CAH
MCID: CNG368
MIFTS: 66

Congenital Adrenal Hyperplasia (CAH) malady

Genetic diseases, Rare diseases, Endocrine diseases categories
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Summaries for Congenital Adrenal Hyperplasia

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency.

MalaCards: Congenital Adrenal Hyperplasia, also known as congenital lipoid adrenal hyperplasia, is related to pseudohermaphroditism and hypertension. An important gene associated with Congenital Adrenal Hyperplasia is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Estrone metabolism and superpathway of steroid hormone biosynthesis. The drugs hydrocortisone and hydrocortisone probutate and the compounds pcbs and 11b,17a,21-Trihydroxypreg-nenolone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, bone and pituitary, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:65 Congenital adrenal hyperplasia (CAH) are any of several autosomal recessive diseases resulting from... more...

Description from OMIM:47 201710

Aliases & Classifications for Congenital Adrenal Hyperplasia

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8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 45Novoseek, 47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

congenital adrenal hyperplasia 8 43 20 22
congenital lipoid adrenal hyperplasia 8 43
lipoid congenital adrenal hyperplasia 43 45
lipoid cah 8 43
congenital adrenal hyperplasia lipoid 43
adrenal hyperplasia congenital 45
adrenal hyperplasia 1 8
cah 43


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Disease Ontology8 DOID:0050811
OMIM47 201710

Related Diseases for Congenital Adrenal Hyperplasia

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Adrenal Hyperplasia family:

Late-Onset Congenital Adrenal Hyperplasia

Diseases related to Congenital Adrenal Hyperplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1pseudohermaphroditism31.0CYP17A1, HSD3B2
2hypertension30.8CYP17A1, CYP11B1, CYP11B2
3infertility30.8STAR, CYP21A2, CYP11A1
4precocious puberty30.8CYP11B1, CYP21A2
5leydig cell tumor30.6CYP17A1, CYP11A1, CYP21A2, STAR
6hyperandrogenism30.6CYP17A1, CYP11A1, CYP21A2, HSD3B2
7congenital adrenal insufficiency30.6STAR, CYP11A1
8antley-bixler syndrome30.5CYP17A1, CYP21A2, POR
9adenoma30.4CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, POR
10cytochrome p450 oxidoreductase deficiency30.3POR
11lipoid adrenal hyperplasia30.3STAR
12polycystic ovary syndrome30.3CYP17A1, CYP11A1, CYP21A2, STAR
13obesity30.3CYP11A1, CYP21A2, STAR
14adrenal adenoma30.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
15cushing's syndrome30.2CYP11B2, CYP11B1, CYP21A2
16hypokalemia30.2CYP11B2, CYP17A1
1721-hydroxylase deficiency11.3
18late-onset congenital adrenal hyperplasia10.9
1911-beta-hydroxylase deficiency10.8
20adrenal rest tumor10.6
21pseudohypoaldosteronism10.5
2217-alpha-hydroxylase deficiency10.5
233-beta-hydroxysteroid dehydrogenase deficiency10.5
24classic congenital lipoid adrenal hyperplasia due to star deficency10.5
25non-classic congenital lipoid adrenal hyperplasia due to star deficency10.5
26congenital hypothyroidism10.4
27hypothyroidism10.4
28male infertility10.4
29disordered steroidogenesis due to cytochrome p450 oxidoreductase10.4
30central precocious puberty10.4
3111-beta-hydroxylase-deficient congenital adrenal hyperplasia10.4
32cholesterol desmolase-deficient congenital adrenal hyperplasia10.4
33anorexia nervosa10.3
34amenorrhea10.3
35acne10.3
36hepatitis10.3
37meningioma10.3
38ovarian disease10.3
39porphyria10.3
40prostatitis10.3
41turner syndrome10.3
42germinoma10.3
43congenital stationary night blindness, type 1f10.3
44congenital adrenal hyperplasia due to apparent combined p450c17 and p450c21 deficiency10.3
4517-alpha-hydroxylase-deficient congenital adrenal hyperplasia10.3
463-beta-hydroxysteroid dehydrogenase-deficient congenital adrenal hyperplasia10.3
47insulin resistance10.3
48classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form10.3
49classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form10.3
50cystic fibrosis10.1

Graphical network of the top 20 diseases related to Congenital Adrenal Hyperplasia:



Diseases related to congenital adrenal hyperplasia

Symptoms for Congenital Adrenal Hyperplasia

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47OMIM
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Clinical features from OMIM:

201710

Drugs & Therapeutics for Congenital Adrenal Hyperplasia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Congenital Adrenal Hyperplasia

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20GeneTests, 22GTR
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Genetic tests related to Congenital Adrenal Hyperplasia:

id Genetic test Affiliating Genes
1 Congenital Adrenal Hyperplasia20 22

Anatomical Context for Congenital Adrenal Hyperplasia

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33MalaCards
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MalaCards organs/tissues related to Congenital Adrenal Hyperplasia:

33
Adrenal gland, Bone, Pituitary, Testes, Ovary, Testis, Prostate, Liver, Thyroid, Amygdala

Animal Models for Congenital Adrenal Hyperplasia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Congenital Adrenal Hyperplasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.9CYP11B2, CYP11B1, CYP11A1, STAR
2MP:00053897.9STAR, POR, CYP11A1, CYP17A1, CYP11B1
3MP:00053787.8CYP11A1, CYP11B1, CYP11B2, STAR, POR
4MP:00053767.2POR, CYP11A1, CYP17A1, CYP11B1, STAR, CYP11B2

Publications for Congenital Adrenal Hyperplasia

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52PubMed
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Articles related to Congenital Adrenal Hyperplasia:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
Mineralocorticoid replacement during infancy for salt wasting congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (23525308)
2013
2
Vaginal bleeding leading to incidental diagnosis of ovarian torsion in an infant with 21 hydroxylase deficiency congenital adrenal hyperplasia. (23040792)
2013
3
Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia. (23211577)
2013
4
Anorexia nervosa in a patient with congenital adrenal hyperplasia. (23382307)
2013
5
A case of androgen-secreting adrenal carcinoma with non-classical congenital adrenal hyperplasia. (24251173)
2013
6
Androgens concentrations and second-to fourth-digit ratio (2D:4D) in girls with congenital adrenal hyperplasia (21-hydroxylase deficiency). (23391972)
2012
7
Non-classical congenital adrenal hyperplasia in association with porphyria cutanea tarda: co-incidence or trigger? (22783026)
2012
8
A sequence variation in 3'UTR of CYP21A2 gene correlates with a mild form of congenital adrenal hyperplasia. (21521936)
2012
9
A case of recurrent labial adhesions in a 15-month-old child with asymptomatic non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (23426836)
2012
10
Health problems in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (21597280)
2011
11
Relationships of basal level of serum 17-hydroxyprogesterone with that of serum androstenedione and their stimulated responses to a low dose of ACTH in young adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (22065901)
2011
12
Quantitation of 17-OH-progesterone (OHPG) for diagnosis of congenital adrenal hyperplasia (CAH). (20077078)
2010
13
Mutational characterization of steroid 21-hydroxylase gene in Portuguese patients with congenital adrenal hyperplasia. (19856253)
2010
14
High frequency of Q318X mutation in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency in northeast Brazil. (19347184)
2009
15
Rare mutations in the CYP21A2 gene detected in congenital adrenal hyperplasia. (19501079)
2009
16
Comparative study of prednisolone versus hydrocortisone acetate for treatment of patients with the classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency]. (18345402)
2008
17
In Sicilian ethnic group non-classical congenital adrenal hyperplasia is frequently associated with a very mild genotype. (17505149)
2007
18
Effects of adrenal steroids on the bone metabolism of children with congenital adrenal hyperplasia. (18056052)
2007
19
Cognitive outcome in adult women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (16508325)
2006
20
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency. (16551734)
2006
21
Evaluating the accuracy of Malformations Surveillance Program in detecting virilization due to congenital adrenal hyperplasia. (15737123)
2005
22
Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (15483094)
2005
23
Steroid profiling by tandem mass spectrometry improves the positive predictive value of newborn screening for congenital adrenal hyperplasia. (15292289)
2004
24
Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (15514016)
2004
25
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency--the adult woman. (15135781)
2004
26
Normal bone mineral content in young adults with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (14676461)
2004
27
A novel nonsense mutation in the Cyp11B1 gene from a subject with the steroid 11beta-hydroxylase form of congenital adrenal hyperplasia. (14682466)
2003
28
Follow-up of 68 children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: relevance of genotype for management. (12788866)
2003
29
Blood pressure in children and adolescents with congenital adrenal hyperplasia (21-hydroxylase deficiency): a preliminary report. (12699440)
2003
30
Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency. (12428206)
2002
31
NIH conference. Future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (11848730)
2002
32
High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. (11739428)
2001
33
Public health explores expanding newborn screening for cystic fibrosis, congenital adrenal hyperplasia, and medium-chain acyl coenzyme A dehydrogenase deficiency (MCAD). (11392180)
2001
34
Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis. (11148508)
2001
35
Antenatal diagnosis and treatment of congenital adrenal hyperplasia. (12084289)
2001
36
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1. (11095433)
2000
37
Influence of different genotypes on 17-hydroxyprogesterone levels in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (10792340)
2000
38
Long-term follow-up of female patients with congenital adrenal hyperplasia from 21-hydroxylase deficiency, with special emphasis on the results of vaginoplasty. (10930925)
2000
39
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia. (10487675)
1999
40
CT findings in congenital adrenal hyperplasia due to 11 beta hydroxylase deficiency at puberty age. (11155857)
1999
41
Growth pattern during the first 36 months of life in congenital adrenal hyperplasia (21-hydroxylase deficiency). (9010713)
1997
42
Identification of non-amplifying CYP21 genes when using PCR-based diagnosis of 21-hydroxylase deficiency in congenital adrenal hyperplasia (CAH) affected pedigrees. (8968761)
1996
43
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. (7584692)
1995
44
Successful prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (7957400)
1994
45
Serum 3 alpha-androstanediol glucuronide measurements in children with congenital adrenal hyperplasia. (7952161)
1994
46
Ovarian suppression reduces clinical and endocrine expression of late-onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (7926082)
1994
47
Prenatal diagnosis of 21-hydroxylase deficiency congenital adrenal hyperplasia using the polymerase chain reaction. (1349559)
1992
48
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia. (6602548)
1983
49
No linkage between HLA and congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency. (6601238)
1983
50
Adult manifestation of congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency mimicking polycystic ovarian disease. (6254362)
1980

Variations for Congenital Adrenal Hyperplasia

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Expression for genes affiliated with Congenital Adrenal Hyperplasia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Adrenal Hyperplasia

Search GEO for disease gene expression data for Congenital Adrenal Hyperplasia.

Pathways for genes affiliated with Congenital Adrenal Hyperplasia

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 51PharmGKB
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Pathways related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.1CYP17A1, HSD3B2, CYP11B1
2
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
9.0CYP17A1, CYP11B1, CYP11B2
38.2CYP17A1, STAR, HSD3B2, CYP11A1
48.0CYP21A2, CYP11A1, CYP11B1, HSD3B2, STAR
5
Show member pathways
7.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
6
Show member pathways
7.4CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2, POR
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
7.3CYP11B1, CYP11B2, CYP17A1, HSD3B2, CYP11A1, CYP21A2
8
Show member pathways
6.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2
9
Show member pathways
6.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2

Compounds for genes affiliated with Congenital Adrenal Hyperplasia

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45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1pcbs459.4CYP11B1, CYP11B2, CYP21A2
211b,17a,21-Trihydroxypreg-nenolone249.3HSD3B2, CYP11B2, CYP11B1
3cortisone45 2410.2CYP11B1, CYP11B2, CYP21A2
4aldosterone29 24 1111.1CYP11B2, CYP11B1, CYP17A1
5spironolactone45 61 29 51 1113.1CYP11B1, CYP11B2, CYP21A2
6acth 1-24459.1CYP17A1, CYP11A1, CYP21A2
7metyrapone45 61 1111.1CYP21A2, POR, CYP11B1, CYP11B2
817-hydroxypregnenolone459.1CYP17A1, POR, HSD3B2, CYP21A2
911beta-Hydroxyprogesterone249.0CYP11B1, CYP21A2, CYP17A1, CYP11B2
1011b-Hydroxyprogesterone249.0CYP11B2, CYP11B1, CYP21A2, CYP17A1
1121-deoxycortisol45 2410.0CYP21A2, CYP11B1, CYP17A1, CYP11B2
1217a,21-Dihydroxypreg-nenolone249.0HSD3B2, CYP21A2, CYP11B1, CYP11B2
13metoclopramide45 51 1111.0CYP11B2, CYP11B1, CYP17A1
14Cortexolone249.0CYP11B1, HSD3B2, CYP21A2, CYP11B2
15deoxycorticosterone29 2410.0CYP11B2, CYP11B1, CYP21A2, HSD3B2
16pcb 126459.0CYP11B1, CYP21A2, CYP11B2, CYP17A1
17cortisol29 2410.0CYP11B1, HSD3B2, CYP21A2, CYP11B2
18aminopyrine459.0POR, CYP17A1, CYP11A1
1911 deoxycortisol459.0CYP11B2, CYP21A2, CYP17A1, CYP11B1
20ketoconazole45 29 24 1111.7CYP17A1, CYP11A1, CYP21A2, CYP11B1
2117a-Hydroxypregnenolone248.7HSD3B2, CYP21A2, CYP11A1, CYP17A1
22Pregnenolone24 119.7CYP17A1, CYP11A1, HSD3B2, CYP21A2
23dehydroepiandrosterone sulfate458.6CYP11A1, HSD3B2, CYP21A2, CYP17A1
24NADP248.4CYP17A1, CYP21A2, HSD3B2, POR
25dbc-amp458.3CYP17A1, CYP11A1, CYP11B2, STAR
26nifedipine45 29 51 1111.2POR, CYP11A1, CYP17A1, CYP11B2
27doca458.2CYP21A2, CYP11A1, CYP11B1, CYP11B2, CYP17A1
28estradiol45 24 1110.2CYP11B1, CYP17A1, CYP11A1, CYP21A2, STAR
29dihydrotestosterone45 29 24 1111.2POR, CYP17A1, CYP11A1, CYP21A2, HSD3B2
30nadph45 249.1HSD3B2, CYP11A1, CYP21A2, CYP17A1, POR
31sterol458.1STAR, CYP11B2, CYP11A1, CYP17A1
32heme29 24 119.8CYP11A1, CYP21A2, CYP11B2, CYP11B1, CYP17A1, POR
33corticosterone45 61 249.8CYP11B1, CYP11B2, CYP17A1, CYP11A1, CYP21A2, STAR
3411beta-hydroxysteroid457.7CYP17A1, HSD3B2, CYP21A2, CYP11A1, CYP11B1, CYP11B2
35ribonucleic acid457.7CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2, STAR
36estrogen457.6STAR, POR, HSD3B2, CYP11A1, CYP21A2, CYP17A1
3717beta-hydroxysteroid457.6CYP11A1, CYP11B2, CYP21A2, HSD3B2, STAR, CYP17A1
38cyclic amp45 248.6CYP11B2, STAR, CYP11B1, CYP17A1, CYP11A1
3917-hydroxyprogesterone45 248.3POR, CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
40dexamethasone45 51 29 1110.3CYP11B1, CYP11B2, CYP17A1, CYP21A2, POR, STAR
41oxygen45 248.3STAR, CYP11B1, CYP11B2, CYP17A1, POR, CYP21A2
42acth457.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, STAR
43dhea457.2CYP11B2, CYP11A1, CYP17A1, CYP21A2, STAR, POR
44forskolin45 51 119.2STAR, HSD3B2, CYP21A2, CYP11A1, CYP17A1, CYP11B1
45progesterone45 29 61 24 1111.2CYP21A2, CYP17A1, STAR, HSD3B2, CYP11A1, CYP11B1
46cholesterol45 29 24 1110.2STAR, HSD3B2, CYP21A2, CYP11A1, CYP11B1, CYP17A1
473beta-hydroxysteroid456.8CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2
48androstenedione45 247.8CYP11B2, CYP11B1, CYP17A1, STAR, CYP21A2, HSD3B2
49testosterone45 61 24 119.8POR, CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2
50steroid456.8POR, CYP11B2, HSD3B2, CYP21A2, CYP11A1, CYP17A1

GO Terms for genes affiliated with Congenital Adrenal Hyperplasia

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16Gene Ontology
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Cellular components related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial intermembrane spaceGO:0057589.5STAR, HSD3B2
2mitochondrial cristaGO:0300619.3STAR, CYP11A1
3mitochondrial inner membraneGO:0057438.7HSD3B2, CYP11B1, CYP11B2
4endoplasmic reticulum membraneGO:0057898.6CYP17A1, CYP21A2, HSD3B2, POR
5mitochondrionGO:0057397.7POR, CYP11A1, CYP17A1, CYP11B1, CYP11B2

Biological processes related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of steroid hormone biosynthetic processGO:0900319.9POR, CYP17A1
2aldosterone biosynthetic processGO:0323429.8CYP11B1, CYP11B2
3cortisol biosynthetic processGO:0346519.8CYP11B1, CYP11B2
4cellular response to potassium ionGO:0358659.8CYP11B1, CYP11B2
5response to herbicideGO:0096359.8STAR, CYP17A1
6androgen biosynthetic processGO:0067029.7CYP17A1, HSD3B2
7cellular response to hormone stimulusGO:0328709.7CYP11B1, CYP11B2
8response to nutrientGO:0075849.6STAR, POR
9fractalkine metabolic processGO:0507569.6STAR, CYP11A1
10testosterone biosynthetic processGO:0613709.5STAR, CYP11A1
11cellular response to peptide hormone stimulusGO:0713759.5POR, CYP11A1
12progesterone biosynthetic processGO:0067019.5CYP11A1, STAR
13estrogen biosynthetic processGO:0067039.5STAR, CYP11A1
14response to insecticideGO:0170859.5CYP11A1, CYP17A1
15cellular response to cadmium ionGO:0712769.4STAR, CYP11A1
16cellular response to fibroblast growth factor stimulusGO:0443449.4CYP11A1, STAR
17response to corticosteroneGO:0514129.4STAR, CYP11A1
18response to ionizing radiationGO:0102129.4STAR, CYP17A1
19Leydig cell differentiationGO:0333279.4CYP11A1, CYP17A1
20steroid biosynthetic processGO:0066949.4CYP17A1, HSD3B2, STAR
21cellular response to transforming growth factor beta stimulusGO:0715609.3CYP11A1, STAR
22response to hydrogen peroxideGO:0425429.3STAR, CYP11A1
23hippocampus developmentGO:0217669.2CYP11A1, CYP17A1
24cellular response to cAMPGO:0713209.2CYP11A1, STAR
25cellular response to follicle-stimulating hormone stimulusGO:0713729.2CYP11A1, POR, STAR
26glucocorticoid biosynthetic processGO:0067049.1HSD3B2, CYP21A2, CYP17A1, CYP11B1
27response to fungicideGO:0609929.1CYP17A1, CYP11A1, STAR
28dibenzo-p-dioxin metabolic processGO:0188949.1CYP17A1, CYP11A1, STAR
29biphenyl metabolic processGO:0188799.1CYP17A1, CYP11A1, STAR
30phthalate metabolic processGO:0189639.1CYP17A1, CYP11A1, STAR
31phenol-containing compound metabolic processGO:0189589.1CYP17A1, CYP11A1, STAR
32cellular response to antibioticGO:0712369.1STAR, CYP11A1, CYP17A1
33mineralocorticoid biosynthetic processGO:0067059.0HSD3B2, CYP21A2, CYP11B1, CYP11B2
34cellular response to lipopolysaccharideGO:0712229.0CYP17A1, CYP11A1, STAR
35cholesterol metabolic processGO:0082038.9STAR, CYP11A1
36C21-steroid hormone biosynthetic processGO:0067008.6CYP11B2, CYP11B1, CYP11A1, STAR
37response to drugGO:0424938.6CYP17A1, CYP11A1, POR, STAR
38sterol metabolic processGO:0161258.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
39xenobiotic metabolic processGO:0068058.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
40steroid metabolic processGO:0082027.2STAR, HSD3B2, CYP21A2, CYP11A1, CYP17A1, CYP11B1
41small molecule metabolic processGO:0442817.2CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2, HSD3B2

Molecular functions related to Congenital Adrenal Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.2STAR, CYP11A1
2steroid 11-beta-monooxygenase activityGO:0045079.2CYP11B1, CYP11B2
3heme bindingGO:0200377.7CYP11B2, CYP11B1, CYP17A1, CYP11A1, CYP21A2
4iron ion bindingGO:0055067.4POR, CYP21A2, CYP11A1, CYP17A1, CYP11B1, CYP11B2

Products for genes affiliated with Congenital Adrenal Hyperplasia

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Sources for Congenital Adrenal Hyperplasia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet