MCID: CNG124
MIFTS: 47

Congenital Rubella

Categories: Rare diseases, Fetal diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Congenital Rubella

MalaCards integrated aliases for Congenital Rubella:

Name: Congenital Rubella 49
Congenital Rubella Syndrome 49 55 69
Crs 49 55 44
Fetal Rubella Syndrome 55
Rubella Congenital 49

Characteristics:

Orphanet epidemiological data:

55
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



Summaries for Congenital Rubella

NIH Rare Diseases : 49 Congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes German measles (rubella) during pregnancy. Congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. After the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby. The most common problems are hearing loss due to damage to the nerve pathways from the inner ear to the brain (sensorineural hearing loss), ocular abnormalities (cataract, infantile glaucoma, and pigmentary retinopathy) and heart problems. Other symptoms and signs may include intrauterine growth retardation, prematurity, stillbirth, miscarriage, neurological problems (intellectual disability, low muscle tone, very small head), liver and spleen enlargement (hepatosplenomegaly), jaundice, skin problems, anemia, hormonal problems, and other issues.  The number of babies born with congenital rubella is much less since the rubella vaccine was developed. Pregnant women who are not vaccinated for rubella and who have not had the disease in the past risk infecting themselves and their unborn baby. Please visit the link from the Centers for Diseases Control and Prevention (CDC) to learn more about rubella vaccination: Rubella (German Measles) Vaccination Last updated: 9/15/2017

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to immunodeficiency with hyper-igm, type 1 and rubella, and has symptoms including abnormality of the fontanelles or cranial sutures, microcephaly and sensorineural hearing impairment. An important gene associated with Congenital Rubella is CAT (Catalase), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and Adenosine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart.

Wikipedia : 72 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency with hyper-igm, type 1 29.3 CD40LG UNG
2 rubella 11.6
3 measles 10.3
4 aging 10.2
5 cataract 10.1
6 diabetes mellitus 10.1
7 branchiootic syndrome 1 10.0
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
9 cytomegalovirus infection 10.0
10 immunodeficiency with hyper-igm, type 4 9.9 CD40LG UNG
11 hyperimmunoglobulin syndrome 9.9 CD40LG UNG
12 autism 9.9
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
14 mumps 9.9
15 thyroiditis 9.9
16 encephalitis 9.9
17 cryptosporidiosis 9.9 CAT CD40LG
18 syphilis 9.9 CAT CD40LG
19 immunodeficiency with hyper-igm, type 2 9.8 CD40LG UNG
20 light fixation seizure syndrome 9.8
21 pulmonary hypertension 9.8
22 keratoconus 9.8
23 hypothyroidism 9.8
24 hydranencephaly 9.8
25 pneumonia 9.8
26 multinodular goiter 9.7 CAT TPO
27 hashimoto thyroiditis 9.7
28 wolff-parkinson-white syndrome 9.7
29 cryptorchidism, unilateral or bilateral 9.7
30 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.7
31 jejunal atresia 9.7
32 myxedema 9.7
33 interstitial pneumonitis, desquamative, familial 9.7
34 graves disease 1 9.7
35 patent ductus arteriosus 1 9.7
36 hydrops, lactic acidosis, and sideroblastic anemia 9.7
37 hemolytic anemia 9.7
38 hepatitis 9.7
39 keratopathy 9.7
40 desquamative interstitial pneumonia 9.7
41 autism spectrum disorder 9.7
42 corneal edema 9.7
43 heart disease 9.7
44 dysgammaglobulinemia 9.7
45 esophagitis 9.7
46 uveitis 9.7
47 encephalomalacia 9.7
48 cerebritis 9.7
49 pancreatitis 9.7
50 viral esophagitis 9.7

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

55 31 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the fontanelles or cranial sutures 55 31 frequent (33%) Frequent (79-30%) HP:0000235
2 microcephaly 55 31 frequent (33%) Frequent (79-30%) HP:0000252
3 sensorineural hearing impairment 55 31 hallmark (90%) Very frequent (99-80%) HP:0000407
4 strabismus 55 31 frequent (33%) Frequent (79-30%) HP:0000486
5 glaucoma 55 31 frequent (33%) Frequent (79-30%) HP:0000501
6 visual impairment 55 31 frequent (33%) Frequent (79-30%) HP:0000505
7 cataract 55 31 hallmark (90%) Very frequent (99-80%) HP:0000518
8 microphthalmia 55 31 frequent (33%) Frequent (79-30%) HP:0000568
9 nystagmus 55 31 frequent (33%) Frequent (79-30%) HP:0000639
10 abnormality of the metaphysis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000944
11 jaundice 55 31 occasional (7.5%) Occasional (29-5%) HP:0000952
12 skin rash 55 31 frequent (33%) Frequent (79-30%) HP:0000988
13 intellectual disability 55 31 frequent (33%) Frequent (79-30%) HP:0001249
14 seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0001250
15 muscular hypotonia 55 31 frequent (33%) Frequent (79-30%) HP:0001252
16 spastic diplegia 55 31 frequent (33%) Frequent (79-30%) HP:0001264
17 intrauterine growth retardation 55 31 hallmark (90%) Very frequent (99-80%) HP:0001511
18 ventricular septal defect 55 31 frequent (33%) Frequent (79-30%) HP:0001629
19 atrial septal defect 55 31 frequent (33%) Frequent (79-30%) HP:0001631
20 patent ductus arteriosus 55 31 frequent (33%) Frequent (79-30%) HP:0001643
21 splenomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0001744
22 thrombocytopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001873
23 anemia 55 31 frequent (33%) Frequent (79-30%) HP:0001903
24 neurological speech impairment 55 31 hallmark (90%) Very frequent (99-80%) HP:0002167
25 hepatomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0002240
26 short stature 55 31 frequent (33%) Frequent (79-30%) HP:0004322
27 abnormality of the pulmonary artery 55 31 frequent (33%) Frequent (79-30%) HP:0004414
28 abnormality of retinal pigmentation 55 31 frequent (33%) Frequent (79-30%) HP:0007703
29 corneal opacity 55 31 occasional (7.5%) Occasional (29-5%) HP:0007957
30 aplasia/hypoplasia of the iris 55 31 frequent (33%) Frequent (79-30%) HP:0008053
31 type i diabetes mellitus 55 31 occasional (7.5%) Occasional (29-5%) HP:0100651

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2
Adenosine Approved, Investigational 58-61-7 60961

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of Age Not yet recruiting NCT03071575 Phase 4
2 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

38
Skin, Brain, Heart, Spleen, Liver, Thyroid, Eye

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 568)
# Title Authors Year
1
An infant with congenital rubella syndrome in developing India. ( 29184005 )
2017
2
Clinical profile of congenital rubella syndrome in Yogyakarta, Indonesia. ( 29068106 )
2017
3
Underreporting of congenital rubella in Italy, 2010-2014. ( 28551878 )
2017
4
Two Imported Cases of Congenital Rubella Syndrome and Infection-Control Challenges in New York State, 2013-2015. ( 28510706 )
2017
5
Progress in rubella and congenital rubella syndrome control and elimination a89 worldwide, 2000a892016. ( 29148274 )
2017
6
Lacrimal drainage anomalies in congenital rubella syndrome. ( 29184387 )
2017
7
Progress in Rubella and Congenital Rubella Syndrome Control and Elimination - Worldwide, 2000-2016. ( 29145358 )
2017
8
50 Years Ago in The Journal of Pediatrics: Cerebral Lesions in Congenital Rubella Syndrome. ( 28129869 )
2017
9
The end of measles and congenital rubella: an achievable dream? ( 28067934 )
2017
10
Congenital rubella syndrome: an unusual cause of neonatal fulminant hepatic failure. ( 28678001 )
2017
11
The burden of congenital rubella syndrome in the Philippines: results from a retrospective assessment. ( 29184700 )
2017
12
Clinically Confirmed Congenital Rubella Syndrome: The Role of Echocardiography. ( 28579716 )
2017
13
Hospital-based surveillance of congenital rubella syndrome in Indonesia. ( 28091778 )
2017
14
An update on epidemiology of congenital rubella syndrome: how far from the World Health Organization goals? ( 28728344 )
2017
15
Sensory defects and developmental delay among children with congenital rubella syndrome. ( 28406248 )
2017
16
Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review. ( 28115948 )
2016
17
A case of congenital rubella syndrome and infection in South-East London in 2015: prevention, diagnosis, and the public health response. ( 27884915 )
2016
18
Congenital rubella syndrome with death from interstitial pneumonia. ( 26840886 )
2016
19
Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome. ( 26870820 )
2016
20
Localization of Viral Antigens Improves Understanding of Congenital Rubella Syndrome Pathophysiology. ( 26870811 )
2016
21
Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. ( 27002428 )
2016
22
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. ( 27757248 )
2016
23
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. ( 27606025 )
2016
24
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania. ( 27225802 )
2016
25
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy. ( 27866768 )
2016
26
Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review. ( 26962867 )
2016
27
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? ( 27343317 )
2016
28
Using the two-source capture-recapture method to estimate the incidence and case ascertainment of congenital rubella syndrome in Australia, 1993-2013. ( 27757254 )
2016
29
Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. ( 27244797 )
2016
30
Vaccination in secondary school students expedites rubella control and prevents congenital rubella syndrome. ( 27899091 )
2016
31
Congenital Rubella. ( 27732820 )
2016
32
Prevalence of glaucoma and cataract morphology in congenital rubella syndrome. ( 25840326 )
2015
33
50 Years Ago in The Journal of Pediatrics: Congenital Rubella Syndrome: New Clinical Aspects with Recovery of Virus from Affected Infants. ( 26210840 )
2015
34
Intracranial epidural hematoma in a newborn with DIC secondary to congenital rubella. ( 26834916 )
2015
35
Congenital rubella still a public health problem in Italy: analysis of national surveillance data from 2005 to 2013. ( 25953272 )
2015
36
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989. ( 26469722 )
2015
37
[Epidemiologic Surveillance on Measles, Rubella and Congenital Rubella Syndrome. Spain]. ( 26580792 )
2015
38
Global Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination - 2000-2014. ( 26401958 )
2015
39
Congenital rubella syndrome: a matter of concern. ( 25988255 )
2015
40
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2014. ( 26410894 )
2015
41
Surveillance of congenital rubella and rubella infections in pregnancy in EU/EEA countries, 2012: Current status and future perspective to monitor elimination. ( 26209837 )
2015
42
Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome. ( 26350479 )
2015
43
Further efforts in the achievement of congenital rubella syndrome/rubella elimination. ( 25483539 )
2015
44
Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis. ( 26137534 )
2015
45
Dental manifestations of congenital rubella syndrome. ( 25721843 )
2015
46
Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. ( 25785205 )
2015
47
Violaceous Maculopapular Rash in a Newborn: Congenital Rubella Syndrome. ( 26538723 )
2015
48
Successful elimination of rubella and congenital rubella syndrome from the American region: A historical breakthrough. ( 26664432 )
2015
49
Epidemiological characteristics of rubella and congenital rubella syndrome in the 2012-2013 epidemics in Tokyo, Japan. ( 25672351 )
2015
50
An epidemiological assessment towards elimination of rubella and congenital rubella syndrome in Singapore. ( 25887085 )
2015

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG UNG

GO Terms for Congenital Rubella

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 CAT CD40LG
2 response to oxidative stress GO:0006979 9.26 CAT TPO
3 cellular oxidant detoxification GO:0098869 9.16 CAT TPO
4 negative regulation of apoptotic process GO:0043066 9.13 CAT CD40LG UNG
5 hydrogen peroxide catabolic process GO:0042744 8.62 CAT TPO

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 CAT TPO
2 peroxidase activity GO:0004601 8.62 CAT TPO

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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