CRS
MCID: CNG124
MIFTS: 44

Congenital Rubella (CRS) malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Congenital Rubella

Aliases & Descriptions for Congenital Rubella:

Name: Congenital Rubella 50
Congenital Rubella Syndrome 50 56 69
Crs 50 56 45
Fetal Rubella Syndrome 56
Rubella Congenital 50

Characteristics:

Orphanet epidemiological data:

56
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



External Ids:

Orphanet 56 ORPHA290
MESH via Orphanet 43 D012410
UMLS via Orphanet 70 C0035921
ICD10 via Orphanet 34 P35.0
ICD10 33 P35.0

Summaries for Congenital Rubella

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and measles, and has symptoms including seizures, nystagmus and intellectual disability. An important gene associated with Congenital Rubella is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Allograft rejection and Primary immunodeficiency. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and t cells, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 71 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 rubella 11.5
2 measles 10.2
3 hyperparathyroidism, primary, caused by water clear cell hyperplasia 10.1 CD40LG UNG
4 hypoparathyroidism, x-linked 10.1 CD40LG UNG
5 cataract 10.1
6 abdominal tuberculosis 10.0 CALR CD40LG
7 temtamy syndrome 10.0 CD40LG UNG
8 type 2 papillary adenoma of the kidney 10.0 CD40LG UNG
9 chromosome 17q23.1-q23.2 deletion syndrome 9.9 CALR CAT
10 articulation disorder 9.9 CD40LG TPO
11 drug psychosis 9.9 CAT CD40LG
12 pseudohypoparathyroidism 9.9 CAT CD40LG
13 cytomegalovirus infection 9.9
14 parasitic helminthiasis infectious disease 9.8 CALR CD40LG TPO
15 testicular lymphoma 9.8 CD40LG TPO
16 inflammatory bowel disease 3 9.8 CALR CD40LG TPO
17 encephalitis 9.8
18 thyroiditis 9.8
19 mumps 9.8
20 nail disorder, nonsyndromic congenital, 7 9.8 CAT TPO
21 hypothyroidism 9.7
22 pulmonary hypertension 9.7
23 hydranencephaly 9.7
24 pneumonia 9.7
25 keratoconus 9.7
26 corneal edema 9.6
27 duodenitis 9.6
28 heart disease 9.6
29 vasculitis 9.6
30 myxedema 9.6
31 dysgammaglobulinemia 9.6
32 hashimoto thyroiditis 9.6
33 esophagitis 9.6
34 toxoplasmosis 9.6
35 wolff-parkinson-white syndrome 9.6
36 uveitis 9.6
37 central serous chorioretinopathy 9.6
38 cryptorchidism 9.6
39 patent ductus arteriosus 9.6
40 growth hormone deficiency 9.6
41 jejunal atresia 9.6
42 tracheoesophageal fistula 9.6
43 encephalomalacia 9.6
44 aneurysm 9.6
45 autistic disorder 9.6
46 pancreatitis 9.6
47 encephalopathy 9.6
48 hemolytic anemia 9.6
49 endotheliitis 9.6
50 viral esophagitis 9.6

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

56 32 (show all 32)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 56 32 Occasional (29-5%) HP:0001250
2 nystagmus 56 32 Frequent (79-30%) HP:0000639
3 intellectual disability 56 32 Frequent (79-30%) HP:0001249
4 muscular hypotonia 56 32 Frequent (79-30%) HP:0001252
5 neurological speech impairment 56 32 Very frequent (99-80%) HP:0002167
6 cataract 56 32 Very frequent (99-80%) HP:0000518
7 splenomegaly 56 32 Frequent (79-30%) HP:0001744
8 hepatomegaly 56 32 Frequent (79-30%) HP:0002240
9 corneal opacity 56 32 Occasional (29-5%) HP:0007957
10 microcephaly 56 32 Frequent (79-30%) HP:0000252
11 sensorineural hearing impairment 56 32 Very frequent (99-80%) HP:0000407
12 visual impairment 56 32 Frequent (79-30%) HP:0000505
13 short stature 56 32 Frequent (79-30%) HP:0004322
14 abnormality of retinal pigmentation 56 32 Frequent (79-30%) HP:0007703
15 type i diabetes mellitus 56 32 Occasional (29-5%) HP:0100651
16 anemia 56 32 Frequent (79-30%) HP:0001903
17 abnormality of the metaphyses 56 32 Occasional (29-5%) HP:0000944
18 strabismus 56 32 Frequent (79-30%) HP:0000486
19 patent ductus arteriosus 56 32 Frequent (79-30%) HP:0001643
20 thrombocytopenia 56 32 Frequent (79-30%) HP:0001873
21 jaundice 56 32 Occasional (29-5%) HP:0000952
22 microphthalmia 56 32 Frequent (79-30%) HP:0000568
23 intrauterine growth retardation 56 32 Very frequent (99-80%) HP:0001511
24 glaucoma 56 32 Frequent (79-30%) HP:0000501
25 abnormality of the fontanelles or cranial sutures 56 32 Frequent (79-30%) HP:0000235
26 ventricular septal defect 56 32 Frequent (79-30%) HP:0001629
27 skin rash 56 32 Frequent (79-30%) HP:0000988
28 aplasia/hypoplasia of the iris 56 32 Frequent (79-30%) HP:0008053
29 abnormality of the pulmonary artery 56 32 Frequent (79-30%) HP:0004414
30 spastic diplegia 56 32 Frequent (79-30%) HP:0001264
31 atria septal defect 56 Frequent (79-30%)
32 atrial septal defect 32 HP:0001631

MGI Mouse Phenotypes related to Congenital Rubella:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 CALR CAT CD40LG TPO UNG
2 mortality/aging MP:0010768 9.02 CALR CAT CD40LG TPO UNG

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of Age Not yet recruiting NCT03071575 Phase 4
2 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808
3 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Recruiting NCT02787486

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

39
Skin, Thyroid, T Cells, Eye, Testes, Brain, Endothelial

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 554)
id Title Authors Year
1
Hospital-based surveillance of congenital rubella syndrome in Indonesia. ( 28091778 )
2017
2
The end of measles and congenital rubella: an achievable dream? ( 28067934 )
2017
3
Congenital Rubella. ( 27732820 )
2016
4
Using the two-source capture-recapture method to estimate the incidence and case ascertainment of congenital rubella syndrome in Australia, 1993-2013. ( 27757254 )
2016
5
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy. ( 27866768 )
2016
6
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. ( 27757248 )
2016
7
Vaccination in secondary school students expedites rubella control and prevents congenital rubella syndrome. ( 27899091 )
2016
8
Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. ( 27244797 )
2016
9
Localization of Viral Antigens Improves Understanding of Congenital Rubella Syndrome Pathophysiology. ( 26870811 )
2016
10
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. ( 27606025 )
2016
11
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? ( 27343317 )
2016
12
A case of congenital rubella syndrome and infection in South-East London in 2015: prevention, diagnosis, and the public health response. ( 27884915 )
2016
13
Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. ( 27002428 )
2016
14
Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review. ( 26962867 )
2016
15
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania. ( 27225802 )
2016
16
Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome. ( 26870820 )
2016
17
Congenital rubella syndrome with death from interstitial pneumonia. ( 26840886 )
2016
18
Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome. ( 26350479 )
2015
19
An epidemiological assessment towards elimination of rubella and congenital rubella syndrome in Singapore. ( 25887085 )
2015
20
Congenital rubella syndrome (CRS) in Vietnam 2011-2012--CRS epidemic after rubella epidemic in 2010-2011. ( 26087296 )
2015
21
[Epidemiologic Surveillance on Measles, Rubella and Congenital Rubella Syndrome. Spain]. ( 26580792 )
2015
22
Further efforts in the achievement of congenital rubella syndrome/rubella elimination. ( 25483539 )
2015
23
Epidemiological characteristics of rubella and congenital rubella syndrome in the 2012-2013 epidemics in Tokyo, Japan. ( 25672351 )
2015
24
Congenital rubella syndrome: Global issue. ( 26049858 )
2015
25
Violaceous Maculopapular Rash in a Newborn: Congenital Rubella Syndrome. ( 26538723 )
2015
26
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2014. ( 26410894 )
2015
27
Congenital rubella still a public health problem in Italy: analysis of national surveillance data from 2005 to 2013. ( 25953272 )
2015
28
Congenital rubella syndrome: a matter of concern. ( 25988255 )
2015
29
Successful elimination of rubella and congenital rubella syndrome from the American region: A historical breakthrough. ( 26664432 )
2015
30
Intracranial epidural hematoma in a newborn with DIC secondary to congenital rubella. ( 26834916 )
2015
31
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989. ( 26469722 )
2015
32
Shedding of Rubella Virus in Congenital Rubella Syndrome: Study of Affected Infants Born in Tokyo, Japan, 2013-2014. ( 26567831 )
2015
33
50 Years Ago in The Journal of Pediatrics: Congenital Rubella Syndrome: New Clinical Aspects with Recovery of Virus from Affected Infants. ( 26210840 )
2015
34
Surveillance of congenital rubella and rubella infections in pregnancy in EU/EEA countries, 2012: Current status and future perspective to monitor elimination. ( 26209837 )
2015
35
Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis. ( 26137534 )
2015
36
Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. ( 25785205 )
2015
37
Prevalence of glaucoma and cataract morphology in congenital rubella syndrome. ( 25840326 )
2015
38
Global Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination - 2000-2014. ( 26401958 )
2015
39
Dental manifestations of congenital rubella syndrome. ( 25721843 )
2015
40
Identification of ocular and auditory manifestations of congenital rubella syndrome in mbingo. ( 25525427 )
2014
41
Successful detection and genotyping of rubella virus from preserved umbilical cord of patients with congenital rubella syndrome. ( 25378458 )
2014
42
Surveillance for congenital rubella in Australia since 1993: cases reported between 2004 and 2013. ( 25454858 )
2014
43
Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability-Adjusted Life Years (DALYs). ( 25115193 )
2014
44
Wolff-Parkinson-White Syndrome in Congenital Rubella Syndrome. ( 24567174 )
2014
45
Short-term Prediction of the Incidence of Congenital Rubella Syndrome. ( 25642379 )
2014
46
Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis. ( 25654000 )
2014
47
Identification of congenital rubella syndrome in Sudan. ( 24898017 )
2014
48
Congenital rubella syndrome in child of woman without known risk factors, New Jersey, USA. ( 24447409 )
2014
49
Further efforts in the achievement of congenital rubella syndrome/rubella elimination: alternative sources of information for retrospective case-finding, Puglia region, Italy, 2003-2011. ( 25184620 )
2014
50
Congenital rubella syndrome and immunity status of immigrant women living in southern Italy: a cross-sectional, seroepidemiological investigation. ( 24502919 )
2014

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.87 CALR CD40LG TPO
2 10.19 CD40LG UNG

GO Terms for Congenital Rubella

Cellular components related to Congenital Rubella according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 CALR CD40LG TPO
2 extracellular space GO:0005615 8.92 CALR CAT CD40LG TPO

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.37 CAT CD40LG
2 response to oxidative stress GO:0006979 9.32 CAT TPO
3 response to estradiol GO:0032355 9.26 CALR CAT
4 cellular oxidant detoxification GO:0098869 9.16 CAT TPO
5 negative regulation of apoptotic process GO:0043066 9.13 CAT CD40LG UNG
6 hydrogen peroxide catabolic process GO:0042744 8.62 CAT TPO

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 CAT TPO
2 peroxidase activity GO:0004601 8.62 CAT TPO

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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