CRS
MCID: CNG124
MIFTS: 51

Congenital Rubella (CRS) malady

Fetal, Neuronal, Infectious categories

Summaries for Congenital Rubella

Sources:
3CDC, 64Wikipedia, 33MalaCards
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CDC:3 NIOSH Pocket Guide to Chemical Hazards Exposure limits, Respirator Recommendations, First Aid, more... The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards: Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and measles, and has symptoms including cataract/lens opacification, sensorineural deafness/hearing loss and speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia. An important gene associated with Congenital Rubella is UNG (uracil-DNA glycosylase), and among its related pathways is Regulation of thyroid hormone activity. The compounds selenium and hydrogen have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and heart, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Wikipedia:64 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Aliases & Classifications for Congenital Rubella

Sources:
61UMLS, 43NIH Rare Diseases, 49Orphanet, 39NCBI Bookshelf, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal, Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
congenital rubella syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

congenital rubella 43
congenital rubella syndrome 43 49 61
crs 43 39
rubella congenital 43
craniosynostosis 61


External Ids:

MESH via Orphanet36 D012410
ICD10 via Orphanet26 P35.0
SNOMED-CT via Orphanet58 1857005
UMLS via Orphanet62 C0035921
ICD1025 P35.0

Related Diseases for Congenital Rubella

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Congenital Rubella family:

rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1rubella32.0CD40LG
2measles30.9CD40LG
3thyroiditis30.3TPO, GAD2
4vasculitis30.0CD40LG
5acute myocardial infarction29.9CAT
6craniosynostosis, syndromic10.8
7n syndrome10.6
8craniosynostosis, nonsyndromic10.6
9fg syndrome10.5
10cataract, congenital10.4
11muenke syndrome10.4
12shprintzen-goldberg syndrome10.4
13baller-gerold syndrome10.4
14synostosis10.4
15west syndrome10.4
16saethre-chotzen syndrome10.3
17congenital cytomegalovirus10.3
18mass syndrome10.3
19cytomegalovirus infection10.3
20craniosynostosis autosomal dominant10.3
21crouzon syndrome10.3
22sleep apnea10.3
23craniosynostosis 510.3
24mumps10.2
25char syndrome10.2
26congenital mumps10.2
27craniosynostosis philadelphia type10.2
28plagiocephaly10.2
29fgfr-related craniosynostosis syndromes10.2
30genoa syndrome10.2
31mental retardation10.2
32craniosynostosis, type 210.2
33craniosynostosis 410.2
34syndactyly10.2
35acrocephalosyndactylia10.2
36jackson-weiss syndrome10.2
37hunter-mcalpine syndrome10.2
38fgfr3-related craniosynostosis10.2
39craniosynostosis and dental anomalies10.2
40congenital hypothyroidism10.2
41adult syndrome10.2
42hydranencephaly10.2
43microcephaly10.1
44craniosynostosis, anal anomalies, and porokeratosis10.1
45dandy-walker malformation with sagittal craniosynostosis and hydrocephalus10.1
46goldberg-shprintzen megacolon syndrome10.1
47herrmann opitz craniosynostosis10.1
48craniosynostosis, type 110.1
49craniosynostosis 310.1
50brachydactyly10.1

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to congenital rubella

Clinical Features for Congenital Rubella

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 32)
  • cataract/lens opacification
  • sensorineural deafness/hearing loss
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • intrauterine growth retardation
  • antenatal exposure : rubella
  • microcephaly
  • large fontanelle/delayed fontanelle closure
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • glaucoma
  • aniridia/iris hypoplasia
  • retinitis pigmentosa/retinal pigmentary changes
  • visual loss/blindness/amblyopia
  • strabismus/squint
  • nystagmus
  • cutaneous rash
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • pulmonary artery stenosis/absence/hypoplasia of the pulmonary branches
  • atrial septal defect/interauricular communication
  • ventricular septal defect/interventricular communication
  • patent ductus arteriosus
  • hypotonia
  • hypertonia/spasticity/rigidity/stiffness
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • anaemia
  • thrombocytopenia/thrombopenia
  • short stature/dwarfism/nanism
  • corneal clouding/opacity/vascularisation
  • hepatitis/icterus/cholestasis
  • insulin-dependent/type 1 diabetes
  • seizures/epilepsy/absences/spasms/status epilepticus
  • metaphyseal anomaly

Drugs & Therapeutics for Congenital Rubella

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Congenital Rubella

Drug clinical trials:

Search ClinicalTrials for Congenital Rubella

Search NIH Clinical Center for Congenital Rubella

Search CenterWatch for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Congenital Rubella:

33
Whole blood, Brain, Heart, Thyroid, Salivary gland, Skin, Placenta, T cells, Endothelial, Fetal brain, Fetal thyroid, Pancreatic islet

Animal Models for Congenital Rubella or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Congenital Rubella:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5CAT, UNG, GAD2, CD40LG, TPO
2MP:00053767.2CAT, UNG, GAD2, CD40LG, TPO

Publications for Congenital Rubella

Sources:
51PubMed
See all sources

Articles related to Congenital Rubella:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Spontaneously Regressing Leukoencephalopathy with Bilateral Temporal Cysts in Congenital Rubella Infection. (24153011)
2013
2
Rubella vaccine: new horizon in prevention of congenital rubella syndrome in the India. (22495120)
2012
3
Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination--United States, 2001-2010. (21592401)
2011
4
Elimination of rubella and congenital rubella syndrome in the Americas. (21954249)
2011
5
An update on cardiovascular malformations in congenital rubella syndrome. (19697432)
2010
6
Prevention of congenital rubella and congenital varicella in Europe. (19317971)
2009
7
Congenital rubella syndrome: pattern and presentation in a southern Nigerian tertiary hospital. (19911144)
2009
8
Congenital rubella: citation virus or viral cause of type 1 diabetes? (18641967)
2008
9
Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome. (17516526)
2007
10
Costs of congenital rubella syndrome (CRS) in Oman: evidence based on long-term follow-up of 43 children. (16814433)
2006
11
The evidence for the elimination of rubella and congenital rubella syndrome in the United States: a public health achievement. (16998770)
2006
12
Progress towards elimination of measles and prevention of congenital rubella infection in the WHO European Region, 1990-2004. (15771206)
2005
13
Congenital rubella infection following rubella outbreak in northern Italy, 2002: need for an effective vaccination programme. (15368099)
2004
14
Monitoring congenital rubella embryopathy. (15558544)
2004
15
An epidemiological and clinical study of ocular manifestations of congenital rubella syndrome in Omani children. (15078672)
2004
16
Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. (12824690)
2003
17
Accelerated rubella control and congenital rubella syndrome prevention strengthen measles eradication: the Costa Rican experience. (12721908)
2003
18
Susceptibility to rubella among pregnant women and the serological evidence of congenital rubella in newborn babies at Colombo South Teaching Hospital. (12971208)
2003
19
Congenital rubella syndrome in Haiti (Short communication). (12431359)
2002
20
Accelerated control of rubella and prevention of congenital rubella syndrome, Brazil. (12060965)
2002
21
Cases of congenital rubella may be the tip of the iceberg. (12228143)
2002
22
Preventing congenital rubella syndrome (CRS) through vaccination of susceptible women of childbearing age. (11571090)
2001
23
Congenital rubella syndrome: The need for standing orders for vaccination of susceptible women. (20084201)
2001
24
Incidence of congenital rubella in Greece has decreased. (10858064)
2000
25
Inconsistent immunisation policies increase incidence of congenital rubella syndrome (10582965)
1999
26
Rubella virus genome diagnosis during pregnancy and mechanism of congenital rubella. (10213891)
1998
27
Immunoglobulin G avidity in the serodiagnosis of congenital rubella syndrome. (9405951)
1997
28
Surveillance of congenital rubella syndrome and other rubella-associated adverse pregnancy outcomes. (8680371)
1996
29
Hydranencephaly/multicystic encephalomalacia: association with congenital rubella infection. (8375892)
1993
30
A lymphocyte transformation assay for the diagnosis of congenital rubella. (1597504)
1992
31
Congenital rubella in the Asian community in Britain. (2098023)
1990
32
Ventriculitis in congenital rubella: ultrasound demonstration. (3306592)
1987
33
Congenital rubella syndrome. (3762485)
1986
34
Congenital rubella--still with us. (3724611)
1986
35
Congenital rubella syndrome and physical growth: a 17-year, prospective, longitudinal follow-up in the Ryukyu Islands. (3797936)
1986
36
Congenital rubella syndrome in Western Australia. (4041177)
1985
37
Therapeutic abortions following rubella infection in pregnancy: the potential impact on the incidence of congenital rubella syndrome. (6496818)
1984
38
National Congenital Rubella Surveillance Programme 1971-81. (6812714)
1982
39
Congenital rubella following inapparent rubella infection. (7106886)
1982
40
Staphylococcal protein A in the serologic diagnosis of congenital rubella and toxoplasmosis. (6757889)
1982
41
Can we prevent an increase in the incidence of congenital rubella syndrome in the next decade? (7260807)
1981
42
Congenital rubella after maternal reinfection. (419373)
1979
43
Congenital rubella surveillance. (641854)
1978
44
Comparison of methods for detecting specific IgM antibody in infants with congenital rubella. (364063)
1978
45
Nuclear and cytoplasmic immunofluorescence in the cerebrospinal fluid cells from a neonate with congenital rubella. (347227)
1977
46
Congenital rubella syndrome: continuing challenge of a preventable infection. (837306)
1977
47
Progressive rubella panencephalitis. Late onset after congenital rubella. (1117960)
1975
48
Aqueductal occlusion in the congenital rubella syndrome. (4543944)
1974
49
Congenital rubella surveillance following epidemic rubella in a partially vaccinated community. (4834242)
1974
50
Histiocytic reaction in dysgammaglobulinemia and congenital rubella. (5465365)
1970

Genetic Variations for Congenital Rubella

Expression for genes affiliated with Congenital Rubella

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for genes affiliated with Congenital Rubella

Sources:
54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Congenital Rubella according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3TPO, GAD2

Compounds for genes affiliated with Congenital Rubella

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Congenital Rubella according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1selenium45 2411.2CAT
2hydrogen45 2411.1TPO
3deoxyribose45 2410.8UNG, CAT
4hypoxanthine45 11 2411.8UNG, CAT
5guaiacol45 2410.7TPO, CAT
6maltose45 1110.7GAD2, TPO
7125i459.6GAD2, TPO
8c-peptide459.5GAD2, TPO
9levodopa45 1110.5CAT, GAD2
10cytidine45 11 2411.5UNG, CD40LG
11uric acid45 2410.4CAT, TPO
12cardiolipin45 1110.3CD40LG, TPO
13dithiothreitol459.2CAT, TPO
14tetracycline45 1110.2TPO, CD40LG
15cycloheximide459.1CAT, UNG, TPO
16h2o2459.1TPO, CAT, UNG
17oligonucleotide458.9UNG, GAD2, TPO
18gliadin458.9TPO, CD40LG, GAD2
19mannitol45 119.8CAT, CD40LG
20ascorbic acid45 249.8TPO, CD40LG, CAT
21acetylcholine45 50 29 11 2412.8TPO, CD40LG, GAD2
22nitric oxide45 11 2410.8CAT, GAD2, TPO
23glutamate458.4GAD2, UNG, TPO, CD40LG
24cysteine458.3TPO, CD40LG, CAT, GAD2

GO Terms for genes affiliated with Congenital Rubella

Sources:
16Gene Ontology
See all sources

Biological processes related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hydrogen peroxide catabolic processGO:0427449.3TPO, CAT

Products for genes affiliated with Congenital Rubella

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Rubella

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet