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MCID: CNG023
MIFTS: 30

Congenital Fibrosarcoma malady
8 genes, 4 tissues, 19 related diseases, clinical trials.

Summaries for Congenital Fibrosarcoma

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33MalaCards
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MalaCards: Congenital Fibrosarcoma, also known as infantile fibrosarcoma, is related to mesoblastic nephroma and urticaria pigmentosa. An important gene associated with Congenital Fibrosarcoma is EPHA2 (EPH receptor A2), and among its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA. The compounds Adenosine triphosphate and adp have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and t cells.

Aliases & Classifications for Congenital Fibrosarcoma

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

congenital fibrosarcoma 8 10
infantile fibrosarcoma 8 61


External Ids:

Disease Ontology8 DOID:8418
SNOMED-CT57 52040006, 403996004
NCIt40 C4244

Related Diseases for Congenital Fibrosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the fibrosarcoma family:

adult fibrosarcoma congenital fibrosarcoma

Diseases related to Congenital Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1mesoblastic nephroma10.2
2urticaria pigmentosa10.1
3pleomorphic lipoma10.1
4spindle cell lipoma10.1
5urticaria10.1
6sacrococcygeal teratoma10.1
7teratoma10.1
8heart fibrosarcoma10.0
9myofibroma10.0
10fibrous histiocytoma10.0
11cellular congenital mesoblastic nephroma10.0
12acute leukemia10.0
13enchondroma10.0
14infantile myofibromatosis10.0
15lymphatic malformation10.0
16fibrosarcoma10.0ETV6, NTRK3
17myeloproliferative disorder10.0ETV6, NTRK3
18congenital mesoblastic nephroma10.0ETV6, NTRK3
19leukemia9.9NTRK3, MUSK, ETV6, EPHA2, TEC

Graphical network of diseases related to Congenital Fibrosarcoma:



Diseases related to congenital fibrosarcoma

Clinical Features for Congenital Fibrosarcoma

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Drugs & Therapeutics for Congenital Fibrosarcoma

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Congenital Fibrosarcoma

Search NIH Clinical Center for Congenital Fibrosarcoma

Search CenterWatch for Congenital Fibrosarcoma

Genetic Tests for Congenital Fibrosarcoma

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Anatomical Context for Congenital Fibrosarcoma

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33MalaCards
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MalaCards organs/tissues related to Congenital Fibrosarcoma:

33
Heart, Colon, T cells, Tongue

Animal Models for Congenital Fibrosarcoma or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Congenital Fibrosarcoma

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51PubMed
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Articles related to Congenital Fibrosarcoma:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Congenital infantile fibrosarcoma of the lip. (24138391)
2014
2
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
3
Emergency surgical treatment of an ulcerative and hemorrhagic congenital/infantile fibrosarcoma of the lower leg: case report and literature review. (22568962)
2013
4
Primary giant congenital infantile fibrosarcoma of the left forearm. (23886865)
2013
5
Prenatal presentation of fronto-orbital congenital infantile fibrosarcoma: a clinicopathologic report. (23559269)
2013
6
Unusual case of congenital/infantile fibrosarcoma in a new born. (23860074)
2013
7
Infantile fibrosarcoma - an important differential diagnosis of congenital vascular tumors. (22812410)
2012
8
Congenital infantile fibrosarcoma in a very low-birth-weight infant. (22498408)
2012
9
Recurrent congenital fibrosarcoma with heart metastases. (22217490)
2012
10
Congenital infantile fibrosarcoma of the forearm. (21411358)
2011
11
Right foot congenital infantile fibrosarcoma treated only with chemotherapy. (20533521)
2010
12
Congenital fibrosarcoma of the chest wall: report of a case. (21430833)
2010
13
Infantile fibrosarcoma of the ileum presenting with congenital bowel obstruction. (20152376)
2010
14
Congenital fibrosarcoma with a novel complex 3-way translocation t(12;15;19) and unusual histologic features. (18657299)
2008
15
Unilateral mosaic cutaneous vascular lesions, enchondroma, multiple soft tissue chondromas and congenital fibrosarcoma--a variant of Maffucci syndrome? (18429781)
2008
16
Congenital fibrosarcoma as cause for fetal anemia: prenatal diagnosis and in utero treatment. (19018145)
2008
17
Congenital fibrosarcoma simulating congenital hemangioma. (18304187)
2008
18
Primary colonic congenital infantile fibrosarcoma presenting as meconium peritonitis. (18247031)
2008
19
Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)
2006
20
Congenital fibrosarcoma of the upper extremity--a case report and review of literature. (16366098)
2005
21
Combined prenatal ultrasound and magnetic resonance imaging in an extensive congenital fibrosarcoma: a case report and review of the literature. (15980638)
2005
22
Congenital fibrosarcoma with metastasis in a fetus. (15022058)
2004
23
Management of extensive congenital fibrosarcoma with preoperative chemotherapy. (15456453)
2004
24
Chemotherapy alone for the treatment of congenital fibrosarcoma: is surgery always needed? (12555264)
2003
25
Cellular mesoblastic nephroma: morphologic, cytogenetic and molecular links with congenital fibrosarcoma. (12650516)
2003
26
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephroma. (11801301)
2002
27
Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. (10775267)
2000
28
ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma. (10918240)
2000
29
Congenital fibrosarcoma of the upper extremity. (9734437)
1998
30
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. (9823307)
1998
31
Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. (7722837)
1995
32
Are infantile myofibromatosis, congenital fibrosarcoma and congenital haemangiopericytoma histogenetically related? (7713484)
1995
33
Pediatric case of the day. Congenital fibrosarcoma (CFS). (7899610)
1995
34
Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma. (7987812)
1994
35
Limb congenital fibrosarcoma: report of two cases and review of the literature. (8292522)
1993
36
Consistent numerical chromosome aberrations in congenital fibrosarcoma. (8453601)
1993
37
Ultrastructural, immunocytochemical, and cytogenetic characterization of a large congenital fibrosarcoma. (1524466)
1992
38
Cytogenetic analysis of a congenital fibrosarcoma. (2009510)
1991
39
Congenital fibrosarcoma. (3612464)
1987
40
Congenital fibrosarcoma of the forearm. A case report. (3957990)
1986
41
Congenital fibrosarcoma: a congenital fibrous histiocytoma. (3035524)
1986
42
Complete response of congenital fibrosarcoma to chemotherapy. (2878294)
1986
43
Congenital fibrosarcoma of the tongue. A case report. (6674897)
1983
44
Case report 149. Infantile congenital fibrosarcoma of humerus. (7268465)
1981
45
Congenital fibrosarcoma in the oral cavity. First reported case. (7401835)
1980
46
Congenital fibrosarcoma metastatic to the choroid. (443333)
1979
47
Ultrastructure of congenital fibrosarcoma. (5483658)
1970
48
Congenital fibrosarcoma. (6058170)
1967
49
Congenital fibrosarcoma. (13095275)
1953
50
Congenital fibrosarcoma; report of a case in a newborn infant. (14818531)
1951

Genetic Variations for Congenital Fibrosarcoma

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Expression for genes affiliated with Congenital Fibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Fibrosarcoma

Search GEO for disease gene expression data for Congenital Fibrosarcoma.

Pathways for genes affiliated with Congenital Fibrosarcoma

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52QIAGEN
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Pathways related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Guidance Cues and Growth Cone Motility52
9.7EPHA2, NTRK3
2
Activation of cAMP-Dependent PKA52
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9.3EPHA2, MUSK, NTRK3
3
TGF-Beta Pathway52
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9.3EPHA2, MUSK, NTRK3
4
CREB Pathway52
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9.3NTRK3, MUSK, EPHA2
5
Actin Nucleation by ARP-WASP Complex52
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9.3NTRK3, MUSK, EPHA2
6
Nanog in Mammalian ESC Pluripotency52
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9.3EPHA2, MUSK, NTRK3
7
Akt Signaling52
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8.8TEC, EPHA2, MUSK, NTRK3

Compounds for genes affiliated with Congenital Fibrosarcoma

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11DrugBank, 24HMDB, 45Novoseek, 29IUPHAR
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Compounds related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Adenosine triphosphate11 249.8TEC, EPHA2, MUSK, NTRK3
2adp45 29 2410.5TEC, NTRK3, MUSK, EPHA2
3tyrosine457.7ETV6, NTRK3, MUSK, TPM3, TEC, EPHA2

GO Terms for genes affiliated with Congenital Fibrosarcoma

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16Gene Ontology
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Biological processes related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6MUSK, NTRK3

Molecular functions related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.0EPHA2, MUSK, NTRK3
2ATP bindingGO:0055248.8TEC, EPHA2, MUSK, NTRK3

Products for genes affiliated with Congenital Fibrosarcoma

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Sources for Congenital Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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