CRS
MCID: CNG124
MIFTS: 57

Congenital Rubella (CRS) malady

Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases, Skin diseases categories

Summaries for Congenital Rubella

About this section
Sources:
4CDC, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
CDC:4 NIOSH Pocket Guide to Chemical HazardsExposure limits, Respirator Recommendations, First Aid, more...The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards: Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and diabetes mellitus, and has symptoms including hypotonia, thrombocytopenia/thrombopenia and anophthalmos/anophthalmia/microphthalmos/microphthalmia. An important gene associated with Congenital Rubella is UNG (uracil-DNA glycosylase), and among its related pathways are Glucose / Energy Metabolism and Primary immunodeficiency. The compounds deoxyribose and hypoxanthine have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and t cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:66 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Aliases & Classifications for Congenital Rubella

About this section
Sources:
44NIH Rare Diseases, 50Orphanet, 40NCBI Bookshelf, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

50
congenital rubella syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

congenital rubella 44
congenital rubella syndrome 44 50 63
crs 44 40
rubella congenital 44
craniosynostosis 63


External Ids:

MESH via Orphanet37 D012410
ICD10 via Orphanet27 P35.0
SNOMED-CT via Orphanet60 1857005
UMLS via Orphanet64 C0035921
ICD1026 P35.0

Related Diseases for Congenital Rubella

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to congenital rubella

Symptoms for Congenital Rubella

About this section
Sources:
50Orphanet
See all sources


Symptoms:

50 (show all 32)
  • hypotonia
  • thrombocytopenia/thrombopenia
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • intrauterine growth retardation
  • glaucoma
  • large fontanelle/delayed fontanelle closure
  • ventricular septal defect/interventricular communication
  • pulmonary artery stenosis/absence/hypoplasia of the pulmonary branches
  • aniridia/iris hypoplasia
  • antenatal exposure : rubella
  • atrial septal defect/interauricular communication
  • patent ductus arteriosus
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • cataract/lens opacification
  • corneal clouding/opacity/vascularisation
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • nystagmus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • seizures/epilepsy/absences/spasms/status epilepticus
  • retinitis pigmentosa/retinal pigmentary changes
  • sensorineural deafness/hearing loss
  • short stature/dwarfism/nanism
  • strabismus/squint
  • metaphyseal anomaly
  • cutaneous rash
  • anaemia
  • hepatitis/icterus/cholestasis
  • insulin-dependent/type 1 diabetes
  • visual loss/blindness/amblyopia
  • microcephaly
  • hypertonia/spasticity/rigidity/stiffness

Drugs & Therapeutics for Congenital Rubella

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Congenital Rubella

Drug clinical trials:

Search ClinicalTrials for Congenital Rubella

Search NIH Clinical Center for Congenital Rubella

Search CenterWatch for Congenital Rubella

Genetic Tests for Congenital Rubella

About this section

Anatomical Context for Congenital Rubella

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Congenital Rubella:

34
Liver, Thyroid, T cells, Brain, Eye, Testes, Salivary gland, Skin, Heart, Placenta, Endothelial

Animal Models for Congenital Rubella or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Congenital Rubella:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1CD40LG, GAD2, TPO, UNG
2MP:00053767.4CD40LG, GAD2, CAT, TPO, UNG
3MP:00107687.2UNG, TPO, CAT, GAD2, CD40LG

Publications for Congenital Rubella

About this section
Sources:
53PubMed
See all sources

Articles related to Congenital Rubella:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
Congenital rubella syndrome: a review of laboratory data from 2002 to 2011. (24050074)
2013
2
Ongoing outbreak of rubella among young male adults in Poland: increased risk of congenital rubella infections. (23725976)
2013
3
Case report: congenital rubella syndrome: a rare but persistent concern in the United States. (24169928)
2013
4
Congenital rubella syndrome and left pulmonary artery sling. (22298614)
2012
5
Letter to the editor: commitment needed for the prevention of congenital rubella syndrome in Europe. (22433598)
2012
6
Congenital rubella syndrome: a continuing conundrum. (22633034)
2012
7
Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination--United States, 2001-2010. (21592401)
2011
8
Surveillance and control of rubella in the republic of Korea from 2001 to 2009: the necessity for enhanced surveillance to monitor congenital rubella syndrome. (24159436)
2010
9
Congenital rubella syndrome with autistic disorder. (20171592)
2010
10
Antenatal diagnostic problem of congenital rubella. (20091360)
2010
11
Prevention of congenital rubella and congenital varicella in Europe. (19371507)
2009
12
Prevention of congenital rubella and congenital varicella in Europe. (19317971)
2009
13
Active surveillance for congenital rubella syndrome in Yangon, Myanmar. (16501710)
2006
14
In vivo confocal microscopy in congenital rubella keratopathy. (15803165)
2006
15
The epidemiological profile of rubella and congenital rubella syndrome in the United States, 1998-2004: the evidence for absence of endemic transmission. (16998771)
2006
16
Frontal-dominant white matter lesions following congenital rubella and cytomegalovirus infection. (16602852)
2006
17
Progress toward elimination of measles and prevention of congenital rubella infection--European region, 1990-2004. (15729220)
2005
18
Accelerated control of rubella and prevention of congenital rubella syndrome, WHO Region of the Americas. (12696443)
2003
19
Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. (12824690)
2003
20
Incidence of congenital rubella syndrome at a hospital serving a predominantly Hispanic population, El Paso, Texas. (11230621)
2001
21
Prevention of congenital rubella syndrome. (20212977)
1999
22
The epidemiology of rubella and congenital rubella in Australia, 1992 to 1997. (10497832)
1999
23
Use of PCR for prenatal and postnatal diagnosis of congenital rubella. (8576339)
1995
24
Congenital rubella syndrome. (8110709)
1994
25
Rubella surveillance to december 1990: a joint report from the PHLS and National Congenital Rubella Surveillance Programme. (1669769)
1991
26
Increase in rubella and congenital rubella syndrome--United States, 1988-1990. (1899464)
1991
27
Gregg and congenital rubella: lessons from history and clinical research. (1789960)
1991
28
Congenital rubella syndrome in the United States, 1970-1985. On the verge of elimination. (2912045)
1989
29
Ventriculitis in congenital rubella: ultrasound demonstration. (3306592)
1987
30
Congenital rubella syndrome in Malaysia. (3831727)
1985
31
Delayed manifestations of congenital rubella. (4001724)
1985
32
Congenital rubella syndrome in Nova Scotia. (4027829)
1985
33
Birth and death of congenital rubella syndrome. (6700106)
1984
34
Rubella and congenital rubella surveillance, 1983. (6443222)
1984
35
Preventing the congenital rubella syndrome by vaccinating women at risk. (6861052)
1983
36
The HLA system in congenital rubella patients with and without diabetes. (6959935)
1982
37
Congenital rubella syndrome: a continuing problem. (6799666)
1982
38
Congenital rubella, insulitis, and diabetes mellitus in an infant. (6112424)
1981
39
Keratoconus and acute hydrops in mentally retarded patients with congenital rubella syndrome. (7468739)
1981
40
Congenital rubella in an Indochinese refugee in Manitoba. (20313556)
1981
41
Impaired cell-mediated immune response in patients with congenital rubella: correlation with gestational age at time of infection. (386238)
1979
42
The devastating effects of congenital rubella. (106205)
1979
43
Behavioral consequences of congenital rubella. (702254)
1978
44
Nuclear and cytoplasmic immunofluorescence in the cerebrospinal fluid cells from a neonate with congenital rubella. (347227)
1977
45
Congenital rubella: the teenage years. (579450)
1977
46
Follow-up report on autism in congenital rubella. (576606)
1977
47
Prenatal diagnosis of congenital rubella. (843835)
1977
48
Congenital rubella--an encapsulated review. (960007)
1976
49
Impaired cellular immunity to rubella virus in congenital rubella. (4808855)
1974
50
Aqueductal occlusion in the congenital rubella syndrome. (4543944)
1974

Variations for Congenital Rubella

About this section

Expression for genes affiliated with Congenital Rubella

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for genes affiliated with Congenital Rubella

About this section
Sources:
51PathCards, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
See all sources

Compounds for genes affiliated with Congenital Rubella

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR
See all sources

Compounds related to Congenital Rubella according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1deoxyribose46 2510.9UNG, CAT
2hypoxanthine46 25 1211.8CAT, UNG
3cytidine46 25 1211.7CD40LG, UNG
4levodopa46 1210.7GAD2, CAT
5guaiacol46 2510.5CAT, TPO
6maltose46 1210.5TPO, GAD2
7125i469.5TPO, GAD2
8mannitol46 1210.5CD40LG, CAT
9Hydrogen peroxide259.5TPO, CAT
10selenium46 2510.4CAT, TPO
11c-peptide469.4GAD2, TPO
12uric acid46 2510.4CAT, TPO
13cardiolipin46 1210.4CD40LG, TPO
14formaldehyde46 2510.3CD40LG, CAT
15dithiothreitol469.3TPO, CAT
16vitamin a46 25 1211.3CD40LG, CAT
17agarose469.3TPO, UNG
18folate469.3CD40LG, UNG
19tetracycline46 1210.3CD40LG, TPO
20thyroxine46 2510.1TPO, CD40LG
21hydrogen46 2510.0GAD2, TPO, UNG
22cycloheximide469.0UNG, TPO, CAT
23h2o2469.0CAT, TPO, UNG
24oligonucleotide468.9UNG, TPO, GAD2
25gliadin468.9CD40LG, GAD2, TPO
26ascorbic acid46 259.9CD40LG, CAT, TPO
27acetylcholine46 52 30 25 1212.9CD40LG, GAD2, TPO
28heme30 25 1210.8CAT, TPO
29nitric oxide46 25 1210.8GAD2, CAT, TPO
30glutamate468.4UNG, TPO, GAD2, CD40LG
31cysteine468.4CD40LG, GAD2, CAT, TPO

GO Terms for genes affiliated with Congenital Rubella

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.0CD40LG, GAD2, CAT, TPO

Biological processes related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:0430668.9CD40LG, CAT, UNG
2hydrogen peroxide catabolic processGO:0427448.8CAT, TPO

Molecular functions related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.1CAT, TPO

Products for genes affiliated with Congenital Rubella

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Rubella

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet