MCID: CNG124
MIFTS: 43

Congenital Rubella

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Congenital Rubella

MalaCards integrated aliases for Congenital Rubella:

Name: Congenital Rubella 50
Congenital Rubella Syndrome 50 56 69
Crs 50 56 45
Fetal Rubella Syndrome 56
Rubella Congenital 50

Characteristics:

Orphanet epidemiological data:

56
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



Summaries for Congenital Rubella

NIH Rare Diseases : 50 congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes german measles (rubella) during pregnancy. congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. after the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby. the most common problems are hearing loss due to damage to the nerve pathways from the inner ear to the brain (sensorineural hearing loss), ocular abnormalities (cataract, infantile glaucoma, and pigmentary retinopathy) and heart problems. other symptoms and signs may include intrauterine growth retardation, prematurity, stillbirth, miscarriage, neurological problems (intellectual disability, low muscle tone, very small head), liver and spleen enlargement (hepatosplenomegaly), jaundice, skin problems, anemia, hormonal problems, and other issues.  the number of babies born with congenital rubella is much less since the rubella vaccine was developed. pregnant women who are not vaccinated for rubella and who have not had the disease in the past risk infecting themselves and their unborn baby. please visit the link from the centers for diseases control and prevention (cdc) to learn more about rubella vaccination: rubella (german measles) vaccination last updated: 9/15/2017

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and measles, and has symptoms including abnormality of the fontanelles or cranial sutures, microcephaly and sensorineural hearing impairment. An important gene associated with Congenital Rubella is CAT (Catalase), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and Adenosine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart.

Wikipedia : 72 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 rubella 11.5
2 measles 10.2
3 cataract 10.1
4 moved to 614436 10.0 CD40LG UNG
5 periarthritis 9.9 CD40LG UNG
6 hypoparathyroidism, x-linked 9.9 CD40LG UNG
7 drug psychosis 9.9 CAT CD40LG
8 cytomegalovirus infection 9.9
9 lateral cystocele 9.9 CAT CD40LG
10 ehlers-danlos syndrome, periodontal type, 1 9.8 CD40LG UNG
11 mumps 9.8
12 thyroiditis 9.8
13 encephalitis 9.8
14 pulmonary hypertension 9.7
15 keratoconus 9.7
16 hypothyroidism 9.7
17 hydranencephaly 9.7
18 pneumonia 9.7
19 hashimoto thyroiditis 9.6
20 wolff-parkinson-white syndrome 9.6
21 cryptorchidism 9.6
22 jejunal atresia 9.6
23 autistic disorder 9.6
24 hemolytic anemia 9.6
25 hepatitis 9.6
26 keratopathy 9.6
27 autism spectrum disorder 9.6
28 corneal edema 9.6
29 heart disease 9.6
30 myxedema 9.6
31 dysgammaglobulinemia 9.6
32 esophagitis 9.6
33 uveitis 9.6
34 patent ductus arteriosus 9.6
35 encephalomalacia 9.6
36 cerebritis 9.6
37 pancreatitis 9.6
38 viral esophagitis 9.6
39 hyperthyroidism 9.6
40 duodenitis 9.6
41 vasculitis 9.6
42 toxoplasmosis 9.6
43 central serous chorioretinopathy 9.6
44 growth hormone deficiency 9.6
45 tracheoesophageal fistula 9.6
46 aneurysm 9.6
47 encephalopathy 9.6
48 endotheliitis 9.6
49 rubella panencephalitis 9.6
50 autoinflammation with arthritis and dyskeratosis 9.6 CAT TPO

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

56 32 (show all 33)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the fontanelles or cranial sutures 56 32 frequent (33%) Frequent (79-30%) HP:0000235
2 microcephaly 56 32 frequent (33%) Frequent (79-30%) HP:0000252
3 sensorineural hearing impairment 56 32 hallmark (90%) Very frequent (99-80%) HP:0000407
4 strabismus 56 32 frequent (33%) Frequent (79-30%) HP:0000486
5 glaucoma 56 32 frequent (33%) Frequent (79-30%) HP:0000501
6 visual impairment 56 32 frequent (33%) Frequent (79-30%) HP:0000505
7 cataract 56 32 hallmark (90%) Very frequent (99-80%) HP:0000518
8 microphthalmia 56 32 frequent (33%) Frequent (79-30%) HP:0000568
9 nystagmus 56 32 frequent (33%) Frequent (79-30%) HP:0000639
10 jaundice 56 32 occasional (7.5%) Occasional (29-5%) HP:0000952
11 skin rash 56 32 frequent (33%) Frequent (79-30%) HP:0000988
12 intellectual disability 56 32 frequent (33%) Frequent (79-30%) HP:0001249
13 seizures 56 32 occasional (7.5%) Occasional (29-5%) HP:0001250
14 muscular hypotonia 56 32 frequent (33%) Frequent (79-30%) HP:0001252
15 spastic diplegia 56 32 frequent (33%) Frequent (79-30%) HP:0001264
16 intrauterine growth retardation 56 32 hallmark (90%) Very frequent (99-80%) HP:0001511
17 ventricular septal defect 56 32 frequent (33%) Frequent (79-30%) HP:0001629
18 patent ductus arteriosus 56 32 frequent (33%) Frequent (79-30%) HP:0001643
19 splenomegaly 56 32 frequent (33%) Frequent (79-30%) HP:0001744
20 thrombocytopenia 56 32 frequent (33%) Frequent (79-30%) HP:0001873
21 anemia 56 32 frequent (33%) Frequent (79-30%) HP:0001903
22 neurological speech impairment 56 32 hallmark (90%) Very frequent (99-80%) HP:0002167
23 hepatomegaly 56 32 frequent (33%) Frequent (79-30%) HP:0002240
24 short stature 56 32 frequent (33%) Frequent (79-30%) HP:0004322
25 abnormality of the pulmonary artery 56 32 frequent (33%) Frequent (79-30%) HP:0004414
26 abnormality of retinal pigmentation 56 32 frequent (33%) Frequent (79-30%) HP:0007703
27 corneal opacity 56 32 occasional (7.5%) Occasional (29-5%) HP:0007957
28 aplasia/hypoplasia of the iris 56 32 frequent (33%) Frequent (79-30%) HP:0008053
29 type i diabetes mellitus 56 32 occasional (7.5%) Occasional (29-5%) HP:0100651
30 abnormality of the metaphyses 56 Occasional (29-5%)
31 atria septal defect 56 Frequent (79-30%)
32 abnormality of the metaphysis 32 occasional (7.5%) HP:0000944
33 atrial septal defect 32 frequent (33%) HP:0001631

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2
Adenosine Approved, Investigational 58-61-7 60961

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of Age Not yet recruiting NCT03071575 Phase 4
2 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

39
Skin, Brain, Heart, Spleen, Liver, Thyroid, Eye

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 562)
id Title Authors Year
1
An update on epidemiology of congenital rubella syndrome: how far from the World Health Organization goals? ( 28728344 )
2017
2
50 Years Ago in The Journal of Pediatrics: Cerebral Lesions in Congenital Rubella Syndrome. ( 28129869 )
2017
3
The end of measles and congenital rubella: an achievable dream? ( 28067934 )
2017
4
Two Imported Cases of Congenital Rubella Syndrome and Infection-Control Challenges in New York State, 2013-2015. ( 28510706 )
2017
5
Hospital-based surveillance of congenital rubella syndrome in Indonesia. ( 28091778 )
2017
6
Sensory defects and developmental delay among children with congenital rubella syndrome. ( 28406248 )
2017
7
Underreporting of congenital rubella in Italy, 2010-2014. ( 28551878 )
2017
8
Congenital rubella syndrome: an unusual cause of neonatal fulminant hepatic failure. ( 28678001 )
2017
9
Clinically Confirmed Congenital Rubella Syndrome: The Role of Echocardiography. ( 28579716 )
2017
10
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? ( 27343317 )
2016
11
Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. ( 27002428 )
2016
12
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy. ( 27866768 )
2016
13
Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome. ( 26870820 )
2016
14
Vaccination in secondary school students expedites rubella control and prevents congenital rubella syndrome. ( 27899091 )
2016
15
Congenital rubella syndrome with death from interstitial pneumonia. ( 26840886 )
2016
16
Congenital Rubella. ( 27732820 )
2016
17
Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review. ( 26962867 )
2016
18
A case of congenital rubella syndrome and infection in South-East London in 2015: prevention, diagnosis, and the public health response. ( 27884915 )
2016
19
Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. ( 27244797 )
2016
20
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania. ( 27225802 )
2016
21
Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review. ( 28115948 )
2016
22
Localization of Viral Antigens Improves Understanding of Congenital Rubella Syndrome Pathophysiology. ( 26870811 )
2016
23
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. ( 27757248 )
2016
24
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. ( 27606025 )
2016
25
Using the two-source capture-recapture method to estimate the incidence and case ascertainment of congenital rubella syndrome in Australia, 1993-2013. ( 27757254 )
2016
26
Prevalence of glaucoma and cataract morphology in congenital rubella syndrome. ( 25840326 )
2015
27
Violaceous Maculopapular Rash in a Newborn: Congenital Rubella Syndrome. ( 26538723 )
2015
28
Shedding of Rubella Virus in Congenital Rubella Syndrome: Study of Affected Infants Born in Tokyo, Japan, 2013-2014. ( 26567831 )
2015
29
Dental manifestations of congenital rubella syndrome. ( 25721843 )
2015
30
An epidemiological assessment towards elimination of rubella and congenital rubella syndrome in Singapore. ( 25887085 )
2015
31
Epidemiological characteristics of rubella and congenital rubella syndrome in the 2012-2013 epidemics in Tokyo, Japan. ( 25672351 )
2015
32
Congenital rubella syndrome: Global issue. ( 26049858 )
2015
33
Surveillance of congenital rubella and rubella infections in pregnancy in EU/EEA countries, 2012: Current status and future perspective to monitor elimination. ( 26209837 )
2015
34
Congenital rubella syndrome (CRS) in Vietnam 2011-2012--CRS epidemic after rubella epidemic in 2010-2011. ( 26087296 )
2015
35
Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. ( 25785205 )
2015
36
Intracranial epidural hematoma in a newborn with DIC secondary to congenital rubella. ( 26834916 )
2015
37
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989. ( 26469722 )
2015
38
Further efforts in the achievement of congenital rubella syndrome/rubella elimination. ( 25483539 )
2015
39
Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis. ( 26137534 )
2015
40
[Epidemiologic Surveillance on Measles, Rubella and Congenital Rubella Syndrome. Spain]. ( 26580792 )
2015
41
Congenital rubella syndrome: a matter of concern. ( 25988255 )
2015
42
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2014. ( 26410894 )
2015
43
Successful elimination of rubella and congenital rubella syndrome from the American region: A historical breakthrough. ( 26664432 )
2015
44
Global Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination - 2000-2014. ( 26401958 )
2015
45
Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome. ( 26350479 )
2015
46
50 Years Ago in The Journal of Pediatrics: Congenital Rubella Syndrome: New Clinical Aspects with Recovery of Virus from Affected Infants. ( 26210840 )
2015
47
Congenital rubella still a public health problem in Italy: analysis of national surveillance data from 2005 to 2013. ( 25953272 )
2015
48
Surveillance of congenital rubella syndrome (CRS) in tertiary care hospitals in Hanoi, Vietnam during a rubella epidemic. ( 25444828 )
2014
49
Successful detection and genotyping of rubella virus from preserved umbilical cord of patients with congenital rubella syndrome. ( 25378458 )
2014
50
Identification of congenital rubella syndrome in Sudan. ( 24898017 )
2014

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG UNG

GO Terms for Congenital Rubella

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 CAT CD40LG
2 response to oxidative stress GO:0006979 9.26 CAT TPO
3 cellular oxidant detoxification GO:0098869 9.16 CAT TPO
4 negative regulation of apoptotic process GO:0043066 9.13 CAT CD40LG UNG
5 hydrogen peroxide catabolic process GO:0042744 8.62 CAT TPO

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 CAT TPO
2 peroxidase activity GO:0004601 8.62 CAT TPO

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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