MCID: CNG023
MIFTS: 31

Congenital Fibrosarcoma malady

Summaries for Congenital Fibrosarcoma

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32MalaCards
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MalaCards: Congenital Fibrosarcoma, also known as infantile fibrosarcoma, is related to fibrosarcoma and congenital mesoblastic nephroma. An important gene associated with Congenital Fibrosarcoma is EPHA2 (EPH receptor A2), and among its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA. The compounds Adenosine triphosphate and adp have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and tongue.

Aliases & Classifications for Congenital Fibrosarcoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

congenital fibrosarcoma 8 10
infantile fibrosarcoma 8 60


External Ids:

Disease Ontology8 DOID:8418
SNOMED-CT56 52040006, 403996004
NCIt39 C4244

Related Diseases for Congenital Fibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma congenital fibrosarcoma

Diseases related to Congenital Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 25)
idRelated DiseaseScoreTop Affiliating Genes
1fibrosarcoma31.2ETV6, NTRK3
2congenital mesoblastic nephroma30.1ETV6, NTRK3
3leukemia29.9NTRK3, MUSK, ETV6, EPHA2, TEC
4hemangioma10.1
5myofibroma10.0
6fibrosarcoma of bone10.0
7urticaria pigmentosa10.0
8pleomorphic lipoma10.0
9spindle cell lipoma10.0
10fasciitis10.0
11lipoma10.0
12rhabdomyosarcoma10.0
13sarcoma10.0
14urticaria10.0
15heart fibrosarcoma10.0
16choroiditis10.0
17fibrous histiocytoma10.0
18cellular congenital mesoblastic nephroma10.0
19acute leukemia10.0
20chondroma10.0
21histiocytoma10.0
22intestinal obstruction10.0
23pediatric fibrosarcoma10.0
24peritonitis10.0
25myeloproliferative disorder10.0ETV6, NTRK3

Graphical network of the top 20 diseases related to Congenital Fibrosarcoma:



Diseases related to congenital fibrosarcoma

Clinical Features for Congenital Fibrosarcoma

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Drugs & Therapeutics for Congenital Fibrosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Congenital Fibrosarcoma

Search NIH Clinical Center for Congenital Fibrosarcoma

Search CenterWatch for Congenital Fibrosarcoma

Genetic Tests for Congenital Fibrosarcoma

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Anatomical Context for Congenital Fibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Congenital Fibrosarcoma:

32
Colon, Heart, Tongue, Bone

Animal Models for Congenital Fibrosarcoma or affiliated genes

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Publications for Congenital Fibrosarcoma

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50PubMed
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Articles related to Congenital Fibrosarcoma:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
A case of congenital infantile fibrosarcoma of sigmoid colon manifesting as pneumoperitoneum in a newborn. (23341728)
2013
2
Congenital infantile fibrosarcoma: Association with bleeding diathesis. (24265847)
2013
3
Prenatal presentation of fronto-orbital congenital infantile fibrosarcoma: a clinicopathologic report. (23559269)
2013
4
Congenital fibrosarcoma and history of prenatal exposure to petroleum derivatives. (22945410)
2012
5
Congenital infantile fibrosarcoma: a clinical mimicker of hemangioma. (22474726)
2012
6
Congenital osteolytic dural fibrosarcoma presenting as a scalp swelling. (22868023)
2012
7
Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. (21843073)
2011
8
Successful treatment of very large congenital infantile fibrosarcoma. (21955012)
2011
9
Primary congenital infantile fibrosarcoma of the heart: the first confirmed case. (21440163)
2011
10
Congenital fibrosarcoma of the ileum: case report with molecular confirmation and literature review. (21355680)
2011
11
Congenital-infantile fibrosarcoma masquerading as sacrococcygeal teratoma. (22075353)
2011
12
Prenatal management of congenital infantile fibrosarcoma: unexpected outcome. (21618315)
2011
13
A giant congenital fibrosarcoma of the leg. (20442675)
2010
14
Right foot congenital infantile fibrosarcoma treated only with chemotherapy. (20533521)
2010
15
Congenital fibrosarcoma of the chest wall: report of a case. (21430833)
2010
16
Infantile fibrosarcoma of the ileum presenting with congenital bowel obstruction. (20152376)
2010
17
Congenital pulmonary fibrosarcoma in a newborn with hypoglycemia and respiratory distress: case report. (20718195)
2010
18
Congenital fibrosarcoma with a novel complex 3-way translocation t(12;15;19) and unusual histologic features. (18657299)
2008
19
Congenital/infantile fibrosarcoma in a 3-week-old boy. (18478789)
2008
20
Congenital/Infantile fibrosarcoma of the colon: morphologic, immunohistochemical, molecular, and ultrastructural features of a relatively rare tumor in an extraordinary localization. (19011467)
2008
21
Congenital fibrosarcoma with metastasis in a fetus. (15022058)
2004
22
Differential diagnosis of congenital fibrosarcoma. (15262440)
2004
23
Congenital fibrosarcoma of the jejunum in a premature infant with meconium peritonitis. (12776248)
2003
24
Regression of congenital fibrosarcoma to hemangiomatous remnant with histological and genetic findings. (12406191)
2002
25
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)
2001
26
The detection of Tel-TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma. (11169520)
2001
27
Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. (10895816)
2000
28
Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. (10658907)
2000
29
ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma. (10918240)
2000
30
Prenatal sonographic appearance of congenital fibrosarcoma. (9608374)
1998
31
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. (9462753)
1998
32
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. (9823307)
1998
33
Congenital palmar nodule in an infant. Congenital fibrosarcoma. (9192424)
1997
34
Congenital-infantile fibrosarcoma: a clinicopathological study of five patients entered on the Prague children's tumor registry. (8897521)
1996
35
Intrathoracic congenital fibrosarcoma. A case report. (7608883)
1995
36
Congenital fibrosarcoma. Report of three cases. (8772821)
1995
37
Pediatric case of the day. Congenital fibrosarcoma (CFS). (7899610)
1995
38
Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. (8523253)
1995
39
Limb congenital fibrosarcoma: report of two cases and review of the literature. (8292522)
1993
40
Ultrastructural, immunocytochemical, and cytogenetic characterization of a large congenital fibrosarcoma. (1524466)
1992
41
Deletion of part of the short arm of chromosome 17 in a congenital fibrosarcoma. (2204476)
1990
42
Cytogenetic investigation of a case of congenital fibrosarcoma. (2731143)
1989
43
Congenital fibrosarcoma. Preoperative chemotherapy and conservative surgery. (3755646)
1986
44
Congenital fibrosarcoma of the axilla in an infant. (6675544)
1983
45
Congenital fibrosarcoma of the tongue. (7064583)
1982
46
Congenital fibrosarcoma: presence of a histiocytic component. (7388769)
1980
47
Congenital fibrosarcoma metastatic to the choroid. (443333)
1979
48
Pancreaticoduodenectomy in the treatment of congenital fibrosarcoma of the duodenum. (1185470)
1975
49
Congenital fibrosarcoma of the thoracolumbar region. (4607996)
1974
50
Ultrastructure of congenital fibrosarcoma. (5483658)
1970

Genetic Variations for Congenital Fibrosarcoma

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Expression for genes affiliated with Congenital Fibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Fibrosarcoma

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Pathways for genes affiliated with Congenital Fibrosarcoma

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51QIAGEN
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Compounds for genes affiliated with Congenital Fibrosarcoma

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11DrugBank, 24HMDB, 44Novoseek, 28IUPHAR
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Compounds related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Adenosine triphosphate11 249.8TEC, EPHA2, MUSK, NTRK3
2adp44 28 2410.5NTRK3, MUSK, EPHA2, TEC
3tyrosine447.7TPM3, TEC, EPHA2, ETV6, MUSK, NTRK3

GO Terms for genes affiliated with Congenital Fibrosarcoma

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16Gene Ontology
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Biological processes related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6MUSK, NTRK3

Molecular functions related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.0EPHA2, MUSK, NTRK3
2ATP bindingGO:0055248.8TEC, EPHA2, MUSK, NTRK3

Products for genes affiliated with Congenital Fibrosarcoma

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Sources for Congenital Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet