CRS
MCID: CNG124
MIFTS: 57

Congenital Rubella (CRS) malady

Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases, Skin diseases categories
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Summaries for Congenital Rubella

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4CDC, 65Wikipedia, 33MalaCards
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CDC:4 NIOSH Pocket Guide to Chemical HazardsExposure limits, Respirator Recommendations, First Aid, more...The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards: Congenital Rubella, also known as congenital rubella syndrome, is related to rubella and diabetes mellitus, and has symptoms including hypotonia, thrombocytopenia/thrombopenia and anophthalmos/anophthalmia/microphthalmos/microphthalmia. An important gene associated with Congenital Rubella is UNG (uracil-DNA glycosylase), and among its related pathways are Glucose / Energy Metabolism and Primary immunodeficiency. The compounds deoxyribose and hypoxanthine have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and t cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:65 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Aliases & Classifications for Congenital Rubella

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43NIH Rare Diseases, 49Orphanet, 39NCBI Bookshelf, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
congenital rubella syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

congenital rubella 43
congenital rubella syndrome 43 49 62
crs 43 39
rubella congenital 43
craniosynostosis 62


External Ids:

MESH via Orphanet36 D012410
ICD10 via Orphanet26 P35.0
SNOMED-CT via Orphanet59 1857005
UMLS via Orphanet63 C0035921
ICD1025 P35.0

Related Diseases for Congenital Rubella

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to congenital rubella

Symptoms for Congenital Rubella

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49Orphanet
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Symptoms:

49 (show all 32)
  • hypotonia
  • thrombocytopenia/thrombopenia
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • intrauterine growth retardation
  • glaucoma
  • large fontanelle/delayed fontanelle closure
  • ventricular septal defect/interventricular communication
  • pulmonary artery stenosis/absence/hypoplasia of the pulmonary branches
  • aniridia/iris hypoplasia
  • antenatal exposure : rubella
  • atrial septal defect/interauricular communication
  • patent ductus arteriosus
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • cataract/lens opacification
  • corneal clouding/opacity/vascularisation
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • nystagmus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • seizures/epilepsy/absences/spasms/status epilepticus
  • retinitis pigmentosa/retinal pigmentary changes
  • sensorineural deafness/hearing loss
  • short stature/dwarfism/nanism
  • strabismus/squint
  • metaphyseal anomaly
  • cutaneous rash
  • anaemia
  • hepatitis/icterus/cholestasis
  • insulin-dependent/type 1 diabetes
  • visual loss/blindness/amblyopia
  • microcephaly
  • hypertonia/spasticity/rigidity/stiffness

Drugs & Therapeutics for Congenital Rubella

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Congenital Rubella

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

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Anatomical Context for Congenital Rubella

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33MalaCards
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MalaCards organs/tissues related to Congenital Rubella:

33
Liver, Thyroid, T cells, Brain, Eye, Testes, Salivary gland, Skin, Heart, Placenta, Endothelial

Animal Models for Congenital Rubella or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Congenital Rubella:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1CD40LG, GAD2, TPO, UNG
2MP:00053767.4CD40LG, GAD2, CAT, TPO, UNG
3MP:00107687.2UNG, TPO, CAT, GAD2, CD40LG

Publications for Congenital Rubella

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52PubMed
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Articles related to Congenital Rubella:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
Congenital rubella syndrome: a review of laboratory data from 2002 to 2011. (24050074)
2013
2
Ongoing outbreak of rubella among young male adults in Poland: increased risk of congenital rubella infections. (23725976)
2013
3
Case report: congenital rubella syndrome: a rare but persistent concern in the United States. (24169928)
2013
4
Congenital rubella syndrome and left pulmonary artery sling. (22298614)
2012
5
Letter to the editor: commitment needed for the prevention of congenital rubella syndrome in Europe. (22433598)
2012
6
Congenital rubella syndrome: a continuing conundrum. (22633034)
2012
7
Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination--United States, 2001-2010. (21592401)
2011
8
Surveillance and control of rubella in the republic of Korea from 2001 to 2009: the necessity for enhanced surveillance to monitor congenital rubella syndrome. (24159436)
2010
9
Congenital rubella syndrome with autistic disorder. (20171592)
2010
10
Antenatal diagnostic problem of congenital rubella. (20091360)
2010
11
Prevention of congenital rubella and congenital varicella in Europe. (19371507)
2009
12
Prevention of congenital rubella and congenital varicella in Europe. (19317971)
2009
13
Active surveillance for congenital rubella syndrome in Yangon, Myanmar. (16501710)
2006
14
In vivo confocal microscopy in congenital rubella keratopathy. (15803165)
2006
15
The epidemiological profile of rubella and congenital rubella syndrome in the United States, 1998-2004: the evidence for absence of endemic transmission. (16998771)
2006
16
Frontal-dominant white matter lesions following congenital rubella and cytomegalovirus infection. (16602852)
2006
17
Progress toward elimination of measles and prevention of congenital rubella infection--European region, 1990-2004. (15729220)
2005
18
Accelerated control of rubella and prevention of congenital rubella syndrome, WHO Region of the Americas. (12696443)
2003
19
Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. (12824690)
2003
20
Incidence of congenital rubella syndrome at a hospital serving a predominantly Hispanic population, El Paso, Texas. (11230621)
2001
21
Prevention of congenital rubella syndrome. (20212977)
1999
22
The epidemiology of rubella and congenital rubella in Australia, 1992 to 1997. (10497832)
1999
23
Use of PCR for prenatal and postnatal diagnosis of congenital rubella. (8576339)
1995
24
Congenital rubella syndrome. (8110709)
1994
25
Rubella surveillance to december 1990: a joint report from the PHLS and National Congenital Rubella Surveillance Programme. (1669769)
1991
26
Increase in rubella and congenital rubella syndrome--United States, 1988-1990. (1899464)
1991
27
Gregg and congenital rubella: lessons from history and clinical research. (1789960)
1991
28
Congenital rubella syndrome in the United States, 1970-1985. On the verge of elimination. (2912045)
1989
29
Ventriculitis in congenital rubella: ultrasound demonstration. (3306592)
1987
30
Congenital rubella syndrome in Malaysia. (3831727)
1985
31
Delayed manifestations of congenital rubella. (4001724)
1985
32
Congenital rubella syndrome in Nova Scotia. (4027829)
1985
33
Birth and death of congenital rubella syndrome. (6700106)
1984
34
Rubella and congenital rubella surveillance, 1983. (6443222)
1984
35
Preventing the congenital rubella syndrome by vaccinating women at risk. (6861052)
1983
36
The HLA system in congenital rubella patients with and without diabetes. (6959935)
1982
37
Congenital rubella syndrome: a continuing problem. (6799666)
1982
38
Congenital rubella, insulitis, and diabetes mellitus in an infant. (6112424)
1981
39
Keratoconus and acute hydrops in mentally retarded patients with congenital rubella syndrome. (7468739)
1981
40
Congenital rubella in an Indochinese refugee in Manitoba. (20313556)
1981
41
Impaired cell-mediated immune response in patients with congenital rubella: correlation with gestational age at time of infection. (386238)
1979
42
The devastating effects of congenital rubella. (106205)
1979
43
Behavioral consequences of congenital rubella. (702254)
1978
44
Nuclear and cytoplasmic immunofluorescence in the cerebrospinal fluid cells from a neonate with congenital rubella. (347227)
1977
45
Congenital rubella: the teenage years. (579450)
1977
46
Follow-up report on autism in congenital rubella. (576606)
1977
47
Prenatal diagnosis of congenital rubella. (843835)
1977
48
Congenital rubella--an encapsulated review. (960007)
1976
49
Impaired cellular immunity to rubella virus in congenital rubella. (4808855)
1974
50
Aqueductal occlusion in the congenital rubella syndrome. (4543944)
1974

Variations for Congenital Rubella

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Expression for genes affiliated with Congenital Rubella

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for genes affiliated with Congenital Rubella

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50PathCards, 5Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
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Compounds for genes affiliated with Congenital Rubella

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Congenital Rubella according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1deoxyribose45 2410.9UNG, CAT
2hypoxanthine45 24 1111.8CAT, UNG
3cytidine45 24 1111.7CD40LG, UNG
4levodopa45 1110.7GAD2, CAT
5guaiacol45 2410.5CAT, TPO
6maltose45 1110.5TPO, GAD2
7125i459.5TPO, GAD2
8mannitol45 1110.5CD40LG, CAT
9Hydrogen peroxide249.5TPO, CAT
10selenium45 2410.4CAT, TPO
11c-peptide459.4GAD2, TPO
12uric acid45 2410.4CAT, TPO
13cardiolipin45 1110.4CD40LG, TPO
14formaldehyde45 2410.3CD40LG, CAT
15dithiothreitol459.3TPO, CAT
16vitamin a45 24 1111.3CD40LG, CAT
17agarose459.3TPO, UNG
18folate459.3CD40LG, UNG
19tetracycline45 1110.3CD40LG, TPO
20thyroxine45 2410.1TPO, CD40LG
21hydrogen45 2410.0GAD2, TPO, UNG
22cycloheximide459.0UNG, TPO, CAT
23h2o2459.0CAT, TPO, UNG
24oligonucleotide458.9UNG, TPO, GAD2
25gliadin458.9CD40LG, GAD2, TPO
26ascorbic acid45 249.9CD40LG, CAT, TPO
27acetylcholine45 51 29 24 1112.9CD40LG, GAD2, TPO
28heme29 24 1110.8CAT, TPO
29nitric oxide45 24 1110.8GAD2, CAT, TPO
30glutamate458.4UNG, TPO, GAD2, CD40LG
31cysteine458.4CD40LG, GAD2, CAT, TPO

GO Terms for genes affiliated with Congenital Rubella

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16Gene Ontology
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Cellular components related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.0CD40LG, GAD2, CAT, TPO

Biological processes related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:0430668.9CD40LG, CAT, UNG
2hydrogen peroxide catabolic processGO:0427448.8CAT, TPO

Molecular functions related to Congenital Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.1CAT, TPO

Products for genes affiliated with Congenital Rubella

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Rubella

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet