MCID: CNG069
MIFTS: 36

Congenital Cytomegalovirus malady

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Congenital Cytomegalovirus

Aliases & Descriptions for Congenital Cytomegalovirus:

Name: Congenital Cytomegalovirus 50
Congenital Cytomegalovirus Infection 69

Classifications:



External Ids:

ICD10 33 P35.1

Summaries for Congenital Cytomegalovirus

NIH Rare Diseases : 50 congenital cytomegalovirus (congenital cmv) is a group of symptoms that may occur when an infant is infected with the cytomegalovirus before birth. most infants who are infected with the virus never develop symptoms of the condition. however, approximately 10% of babies will experience health problems and/or disabilities such as problems with the lungs, liver and/or spleen at birth; hearing loss; vision loss; intellectual disability; seizures; small head size; and/or lack of coordination. some babies with the condition may have evidence of infection at birth, while others may not develop symptoms for two or more years. congenital cmv occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta. treatment is based on the signs and symptoms present in each person. last updated: 11/4/2015

MalaCards based summary : Congenital Cytomegalovirus, also known as congenital cytomegalovirus infection, is related to cytomegalovirus infection and dnase1-related susceptibility to systemic lupus erythematosus. An important gene associated with Congenital Cytomegalovirus is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways is Malaria. The drugs Anti-Infective Agents and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and placenta.

Related Diseases for Congenital Cytomegalovirus

Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 cytomegalovirus infection 10.8
2 dnase1-related susceptibility to systemic lupus erythematosus 10.2 GJB2 GJB6
3 down syndrome-related congenital heart disease 10.2 GJB2 GJB6
4 spastic ataxia, charlevoix-saguenay type 10.2 GJB2 GJB6
5 pik3ca-related segmental overgrowth 10.2 GJB2 GJB6
6 bietti crystalline corneoretinal dystrophy 10.2 GJB2 GJB6
7 pink1 type of young-onset parkinson disease 10.2 GJB2 GJB6
8 keratoderma, palmoplantar, with deafness 10.2 GJB2 GJB6
9 klumpke paralysis 10.2 GJB2 GJB6
10 pseudomyotonia 10.2 GJB2 GJB6
11 ectodermal dysplasia 2, clouston type 10.2 GJB2 GJB6
12 troyer syndrome 10.1 GJB2 GJB6
13 die smulders droog van dijk syndrome 10.1 GJB2 GJB6
14 bartter syndrome, type 1 10.1 GJB2 GJB6
15 cataract 26, multiple types 10.1 GJB2 MT-RNR1
16 sturge-weber syndrome, somatic, mosaic 10.1 GJB2 MT-RNR1
17 deafness, autosomal dominant 2a 10.1 GJB2 GJB6
18 efemp2-related cutis laxa 10.1 GJB2 MT-RNR1
19 erythrokeratodermia variabilis et progressiva 10.1 GJB2 GJB6
20 sensorineural hearing loss 10.1
21 omenn syndrome 10.1 GJB2 MT-RNR1
22 congenital myopathy, paradas type 10.1 MT-RNR1 RNR1
23 dementia, familial british 10.0 GJB2 GJB6
24 plp1-related disorders 10.0 MT-RNR1 RNR1
25 erythrocytosis due to bisphosphoglycerate mutase deficiency 10.0 GJB2 GJB6
26 molluscum contagiosum 10.0 GJB2 GJB6 MT-RNR1
27 autoimmune gastrointestinal dysmotility 10.0 GJB2 GJB6 MT-RNR1
28 cerebritis 10.0
29 cockayne syndrome 9.9 GJB2 GJB6 MT-RNR1
30 narcissistic personality disorder 9.9 GJB2 GJB6 MT-RNR1
31 venous insufficiency 9.9 GJB2 GJB6
32 optic nerve hypoplasia 9.9 GJB2 TLR2
33 x-linked nonsyndromic deafness 9.9 GJB2 GJB6 MT-RNR1
34 fetal cytomegalovirus syndrome 9.9
35 cerebral palsy 9.8
36 chorioretinitis 9.8
37 retinitis 9.8
38 hepatitis 9.8
39 obesity susceptibility, adrb3-related 9.8 GJB2 GJB6 MT-RNR1 RNR1
40 cytomegalovirus retinitis 9.7
41 neonatal herpes 9.6
42 oligohydramnios 9.6
43 labyrinthitis 9.6
44 cardiomyopathy 9.6
45 pulmonary hypertension 9.6
46 twin-to-twin transfusion syndrome 9.6
47 pneumonia 9.6
48 hydrocephalus 9.6
49 leukemia 9.5
50 pericardial effusion 9.5

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to Congenital Cytomegalovirus

Symptoms & Phenotypes for Congenital Cytomegalovirus

Drugs & Therapeutics for Congenital Cytomegalovirus

Drugs for Congenital Cytomegalovirus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
2 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Acyclovir Phase 4,Phase 2,Phase 3
4 valacyclovir Phase 4,Phase 2,Phase 3
5
Ganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 82410-32-0 3454
6
Valganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 175865-60-8 64147
7
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
8 Ganciclovir triphosphate Phase 3,Phase 2,Phase 1
9 Pharmaceutical Solutions Phase 3,Phase 2
10 Antibodies Phase 2, Phase 3, Phase 1
11 gamma-Globulins Phase 2, Phase 3
12 Immunoglobulins Phase 2, Phase 3, Phase 1
13 Immunoglobulins, Intravenous Phase 2, Phase 3
14 Rho(D) Immune Globulin Phase 2, Phase 3
15 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
16
Sodium Benzoate Phase 3
17 Immunoglobulin G Phase 3
18 Povidone Phase 3
19
alemtuzumab Approved, Investigational Phase 2 216503-57-0
20
Busulfan Approved, Investigational Phase 2 55-98-1 2478
21
Cyclosporine Approved, Investigational, Vet_approved Phase 2 79217-60-0, 59865-13-3 5284373 6435893
22
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
23
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
24
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
25
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
26
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
27
Vidarabine Approved Phase 2 24356-66-9 32326 21704
28
Melphalan Approved Phase 2 148-82-3 4053 460612
29
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
30
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
32
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
33 Antibodies, Monoclonal Phase 1, Phase 2
34 MF59 oil emulsion Phase 2
35 Vaccines Phase 2,Phase 1
36 Alkylating Agents Phase 2
37 Antiemetics Phase 2
38 Antifungal Agents Phase 2
39 Anti-Inflammatory Agents Phase 2
40 Antimetabolites Phase 2
41 Antimetabolites, Antineoplastic Phase 2
42 Antineoplastic Agents, Alkylating Phase 2
43 Antineoplastic Agents, Hormonal Phase 2
44 Antirheumatic Agents Phase 2
45 Autonomic Agents Phase 2
46 Calcineurin Inhibitors Phase 2
47 Dermatologic Agents Phase 2
48 Folic Acid Antagonists Phase 2
49 Gastrointestinal Agents Phase 2
50 glucocorticoids Phase 2

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 In Utero Treatment of Cytomegalovirus congénitale Infection With Valacyclovir Completed NCT01651585 Phase 4
2 In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir Terminated NCT01037712 Phase 4
3 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment Unknown status NCT02005822 Phase 3
4 A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections. Completed NCT00001100 Phase 3
5 Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection Completed NCT00004278 Phase 3
6 Short-Term vs. Long-Term Valganciclovir Therapy for Symptomatic Congenital CMV Infections Completed NCT00466817 Phase 3
7 Efficacy Study of Human Cytomegalovirus (HCMV) Hyperimmune Globulin to Prevent Congenital HCMV Infection Completed NCT00881517 Phase 2, Phase 3
8 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3
9 Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Recruiting NCT02351102 Phase 2, Phase 3
10 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Not yet recruiting NCT02606266 Phase 2, Phase 3
11 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
12 Randomized Controlled Trial of Valganciclovir for Asymptomatic Cytomegalovirus Infected Hearing Impaired Infants Not yet recruiting NCT03107871 Phase 3
13 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3
14 Valganciclovir in Congenital CMV Infants Completed NCT00031434 Phase 1, Phase 2
15 Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease Completed NCT00004642 Phase 1, Phase 2
16 Recombinant CMV gB Vaccine in Postpartum Women Completed NCT00125502 Phase 2
17 Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders Completed NCT00301834 Phase 2
18 Congenital CMV and Hearing Loss in Children up to 4 Years of Age: Treating With Valganciclovir Therapy Recruiting NCT01649869 Phase 2
19 Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601) Active, not recruiting NCT00745420 Phase 2
20 Safety, Tolerability, and Immunogenicity of a Cytomegalovirus DNA Vaccine Withdrawn NCT02594566 Phase 1
21 Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women With Primary Cytomegalovirus Infection Unknown status NCT01659684
22 Genotyping of Cytomegalovirus From Patients in Israel Unknown status NCT00228202
23 The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment Completed NCT01162330
24 Clinical Trial of Behavioral Modification to Prevent Congenital Cytomegalovirus Completed NCT01819519
25 Neonatal CMV-Ganciclovir Follow-up Study Completed NCT00031421
26 Study of the Transmission of Cytomegalovirus (CMV) Infection From Mother to Foetus Completed NCT01251744
27 Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection? Completed NCT00872703
28 Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital CMV Recruiting NCT02782988
29 Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening Recruiting NCT02139423
30 A Cross-sectional Study of Congenital Cytomegalovirus Infection in Newborns in China Recruiting NCT02710864
31 A Cohort Study of Cytomegalovirus(CMV) Infection Among Pregnant Women and Their Newborns in China Recruiting NCT02645396
32 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Recruiting NCT02680743
33 Prognostic Value of Neonatal Markers (Clinical, Imaging and Biological) for the Development of Neurosensorial Sequelae in Children Infected by Cytomegalovirus (CMV) in Utero Recruiting NCT01923636
34 Biomarkers of Cytomegalovirus Fetal Infection and Disease Recruiting NCT03090841
35 Immunological Characteristics of Maternal-fetal Transmission of Cytomegalovirus in Pregnancy Recruiting NCT02129465
36 Diaplacental Transfer of Anti-HCMV- and Anti-VZV-immunoglobulin G (IgG) -Antibodies at Premature and Mature Newborns Recruiting NCT02689700
37 Biochip for HCMV Detection in Breast Milk Recruiting NCT02840825
38 Evaluation of the PK and PD of Ganciclovir in Premature Infants Receiving Treatment for CMV Infection Recruiting NCT01602614
39 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Recruiting NCT02787486
40 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Recruiting NCT01431326
41 Screening for Congenital Cytomegalovirus Infection in Newborns Enrolling by invitation NCT02683096
42 Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes. Withdrawn NCT01151462

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

MalaCards organs/tissues related to Congenital Cytomegalovirus:

39
Lung, Liver, Placenta, Spleen, Brain, Testes, T Cells

Publications for Congenital Cytomegalovirus

Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 602)
id Title Authors Year
1
T and B Cell Markers in Dried Blood Spots of Neonates with Congenital Cytomegalovirus Infection: B Cell Numbers at Birth Are Associated with Long-Term Outcomes. ( 27903736 )
2017
2
Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study. ( 28056855 )
2017
3
Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women. ( 27986675 )
2017
4
A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening. ( 28049114 )
2017
5
Congenital Cytomegalovirus Infection: Prognostic Value of Maternal DNAemia at Amniocentesis. ( 27986666 )
2017
6
Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss. ( 28501927 )
2017
7
Congenital Cytomegalovirus: a "Now" Problem-No Really, Now. ( 27795304 )
2017
8
Pathogenesis of developmental anomalies of the central nervous system induced by congenital cytomegalovirus infection. ( 28074532 )
2017
9
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
10
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection. ( 27843092 )
2017
11
EP01.11: Congenital cytomegalovirus infection: an interesting case ofA clinical, molecular and pathologic correlations. ( 27646834 )
2016
12
Detection of CMV DNA in the perilymph of a 6-year-old boy with congenital cytomegalovirus infection. ( 27304443 )
2016
13
Clinical Predictors of Sensorineural Hearing Loss and Cognitive Outcome in Infants with Symptomatic Congenital Cytomegalovirus Infection. ( 27195603 )
2016
14
Follow-up of infants with congenital cytomegalovirus and normal fetal imaging. ( 26782597 )
2016
15
Congenital cytomegalovirus-a neglected health problem. ( 27477985 )
2016
16
Longitudinal Kinetics of Cytomegalovirus-Specific T-Cell Immunity and Viral Replication in Infants With Congenital Cytomegalovirus Infection. ( 26908487 )
2016
17
Salivary glands and human congenital cytomegalovirus infection: What happens in early fetal life? ( 27420192 )
2016
18
In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study. ( 27083761 )
2016
19
A Prognostic Neonatal Neuroimaging Scale for Symptomatic Congenital Cytomegalovirus Infection. ( 27344149 )
2016
20
Correlation Between White Matter Lesions and Intelligence Quotient in Patients With Congenital Cytomegalovirus Infection. ( 26778145 )
2016
21
Congenital Cytomegalovirus Infection and Permanent Hearing Loss in Rural North Indian Children. ( 28033238 )
2016
22
An unusual case of congenital cytomegalovirus infection-related retinopathy. ( 27266272 )
2016
23
Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'. ( 26857178 )
2016
24
Intestinal manifestations of postnatal and congenital cytomegalovirus infection in term and preterm infants. ( 27529309 )
2016
25
Congenital Cytomegalovirus. ( 26752783 )
2016
26
Audiovestibular consequences of congenital cytomegalovirus infection. ( 27067701 )
2016
27
Newborn Screening for Congenital Cytomegalovirus Infection in Iran. ( 27518751 )
2016
28
Optimum treatment of congenital cytomegalovirus infection. ( 27043943 )
2016
29
Update on treatment of cytomegalovirus infection in pregnancy and of the newborn with congenital cytomegalovirus. ( 27607910 )
2016
30
Congenital cytomegalovirus related intestinal malrotation: a case report. ( 27923378 )
2016
31
Amniocentesis for Detection of Congenital Cytomegalovirus Infection: What Is the Point? ( 27114377 )
2016
32
Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency. ( 27999698 )
2016
33
Congenital cytomegalovirus infection: contribution and best timing of prenatal MR imaging. ( 26984434 )
2016
34
Neonatal gastrointestinal involvement and congenital cytomegalovirus. ( 28009139 )
2016
35
Asymptomatic congenital cytomegalovirus infection with neurological sequelae: A retrospective study using umbilical cord. ( 27068877 )
2016
36
Diagnosis and antenatal management of congenital cytomegalovirus infection. ( 26902990 )
2016
37
Prevalence, Characteristics, and One-Year Follow-Up of Congenital Cytomegalovirus Infection in Isfahan City, Iran. ( 28070187 )
2016
38
PPARI^ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. ( 27078877 )
2016
39
Failure of Oral Valganciclovir Treatment in Congenital Cytomegalovirus Hepatitis in a Neonate. ( 27099388 )
2016
40
Congenital Cytomegalovirus among Children with Cerebral Palsy. ( 27816221 )
2016
41
Family Teaching Toolbox. A Parent's Guide to Congenital Cytomegalovirus. ( 26808516 )
2016
42
Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection. ( 28034524 )
2016
43
EP01.03: Antenatal ultrasound and MRI findings of congenital cytomegalovirus infection. ( 27645476 )
2016
44
Hearing outcome of infants with congenital cytomegalovirus and hearing impairment. ( 26826174 )
2016
45
Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants. ( 27923951 )
2016
46
Comparison of the Motor Performance and Vestibular Function in Infants with a Congenital Cytomegalovirus Infection or a Connexin 26 Mutation: A Preliminary Study. ( 27505220 )
2016
47
Clinical Implications for Children Born With Congenital Cytomegalovirus Infection Following a Negative Amniocentesis. ( 27114380 )
2016
48
Prospects of a vaccine for the prevention of congenital cytomegalovirus disease. ( 27519596 )
2016
49
Hearing in Children with Congenital Cytomegalovirus Infection: Results of a Longitudinal Study. ( 26858192 )
2016
50
Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection. ( 25657256 )
2015

Variations for Congenital Cytomegalovirus

Expression for Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for Congenital Cytomegalovirus

Pathways related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.31 KLRK1 TLR2

GO Terms for Congenital Cytomegalovirus

Cellular components related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 GJB2 TLR2
2 gap junction GO:0005921 8.96 GJB2 GJB6
3 connexin complex GO:0005922 8.62 GJB2 GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.61 GJB6 PPARG TLR2
2 defense response to Gram-positive bacterium GO:0050830 9.4 KLRK1 TLR2
3 inner ear development GO:0048839 9.37 GJB2 GJB6
4 cell communication GO:0007154 9.32 GJB2 GJB6
5 response to retinoic acid GO:0032526 9.26 GJB2 PPARG
6 response to progesterone GO:0032570 9.16 GJB2 TLR2
7 response to lipopolysaccharide GO:0032496 9.13 GJB2 GJB6 TLR2
8 positive regulation of oligodendrocyte differentiation GO:0048714 8.62 PPARG TLR2

Sources for Congenital Cytomegalovirus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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