MCID: CNG022
MIFTS: 24

Congenital Granular Cell Tumor malady

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Congenital Granular Cell Tumor

Aliases & Descriptions for Congenital Granular Cell Tumor:

Name: Congenital Granular Cell Tumor 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:8303

Summaries for Congenital Granular Cell Tumor

MalaCards based summary : Congenital Granular Cell Tumor is related to congenital epulis and granular cell tumor. An important gene associated with Congenital Granular Cell Tumor is ENO2 (Enolase 2). The drugs Fentanyl and pancreatic polypeptide have been mentioned in the context of this disorder. Affiliated tissues include tongue, and related phenotype is Decreased melanin production.

Related Diseases for Congenital Granular Cell Tumor

Graphical network of the top 20 diseases related to Congenital Granular Cell Tumor:



Diseases related to Congenital Granular Cell Tumor

Symptoms & Phenotypes for Congenital Granular Cell Tumor

GenomeRNAi Phenotypes related to Congenital Granular Cell Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased melanin production GR00056-A 8.62 ENO2 LYZ

Drugs & Therapeutics for Congenital Granular Cell Tumor

Drugs for Congenital Granular Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 pancreatic polypeptide Phase 3
3 Analgesics Phase 3
4 Adjuvants, Anesthesia Phase 3
5 Narcotics Phase 3
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Liver Extracts Phase 3
12 Central Nervous System Depressants Phase 3
13 Cola Nutraceutical Phase 3
14
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
15
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
16
Melphalan Approved Phase 2 148-82-3 4053 460612
17
Mycophenolic acid Approved Phase 2 24280-93-1 446541
18
Mycophenolate mofetil Approved, Investigational Phase 2 128794-94-5 5281078
19
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
20
Vidarabine Approved Phase 2 24356-66-9 32326 21704
21
Mechlorethamine Approved Phase 2 51-75-2 4033
22
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
24 Alkylating Agents Phase 2
25 Folic Acid Antagonists Phase 2
26 Nucleic Acid Synthesis Inhibitors Phase 2
27 Dermatologic Agents Phase 2
28 Vidarabine Phosphate Phase 2
29 Vitamin B Complex Phase 2
30 Anti-Bacterial Agents Phase 2
31 Anti-Infective Agents Phase 2
32 Immunosuppressive Agents Phase 2
33 Antimetabolites Phase 2
34 Antibiotics, Antitubercular Phase 2
35 Antimetabolites, Antineoplastic Phase 2
36 Antirheumatic Agents Phase 2
37 Antineoplastic Agents, Alkylating Phase 2
38 Calcineurin Inhibitors Phase 2
39 Antiviral Agents Phase 2
40 Folate Nutraceutical Phase 2
41 phenylalanine Nutraceutical Phase 2
42 Vitamin B9 Nutraceutical Phase 2
43
Cyclosporine Approved, Investigational, Vet_approved 79217-60-0, 59865-13-3 5284373 6435893
44
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
45 Antifungal Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2
3 Oral Magnesium Pidolate, Hemoglobin SC Disease, MG Pidolate Terminated NCT00040456 Phase 2
4 MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Completed NCT01231919 Phase 1
5 Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies Active, not recruiting NCT00014235

Search NIH Clinical Center for Congenital Granular Cell Tumor

Genetic Tests for Congenital Granular Cell Tumor

Anatomical Context for Congenital Granular Cell Tumor

MalaCards organs/tissues related to Congenital Granular Cell Tumor:

39
Tongue

Publications for Congenital Granular Cell Tumor

Articles related to Congenital Granular Cell Tumor:

(show all 18)
id Title Authors Year
1
Congenital granular cell tumor in a child with tetralogy of Fallot. ( 27434473 )
2016
2
Congenital granular cell tumor - a rare entity. ( 26034711 )
2015
3
From newborn to toddler: report of two cases of congenital granular cell tumor. ( 25579012 )
2015
4
Congenital Granular Cell Tumor of the Arm: A Rare Presentation. ( 25321084 )
2014
5
Congenital granular cell tumor with uncommon clinical behavior. ( 23917999 )
2013
6
Congenital granular cell tumor in newborn. ( 24932127 )
2013
7
Solitary S-100-Positive Congenital Granular Cell Tumor of the Tongue: A Case Report and Literature Review. ( 23241807 )
2012
8
Congenital granular cell tumor of the alveolar ridge. ( 20551547 )
2010
9
Congenital granular cell tumor. ( 19461349 )
2009
10
Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest. ( 17909507 )
2007
11
Congenital granular cell tumor (epulis): postnatal imaging appearances. ( 16012311 )
2005
12
Congenital granular cell tumor in the newborn. ( 9627266 )
1998
13
Congenital granular-cell tumor of the gingiva. ( 9799384 )
1998
14
Congenital granular cell tumor (congenital epulis) in the fetus: a case report. ( 9371136 )
1997
15
Immunoreactivity of S100 protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. ( 8878020 )
1996
16
Congenital granular cell tumor with systemic involvement. Immunohistochemical and ultrastructural study. ( 1929790 )
1991
17
Congenital granular cell tumor of the tongue. ( 3667301 )
1987
18
Congenital granular-cell tumor of alveolar ridge and tongue. Report of two cases. ( 168531 )
1975

Variations for Congenital Granular Cell Tumor

Expression for Congenital Granular Cell Tumor

Search GEO for disease gene expression data for Congenital Granular Cell Tumor.

Pathways for Congenital Granular Cell Tumor

GO Terms for Congenital Granular Cell Tumor

Cellular components related to Congenital Granular Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.26 ENO2 LYZ SERPINA1 UBC
2 myelin sheath GO:0043209 9.16 ENO2 UBC
3 extracellular space GO:0005615 8.92 ENO2 LYZ SERPINA1 UBC

Biological processes related to Congenital Granular Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.8 LYZ SERPINA1 UBC

Molecular functions related to Congenital Granular Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 SERPINA1 UBC

Sources for Congenital Granular Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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