MCID: CND002
MIFTS: 59

Conduct Disorder malady

Neuronal diseases category

Summaries for Conduct Disorder

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.

MalaCards: Conduct Disorder is related to attention deficit hyperactivity disorder and personality disorder. An important gene associated with Conduct Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Circadian entrainment and Monoamine GPCRs. The drugs lithium and lithium carbonate and the compounds norepinephrine and nicotine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:63 Conduct disorder is a psychological disorder diagnosed in childhood or adolescence that presents itself... more...

Aliases & Classifications for Conduct Disorder

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Conduct Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Conduct Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.0SLC6A3, DRD4
2personality disorder30.9DRD2, DRD4, MAOA, TTF2, SLC6A3, SLC6A4
3antisocial personality disorder30.7DRD2, MAOA, TTF2, SLC6A3, SLC6A4
4alcohol dependence30.6SLC6A4, MAOA, DRD4, DRD2
5substance abuse30.6DRD2, DRD4, SLC6A3, SLC6A4
6substance dependence30.5COMT, DRD2, DRD4, DRD5, SLC6A3, SLC6A4
7bipolar disorder30.4MAOA, SLC6A4
8schizophrenia30.4COMT, DRD2, DRD4, DRD5, MAOA, DBH
9anxiety disorder30.3COMT, DRD2, MAOA, TTF2, SLC6A3, SLC6A4
10drug dependence30.2SLC6A4, SLC6A3, MAOA, DRD2
11borderline personality disorder30.1SLC6A4, TTF2, MAOA
12alcohol abuse30.1SLC6A4, SLC6A3, DRD2, COMT
13psychotic disorder30.0TTF2, SLC6A3, SLC6A4, DBH, MAOA, DRD4
14panic disorder29.8COMT, DRD4, MAOA, TTF2, SLC6A4
15nicotine dependence29.8DRD2, DRD4, SLC6A4
16dementia29.8SLC6A3, TTF2, MAOA, COMT
17obesity29.8COMT, DRD2, DRD4, MAOA, TTF2, SLC6A3
18major depressive disorder10.4
19dilated cardiomyopathy10.2
20long qt syndrome 110.2
21dependent personality disorder10.1
22adult syndrome10.1
23physical disorder10.1
24sexual disorder10.1
25jervell-lange nielsen syndrome10.0
26asperger syndrome10.0
27timothy syndrome10.0
28autism spectrum disorder10.0
29dissociative disorder10.0
30impulse control disorder10.0
31heart block, progressive, type ia10.0
32migraine10.0COMT, DRD2, DRD4, DRD5, MAOA, DBH
33mood disorder10.0COMT, DRD2, DRD4, MAOA, DBH, SLC6A3
34obsessive-compulsive disorder10.0DRD2, DRD4, MAOA, TTF2, SLC6A3, SLC6A4
35alzheimer's disease10.0COMT, DRD2, DRD4, MAOA, DBH, TTF2
36gilles de la tourette syndrome10.0DRD2, DRD4, DRD5, SLC6A3
37pathological gambling10.0DRD2, DRD4, SLC6A3
38cocaine dependence10.0SLC6A4, SLC6A3, DBH, DRD2
39anorexia nervosa10.0COMT, DRD4, MAOA, SLC6A4
40parkinson's disease10.0COMT, DRD2, MAOA, DBH, SLC6A3
41social phobia10.0COMT, DRD2, MAOA, SLC6A4
42bulimia nervosa10.0SLC6A4, MAOA, COMT
43heroin dependence10.0DRD2, DRD4
44schizoaffective disorder10.0COMT, DRD2, DRD4, SLC6A4
45cocaine abuse10.0SLC6A4, SLC6A3, DBH, DRD2
46restless legs syndrome10.0DRD2
47pheochromocytoma10.0COMT, DRD2, DBH, SLC6A3
48fibromyalgia10.0SLC6A4, COMT
49hypertension10.0SLC6A4, DBH
50ischemia10.0DRD2, SLC6A3, SELPLG

Graphical network of the top 20 diseases related to Conduct Disorder:



Diseases related to conduct disorder

Clinical Features for Conduct Disorder

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Drugs & Therapeutics for Conduct Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Conduct Disorder

Drug clinical trials:

Search ClinicalTrials for Conduct Disorder

Search NIH Clinical Center for Conduct Disorder

Search CenterWatch for Conduct Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Conduct Disorder

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Anatomical Context for Conduct Disorder

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32MalaCards
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MalaCards organs/tissues related to Conduct Disorder:

32
Brain, Testes, Skin, Cortex, Amygdala, Heart, Thyroid, Fetal brain, Temporal lobe, Eye

Animal Models for Conduct Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Conduct Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.6DRD2, DRD4, NTSR2, MAOA, DBH, SLC6A3
2MP:000363110.3ADRA2C, COMT, DRD2, DRD4, DRD5, NTSR2

Publications for Conduct Disorder

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Sources:
50PubMed
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Articles related to Conduct Disorder:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Subclinical bulimia predicts conduct disorder in middle adolescent girls. (22504864)
2013
2
Association between DRD2/DRD4 interaction and conduct disorder: a potential developmental pathway to alcohol dependence. (23818181)
2013
3
Frontotemporal white-matter microstructural abnormalities in adolescents with conduct disorder: a diffusion tensor imaging study. (22617495)
2013
4
The usefulness of DSM-IV and DSM-5 conduct disorder subtyping in detained adolescents. (23995028)
2013
5
On the link between attention deficit/hyperactivity disorder and obesity: do comorbid oppositional defiant and conduct disorder matter? (24197170)
2013
6
Overt Versus Covert Conduct Disorder Symptoms and the Prospective Prediction of Antisocial Personality Disorder. (23398101)
2013
7
Gender differences in comorbidity of conduct disorder among adolescents in Northern Finland. (22456039)
2012
8
Comparison of brain volume abnormalities between ADHD and conduct disorder in adolescence. (22663946)
2012
9
Abnormal anatomical connectivity between the amygdala and orbitofrontal cortex in conduct disorder. (23144970)
2012
10
Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. (21934640)
2012
11
Effect of paternal alcohol and drug dependence on offspring conduct disorder: gene-environment interplay. (20731970)
2010
12
Age of onset, symptom threshold, and expansion of the nosology of conduct disorder for girls. (20853913)
2010
13
DHEA and DHEA-S levels in hospitalized adolescents with first-episode schizophrenia and conduct disorder: a comparison study. (19351578)
2009
14
The relationship between attention deficit hyperactivity disorder, conduct disorder, and psychopathy in adolescent male and female detainees. (19387992)
2009
15
Psychiatry and politics in Pelotas, Brazil: the equivocal quality of conduct disorder and related diagnoses. (20092054)
2009
16
Conduct disorder in girls: neighborhoods, family characteristics, and parenting behaviors. (18837974)
2008
17
Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA. (17803831)
2008
18
From conduct disorder to severe mental illness: a risky pathway. (18070370)
2008
19
ADHD with comorbid oppositional defiant disorder or conduct disorder: discrete or nondistinct disruptive behavior disorders? (17934178)
2008
20
Similar autonomic responsivity in boys with conduct disorder and their fathers. (17420689)
2007
21
The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence. (16956733)
2007
22
Parenting training improves problem behaviour in children at risk of conduct disorder. (17962687)
2007
23
Sex differences in child-onset, life-course-persistent conduct disorder. A review of biological influences. (17331630)
2007
24
Prevalence of conduct disorder in schoolchildren of Kanke. (20844646)
2006
25
Diagnosis and treatment of conduct disorder. (23234656)
2006
26
Potential mediators of cognitive-behavioral therapy for adolescents with comorbid major depression and conduct disorder. (15709830)
2005
27
Temperament and parenting: implications for understanding developmental pathways to conduct disorder. (16402009)
2005
28
Symptom-based subfactors of DSM-defined conduct disorder: evidence for etiologic distinctions. (16117586)
2005
29
A new look at inter-informant agreement on conduct disorder using a latent class approach. (15572187)
2004
30
Subfactors of DSM-IV conduct disorder: evidence and connections with syndromes from the Child Behavior Checklist. (14658744)
2003
31
New phenotype of familial dilated cardiomyopathy and conduction disorders. (12595850)
2003
32
Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program. (12788240)
2003
33
Family and parenting interventions for conduct disorder and delinquency: a meta-analysis of randomized controlled trials. (12448428)
2002
34
Review: family and parenting interventions reduce subsequent arrests and length of time in institutions in youths with conduct disorder and delinquency. (12440465)
2002
35
Childhood behavioral profiles leading to adolescent conduct disorder: risk trajectories for boys and girls. (12218430)
2002
36
Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorder. (11914177)
2002
37
Effects of chronic paroxetine administration on measures of aggressive and impulsive responses of adult males with a history of conduct disorder. (11862359)
2002
38
Early-onset alcoholism with conduct disorder: go/no go learning deficits, working memory capacity, and personality. (11964558)
2002
39
Conversational behaviour of children with Asperger syndrome and conduct disorder. (12120863)
2002
40
Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. (11605076)
2001
41
Conduct disorder: a challenge to child psychiatry. (11582819)
2001
42
CSD/BEM localization of P300 sources in adolescents "at-risk": evidence of frontal cortex dysfunction in conduct disorder. (11690595)
2001
43
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
44
Oppositional defiant and conduct disorder: a review of the past 10 years, part I. (11128323)
2000
45
Cohort differences in genetic and environmental influences on retrospective reports of conduct disorder among adult male twins. (11037085)
2000
46
Social and psychiatric functioning in adolescents with Asperger syndrome compared with conduct disorder. (11039855)
2000
47
Conduct disorder, antisocial personality disorder and substance use disorders in schizophrenia and major affective disorders. (10091967)
1999
48
Individual traits and family contexts predict sons' externalizing behavior and preliminary relative risk ratios for conduct disorder and substance use disorder outcomes. (10482403)
1999
49
Callous-unemotional traits and subtypes of conduct disorder. (11227072)
1999
50
Reversible somatotropin deficiency (psychosocial dwarfism) presenting as conduct disorder and growth hormone deficiency. (2286309)
1990

Genetic Variations for Conduct Disorder

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Expression for genes affiliated with Conduct Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conduct Disorder

Search GEO for disease gene expression data for Conduct Disorder.

Pathways for genes affiliated with Conduct Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Conduct Disorder

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Conduct Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2413.1MAOA, DRD2, DBH, DRD4, COMT, SLC6A4
2nicotine44 49 28 1114.1DBH, DRD4, DRD2, SLC6A4, SLC6A3, TTF2
3methylphenidate44 49 1113.1DRD5, DRD4, DRD2, COMT, SLC6A3, SLC6A4
4maoa4411.1SLC6A4, COMT, DRD2, DRD4, MAOA, DBH
5methamphetamine44 49 1113.0DRD2, COMT, MAOA, DRD4, SLC6A3, SLC6A4
6levodopa44 1112.0DRD4, DRD5, DRD2, DBH, SLC6A3, MAOA
7dopamine44 28 11 2414.0DRD5, ADRA2C, SLC6A4, SLC6A3, DBH, MAOA
8clozapine44 28 49 1114.0COMT, DRD5, SLC6A3, SLC6A4, ADRA2C, DRD2
9pramipexole44 49 28 1114.0ADRA2C, COMT, SLC6A3, DRD5, DRD4, DRD2
10apomorphine44 28 1113.0DRD4, DRD2, DRD5, SLC6A3, COMT, ADRA2C
11bromocriptine28 44 1113.0DRD5, ADRA2C, SLC6A3, DRD4, DRD2, COMT
12risperidone28 44 49 59 11 2416.0DRD4, SLC6A3, SLC6A4, ADRA2C, DRD2, COMT
136-hydroxydopamine4411.0SLC6A3, COMT, DRD2, DRD4, MAOA, DBH
145-hydroxytryptamine4411.0COMT, DRD2, DRD4, DBH, MAOA, SLC6A3
15olanzapine49 44 28 11 2415.0DRD5, DRD2, ADRA2C, SLC6A3, DRD4, COMT
16mhpg4411.0DRD4, SLC6A4, MAOA, DBH, COMT
17mptp4411.0SLC6A4, DRD2, SLC6A3, DBH, MAOA, COMT
18ropinirole44 1112.0DRD2, DRD4, DRD5, ADRA2C, COMT
19pergolide28 44 1113.0COMT, ADRA2C, DRD5, DRD4, DRD2
20tyramine44 28 2413.0COMT, SLC6A4, MAOA, SLC6A3, DBH
21catecholamine4411.0DRD4, MAOA, DRD5, ADRA2C, COMT, DBH
22cabergoline28 44 1113.0DRD5, DRD4, COMT, DRD2, ADRA2C
23heroin44 49 1113.0SLC6A4, DRD2, DRD4, COMT, SLC6A3
24paroxetine44 49 28 1114.0MAOA, COMT, SLC6A3, DRD4, SLC6A4
25quetiapine44 49 28 11 2414.9SLC6A3, DRD2, ADRA2C, DRD5, DRD4
26cocaine44 1111.9DBH, DRD2, COMT, SLC6A3, SLC6A4, DRD4
27d amphetamine4410.9SLC6A3, SLC6A4, DRD2, MAOA
28amphetamine44 1111.9DRD2, DRD4, SLC6A4, MAOA, SLC6A3
29Ephedra1110.9MAOA, ADRA2C, SLC6A4, SLC6A3
30lisuride28 44 1112.9DRD5, ADRA2C, DRD2, DRD4
31gaba4410.9DBH, SLC6A3, DRD4, DRD2, SLC6A4, MAOA
32homovanillic acid44 2411.9SLC6A4, DBH, MAOA, COMT
33Methotrimeprazine1110.9ADRA2C, DRD5, DRD4, DRD2
34aripiprazole28 49 44 11 2414.9DRD5, DRD4, DRD2, ADRA2C
35haloperidol44 28 2 49 1114.9SLC6A3, SLC6A4, DRD2, DRD5, DRD4
36alpha-methyl-p-tyrosine4410.8SLC6A3, DBH, DRD2
37bupropion44 49 11 2413.8SLC6A4, SLC6A3, COMT, DRD2
38ziprasidone49 28 44 1113.8DRD2, ADRA2C, DRD5, DRD4
39epinephrine44 11 2412.8COMT, DRD2, MAOA, SLC6A4, DRD4, DBH
40p-chloroamphetamine4410.8SLC6A3, MAOA, SLC6A4
41carbon-114410.8SLC6A3, SLC6A4, MAOA
42(+)-butaclamol28 4411.7DRD2, DRD4, DRD5
43phentermine44 1111.7SLC6A4, MAOA, SLC6A3
444-Methoxyamphetamine1110.7SLC6A4, SLC6A3, MAOA
45MMDA1110.6SLC6A4, SLC6A3, MAOA
46piribedil28 4411.6DRD4, DRD2, ADRA2C
47chlorpromazine44 28 49 1113.6ADRA2C, DRD4, DRD5, DRD2
48minaprine44 1111.5DRD2, MAOA, SLC6A4
49fluoxetine49 44 28 1113.4SLC6A3, SLC6A4, DRD2, MAOA
50benzamide44 211.2MAOA, DRD4, DRD2

GO Terms for genes affiliated with Conduct Disorder

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Sources:
16Gene Ontology
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Cellular components related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.6ADRA2C, SELPLG, SLC6A4, SLC6A3, NTSR2, DRD5

Biological processes related to Conduct Disorder according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.9SLC6A3, DBH, MAOA, COMT
2response to amphetamineGO:00197510.9DBH, DRD5, DRD4, DRD2
3behavioral response to ethanolGO:04814910.9DRD2, DRD4, DBH
4synaptic transmission, dopaminergicGO:00196310.9DRD5, DRD4, DRD2
5neurotransmitter biosynthetic processGO:04213610.9SLC6A3, MAOA, COMT
6synaptic transmissionGO:00726810.9SLC6A3, DBH, MAOA, DRD5, COMT
7response to cocaineGO:04222010.9DRD2, DRD5, SLC6A3
8response to histamineGO:03477610.9DRD4, DRD2
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.9DRD4, DRD2
10negative regulation of voltage-gated calcium channel activityGO:190138610.9DRD4, DRD2
11fear responseGO:04259610.8DRD4, DBH
12adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD4, DRD2
13monoamine transportGO:01584410.8SLC6A3, SLC6A4
14adenohypophysis developmentGO:02198410.8SLC6A3, DRD2
15neurotransmitter catabolic processGO:04213510.8MAOA, COMT
16phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.8DRD2, DRD5
17regulation of dopamine metabolic processGO:04205310.8DRD4, SLC6A3
18locomotory behaviorGO:00762610.8DRD2, DBH, SLC6A3
19cellular calcium ion homeostasisGO:00687410.8DRD5, DRD4, DRD2
20dopamine metabolic processGO:04241710.7DRD4, DRD2
21negative regulation of protein secretionGO:05070910.7DRD2, DRD4
22behavioral response to cocaineGO:04814810.7DRD2, DRD4
23response to iron ionGO:01003910.6DRD2, SLC6A3
24response to drugGO:04249310.6SLC6A4, SLC6A3, DRD2, COMT
25associative learningGO:00830610.5DRD5, DRD2
26prepulse inhibitionGO:06013410.5DRD2, SLC6A3
27arachidonic acid secretionGO:05048210.4DRD4, DRD2
28response to painGO:04826510.2DBH, COMT

Molecular functions related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.6SLC6A3, DRD5, DRD4, DRD2
2drug bindingGO:00814410.5SLC6A3, DRD4, DRD2
3dopamine neurotransmitter receptor activityGO:00495210.5DRD4, DRD5
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.4DRD2, DRD4
5monoamine transmembrane transporter activityGO:00850410.2SLC6A4, SLC6A3

Products for genes affiliated with Conduct Disorder

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Sources for Conduct Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet