MCID: CND002
MIFTS: 59

Conduct Disorder malady

Mental diseases, Fetal diseases categories
Download this MalaCard

Summaries for Conduct Disorder

About this section


Fully expand this MalaCard
Disease Ontology:8 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.

MalaCards based summary: Conduct Disorder is related to attention deficit hyperactivity disorder and oppositional defiant disorder. An important gene associated with Conduct Disorder is DRD5 (dopamine receptor D5), and among its related pathways are Dopamine metabolism and Serotonin clearance from the synaptic cleft. The drugs lithium and lithium carbonate and the compounds (+)-butaclamol and benzamide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia:65 Conduct disorder (CD) is a psychological disorder diagnosed in childhood or adolescence that presents... more...

Aliases & Classifications for Conduct Disorder

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Conduct Disorder, Aliases & Descriptions:

Name: Conduct Disorder 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:12995
ICD9CM27 312.9
MeSH34 D019955
ICD1025 F91, F91.9

Related Diseases for Conduct Disorder

About this section

Diseases related to Conduct Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.6SLC6A3, DRD4
2oppositional defiant disorder31.6DRD4, SLC6A3
3bipolar disorder30.8MAOA, SLC6A4
4alcohol dependence30.5DRD2, MAOA, DRD4, SLC6A4
5substance abuse30.4DRD4, DRD2, SLC6A4, SLC6A3
6antisocial personality disorder30.4DRD2, SLC6A4, SLC6A3, MAOA, TTF2
7borderline personality disorder30.4TTF2, MAOA, SLC6A4
8personality disorder30.3SLC6A3, TTF2, MAOA, DRD4, DRD2, SLC6A4
9anxiety disorder30.1SLC6A4, MAOA
10drug dependence30.1DRD2, SLC6A3, MAOA, SLC6A4
11alcohol abuse30.0SLC6A3, SLC6A4, DRD2, COMT
12nicotine dependence30.0SLC6A4, DRD2, DRD4
13substance dependence29.9COMT, DRD4, DRD5, DRD2, SLC6A4, SLC6A3
14dementia29.9TTF2, COMT, MAOA, SLC6A3
15panic disorder29.6MAOA, TTF2, DRD4, SLC6A4, COMT
16obesity29.4SLC6A3, MAOA, COMT, DRD4, DRD2, TTF2
17schizophrenia29.1MAOA, DRD4, DRD5, DRD2, SLC6A4, SLC6A3
18melancholia10.5MAOA
19paranoid schizophrenia10.5COMT
20serotonin syndrome10.4MAOA
21alcoholic psychosis10.4SLC6A4
22premature ejaculation10.3SLC6A4
23delusional disorder10.3DRD2, DRD4
24focal dystonia10.3DRD5, DRD2
25heroin dependence10.3DRD2, DRD4
26lesch-nyhan syndrome10.3SLC6A3, MAOA
27striatonigral degeneration10.3SLC6A3, DRD2
28pure autonomic failure10.2MAOA, DBH
29generalized anxiety disorder10.2SLC6A4, MAOA
30endogenous depression10.2MAOA, SLC6A4
31drug addiction10.2DRD2, SLC6A3
32dilated cardiomyopathy10.2
33long qt syndrome 110.2
34progressive supranuclear palsy10.2DRD2, SLC6A3
35seasonal affective disorder10.2DRD4, SLC6A4
36pathological gambling10.2DRD4, DRD2, SLC6A3
37wilson disease10.2DRD2, SLC6A3
38blindness10.1
39fibromyalgia10.1COMT, SLC6A4
40chronic fatigue syndrome10.1SLC6A4, MAOA
41hypertension10.1SLC6A4, DBH
42hyperprolactinemia10.1DRD4, DRD2, DBH
43essential hypertension10.1DBH, DRD5, COMT
44narcolepsy10.1DRD2, COMT
45movement disease10.1SLC6A3, DRD2
46multiple system atrophy10.1DBH, DRD2, SLC6A3
47major depressive disorder10.1
48jervell-lange nielsen syndrome10.1
49asperger syndrome10.1
50timothy syndrome10.1

Graphical network of the top 20 diseases related to Conduct Disorder:



Diseases related to conduct disorder

Symptoms for Conduct Disorder

About this section

Drugs & Therapeutics for Conduct Disorder

About this section

Drug clinical trials:

Search ClinicalTrials for Conduct Disorder

Search NIH Clinical Center for Conduct Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Conduct Disorder

About this section

Anatomical Context for Conduct Disorder

About this section

MalaCards organs/tissues related to Conduct Disorder:

32
Brain, Testes, Cortex, Amygdala, Thyroid, Fetal brain, Temporal lobe

Animal Models for Conduct Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Conduct Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2SLC6A3, SLC6A4, DRD2, DRD5, DBH
2MP:00053857.7DBH, COMT, MAOA, DRD5, DRD2, SLC6A4
3MP:00053867.4DBH, COMT, MAOA, DRD4, DRD2, SLC6A4
4MP:00036317.2SLC6A3, DBH, COMT, MAOA, DRD4, DRD5
5MP:00053767.1DBH, COMT, MAOA, DRD4, DRD2, SLC6A4

Publications for Conduct Disorder

About this section

Articles related to Conduct Disorder:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Estimating the causal effect of conduct disorder on the time from first substance use to substance use disorders using g-estimation. (24821350)
2014
2
Does diagnosis affect the predictive accuracy of risk assessment tools for juvenile offenders: Conduct Disorder and Attention Deficit Hyperactivity Disorder. (25173178)
2014
3
ADHD, Conduct Disorder, Substance Use Disorder, and Nonprescription Stimulant Use. (24776714)
2014
4
Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. (24687270)
2014
5
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia? (23015687)
2013
6
Multiple developmental pathways to conduct disorder: current conceptualizations and clinical implications. (23390429)
2013
7
Subclinical bulimia predicts conduct disorder in middle adolescent girls. (22504864)
2013
8
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
9
Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals. (24011986)
2013
10
The neurobiology of oppositional defiant disorder and conduct disorder: altered functioning in three mental domains. (22800761)
2013
11
Childhood conduct disorder trajectories, prior risk factors and cannabis use at age 16: birth cohort study. (23734913)
2013
12
Aripiprazole in children and adolescents with conduct disorder: a single-center, open-label study. (21993869)
2012
13
Parent-reported attention-deficit hyperactivity disorder and subtypes of conduct disorder as risk factor of recidivism in detained male adolescents. (21420836)
2012
14
The role of conduct disorder in the association between ADHD and alcohol use (disorder). Results from the Netherlands Mental Health Survey and Incidence Study-2. (22118715)
2012
15
Annual research review: phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology. (22211395)
2012
16
Adolescent-onset alcohol abuse exacerbates the influence of childhood conduct disorder on late adolescent and early adult antisocial behaviour. (23459369)
2011
17
Identification of attention-deficit-hyperactivity disorder and conduct disorder in Mexican children by the scale for evaluation of deficit of attention and hyperactivity. (20934222)
2011
18
Migration from Mexico to the United States and conduct disorder: a cross-national study. (22147845)
2011
19
The impact of ADHD and conduct disorder in childhood on adult delinquency: a 30 years follow-up study using official crime records. (21481227)
2011
20
Symptoms of conduct disorder, oppositional defiant disorder, attention-deficit/hyperactivity disorder, and callous-unemotional traits as unique predictors of psychosocial maladjustment in boys: advancing an evidence base for DSM-V. (20970701)
2010
21
Neuroanatomical correlates of attention-deficit-hyperactivity disorder accounting for comorbid oppositional defiant disorder and conduct disorder. (20546170)
2010
22
Dimensions of oppositional defiant disorder as predictors of depression and conduct disorder in preadolescent girls. (20431468)
2010
23
Impact of behavioral/developmental disorders comorbid with conduct disorder. (20021630)
2009
24
Effectiveness of lithium in children and adolescents with conduct disorder: a retrospective naturalistic study. (19062775)
2009
25
Service use patterns for adolescents with ADHD and comorbid conduct disorder. (18618263)
2009
26
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. (18413706)
2008
27
Conduct disorder in girls: neighborhoods, family characteristics, and parenting behaviors. (18837974)
2008
28
Early experience with racial discrimination and conduct disorder as predictors of subsequent drug use: a critical period hypothesis. (17275213)
2007
29
Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression. (17705899)
2007
30
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
31
Conduct disorder and antisocial personality disorder in persons with severe psychiatric and substance use disorders. (16574783)
2006
32
Potential mediators of cognitive-behavioral therapy for adolescents with comorbid major depression and conduct disorder. (15709830)
2005
33
The effect of childhood conduct disorder and cognitive functioning on adolescent substance use. (15337863)
2004
34
Reduced temporal lobe volume in early onset conduct disorder. (15546698)
2004
35
Genetic and environmental effects on conduct disorder and alcohol dependence symptoms and their covariation at age 14. (15597087)
2004
36
Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. (12733762)
2003
37
The relationship of conduct disorder to attempted suicide and drug use history among methadone maintenance patients. (12745355)
2003
38
The Maudsley long-term follow-up of child and adolescent depression: 3. Impact of comorbid conduct disorder on service use and costs in adulthood. (11772846)
2002
39
Decreased cortisol levels in adolescent girls with conduct disorder. (11231837)
2001
40
Childhood and adolescent onset conduct disorder: a test of the developmental taxonomy. (11523836)
2001
41
A double-blind placebo-controlled study of lithium in hospitalized aggressive children and adolescents with conduct disorder. (10891035)
2000
42
Conduct: Disorder in children and adolescents (21348167)
2000
43
Cognitive and familial contributions to conduct disorder in children. (10784080)
2000
44
Symptoms of posttraumatic stress disorder in adolescents with conduct disorder: sex differences and onset patterns. (11086558)
2000
45
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
46
Conduct disorder, antisocial personality disorder and substance use disorders in schizophrenia and major affective disorders. (10091967)
1999
47
Individual traits and family contexts predict sons' externalizing behavior and preliminary relative risk ratios for conduct disorder and substance use disorder outcomes. (10482403)
1999
48
Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. (10550498)
1999
49
Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. (10402507)
1999
50
Disruptive behavior, peer association, and conduct disorder: testing the developmental links through early intervention. (16506535)
1999

Variations for Conduct Disorder

About this section

Expression for genes affiliated with Conduct Disorder

About this section
Expression patterns in normal tissues for genes affiliated with Conduct Disorder

Search GEO for disease gene expression data for Conduct Disorder.

Pathways for genes affiliated with Conduct Disorder

About this section

Pathways related to Conduct Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MAOA, COMT
2
Show member pathways
9.7MAOA, COMT
39.7MAOA, COMT
49.7DRD2, DRD4
59.5SLC6A4, MAOA
6
Show member pathways
9.4DRD2, DRD5, DRD4
7
Show member pathways
9.4DRD2, DRD5, DRD4
89.4DRD4, DRD5, DRD2
9
Show member pathways
9.3COMT, MAOA, SLC6A3
10
Show member pathways
9.3MAOA, DRD2, SLC6A3
11
Show member pathways
catecholamine biosynthesis37
9.2MAOA, COMT, DBH
129.2DBH, COMT, MAOA
13
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.2DBH, COMT, MAOA
14
Show member pathways
Serotonin Transporter Activity37
8.6DBH, MAOA, SLC6A4, SLC6A3
15
Show member pathways
7.7SLC6A3, SLC6A4, DRD2, DRD5, DRD4, MAOA

Compounds for genes affiliated with Conduct Disorder

About this section

Compounds related to Conduct Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol44 2810.7DRD4, DRD2, DRD5
2benzamide2 4410.4MAOA, DRD4, DRD2
3rotigotine28 44 1111.4DRD4, DRD5, DRD2
4alpha-methyl-p-tyrosine449.4DBH, SLC6A3, DRD2
5ropinirole44 1110.4DRD2, DRD5, COMT, DRD4
6p-chloroamphetamine449.4SLC6A3, MAOA, SLC6A4
7pergolide44 28 1111.4DRD5, DRD2, DRD4, COMT
8carbon-11449.4MAOA, SLC6A4, SLC6A3
9cabergoline44 28 1111.3DRD5, COMT, DRD4, DRD2
10phentermine44 1110.3SLC6A3, SLC6A4, MAOA
11minaprine44 1110.2DRD2, MAOA, SLC6A4
12pseudoephedrine44 24 1111.1MAOA, SLC6A4, SLC6A3
13pramipexole44 28 50 1112.1SLC6A3, DRD2, DRD4, COMT, DRD5
14d amphetamine449.1MAOA, DRD2, SLC6A3, SLC6A4
15fluvoxamine44 50 1111.1COMT, SLC6A4, SLC6A3, MAOA
16apomorphine28 44 1111.1COMT, DRD4, DRD5, DRD2, SLC6A3
17raclopride44 2810.0SLC6A3, DRD2, DRD4
18bromocriptine44 28 1111.0SLC6A3, DRD2, DRD5, DRD4, COMT
19catecholamine448.9COMT, MAOA, DBH, DRD4, DRD5
20homovanillic acid44 249.9MAOA, COMT, DBH, SLC6A4
21bupropion50 44 24 1111.9DRD2, COMT, SLC6A3, SLC6A4
22fluoxetine44 50 28 1111.9SLC6A3, MAOA, DRD2, SLC6A4
23paroxetine44 50 28 1111.8SLC6A3, COMT, MAOA, SLC6A4, DRD4
24quetiapine44 50 28 24 1112.8SLC6A4, DRD2, DRD5, DRD4, SLC6A3
25haloperidol44 50 28 2 1112.8SLC6A4, DRD4, DRD5, SLC6A3, DRD2
26imipramine44 28 50 24 1112.8DBH, SLC6A4, SLC6A3, MAOA
27amphetamine44 50 1110.8MAOA, DRD4, DRD2, SLC6A4, SLC6A3
28heroin44 50 1110.7DRD2, SLC6A4, SLC6A3, DRD4, COMT
29mhpg448.7SLC6A4, DRD4, DBH, COMT, MAOA
30risperidone44 50 28 61 24 1113.7SLC6A4, COMT, DRD4, DRD2, SLC6A3
31carbon448.7SLC6A3, SLC6A4, TTF2, MAOA, COMT
32tyramine44 28 2410.6COMT, SLC6A4, SLC6A3, MAOA, DBH
33choline44 24 1110.5SLC6A4, SLC6A3, DBH, MAOA, COMT
346-hydroxydopamine448.5MAOA, DBH, DRD4, DRD2, SLC6A3, COMT
35olanzapine44 50 28 24 1112.5SLC6A3, DRD2, DRD5, DRD4, COMT, SLC6A4
36clozapine44 28 50 1111.4DRD4, DRD2, SLC6A4, SLC6A3, COMT, DRD5
37methamphetamine44 50 1110.4SLC6A3, SLC6A4, DRD4, DRD2, COMT, MAOA
38opiate448.4SLC6A3, DRD2, SLC6A4, DBH
39levodopa44 119.2SLC6A3, COMT, MAOA, DRD4, DRD5, DRD2
40gaba448.2SLC6A4, DRD2, DRD4, MAOA, DBH, SLC6A3
41cocaine44 119.2SLC6A3, DRD2, DBH, COMT, SLC6A4, DRD4
42epinephrine44 24 1110.2DRD4, MAOA, DRD2, DBH, COMT, SLC6A4
43mptp448.2DBH, SLC6A4, SLC6A3, DRD2, MAOA, COMT
44methylphenidate44 50 1110.1COMT, MAOA, DRD4, DRD5, SLC6A4, SLC6A3
45maoa447.9COMT, MAOA, DRD4, DRD2, SLC6A4, SLC6A3
465-hydroxytryptamine447.9SLC6A3, SLC6A4, DRD2, DBH, MAOA, DRD4
47glutamate447.7MAOA, DRD4, COMT, DBH, SLC6A4, DRD2
48norepinephrine44 24 119.6DRD4, MAOA, DRD5, SLC6A3, DBH, COMT
49dopamine44 28 24 1110.6DRD5, DRD2, SLC6A4, DRD4, MAOA, DBH
50nicotine44 28 50 1110.6DRD4, SLC6A4, DRD2, COMT, DBH, TTF2

GO Terms for genes affiliated with Conduct Disorder

About this section

Cellular components related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.4SLC6A3, SLC6A4, DRD2, DRD5, DRD4

Biological processes related to Conduct Disorder according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:04205310.1SLC6A3, DRD4
2response to histamineGO:03477610.1DRD4, DRD2
3positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.1DRD2, DRD4
4negative regulation of voltage-gated calcium channel activityGO:190138610.1DRD4, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD4, DRD2
6neurotransmitter catabolic processGO:04213510.1COMT, MAOA
7phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.0DRD2, DRD5
8fear responseGO:04259610.0DBH, DRD4
9dopamine metabolic processGO:04241710.0DRD4, DRD2
10negative regulation of protein secretionGO:05070910.0DRD2, DRD4
11behavioral response to cocaineGO:04814810.0DRD4, DRD2
12adenohypophysis developmentGO:02198410.0DRD2, SLC6A3
13arachidonic acid secretionGO:05048210.0DRD4, DRD2
14associative learningGO:0083069.9DRD2, DRD5
15response to iron ionGO:0100399.9DRD2, SLC6A3
16prepulse inhibitionGO:0601349.9SLC6A3, DRD2
17negative regulation of adenylate cyclase activityGO:0071949.9DRD4, DRD2
18negative regulation of blood pressureGO:0457769.9DRD5, DRD2
19synaptic transmission, dopaminergicGO:0019639.8DRD2, DRD5, DRD4
20monoamine transportGO:0158449.8SLC6A3, SLC6A4
21response to nicotineGO:0350949.8SLC6A3, DRD2
22cellular calcium ion homeostasisGO:0068749.8DRD2, DRD5, DRD4
23response to painGO:0482659.8COMT, DBH
24response to cocaineGO:0422209.8SLC6A3, DRD2, DRD5
25neurotransmitter biosynthetic processGO:0421369.7SLC6A3, MAOA, COMT
26positive regulation of multicellular organism growthGO:0400189.7SLC6A3, DRD2
27behavioral response to ethanolGO:0481499.6DBH, DRD4, DRD2
28social behaviorGO:0351769.6SLC6A4, DRD4
29locomotory behaviorGO:0076269.5DBH, DRD2, SLC6A3
30visual learningGO:0085429.4DBH, DRD2
31memoryGO:0076139.3SLC6A4, DBH
32response to amphetamineGO:0019759.3DRD2, DRD5, DRD4, DBH
33circadian rhythmGO:0076239.3SLC6A4, DRD4
34dopamine catabolic processGO:0424209.2SLC6A3, MAOA, COMT, DBH
35response to drugGO:0424939.0COMT, DRD2, SLC6A4, SLC6A3
36synaptic transmissionGO:0072688.9DBH, COMT, MAOA, DRD5, SLC6A3

Molecular functions related to Conduct Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:0049529.9DRD5, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.8DRD2, DRD4
3potassium channel regulator activityGO:0154599.7DRD2, DRD4
4drug bindingGO:0081449.2DRD2, DRD4, SLC6A3
5monoamine transmembrane transporter activityGO:0085049.2SLC6A3, SLC6A4
6dopamine bindingGO:0352409.2DRD4, DRD5, DRD2, SLC6A3

Products for genes affiliated with Conduct Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Conduct Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet