MCID: CNG069
MIFTS: 36

Congenital Cytomegalovirus malady

Rare diseases category
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Summaries for Congenital Cytomegalovirus

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33MalaCards
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MalaCards: Congenital Cytomegalovirus is related to sensorineural hearing loss and enlarged vestibular aqueduct. An important gene associated with Congenital Cytomegalovirus is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways are Gap junction trafficking and Signaling in Gap Junctions. The compounds carbenoxolone disodium and scrambled 10panx have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and fetal brain.

Aliases & Classifications for Congenital Cytomegalovirus

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43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

congenital cytomegalovirus 43


Related Diseases for Congenital Cytomegalovirus

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17GeneCards, 18GeneDecks
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Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1sensorineural hearing loss30.8GJB6, GJB2
2enlarged vestibular aqueduct30.0GJB6, GJB2
3hepatitis29.8GPT, CD40LG
4cytomegalovirus infection11.2
5cerebritis10.3
6chorioretinitis10.2
7retinitis10.2
8cytomegalovirus retinitis10.2
9ectodermal dysplasia10.1GJB2
10cholecystitis10.1GPT
11hydrocephalus10.1
12hypertension10.1
13labyrinthitis10.1
14oligohydramnios10.1
15pneumonia10.1
16neonatal herpes10.1
17fetal cytomegalovirus syndrome10.1
18viral hepatitis10.1GPT
19bart-pumphrey syndrome10.1GJB6, GJB2
20dfnb 1 nonsyndromic hearing loss and deafness10.1GJB6, GJB2
21dfna 3 nonsyndromic hearing loss and deafness10.1GJB6, GJB2
22hemorrhagic fever10.1CD40LG
23hidrotic ectodermal dysplasia 210.0GJB6, GJB2
24dfnb110.0GJB6, GJB2
25clouston syndrome10.0GJB6, GJB2
26nonsyndromic deafness10.0GJB2, GJB6
27hepatitis e10.0GPT, CD40LG
28scrub typhus10.0GPT, CD40LG
29autoimmune hepatitis10.0CD40LG, GPT
30skin disease10.0GJB6, GJB2
31primary biliary cirrhosis10.0CD40LG, GPT
32hepatitis c10.0CD40LG, GPT
33thrombocytopenia10.0CD40LG, GPT
34diabetes insipidus9.9
35neuronitis9.9
36microcephaly9.9
37microphthalmia9.9
38acquired immunodeficiency syndrome9.9
39parotitis9.9
40horner's syndrome9.9
41hydranencephaly9.9
42leukemoid reaction9.9
43twin-to-twin transfusion syndrome9.9
44autistic disorder9.9
45wiskott-aldrich syndrome9.9
46systemic lupus erythematosus9.9
47periventricular leukomalacia9.9
48communicating hydrocephalus9.9
49dilated cardiomyopathy9.9
50disseminated intravascular coagulation9.9

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to congenital cytomegalovirus

Symptoms for Congenital Cytomegalovirus

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Drugs & Therapeutics for Congenital Cytomegalovirus

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Congenital Cytomegalovirus

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

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Anatomical Context for Congenital Cytomegalovirus

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33MalaCards
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MalaCards organs/tissues related to Congenital Cytomegalovirus:

33
Brain, Testes, Fetal brain, Liver, Lung, Placenta, Bone marrow, Breast, Thyroid, Spinal cord, Bone, Temporal lobe

Animal Models for Congenital Cytomegalovirus or affiliated genes

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Publications for Congenital Cytomegalovirus

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52PubMed
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Articles related to Congenital Cytomegalovirus:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Congenital cytomegalovirus is the second most frequent cause of bilateral hearing loss in young French children. (23022111)
2013
2
Newborn screening of congenital cytomegalovirus infection using saliva can be influenced by breast feeding. (22874907)
2013
3
Congenital cytomegalovirus infection and finger anomaly. (23761501)
2013
4
Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger? (23025246)
2013
5
Neonatal Screening for Congenital Cytomegalovirus Infection in Preterm and Small for Gestational Age Infants. (24328547)
2013
6
The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. (23559569)
2013
7
Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease. (22605840)
2012
8
A trial of immunoglobulin fetal therapy for symptomatic congenital cytomegalovirus infection. (22884280)
2012
9
Congenital cytomegalovirus infection following antenatal negative diagnostic amniotic fluid analysis - a single center experience. (22489602)
2012
10
A rare case of congenital cytomegalovirus infection in pregnancy. (23372295)
2012
11
Life-threatening intracranial bleeding in a newborn with congenital cytomegalovirus infection: late-onset neonatal hemorrhagic disease. (21083361)
2011
12
Valganciclovir treatment in a 6-month-old infant with asymptomatic congenital cytomegalovirus infection and late hearing loss. (22105427)
2011
13
Outcome of cochlear implantation in asymptomatic congenital cytomegalovirus deafened children. (21792969)
2011
14
Malformations of cortical development in children with congenital cytomegalovirus infection - A study of nine children with proven congenital cytomegalovirus infection. (21648339)
2011
15
Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord. (20837611)
2011
16
Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection. (21597906)
2011
17
Congenital cytomegalovirus infection: treatment, sequelae and follow-up. (20807160)
2010
18
Congenital cytomegalovirus infection. (20840266)
2010
19
Congenital cytomegalovirus infection associated with severe lung involvement in a preterm neonate: a causal relationship? (19224246)
2009
20
Newborn screening for congenital cytomegalovirus: Options for hospital-based and public health programs. (19783205)
2009
21
Rehabilitation and outcome of severe profound deafness in a group of 16 infants affected by congenital cytomegalovirus infection. (19283400)
2009
22
Microphthalmia and microcornea: in congenital cytomegalovirus. (19574708)
2009
23
Retrospective diagnosis of congenital cytomegalovirus infection at a school for the deaf by using preserved dried umbilical cord. (19840618)
2009
24
Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. (19317969)
2009
25
A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection. (19389443)
2009
26
A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. (18571542)
2008
27
Late onset of ultrasound abnormalities in a case of periconceptional congenital cytomegalovirus infection. (18383478)
2008
28
Recent advances in the prevention and treatment of congenital cytomegalovirus infections. (17317422)
2007
29
Nonprimate models of congenital cytomegalovirus (CMV) infection: gaining insight into pathogenesis and prevention of disease in newborns. (16391432)
2006
30
Screening for congenital cytomegalovirus infection: a tapestry of controversies. (15689898)
2005
31
Congenital cytomegalovirus infection and its prevention. (15034840)
2004
32
Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection. (15566332)
2004
33
Birth characteristics and growth pattern in children with congenital cytomegalovirus infection. (14714744)
2003
34
Congenital cytomegalovirus infection in twin pregnancies: viral load in the amniotic fluid and pregnancy outcome. (12897321)
2003
35
Congenital Cytomegalovirus Infection. (11931729)
2002
36
Congenital cytomegalovirus infection in a northern Italian region. NEOCMV Group. (9928874)
1998
37
Congenital cytomegalovirus infection presenting as severe persistent pulmonary hypertension of the newborn. (9659657)
1998
38
Schizencephaly and congenital cytomegalovirus infection. (9763793)
1998
39
Clinical survey of congenital cytomegalovirus infection in Japan. (9821701)
1998
40
Diagnosis of congenital cytomegalovirus infection by examination of placenta: application of polymerase chain reaction and in situ hybridization. (9086531)
1997
41
Immunization strategy for prevention of congenital cytomegalovirus infection. (8884369)
1996
42
Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary CMV infection in the guinea pig model. (7594656)
1995
43
Congenital cytomegalovirus infection in Shimla Hills, Himachal Pradesh, India. (7636148)
1995
44
Congenital cytomegalovirus infection: a case report. (8169681)
1994
45
Prenatal diagnosis of 52 pregnancies at risk for congenital cytomegalovirus infection. (8397357)
1993
46
Congenital cytomegalovirus infection in Korean population with very high prevalence of maternal immunity. (1329845)
1992
47
Prenatal diagnosis of congenital cytomegalovirus infection by virus isolation from amniotic fluid. (2171339)
1990
48
Congenital cytomegalovirus infection associated with fetal ascites and intrahepatic calcifications. (2557722)
1989
49
Cyclopia and congenital cytomegalovirus infection. (2823607)
1987
50
Congenital cytomegalovirus infection and maternal systemic lupus erythematosus: a case report. (3022760)
1986

Variations for Congenital Cytomegalovirus

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Expression for genes affiliated with Congenital Cytomegalovirus

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for genes affiliated with Congenital Cytomegalovirus

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50PathCards, 55Reactome, 53QIAGEN, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GJB2, GJB6
2
Show member pathways
9.6GJB2, GJB6
3
Show member pathways
Cytoplasmic Ribosomal Proteins38
9.5MT-RNR1, RNR1

Compounds for genes affiliated with Congenital Cytomegalovirus

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Sources:
61Tocris Bioscience, 29IUPHAR, 24HMDB, 45Novoseek, 11DrugBank, 3BitterDB, 51PharmGKB
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Compounds related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1carbenoxolone disodium6110.0GJB6, GJB2
2scrambled 10panx6110.0GJB2, GJB6
310panx6110.0GJB2, GJB6
4gap 276110.0GJB2, GJB6
5octanol29 2411.0GJB6, GJB2
6carbenoxolone45 29 1112.0GJB2, GJB6
7ca2+2910.0GJB2, GJB6
8flufenamic acid29 45 3 1112.9GJB2, GJB6
9asparagine459.3GJB2, GPT
10ursodeoxycholic acid45 24 1111.3GPT, CD40LG
11valproate459.3CD40LG, GPT
12mycophenolate mofetil45 51 1111.3CD40LG, GPT
13fenofibrate45 51 1111.3GPT, CD40LG
14ivig459.3CD40LG, GPT
15ribavirin45 51 1111.3CD40LG, GPT
16vitamin b12459.2GPT, CD40LG
17neopterin459.2CD40LG, GPT
18pravastatin45 51 29 24 1113.1GPT, CD40LG
19atorvastatin45 51 29 24 1113.0GPT, CD40LG
20hyaluronic acid45 2410.0CD40LG, GPT
21cocaine45 119.9CD40LG, GPT
22aspartate458.9CD40LG, GPT, GJB2
23thyroxine45 249.7CD40LG, GPT

GO Terms for genes affiliated with Congenital Cytomegalovirus

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16Gene Ontology
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Cellular components related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.6GJB2, GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of soundGO:0076059.6GJB2, GJB6

Products for genes affiliated with Congenital Cytomegalovirus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Cytomegalovirus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet