MCID: CNG029
MIFTS: 45

Congenital Mesoblastic Nephroma malady

Nephrological diseases category

Summaries for Congenital Mesoblastic Nephroma

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32MalaCards
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MalaCards: Congenital Mesoblastic Nephroma is related to mesoblastic nephroma and congenital fibrosarcoma. An important gene associated with Congenital Mesoblastic Nephroma is ETV6 (ets variant 6), and among its related pathways is Transcriptional misregulation in cancer. The compounds estrogen and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and bone, and related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Congenital Mesoblastic Nephroma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

congenital mesoblastic nephroma 8 42 10 48 60


External Ids:

Disease Ontology8 DOID:4773
NCIt39 C6569
MeSH34 D018201
ICD10 via Orphanet26 C64
SNOMED-CT via Orphanet57 11793003, 307604008
UMLS via Orphanet61 C1332965
MESH via Orphanet35 D018201

Related Diseases for Congenital Mesoblastic Nephroma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Adult Mesoblastic Nephroma family:

congenital mesoblastic nephroma Mesoblastic Nephroma

Diseases related to Congenital Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1mesoblastic nephroma30.7ETV6, IGF2, WT1
2congenital fibrosarcoma30.6ETV6
3fibrosarcoma30.6VIM, MDM2, NTRK3, ETV6
4sarcoma30.5VIM, WT1, MDM2, IGF2, ETV6, SMARCB1
5nephroblastoma30.4WT1
6clear cell sarcoma30.4WT1, IGF2
7beckwith-wiedemann syndrome30.3IGF2, CTCF, WT1
8cellular congenital mesoblastic nephroma10.9
9classic congenital mesoblastic nephroma10.6
10hypercalcemia10.6
11adult mesoblastic nephroma10.6
12polyhydramnios10.6
13hypertension10.6
14nephrocalcinosis10.4
15renal hypertension10.4
16cystic nephroma10.3
17kidney clear cell sarcoma10.3
18hypertrophic pyloric stenosis10.3
19disseminated intravascular coagulation10.3
20kidney sarcoma10.3
21leiomyoma10.3
22liver sarcoma10.3
23oligohydramnios10.3
24pediatric fibrosarcoma10.3
25pyloric stenosis10.3
26benign mesothelioma10.0WT1
27metanephric adenoma10.0WT1
28hyperandrogenism10.0IGF2
29wagr syndrome10.0WT1
30uterine sarcoma10.0MDM2
31liver cirrhosis10.0REN
32giant cell glioblastoma10.0MDM2
33atypical teratoid rhabdoid tumor10.0SMARCB1
34eosinophilia10.0ETV6
35sertoli-leydig cell tumor10.0WT1
36eye disease10.0MDM2
37rhabdoid cancer10.0SMARCB1
38oligodendroglioma10.0MDM2
39neurilemmoma10.0SMARCB1
40monocytic leukemia10.0KMT2A
41ataxia telangiectasia10.0MDM2
42hemihypertrophy10.0WT1, IGF2
43pancreatic cancer10.0NTRK3
44collecting duct carcinoma10.0SMARCB1
45primary hyperoxaluria10.0REN, WT1
46embryonal rhabdomyosarcoma10.0WT1, IGF2
47alveolar rhabdomyosarcoma10.0MDM2, WT1
48chordoma10.0VIM
49adenoma10.0REN, IGF2
50angiosarcoma10.0VIM

Graphical network of the top 20 diseases related to Congenital Mesoblastic Nephroma:



Diseases related to congenital mesoblastic nephroma

Clinical Features for Congenital Mesoblastic Nephroma

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Drugs & Therapeutics for Congenital Mesoblastic Nephroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Congenital Mesoblastic Nephroma

Drug clinical trials:

Search ClinicalTrials for Congenital Mesoblastic Nephroma

Search NIH Clinical Center for Congenital Mesoblastic Nephroma

Search CenterWatch for Congenital Mesoblastic Nephroma

Genetic Tests for Congenital Mesoblastic Nephroma

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Anatomical Context for Congenital Mesoblastic Nephroma

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32MalaCards
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MalaCards organs/tissues related to Congenital Mesoblastic Nephroma:

32
Kidney, Brain, Bone, Liver

Animal Models for Congenital Mesoblastic Nephroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Congenital Mesoblastic Nephroma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.7KMT2A, VIM
2MP:00053899.4WT1, REN, KMT2A
3MP:00036319.4KMT2A, NTRK3
4MP:00053698.7REN, IGF2, MDM2, WT1, VIM
5MP:00053708.6WT1, MDM2, IGF2, KMT2A, SMARCB1
6MP:00030128.5WT1, MDM2, NTRK3, IGF2, ETV6, KMT2A
7MP:00053678.5WT1, MDM2, IGF2, REN, KMT2A
8MP:00053977.5WT1, CTCF, MDM2, IGF2, ETV6, REN
9MP:00053857.5SMARCB1, VIM, WT1, MDM2, NTRK3, IGF2
10MP:00053787.4VIM, WT1, MDM2, NTRK3, IGF2, ETV6
11MP:00053847.3VIM, WT1, CTCF, MDM2, IGF2, ETV6
12MP:00053877.1VIM, WT1, CTCF, MDM2, IGF2, ETV6
13MP:00107686.8VIM, WT1, CTCF, MDM2, NTRK3, IGF2

Publications for Congenital Mesoblastic Nephroma

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50PubMed
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Articles related to Congenital Mesoblastic Nephroma:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Prenatal diagnosis of congenital mesoblastic nephroma. (22354312)
2013
2
Congenital mesoblastic nephroma: A rare cause of recurrent hematuria beyond infancy. (23960358)
2013
3
Cellular congenital mesoblastic nephroma: case report. (21541470)
2011
4
Pathology in practice. Congenital mesoblastic nephroma. (21961632)
2011
5
Regression of a congenital mesoblastic nephroma. (20582939)
2010
6
Congenital collision tumors, neonatal renal mesoblastic nephroma and pararenal paraganglioma. (19784003)
2009
7
Congenital mesoblastic nephroma rich from mitosis after in vitro fertilization: a case report. (18485932)
2008
8
A case of fetal congenital mesoblastic nephroma with oligohydramnios. (17449950)
2007
9
Atypical congenital mesoblastic nephroma presenting in the perinatal period. (17093992)
2007
10
Expression of ETV6-NTRK in classical, cellular and mixed subtypes of congenital mesoblastic nephroma. (16681692)
2006
11
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
12
Use of sarcoma-based chemotherapy in a case of congenital mesoblastic nephroma with liver metastases. (12809924)
2003
13
Multicystic congenital mesoblastic nephroma. (11927972)
2002
14
Hyperreninemia and congenital mesoblastic nephroma: case report and review of the literature. (10792110)
2000
15
Congenital mesoblastic nephroma: A rare cause of perinatal anemia. (9931540)
1999
16
Congenital mesoblastic nephroma and trisomy 11. (9595049)
1998
17
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. (9823307)
1998
18
Congenital mesoblastic nephroma. (9361489)
1997
19
Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. (9302166)
1997
20
A novel reciprocal translocation (14;15)(q11;q24) in a congenital mesoblastic nephroma. (8630977)
1996
21
Ultrastructure of cellular congenital mesoblastic nephroma. (8883325)
1996
22
The congenital mesoblastic nephroma: a case report of prenatal diagnosis. (8719724)
1996
23
Cytogenetic findings in a case of congenital mesoblastic nephroma. (8536223)
1995
24
Cytologic findings in congenital mesoblastic nephroma. A case report. (8147217)
1994
25
Congenital mesoblastic nephroma: cytogenetic comparison to leiomyoma. (8396768)
1993
26
Congenital mesoblastic nephroma metastatic to the brain. (8402467)
1993
27
Congenital mesoblastic nephroma in an adult: immunohistochemical study]. (8386502)
1993
28
Preoperative chemotherapy of cellular congenital mesoblastic nephroma in a 5-month-old infant. (1281666)
1992
29
Congenital cystic mesoblastic nephroma: a rare cystic renal tumour of childhood. Case report. (1332189)
1992
30
Molecular characterization of congenital mesoblastic nephroma and its distinction from Wilms tumor. (1327497)
1992
31
Pediatric case of the day. Congenital mesoblastic nephroma. (1653445)
1991
32
Congenital mesoblastic nephroma, nephrocalcinosis, and hypertrophic pyloric stenosis. (1656148)
1991
33
Adult variant of congenital mesoblastic nephroma. (2185715)
1990
34
Congenital mesoblastic nephroma, renin production, and hypertension. (2544716)
1989
35
Congenital mesoblastic nephroma in a dog: a benign variant of nephroblastoma. (2548317)
1989
36
Congenital mesoblastic nephroma: a clinicoradiologic study of 17 cases representing the pathologic spectrum of the disease. (3037055)
1987
37
An abdominal mass: the congenital mesoblastic nephroma (CMN). The pathologic basis of its management. (3033249)
1986
38
Cellular congenital mesoblastic nephroma in a newborn. (6097889)
1984
39
Congenital mesoblastic nephroma. (6293141)
1982
40
Congenital mesoblastic nephroma with cystic component. (6268664)
1981
41
Congenital cystic mesoblastic nephroma. (7319492)
1981
42
Congenital mesoblastic nephroma. (213965)
1978
43
Congenital mesoblastic nephroma and polyhydramnios. (210304)
1978
44
Congenital mesoblastic nephroma of infancy. (189732)
1976
45
The management of benign renal tumors of infancy. Case report of a congenital mesoblastic nephroma (leiomyomatous hamartoma). (168170)
1975
46
Letter: Congenital mesoblastic nephroma. (4370147)
1974
47
Letter: Congenital mesoblastic nephroma. (4359677)
1974
48
Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior. (4357122)
1973
49
Congenital mesoblastic nephroma (leiomyomatous hamartoma): first adult case. (4355052)
1973
50
Congenital mesoblastic nephroma of infancy. (4363286)
1973

Genetic Variations for Congenital Mesoblastic Nephroma

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Expression for genes affiliated with Congenital Mesoblastic Nephroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Mesoblastic Nephroma

Search GEO for disease gene expression data for Congenital Mesoblastic Nephroma.

Pathways for genes affiliated with Congenital Mesoblastic Nephroma

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29KEGG
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Pathways related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.5KMT2A, ETV6, SSX2B, MDM2, WT1

Compounds for genes affiliated with Congenital Mesoblastic Nephroma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1estrogen4410.2KMT2A
22-methoxyethanol4410.0IGF2, VIM
3k252a449.7VIM, NTRK3
4gefitinib44 49 1111.7IGF2, MDM2, VIM
5prednisolone44 28 1111.7IGF2, ETV6, KMT2A
6p00001449.6KMT2A, MDM2
7hydrocortisone44 2 59 1112.6REN, IGF2, VIM
8valine449.5IGF2, MDM2, VIM
9agar449.5ETV6, IGF2, MDM2, VIM
10b 723449.4WT1, VIM
11imatinib44 49 1111.4ETV6, IGF2, NTRK3, MDM2, WT1
12paraffin449.4VIM, WT1, MDM2, IGF2
13calcitriol44 59 11 2412.3KMT2A, REN, IGF2, WT1
14forskolin44 49 1111.3REN, IGF2, WT1, VIM
15estradiol44 11 2411.3REN, IGF2, MDM2, VIM
16chloramphenicol44 2 1111.3IGF2, WT1, VIM
17vincristine44 49 1111.2KMT2A, MDM2, WT1, VIM
18creatinine449.2VIM, WT1, IGF2, REN
19cycloheximide449.2VIM, MDM2, NTRK3, IGF2
20steroid449.2REN, MDM2, CTCF, WT1
21doxorubicin44 49 1111.2KMT2A, MDM2, WT1, VIM
22actinomycin d449.2VIM, MDM2, IGF2, KMT2A
23testosterone44 59 11 2412.1VIM, WT1, MDM2, NTRK3, IGF2
24progesterone44 59 28 11 2413.1VIM, WT1, MDM2, IGF2
25aspartate449.0KMT2A, NTRK3, MDM2, VIM
26proline449.0VIM, WT1, MDM2, NTRK3, KMT2A
27etoposide44 49 59 1111.9VIM, WT1, MDM2, IGF2, KMT2A
28oligonucleotide448.9VIM, WT1, MDM2, IGF2, KMT2A
29zinc44 249.7WT1, CTCF, MDM2, IGF2, KMT2A
30retinoic acid44 249.7VIM, WT1, NTRK3, IGF2, ETV6, KMT2A
31tyrosine448.7WT1, MDM2, NTRK3, IGF2, ETV6, KMT2A
325-aza-2deoxycytidine448.6VIM, CTCF, MDM2, IGF2, KMT2A
33arginine448.5VIM, WT1, MDM2, IGF2, REN, KMT2A
34vegf448.5VIM, WT1, MDM2, NTRK3, IGF2, ETV6
35serine448.2VIM, WT1, CTCF, MDM2, IGF2, KMT2A

GO Terms for genes affiliated with Congenital Mesoblastic Nephroma

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16Gene Ontology
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Biological processes related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of gene expression by genetic imprintingGO:0063499.5IGF2, CTCF
2positive regulation of gene expressionGO:0106288.9NTRK3, MDM2, CTCF

Molecular functions related to Congenital Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.7REN, IGF2
2scaffold protein bindingGO:0971109.7MDM2, VIM
3p53 bindingGO:0020399.5SMARCB1, NTRK3, MDM2
4transcription regulatory region DNA bindingGO:0442128.7KMT2A, CTCF, WT1
5protein bindingGO:0055155.9VIM, WT1, CTCF, MDM2, PRUNE, SSX2B

Products for genes affiliated with Congenital Mesoblastic Nephroma

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Sources for Congenital Mesoblastic Nephroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet