Congenital Generalized Lipodystrophy Type 1 malady

MalaCards: Congenital Generalized Lipodystrophy Type 1, also known as berardinelli-seip congenital lipodystrophy type 1, is related to familial partial lipodystrophy and congenital generalized lipodystrophy type 2. An important gene associated with Congenital Generalized Lipodystrophy Type 1 is AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)).

OMIM: 608594

congenital generalized lipodystrophy type 1 30 16 43 berardinelli-seip congenital lipodystrophy type 1 30 16 bscl1 30 16 berardinelli-seip congenital generalized lipodystrophy type 1 16

lipodystrophy, congenital generalized, type 1 33 agpat2-related brunzell syndrome 16 lipodystrophy 43 bscl type 1 16

Disease types for congenital generalized lipodystrophy family:

congenital generalized lipodystrophy type 1	congenital generalized lipodystrophy type 2
congenital generalized lipodystrophy type 4	lipodystrophy, congenital generalized, type 3

Diseases related to congenital generalized lipodystrophy type 1 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 78)

id	Related Disease	Score	Top Affiliating Genes
1	familial partial lipodystrophy	10.0
2	congenital generalized lipodystrophy type 2	9.3
3	congenital generalized lipodystrophy	8.7
4	congenital generalized lipodystrophy type 4	8.7
5	lipodystrophy, congenital generalized, type 3	8.1
6	lipodystrophy	8.1
7	lipodystrophy, familial partial, type 2	8.0
8	neuropathy	7.9
9	distal hereditary motor neuropathy	7.7
10	familial partial lipodystrophy type 3	7.4
11	muscular dystrophy	7.4
12	motor neuron disease	7.3
13	paraplegia	7.3
14	spastic paraplegia	7.3
15	spastic paraplegia 17	7.3
16	spasticity	7.3
17	barraquer-simons syndrome	7.2
18	distal hereditary motor neuropathy type v	7.0
19	insulin resistance	7.0
20	mandibuloacral dysplasia with type b lipodystrophy	6.9
21	autoinflammation, lipodystrophy, and dermatosis syndrome	6.6
22	atypical lipodystrophy	6.6
23	bscl2-related neurologic disorders/seipinopathy	6.6
24	corpus callosum	6.6
25	hereditary spastic paraplegia	6.6
26	mandibuloacral dysplasia	6.6
27	muscular atrophy	6.6
28	spinal muscular atrophy	6.6
29	atherosclerosis	6.3
30	familial partial lipodystrophy, kobberling type	6.3
31	lipoatrophic diabetes	6.3
32	mandibuloacral dysplasia with type a lipodystrophy	6.3
33	nasu-hakola disease	6.3
34	whipple disease	6.3
35	hypertriglyceridemia	6.1
36	neurodegeneration	6.1
37	silver spastic paraplegia syndrome	6.1
38	acanthosis nigricans	6.1
39	multiple symmetric lipomatosis	5.7
40	nephropathy	5.7
41	panniculitis	5.7
42	short syndrome	5.7
43	type 2 diabetes mellitus	5.7
44	chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature	5.7
45	emery-dreifuss muscular dystrophy	5.7
46	hyperlipidemia	5.7
47	jmp syndrome	5.7
48	charcot-marie-tooth neuropathy	5.2
49	cervicitis	5.2
50	dermatomyositis	4.8

Clinical features from OMIM: 608594

Approved drugs:

Drug clinical trials:

Genetic tests related to congenital generalized lipodystrophy type 1:

id	Genetic test	Affiliating Genes
1	Congenital Generalized Lipodystrophy Type 1 clinical/research	AGPAT2

Genes related to congenital generalized lipodystrophy type 1 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	11.0	Disorders