MCID: CNG029
MIFTS: 48

Congenital Mesoblastic Nephroma malady

Rare diseases, Cancer diseases, Nephrological diseases categories
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Summaries for Congenital Mesoblastic Nephroma

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MalaCards based summary: Congenital Mesoblastic Nephroma is related to mesoblastic nephroma and nephroblastoma. An important gene associated with Congenital Mesoblastic Nephroma is ETV6 (ets variant 6), and among its related pathways are Regulation of retinoblastoma protein and p70S6K Signaling. The compounds k252a and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Congenital Mesoblastic Nephroma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Congenital Mesoblastic Nephroma, Aliases & Descriptions:

Name: Congenital Mesoblastic Nephroma 8 42 10 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:4773
MeSH34 D018201
NCIt39 C6569
MESH via Orphanet35 D018201
ICD10 via Orphanet26 C64
UMLS via Orphanet63 C1332965

Related Diseases for Congenital Mesoblastic Nephroma

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Diseases in the Congenital Mesoblastic Nephroma family:

Adult Mesoblastic Nephroma Mesoblastic Nephroma

Diseases related to Congenital Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1mesoblastic nephroma32.4WT1, ETV6, IGF2
2nephroblastoma31.1WT1
3clear cell sarcoma31.0IGF2, WT1
4hemihypertrophy31.0IGF2, WT1
5beckwith-wiedemann syndrome30.8IGF2, WT1, CTCF
6fibrosarcoma30.2MDM2, NTRK3, ETV6, VIM
7wilms tumor29.9IGF2, SMARCB1, KMT2A, VIM, REN, WT1
8sarcoma29.9IGF2, SMARCB1, VIM, ETV6, MDM2, WT1
9cellular congenital mesoblastic nephroma10.9
10hypercalcemia10.7
11hypertension10.6
12classic congenital mesoblastic nephroma10.6
13polyhydramnios10.6
14metanephric adenoma10.5WT1
15congenital fibrosarcoma10.5ETV6
16nephrocalcinosis10.5
17renal hypertension10.5
18hydrops fetalis10.5
19giant cell glioblastoma10.4MDM2
20embryonal rhabdomyosarcoma10.3IGF2, WT1
21silver-russell syndrome10.3IGF2, CTCF
22hypertrophic pyloric stenosis10.3
23disseminated intravascular coagulation10.3
24leiomyoma10.3
25oligohydramnios10.3
26pyloric stenosis10.3
27acute myelomonocytic leukemia10.3ETV6, KMT2A
28phyllode tumor10.3VIM, IGF2
29adrenal adenoma10.3IGF2, REN
30adenomatoid tumor10.3VIM, WT1
31sex cord-gonadal stromal tumor10.3WT1, VIM
32alveolar rhabdomyosarcoma10.3WT1, MDM2
33smooth muscle tumor10.2IGF2, VIM
34abrikosov's tumor10.2VIM, WT1
35leukemia, acute lymphoblastic 310.2ETV6, KMT2A
36addison's disease10.2REN, WT1
37chondrosarcoma10.2MDM2, VIM
38adrenal cortical adenoma10.2REN, IGF2
39precursor t-cell acute lymphoblastic leukemia10.2KMT2A, ETV6, WT1
40hematologic cancer10.2WT1, ETV6, KMT2A
41myelodysplastic syndromes10.2WT1, ETV6, KMT2A
42malignant peripheral nerve sheath tumor10.1VIM, MDM2
43epithelioid sarcoma10.1VIM, SMARCB1
44glomerulosclerosis10.1WT1, REN
45chronic kidney failure10.1IGF2, REN, WT1
46malignant fibroxanthoma10.1VIM, MDM2
47ependymoma10.1MDM2, VIM
48acute lymphoblastic leukemia10.1KMT2A, ETV6, WT1
49liposarcoma10.1VIM, MDM2
50acute lymphoblastic leukemia, childhood10.1MDM2, ETV6, KMT2A

Graphical network of the top 20 diseases related to Congenital Mesoblastic Nephroma:



Diseases related to congenital mesoblastic nephroma

Symptoms for Congenital Mesoblastic Nephroma

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Drugs & Therapeutics for Congenital Mesoblastic Nephroma

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Drug clinical trials:

Search ClinicalTrials for Congenital Mesoblastic Nephroma

Search NIH Clinical Center for Congenital Mesoblastic Nephroma

Genetic Tests for Congenital Mesoblastic Nephroma

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Anatomical Context for Congenital Mesoblastic Nephroma

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MalaCards organs/tissues related to Congenital Mesoblastic Nephroma:

32
Kidney, Brain, Liver

Animal Models for Congenital Mesoblastic Nephroma or affiliated genes

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Publications for Congenital Mesoblastic Nephroma

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Articles related to Congenital Mesoblastic Nephroma:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Congenital mesoblastic nephroma in a premature neonate: a case report and review of literature. (24553043)
2014
2
AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. (22236896)
2012
3
Cellular congenital mesoblastic nephroma: case report. (21541470)
2011
4
Pathology in practice. Congenital mesoblastic nephroma. (21961632)
2011
5
Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma. (21161280)
2011
6
Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (20455206)
2010
7
Congenital mesoblastic nephroma. (20096866)
2010
8
Imaging of congenital mesoblastic nephroma with pathological correlation. (19629463)
2009
9
Congenital mesoblastic nephroma rich from mitosis after in vitro fertilization: a case report. (18485932)
2008
10
WT1 expression and hemihypertrophy in congenital mesoblastic nephroma. (19011477)
2008
11
Congenital mesoblastic nephroma presenting with massive hematuria and hemorrhagic shock: report of one case. (17078466)
2006
12
Congenital mesoblastic nephroma presenting with neonatal hypertension. (15858607)
2005
13
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
14
Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. (14634980)
2003
15
Use of sarcoma-based chemotherapy in a case of congenital mesoblastic nephroma with liver metastases. (12809924)
2003
16
Multicystic congenital mesoblastic nephroma. (11927972)
2002
17
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)
2001
18
Cytogenetic and molecular characterization of a congenital mesoblastic nephroma. (11441343)
2001
19
Hyperreninemia and congenital mesoblastic nephroma: case report and review of the literature. (10792110)
2000
20
Congenital mesoblastic nephroma: A rare cause of perinatal anemia. (9931540)
1999
21
Congenital mesoblastic nephroma (CMN) with an unusual immunohistochemical feature. (10371751)
1999
22
Congenital mesoblastic nephroma: other magnetic resonance imaging findings. (10901975)
1999
23
Congenital mesoblastic nephroma. (9361489)
1997
24
Classical congenital mesoblastic nephroma in an adult: a case report on an Ethiopian. (10214440)
1997
25
Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. (9302166)
1997
26
A novel reciprocal translocation (14;15)(q11;q24) in a congenital mesoblastic nephroma. (8630977)
1996
27
Ultrastructure of cellular congenital mesoblastic nephroma. (8883325)
1996
28
The congenital mesoblastic nephroma: a case report of prenatal diagnosis. (8719724)
1996
29
Congenital mesoblastic nephroma associated with focal and segmental sclerosis. (8587629)
1995
30
Presence or absence of trisomy 11 is correlated with histologic subtype in congenital mesoblastic nephroma. (7923083)
1994
31
Congenital mesoblastic nephroma: an immunohistochemical and lectin study. (8387953)
1993
32
Congenital mesoblastic nephroma: cytogenetic comparison to leiomyoma. (8396768)
1993
33
Nucleolar organizer regions in congenital mesoblastic nephroma. (1333074)
1992
34
Preoperative chemotherapy of cellular congenital mesoblastic nephroma in a 5-month-old infant. (1281666)
1992
35
Congenital mesoblastic nephroma, hemorrhagic shock, and disseminated intravascular coagulation in a newborn infant. (1851423)
1991
36
Congenital mesoblastic nephroma occurring in a solitary kidney. (2157574)
1990
37
Congenital mesoblastic nephroma: report of a case. (2556493)
1989
38
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction. (2546131)
1989
39
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
40
Two chromosomally different cell populations in a partly cellular congenital mesoblastic nephroma. (3030229)
1987
41
Congenital mesoblastic nephroma study of 7 cases--report of a case of atypical mesoblastic nephroma. (2820867)
1986
42
Calcification and ossification in a congenital mesoblastic nephroma. (3000046)
1985
43
Cellular congenital mesoblastic nephroma in a newborn. (6097889)
1984
44
Prenatal sonographic detection of congenital mesoblastic nephroma in a monozygotic twin pregnancy. (6317883)
1983
45
Congenital mesoblastic nephroma presenting with primary reninism. (221639)
1979
46
Congenital mesoblastic nephroma. (189563)
1976
47
The management of benign renal tumors of infancy. Case report of a congenital mesoblastic nephroma (leiomyomatous hamartoma). (168170)
1975
48
Congenital mesoblastic nephroma of infancy. (164787)
1975
49
Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior. (4357122)
1973
50
Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms' tumor. (4378178)
1967

Variations for Congenital Mesoblastic Nephroma

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Expression for genes affiliated with Congenital Mesoblastic Nephroma

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Expression patterns in normal tissues for genes affiliated with Congenital Mesoblastic Nephroma

Search GEO for disease gene expression data for Congenital Mesoblastic Nephroma.

Pathways for genes affiliated with Congenital Mesoblastic Nephroma

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Pathways related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, SMARCB1
2
Show member pathways
9.4IGF2, REN, NTRK3
3
Show member pathways
8.7MDM2, NTRK3, VIM, IGF2
48.0WT1, MDM2, SSX2B, ETV6, KMT2A

Compounds for genes affiliated with Congenital Mesoblastic Nephroma

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Compounds related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1k252a449.8VIM, NTRK3
22-methoxyethanol449.8VIM, IGF2
3b 723449.8VIM, WT1
4p00001449.7KMT2A, MDM2
5prednisolone44 28 1111.7ETV6, KMT2A, IGF2
6n-(4-hydroxyphenyl)retinamide449.5IGF2, VIM
7chloramphenicol44 2 50 1112.4WT1, VIM, IGF2
8hydrocortisone44 2 61 1112.4IGF2, VIM, REN
9gefitinib44 50 1111.4MDM2, VIM, IGF2
10butyrate449.3WT1, VIM, IGF2
11valine449.3MDM2, VIM, IGF2
12vitamin d449.3IGF2, VIM, WT1
13indomethacin44 28 61 1112.3REN, VIM, IGF2
14calcitriol44 61 24 1112.2WT1, REN, KMT2A, IGF2
15paclitaxel44 50 1111.2MDM2, VIM, IGF2
16agar449.2IGF2, VIM, ETV6, MDM2
17imatinib44 50 1111.2IGF2, ETV6, NTRK3, MDM2, WT1
18rapamycin449.1IGF2, VIM, MDM2
19threonine449.1WT1, MDM2, NTRK3, KMT2A
20forskolin44 50 1111.1WT1, REN, VIM, IGF2
21roscovitine449.1VIM, MDM2
22glycogen44 2410.1MDM2, VIM, IGF2
23creatinine449.1IGF2, VIM, REN, WT1
24paraffin449.1IGF2, VIM, MDM2, WT1
25cycloheximide449.1IGF2, VIM, NTRK3, MDM2
26estradiol44 24 1111.0MDM2, REN, VIM, IGF2
27progesterone44 28 61 24 1113.0IGF2, VIM, MDM2, WT1
28steroid449.0IGF2, REN, MDM2, WT1, CTCF
29vincristine44 50 1111.0WT1, MDM2, VIM, KMT2A
30doxorubicin44 50 1110.9KMT2A, VIM, MDM2, WT1
31aspartate448.9KMT2A, VIM, NTRK3, MDM2
32dexamethasone44 50 28 1111.9IGF2, VIM, REN, MDM2
33actinomycin d448.9IGF2, KMT2A, VIM, MDM2
34genistein44 28 61 2 24 1113.9MDM2, VIM, KMT2A
35zinc44 249.9IGF2, KMT2A, MDM2, WT1, CTCF
36testosterone44 61 24 1111.8WT1, MDM2, NTRK3, VIM, IGF2
37proline448.7KMT2A, VIM, NTRK3, MDM2, WT1
385-aza-2deoxycytidine448.6IGF2, KMT2A, VIM, MDM2, CTCF
39etoposide44 50 61 1111.6IGF2, KMT2A, VIM, MDM2, WT1
40cysteine448.6WT1, MDM2, VIM, IGF2
41tyrosine448.6IGF2, KMT2A, ETV6, NTRK3, MDM2, WT1
42oligonucleotide448.6IGF2, KMT2A, VIM, MDM2, WT1
43estrogen448.5IGF2, KMT2A, VIM, MDM2, WT1
44retinoic acid44 249.5IGF2, KMT2A, VIM, ETV6, NTRK3, WT1
45serine448.2IGF2, KMT2A, VIM, MDM2, WT1, CTCF
46arginine448.2IGF2, KMT2A, VIM, REN, MDM2, WT1
47vegf448.1WT1, MDM2, NTRK3, REN, ETV6, VIM

GO Terms for genes affiliated with Congenital Mesoblastic Nephroma

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Cellular components related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.8CTCF, WT1, MDM2, SMARCB1
2nucleolusGO:0057307.7CTCF, SMARCB1, KMT2A, ETV6, MDM2, WT1

Biological processes related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of gene expression by genetic imprintingGO:0063499.8CTCF, IGF2
2positive regulation of gene expressionGO:0106289.5CTCF, MDM2, NTRK3
3negative regulation of cell proliferationGO:0082859.1WT1, KMT2A, SMARCB1
4regulation of transcription from RNA polymerase II promoterGO:0063579.0WT1, ETV6, SMARCB1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.6IGF2, SMARCB1, KMT2A, WT1

Molecular functions related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.7REN, IGF2
2p53 bindingGO:0020399.3MDM2, NTRK3, SMARCB1
3transcription regulatory region DNA bindingGO:0442129.2KMT2A, WT1, CTCF
4scaffold protein bindingGO:0971109.1MDM2, VIM
5sequence-specific DNA binding transcription factor activityGO:0037009.0CTCF, WT1, ETV6, KMT2A
6protein bindingGO:0055156.3IGF2, SMARCB1, KMT2A, VIM, ETV6, SSX2B

Products for genes affiliated with Congenital Mesoblastic Nephroma

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Sources for Congenital Mesoblastic Nephroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet