Congenital Cytomegalovirus disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Congenital Cytomegalovirus

MalaCards based summary: Congenital Cytomegalovirus is related to sensorineural hearing loss and enlarged vestibular aqueduct. An important gene associated with Congenital Cytomegalovirus is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways are Gap junction trafficking and Signaling in Gap Junctions. The compounds 10panx and gap 27 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and liver.

Aliases & Classifications for Congenital Cytomegalovirus

Sources:
⁴²NIH Rare Diseases
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Congenital Cytomegalovirus, Aliases & Descriptions:

Name: Congenital Cytomegalovirus ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases

Related Diseases for Congenital Cytomegalovirus

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
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Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 82)

id	Related Disease	Score	Top Affiliating Genes
1	sensorineural hearing loss	31.0	GJB6, GJB2
2	enlarged vestibular aqueduct	30.2	GJB6, GJB2
3	hepatitis	29.7	CD40LG, GPT
4	cytomegalovirus infection	11.3
5	ectodermal dysplasia	10.4	GJB2
6	cerebritis	10.4
7	cholecystitis	10.4	GPT
8	viral hepatitis	10.3	GPT
9	dfna 3 nonsyndromic hearing loss and deafness	10.2	GJB2, GJB6
10	dfnb 1 nonsyndromic hearing loss and deafness	10.2	GJB2, GJB6
11	bart-pumphrey syndrome	10.2	GJB2, GJB6
12	hemorrhagic fever	10.2	CD40LG
13	hidrotic ectodermal dysplasia 2	10.2	GJB2, GJB6
14	dfnb1	10.2	GJB2, GJB6
15	clouston syndrome	10.2	GJB2, GJB6
16	cerebral palsy	10.2
17	chorioretinitis	10.2
18	retinitis	10.2
19	cytomegalovirus retinitis	10.2
20	nonsyndromic deafness	10.1	GJB6, GJB2
21	hydrocephalus	10.1
22	hypertension	10.1
23	pulmonary hypertension	10.1
24	labyrinthitis	10.1
25	oligohydramnios	10.1
26	neonatal herpes	10.1
27	fetal cytomegalovirus syndrome	10.1
28	hepatitis e	10.0	CD40LG, GPT
29	scrub typhus	10.0	GPT, CD40LG
30	autoimmune hepatitis	10.0	CD40LG, GPT
31	skin disease	9.9	GJB2, GJB6
32	autistic disorder	9.9
33	dilated cardiomyopathy	9.9
34	leukemia	9.9
35	neutropenia	9.9
36	systemic lupus erythematosus	9.9
37	wiskott-aldrich syndrome	9.9
38	acquired immunodeficiency syndrome	9.9
39	twin-to-twin transfusion syndrome	9.9
40	periventricular leukomalacia	9.9
41	diabetes insipidus	9.9
42	hydranencephaly	9.9
43	neuronitis	9.9
44	microcephaly	9.9
45	microphthalmia	9.9
46	parotitis	9.9
47	horner's syndrome	9.9
48	leukemoid reaction	9.9
49	autism spectrum disorder	9.9
50	communicating hydrocephalus	9.9

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:

Symptoms for Congenital Cytomegalovirus

Drugs & Therapeutics for Congenital Cytomegalovirus

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Congenital Cytomegalovirus

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

Sources:
³²MalaCards
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MalaCards organs/tissues related to Congenital Cytomegalovirus:

³²

Brain, Testes, Liver, Lung, Placenta, Fetal brain, Bone marrow, Bone, Spinal cord, Thyroid, Breast, Temporal lobe

Animal Models for Congenital Cytomegalovirus or affiliated genes

Publications for Congenital Cytomegalovirus

Sources:
⁵¹PubMed
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Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 510)

id	Title	Authors	Year
1	Unusually difficult clinical presentation of an infant suffering from congenital cytomegalovirus (CMV) infection combined with alpha 1-antitrypsin (A1AT) deficiency. (25351359)	PotoA8njak I.... Zaja O.	2014
2	Clinical features of cerebral palsy in children with symptomatic congenital cytomegalovirus infection. (24931914)	Dakovic I.... Bosnjak V.M.	2014
3	Congenital cytomegalovirus: what the otolaryngologist should know. (25222916)	Duval M.... Park A.H.	2014
4	Congenital cytomegalovirus infection. (25015493)	Bale J.F.	2014
5	Congenital cytomegalovirus is the second most frequent cause of bilateral hearing loss in young French children. (23022111)	Avettand-FenoAl V.... Leruez-Ville M.	2013
6	Newborn screening of congenital cytomegalovirus infection using saliva can be influenced by breast feeding. (22874907)	Koyano S.... Azuma H.	2013
7	Congenital cytomegalovirus infection and finger anomaly. (23761501)	Isikay S.... Yilmaz K.	2013
8	Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger? (23025246)	Iyer A.... Appleton R.	2013
9	Neonatal Screening for Congenital Cytomegalovirus Infection in Preterm and Small for Gestational Age Infants. (24328547)	Lorenzoni F.... Ghirri P.	2013
10	The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. (23559569)	de Vries J.J.... Vossen A.C.	2013
11	Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease. (22605840)	Staunton B.H.... Smith D.	2012
12	A trial of immunoglobulin fetal therapy for symptomatic congenital cytomegalovirus infection. (22884280)		2012
13	Congenital cytomegalovirus infection following antenatal negative diagnostic amniotic fluid analysis - a single center experience. (22489602)	Gabbay-Benziv R.... Pardo J.	2012
14	A rare case of congenital cytomegalovirus infection in pregnancy. (23372295)	Roy S.S.... Sengupta S.	2012
15	Life-threatening intracranial bleeding in a newborn with congenital cytomegalovirus infection: late-onset neonatal hemorrhagic disease. (21083361)	Dallar Y.... Alioglu B.	2011
16	Valganciclovir treatment in a 6-month-old infant with asymptomatic congenital cytomegalovirus infection and late hearing loss. (22105427)	Stronati M.... Lombardi G.	2011
17	Outcome of cochlear implantation in asymptomatic congenital cytomegalovirus deafened children. (21792969)	Malik V.... Ramsden R.T.	2011
18	Malformations of cortical development in children with congenital cytomegalovirus infection - A study of nine children with proven congenital cytomegalovirus infection. (21648339)	Bosnjak V.M.... Marn B.	2011
19	Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord. (20837611)	Ikeno M.... Shimizu T.	2011
20	Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection. (21597906)	Manara R.... Ruga E.M.	2011
21	Congenital cytomegalovirus infection: treatment, sequelae and follow-up. (20807160)	Lombardi G.... Stronati M.	2010
22	Congenital cytomegalovirus infection. (20840266)	Syggelou A.... Papaevangelou V.	2010
23	Congenital cytomegalovirus infection associated with severe lung involvement in a preterm neonate: a causal relationship? (19224246)	Koklu E.... Sarici S.U.	2009
24	Newborn screening for congenital cytomegalovirus: Options for hospital-based and public health programs. (19783205)	Grosse S.D.... Cannon M.	2009
25	Rehabilitation and outcome of severe profound deafness in a group of 16 infants affected by congenital cytomegalovirus infection. (19283400)	Ciorba A.... Martini A.	2009
26	Microphthalmia and microcornea: in congenital cytomegalovirus. (19574708)	Kava M.P.... Nagarajan L.	2009
27	Retrospective diagnosis of congenital cytomegalovirus infection at a school for the deaf by using preserved dried umbilical cord. (19840618)	Tagawa M.... Moriuchi H.	2009
28	Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. (19317969)	Ludwig A.... Hengel H.	2009
29	A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. (18571542)	Foulon I.... Gordts F.	2008
30	Late onset of ultrasound abnormalities in a case of periconceptional congenital cytomegalovirus infection. (18383478)	Picone O.... Senat M.V.	2008
31	Recent advances in the prevention and treatment of congenital cytomegalovirus infections. (17317422)	Adler S.P.... Pereira L.	2007
32	Nonprimate models of congenital cytomegalovirus (CMV) infection: gaining insight into pathogenesis and prevention of disease in newborns. (16391432)	Schleiss M.R.	2006
33	Screening for congenital cytomegalovirus infection: a tapestry of controversies. (15689898)	Demmler G.J.	2005
34	Congenital cytomegalovirus infection and its prevention. (15034840)	Plotkin S.A.	2004
35	Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection. (15566332)	Burny W.... Marchant A.	2004
36	Birth characteristics and growth pattern in children with congenital cytomegalovirus infection. (14714744)	Ivarsson S.A.... Jonsson B.	2003
37	Congenital Cytomegalovirus Infection. (11931729)	Bale J.F.... Petheram S.J.	2002
38	Congenital cytomegalovirus infection in a northern Italian region. NEOCMV Group. (9928874)	Barbi M.... Clerici D.	1998
39	Congenital cytomegalovirus infection presenting as severe persistent pulmonary hypertension of the newborn. (9659657)	Ng P.C.... Wong W.	1998
40	Schizencephaly and congenital cytomegalovirus infection. (9763793)	Sener R.N.	1998
41	Diagnosis of congenital cytomegalovirus infection by examination of placenta: application of polymerase chain reaction and in situ hybridization. (9086531)	Ozono K.... Nakayama M.	1997
42	Immunization strategy for prevention of congenital cytomegalovirus infection. (8884369)	Pass R.F.	1996
43	Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary CMV infection in the guinea pig model. (7594656)	Harrison C.J.... Tracy S.	1995
44	Congenital cytomegalovirus infection: a case report. (8169681)	Kumar P.... Brans Y.	1994
45	Prenatal diagnosis of 52 pregnancies at risk for congenital cytomegalovirus infection. (8397357)	Donner C.... Rodesch F.	1993
46	Congenital cytomegalovirus infection in Korean population with very high prevalence of maternal immunity. (1329845)	Sohn Y.M.... Lee W.Y.	1992
47	Prenatal diagnosis of congenital cytomegalovirus infection by virus isolation from amniotic fluid. (2171339)	Weiner C.P.... Grose C.	1990
48	Congenital cytomegalovirus infection associated with fetal ascites and intrahepatic calcifications. (2557722)	Yamashita Y.... Hamada T.	1989
49	Cyclopia and congenital cytomegalovirus infection. (2823607)	Byrne P.J.... Tanswell A.K.	1987
50	Congenital cytomegalovirus infection and maternal systemic lupus erythematosus: a case report. (3022760)	Jones M.M.... Williamson W.D.	1986

Genes related to Congenital Cytomegalovirus

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Congenital Cytomegalovirus:

- Elite gene

id	Symbol	Description	Score	Implication
1	GJB2	gap junction protein, beta 2, 26kDa	21.42	GeneCards inferred via : Publications, Disorders (show sections)
2	MT-RNR1	mitochondrially encoded 12S RNA	18.50	GeneCards inferred via : Publications (show sections)
3	GJB6	gap junction protein, beta 6, 30kDa	15.64	GeneCards inferred via : Publications (show sections)
4	RNASET2	ribonuclease T2	12.78	GeneCards inferred via : Publications (show sections)
5	CD40LG	CD40 ligand	9.92	GeneCards inferred via : Publications (show sections)
6	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	7.06	GeneCards inferred via : Publications (show sections)
7	RNR1	RNA, ribosomal cluster 1	4.21	GeneCards inferred via : Publications (show sections)

Products for genes related to Congenital Cytomegalovirus disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	5	5
2	Novus Biologicals	5	5	5	-

Variations for Congenital Cytomegalovirus

Expression for genes affiliated with Congenital Cytomegalovirus

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for genes affiliated with Congenital Cytomegalovirus

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ⁵²QIAGEN, ³⁰KEGG, ⁵⁹Thomson Reuters, ³⁷NCBI BioSystems Database
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Pathways related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Gap junction trafficking⁵⁴ Show member pathways Gap junction trafficking and regulation⁵⁴ Formation of annular gap junctions⁵⁴ Gap junction degradation⁵⁴ Gap junction assembly⁵⁴ Entry of Influenza Virion into Host Cell via Endocytosis⁵⁴	9.6	GJB2, GJB6
2	Signaling in Gap Junctions⁵² Show member pathways Gap junction³⁰	9.6	GJB2, GJB6
3	CFTR translational fidelity class I mutations ⁵⁹ Show member pathways Cytoplasmic Ribosomal Proteins³⁷ Ribosome³⁰	9.5	MT-RNR1, RNR1

Compounds for genes affiliated with Congenital Cytomegalovirus

Sources:
⁶⁰Tocris Bioscience, ²⁹IUPHAR, ²⁵HMDB, ⁴⁴Novoseek, ¹²DrugBank, ³BitterDB, ⁵⁰PharmGKB
See all sources

Compounds related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	10panx⁶⁰	10.0	GJB2, GJB6
2	gap 27⁶⁰	10.0	GJB6, GJB2
3	carbenoxolone disodium⁶⁰	10.0	GJB6, GJB2
4	scrambled 10panx⁶⁰	10.0	GJB6, GJB2
5	octanol²⁹ ²⁵	11.0	GJB2, GJB6
6	carbenoxolone⁴⁴ ²⁹ ¹²	12.0	GJB6, GJB2
7	ca²⁺²⁹	10.0	GJB2, GJB6
8	flufenamic acid²⁹ ⁴⁴ ³ ¹²	12.9	GJB2, GJB6
9	asparagine⁴⁴	9.3	GJB2, GPT
10	ursodeoxycholic acid⁴⁴ ²⁵ ¹²	11.3	GPT, CD40LG
11	valproate⁴⁴	9.3	CD40LG, GPT
12	mycophenolate mofetil⁴⁴ ⁵⁰ ¹²	11.3	CD40LG, GPT
13	fenofibrate⁴⁴ ⁵⁰ ¹²	11.3	GPT, CD40LG
14	ivig⁴⁴	9.3	CD40LG, GPT
15	ribavirin⁴⁴ ⁵⁰ ¹²	11.3	CD40LG, GPT
16	vitamin b12⁴⁴	9.2	CD40LG, GPT
17	neopterin⁴⁴	9.2	CD40LG, GPT
18	pravastatin⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.1	GPT, CD40LG
19	atorvastatin⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.0	CD40LG, GPT
20	hyaluronic acid⁴⁴ ²⁵	10.0	CD40LG, GPT
21	cocaine⁴⁴ ¹²	9.9	GPT, CD40LG
22	aspartate⁴⁴	8.9	GPT, GJB2, CD40LG
23	thyroxine⁴⁴ ²⁵	9.7	CD40LG, GPT

GO Terms for genes affiliated with Congenital Cytomegalovirus

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	connexon complex	GO:005922	9.6	GJB2, GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sensory perception of sound	GO:007605	9.6	GJB2, GJB6

Products for genes affiliated with Congenital Cytomegalovirus

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Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Congenital Cytomegalovirus

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: CNG069 MIFTS: 36	Congenital Cytomegalovirus malady Rare diseases category
7 genes, 12 tissues, 82 related diseases, clinical trials Download this MalaCard Expand all tables

Congenital Cytomegalovirus malady