MCID: CNG069
MIFTS: 40

Congenital Cytomegalovirus

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Congenital Cytomegalovirus

MalaCards integrated aliases for Congenital Cytomegalovirus:

Name: Congenital Cytomegalovirus 49
Congenital Cytomegalovirus Infection 69

Classifications:



External Ids:

ICD10 32 P35.1
UMLS 69 C0158945

Summaries for Congenital Cytomegalovirus

NIH Rare Diseases : 49 Congenital cytomegalovirus (congenital CMV) is a group of symptoms that may occur when an infant is infected with the cytomegalovirus before birth. Most infants who are infected with the virus never develop symptoms of the condition. However, approximately 10% of babies will experience health problems and/or disabilities such as problems with the lungs, liver and/or spleen at birth; hearing loss; vision loss; intellectual disability; seizures; small head size; and/or lack of coordination. Some babies with the condition may have evidence of infection at birth, while others may not develop symptoms for two or more years. Congenital CMV occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta. Treatment is based on the signs and symptoms present in each person. Last updated: 11/4/2015

MalaCards based summary : Congenital Cytomegalovirus, also known as congenital cytomegalovirus infection, is related to deafness, autosomal recessive 4, with enlarged vestibular aqueduct and cytomegalovirus infection. An important gene associated with Congenital Cytomegalovirus is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways is Malaria. The drugs Anti-Infective Agents and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and placenta.

Wikipedia : 72 Congenital cytomegalovirus infection refers to a condition where cytomegalovirus is transmitted in the... more...

Related Diseases for Congenital Cytomegalovirus

Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 29.3 GJB2 GJB6
2 cytomegalovirus infection 10.9
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
4 deafness, autosomal recessive 1b 10.3 GJB2 GJB6
5 deafness, autosomal dominant 24 10.3 GJB2 GJB6
6 deafness, x-linked 2 10.3 GJB2 GJB6
7 kid syndrome 10.3 GJB2 GJB6
8 pseudoainhum 10.2 GJB2 GJB6
9 knuckle pads, leukonychia, and sensorineural deafness 10.2 GJB2 GJB6
10 deafness, autosomal recessive 1a 10.2 GJB2 GJB6
11 dfnb1 10.2 GJB2 GJB6
12 vohwinkel syndrome 10.2 GJB2 GJB6
13 knuckle pads 10.2 GJB2 GJB6
14 non-syndromic genetic deafness 10.2 GJB2 GJB6
15 sensorineural hearing loss 10.2
16 vestibular disease 10.2 GJB2 GJB6
17 deafness, autosomal recessive 16 10.2 GJB2 GJB6
18 deafness, autosomal dominant 2a 10.1 GJB2 GJB6
19 erythrokeratodermia variabilis et progressiva 1 10.1 GJB2 GJB6
20 deafness, autosomal recessive 7 10.1 GJB2 MT-RNR1
21 deafness, autosomal dominant 36 10.1 GJB2 MT-RNR1
22 autosomal dominant non-syndromic sensorineural deafness type dfna 10.1 GJB2 GJB6
23 clouston syndrome 10.0 GJB2 GJB6
24 cerebritis 10.0
25 idiopathic bilateral vestibulopathy 10.0 MT-RNR1 RNR1
26 deafness, autosomal recessive 30 10.0 GJB2 MT-RNR1
27 fetal cytomegalovirus syndrome 10.0
28 aging 9.9
29 corneal disease 9.9 GJB2 GJB6
30 alveolar echinococcosis 9.9 KLRK1 TLR2
31 branchiootic syndrome 1 9.9
32 cerebral palsy 9.9
33 autism 9.8
34 hepatitis 9.8
35 retinitis 9.8
36 chorioretinitis 9.8
37 hodgkin's lymphoma, nodular sclerosis 9.8 GJB2 GJB6 MT-RNR1
38 deafness, autosomal recessive 12 9.8 GJB2 GJB6 MT-RNR1
39 inner ear disease 9.8 GJB2 GJB6 MT-RNR1
40 auditory system disease 9.8 GJB2 GJB6 MT-RNR1
41 autosomal recessive non-syndromic sensorineural deafness type dfnb 9.8 GJB2 GJB6
42 cytomegalovirus retinitis 9.8
43 nonsyndromic deafness 9.7 GJB2 GJB6 MT-RNR1
44 fibrosis of extraocular muscles, congenital, 1 9.7
45 cortical dysplasia, complex, with other brain malformations 7 9.7
46 pulmonary hypertension 9.7
47 twin-to-twin transfusion syndrome 9.7
48 hydrocephalus 9.7
49 autism spectrum disorder 9.7
50 oligohydramnios 9.7

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to Congenital Cytomegalovirus

Symptoms & Phenotypes for Congenital Cytomegalovirus

Drugs & Therapeutics for Congenital Cytomegalovirus

Drugs for Congenital Cytomegalovirus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
2 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Acyclovir Phase 4,Phase 2,Phase 3
4 valacyclovir Phase 4,Phase 2,Phase 3
5
Ganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 82410-32-0 3454
6
Valganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 175865-60-8 64147
7
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
8
Povidone Approved Phase 3 9003-39-8
9 Rho(D) Immune Globulin Phase 3
10 gamma-Globulins Phase 3
11 Ganciclovir triphosphate Phase 3,Phase 2,Phase 1
12 Pharmaceutical Solutions Phase 3,Phase 2
13 Immunoglobulins Phase 3,Phase 1,Phase 2
14 Immunoglobulins, Intravenous Phase 3
15 Antibodies Phase 3,Phase 1,Phase 2
16 Sodium Benzoate Phase 3
17 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
18 MF59 oil emulsion Phase 2
19 Vaccines Phase 2,Phase 1
20 Antibodies, Monoclonal Phase 1, Phase 2
21 Krestin

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir Terminated NCT01037712 Phase 4 Valacyclovir (ZELITREX);Placebo
2 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment Unknown status NCT02005822 Phase 3 Valganciclovir
3 A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections. Completed NCT00001100 Phase 3 ganciclovir
4 Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection Completed NCT00004278 Phase 3 ganciclovir
5 Short-Term vs. Long-Term Valganciclovir Therapy for Symptomatic Congenital CMV Infections Completed NCT00466817 Phase 3 Valganciclovir
6 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
7 Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Recruiting NCT02351102 Phase 2, Phase 3 Valacyclovir;Placebo
8 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Not yet recruiting NCT02606266 Phase 2, Phase 3 Valganciclovir
9 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
10 Randomized Controlled Trial of Valganciclovir for Asymptomatic Cytomegalovirus Infected Hearing Impaired Infants Not yet recruiting NCT03107871 Phase 3 Valganciclovir;Simple Syrup
11 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3 Valganciclovir
12 Valganciclovir in Congenital CMV Infants Completed NCT00031434 Phase 1, Phase 2 Valganciclovir;Ganciclovir
13 Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease Completed NCT00004642 Phase 1, Phase 2 SDZ MSL-109
14 Recombinant CMV gB Vaccine in Postpartum Women Completed NCT00125502 Phase 2 MF59 adjuvant;Placebo
15 Congenital CMV and Hearing Loss in Children up to 4 Years of Age: Treating With Valganciclovir Therapy Recruiting NCT01649869 Phase 2 Valcyte (Valganciclovir hydrochloride) Powder for oral solution;Placebo
16 Asymptomatic Congenital CMV Treatment Not yet recruiting NCT03301415 Phase 2 Valganciclovir
17 Safety, Tolerability, and Immunogenicity of a Cytomegalovirus DNA Vaccine Withdrawn NCT02594566 Phase 1 CyMVectin
18 A Cross-sectional Study of Congenital Cytomegalovirus Infection in Newborns in China Unknown status NCT02710864
19 Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women With Primary Cytomegalovirus Infection Unknown status NCT01659684
20 Genotyping of Cytomegalovirus From Patients in Israel Unknown status NCT00228202
21 The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment Completed NCT01162330
22 Clinical Trial of Behavioral Modification to Prevent Congenital Cytomegalovirus Completed NCT01819519
23 Neonatal CMV-Ganciclovir Follow-up Study Completed NCT00031421
24 Study of the Transmission of Cytomegalovirus (CMV) Infection From Mother to Foetus Completed NCT01251744
25 Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection? Completed NCT00872703
26 Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital CMV Recruiting NCT02782988
27 Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening Recruiting NCT02139423
28 A Cohort Study of Cytomegalovirus(CMV) Infection Among Pregnant Women and Their Newborns in China Recruiting NCT02645396
29 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Recruiting NCT02680743
30 Prognostic Value of Neonatal Markers (Clinical, Imaging and Biological) for the Development of Neurosensorial Sequelae in Children Infected by Cytomegalovirus (CMV) in Utero Recruiting NCT01923636
31 Biomarkers of Cytomegalovirus Fetal Infection and Disease Recruiting NCT03090841
32 Immunological Characteristics of Maternal-fetal Transmission of Cytomegalovirus in Pregnancy Recruiting NCT02129465
33 Relevance of Gastric Aspirate in HCMV Detection Recruiting NCT03262194
34 Screening for Congenital Cytomegalovirus Infection in Newborns Enrolling by invitation NCT02683096
35 Development of Potential Biomarkers for Foetal Brain Development After Congenital CMV Infection Not yet recruiting NCT03188679
36 Cytomegalovirus (CMV) Vaccines: Reinfection and Antigenic Variation Not yet recruiting NCT03443791

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

MalaCards organs/tissues related to Congenital Cytomegalovirus:

38
Liver, Lung, Placenta, Spleen, Brain, Testes, T Cells

Publications for Congenital Cytomegalovirus

Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 641)
# Title Authors Year
1
Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection. ( 29359492 )
2018
2
Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection. ( 29441223 )
2018
3
Congenital Cytomegalovirus Infection: Update on Treatment: Scientific Impact Paper No. 56. ( 29139205 )
2018
4
Healthcare costs attributable to congenital cytomegalovirus infection. ( 29363491 )
2018
5
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
6
Reply to the Letter: "Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection". ( 29443330 )
2018
7
Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections. ( 29343580 )
2018
8
Contribution of Breastfeeding to False Positive Saliva PCR for Newborn Congenital Cytomegalovirus Screening. ( 29401303 )
2018
9
Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Infants Who Fail Newborn Hearing Screening. ( 29373759 )
2018
10
Congenital cytomegalovirus infection in Central Germany: an underestimated risk. ( 28624987 )
2017
11
Neonatal and long-term ophthalmological findings in infants with symptomatic and asymptomatic congenital cytomegalovirus infection. ( 29149633 )
2017
12
T and B Cell Markers in Dried Blood Spots of Neonates with Congenital Cytomegalovirus Infection: B Cell Numbers at Birth Are Associated with Long-Term Outcomes. ( 27903736 )
2017
13
Management and outcomes of cochlear implantation in patients with congenital cytomegalovirus (cCMV)-related deafness. ( 28485697 )
2017
14
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection. ( 27843092 )
2017
15
Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women. ( 27986675 )
2017
16
Pulmonary Calcification in a Congenital Cytomegalovirus Infection. ( 28807358 )
2017
17
Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis. ( 29185167 )
2017
18
Outcomes of congenital cytomegalovirus disease following maternal primary and non-primary infection. ( 28938230 )
2017
19
Hearing and neurodevelopmental outcomes for children with asymptomatic congenital cytomegalovirus infection: A systematic review. ( 28876493 )
2017
20
Congenital Cytomegalovirus Infection: Prognostic Value of Maternal DNAemia at Amniocentesis. ( 27986666 )
2017
21
Congenital cytomegalovirus - who, when, what-with and why to treat? ( 28646968 )
2017
22
Congenital cytomegalovirus and infantile neutropaenia: A causal relationship? ( 28786201 )
2017
23
Preventing Congenital Cytomegalovirus Infection. ( 28825308 )
2017
24
Congenital Cytomegalovirus Infection after a Multiple-Birth Pregnancy. ( 28763424 )
2017
25
High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland. ( 28735326 )
2017
26
Analysis of archived newborn dried blood spots (DBS) identifies congenital cytomegalovirus as a major cause of unexplained pediatric sensorineural hearing loss. ( 28629849 )
2017
27
Congenital Cytomegalovirus Infection: Maternal-Child HLA-C, HLA-E, and HLA-G Affect Clinical Outcome. ( 29354123 )
2017
28
Symptomatic congenital Cytomegalovirus deafness: the impact of a six-week course of antiviral treatment on hearing improvement. ( 29286014 )
2017
29
Intrauterine fetal death due to congenital cytomegalovirus infection. ( 28606416 )
2017
30
Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study. ( 28056855 )
2017
31
Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. ( 28679960 )
2017
32
A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening. ( 28049114 )
2017
33
Neonatal screening parameters in infants with congenital Cytomegalovirus infection. ( 28847685 )
2017
34
Pathogenesis of developmental anomalies of the central nervous system induced by congenital cytomegalovirus infection. ( 28074532 )
2017
35
Hyperimmune globulin in pregnancy for the prevention of congenital cytomegalovirus disease. ( 29072089 )
2017
36
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
37
Symptomatic Congenital Cytomegalovirus Infection in Children of Seropositive Women. ( 28649563 )
2017
38
Long-term Outcomes of Cochlear Implantation in Children With Congenital Cytomegalovirus Infection. ( 28604578 )
2017
39
Congenital Cytomegalovirus: a "Now" Problem-No Really, Now. ( 27795304 )
2017
40
Pulmonary Hypoplasia Caused by Fetal Ascites in Congenital Cytomegalovirus Infection Despite Fetal Therapy. ( 29164089 )
2017
41
Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management. ( 29140947 )
2017
42
Clinical evaluation of the new Roche platform of serological and molecular cytomegalovirus-specific assays in the diagnosis and prognosis of congenital cytomegalovirus infection. ( 28801056 )
2017
43
Sensorineural Hearing Loss in a Patient Affected by Congenital Cytomegalovirus Infection: Is It Useful to Identify Comorbid Pathologies? ( 28794912 )
2017
44
Screening for Congenital Cytomegalovirus Is Recommended in Every Newborn. ( 29151083 )
2017
45
Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss. ( 28501927 )
2017
46
Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection. ( 29066580 )
2017
47
Immune responses to congenital cytomegalovirus infection. ( 29287989 )
2017
48
Detection of congenital cytomegalovirus in newborns using nucleic acid amplification techniques and its public health implications. ( 29116590 )
2017
49
Congenital Cytomegalovirus Infection: Child Development, Quality of Life and Impact on Daily Life. ( 28650934 )
2017
50
Clinical Predictors of Sensorineural Hearing Loss and Cognitive Outcome in Infants with Symptomatic Congenital Cytomegalovirus Infection. ( 27195603 )
2016

Variations for Congenital Cytomegalovirus

Expression for Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for Congenital Cytomegalovirus

Pathways related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.31 KLRK1 TLR2

GO Terms for Congenital Cytomegalovirus

Cellular components related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 GJB2 TLR2
2 gap junction GO:0005921 8.96 GJB2 GJB6
3 connexin complex GO:0005922 8.62 GJB2 GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.58 GJB6 PPARG TLR2
2 defense response to Gram-positive bacterium GO:0050830 9.43 KLRK1 TLR2
3 inner ear development GO:0048839 9.37 GJB2 GJB6
4 cell communication GO:0007154 9.32 GJB2 GJB6
5 response to retinoic acid GO:0032526 9.26 GJB2 PPARG
6 response to progesterone GO:0032570 9.16 GJB2 TLR2
7 response to lipopolysaccharide GO:0032496 9.13 GJB2 GJB6 TLR2
8 positive regulation of oligodendrocyte differentiation GO:0048714 8.62 PPARG TLR2

Sources for Congenital Cytomegalovirus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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