MCID: CNG029
MIFTS: 38

Congenital Mesoblastic Nephroma malady

Summaries for Congenital Mesoblastic Nephroma

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33MalaCards
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MalaCards: Congenital Mesoblastic Nephroma is related to mesoblastic nephroma and wilms tumor. An important gene associated with Congenital Mesoblastic Nephroma is ETV6 (ets variant 6), and among its related pathways is Transcriptional misregulation in cancer. The compounds estrogen and 2-methoxyethanol have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Congenital Mesoblastic Nephroma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
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Classifications:



Aliases & Descriptions:

congenital mesoblastic nephroma 8 43 10 49 61


External Ids:

Disease Ontology8 DOID:4773
NCIt40 C6569
MeSH35 D018201
ICD10 via Orphanet26 C64
SNOMED-CT via Orphanet58 11793003, 307604008
UMLS via Orphanet62 C1332965
MESH via Orphanet36 D018201

Related Diseases for Congenital Mesoblastic Nephroma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the adult mesoblastic nephroma family:

congenital mesoblastic nephroma mesoblastic nephroma

Diseases related to Congenital Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1mesoblastic nephroma32.0ETV6, IGF2, WT1
2wilms tumor30.7VIM, WT1, CTCF, IGF2, REN, KMT2A
3congenital fibrosarcoma30.7ETV6
4clear cell sarcoma30.4WT1, IGF2
5hemihypertrophy30.4WT1, IGF2
6beckwith-wiedemann syndrome30.4IGF2, CTCF, WT1
7cellular congenital mesoblastic nephroma10.9
8classic congenital mesoblastic nephroma10.7
9hypercalcemia10.7
10adult mesoblastic nephroma10.6
11polyhydramnios10.6
12nephrocalcinosis10.5
13n syndrome10.5
14hydrops fetalis10.5
15cystic nephroma10.3
16kidney clear cell sarcoma10.3
17hypertrophic pyloric stenosis10.3
18nephroblastoma10.0WT1
19benign mesothelioma10.0WT1
20metanephric adenoma10.0WT1
21hyperandrogenism10.0IGF2
22wagr syndrome10.0WT1
23uterine sarcoma10.0MDM2
24liver cirrhosis10.0REN
25giant cell glioblastoma10.0MDM2
26atypical teratoid rhabdoid tumor10.0SMARCB1
27eosinophilia10.0ETV6
28sertoli-leydig cell tumor10.0WT1
29eye disease10.0MDM2
30rhabdoid cancer10.0SMARCB1
31oligodendroglioma10.0MDM2
32neurilemmoma10.0SMARCB1
33monocytic leukemia10.0KMT2A
34ataxia telangiectasia10.0MDM2
35pancreatic cancer10.0NTRK3
36collecting duct carcinoma10.0SMARCB1
37primary hyperoxaluria10.0REN, WT1
38embryonal rhabdomyosarcoma10.0WT1, IGF2
39alveolar rhabdomyosarcoma10.0MDM2, WT1
40chordoma10.0VIM
41adenoma10.0REN, IGF2
42angiosarcoma10.0VIM
43acute myelomonocytic leukemia10.0ETV6, KMT2A
44glioblastoma multiforme10.0SMARCB1, MDM2
45benign meningioma10.0MDM2
46sertoli cell tumor10.0VIM
47smooth muscle tumor10.0VIM, IGF2
48chondrosarcoma10.0MDM2, VIM
49phyllode tumor10.0VIM, IGF2
50ependymoma10.0MDM2, VIM

Graphical network of the top 20 diseases related to Congenital Mesoblastic Nephroma:



Diseases related to congenital mesoblastic nephroma

Clinical Features for Congenital Mesoblastic Nephroma

Drugs & Therapeutics for Congenital Mesoblastic Nephroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Mesoblastic Nephroma

Drug clinical trials:

Search ClinicalTrials for Congenital Mesoblastic Nephroma

Search NIH Clinical Center for Congenital Mesoblastic Nephroma

Search CenterWatch for Congenital Mesoblastic Nephroma

Genetic Tests for Congenital Mesoblastic Nephroma

Anatomical Context for Congenital Mesoblastic Nephroma

Animal Models for Congenital Mesoblastic Nephroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Congenital Mesoblastic Nephroma

Sources:
51PubMed
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Articles related to Congenital Mesoblastic Nephroma:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Maternal manifestation of Ballantyne's syndrome occurring concomitantly with the development of fetal congenital mesoblastic nephroma. (24428571)
2014
2
Prenatal diagnosis of congenital mesoblastic nephroma. (22354312)
2013
3
Congenital mesoblastic nephroma: A rare cause of recurrent hematuria beyond infancy. (23960358)
2013
4
Pathology in practice. Congenital mesoblastic nephroma. (21961632)
2011
5
Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology. (21075369)
2011
6
Regression of a congenital mesoblastic nephroma. (20582939)
2010
7
Imaging of congenital mesoblastic nephroma with pathological correlation. (19629463)
2009
8
Congenital collision tumors, neonatal renal mesoblastic nephroma and pararenal paraganglioma. (19784003)
2009
9
Congenital mesoblastic nephroma rich from mitosis after in vitro fertilization: a case report. (18485932)
2008
10
Expression of ETV6-NTRK in classical, cellular and mixed subtypes of congenital mesoblastic nephroma. (16681692)
2006
11
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (15711357)
2005
12
Cellular congenital mesoblastic nephroma with contralateral medullary nephrocalcinosis. (15121709)
2004
13
Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. (14634980)
2003
14
Multicystic congenital mesoblastic nephroma. (11927972)
2002
15
Cryptic t(12;15)(p13;q26) producing the ETV6-NTRK3 fusion gene and no loss of IGF2 imprinting in congenital mesoblastic nephroma with trisomy 11: fluorescence in situ hybridization and IGF2 allelic expression analysis. (12165445)
2002
16
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)
2001
17
Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma. (11381370)
2001
18
Hyperreninemia and congenital mesoblastic nephroma: case report and review of the literature. (10792110)
2000
19
Congenital mesoblastic nephroma: report of a Case with review of the most significant literature. (10729925)
2000
20
Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. (10658907)
2000
21
Congenital mesoblastic nephroma: A rare cause of perinatal anemia. (9931540)
1999
22
Congenital mesoblastic nephroma (CMN) with an unusual immunohistochemical feature. (10371751)
1999
23
Congenital mesoblastic nephroma and trisomy 11. (9595049)
1998
24
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. (9823307)
1998
25
Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. (9302166)
1997
26
Congenital mesoblastic nephroma associated with focal and segmental sclerosis. (8587629)
1995
27
Congenital mesoblastic nephroma: cytogenetic comparison to leiomyoma. (8396768)
1993
28
Nucleolar organizer regions in congenital mesoblastic nephroma. (1333074)
1992
29
Cytologic characteristics of congenital mesoblastic nephroma in fine-needle aspiration cytology: a case report. (1322264)
1992
30
Pediatric case of the day. Congenital mesoblastic nephroma. (1653445)
1991
31
Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content. (1851500)
1991
32
Adult variant of congenital mesoblastic nephroma. (2185715)
1990
33
Congenital mesoblastic nephroma, renin production, and hypertension. (2544716)
1989
34
Hydramnios associated with congenital mesoblastic nephroma: case report. (2548137)
1989
35
Congenital mesoblastic nephroma in a dog: a benign variant of nephroblastoma. (2548317)
1989
36
Cellular congenital mesoblastic nephroma: what are the options. (2545932)
1989
37
Renin messenger RNA localization in congenital mesoblastic nephroma using in situ hybridization. (2551958)
1989
38
Congenital mesoblastic nephroma study of 7 cases--report of a case of atypical mesoblastic nephroma. (2820867)
1986
39
Prenatal diagnosis of a congenital mesoblastic nephroma. A case report. (3012082)
1986
40
Congenital mesoblastic nephroma of infancy. (3035027)
1986
41
Congenital mesoblastic nephroma with hypercalcemia. Pathogenetic role of prostaglandins. (3017143)
1986
42
Congenital mesoblastic nephroma of infancy associated with hypercalcemia. (3007779)
1986
43
Prenatal sonographic detection of congenital mesoblastic nephroma in a monozygotic twin pregnancy. (6317883)
1983
44
Congenital mesoblastic nephroma: relationship to other renal tumors of infancy. (6270389)
1981
45
Congenital mesoblastic nephroma with cystic component. (6268664)
1981
46
Congenital cystic mesoblastic nephroma. (7319492)
1981
47
Congenital mesoblastic nephroma presenting with primary reninism. (221639)
1979
48
Congenital mesoblastic nephroma of infancy. (189732)
1976
49
The management of benign renal tumors of infancy. Case report of a congenital mesoblastic nephroma (leiomyomatous hamartoma). (168170)
1975
50
Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior. (4357122)
1973

Genetic Variations for Congenital Mesoblastic Nephroma

Expression for genes affiliated with Congenital Mesoblastic Nephroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Mesoblastic Nephroma

Search GEO for disease gene expression data for Congenital Mesoblastic Nephroma.

Pathways for genes affiliated with Congenital Mesoblastic Nephroma

Sources:
30KEGG
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Pathways related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.5KMT2A, ETV6, SSX2B, MDM2, WT1

Compounds for genes affiliated with Congenital Mesoblastic Nephroma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 24HMDB
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Compounds related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1estrogen4510.2KMT2A
22-methoxyethanol4510.0IGF2, VIM
3k252a459.7VIM, NTRK3
4gefitinib45 50 1111.7IGF2, MDM2, VIM
5prednisolone45 29 1111.7IGF2, ETV6, KMT2A
6p00001459.6KMT2A, MDM2
7hydrocortisone45 2 60 1112.6REN, IGF2, VIM
8valine459.5IGF2, MDM2, VIM
9agar459.5ETV6, IGF2, MDM2, VIM
10b 723459.4WT1, VIM
11imatinib45 50 1111.4ETV6, IGF2, NTRK3, MDM2, WT1
12paraffin459.4VIM, WT1, MDM2, IGF2
13calcitriol45 60 11 2412.3KMT2A, REN, IGF2, WT1
14forskolin45 50 1111.3REN, IGF2, WT1, VIM
15estradiol45 11 2411.3REN, IGF2, MDM2, VIM
16chloramphenicol45 2 1111.3IGF2, WT1, VIM
17vincristine45 50 1111.2KMT2A, MDM2, WT1, VIM
18creatinine459.2VIM, WT1, IGF2, REN
19cycloheximide459.2VIM, MDM2, NTRK3, IGF2
20steroid459.2REN, MDM2, CTCF, WT1
21doxorubicin45 50 1111.2KMT2A, MDM2, WT1, VIM
22actinomycin d459.2VIM, MDM2, IGF2, KMT2A
23testosterone45 60 11 2412.1VIM, WT1, MDM2, NTRK3, IGF2
24progesterone45 60 29 11 2413.1VIM, WT1, MDM2, IGF2
25aspartate459.0KMT2A, NTRK3, MDM2, VIM
26proline459.0VIM, WT1, MDM2, NTRK3, KMT2A
27etoposide45 50 60 1111.9VIM, WT1, MDM2, IGF2, KMT2A
28oligonucleotide458.9VIM, WT1, MDM2, IGF2, KMT2A
29zinc45 249.7WT1, CTCF, MDM2, IGF2, KMT2A
30retinoic acid45 249.7VIM, WT1, NTRK3, IGF2, ETV6, KMT2A
31tyrosine458.7WT1, MDM2, NTRK3, IGF2, ETV6, KMT2A
325-aza-2deoxycytidine458.6VIM, CTCF, MDM2, IGF2, KMT2A
33arginine458.5VIM, WT1, MDM2, IGF2, REN, KMT2A
34vegf458.5VIM, WT1, MDM2, NTRK3, IGF2, ETV6
35serine458.2VIM, WT1, CTCF, MDM2, IGF2, KMT2A

GO Terms for genes affiliated with Congenital Mesoblastic Nephroma

Sources:
16Gene Ontology
See all sources

Biological processes related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of gene expression by genetic imprintingGO:0063499.5IGF2, CTCF
2positive regulation of gene expressionGO:0106288.9NTRK3, MDM2, CTCF

Molecular functions related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.7IGF2, REN
2scaffold protein bindingGO:0971109.7MDM2, VIM
3p53 bindingGO:0020399.5SMARCB1, NTRK3, MDM2
4transcription regulatory region DNA bindingGO:0442128.7KMT2A, CTCF, WT1
5protein bindingGO:0055155.9VIM, WT1, CTCF, MDM2, PRUNE, SSX2B

Products for genes affiliated with Congenital Mesoblastic Nephroma

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  • Lysates
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Sources for Congenital Mesoblastic Nephroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet