Congenital Fibrosarcoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Congenital Fibrosarcoma

Sources:
³²MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard

MalaCards: Congenital Fibrosarcoma, also known as infantile fibrosarcoma, is related to fibrosarcoma and congenital mesoblastic nephroma. An important gene associated with Congenital Fibrosarcoma is EPHA2 (EPH receptor A2), and among its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA. The compounds Adenosine triphosphate and adp have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and tongue.

Aliases & Classifications for Congenital Fibrosarcoma

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁶⁰UMLS, ³⁹NCIt, ⁵⁶SNOMED-CT
See all sources

Aliases & Descriptions:

congenital fibrosarcoma ⁸ ¹⁰

infantile fibrosarcoma ⁸ ⁶⁰

External Ids:

Disease Ontology⁸ DOID:8418

SNOMED-CT⁵⁶ 52040006, 403996004

NCIt³⁹ C4244

UMLS⁶⁰ C0334459

Related Diseases for Congenital Fibrosarcoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma	congenital fibrosarcoma

Diseases related to Congenital Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 25)

id	Related Disease	Score	Top Affiliating Genes
1	fibrosarcoma	31.2	ETV6, NTRK3
2	congenital mesoblastic nephroma	30.1	ETV6, NTRK3
3	leukemia	29.9	NTRK3, MUSK, ETV6, EPHA2, TEC
4	hemangioma	10.1
5	myofibroma	10.0
6	fibrosarcoma of bone	10.0
7	urticaria pigmentosa	10.0
8	pleomorphic lipoma	10.0
9	spindle cell lipoma	10.0
10	fasciitis	10.0
11	lipoma	10.0
12	rhabdomyosarcoma	10.0
13	sarcoma	10.0
14	urticaria	10.0
15	heart fibrosarcoma	10.0
16	choroiditis	10.0
17	fibrous histiocytoma	10.0
18	cellular congenital mesoblastic nephroma	10.0
19	acute leukemia	10.0
20	chondroma	10.0
21	histiocytoma	10.0
22	intestinal obstruction	10.0
23	pediatric fibrosarcoma	10.0
24	peritonitis	10.0
25	myeloproliferative disorder	10.0	ETV6, NTRK3

Graphical network of the top 20 diseases related to Congenital Fibrosarcoma:

Clinical Features for Congenital Fibrosarcoma

Drugs & Therapeutics for Congenital Fibrosarcoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Congenital Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Congenital Fibrosarcoma

Search NIH Clinical Center for Congenital Fibrosarcoma

Search CenterWatch for Congenital Fibrosarcoma

Genetic Tests for Congenital Fibrosarcoma

Anatomical Context for Congenital Fibrosarcoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Congenital Fibrosarcoma:

³²

Colon, Heart, Tongue, Bone

Animal Models for Congenital Fibrosarcoma or affiliated genes

Publications for Congenital Fibrosarcoma

Sources:
⁵⁰PubMed
See all sources

Articles related to Congenital Fibrosarcoma:

(show top 50) (show all 88)

id	Title	Authors	Year
1	Congenital infantile fibrosarcoma of the lip. (24138391)	Bellfield E.J.... Beets-Shay L.	2014
2	Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)	Bruno C.... Pozzi-Mucelli R.	2013
3	A case of congenital infantile fibrosarcoma of sigmoid colon manifesting as pneumoperitoneum in a newborn. (23341728)	Kim H.Y.... Park K.H.	2013
4	Emergency surgical treatment of an ulcerative and hemorrhagic congenital/infantile fibrosarcoma of the lower leg: case report and literature review. (22568962)	Kraneburg U.M.... Khosla R.K.	2013
5	Primary giant congenital infantile fibrosarcoma of the left forearm. (23886865)	Duan S.... Li J.	2013
6	Unusual case of congenital/infantile fibrosarcoma in a new born. (23860074)	Tarik E.... Anouar D.M.	2013
7	Congenital infantile fibrosarcoma in a very low-birth-weight infant. (22498408)	Mukai M.... Chijiiwa K.	2012
8	Recurrent congenital fibrosarcoma with heart metastases. (22217490)	Lohi O.... Arola M.	2012
9	Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. (21843073)	Steelman C.... Shehata B.	2011
10	Successful treatment of very large congenital infantile fibrosarcoma. (21955012)	Hamidah A.... Kanegane H.	2011
11	Congenital-infantile fibrosarcoma masquerading as sacrococcygeal teratoma. (22075353)	Al-Salem A.H.	2011
12	A giant congenital fibrosarcoma of the leg. (20442675)	ErtA1rk C.... OzsaraAs M.C.	2010
13	Right foot congenital infantile fibrosarcoma treated only with chemotherapy. (19998472)	Demir H.A.... BA1yA1kpamukAsu M.	2010
14	Congenital/infantile fibrosarcoma in a 3-week-old boy. (18478789)	Costa D.J.... Brink D.S.	2008
15	Unilateral mosaic cutaneous vascular lesions, enchondroma, multiple soft tissue chondromas and congenital fibrosarcoma--a variant of Maffucci syndrome? (18429781)	Katz P.... Drolet B.	2008
16	Congenital fibrosarcoma as cause for fetal anemia: prenatal diagnosis and in utero treatment. (19018145)	Scheier M.... Marth C.	2008
17	Congenital fibrosarcoma simulating congenital hemangioma. (18304187)	Requena C.... GuillAcn C.	2008
18	Primary colonic congenital infantile fibrosarcoma presenting as meconium peritonitis. (18247031)	Islam S.... Geiger J.D.	2008
19	Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)	Yan A.C.... Honig P.J.	2006
20	Management of extensive congenital fibrosarcoma with preoperative chemotherapy. (15456453)	Grohn M.L.... Suppiah R.	2004
21	Differential diagnosis of congenital fibrosarcoma. (15262440)	Morerio C.... Panarello C.	2004
22	Chemotherapy alone for the treatment of congenital fibrosarcoma: is surgery always needed? (12555264)	Surico G.... Minervini C.	2003
23	Cellular mesoblastic nephroma: morphologic, cytogenetic and molecular links with congenital fibrosarcoma. (12650516)	Henno S.... Dubus P.	2003
24	Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephroma. (11801301)	Sandberg A.A.... Bridge J.A.	2002
25	The detection of Tel-TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma. (11169520)	Dubus P.... Merlio J.P.	2001
26	Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. (10775267)	Liu Q.... Gilliland D.G.	2000
27	Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. (10895816)	Bourgeois J.M.... Sorensen P.H.	2000
28	Prenatal sonographic appearance of congenital fibrosarcoma. (9608374)	Tadmor O.P.... Diamant Y.Z.	1998
29	Congenital fibrosarcoma of the upper extremity. (9734437)	Pousti T.J.... Grier H.	1998
30	Congenital-infantile fibrosarcoma: a clinicopathological study of five patients entered on the Prague children's tumor registry. (8897521)	Kodet R.... Eckschlager T.	1996
31	Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. (7722837)	Hayward P.G.... Perez-Atayde A.R.	1995
32	Are infantile myofibromatosis, congenital fibrosarcoma and congenital haemangiopericytoma histogenetically related? (7713484)	Variend S.... van Gorp J.	1995
33	Congenital fibrosarcoma. Report of three cases. (8772821)	Singh V.P.... Lakhtakia R.	1995
34	Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. (8523253)	Boon L.M.... Mulliken J.B.	1995
35	Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma. (7987812)	Bernstein R.... Carpenter P.M.	1994
36	Consistent numerical chromosome aberrations in congenital fibrosarcoma. (8453601)	Sankary S.... Gollin S.M.	1993
37	Cytogenetic investigation of a case of congenital fibrosarcoma. (2731143)	Speleman F.... van den Berghe H.	1989
38	Congenital fibrosarcoma. (3612464)	Blocker S.... Ternberg J.	1987
39	Congenital fibrosarcoma of the forearm. A case report. (3957990)	Martell J.R.... Barja R.H.	1986
40	Congenital fibrosarcoma: a congenital fibrous histiocytoma. (3035524)	Drut R.	1986
41	Complete response of congenital fibrosarcoma to chemotherapy. (2878294)	Delepine N.... Voisin M.C.	1986
42	Congenital fibrosarcoma of the tongue. A case report. (6674897)	Iannucci A.M.... Menestrina F.	1983
43	Congenital fibrosarcoma of the axilla in an infant. (6675544)	Chiba T.	1983
44	Congenital fibrosarcoma of the tongue. (7064583)	Zanetti B.... Ottolenghi A.	1982
45	Case report 149. Infantile congenital fibrosarcoma of humerus. (7268465)	FaurAc C.... Boccon-Gibod L.	1981
46	Congenital fibrosarcoma in the oral cavity. First reported case. (7401835)	Beeson W.H.... LINGEMAN R.E.	1980
47	Congenital fibrosarcoma of the thoracolumbar region. (4607996)	Grubb R.L.... Dehner L.P.	1974
48	Congenital fibrosarcoma. (6058170)	Balsaver A.M.... Martin R.G.	1967
49	Congenital fibrosarcoma. (13095275)	HARTZ P.H.... GUERRERO TABLANTE T.	1953
50	Congenital fibrosarcoma; report of a case in a newborn infant. (14818531)	WILLIAMS J.O.... SCHRUM D.	1951

Genes related to Congenital Fibrosarcoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Congenital Fibrosarcoma:

id	Symbol	Description	Score	Implication
1	EPHA2	EPH receptor A2	21.17	GeneCards inferred : Disorders (show sections)
2	MUSK	muscle, skeletal, receptor tyrosine kinase	18.67	GeneCards inferred : Disorders (show sections)
3	TPM3	tropomyosin 3	16.17	GeneCards inferred : Disorders (show sections)
4	NTRK3	neurotrophic tyrosine kinase, receptor, type 3	13.67	GeneCards inferred : Publications, Disorders, Functions (show sections)
5	ETV6	ets variant 6	11.45	GeneCards inferred : Publications, Disorders, Functions, Summaries (show sections)
6	GOLGA6A	golgin A6 family, member A	8.67	GeneCards inferred : Disorders (show sections)
7	GOLGA6B	golgin A6 family, member B	6.17	GeneCards inferred : Disorders (show sections)
8	TEC	tec protein tyrosine kinase	3.67	GeneCards inferred : Disorders (show sections)

Products for genes related to Congenital Fibrosarcoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	7	7	7
2	LSBio	-	-	8

Genetic Variations for Congenital Fibrosarcoma

Expression for genes affiliated with Congenital Fibrosarcoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Congenital Fibrosarcoma

Search GEO for disease gene expression data for Congenital Fibrosarcoma.

Pathways for genes affiliated with Congenital Fibrosarcoma

Sources:
⁵¹QIAGEN
See all sources

Pathways related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Guidance Cues and Growth Cone Motility⁵¹	9.7	NTRK3, EPHA2
2	Activation of cAMP-Dependent PKA⁵¹ Hide members Activation of PKA through GPCR⁵¹ cAMP Pathway⁵¹	9.3	EPHA2, MUSK, NTRK3
3	TGF-Beta Pathway⁵¹ Hide members JAK-STAT Pathway⁵¹ JNK Pathway⁵¹	9.3	NTRK3, MUSK, EPHA2
4	CREB Pathway⁵¹ Hide members Intracellular Calcium Signaling⁵¹ Activation of PKC through GPCR⁵¹	9.3	NTRK3, MUSK, EPHA2
5	Actin Nucleation by ARP-WASP Complex⁵¹ Hide members CDC42 Pathway⁵¹ Actin Nucleation and Branching⁵¹	9.3	NTRK3, MUSK, EPHA2
6	Nanog in Mammalian ESC Pluripotency⁵¹ Hide members GSK3 Signaling⁵¹ eNOS Signaling⁵¹ 14-3-3 Induced Intracellular Signaling⁵¹	9.3	NTRK3, MUSK, EPHA2
7	Akt Signaling⁵¹ Hide members Tec Kinases Signaling⁵¹ p38 Signaling⁵¹	8.8	NTRK3, MUSK, EPHA2, TEC

Compounds for genes affiliated with Congenital Fibrosarcoma

Sources:
¹¹DrugBank, ²⁴HMDB, ⁴⁴Novoseek, ²⁸IUPHAR
See all sources

Compounds related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	Adenosine triphosphate¹¹ ²⁴	9.8	TEC, EPHA2, MUSK, NTRK3
2	adp⁴⁴ ²⁸ ²⁴	10.5	NTRK3, MUSK, EPHA2, TEC
3	tyrosine⁴⁴	7.7	TPM3, TEC, EPHA2, ETV6, MUSK, NTRK3