Congenital Cytomegalovirus disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Congenital Cytomegalovirus

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³²MalaCards
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MalaCards: Congenital Cytomegalovirus is related to sensorineural hearing loss and enlarged vestibular aqueduct. An important gene associated with Congenital Cytomegalovirus is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways is Gap junction trafficking. The compounds 10panx and carbenoxolone disodium have been mentioned in the context of this disorder.

Aliases & Classifications for Congenital Cytomegalovirus

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⁴²NIH Rare Diseases
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Aliases & Descriptions:

congenital cytomegalovirus ⁴²

Related Diseases for Congenital Cytomegalovirus

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 73)

id	Related Disease	Score	Top Affiliating Genes
1	sensorineural hearing loss	30.6	GJB2, GJB6
2	enlarged vestibular aqueduct	29.8	GJB6, GJB2
3	cerebritis	10.2
4	chorioretinitis	10.1
5	retinitis	10.1
6	hydrocephalus	10.0
7	hypertension	10.0
8	labyrinthitis	10.0
9	oligohydramnios	10.0
10	pneumonia	10.0
11	fetal cytomegalovirus syndrome	10.0
12	erythrokeratodermia variabilis	10.0	GJB2
13	cystic fibrosis	10.0	GJB2
14	melanoma	10.0	GJB2
15	palmoplantar keratosis	10.0	GJB6
16	keratoderma	10.0	GJB2
17	usher syndrome	10.0	GJB2
18	cryoglobulinemic vasculitis	10.0	CD40LG
19	cryoglobulinemia	10.0	CD40LG
20	dfnb 1 nonsyndromic hearing loss and deafness	10.0	GJB2, GJB6
21	dfna 3 nonsyndromic hearing loss and deafness	10.0	GJB2, GJB6
22	bart-pumphrey syndrome	10.0	GJB2, GJB6
23	hidrotic ectodermal dysplasia 2	10.0	GJB2, GJB6
24	dfnb1	10.0	GJB6, GJB2
25	clouston syndrome	10.0	GJB2, GJB6
26	colorectal cancer	10.0	RNASET2, GJB2
27	cholecystitis	10.0	GPT
28	rubella	10.0	CD40LG
29	hyperuricemia	10.0	GPT
30	cholelithiasis	10.0	GPT
31	scrub typhus	10.0	CD40LG, GPT
32	autoimmune hepatitis	10.0	GPT, CD40LG
33	hepatitis e	10.0	GPT, CD40LG
34	primary biliary cirrhosis	10.0	GPT, CD40LG
35	periventricular leukomalacia	9.9
36	leukemoid reaction	9.9
37	twin-to-twin transfusion syndrome	9.9
38	autistic disorder	9.9
39	wiskott-aldrich syndrome	9.9
40	systemic lupus erythematosus	9.9
41	diabetes insipidus	9.9
42	thyroid hormone resistance syndrome	9.9
43	microcephaly	9.9
44	neuronitis	9.9
45	microphthalmia	9.9
46	acquired immunodeficiency syndrome	9.9
47	parotitis	9.9
48	congenital toxoplasmosis	9.9
49	horner's syndrome	9.9
50	hydranencephaly	9.9

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:

Clinical Features for Congenital Cytomegalovirus

Drugs & Therapeutics for Congenital Cytomegalovirus

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Cytomegalovirus

Drug clinical trials:

Search ClinicalTrials for Congenital Cytomegalovirus

Search NIH Clinical Center for Congenital Cytomegalovirus

Search CenterWatch for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

Animal Models for Congenital Cytomegalovirus or affiliated genes

Publications for Congenital Cytomegalovirus

Genes related to Congenital Cytomegalovirus

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Congenital Cytomegalovirus:

id	Symbol	Description	Score	Implication
1	GJB2	gap junction protein, beta 2, 26kDa	21.42	GeneCards inferred : Publications, Disorders (show sections)
2	MT-RNR1	mitochondrially encoded 12S RNA	18.49	GeneCards inferred : Publications, Disorders (show sections)
3	GJB6	gap junction protein, beta 6, 30kDa	15.63	GeneCards inferred : Publications, Disorders (show sections)
4	RNASET2	ribonuclease T2	12.77	GeneCards inferred : Publications, Disorders (show sections)
5	CD40LG	CD40 ligand	9.92	GeneCards inferred : Publications, Disorders (show sections)
6	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	7.06	GeneCards inferred : Publications, Disorders (show sections)
7	RNR1	RNA, ribosomal cluster 1	2.99	GeneCards inferred : Publications (show sections)

Products for genes related to Congenital Cytomegalovirus disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	5	5	5
2	LSBio	-	-	7

Genetic Variations for Congenital Cytomegalovirus

Expression for genes affiliated with Congenital Cytomegalovirus

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for genes affiliated with Congenital Cytomegalovirus

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⁵³Reactome
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Pathways related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Gap junction trafficking⁵³ Hide members Gap junction trafficking and regulation⁵³ Gap junction assembly⁵³	9.6	GJB2, GJB6

Compounds for genes affiliated with Congenital Cytomegalovirus

Sources:
⁵⁹Tocris Bioscience, ²⁸IUPHAR, ²⁴HMDB, ⁴⁴Novoseek, ¹¹DrugBank, ²BitterDB, ⁴⁹PharmGKB
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Compounds related to Congenital Cytomegalovirus according to GeneCards/GeneDecks:

(show all 18)

id	Compound	Score	Top Affiliating Genes
1	10panx⁵⁹	10.0	GJB2, GJB6
2	carbenoxolone disodium⁵⁹	10.0	GJB6, GJB2
3	gap 27⁵⁹	9.9	GJB2, GJB6
4	scrambled 10panx⁵⁹	9.9	GJB6, GJB2
5	octanol²⁸ ²⁴	10.9	GJB2, GJB6
6	carbenoxolone²⁸ ⁴⁴ ¹¹	11.9	GJB2, GJB6
7	ca²⁺²⁸	9.9	GJB6, GJB2
8	flufenamic acid⁴⁴ ²⁸ ² ¹¹	12.9	GJB6, GJB2
9	ursodeoxycholic acid⁴⁴ ¹¹ ²⁴	11.3	CD40LG, GPT
10	mycophenolate mofetil⁴⁴ ⁴⁹ ¹¹	11.2	GPT, CD40LG
11	valproate⁴⁴	9.2	GPT, CD40LG
12	fenofibrate⁴⁴ ⁴⁹ ¹¹	11.2	GPT, CD40LG
13	ribavirin⁴⁴ ⁴⁹ ¹¹	11.1	CD40LG, GPT
14	ivig⁴⁴	9.1	GPT, CD40LG
15	vitamin b12⁴⁴	9.0	CD40LG, GPT
16	pravastatin⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	13.0	GPT, CD40LG
17	neopterin⁴⁴	8.9	CD40LG, GPT
18	aspartate⁴⁴	8.4	CD40LG, GJB2, GPT