CRS
MCID: CNG124
MIFTS: 42

Congenital Rubella (CRS) malady

Fetal diseases, Neuronal diseases, Infectious diseases categories

Summaries for Congenital Rubella

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3CDC, 63Wikipedia, 32MalaCards
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MalaCards: Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and measles, and has symptoms including cutaneous rash, metaphyseal anomaly and strabismus/squint. An important gene associated with Congenital Rubella is UNG (uracil-DNA glycosylase), and among its related pathways is Regulation of thyroid hormone activity. The compounds selenium and hydrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Wikipedia:63 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Aliases & Classifications for Congenital Rubella

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Sources:
42NIH Rare Diseases, 48Orphanet, 38NCBI Bookshelf, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
congenital rubella syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

congenital rubella 42
congenital rubella syndrome 42 48 60
crs 42 38
rubella congenital 42
craniosynostosis 60


External Ids:

MESH via Orphanet35 D012410
ICD10 via Orphanet26 P35.0
SNOMED-CT via Orphanet57 1857005
UMLS via Orphanet61 C0035921
ICD1025 P35.0

Related Diseases for Congenital Rubella

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17GeneCards, 18GeneDecks
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Diseases in the Rubella family:

congenital rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1rubella31.9CD40LG
2measles30.9CD40LG
3diabetes mellitus30.6CD40LG, GAD2, CAT
4thyroiditis30.3TPO, GAD2
5encephalitis30.1CAT, GAD2
6vasculitis29.9CD40LG
7acute myocardial infarction29.8CAT
8congenital heart defect29.6CAT, CD40LG
9muenke syndrome10.4
10shprintzen-goldberg syndrome10.4
11cataract10.4
12baller-gerold syndrome10.4
13synostosis10.4
14saethre-chotzen syndrome10.3
15crouzon syndrome10.3
16craniosynostosis, type 110.2
17mumps10.2
18fgfr-related craniosynostosis syndromes10.2
19craniosynostosis, type 210.2
20craniosynostosis 410.2
21syndactyly10.2
22acrocephalosyndactylia10.2
23papilledema10.2
24jackson-weiss syndrome10.2
25genoa syndrome10.2
26hunter-mcalpine syndrome10.2
27herrmann opitz craniosynostosis10.2
28craniosynostosis and dental anomalies10.2
29microcephaly10.1
30craniosynostosis, anal anomalies, and porokeratosis10.1
31craniosynostosis philadelphia type10.1
32dandy-walker malformation with sagittal craniosynostosis and hydrocephalus10.1
33goldberg-shprintzen megacolon syndrome10.1
34craniosynostosis 310.1
35craniosynostosis - dandy-walker malformation - hydrocephalus10.1
36encephalomyelitis10.1
37leukemia10.1
38congenital hypothyroidism10.1
39hydranencephaly10.1
40hypothyroidism10.1
41keratoconus10.1
42brachydactyly10.1
43rickets10.1
44infectious mononucleosis10.1
45pycnodysostosis10.1
46holoprosencephaly10.1
47hydrocephalus10.1
48strabismus10.1
49parkinson's disease10.0
50limited scleroderma10.0

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to congenital rubella

Clinical Features for Congenital Rubella

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48Orphanet
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Symptoms:

48 (show all 32)
  • cutaneous rash
  • metaphyseal anomaly
  • strabismus/squint
  • patent ductus arteriosus
  • atrial septal defect/interauricular communication
  • thrombocytopenia/thrombopenia
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • intrauterine growth retardation
  • glaucoma
  • large fontanelle/delayed fontanelle closure
  • ventricular septal defect/interventricular communication
  • pulmonary artery stenosis/absence/hypoplasia of the pulmonary branches
  • aniridia/iris hypoplasia
  • antenatal exposure : rubella
  • anaemia
  • hepatitis/icterus/cholestasis
  • insulin-dependent/type 1 diabetes
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • nystagmus
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • hypotonia
  • corneal clouding/opacity/vascularisation
  • cataract/lens opacification
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • retinitis pigmentosa/retinal pigmentary changes
  • sensorineural deafness/hearing loss
  • short stature/dwarfism/nanism
  • microcephaly
  • visual loss/blindness/amblyopia
  • hypertonia/spasticity/rigidity/stiffness

Drugs & Therapeutics for Congenital Rubella

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Congenital Rubella

Drug clinical trials:

Search ClinicalTrials for Congenital Rubella

Search NIH Clinical Center for Congenital Rubella

Search CenterWatch for Congenital Rubella

Genetic Tests for Congenital Rubella

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Anatomical Context for Congenital Rubella

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32MalaCards
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MalaCards organs/tissues related to Congenital Rubella:

32
Liver

Animal Models for Congenital Rubella or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Congenital Rubella:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5CAT, UNG, GAD2, CD40LG, TPO
2MP:00053767.2CAT, UNG, GAD2, CD40LG, TPO

Publications for Congenital Rubella

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Genetic Variations for Congenital Rubella

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Expression for genes affiliated with Congenital Rubella

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for genes affiliated with Congenital Rubella

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Sources:
53Reactome, 37NCBI BioSystems Database
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Pathways related to Congenital Rubella according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3TPO, GAD2

Compounds for genes affiliated with Congenital Rubella

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Congenital Rubella according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1selenium44 2411.2CAT
2hydrogen44 2411.1TPO
3deoxyribose44 2410.8UNG, CAT
4hypoxanthine44 11 2411.8UNG, CAT
5guaiacol44 2410.7TPO, CAT
6maltose44 1110.7GAD2, TPO
7125i449.6GAD2, TPO
8c-peptide449.5GAD2, TPO
9levodopa44 1110.5CAT, GAD2
10cytidine44 11 2411.5UNG, CD40LG
11uric acid44 2410.4CAT, TPO
12cardiolipin44 1110.3CD40LG, TPO
13dithiothreitol449.2CAT, TPO
14tetracycline44 1110.2TPO, CD40LG
15cycloheximide449.1CAT, UNG, TPO
16h2o2449.1TPO, CAT, UNG
17oligonucleotide448.9UNG, GAD2, TPO
18gliadin448.9TPO, CD40LG, GAD2
19mannitol44 119.8CAT, CD40LG
20ascorbic acid44 249.8TPO, CD40LG, CAT
21acetylcholine44 49 28 11 2412.8TPO, CD40LG, GAD2
22nitric oxide44 11 2410.8CAT, GAD2, TPO
23glutamate448.4GAD2, UNG, TPO, CD40LG
24cysteine448.3TPO, CD40LG, CAT, GAD2

GO Terms for genes affiliated with Congenital Rubella

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16Gene Ontology
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Biological processes related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hydrogen peroxide catabolic processGO:0427449.3TPO, CAT

Products for genes affiliated with Congenital Rubella

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Rubella

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet