MCID: CNG069
MIFTS: 33

Congenital Cytomegalovirus malady

Summaries for Congenital Cytomegalovirus

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33MalaCards
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MalaCards: Congenital Cytomegalovirus is related to sensorineural hearing loss and enlarged vestibular aqueduct. An important gene associated with Congenital Cytomegalovirus is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways is Gap junction trafficking. The compounds 10panx and scrambled 10panx have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord.

Aliases & Classifications for Congenital Cytomegalovirus

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

congenital cytomegalovirus 43


Related Diseases for Congenital Cytomegalovirus

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1sensorineural hearing loss30.7GJB6, GJB2
2enlarged vestibular aqueduct29.9GJB2, GJB6
3cytomegalovirus infection11.3
4cytomegalovirus retinitis10.2
5n syndrome10.1
6neonatal herpes10.1
7erythrokeratodermia variabilis10.0GJB2
8cystic fibrosis10.0GJB2
9melanoma10.0GJB2
10palmoplantar keratosis10.0GJB6
11keratoderma10.0GJB2
12usher syndrome10.0GJB2
13cryoglobulinemic vasculitis10.0CD40LG
14cryoglobulinemia10.0CD40LG
15bart-pumphrey syndrome10.0GJB6, GJB2
16dfnb 1 nonsyndromic hearing loss and deafness10.0GJB6, GJB2
17dfna 3 nonsyndromic hearing loss and deafness10.0GJB6, GJB2
18hidrotic ectodermal dysplasia 210.0GJB2, GJB6
19dfnb110.0GJB2, GJB6
20clouston syndrome10.0GJB2, GJB6
21colorectal cancer10.0GJB2, RNASET2
22cholecystitis10.0GPT
23rubella10.0CD40LG
24hyperuricemia10.0GPT
25cholelithiasis10.0GPT
26scrub typhus10.0GPT, CD40LG
27autoimmune hepatitis10.0GPT, CD40LG
28hepatitis e10.0GPT, CD40LG
29primary biliary cirrhosis10.0GPT, CD40LG
30periventricular leukomalacia9.9
31leukemoid reaction9.9
32autistic disorder9.9
33wiskott-aldrich syndrome9.9
34systemic lupus erythematosus9.9
35diabetes insipidus9.9
36thyroid hormone resistance syndrome9.9
37microcephaly9.9
38microphthalmia9.9
39acquired immunodeficiency syndrome9.9
40parotitis9.9
41congenital toxoplasmosis9.9
42horner's syndrome9.9
43hydranencephaly9.9
44toxoplasmosis9.9
45congenital hepatic fibrosis9.9
46corpus callosum agenesis9.9
47pachygyria9.9
48cerebellar hypoplasia9.9
49cytomegalic inclusion disease9.9
50congenital lobar emphysema9.9

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to congenital cytomegalovirus

Clinical Features for Congenital Cytomegalovirus

Drugs & Therapeutics for Congenital Cytomegalovirus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Cytomegalovirus

Drug clinical trials:

Search ClinicalTrials for Congenital Cytomegalovirus

Search NIH Clinical Center for Congenital Cytomegalovirus

Search CenterWatch for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

Sources:
33MalaCards
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MalaCards organs/tissues related to Congenital Cytomegalovirus:

33
Bone marrow, Brain, Spinal cord, Small intestine, Liver, Lung, Thyroid, Breast, Placenta, Nk cells, T cells, B cells, Fetal brain, Temporal lobe, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Congenital Cytomegalovirus or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Congenital Cytomegalovirus

Sources:
51PubMed
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Articles related to Congenital Cytomegalovirus:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Congenital cytomegalovirus infection and finger anomaly. (23761501)
2013
2
Bronchial atresia in a neonate with congenital cytomegalovirus infection. (24250739)
2013
3
NEOREG: design and implementation of an online Neonatal Registration System to access, follow and analyse the data of newborns with congenital cytomegalovirus infection. (23323747)
2013
4
Human fetal inner ear involvement in congenital cytomegalovirus infection. (24252374)
2013
5
A pilot study using residual newborn dried blood spots to assess the potential role of cytomegalovirus and Toxoplasma gondii in the etiology of congenital hydrocephalus. (23716471)
2013
6
A rare case of congenital cytomegalovirus infection in pregnancy. (23372295)
2012
7
Real-time PCR versus viral culture on urine as a gold standard in the diagnosis of congenital cytomegalovirus infection. (22177273)
2012
8
Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children. (22965785)
2012
9
Valganciclovir treatment in a 6-month-old infant with asymptomatic congenital cytomegalovirus infection and late hearing loss. (22105427)
2011
10
Have we overlooked congenital cytomegalovirus infection as a cause of stillbirth? (21592978)
2011
11
Congenital cytomegalovirus infection manifesting as neonatal persistent pulmonary hypertension: report of two cases. (21766016)
2011
12
Teaching NeuroImages: CT scan of congenital cytomegalovirus infection. (21242489)
2011
13
Hearing status in children with congenital cytomegalovirus: up-to-6-years audiological follow-up. (21236499)
2011
14
Congenital cytomegalovirus infection in the Netherlands: birth prevalence and risk factors. (21837795)
2011
15
Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection. (21078944)
2011
16
Use of screening dried blood spots for estimation of prevalence, risk factors, and birth outcomes of congenital cytomegalovirus infection. (20400091)
2010
17
Screening newborns for congenital cytomegalovirus infection. (20388901)
2010
18
Congenital rubella and cytomegalovirus infections in and around Chandigarh. (19136779)
2009
19
Late onset of ultrasound abnormalities in a case of periconceptional congenital cytomegalovirus infection. (18383478)
2008
20
Induction of cytomegalovirus-infected labyrinthitis in newborn mice by lipopolysaccharide: a model for hearing loss in congenital CMV infection. (18475257)
2008
21
Newborn hearing screening and detection of congenital cytomegalovirus infection. (18450901)
2008
22
Vestibular-evoked myogenic potentials and caloric stimulation in infants with congenital cytomegalovirus infection. (17888197)
2008
23
Oral valganciclovir for symptomatic congenital cytomegalovirus infection in an extremely low birth weight infant. (18165832)
2008
24
Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection. (17299708)
2007
25
New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. (17542052)
2007
26
Prospects for development and potential impact of a vaccine against congenital cytomegalovirus (CMV) infection. (18035130)
2007
27
Congenital cytomegalovirus infection associated with corpus callosum agenesis. (17437918)
2007
28
Serum proteomics with SELDI-TOF-MS in congenital human cytomegalovirus hepatitis. (17705191)
2007
29
Etiology of severe sensorineural hearing loss in children: independent impact of congenital cytomegalovirus infection and GJB2 mutations. (17299707)
2007
30
Abnormally expanded pro-B hematogones associated with congenital cytomegalovirus infection. (17617782)
2007
31
Congenital cytomegalovirus infection in pregnancy: a case report of fetal death in a CMV-infected woman. (17333226)
2007
32
Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. (16425139)
2006
33
Diagnosis of human congenital cytomegalovirus infection by amplification of viral DNA from dried blood spots on perinatal cards. (16645211)
2006
34
Congenital cytomegalovirus infection in Israel: screening in different subpopulations. (15847203)
2005
35
Congenital cytomegalovirus infection and its prevention. (15034840)
2004
36
Retrospective diagnosis of congenital cytomegalovirus infection using dried umbilical cords. (15131484)
2004
37
Treatment of children with congenital cytomegalovirus infection with ganciclovir. (12799506)
2003
38
Urine polymerase chain reaction as a screening tool for the detection of congenital cytomegalovirus infection. (12937039)
2003
39
Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. (12915819)
2003
40
Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rate. (11224840)
2001
41
Development and application of a PCR-based method including an internal control for diagnosis of congenital cytomegalovirus infection. (10618053)
2000
42
Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. (9129069)
1997
43
A female infant successfully treated by ganciclovir for congenital cytomegalovirus infection. (7793258)
1995
44
Congenital cytomegalovirus infection with oligohydramnios and echogenic bowel at 14 weeks' gestation. (7474061)
1995
45
Accuracy of amniotic fluid testing before 21 weeks' gestation in prenatal diagnosis of congenital cytomegalovirus infection. (7877953)
1994
46
Symptomatic congenital cytomegalovirus infection after maternal recurrent infection. (8170734)
1994
47
Virus-specific antibody responses in mothers and their newborn infants with asymptomatic congenital cytomegalovirus infections. (8380292)
1993
48
Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. (1331946)
1992
49
Magnetic resonance imaging of the brain in congenital rubella virus and cytomegalovirus infections. (1652704)
1991
50
Congenital cytomegalovirus infection and maternal systemic lupus erythematosus: a case report. (3022760)
1986

Genetic Variations for Congenital Cytomegalovirus

Expression for genes affiliated with Congenital Cytomegalovirus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for genes affiliated with Congenital Cytomegalovirus

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54Reactome
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Pathways related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6GJB2, GJB6

Compounds for genes affiliated with Congenital Cytomegalovirus

Sources:
60Tocris Bioscience, 29IUPHAR, 24HMDB, 45Novoseek, 11DrugBank, 2BitterDB, 50PharmGKB
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Compounds related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
110panx6010.0GJB2, GJB6
2scrambled 10panx6010.0GJB2, GJB6
3carbenoxolone disodium609.9GJB2, GJB6
4gap 27609.9GJB2, GJB6
5octanol29 2410.9GJB6, GJB2
6carbenoxolone29 45 1111.9GJB2, GJB6
7ca2+299.9GJB2, GJB6
8flufenamic acid45 29 2 1112.9GJB6, GJB2
9ursodeoxycholic acid45 11 2411.3GPT, CD40LG
10mycophenolate mofetil45 50 1111.2CD40LG, GPT
11valproate459.2GPT, CD40LG
12fenofibrate45 50 1111.2GPT, CD40LG
13ribavirin45 50 1111.1CD40LG, GPT
14ivig459.1GPT, CD40LG
15vitamin b12459.0CD40LG, GPT
16pravastatin45 50 29 11 2413.0GPT, CD40LG
17neopterin458.9GPT, CD40LG
18aspartate458.4GPT, GJB2, CD40LG

GO Terms for genes affiliated with Congenital Cytomegalovirus

Sources:
16Gene Ontology
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Cellular components related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.6GJB2, GJB6

Products for genes affiliated with Congenital Cytomegalovirus

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  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Cytomegalovirus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet