MCID: CNG401
MIFTS: 62

Congenital Heart Disease malady

Genetic diseases (common), Cardiovascular diseases categories

Aliases & Classifications for Congenital Heart Disease

About this section

Congenital Heart Disease, Aliases & Descriptions:

Name: Congenital Heart Disease 9 63 43 60
Congenital Heart Defects 9 32 3
Heart Diseases 43 32 60
Heart Failure 43 32 60
Heart Disease 9 11 3
Heart Defects Congenital 43 22
 
Congenital Heart Defect 9 11
Congenital Anomaly of Heart 9
Congestive Heart Failure 60
Heart Malformation 9
Heart Defect 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Cardiovascular diseases


Summaries for Congenital Heart Disease

About this section


MedlinePlus:32 If you're like most people, you think that heart disease is a problem for others. but heart disease is the number one killer in the u.s. it is also a major cause of disability. there are many different forms of heart disease. the most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself. this is called coronary artery disease and happens slowly over time. it's the major reason people have heart attacks. other kinds of heart problems may happen to the valves in the heart, or the heart may not pump well and cause heart failure. some people are born with heart disease. you can help reduce your risk of heart disease by taking steps to control factors that put you at greater risk: control your blood pressure lower your cholesterol don't smoke get enough exercise nih: national heart, lung, and blood institute

MalaCards based summary: Congenital Heart Disease, also known as congenital heart defects, is related to ventricular septal defect and ischemic heart disease, and has symptoms including hypoplastic left heart An important gene associated with Congenital Heart Disease is ZIC3 (Zic family member 3), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and NFAT and Cardiac Hypertrophy. The drugs inamrinone and atenolol have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Disease Ontology:9 A cardiovascular system disease that involves the heart.

CDC:3 In the United States, the most common type of heart disease is coronary artery disease (CAD), which can lead to heart attack. You can greatly reduce your risk for CAD through lifestyle changes and, in some cases, medication. Learn more about heart disease.

Wikipedia:63 Congenital heart defect (CHD) or congenital heart anomaly is a defect in the structure of the heart and... more...

Related Diseases for Congenital Heart Disease

About this section

Diseases in the Congenital Heart Disease family:

Congenital Heart Defects, Multiple Types, 3 Congenital Heart Defects, Multiple Types, 4
Congenital Heart Defects, Nonsyndromic, 2

Diseases related to Congenital Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1055)
idRelated DiseaseScoreTop Affiliating Genes
1ventricular septal defect30.6CFC1
2ischemic heart disease11.2
3hypertensive heart disease11.0
4critical congenital heart disease10.9
5pulmonary hypertension10.6
6myocardial infarction10.6
7beriberi10.5
8chronic pulmonary heart disease10.5
9ischemia10.5
10eisenmenger syndrome10.5
11heterotaxy10.5
12chagas disease10.4
13cardiogenic shock10.4
14pancreatic agenesis and congenital heart defects10.4
15coronary artery disease10.4
16congenital heart defects, multiple types, 310.4
17heterotaxy, visceral, 1, x-linked10.4
18protein-losing enteropathy10.4
19endocarditis10.4
20sleep disorder10.4
21conotruncal heart malformations10.4
22sacral meningocele conotruncal heart defects10.4
23artery disease10.4
24atrial fibrillation10.4
25tetralogy of fallot10.4
26infective endocarditis10.4
27endotheliitis10.4
28hypertension, diastolic10.3
29angina pectoris10.3
30carcinoid syndrome10.3
31multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects10.3
32muscular dystrophy10.3
33giant cell myocarditis10.3
34dilated cardiomyopathy10.3
35cerebrovascular disease10.3
36digeorge syndrome10.3
37polydactyly10.3
38choanal atresia10.3
39tracheal stenosis10.3
40acquired von willebrand syndrome10.3
41cardiocranial syndrome10.3
42cor triatriatum10.3
43shoulder and thorax deformity congenital heart disease10.3
44transposition of the great arteries10.3
45hypoxia10.3
46pulmonary function10.3
47acute myocardial infarction10.3
48arthritis10.3
49kyphoscoliotic heart disease10.3
50neural tube defects10.3

Graphical network of the top 20 diseases related to Congenital Heart Disease:



Diseases related to congenital heart disease

Symptoms for Congenital Heart Disease

About this section

HPO human phenotypes related to Congenital Heart Disease:

id Description Frequency HPO Source Accession
1 hypoplastic left heart HP:0004383

Drugs & Therapeutics for Congenital Heart Disease

About this section

Genetic Tests for Congenital Heart Disease

About this section

Genetic tests related to Congenital Heart Disease:

id Genetic test Affiliating Genes
1 Congenital Heart Disease22

Anatomical Context for Congenital Heart Disease

About this section

MalaCards organs/tissues related to Congenital Heart Disease:

31
Heart, Lung, Brain, Endothelial, Testes, Thyroid, Liver, Pancreas, Skin, Placenta, T cells, Pituitary, Neutrophil

Animal Models for Congenital Heart Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Congenital Heart Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.4GATA4, ZIC3, CFC1, HAND2
2MP:00053709.3HAND2, CFC1, ZIC3, GATA4
3MP:00053809.0GATA4, ZIC3, CFC1, HAND1, HAND2
4MP:00053858.7HAND2, HAND1, CFC1, ZIC3, GATA4

Publications for Congenital Heart Disease

About this section

Articles related to Congenital Heart Disease:

(show top 50)    (show all 635)
idTitleAuthorsYear
1
Impact of Educational Video on Critical Congenital Heart Disease Screening. (24607664)
2014
2
Human Milk and Breastfeeding Outcomes in Infants with Congenital Heart Disease. (25375194)
2014
3
Current era survival of patients with pulmonary arterial hypertension associated with congenital heart disease: a comparison between clinical subgroups. (23455361)
2014
4
Feasibility of critical congenital heart disease newborn screening at moderate altitude. (24567022)
2014
5
Congenital heart disease in monochorionic twins with and without twin-to-twin transfusion syndrome. (24827120)
2014
6
Critical congenital heart disease screening tools may reduce neonatal deaths. (25585444)
2014
7
U.S. international efforts on critical congenital heart disease screening: can we have a uniform recommendation for Europe? (25220118)
2014
8
Cardiology patient page. Screening for critical congenital heart disease in newborns. (25156919)
2014
9
Implementation of critical congenital heart disease screening in Minnesota. (23958775)
2013
10
Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease. (23041100)
2013
11
Hospitalizations, costs, and mortality among infants with critical congenital heart disease: how important is timely detection? (24000201)
2013
12
Body mass index and the development of amiodarone-induced thyrotoxicosis in adults with congenital heart disease--a cohort study. (22386642)
2013
13
Newborn Pulse Oximetry Screening to Detect Critical Congenital Heart Disease. (24315501)
2013
14
No association of functional variant in pri-miR-218 and risk of congenital heart disease in a Chinese population. (23566829)
2013
15
Hospitalizations and mortality in the United States for adults with Down syndrome and congenital heart disease. (23332593)
2013
16
Incidence of patent foramen ovale and migraine headache in adults with congenital heart disease with no known cardiac shunts. (22927216)
2013
17
Prevalence and spectrum of GATA5 mutations associated with congenital heart disease. (23031282)
2013
18
Limitations of Cerebral Oxygenation Monitoring by Near-Infrared Spectroscopy in Children With Cyanotic Congenital Heart Disease and Profound Polycythemia. (23089260)
2012
19
Methylenetetrahydrofolate reductase gene 677CT polymorphism and isolated congenital heart disease in a Mexican population. (22197386)
2012
20
ISL1 common variant rs1017 is not associated with susceptibility to congenital heart disease in a Chinese population. (22480195)
2012
21
Transesophageal echocardiographic appearance and magnetic resonance imaging of a rare congenital heart disease: Gerbode defect. (21282202)
2011
22
Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease. (21858219)
2011
23
Plasma von Willebrand factor as a predictor of survival in pulmonary arterial hypertension associated with congenital heart disease. (22068906)
2011
24
Levels of N-terminal-pro-brain natriuretic peptide in congenital heart disease surgery and its value as a predictive biomarker. (21131684)
2011
25
Endothelin receptor antagonists are an effective long term treatment option in pulmonary arterial hypertension associated with congenital heart disease with or without trisomy 21. (20728407)
2010
26
T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease. (18834961)
2008
27
Mutation analysis of the CHD7 gene in patients with congenital heart disease]. (19065520)
2008
28
Changes of the levels of adrenomedulin, endothelin-1 and nitric oxide in children with pulmonary hypertension secondary to congenital heart disease]. (18211765)
2007
29
Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart disease. (17164490)
2007
30
Management of pulmonary arterial hypertension associated with congenital heart disease. (18333354)
2007
31
Two rare cases of left and right atrial congenital heart disease: cor triatriatum dexter and sinister. (17225917)
2007
32
Heterotaxia, congenital heart disease, and primary ciliary dyskinesia. (17548739)
2007
33
Mutations in the EGF-CFC gene cryptic are an infrequent cause of congenital heart disease. (17072672)
2006
34
Can brain natriuretic peptide levels aid diagnosis in children with congenital heart disease? (16810169)
2006
35
B-type natriuretic peptide in paediatric patients with congenital heart disease. (16467354)
2006
36
Polymorphism of methionine synthase gene in nuclear families of congenital heart disease. (15202865)
2004
37
Surgical management of infants with congenital lobar emphysema and concomitant congenital heart disease. (15769700)
2004
38
Coil embolization of a patent ductus venosus in a 52-day-old girl with congenital heart disease. (12537231)
2003
39
Role of adrenomedullin in congenital heart disease associated with pulmonary hypertension. (14526432)
2003
40
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. (12798584)
2003
41
Plasma nitric oxide products correlate with cardiac index of congenital heart disease. (10865019)
2000
42
Heparin therapy and reversal of protein-losing enteropathy in a case with congenital heart disease. (10818189)
2000
43
Isolated corrected transposition of great arteries and double left anterior descending artery originating from the left and right coronary artery. A rate combination of coronary artery anomaly and congenital heart disease. (8546348)
1996
44
Coexpression of alpha and beta myosin heavy-chain isoforms in atria of neonates and infants with congenital heart disease. (8240229)
1993
45
Inhaled nitric oxide in congenital heart disease. (8425292)
1993
46
Uridine-responsive hypogammaglobulinemia and congenital heart disease in a patient with hereditary orotic aciduria. (3183846)
1988
47
Syndrome of anotia, facial paralysis, and congenital heart disease. (6470867)
1984
48
Congenital hepatic fibrosis with congenital heart disease. A family study with ultrastructural features of the liver. (7429344)
1980
49
Congenital heart disease in congenital hemihypertrophy. (5141736)
1971
50
Congenital heart disease in an adult with the Ellis-van Creveld syndrome. (13994651)
1962

Variations for Congenital Heart Disease

About this section

Expression for genes affiliated with Congenital Heart Disease

About this section
Search GEO for disease gene expression data for Congenital Heart Disease.

Pathways for genes affiliated with Congenital Heart Disease

About this section

Pathways related to Congenital Heart Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GATA4, ZIC3, HAND1
2
Show member pathways
9.5GATA4, HAND1, HAND2
39.5GATA4, HAND1, HAND2

Compounds for genes affiliated with Congenital Heart Disease

About this section

GO Terms for genes affiliated with Congenital Heart Disease

About this section

Biological processes related to Congenital Heart Disease according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cardiac right ventricle formationGO:00032199.9HAND2, HAND1
2cartilage morphogenesisGO:00605369.8HAND1, HAND2
3determination of left/right symmetryGO:00073689.8ZIC3, CFC1
4odontogenesis of dentin-containing toothGO:00424759.8HAND1, HAND2
5negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.5HAND1, HAND2
6heart loopingGO:00019479.4GATA4, ZIC3, HAND1, HAND2
7positive regulation of transcription from RNA polymerase II promoterGO:00459449.3HAND2, HAND1, ZIC3, GATA4

Molecular functions related to Congenital Heart Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1activating transcription factor bindingGO:003361310.0GATA4, HAND2
2RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009779.8HAND2, GATA4
3transcription regulatory region DNA bindingGO:00442129.5GATA4, HAND1, HAND2
4transcription factor bindingGO:00081349.5GATA4, HAND1, HAND2
5transcription coactivator activityGO:00037139.2GATA4, HAND1, HAND2

Products for genes affiliated with Congenital Heart Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Congenital Heart Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet