psychosis10.1SLC6A4
25premature ejaculation10.1SLC6A4
26delusional disorder10.1DRD2, DRD4
27focal dystonia10.1DRD5, DRD2
28heroin dependence10.1DRD2, DRD4
29lesch-nyhan syndrome10.1SLC6A3, MAOA
30striatonigral degeneration10.1SLC6A3, DRD2
31pure autonomic failure10.1MAOA, DBH
32generalized anxiety disorder10.1SLC6A4, MAOA
33endogenous depression10.0MAOA, SLC6A4
34drug addiction10.0DRD2, SLC6A3
35progressive supranuclear palsy10.0DRD2, SLC6A3
36seasonal affective disorder10.0DRD4, SLC6A4
37major depressive disorder10.0
38jervell-lange nielsen syndrome10.0
39timothy syndrome10.0
40asperger syndrome10.0
41autism spectrum disorder10.0
42heart block, progressive, type ia10.0
43pathological gambling10.0DRD4, DRD2, SLC6A3
44wilson disease10.0DRD2, SLC6A3
45fibromyalgia10.0COMT, SLC6A4
46chronic fatigue syndrome10.0SLC6A4, MAOA
47hypertension10.0SLC6A4, DBH
48hyperprolactinemia10.0DRD4, DRD2, DBH
49essential hypertension10.0DBH, DRD5, COMT
50narcolepsy10.0DRD2, COMT

Graphical network of the top 20 diseases related to Conduct Disorder:



Diseases related to conduct disorder

Symptoms for Conduct Disorder

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Drugs & Therapeutics for Conduct Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Conduct Disorder

Search NIH Clinical Center for Conduct Disorder

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Conduct Disorder

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Anatomical Context for Conduct Disorder

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33MalaCards
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MalaCards organs/tissues related to Conduct Disorder:

33
Brain, Testes, Cortex, Amygdala, Thyroid, Fetal brain, Temporal lobe

Animal Models for Conduct Disorder or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Conduct Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2DBH, DRD5, DRD2, SLC6A4, SLC6A3
2MP:00053857.7COMT, MAOA, DRD5, DRD2, SLC6A4, DBH
3MP:00053867.4SLC6A4, SLC6A3, MAOA, COMT, DBH, DRD4
4MP:00036317.2DBH, SLC6A4, DRD2, SLC6A3, DRD5, DRD4
5MP:00053767.1DBH, SLC6A3, SLC6A4, DRD2, DRD4, MAOA

Publications for Conduct Disorder

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Sources:
52PubMed
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Articles related to Conduct Disorder:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia? (23015687)
2013
2
Multiple developmental pathways to conduct disorder: current conceptualizations and clinical implications. (23390429)
2013
3
Subclinical bulimia predicts conduct disorder in middle adolescent girls. (22504864)
2013
4
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
5
Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals. (24011986)
2013
6
The neurobiology of oppositional defiant disorder and conduct disorder: altered functioning in three mental domains. (22800761)
2013
7
Childhood conduct disorder trajectories, prior risk factors and cannabis use at age 16: birth cohort study. (23734913)
2013
8
Aripiprazole in children and adolescents with conduct disorder: a single-center, open-label study. (21993869)
2012
9
Parent-reported attention-deficit hyperactivity disorder and subtypes of conduct disorder as risk factor of recidivism in detained male adolescents. (21420836)
2012
10
The role of conduct disorder in the association between ADHD and alcohol use (disorder). Results from the Netherlands Mental Health Survey and Incidence Study-2. (22118715)
2012
11
Annual research review: phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology. (22211395)
2012
12
Identification of attention-deficit-hyperactivity disorder and conduct disorder in Mexican children by the scale for evaluation of deficit of attention and hyperactivity. (20934222)
2011
13
Migration from Mexico to the United States and conduct disorder: a cross-national study. (22147845)
2011
14
The impact of ADHD and conduct disorder in childhood on adult delinquency: a 30 years follow-up study using official crime records. (21481227)
2011
15
Symptoms of conduct disorder, oppositional defiant disorder, attention-deficit/hyperactivity disorder, and callous-unemotional traits as unique predictors of psychosocial maladjustment in boys: advancing an evidence base for DSM-V. (20970701)
2010
16
Neuroanatomical correlates of attention-deficit-hyperactivity disorder accounting for comorbid oppositional defiant disorder and conduct disorder. (20546170)
2010
17
Dimensions of oppositional defiant disorder as predictors of depression and conduct disorder in preadolescent girls. (20431468)
2010
18
Impact of behavioral/developmental disorders comorbid with conduct disorder. (20021630)
2009
19
Effectiveness of lithium in children and adolescents with conduct disorder: a retrospective naturalistic study. (19062775)
2009
20
Service use patterns for adolescents with ADHD and comorbid conduct disorder. (18618263)
2009
21
Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. (18829871)
2009
22
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. (18413706)
2008
23
Conduct disorder in girls: neighborhoods, family characteristics, and parenting behaviors. (18837974)
2008
24
Early experience with racial discrimination and conduct disorder as predictors of subsequent drug use: a critical period hypothesis. (17275213)
2007
25
Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression. (17705899)
2007
26
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
27
Conduct disorder and antisocial personality disorder in persons with severe psychiatric and substance use disorders. (16574783)
2006
28
Potential mediators of cognitive-behavioral therapy for adolescents with comorbid major depression and conduct disorder. (15709830)
2005
29
The effect of childhood conduct disorder and cognitive functioning on adolescent substance use. (15337863)
2004
30
Reduced temporal lobe volume in early onset conduct disorder. (15546698)
2004
31
Genetic and environmental effects on conduct disorder and alcohol dependence symptoms and their covariation at age 14. (15597087)
2004
32
Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. (12733762)
2003
33
The relationship of conduct disorder to attempted suicide and drug use history among methadone maintenance patients. (12745355)
2003
34
The Maudsley long-term follow-up of child and adolescent depression: 3. Impact of comorbid conduct disorder on service use and costs in adulthood. (11772846)
2002
35
ADHD and conduct disorder: an MRI study in a community sample. (12516313)
2002
36
Decreased cortisol levels in adolescent girls with conduct disorder. (11231837)
2001
37
Childhood and adolescent onset conduct disorder: a test of the developmental taxonomy. (11523836)
2001
38
Risk factors in childhood that lead to the development of conduct disorder and antisocial personality disorder. (11196010)
2001
39
Predicting girls' conduct disorder in adolescence from childhood trajectories of disruptive behaviors. (11392346)
2001
40
A double-blind placebo-controlled study of lithium in hospitalized aggressive children and adolescents with conduct disorder. (10891035)
2000
41
Conduct: Disorder in children and adolescents (21348167)
2000
42
Cognitive and familial contributions to conduct disorder in children. (10784080)
2000
43
Symptoms of posttraumatic stress disorder in adolescents with conduct disorder: sex differences and onset patterns. (11086558)
2000
44
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
45
Conduct disorder, antisocial personality disorder and substance use disorders in schizophrenia and major affective disorders. (10091967)
1999
46
Individual traits and family contexts predict sons' externalizing behavior and preliminary relative risk ratios for conduct disorder and substance use disorder outcomes. (10482403)
1999
47
Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. (10550498)
1999
48
Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. (10402507)
1999
49
Disruptive behavior, peer association, and conduct disorder: testing the developmental links through early intervention. (16506535)
1999
50
Conduct disorder and mania: what does it mean in adults. (9543210)
1998

Variations for Conduct Disorder

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Expression for genes affiliated with Conduct Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conduct Disorder

Search GEO for disease gene expression data for Conduct Disorder.

Pathways for genes affiliated with Conduct Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 53QIAGEN, 30KEGG, 60Thomson Reuters
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Pathways related to Conduct Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MAOA, COMT
2
Show member pathways
9.7MAOA, COMT
39.7MAOA, COMT
49.7DRD2, DRD4
59.5SLC6A4, MAOA
6
Show member pathways
9.4DRD2, DRD5, DRD4
7
Show member pathways
9.4DRD2, DRD5, DRD4
89.4DRD4, DRD5, DRD2
9
Show member pathways
9.3COMT, MAOA, SLC6A3
10
Show member pathways
9.3MAOA, DRD2, SLC6A3
11
Show member pathways
catecholamine biosynthesis38
9.2MAOA, COMT, DBH
129.2DBH, COMT, MAOA
13
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.2DBH, COMT, MAOA
14
Show member pathways
Serotonin Transporter Activity38
8.6DBH, MAOA, SLC6A4, SLC6A3
15
Show member pathways
7.7SLC6A3, SLC6A4, DRD2, DRD5, DRD4, MAOA

Compounds for genes affiliated with Conduct Disorder

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Sources:
45Novoseek, 29IUPHAR, 3BitterDB, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Conduct Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol45 2910.7DRD4, DRD2, DRD5
2benzamide3 4510.4MAOA, DRD4, DRD2
3rotigotine29 45 1111.4DRD4, DRD5, DRD2
4alpha-methyl-p-tyrosine459.4DBH, SLC6A3, DRD2
5ropinirole45 1110.4DRD2, DRD5, COMT, DRD4
6p-chloroamphetamine459.4SLC6A3, MAOA, SLC6A4
7pergolide45 29 1111.4DRD5, DRD2, DRD4, COMT
8carbon-11459.4MAOA, SLC6A4, SLC6A3
9cabergoline45 29 1111.3DRD5, COMT, DRD4, DRD2
10phentermine45 1110.3SLC6A3, SLC6A4, MAOA
11minaprine45 1110.2DRD2, MAOA, SLC6A4
12pseudoephedrine45 24 1111.1MAOA, SLC6A4, SLC6A3
13pramipexole45 29 51 1112.1SLC6A3, DRD2, DRD4, COMT, DRD5
14d amphetamine459.1MAOA, DRD2, SLC6A3, SLC6A4
15fluvoxamine45 51 1111.1COMT, SLC6A4, SLC6A3, MAOA
16apomorphine29 45 1111.1COMT, DRD4, DRD5, DRD2, SLC6A3
17raclopride45 2910.0SLC6A3, DRD2, DRD4
18bromocriptine45 29 1111.0SLC6A3, DRD2, DRD5, DRD4, COMT
19catecholamine458.9COMT, MAOA, DBH, DRD4, DRD5
20homovanillic acid45 249.9MAOA, COMT, DBH, SLC6A4
21bupropion51 45 24 1111.9DRD2, COMT, SLC6A3, SLC6A4
22fluoxetine45 51 29 1111.9SLC6A3, MAOA, DRD2, SLC6A4
23paroxetine45 51 29 1111.8SLC6A3, COMT, MAOA, SLC6A4, DRD4
24quetiapine45 51 29 24 1112.8SLC6A4, DRD2, DRD5, DRD4, SLC6A3
25haloperidol45 51 29 3 1112.8SLC6A4, DRD4, DRD5, SLC6A3, DRD2
26imipramine45 29 51 24 1112.8DBH, SLC6A4, SLC6A3, MAOA
27amphetamine45 51 1110.8MAOA, DRD4, DRD2, SLC6A4, SLC6A3
28heroin45 51 1110.7DRD2, SLC6A4, SLC6A3, DRD4, COMT
29mhpg458.7SLC6A4, DRD4, DBH, COMT, MAOA
30risperidone45 51 29 61 24 1113.7SLC6A4, COMT, DRD4, DRD2, SLC6A3
31carbon458.7SLC6A3, SLC6A4, TTF2, MAOA, COMT
32tyramine45 29 2410.6COMT, SLC6A4, SLC6A3, MAOA, DBH
33choline45 24 1110.5SLC6A4, SLC6A3, DBH, MAOA, COMT
346-hydroxydopamine458.5MAOA, DBH, DRD4, DRD2, SLC6A3, COMT
35olanzapine45 51 29 24 1112.5SLC6A3, DRD2, DRD5, DRD4, COMT, SLC6A4
36clozapine45 29 51 1111.4DRD4, DRD2, SLC6A4, SLC6A3, COMT, DRD5
37methamphetamine45 51 1110.4SLC6A3, SLC6A4, DRD4, DRD2, COMT, MAOA
38opiate458.4SLC6A3, DRD2, SLC6A4, DBH
39levodopa45 119.2SLC6A3, COMT, MAOA, DRD4, DRD5, DRD2
40gaba458.2SLC6A4, DRD2, DRD4, MAOA, DBH, SLC6A3
41cocaine45 119.2SLC6A3, DRD2, DBH, COMT, SLC6A4, DRD4
42epinephrine45 24 1110.2DRD4, MAOA, DRD2, DBH, COMT, SLC6A4
43mptp458.2DBH, SLC6A4, SLC6A3, DRD2, MAOA, COMT
44methylphenidate45 51 1110.1COMT, MAOA, DRD4, DRD5, SLC6A4, SLC6A3
45maoa457.9COMT, MAOA, DRD4, DRD2, SLC6A4, SLC6A3
465-hydroxytryptamine457.9SLC6A3, SLC6A4, DRD2, DBH, MAOA, DRD4
47glutamate457.7MAOA, DRD4, COMT, DBH, SLC6A4, DRD2
48norepinephrine45 24 119.6DRD4, MAOA, DRD5, SLC6A3, DBH, COMT
49dopamine45 29 24 1110.6DRD5, DRD2, SLC6A4, DRD4, MAOA, DBH
50nicotine45 29 51 1110.6DRD4, SLC6A4, DRD2, COMT, DBH, TTF2

GO Terms for genes affiliated with Conduct Disorder

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Sources:
16Gene Ontology
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Cellular components related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.4SLC6A3, SLC6A4, DRD2, DRD5, DRD4

Biological processes related to Conduct Disorder according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:04205310.1SLC6A3, DRD4
2response to histamineGO:03477610.1DRD4, DRD2
3positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.1DRD2, DRD4
4negative regulation of voltage-gated calcium channel activityGO:190138610.1DRD4, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD4, DRD2
6neurotransmitter catabolic processGO:04213510.1COMT, MAOA
7phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.0DRD2, DRD5
8fear responseGO:04259610.0DBH, DRD4
9dopamine metabolic processGO:04241710.0DRD4, DRD2
10negative regulation of protein secretionGO:05070910.0DRD2, DRD4
11behavioral response to cocaineGO:04814810.0DRD4, DRD2
12adenohypophysis developmentGO:02198410.0DRD2, SLC6A3
13arachidonic acid secretionGO:05048210.0DRD4, DRD2
14associative learningGO:0083069.9DRD2, DRD5
15response to iron ionGO:0100399.9DRD2, SLC6A3
16prepulse inhibitionGO:0601349.9SLC6A3, DRD2
17negative regulation of adenylate cyclase activityGO:0071949.9DRD4, DRD2
18negative regulation of blood pressureGO:0457769.9DRD5, DRD2
19synaptic transmission, dopaminergicGO:0019639.8DRD2, DRD5, DRD4
20monoamine transportGO:0158449.8SLC6A3, SLC6A4
21response to nicotineGO:0350949.8SLC6A3, DRD2
22cellular calcium ion homeostasisGO:0068749.8DRD2, DRD5, DRD4
23response to painGO:0482659.8COMT, DBH
24response to cocaineGO:0422209.8SLC6A3, DRD2, DRD5
25neurotransmitter biosynthetic processGO:0421369.7SLC6A3, MAOA, COMT
26positive regulation of multicellular organism growthGO:0400189.7SLC6A3, DRD2
27behavioral response to ethanolGO:0481499.6DBH, DRD4, DRD2
28social behaviorGO:0351769.6SLC6A4, DRD4
29locomotory behaviorGO:0076269.5DBH, DRD2, SLC6A3
30visual learningGO:0085429.4DBH, DRD2
31memoryGO:0076139.3SLC6A4, DBH
32response to amphetamineGO:0019759.3DRD2, DRD5, DRD4, DBH
33circadian rhythmGO:0076239.3SLC6A4, DRD4
34dopamine catabolic processGO:0424209.2SLC6A3, MAOA, COMT, DBH
35response to drugGO:0424939.0COMT, DRD2, SLC6A4, SLC6A3
36synaptic transmissionGO:0072688.9DBH, COMT, MAOA, DRD5, SLC6A3

Molecular functions related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.0DRD4, DRD5
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.7DRD4, DRD2
3potassium channel regulator activityGO:0154599.7DRD2, DRD4
4drug bindingGO:0081449.2SLC6A3, DRD2, DRD4
5monoamine transmembrane transporter activityGO:0085049.2SLC6A3, SLC6A4
6dopamine bindingGO:0352409.2SLC6A3, DRD2, DRD5, DRD4

Products for genes affiliated with Conduct Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Conduct Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet