MCID: CNG124
MIFTS: 40

Congenital Rubella malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Congenital Rubella

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Sources:
29ICD10, 30ICD10 via Orphanet, 39MESH via Orphanet, 42NCBI Bookshelf, 47NIH Rare Diseases, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Congenital Rubella:

Name: Congenital Rubella 47
Congenital Rubella Syndrome 47 53 67
Crs 47 53 42
 
Fetal Rubella Syndrome 53
Rubella Congenital 47
Craniosynostosis 67

Characteristics:

Orphanet epidemiological data:

53
congenital rubella syndrome:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth

Classifications:



External Ids:

Orphanet53 ORPHA290
MESH via Orphanet39 D012410
UMLS via Orphanet68 C0035921
ICD10 via Orphanet30 P35.0
ICD1029 P35.0

Summaries for Congenital Rubella

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Wikipedia:70 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

MalaCards based summary: Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and measles, and has symptoms including sensorineural hearing impairment, cataract and intrauterine growth retardation. An important gene associated with Congenital Rubella is CAT (Catalase), and among its related pathways is Primary immunodeficiency. Affiliated tissues include skin, thyroid and eye, and related mouse phenotype homeostasis/metabolism.

Related Diseases for Congenital Rubella

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Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to congenital rubella

Symptoms for Congenital Rubella

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Human phenotypes related to Congenital Rubella:

 63 53 (show all 35)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sensorineural hearing impairment63 53 hallmark (90%) Very frequent (99-80%) HP:0000407
2 cataract63 53 hallmark (90%) Very frequent (99-80%) HP:0000518
3 intrauterine growth retardation63 53 hallmark (90%) Very frequent (99-80%) HP:0001511
4 neurological speech impairment63 53 hallmark (90%) Very frequent (99-80%) HP:0002167
5 abnormality of the fontanelles or cranial sutures63 53 typical (50%) Frequent (79-30%) HP:0000235
6 microcephaly63 53 typical (50%) Frequent (79-30%) HP:0000252
7 strabismus63 53 typical (50%) Frequent (79-30%) HP:0000486
8 glaucoma63 53 typical (50%) Frequent (79-30%) HP:0000501
9 visual impairment63 53 typical (50%) Frequent (79-30%) HP:0000505
10 nystagmus63 53 typical (50%) Frequent (79-30%) HP:0000639
11 skin rash63 53 typical (50%) Frequent (79-30%) HP:0000988
12 muscular hypotonia63 53 typical (50%) Frequent (79-30%) HP:0001252
13 hypertonia63 typical (50%) HP:0001276
14 ventricular septal defect63 53 typical (50%) Frequent (79-30%) HP:0001629
15 atria septal defect63 typical (50%) HP:0001631
16 patent ductus arteriosus63 53 typical (50%) Frequent (79-30%) HP:0001643
17 splenomegaly63 53 typical (50%) Frequent (79-30%) HP:0001744
18 thrombocytopenia63 53 typical (50%) Frequent (79-30%) HP:0001873
19 anemia63 53 typical (50%) Frequent (79-30%) HP:0001903
20 hepatomegaly63 53 typical (50%) Frequent (79-30%) HP:0002240
21 short stature63 53 typical (50%) Frequent (79-30%) HP:0004322
22 abnormality of the pulmonary artery63 53 typical (50%) Frequent (79-30%) HP:0004414
23 abnormality of retinal pigmentation63 53 typical (50%) Frequent (79-30%) HP:0007703
24 aplasia/hypoplasia of the iris63 53 typical (50%) Frequent (79-30%) HP:0008053
25 cognitive impairment63 typical (50%) HP:0100543
26 abnormality of the metaphyses63 53 occasional (7.5%) Occasional (29-5%) HP:0000944
27 seizures63 53 occasional (7.5%) Occasional (29-5%) HP:0001250
28 opacification of the corneal stroma63 occasional (7.5%) HP:0007759
29 type i diabetes mellitus63 53 occasional (7.5%) Occasional (29-5%) HP:0100651
30 microphthalmia53 Frequent (79-30%)
31 jaundice53 Occasional (29-5%)
32 intellectual disability53 Frequent (79-30%)
33 spastic diplegia53 Frequent (79-30%)
34 defect in the atrial septum53 Frequent (79-30%)
35 corneal opacity53 Occasional (29-5%)

Drugs & Therapeutics for Congenital Rubella

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Susceptibility Genes in Autism Spectrum DisordersRecruitingNCT02628808
2Expanded Noninvasive Genomic Medical Assessment: The Enigma StudyRecruitingNCT02787486

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

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Anatomical Context for Congenital Rubella

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MalaCards organs/tissues related to Congenital Rubella:

35
Skin, Thyroid, Eye, T cells, Testes, Brain, Endothelial

Animal Models for Congenital Rubella or affiliated genes

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MGI Mouse Phenotypes related to Congenital Rubella:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0CAT, CD40LG, TPO, UNG

Publications for Congenital Rubella

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Articles related to Congenital Rubella:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. (27757248)
2016
2
Epidemiologic Surveillance on Measles, Rubella and Congenital Rubella Syndrome. Spain]. (26580792)
2015
3
Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. (25785205)
2015
4
Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis. (26137534)
2015
5
Congenital rubella syndrome: a review of laboratory data from 2002 to 2011. (24050074)
2013
6
Implications of spatially heterogeneous vaccination coverage for the risk of congenital rubella syndrome in South Africa. (23152104)
2013
7
Letter to the editor: commitment needed for the prevention of congenital rubella syndrome in Europe. (22433598)
2012
8
Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination--United States, 2001-2010. (21592401)
2011
9
Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru. (20659931)
2011
10
Surveillance and control of rubella in the republic of Korea from 2001 to 2009: the necessity for enhanced surveillance to monitor congenital rubella syndrome. (24159436)
2010
11
Congenital rubella syndrome with autistic disorder. (20171592)
2010
12
Antenatal diagnostic problem of congenital rubella. (20091360)
2010
13
Prevention of congenital rubella and congenital varicella in Europe. (19371507)
2009
14
Prevention of congenital rubella and congenital varicella in Europe. (19317971)
2009
15
Prevention of congenital rubella syndrome. (19030469)
2007
16
Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome. (17516526)
2007
17
Prevalence of eye signs in congenital rubella syndrome in South India: a role for population screening. (17947267)
2007
18
Active surveillance for congenital rubella syndrome in Yangon, Myanmar. (16501710)
2006
19
In vivo confocal microscopy in congenital rubella keratopathy. (15803165)
2006
20
Frontal-dominant white matter lesions following congenital rubella and cytomegalovirus infection. (16602852)
2006
21
Forty-year observation of 280 Japanese patients with congenital rubella syndrome. (16123517)
2005
22
Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. (12824690)
2003
23
Congenital rubella: down but not out. (12241854)
2002
24
Congenital rubella syndrome in Haiti (Short communication). (12431359)
2002
25
Incidence of congenital rubella syndrome at a hospital serving a predominantly Hispanic population, El Paso, Texas. (11230621)
2001
26
Prevention of congenital rubella syndrome. (20212977)
1999
27
The epidemiology of rubella and congenital rubella in Australia, 1992 to 1997. (10497832)
1999
28
Circumscribed scleroderma in congenital rubella syndrome with hypogammaglobulinemia. (9821485)
1998
29
Use of PCR for prenatal and postnatal diagnosis of congenital rubella. (8576339)
1995
30
Congenital rubella syndrome. (8110709)
1994
31
Increase in rubella and congenital rubella syndrome--United States, 1988-1990. (1899464)
1991
32
Gregg and congenital rubella: lessons from history and clinical research. (1789960)
1991
33
Ventriculitis in congenital rubella: ultrasound demonstration. (3306592)
1987
34
Congenital rubella syndrome in Malaysia. (3831727)
1985
35
Delayed manifestations of congenital rubella. (4001724)
1985
36
Congenital rubella syndrome in Nova Scotia. (4027829)
1985
37
Epidemiology of congenital rubella and results of rubella vaccination in Australia. (3890106)
1985
38
Epidemiology of prenatal infections: an extension of the congenital rubella model. (6648116)
1983
39
The HLA system in congenital rubella patients with and without diabetes. (6959935)
1982
40
Congenital rubella syndrome: a continuing problem. (6799666)
1982
41
Congenital rubella after successful vaccination. (7099094)
1982
42
Keratoconus and acute hydrops in mentally retarded patients with congenital rubella syndrome. (7468739)
1981
43
Congenital rubella in an Indochinese refugee in Manitoba. (20313556)
1981
44
The devastating effects of congenital rubella. (106205)
1979
45
Behavioral consequences of congenital rubella. (702254)
1978
46
Nuclear and cytoplasmic immunofluorescence in the cerebrospinal fluid cells from a neonate with congenital rubella. (347227)
1977
47
Prenatal diagnosis of congenital rubella. (843835)
1977
48
Diabetes mellitus and congenital rubella: report of a case. (302908)
1977
49
Congenital rubella--an encapsulated review. (960007)
1976
50
Aqueductal occlusion in the congenital rubella syndrome. (4543944)
1974

Variations for Congenital Rubella

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Expression for genes affiliated with Congenital Rubella

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Search GEO for disease gene expression data for Congenital Rubella.

Pathways for genes affiliated with Congenital Rubella

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Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3CD40LG, UNG

GO Terms for genes affiliated with Congenital Rubella

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Cellular components related to Congenital Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5CAT, CD40LG, TPO
2mitochondrionGO:00057398.3CAT, TPO, UNG

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hydrogen peroxide catabolic processGO:00427449.6CAT, TPO
2positive regulation of NF-kappaB transcription factor activityGO:00510929.5CAT, CD40LG
3cellular oxidant detoxificationGO:00988699.5CAT, TPO
4negative regulation of apoptotic processGO:00430668.8CAT, CD40LG, UNG

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.1CAT, TPO

Sources for Congenital Rubella

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet