MCID: CNG029
MIFTS: 48

Congenital Mesoblastic Nephroma malady

Rare diseases, Cancer diseases, Nephrological diseases categories
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Summaries for Congenital Mesoblastic Nephroma

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33MalaCards
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MalaCards: Congenital Mesoblastic Nephroma is related to mesoblastic nephroma and nephroblastoma. An important gene associated with Congenital Mesoblastic Nephroma is ETV6 (ets variant 6), and among its related pathways are Regulation of retinoblastoma protein and p70S6K Signaling. The compounds k252a and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Congenital Mesoblastic Nephroma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 35MeSH, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

congenital mesoblastic nephroma 8 43 10 49 62


External Ids:

Disease Ontology8 DOID:4773
MeSH35 D018201
NCIt40 C6569
ICD10 via Orphanet26 C64
SNOMED-CT via Orphanet59 11793003, 307604008
UMLS via Orphanet63 C1332965
MESH via Orphanet36 D018201

Related Diseases for Congenital Mesoblastic Nephroma

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17GeneCards, 18GeneDecks
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Diseases in the Adult Mesoblastic Nephroma family:

congenital mesoblastic nephroma Mesoblastic Nephroma

Diseases related to Congenital Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1mesoblastic nephroma32.1WT1, ETV6, IGF2
2nephroblastoma30.6WT1
3wilms tumor30.6IGF2, SMARCB1, KMT2A, VIM, REN, WT1
4clear cell sarcoma30.6IGF2, WT1
5hemihypertrophy30.6IGF2, WT1
6fibrosarcoma30.6MDM2, NTRK3, ETV6, VIM
7beckwith-wiedemann syndrome30.5IGF2, WT1, CTCF
8sarcoma30.5IGF2, SMARCB1, VIM, ETV6, MDM2, WT1
9cellular congenital mesoblastic nephroma10.9
10hypercalcemia10.7
11classic congenital mesoblastic nephroma10.6
12polyhydramnios10.6
13hypertension10.6
14nephrocalcinosis10.5
15renal hypertension10.5
16hydrops fetalis10.5
17hypertrophic pyloric stenosis10.3
18disseminated intravascular coagulation10.3
19leiomyoma10.3
20oligohydramnios10.3
21pyloric stenosis10.3
22metanephric adenoma10.1WT1
23congenital fibrosarcoma10.1ETV6
24giant cell glioblastoma10.1MDM2
25embryonal rhabdomyosarcoma10.1IGF2, WT1
26silver-russell syndrome10.1IGF2, CTCF
27acute myelomonocytic leukemia10.1ETV6, KMT2A
28phyllode tumor10.1VIM, IGF2
29adenomatoid tumor10.1VIM, WT1
30sex cord-gonadal stromal tumor10.1WT1, VIM
31alveolar rhabdomyosarcoma10.1WT1, MDM2
32smooth muscle tumor10.1IGF2, VIM
33abrikosov's tumor10.1VIM, WT1
34leukemia, acute lymphoblastic 310.1ETV6, KMT2A
35addison's disease10.0REN, WT1
36chondrosarcoma10.0MDM2, VIM
37adrenal adenoma10.0REN, IGF2
38precursor t-cell acute lymphoblastic leukemia10.0KMT2A, ETV6, WT1
39hematologic cancer10.0WT1, ETV6, KMT2A
40myelodysplastic syndromes10.0WT1, ETV6, KMT2A
41malignant peripheral nerve sheath tumor10.0VIM, MDM2
42epithelioid sarcoma10.0VIM, SMARCB1
43glomerulosclerosis10.0WT1, REN
44chronic kidney failure10.0IGF2, REN, WT1
45malignant fibroxanthoma10.0VIM, MDM2
46ependymoma10.0MDM2, VIM
47acute lymphocytic leukemia10.0KMT2A, ETV6, WT1
48liposarcoma10.0VIM, MDM2
49acute lymphoblastic leukemia, childhood10.0MDM2, ETV6, KMT2A
50spindle cell sarcoma10.0VIM, NTRK3

Graphical network of the top 20 diseases related to Congenital Mesoblastic Nephroma:



Diseases related to congenital mesoblastic nephroma

Symptoms for Congenital Mesoblastic Nephroma

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Drugs & Therapeutics for Congenital Mesoblastic Nephroma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Congenital Mesoblastic Nephroma

Search NIH Clinical Center for Congenital Mesoblastic Nephroma

Genetic Tests for Congenital Mesoblastic Nephroma

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Anatomical Context for Congenital Mesoblastic Nephroma

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33MalaCards
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MalaCards organs/tissues related to Congenital Mesoblastic Nephroma:

33
Kidney, Brain, Liver

Animal Models for Congenital Mesoblastic Nephroma or affiliated genes

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37MGI
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Publications for Congenital Mesoblastic Nephroma

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52PubMed
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Articles related to Congenital Mesoblastic Nephroma:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. (22236896)
2012
2
Cellular congenital mesoblastic nephroma: case report. (21541470)
2011
3
Pathology in practice. Congenital mesoblastic nephroma. (21961632)
2011
4
Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma. (21161280)
2011
5
Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (20455206)
2010
6
Congenital mesoblastic nephroma. (20096866)
2010
7
Imaging of congenital mesoblastic nephroma with pathological correlation. (19629463)
2009
8
Congenital mesoblastic nephroma rich from mitosis after in vitro fertilization: a case report. (18485932)
2008
9
WT1 expression and hemihypertrophy in congenital mesoblastic nephroma. (19011477)
2008
10
Congenital mesoblastic nephroma presenting with massive hematuria and hemorrhagic shock: report of one case. (17078466)
2006
11
Congenital mesoblastic nephroma presenting with neonatal hypertension. (15858607)
2005
12
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
13
Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. (14634980)
2003
14
Use of sarcoma-based chemotherapy in a case of congenital mesoblastic nephroma with liver metastases. (12809924)
2003
15
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)
2001
16
Cytogenetic and molecular characterization of a congenital mesoblastic nephroma. (11441343)
2001
17
Hyperreninemia and congenital mesoblastic nephroma: case report and review of the literature. (10792110)
2000
18
Congenital mesoblastic nephroma: A rare cause of perinatal anemia. (9931540)
1999
19
Congenital mesoblastic nephroma (CMN) with an unusual immunohistochemical feature. (10371751)
1999
20
Congenital mesoblastic nephroma: other magnetic resonance imaging findings. (10901975)
1999
21
Congenital mesoblastic nephroma. (9361489)
1997
22
Classical congenital mesoblastic nephroma in an adult: a case report on an Ethiopian. (10214440)
1997
23
Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. (9302166)
1997
24
A novel reciprocal translocation (14;15)(q11;q24) in a congenital mesoblastic nephroma. (8630977)
1996
25
Ultrastructure of cellular congenital mesoblastic nephroma. (8883325)
1996
26
The congenital mesoblastic nephroma: a case report of prenatal diagnosis. (8719724)
1996
27
Congenital mesoblastic nephroma associated with focal and segmental sclerosis. (8587629)
1995
28
Insulin-like growth factor II gene expression by congenital mesoblastic nephroma. (8634785)
1995
29
Presence or absence of trisomy 11 is correlated with histologic subtype in congenital mesoblastic nephroma. (7923083)
1994
30
Congenital mesoblastic nephroma: an immunohistochemical and lectin study. (8387953)
1993
31
Congenital mesoblastic nephroma: cytogenetic comparison to leiomyoma. (8396768)
1993
32
Nucleolar organizer regions in congenital mesoblastic nephroma. (1333074)
1992
33
Preoperative chemotherapy of cellular congenital mesoblastic nephroma in a 5-month-old infant. (1281666)
1992
34
Congenital mesoblastic nephroma, hemorrhagic shock, and disseminated intravascular coagulation in a newborn infant. (1851423)
1991
35
Congenital mesoblastic nephroma occurring in a solitary kidney. (2157574)
1990
36
Congenital mesoblastic nephroma: report of a case. (2556493)
1989
37
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction. (2546131)
1989
38
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
39
Two chromosomally different cell populations in a partly cellular congenital mesoblastic nephroma. (3030229)
1987
40
Congenital mesoblastic nephroma study of 7 cases--report of a case of atypical mesoblastic nephroma. (2820867)
1986
41
Calcification and ossification in a congenital mesoblastic nephroma. (3000046)
1985
42
Cellular congenital mesoblastic nephroma in a newborn. (6097889)
1984
43
Prenatal sonographic detection of congenital mesoblastic nephroma in a monozygotic twin pregnancy. (6317883)
1983
44
Congenital mesoblastic nephroma: relationship to other renal tumors of infancy. (6270389)
1981
45
Congenital mesoblastic nephroma presenting with primary reninism. (221639)
1979
46
Congenital mesoblastic nephroma. (189563)
1976
47
The management of benign renal tumors of infancy. Case report of a congenital mesoblastic nephroma (leiomyomatous hamartoma). (168170)
1975
48
Congenital mesoblastic nephroma of infancy. (164787)
1975
49
Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior. (4357122)
1973
50
Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms' tumor. (4378178)
1967

Variations for Congenital Mesoblastic Nephroma

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Expression for genes affiliated with Congenital Mesoblastic Nephroma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Mesoblastic Nephroma

Search GEO for disease gene expression data for Congenital Mesoblastic Nephroma.

Pathways for genes affiliated with Congenital Mesoblastic Nephroma

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG
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Pathways related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SMARCB1, MDM2
2
Show member pathways
9.4IGF2, REN, NTRK3
3
Show member pathways
8.7IGF2, VIM, NTRK3, MDM2
48.0KMT2A, ETV6, SSX2B, MDM2, WT1

Compounds for genes affiliated with Congenital Mesoblastic Nephroma

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45Novoseek, 29IUPHAR, 11DrugBank, 3BitterDB, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1k252a459.8VIM, NTRK3
22-methoxyethanol459.8VIM, IGF2
3b 723459.8VIM, WT1
4p00001459.7KMT2A, MDM2
5prednisolone45 29 1111.7ETV6, KMT2A, IGF2
6n-(4-hydroxyphenyl)retinamide459.5IGF2, VIM
7chloramphenicol45 3 51 1112.4WT1, VIM, IGF2
8hydrocortisone45 3 61 1112.4IGF2, VIM, REN
9gefitinib45 51 1111.4MDM2, VIM, IGF2
10butyrate459.3WT1, VIM, IGF2
11valine459.3MDM2, VIM, IGF2
12vitamin d459.3IGF2, VIM, WT1
13indomethacin45 29 61 1112.3REN, VIM, IGF2
14calcitriol45 61 24 1112.2WT1, REN, KMT2A, IGF2
15paclitaxel45 51 1111.2MDM2, VIM, IGF2
16agar459.2IGF2, VIM, ETV6, MDM2
17imatinib45 51 1111.2IGF2, ETV6, NTRK3, MDM2, WT1
18rapamycin459.1IGF2, VIM, MDM2
19threonine459.1WT1, MDM2, NTRK3, KMT2A
20forskolin45 51 1111.1WT1, REN, VIM, IGF2
21roscovitine459.1VIM, MDM2
22glycogen45 2410.1MDM2, VIM, IGF2
23creatinine459.1IGF2, VIM, REN, WT1
24paraffin459.1IGF2, VIM, MDM2, WT1
25cycloheximide459.1IGF2, VIM, NTRK3, MDM2
26estradiol45 24 1111.0MDM2, REN, VIM, IGF2
27progesterone45 29 61 24 1113.0IGF2, VIM, MDM2, WT1
28steroid459.0IGF2, REN, MDM2, WT1, CTCF
29vincristine45 51 1111.0WT1, MDM2, VIM, KMT2A
30doxorubicin45 51 1110.9KMT2A, VIM, MDM2, WT1
31aspartate458.9KMT2A, VIM, NTRK3, MDM2
32dexamethasone45 51 29 1111.9IGF2, VIM, REN, MDM2
33actinomycin d458.9IGF2, KMT2A, VIM, MDM2
34genistein45 29 61 3 24 1113.9MDM2, VIM, KMT2A
35zinc45 249.9IGF2, KMT2A, MDM2, WT1, CTCF
36testosterone45 61 24 1111.8WT1, MDM2, NTRK3, VIM, IGF2
37proline458.7KMT2A, VIM, NTRK3, MDM2, WT1
385-aza-2deoxycytidine458.6IGF2, KMT2A, VIM, MDM2, CTCF
39etoposide45 51 61 1111.6IGF2, KMT2A, VIM, MDM2, WT1
40cysteine458.6WT1, MDM2, VIM, IGF2
41tyrosine458.6IGF2, KMT2A, ETV6, NTRK3, MDM2, WT1
42oligonucleotide458.6IGF2, KMT2A, VIM, MDM2, WT1
43estrogen458.5IGF2, KMT2A, VIM, MDM2, WT1
44retinoic acid45 249.5IGF2, KMT2A, VIM, ETV6, NTRK3, WT1
45serine458.2IGF2, KMT2A, VIM, MDM2, WT1, CTCF
46arginine458.2IGF2, KMT2A, VIM, REN, MDM2, WT1
47vegf458.1WT1, MDM2, NTRK3, REN, ETV6, VIM

GO Terms for genes affiliated with Congenital Mesoblastic Nephroma

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16Gene Ontology
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Cellular components related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.8SMARCB1, MDM2, WT1, CTCF
2nucleolusGO:0057307.7SMARCB1, KMT2A, ETV6, MDM2, WT1, CTCF

Biological processes related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of gene expression by genetic imprintingGO:0063499.8CTCF, IGF2
2positive regulation of gene expressionGO:0106289.5NTRK3, MDM2, CTCF
3negative regulation of cell proliferationGO:0082859.1KMT2A, WT1, SMARCB1
4regulation of transcription from RNA polymerase II promoterGO:0063579.0SMARCB1, ETV6, WT1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.6SMARCB1, KMT2A, WT1, IGF2

Molecular functions related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.7REN, IGF2
2p53 bindingGO:0020399.3MDM2, NTRK3, SMARCB1
3transcription regulatory region DNA bindingGO:0442129.2KMT2A, WT1, CTCF
4scaffold protein bindingGO:0971109.1MDM2, VIM
5sequence-specific DNA binding transcription factor activityGO:0037009.0CTCF, WT1, ETV6, KMT2A
6protein bindingGO:0055156.3IGF2, SMARCB1, KMT2A, VIM, ETV6, SSX2B

Products for genes affiliated with Congenital Mesoblastic Nephroma

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Sources for Congenital Mesoblastic Nephroma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet