MCID: CNG029
MIFTS: 41

Congenital Mesoblastic Nephroma malady

Rare diseases, Nephrological diseases, Cancer diseases categories

Summaries for Congenital Mesoblastic Nephroma

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MalaCards based summary: Congenital Mesoblastic Nephroma is related to mesoblastic nephroma and wilms tumor. An important gene associated with Congenital Mesoblastic Nephroma is ETV6 (ets variant 6), and among its related pathways are Regulation of retinoblastoma protein and p70S6K Signaling. The compounds k252a and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Congenital Mesoblastic Nephroma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Congenital Mesoblastic Nephroma, Aliases & Descriptions:

Name: Congenital Mesoblastic Nephroma 9 41 11 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:4773
MeSH33 D018201
NCIt38 C6569
Orphanet47 2665
MESH via Orphanet34 D018201
ICD10 via Orphanet26 C64
UMLS via Orphanet61 C1332965

Related Diseases for Congenital Mesoblastic Nephroma

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Diseases in the Mesoblastic Nephroma family:

Adult Mesoblastic Nephroma congenital mesoblastic nephroma

Diseases related to Congenital Mesoblastic Nephroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1mesoblastic nephroma32.4WT1, ETV6, IGF2
2wilms tumor31.5WT1
3clear cell sarcoma31.0IGF2, WT1
4beckwith-wiedemann syndrome30.8IGF2, WT1, CTCF
5fibrosarcoma30.2MDM2, NTRK3, ETV6, VIM
6sarcoma29.9IGF2, SMARCB1, VIM, ETV6, MDM2, WT1
7cellular congenital mesoblastic nephroma10.9
8hypercalcemia10.7
9classic congenital mesoblastic nephroma10.7
10polyhydramnios10.6
11metanephric adenoma10.5WT1
12nephrocalcinosis10.5
13renal hypertension10.5
14hydrops fetalis10.5
15congenital fibrosarcoma10.5ETV6
16giant cell glioblastoma10.4MDM2
17hemi 3 syndrome10.3IGF2, WT1
18embryonal rhabdomyosarcoma10.3IGF2, WT1
19silver-russell syndrome10.3IGF2, CTCF
20hypertrophic pyloric stenosis10.3
21disseminated intravascular coagulation10.3
22leiomyoma10.3
23oligohydramnios10.3
24pyloric stenosis10.3
25acute myelomonocytic leukemia10.3ETV6, KMT2A
26benign breast phyllodes tumor10.3VIM, IGF2
27adrenal adenoma10.3IGF2, REN
28adenomatoid tumor10.3VIM, WT1
29sex cord-gonadal stromal tumor10.3WT1, VIM
30rhabdomyosarcoma 2, alveolar10.3WT1, MDM2
31smooth muscle tumor10.2IGF2, VIM
32abrikosov's tumor10.2VIM, WT1
33precursor b-cell acute lymphoblastic leukemia10.2ETV6, KMT2A
34addison's disease10.2REN, WT1
35chondrosarcoma10.2MDM2, VIM
36chromosomal triplication10.2CTCF, ETV6, KMT2A
37adrenal cortical adenoma10.2REN, IGF2
38precursor t-cell acute lymphoblastic leukemia10.2KMT2A, ETV6, WT1
39hematologic cancer10.2WT1, ETV6, KMT2A
40myelodysplastic syndrome10.2WT1, ETV6, KMT2A
41malignant peripheral nerve sheath tumor10.1VIM, MDM2
42epithelioid sarcoma10.1VIM, SMARCB1
43glomerulosclerosis10.1WT1, REN
44chronic kidney failure10.1IGF2, REN, WT1
45malignant fibroxanthoma10.1VIM, MDM2
46ependymoma10.1MDM2, VIM
47leukemia, acute lymphoblastic10.1KMT2A, ETV6, WT1
48liposarcoma10.1VIM, MDM2
49acute lymphoblastic leukemia, childhood10.1MDM2, ETV6, KMT2A
50spindle cell sarcoma10.1VIM, NTRK3

Graphical network of the top 20 diseases related to Congenital Mesoblastic Nephroma:



Diseases related to congenital mesoblastic nephroma

Symptoms for Congenital Mesoblastic Nephroma

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Drugs & Therapeutics for Congenital Mesoblastic Nephroma

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Drug clinical trials:

Search ClinicalTrials for Congenital Mesoblastic Nephroma

Search NIH Clinical Center for Congenital Mesoblastic Nephroma

Genetic Tests for Congenital Mesoblastic Nephroma

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Anatomical Context for Congenital Mesoblastic Nephroma

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MalaCards organs/tissues related to Congenital Mesoblastic Nephroma:

31
Kidney, Brain, Liver

Animal Models for Congenital Mesoblastic Nephroma or affiliated genes

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Publications for Congenital Mesoblastic Nephroma

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Articles related to Congenital Mesoblastic Nephroma:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Congenital mesoblastic nephroma with focal anaplastic lesion. (25818639)
2015
2
Congenital mesoblastic nephroma in a premature neonate: a case report and review of literature. (24553043)
2014
3
AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. (22236896)
2012
4
Cellular congenital mesoblastic nephroma: case report. (21541470)
2011
5
Pathology in practice. Congenital mesoblastic nephroma. (21961632)
2011
6
Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma. (21161280)
2011
7
Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (20455206)
2010
8
Congenital mesoblastic nephroma. (20096866)
2010
9
Imaging of congenital mesoblastic nephroma with pathological correlation. (19629463)
2009
10
WT1 expression and hemihypertrophy in congenital mesoblastic nephroma. (19011477)
2008
11
Congenital mesoblastic nephroma presenting with massive hematuria and hemorrhagic shock: report of one case. (17078466)
2006
12
Congenital mesoblastic nephroma presenting with neonatal hypertension. (15858607)
2005
13
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
14
Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. (14634980)
2003
15
Use of sarcoma-based chemotherapy in a case of congenital mesoblastic nephroma with liver metastases. (12809924)
2003
16
Multicystic congenital mesoblastic nephroma. (11927972)
2002
17
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)
2001
18
Cytogenetic and molecular characterization of a congenital mesoblastic nephroma. (11441343)
2001
19
Hyperreninemia and congenital mesoblastic nephroma: case report and review of the literature. (10792110)
2000
20
Congenital mesoblastic nephroma: A rare cause of perinatal anemia. (9931540)
1999
21
Congenital mesoblastic nephroma (CMN) with an unusual immunohistochemical feature. (10371751)
1999
22
Congenital mesoblastic nephroma: other magnetic resonance imaging findings. (10901975)
1999
23
Congenital mesoblastic nephroma. (9361489)
1997
24
Classical congenital mesoblastic nephroma in an adult: a case report on an Ethiopian. (10214440)
1997
25
Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. (9302166)
1997
26
A novel reciprocal translocation (14;15)(q11;q24) in a congenital mesoblastic nephroma. (8630977)
1996
27
Ultrastructure of cellular congenital mesoblastic nephroma. (8883325)
1996
28
The congenital mesoblastic nephroma: a case report of prenatal diagnosis. (8719724)
1996
29
Congenital mesoblastic nephroma associated with focal and segmental sclerosis. (8587629)
1995
30
Presence or absence of trisomy 11 is correlated with histologic subtype in congenital mesoblastic nephroma. (7923083)
1994
31
Congenital mesoblastic nephroma: an immunohistochemical and lectin study. (8387953)
1993
32
Congenital mesoblastic nephroma: cytogenetic comparison to leiomyoma. (8396768)
1993
33
Nucleolar organizer regions in congenital mesoblastic nephroma. (1333074)
1992
34
Preoperative chemotherapy of cellular congenital mesoblastic nephroma in a 5-month-old infant. (1281666)
1992
35
Congenital mesoblastic nephroma, hemorrhagic shock, and disseminated intravascular coagulation in a newborn infant. (1851423)
1991
36
Congenital mesoblastic nephroma occurring in a solitary kidney. (2157574)
1990
37
Congenital mesoblastic nephroma: report of a case. (2556493)
1989
38
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction. (2546131)
1989
39
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
40
Two chromosomally different cell populations in a partly cellular congenital mesoblastic nephroma. (3030229)
1987
41
Congenital mesoblastic nephroma study of 7 cases--report of a case of atypical mesoblastic nephroma. (2820867)
1986
42
Calcification and ossification in a congenital mesoblastic nephroma. (3000046)
1985
43
Cellular congenital mesoblastic nephroma in a newborn. (6097889)
1984
44
Prenatal sonographic detection of congenital mesoblastic nephroma in a monozygotic twin pregnancy. (6317883)
1983
45
Congenital mesoblastic nephroma presenting with primary reninism. (221639)
1979
46
Congenital mesoblastic nephroma. (189563)
1976
47
The management of benign renal tumors of infancy. Case report of a congenital mesoblastic nephroma (leiomyomatous hamartoma). (168170)
1975
48
Congenital mesoblastic nephroma of infancy. (164787)
1975
49
Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior. (4357122)
1973
50
Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms' tumor. (4378178)
1967

Variations for Congenital Mesoblastic Nephroma

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Expression for genes affiliated with Congenital Mesoblastic Nephroma

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Search GEO for disease gene expression data for Congenital Mesoblastic Nephroma.

Pathways for genes affiliated with Congenital Mesoblastic Nephroma

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Pathways related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, SMARCB1
2
Show member pathways
9.4IGF2, REN, NTRK3
3
Show member pathways
8.7MDM2, NTRK3, VIM, IGF2
48.0WT1, MDM2, SSX2B, ETV6, KMT2A

Compounds for genes affiliated with Congenital Mesoblastic Nephroma

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Compounds related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

(show all 47)
idCompoundScoreTop Affiliating Genes
1k252a439.8VIM, NTRK3
22-methoxyethanol439.8VIM, IGF2
3b 723439.8VIM, WT1
4p00001439.7KMT2A, MDM2
5prednisolone43 28 1211.7ETV6, KMT2A, IGF2
6n-(4-hydroxyphenyl)retinamide439.5IGF2, VIM
7chloramphenicol43 2 49 1212.4WT1, VIM, IGF2
8hydrocortisone43 2 59 1212.4IGF2, VIM, REN
9gefitinib43 49 1211.4MDM2, VIM, IGF2
10butyrate439.3WT1, VIM, IGF2
11valine439.3MDM2, VIM, IGF2
12vitamin d439.3IGF2, VIM, WT1
13indomethacin43 28 59 1212.3REN, VIM, IGF2
14calcitriol43 59 24 1212.2WT1, REN, KMT2A, IGF2
15paclitaxel43 49 1211.2MDM2, VIM, IGF2
16agar439.2IGF2, VIM, ETV6, MDM2
17imatinib43 49 1211.2IGF2, ETV6, NTRK3, MDM2, WT1
18rapamycin439.1IGF2, VIM, MDM2
19threonine439.1WT1, MDM2, NTRK3, KMT2A
20forskolin43 49 1211.1WT1, REN, VIM, IGF2
21roscovitine439.1VIM, MDM2
22glycogen43 2410.1MDM2, VIM, IGF2
23creatinine439.1IGF2, VIM, REN, WT1
24paraffin439.1IGF2, VIM, MDM2, WT1
25cycloheximide439.1IGF2, VIM, NTRK3, MDM2
26estradiol43 24 1211.0MDM2, REN, VIM, IGF2
27progesterone43 28 59 24 1213.0IGF2, VIM, MDM2, WT1
28steroid439.0IGF2, REN, MDM2, WT1, CTCF
29vincristine43 49 1211.0WT1, MDM2, VIM, KMT2A
30doxorubicin43 49 1210.9KMT2A, VIM, MDM2, WT1
31aspartate438.9KMT2A, VIM, NTRK3, MDM2
32dexamethasone43 49 28 1211.9IGF2, VIM, REN, MDM2
33actinomycin d438.9IGF2, KMT2A, VIM, MDM2
34genistein43 28 59 2 24 1213.9MDM2, VIM, KMT2A
35zinc43 249.9IGF2, KMT2A, MDM2, WT1, CTCF
36testosterone43 59 24 1211.8WT1, MDM2, NTRK3, VIM, IGF2
37proline438.7KMT2A, VIM, NTRK3, MDM2, WT1
385-aza-2deoxycytidine438.6IGF2, KMT2A, VIM, MDM2, CTCF
39etoposide43 49 59 1211.6IGF2, KMT2A, VIM, MDM2, WT1
40cysteine438.6WT1, MDM2, VIM, IGF2
41tyrosine438.6IGF2, KMT2A, ETV6, NTRK3, MDM2, WT1
42oligonucleotide438.6IGF2, KMT2A, VIM, MDM2, WT1
43estrogen438.5IGF2, KMT2A, VIM, MDM2, WT1
44retinoic acid43 249.5IGF2, KMT2A, VIM, ETV6, NTRK3, WT1
45serine438.2IGF2, KMT2A, VIM, MDM2, WT1, CTCF
46arginine438.2IGF2, KMT2A, VIM, REN, MDM2, WT1
47vegf438.1WT1, MDM2, NTRK3, REN, ETV6, VIM

GO Terms for genes affiliated with Congenital Mesoblastic Nephroma

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Cellular components related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.8CTCF, WT1, MDM2, SMARCB1
2nucleolusGO:00057307.7CTCF, SMARCB1, KMT2A, ETV6, MDM2, WT1

Biological processes related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of gene expression by genetic imprintingGO:00063499.8CTCF, IGF2
2positive regulation of gene expressionGO:00106289.5CTCF, MDM2, NTRK3
3negative regulation of cell proliferationGO:00082859.1WT1, KMT2A, SMARCB1
4regulation of transcription from RNA polymerase II promoterGO:00063579.0WT1, ETV6, SMARCB1
5positive regulation of transcription from RNA polymerase II promoterGO:00459448.6IGF2, SMARCB1, KMT2A, WT1

Molecular functions related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00051599.7REN, IGF2
2p53 bindingGO:00020399.3MDM2, NTRK3, SMARCB1
3transcription regulatory region DNA bindingGO:00442129.2KMT2A, WT1, CTCF
4scaffold protein bindingGO:00971109.1MDM2, VIM
5sequence-specific DNA binding transcription factor activityGO:00037009.0CTCF, WT1, ETV6, KMT2A
6protein bindingGO:00055156.3IGF2, SMARCB1, KMT2A, VIM, ETV6, SSX2B

Products for genes affiliated with Congenital Mesoblastic Nephroma

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Sources for Congenital Mesoblastic Nephroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet