CAH
MCID: CNG368
MIFTS: 72

Congenital Adrenal Hyperplasia (CAH) malady

Genetic diseases, Rare diseases, Metabolic diseases, Endocrine diseases categories

Summaries for Congenital Adrenal Hyperplasia

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Disease Ontology:9 A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency.

MalaCards based summary: Congenital Adrenal Hyperplasia, also known as lipoid congenital adrenal hyperplasia, is related to pseudohermaphroditism and precocious puberty, and has symptoms including cryptorchidism, hypertension and hypercortisolism. An important gene associated with Congenital Adrenal Hyperplasia is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Estrone metabolism and superpathway of steroid hormone biosynthesis. The drugs hydrocortisone and hydrocortisone probutate and the compounds pcbs and 11b,17a,21-Trihydroxypreg-nenolone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, bone and ovary, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:64 Congenital adrenal hyperplasia (CAH) are any of several autosomal recessive diseases resulting from... more...

Descriptions from OMIM:46 201710,201910,202010,201810,202110

Aliases & Classifications for Congenital Adrenal Hyperplasia

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Congenital Adrenal Hyperplasia, Aliases & Descriptions:

Name: Congenital Adrenal Hyperplasia 9 42 21 23 61
Lipoid Congenital Adrenal Hyperplasia 42 44 61
Congenital Lipoid Adrenal Hyperplasia 9 42
Adrenal Hyperplasia 1 9 61
Lipoid Cah 9 42
 
Congenital Adrenal Hyperplasia Lipoid 42
Adrenal Hyperplasia Congenital 44
Chronic Active Hepatitis 61
Cah 42


Classifications:



External Ids:

Disease Ontology9 DOID:0050811
ICD9CM28 255.2

Related Diseases for Congenital Adrenal Hyperplasia

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Diseases in the Congenital Adrenal Hyperplasia family:

Late-Onset Congenital Adrenal Hyperplasia

Diseases related to Congenital Adrenal Hyperplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1pseudohermaphroditism31.2CYP17A1, HSD3B2
2precocious puberty31.1CYP11B1, CYP21A2
3cytochrome p450 oxidoreductase deficiency30.9POR
4hypertension30.8CYP17A1, CYP11B1, CYP11B2
5lipoid adrenal hyperplasia30.8STAR
6infertility30.7STAR, CYP21A2, CYP11A1
7congenital adrenal insufficiency30.7STAR, CYP11A1
8antley-bixler syndrome30.6CYP17A1, CYP21A2, POR
9leydig cell tumor30.4CYP17A1, CYP11A1, CYP21A2, STAR
10hyperandrogenism30.3CYP17A1, CYP11A1, CYP21A2, HSD3B2
11cushing's syndrome30.2CYP11B2, CYP11B1, CYP21A2
12hypokalemia30.2CYP11B2, CYP17A1
13polycystic ovary syndrome30.0CYP17A1, CYP11A1, CYP21A2, STAR
14obesity29.9CYP11A1, CYP21A2, STAR
15adrenal adenoma29.6CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
16adenoma29.6CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, POR
1721-hydroxylase deficiency11.3
18late-onset congenital adrenal hyperplasia10.9
1911-beta-hydroxylase deficiency10.9
20adrenal rest tumor10.7
213-beta-hydroxysteroid dehydrogenase deficiency10.5
22classic congenital lipoid adrenal hyperplasia due to star deficency10.5
23non-classic congenital lipoid adrenal hyperplasia due to star deficency10.5
24pseudohypoaldosteronism10.5
2517-alpha-hydroxylase deficiency10.5
26male infertility10.4
27congenital hypothyroidism10.4
28hypothyroidism10.4
29central precocious puberty10.4
3011-beta-hydroxylase-deficient congenital adrenal hyperplasia10.4
31disordered steroidogenesis due to cytochrome p450 oxidoreductase10.4
32low renin hypertension10.3CYP11B2
33acne10.3
34hepatitis10.3
35amenorrhea10.3
36anorexia nervosa10.3
37germinoma10.3
38ehlers-danlos syndrome10.3
39meningioma10.3
40ovarian disease10.3
41porphyria10.3
42prostatitis10.3
43turner syndrome10.3
44congenital adrenal hyperplasia due to apparent combined p450c17 and p450c21 deficiency10.3
4517-alpha-hydroxylase-deficient congenital adrenal hyperplasia10.3
46cholesterol desmolase-deficient congenital adrenal hyperplasia10.3
473-beta-hydroxysteroid dehydrogenase-deficient congenital adrenal hyperplasia10.3
48insulin resistance10.3
49classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form10.3
50classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form10.3

Graphical network of the top 20 diseases related to Congenital Adrenal Hyperplasia:



Diseases related to congenital adrenal hyperplasia

Symptoms for Congenital Adrenal Hyperplasia

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Clinical features from OMIM:

201710,201910,202010,201810,202110

HPO human phenotypes related to Congenital Adrenal Hyperplasia:

(show all 7)
id Description Frequency HPO Source Accession
1 cryptorchidism hallmark (90%) HP:0000028
2 hypertension hallmark (90%) HP:0000822
3 hypercortisolism hallmark (90%) HP:0001578
4 abnormality of metabolism/homeostasis hallmark (90%) HP:0001939
5 accelerated skeletal maturation hallmark (90%) HP:0005616
6 female pseudohermaphroditism hallmark (90%) HP:0010458
7 displacement of the external urethral meatus hallmark (90%) HP:0100627

Drugs & Therapeutics for Congenital Adrenal Hyperplasia

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Genetic Tests for Congenital Adrenal Hyperplasia

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Genetic tests related to Congenital Adrenal Hyperplasia:

id Genetic test Affiliating Genes
1 Congenital Adrenal Hyperplasia21 23

Anatomical Context for Congenital Adrenal Hyperplasia

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MalaCards organs/tissues related to Congenital Adrenal Hyperplasia:

32
Adrenal gland, Bone, Ovary, Pituitary, Testes, Prostate, Testis, Liver, Thyroid, Amygdala

Animal Models for Congenital Adrenal Hyperplasia or affiliated genes

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MGI Mouse Phenotypes related to Congenital Adrenal Hyperplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.9CYP11B2, CYP11B1, CYP11A1, STAR
2MP:00053897.9STAR, POR, CYP11A1, CYP17A1, CYP11B1
3MP:00053787.8STAR, POR, CYP11A1, CYP11B1, CYP11B2
4MP:00053767.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, POR, STAR

Publications for Congenital Adrenal Hyperplasia

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Articles related to Congenital Adrenal Hyperplasia:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Increased Cross-Gender Identification Independent of Gender Role Behavior in Girls with Congenital Adrenal Hyperplasia: Results from a Standardized Assessment of 4- to 11-Year-Old Children. (25239661)
2014
2
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. (24834391)
2014
3
The role of imaging in congenital adrenal hyperplasia. (25372578)
2014
4
Congenital adrenal hyperplasia, ovarian failure and Ehlers-Danlos syndrome due to a 6p deletion. (24970489)
2014
5
Increased Prevalence of Testicular Adrenal Rest Tumours during Adolescence in Congenital Adrenal Hyperplasia. (25195868)
2014
6
Mineralocorticoid replacement during infancy for salt wasting congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (23525308)
2013
7
Vaginal bleeding leading to incidental diagnosis of ovarian torsion in an infant with 21 hydroxylase deficiency congenital adrenal hyperplasia. (23040792)
2013
8
Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia. (23211577)
2013
9
Anorexia nervosa in a patient with congenital adrenal hyperplasia. (23382307)
2013
10
A case of androgen-secreting adrenal carcinoma with non-classical congenital adrenal hyperplasia. (24251173)
2013
11
Androgens concentrations and second-to fourth-digit ratio (2D:4D) in girls with congenital adrenal hyperplasia (21-hydroxylase deficiency). (23391972)
2012
12
Non-classical congenital adrenal hyperplasia in association with porphyria cutanea tarda: co-incidence or trigger? (22783026)
2012
13
A sequence variation in 3'UTR of CYP21A2 gene correlates with a mild form of congenital adrenal hyperplasia. (21521936)
2012
14
A case of recurrent labial adhesions in a 15-month-old child with asymptomatic non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (23426836)
2012
15
Health problems in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (21597280)
2011
16
Relationships of basal level of serum 17-hydroxyprogesterone with that of serum androstenedione and their stimulated responses to a low dose of ACTH in young adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (22065901)
2011
17
Quantitation of 17-OH-progesterone (OHPG) for diagnosis of congenital adrenal hyperplasia (CAH). (20077078)
2010
18
Mutational characterization of steroid 21-hydroxylase gene in Portuguese patients with congenital adrenal hyperplasia. (19856253)
2010
19
High frequency of Q318X mutation in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency in northeast Brazil. (19347184)
2009
20
Rare mutations in the CYP21A2 gene detected in congenital adrenal hyperplasia. (19501079)
2009
21
Comparative study of prednisolone versus hydrocortisone acetate for treatment of patients with the classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency]. (18345402)
2008
22
In Sicilian ethnic group non-classical congenital adrenal hyperplasia is frequently associated with a very mild genotype. (17505149)
2007
23
Cognitive outcome in adult women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (16508325)
2006
24
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency. (16551734)
2006
25
Evaluating the accuracy of Malformations Surveillance Program in detecting virilization due to congenital adrenal hyperplasia. (15737123)
2005
26
Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (15483094)
2005
27
Steroid profiling by tandem mass spectrometry improves the positive predictive value of newborn screening for congenital adrenal hyperplasia. (15292289)
2004
28
Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (15514016)
2004
29
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency--the adult woman. (15135781)
2004
30
A novel nonsense mutation in the Cyp11B1 gene from a subject with the steroid 11beta-hydroxylase form of congenital adrenal hyperplasia. (14682466)
2003
31
Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency. (12428206)
2002
32
NIH conference. Future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (11848730)
2002
33
High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. (11739428)
2001
34
Public health explores expanding newborn screening for cystic fibrosis, congenital adrenal hyperplasia, and medium-chain acyl coenzyme A dehydrogenase deficiency (MCAD). (11392180)
2001
35
Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis. (11148508)
2001
36
Antenatal diagnosis and treatment of congenital adrenal hyperplasia. (12084289)
2001
37
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1. (11095433)
2000
38
Influence of different genotypes on 17-hydroxyprogesterone levels in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (10792340)
2000
39
Long-term follow-up of female patients with congenital adrenal hyperplasia from 21-hydroxylase deficiency, with special emphasis on the results of vaginoplasty. (10930925)
2000
40
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia. (10487675)
1999
41
CT findings in congenital adrenal hyperplasia due to 11 beta hydroxylase deficiency at puberty age. (11155857)
1999
42
Growth pattern during the first 36 months of life in congenital adrenal hyperplasia (21-hydroxylase deficiency). (9010713)
1997
43
Identification of non-amplifying CYP21 genes when using PCR-based diagnosis of 21-hydroxylase deficiency in congenital adrenal hyperplasia (CAH) affected pedigrees. (8968761)
1996
44
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. (7584692)
1995
45
Successful prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (7957400)
1994
46
Serum 3 alpha-androstanediol glucuronide measurements in children with congenital adrenal hyperplasia. (7952161)
1994
47
Prenatal diagnosis of 21-hydroxylase deficiency congenital adrenal hyperplasia using the polymerase chain reaction. (1349559)
1992
48
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia. (6602548)
1983
49
No linkage between HLA and congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency. (6601238)
1983
50
Adult manifestation of congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency mimicking polycystic ovarian disease. (6254362)
1980

Variations for Congenital Adrenal Hyperplasia

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Expression for genes affiliated with Congenital Adrenal Hyperplasia

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Expression patterns in normal tissues for genes affiliated with Congenital Adrenal Hyperplasia

Search GEO for disease gene expression data for Congenital Adrenal Hyperplasia.

Pathways for genes affiliated with Congenital Adrenal Hyperplasia

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Pathways related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis59
Androstenedione and testosterone biosynthesis and metabolism p.159
9.1HSD3B2, CYP17A1, CYP11B1
2
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.0CYP11B2, CYP11B1, CYP17A1
38.2STAR, HSD3B2, CYP11A1, CYP17A1
48.0CYP11B1, CYP11A1, CYP21A2, HSD3B2, STAR
5
Show member pathways
7.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
6
Show member pathways
7.4CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, POR
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
7.3CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2
8
Show member pathways
6.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2
9
Show member pathways
6.8STAR, CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2

Compounds for genes affiliated with Congenital Adrenal Hyperplasia

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Compounds related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1pcbs449.4CYP11B1, CYP11B2, CYP21A2
211b,17a,21-Trihydroxypreg-nenolone259.3HSD3B2, CYP11B2, CYP11B1
3cortisone44 2510.2CYP11B1, CYP11B2, CYP21A2
4aldosterone29 25 1211.1CYP11B2, CYP11B1, CYP17A1
5spironolactone44 60 29 50 1213.1CYP11B1, CYP11B2, CYP21A2
6acth 1-24449.1CYP17A1, CYP11A1, CYP21A2
7metyrapone44 60 1211.1CYP21A2, POR, CYP11B1, CYP11B2
817-hydroxypregnenolone449.1CYP17A1, POR, HSD3B2, CYP21A2
911beta-Hydroxyprogesterone259.0CYP11B1, CYP21A2, CYP17A1, CYP11B2
1011b-Hydroxyprogesterone259.0CYP11B2, CYP11B1, CYP21A2, CYP17A1
1121-deoxycortisol44 2510.0CYP21A2, CYP11B1, CYP17A1, CYP11B2
1217a,21-Dihydroxypreg-nenolone259.0HSD3B2, CYP21A2, CYP11B1, CYP11B2
13metoclopramide44 50 1211.0CYP11B2, CYP11B1, CYP17A1
14Cortexolone259.0CYP11B1, HSD3B2, CYP21A2, CYP11B2
15deoxycorticosterone29 2510.0CYP11B2, CYP11B1, CYP21A2, HSD3B2
16pcb 126449.0CYP11B1, CYP21A2, CYP11B2, CYP17A1
17cortisol29 2510.0CYP11B1, HSD3B2, CYP21A2, CYP11B2
18aminopyrine449.0POR, CYP17A1, CYP11A1
1911 deoxycortisol449.0CYP11B2, CYP21A2, CYP17A1, CYP11B1
20ketoconazole44 29 25 1211.7CYP17A1, CYP11A1, CYP21A2, CYP11B1
2117a-Hydroxypregnenolone258.7HSD3B2, CYP21A2, CYP11A1, CYP17A1
22Pregnenolone25 129.7CYP17A1, CYP11A1, HSD3B2, CYP21A2
23dehydroepiandrosterone sulfate448.6CYP11A1, HSD3B2, CYP21A2, CYP17A1
24NADP258.4CYP17A1, CYP21A2, HSD3B2, POR
25dbc-amp448.3CYP17A1, CYP11A1, CYP11B2, STAR
26nifedipine44 29 50 1211.2POR, CYP11A1, CYP17A1, CYP11B2
27doca448.2CYP21A2, CYP11A1, CYP11B1, CYP11B2, CYP17A1
28estradiol44 25 1210.2CYP11B1, CYP17A1, CYP11A1, CYP21A2, STAR
29dihydrotestosterone44 29 25 1211.2POR, CYP17A1, CYP11A1, CYP21A2, HSD3B2
30nadph44 259.1HSD3B2, CYP11A1, CYP21A2, CYP17A1, POR
31sterol448.1STAR, CYP11B2, CYP11A1, CYP17A1
32heme29 25 129.8CYP11A1, CYP21A2, CYP11B2, CYP11B1, CYP17A1, POR
33corticosterone44 60 259.8CYP11B1, CYP11B2, CYP17A1, CYP11A1, CYP21A2, STAR
3411beta-hydroxysteroid447.7CYP17A1, HSD3B2, CYP21A2, CYP11A1, CYP11B1, CYP11B2
35ribonucleic acid447.7CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2, STAR
36estrogen447.6STAR, POR, HSD3B2, CYP11A1, CYP21A2, CYP17A1
3717beta-hydroxysteroid447.6CYP11A1, CYP11B2, CYP21A2, HSD3B2, STAR, CYP17A1
38cyclic amp44 258.6CYP11B2, STAR, CYP11B1, CYP17A1, CYP11A1
3917-hydroxyprogesterone44 258.3POR, CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
40dexamethasone44 50 29 1210.3CYP11B1, CYP11B2, CYP17A1, CYP21A2, POR, STAR
41oxygen44 258.3STAR, CYP11B1, CYP11B2, CYP17A1, POR, CYP21A2
42acth447.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, STAR
43dhea447.2CYP11B2, CYP11A1, CYP17A1, CYP21A2, STAR, POR
44forskolin44 50 129.2STAR, HSD3B2, CYP21A2, CYP11A1, CYP17A1, CYP11B1
45progesterone44 29 60 25 1211.2CYP21A2, CYP17A1, STAR, HSD3B2, CYP11A1, CYP11B1
46cholesterol44 29 25 1210.2STAR, HSD3B2, CYP21A2, CYP11A1, CYP11B1, CYP17A1
473beta-hydroxysteroid446.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2
48androstenedione44 257.8CYP11B2, CYP11B1, CYP17A1, STAR, CYP21A2, HSD3B2
49testosterone44 60 25 129.8POR, CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2
50steroid446.8POR, CYP11B2, HSD3B2, CYP21A2, CYP11A1, CYP17A1

GO Terms for genes affiliated with Congenital Adrenal Hyperplasia

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Cellular components related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial intermembrane spaceGO:0057589.5STAR, HSD3B2
2mitochondrial cristaGO:0300619.3STAR, CYP11A1
3mitochondrial inner membraneGO:0057438.7HSD3B2, CYP11B1, CYP11B2
4endoplasmic reticulum membraneGO:0057898.6CYP17A1, CYP21A2, HSD3B2, POR
5mitochondrionGO:0057397.7POR, CYP11A1, CYP17A1, CYP11B1, CYP11B2

Biological processes related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of steroid hormone biosynthetic processGO:0900319.9POR, CYP17A1
2aldosterone biosynthetic processGO:0323429.8CYP11B1, CYP11B2
3cortisol biosynthetic processGO:0346519.8CYP11B1, CYP11B2
4cellular response to potassium ionGO:0358659.8CYP11B1, CYP11B2
5response to herbicideGO:0096359.8STAR, CYP17A1
6androgen biosynthetic processGO:0067029.7CYP17A1, HSD3B2
7cellular response to hormone stimulusGO:0328709.7CYP11B1, CYP11B2
8response to nutrientGO:0075849.6STAR, POR
9fractalkine metabolic processGO:0507569.6STAR, CYP11A1
10testosterone biosynthetic processGO:0613709.5STAR, CYP11A1
11cellular response to peptide hormone stimulusGO:0713759.5POR, CYP11A1
12progesterone biosynthetic processGO:0067019.5CYP11A1, STAR
13estrogen biosynthetic processGO:0067039.5STAR, CYP11A1
14response to insecticideGO:0170859.5CYP11A1, CYP17A1
15cellular response to cadmium ionGO:0712769.4STAR, CYP11A1
16cellular response to fibroblast growth factor stimulusGO:0443449.4CYP11A1, STAR
17response to corticosteroneGO:0514129.4STAR, CYP11A1
18response to ionizing radiationGO:0102129.4STAR, CYP17A1
19Leydig cell differentiationGO:0333279.4CYP11A1, CYP17A1
20steroid biosynthetic processGO:0066949.4CYP17A1, HSD3B2, STAR
21cellular response to transforming growth factor beta stimulusGO:0715609.3CYP11A1, STAR
22response to hydrogen peroxideGO:0425429.3STAR, CYP11A1
23hippocampus developmentGO:0217669.2CYP11A1, CYP17A1
24cellular response to cAMPGO:0713209.2CYP11A1, STAR
25cellular response to follicle-stimulating hormone stimulusGO:0713729.2CYP11A1, POR, STAR
26glucocorticoid biosynthetic processGO:0067049.1HSD3B2, CYP21A2, CYP17A1, CYP11B1
27response to fungicideGO:0609929.1CYP17A1, CYP11A1, STAR
28dibenzo-p-dioxin metabolic processGO:0188949.1CYP17A1, CYP11A1, STAR
29biphenyl metabolic processGO:0188799.1CYP17A1, CYP11A1, STAR
30phthalate metabolic processGO:0189639.1CYP17A1, CYP11A1, STAR
31phenol-containing compound metabolic processGO:0189589.1CYP17A1, CYP11A1, STAR
32cellular response to antibioticGO:0712369.1STAR, CYP11A1, CYP17A1
33mineralocorticoid biosynthetic processGO:0067059.0HSD3B2, CYP21A2, CYP11B1, CYP11B2
34cellular response to lipopolysaccharideGO:0712229.0CYP17A1, CYP11A1, STAR
35cholesterol metabolic processGO:0082038.9STAR, CYP11A1
36C21-steroid hormone biosynthetic processGO:0067008.6CYP11B2, CYP11B1, CYP11A1, STAR
37response to drugGO:0424938.6CYP17A1, CYP11A1, POR, STAR
38sterol metabolic processGO:0161258.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
39xenobiotic metabolic processGO:0068058.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
40steroid metabolic processGO:0082027.2STAR, HSD3B2, CYP21A2, CYP11A1, CYP17A1, CYP11B1
41small molecule metabolic processGO:0442817.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2

Molecular functions related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.2STAR, CYP11A1
2steroid 11-beta-monooxygenase activityGO:0045079.2CYP11B1, CYP11B2
3heme bindingGO:0200377.7CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
4iron ion bindingGO:0055067.4POR, CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2

Products for genes affiliated with Congenital Adrenal Hyperplasia

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Sources for Congenital Adrenal Hyperplasia

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4CDC
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26ICD10
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40NDF-RT
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