MCID: CNG069
MIFTS: 36

Congenital Cytomegalovirus malady

Rare diseases category
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Summaries for Congenital Cytomegalovirus

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MalaCards based summary: Congenital Cytomegalovirus is related to sensorineural hearing loss and enlarged vestibular aqueduct. An important gene associated with Congenital Cytomegalovirus is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways are Gap junction trafficking and Signaling in Gap Junctions. The compounds 10panx and gap 27 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and liver.

Aliases & Classifications for Congenital Cytomegalovirus

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Congenital Cytomegalovirus, Aliases & Descriptions:

Name: Congenital Cytomegalovirus 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Congenital Cytomegalovirus

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Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1sensorineural hearing loss31.0GJB6, GJB2
2enlarged vestibular aqueduct30.2GJB6, GJB2
3hepatitis29.7CD40LG, GPT
4cytomegalovirus infection11.3
5ectodermal dysplasia10.4GJB2
6cerebritis10.4
7cholecystitis10.4GPT
8viral hepatitis10.3GPT
9dfna 3 nonsyndromic hearing loss and deafness10.2GJB2, GJB6
10dfnb 1 nonsyndromic hearing loss and deafness10.2GJB2, GJB6
11bart-pumphrey syndrome10.2GJB2, GJB6
12hemorrhagic fever10.2CD40LG
13hidrotic ectodermal dysplasia 210.2GJB2, GJB6
14dfnb110.2GJB2, GJB6
15clouston syndrome10.2GJB2, GJB6
16cerebral palsy10.2
17chorioretinitis10.2
18retinitis10.2
19cytomegalovirus retinitis10.2
20nonsyndromic deafness10.1GJB6, GJB2
21hydrocephalus10.1
22hypertension10.1
23pulmonary hypertension10.1
24labyrinthitis10.1
25oligohydramnios10.1
26neonatal herpes10.1
27fetal cytomegalovirus syndrome10.1
28hepatitis e10.0CD40LG, GPT
29scrub typhus10.0GPT, CD40LG
30autoimmune hepatitis10.0CD40LG, GPT
31skin disease9.9GJB2, GJB6
32autistic disorder9.9
33dilated cardiomyopathy9.9
34leukemia9.9
35neutropenia9.9
36systemic lupus erythematosus9.9
37wiskott-aldrich syndrome9.9
38acquired immunodeficiency syndrome9.9
39twin-to-twin transfusion syndrome9.9
40periventricular leukomalacia9.9
41diabetes insipidus9.9
42hydranencephaly9.9
43neuronitis9.9
44microcephaly9.9
45microphthalmia9.9
46parotitis9.9
47horner's syndrome9.9
48leukemoid reaction9.9
49autism spectrum disorder9.9
50communicating hydrocephalus9.9

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to congenital cytomegalovirus

Symptoms for Congenital Cytomegalovirus

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Drugs & Therapeutics for Congenital Cytomegalovirus

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Drug clinical trials:

Search ClinicalTrials for Congenital Cytomegalovirus

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

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Anatomical Context for Congenital Cytomegalovirus

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MalaCards organs/tissues related to Congenital Cytomegalovirus:

32
Brain, Testes, Liver, Lung, Placenta, Fetal brain, Bone marrow, Bone, Spinal cord, Thyroid, Breast, Temporal lobe

Animal Models for Congenital Cytomegalovirus or affiliated genes

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Publications for Congenital Cytomegalovirus

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Articles related to Congenital Cytomegalovirus:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Unusually difficult clinical presentation of an infant suffering from congenital cytomegalovirus (CMV) infection combined with alpha 1-antitrypsin (A1AT) deficiency. (25351359)
2014
2
Clinical features of cerebral palsy in children with symptomatic congenital cytomegalovirus infection. (24931914)
2014
3
Congenital cytomegalovirus: what the otolaryngologist should know. (25222916)
2014
4
Congenital cytomegalovirus infection. (25015493)
2014
5
Congenital cytomegalovirus is the second most frequent cause of bilateral hearing loss in young French children. (23022111)
2013
6
Newborn screening of congenital cytomegalovirus infection using saliva can be influenced by breast feeding. (22874907)
2013
7
Congenital cytomegalovirus infection and finger anomaly. (23761501)
2013
8
Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger? (23025246)
2013
9
Neonatal Screening for Congenital Cytomegalovirus Infection in Preterm and Small for Gestational Age Infants. (24328547)
2013
10
The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. (23559569)
2013
11
Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease. (22605840)
2012
12
A trial of immunoglobulin fetal therapy for symptomatic congenital cytomegalovirus infection. (22884280)
2012
13
Congenital cytomegalovirus infection following antenatal negative diagnostic amniotic fluid analysis - a single center experience. (22489602)
2012
14
A rare case of congenital cytomegalovirus infection in pregnancy. (23372295)
2012
15
Life-threatening intracranial bleeding in a newborn with congenital cytomegalovirus infection: late-onset neonatal hemorrhagic disease. (21083361)
2011
16
Valganciclovir treatment in a 6-month-old infant with asymptomatic congenital cytomegalovirus infection and late hearing loss. (22105427)
2011
17
Outcome of cochlear implantation in asymptomatic congenital cytomegalovirus deafened children. (21792969)
2011
18
Malformations of cortical development in children with congenital cytomegalovirus infection - A study of nine children with proven congenital cytomegalovirus infection. (21648339)
2011
19
Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord. (20837611)
2011
20
Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection. (21597906)
2011
21
Congenital cytomegalovirus infection: treatment, sequelae and follow-up. (20807160)
2010
22
Congenital cytomegalovirus infection. (20840266)
2010
23
Congenital cytomegalovirus infection associated with severe lung involvement in a preterm neonate: a causal relationship? (19224246)
2009
24
Newborn screening for congenital cytomegalovirus: Options for hospital-based and public health programs. (19783205)
2009
25
Rehabilitation and outcome of severe profound deafness in a group of 16 infants affected by congenital cytomegalovirus infection. (19283400)
2009
26
Microphthalmia and microcornea: in congenital cytomegalovirus. (19574708)
2009
27
Retrospective diagnosis of congenital cytomegalovirus infection at a school for the deaf by using preserved dried umbilical cord. (19840618)
2009
28
Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. (19317969)
2009
29
A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. (18571542)
2008
30
Late onset of ultrasound abnormalities in a case of periconceptional congenital cytomegalovirus infection. (18383478)
2008
31
Recent advances in the prevention and treatment of congenital cytomegalovirus infections. (17317422)
2007
32
Nonprimate models of congenital cytomegalovirus (CMV) infection: gaining insight into pathogenesis and prevention of disease in newborns. (16391432)
2006
33
Screening for congenital cytomegalovirus infection: a tapestry of controversies. (15689898)
2005
34
Congenital cytomegalovirus infection and its prevention. (15034840)
2004
35
Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection. (15566332)
2004
36
Birth characteristics and growth pattern in children with congenital cytomegalovirus infection. (14714744)
2003
37
Congenital Cytomegalovirus Infection. (11931729)
2002
38
Congenital cytomegalovirus infection in a northern Italian region. NEOCMV Group. (9928874)
1998
39
Congenital cytomegalovirus infection presenting as severe persistent pulmonary hypertension of the newborn. (9659657)
1998
40
Schizencephaly and congenital cytomegalovirus infection. (9763793)
1998
41
Diagnosis of congenital cytomegalovirus infection by examination of placenta: application of polymerase chain reaction and in situ hybridization. (9086531)
1997
42
Immunization strategy for prevention of congenital cytomegalovirus infection. (8884369)
1996
43
Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary CMV infection in the guinea pig model. (7594656)
1995
44
Congenital cytomegalovirus infection: a case report. (8169681)
1994
45
Prenatal diagnosis of 52 pregnancies at risk for congenital cytomegalovirus infection. (8397357)
1993
46
Congenital cytomegalovirus infection in Korean population with very high prevalence of maternal immunity. (1329845)
1992
47
Prenatal diagnosis of congenital cytomegalovirus infection by virus isolation from amniotic fluid. (2171339)
1990
48
Congenital cytomegalovirus infection associated with fetal ascites and intrahepatic calcifications. (2557722)
1989
49
Cyclopia and congenital cytomegalovirus infection. (2823607)
1987
50
Congenital cytomegalovirus infection and maternal systemic lupus erythematosus: a case report. (3022760)
1986

Variations for Congenital Cytomegalovirus

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Expression for genes affiliated with Congenital Cytomegalovirus

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Expression patterns in normal tissues for genes affiliated with Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for genes affiliated with Congenital Cytomegalovirus

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Pathways related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GJB2, GJB6
2
Show member pathways
9.6GJB2, GJB6
3
Show member pathways
Cytoplasmic Ribosomal Proteins37
9.5MT-RNR1, RNR1

Compounds for genes affiliated with Congenital Cytomegalovirus

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Compounds related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
110panx6110.0GJB2, GJB6
2gap 276110.0GJB6, GJB2
3carbenoxolone disodium6110.0GJB6, GJB2
4scrambled 10panx6110.0GJB6, GJB2
5octanol28 2411.0GJB2, GJB6
6carbenoxolone44 28 1112.0GJB6, GJB2
7ca2+2810.0GJB2, GJB6
8flufenamic acid28 44 2 1112.9GJB2, GJB6
9asparagine449.3GJB2, GPT
10ursodeoxycholic acid44 24 1111.3GPT, CD40LG
11valproate449.3CD40LG, GPT
12mycophenolate mofetil44 50 1111.3CD40LG, GPT
13fenofibrate44 50 1111.3GPT, CD40LG
14ivig449.3CD40LG, GPT
15ribavirin44 50 1111.3CD40LG, GPT
16vitamin b12449.2CD40LG, GPT
17neopterin449.2CD40LG, GPT
18pravastatin44 50 28 24 1113.1GPT, CD40LG
19atorvastatin44 50 28 24 1113.0CD40LG, GPT
20hyaluronic acid44 2410.0CD40LG, GPT
21cocaine44 119.9GPT, CD40LG
22aspartate448.9GPT, GJB2, CD40LG
23thyroxine44 249.7CD40LG, GPT

GO Terms for genes affiliated with Congenital Cytomegalovirus

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Cellular components related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.6GJB2, GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of soundGO:0076059.6GJB2, GJB6

Products for genes affiliated with Congenital Cytomegalovirus

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  • Antibodies
  • Proteins
  • Lysates

Sources for Congenital Cytomegalovirus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet