CRS
MCID: CNG124
MIFTS: 44

Congenital Rubella (CRS) malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Congenital Rubella

About this section
Sources:
30ICD10, 31ICD10 via Orphanet, 40MESH via Orphanet, 43NCBI Bookshelf, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Congenital Rubella:

Name: Congenital Rubella 48
Congenital Rubella Syndrome 48 54 68
Crs 48 54 43
 
Fetal Rubella Syndrome 54
Rubella Congenital 48

Characteristics:

Orphanet epidemiological data:

54
congenital rubella syndrome:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth

Classifications:



External Ids:

Orphanet54 ORPHA290
MESH via Orphanet40 D012410
UMLS via Orphanet69 C0035921
ICD10 via Orphanet31 P35.0
ICD1030 P35.0

Summaries for Congenital Rubella

About this section
Wikipedia:71 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

MalaCards based summary: Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and measles, and has symptoms including Array, Array and Array. An important gene associated with Congenital Rubella is CD40LG (CD40 Ligand), and among its related pathways are Primary immunodeficiency and Allograft rejection. Affiliated tissues include skin, thyroid and eye, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Related Diseases for Congenital Rubella

About this section

Diseases in the Rubella family:

congenital rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1rubella11.5
2measles10.2
3hyperparathyroidism, primary, caused by water clear cell hyperplasia10.1CD40LG, UNG
4hypoparathyroidism, x-linked10.1CD40LG, UNG
5cataract10.1
6abdominal tuberculosis10.0CALR, CD40LG
7temtamy syndrome10.0CD40LG, UNG
8type 2 papillary adenoma of the kidney10.0CD40LG, UNG
9chromosome 17q23.1-q23.2 deletion syndrome9.9CALR, CAT
10articulation disorder9.9CD40LG, TPO
11drug psychosis9.9CAT, CD40LG
12pseudohypoparathyroidism9.9CAT, CD40LG
13cytomegalovirus infection9.9
14parasitic helminthiasis infectious disease9.8CALR, CD40LG, TPO
15testicular lymphoma9.8CD40LG, TPO
16inflammatory bowel disease 39.8CALR, CD40LG, TPO
17mumps9.8
18thyroiditis9.8
19encephalitis9.8
20nail disorder, nonsyndromic congenital, 79.8CAT, TPO
21pulmonary hypertension9.7
22keratoconus9.7
23hypothyroidism9.7
24hydranencephaly9.7
25pneumonia9.7
26hashimoto thyroiditis9.6
27wolff-parkinson-white syndrome9.6
28cryptorchidism9.6
29jejunal atresia9.6
30autistic disorder9.6
31hemolytic anemia9.6
32keratopathy9.6
33autism spectrum disorder9.6
34corneal edema9.6
35heart disease9.6
36myxedema9.6
37dysgammaglobulinemia9.6
38esophagitis9.6
39uveitis9.6
40patent ductus arteriosus9.6
41encephalomalacia9.6
42pancreatitis9.6
43viral esophagitis9.6
44hyperthyroidism9.6
45duodenitis9.6
46vasculitis9.6
47toxoplasmosis9.6
48central serous chorioretinopathy9.6
49growth hormone deficiency9.6
50tracheoesophageal fistula9.6

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to congenital rubella

Symptoms & Phenotypes for Congenital Rubella

About this section

Human phenotypes related to Congenital Rubella:

 54 64 (show all 32)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the fontanelles or cranial sutures64 54 Frequent (79-30%) HP:0000235
2 microcephaly64 54 Frequent (79-30%) HP:0000252
3 sensorineural hearing impairment64 54 Very frequent (99-80%) HP:0000407
4 strabismus64 54 Frequent (79-30%) HP:0000486
5 glaucoma64 54 Frequent (79-30%) HP:0000501
6 visual impairment64 54 Frequent (79-30%) HP:0000505
7 cataract64 54 Very frequent (99-80%) HP:0000518
8 microphthalmia64 54 Frequent (79-30%) HP:0000568
9 nystagmus64 54 Frequent (79-30%) HP:0000639
10 abnormality of the metaphyses64 54 Occasional (29-5%) HP:0000944
11 jaundice64 54 Occasional (29-5%) HP:0000952
12 skin rash64 54 Frequent (79-30%) HP:0000988
13 intellectual disability64 54 Frequent (79-30%) HP:0001249
14 seizures64 54 Occasional (29-5%) HP:0001250
15 muscular hypotonia64 54 Frequent (79-30%) HP:0001252
16 spastic diplegia64 54 Frequent (79-30%) HP:0001264
17 intrauterine growth retardation64 54 Very frequent (99-80%) HP:0001511
18 ventricular septal defect64 54 Frequent (79-30%) HP:0001629
19 atria septal defect54 Frequent (79-30%)
20 patent ductus arteriosus64 54 Frequent (79-30%) HP:0001643
21 splenomegaly64 54 Frequent (79-30%) HP:0001744
22 thrombocytopenia64 54 Frequent (79-30%) HP:0001873
23 anemia64 54 Frequent (79-30%) HP:0001903
24 neurological speech impairment64 54 Very frequent (99-80%) HP:0002167
25 hepatomegaly64 54 Frequent (79-30%) HP:0002240
26 short stature64 54 Frequent (79-30%) HP:0004322
27 abnormality of the pulmonary artery64 54 Frequent (79-30%) HP:0004414
28 abnormality of retinal pigmentation64 54 Frequent (79-30%) HP:0007703
29 corneal opacity64 54 Occasional (29-5%) HP:0007957
30 aplasia/hypoplasia of the iris64 54 Frequent (79-30%) HP:0008053
31 type i diabetes mellitus64 54 Occasional (29-5%) HP:0100651
32 atrial septal defect64 HP:0001631

MGI Mouse Phenotypes related to Congenital Rubella according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.3CALR, CAT, CD40LG, TPO, UNG
2MP:00107687.5CALR, CAT, CD40LG, TPO, UNG

Drugs & Therapeutics for Congenital Rubella

About this section

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 46611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of AgeNot yet recruitingNCT03071575Phase 4
2Susceptibility Genes in Autism Spectrum DisordersRecruitingNCT02628808
3Expanded Noninvasive Genomic Medical Assessment: The Enigma StudyRecruitingNCT02787486

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

About this section

Anatomical Context for Congenital Rubella

About this section

MalaCards organs/tissues related to Congenital Rubella:

36
Skin, Thyroid, Eye, T cells, Testes, Brain, Endothelial

Publications for Congenital Rubella

About this section

Articles related to Congenital Rubella:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Hospital-based surveillance of congenital rubella syndrome in Indonesia. (28091778)
2017
2
The end of measles and congenital rubella: an achievable dream? (28067934)
2017
3
Congenital Rubella. (27732820)
2016
4
Using the two-source capture-recapture method to estimate the incidence and case ascertainment of congenital rubella syndrome in Australia, 1993-2013. (27757254)
2016
5
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy. (27866768)
2016
6
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. (27757248)
2016
7
Vaccination in secondary school students expedites rubella control and prevents congenital rubella syndrome. (27899091)
2016
8
Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. (27244797)
2016
9
Localization of Viral Antigens Improves Understanding of Congenital Rubella Syndrome Pathophysiology. (26870811)
2016
10
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. (27606025)
2016
11
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? (27343317)
2016
12
A case of congenital rubella syndrome and infection in South-East London in 2015: prevention, diagnosis, and the public health response. (27884915)
2016
13
Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. (27002428)
2016
14
Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review. (26962867)
2016
15
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania. (27225802)
2016
16
Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome. (26870820)
2016
17
Congenital rubella syndrome with death from interstitial pneumonia. (26840886)
2016
18
Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome. (26350479)
2015
19
An epidemiological assessment towards elimination of rubella and congenital rubella syndrome in Singapore. (25887085)
2015
20
Congenital rubella syndrome (CRS) in Vietnam 2011-2012--CRS epidemic after rubella epidemic in 2010-2011. (26087296)
2015
21
Epidemiologic Surveillance on Measles, Rubella and Congenital Rubella Syndrome. Spain]. (26580792)
2015
22
Further efforts in the achievement of congenital rubella syndrome/rubella elimination. (25483539)
2015
23
Epidemiological characteristics of rubella and congenital rubella syndrome in the 2012-2013 epidemics in Tokyo, Japan. (25672351)
2015
24
Congenital rubella syndrome: Global issue. (26049858)
2015
25
Violaceous Maculopapular Rash in a Newborn: Congenital Rubella Syndrome. (26538723)
2015
26
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2014. (26410894)
2015
27
Congenital rubella still a public health problem in Italy: analysis of national surveillance data from 2005 to 2013. (25953272)
2015
28
Congenital rubella syndrome: a matter of concern. (25988255)
2015
29
Successful elimination of rubella and congenital rubella syndrome from the American region: A historical breakthrough. (26664432)
2015
30
Intracranial epidural hematoma in a newborn with DIC secondary to congenital rubella. (26834916)
2015
31
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989. (26469722)
2015
32
Shedding of Rubella Virus in Congenital Rubella Syndrome: Study of Affected Infants Born in Tokyo, Japan, 2013-2014. (26567831)
2015
33
50 Years Ago in The Journal of Pediatrics: Congenital Rubella Syndrome: New Clinical Aspects with Recovery of Virus from Affected Infants. (26210840)
2015
34
Surveillance of congenital rubella and rubella infections in pregnancy in EU/EEA countries, 2012: Current status and future perspective to monitor elimination. (26209837)
2015
35
Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis. (26137534)
2015
36
Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. (25785205)
2015
37
Prevalence of glaucoma and cataract morphology in congenital rubella syndrome. (25840326)
2015
38
Global Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination - 2000-2014. (26401958)
2015
39
Dental manifestations of congenital rubella syndrome. (25721843)
2015
40
Identification of ocular and auditory manifestations of congenital rubella syndrome in mbingo. (25525427)
2014
41
Successful detection and genotyping of rubella virus from preserved umbilical cord of patients with congenital rubella syndrome. (25378458)
2014
42
Surveillance for congenital rubella in Australia since 1993: cases reported between 2004 and 2013. (25454858)
2014
43
Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability-Adjusted Life Years (DALYs). (25115193)
2014
44
Wolff-Parkinson-White Syndrome in Congenital Rubella Syndrome. (24567174)
2014
45
Short-term Prediction of the Incidence of Congenital Rubella Syndrome. (25642379)
2014
46
Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis. (25654000)
2014
47
Identification of congenital rubella syndrome in Sudan. (24898017)
2014
48
Congenital rubella syndrome in child of woman without known risk factors, New Jersey, USA. (24447409)
2014
49
Further efforts in the achievement of congenital rubella syndrome/rubella elimination: alternative sources of information for retrospective case-finding, Puglia region, Italy, 2003-2011. (25184620)
2014
50
Congenital rubella syndrome and immunity status of immigrant women living in southern Italy: a cross-sectional, seroepidemiological investigation. (24502919)
2014

Variations for Congenital Rubella

About this section

Expression for genes affiliated with Congenital Rubella

About this section
Search GEO for disease gene expression data for Congenital Rubella.

Pathways for genes affiliated with Congenital Rubella

About this section

GO Terms for genes affiliated with Congenital Rubella

About this section

Cellular components related to Congenital Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.6CALR, CD40LG, TPO
2extracellular spaceGO:00056158.1CALR, CAT, CD40LG, TPO

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of NF-kappaB transcription factor activityGO:00510929.8CAT, CD40LG
2cellular oxidant detoxificationGO:00988699.7CAT, TPO
3hydrogen peroxide catabolic processGO:00427449.7CAT, TPO
4response to estradiolGO:00323559.7CALR, CAT
5negative regulation of apoptotic processGO:00430669.3CAT, CD40LG, UNG
6response to oxidative stressGO:00069799.0CAT, TPO

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.4CAT, TPO
2peroxidase activityGO:00046019.0CAT, TPO

Sources for Congenital Rubella

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet