MCID: CNG023
MIFTS: 31

Congenital Fibrosarcoma malady

Summaries for Congenital Fibrosarcoma

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32MalaCards
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MalaCards: Congenital Fibrosarcoma, also known as infantile fibrosarcoma, is related to fibrosarcoma and congenital mesoblastic nephroma. An important gene associated with Congenital Fibrosarcoma is EPHA2 (EPH receptor A2), and among its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA. The compounds Adenosine triphosphate and adp have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and tongue.

Aliases & Classifications for Congenital Fibrosarcoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

congenital fibrosarcoma 8 10
infantile fibrosarcoma 8 60


External Ids:

Disease Ontology8 DOID:8418
SNOMED-CT56 52040006, 403996004
NCIt39 C4244

Related Diseases for Congenital Fibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma congenital fibrosarcoma

Diseases related to Congenital Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 25)
idRelated DiseaseScoreTop Affiliating Genes
1fibrosarcoma31.2ETV6, NTRK3
2congenital mesoblastic nephroma30.1ETV6, NTRK3
3leukemia29.9NTRK3, MUSK, ETV6, EPHA2, TEC
4hemangioma10.1
5myofibroma10.0
6fibrosarcoma of bone10.0
7urticaria pigmentosa10.0
8pleomorphic lipoma10.0
9spindle cell lipoma10.0
10fasciitis10.0
11lipoma10.0
12rhabdomyosarcoma10.0
13sarcoma10.0
14urticaria10.0
15heart fibrosarcoma10.0
16choroiditis10.0
17fibrous histiocytoma10.0
18cellular congenital mesoblastic nephroma10.0
19acute leukemia10.0
20chondroma10.0
21histiocytoma10.0
22intestinal obstruction10.0
23pediatric fibrosarcoma10.0
24peritonitis10.0
25myeloproliferative disorder10.0ETV6, NTRK3

Graphical network of the top 20 diseases related to Congenital Fibrosarcoma:



Diseases related to congenital fibrosarcoma

Clinical Features for Congenital Fibrosarcoma

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Drugs & Therapeutics for Congenital Fibrosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Congenital Fibrosarcoma

Search NIH Clinical Center for Congenital Fibrosarcoma

Search CenterWatch for Congenital Fibrosarcoma

Genetic Tests for Congenital Fibrosarcoma

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Anatomical Context for Congenital Fibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Congenital Fibrosarcoma:

32
Colon, Heart, Tongue, Bone

Animal Models for Congenital Fibrosarcoma or affiliated genes

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Publications for Congenital Fibrosarcoma

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50PubMed
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Articles related to Congenital Fibrosarcoma:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Congenital infantile fibrosarcoma of the lip. (24138391)
2014
2
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
3
A case of congenital infantile fibrosarcoma of sigmoid colon manifesting as pneumoperitoneum in a newborn. (23341728)
2013
4
Emergency surgical treatment of an ulcerative and hemorrhagic congenital/infantile fibrosarcoma of the lower leg: case report and literature review. (22568962)
2013
5
Primary giant congenital infantile fibrosarcoma of the left forearm. (23886865)
2013
6
Unusual case of congenital/infantile fibrosarcoma in a new born. (23860074)
2013
7
Congenital infantile fibrosarcoma in a very low-birth-weight infant. (22498408)
2012
8
Recurrent congenital fibrosarcoma with heart metastases. (22217490)
2012
9
Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. (21843073)
2011
10
Successful treatment of very large congenital infantile fibrosarcoma. (21955012)
2011
11
Congenital-infantile fibrosarcoma masquerading as sacrococcygeal teratoma. (22075353)
2011
12
A giant congenital fibrosarcoma of the leg. (20442675)
2010
13
Right foot congenital infantile fibrosarcoma treated only with chemotherapy. (19998472)
2010
14
Congenital/infantile fibrosarcoma in a 3-week-old boy. (18478789)
2008
15
Unilateral mosaic cutaneous vascular lesions, enchondroma, multiple soft tissue chondromas and congenital fibrosarcoma--a variant of Maffucci syndrome? (18429781)
2008
16
Congenital fibrosarcoma as cause for fetal anemia: prenatal diagnosis and in utero treatment. (19018145)
2008
17
Congenital fibrosarcoma simulating congenital hemangioma. (18304187)
2008
18
Primary colonic congenital infantile fibrosarcoma presenting as meconium peritonitis. (18247031)
2008
19
Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)
2006
20
Management of extensive congenital fibrosarcoma with preoperative chemotherapy. (15456453)
2004
21
Differential diagnosis of congenital fibrosarcoma. (15262440)
2004
22
Chemotherapy alone for the treatment of congenital fibrosarcoma: is surgery always needed? (12555264)
2003
23
Cellular mesoblastic nephroma: morphologic, cytogenetic and molecular links with congenital fibrosarcoma. (12650516)
2003
24
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephroma. (11801301)
2002
25
The detection of Tel-TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma. (11169520)
2001
26
Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. (10775267)
2000
27
Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. (10895816)
2000
28
Prenatal sonographic appearance of congenital fibrosarcoma. (9608374)
1998
29
Congenital fibrosarcoma of the upper extremity. (9734437)
1998
30
Congenital-infantile fibrosarcoma: a clinicopathological study of five patients entered on the Prague children's tumor registry. (8897521)
1996
31
Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. (7722837)
1995
32
Are infantile myofibromatosis, congenital fibrosarcoma and congenital haemangiopericytoma histogenetically related? (7713484)
1995
33
Congenital fibrosarcoma. Report of three cases. (8772821)
1995
34
Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. (8523253)
1995
35
Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma. (7987812)
1994
36
Consistent numerical chromosome aberrations in congenital fibrosarcoma. (8453601)
1993
37
Cytogenetic investigation of a case of congenital fibrosarcoma. (2731143)
1989
38
Congenital fibrosarcoma. (3612464)
1987
39
Congenital fibrosarcoma of the forearm. A case report. (3957990)
1986
40
Congenital fibrosarcoma: a congenital fibrous histiocytoma. (3035524)
1986
41
Complete response of congenital fibrosarcoma to chemotherapy. (2878294)
1986
42
Congenital fibrosarcoma of the tongue. A case report. (6674897)
1983
43
Congenital fibrosarcoma of the axilla in an infant. (6675544)
1983
44
Congenital fibrosarcoma of the tongue. (7064583)
1982
45
Case report 149. Infantile congenital fibrosarcoma of humerus. (7268465)
1981
46
Congenital fibrosarcoma in the oral cavity. First reported case. (7401835)
1980
47
Congenital fibrosarcoma of the thoracolumbar region. (4607996)
1974
48
Congenital fibrosarcoma. (6058170)
1967
49
Congenital fibrosarcoma. (13095275)
1953
50
Congenital fibrosarcoma; report of a case in a newborn infant. (14818531)
1951

Genetic Variations for Congenital Fibrosarcoma

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Expression for genes affiliated with Congenital Fibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Fibrosarcoma

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Pathways for genes affiliated with Congenital Fibrosarcoma

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51QIAGEN
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Compounds for genes affiliated with Congenital Fibrosarcoma

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11DrugBank, 24HMDB, 44Novoseek, 28IUPHAR
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Compounds related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Adenosine triphosphate11 249.8TEC, EPHA2, MUSK, NTRK3
2adp44 28 2410.5NTRK3, MUSK, EPHA2, TEC
3tyrosine447.7TPM3, TEC, EPHA2, ETV6, MUSK, NTRK3

GO Terms for genes affiliated with Congenital Fibrosarcoma

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16Gene Ontology
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Biological processes related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6MUSK, NTRK3

Molecular functions related to Congenital Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.0EPHA2, MUSK, NTRK3
2ATP bindingGO:0055248.8TEC, EPHA2, MUSK, NTRK3

Products for genes affiliated with Congenital Fibrosarcoma

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Sources for Congenital Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet