MCID: CNG033
MIFTS: 40

Congenital Syphilis malady

Infectious diseases, Neuronal diseases categories
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Summaries for Congenital Syphilis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

MalaCards: Congenital Syphilis, also known as syphilis, congenital, is related to thrombocytopenia and hepatitis. An important gene associated with Congenital Syphilis is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7). The compounds ursodeoxycholic acid and pravastatin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and brain.

Disease Ontology:8 A syphilis that results in a multisystem infection in the fetus via the placenta.

Aliases & Classifications for Congenital Syphilis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

congenital syphilis 8
syphilis, congenital 62
syphilis congenital 45


External Ids:

Disease Ontology8 DOID:9856
MeSH35 D013590
ICD9CM27 090, 090.9
NCIt40 C84649
ICD1025 A50

Related Diseases for Congenital Syphilis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to congenital syphilis

Symptoms for Congenital Syphilis

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Drugs & Therapeutics for Congenital Syphilis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Congenital Syphilis

Search NIH Clinical Center for Congenital Syphilis

Genetic Tests for Congenital Syphilis

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Anatomical Context for Congenital Syphilis

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33MalaCards
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MalaCards organs/tissues related to Congenital Syphilis:

33
Bone, Eye, Brain, Placenta, Testes, Skin, Liver, Tongue, Pituitary

Animal Models for Congenital Syphilis or affiliated genes

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Publications for Congenital Syphilis

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52PubMed
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Articles related to Congenital Syphilis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Congenital syphilis, still a reality. (23919058)
2013
2
Incidence of congenital syphilis in Brazil and its relationship with the Family Health Strategy. (22635036)
2012
3
Disseminated intravascular coagulation with intracranial haematoma in neonatal congenital syphilis. (20889622)
2011
4
Congenital syphilis, RAcunion Island, 2010. (22099109)
2011
5
Congenital syphilis: still a serious, under-diagnosed threat for children in resource-poor countries. (20490768)
2010
6
Cost-effectiveness of on-site antenatal screening to prevent congenital syphilis in rural eastern Cape Province, Republic of South Africa. (17308502)
2007
7
Managing congenital syphilis again? The more things change ... (17471033)
2007
8
Detection and follow up of infants at risk of congenital syphilis. (16790724)
2006
9
Congenital syphilis--United States, 2002. (15306757)
2004
10
The prevention and management of congenital syphilis: an overview and recommendations. (15356934)
2004
11
Survival with hypopituitarism from congenital syphilis. (11927736)
2002
12
Congenital syphilis after maternal treatment for syphilis during pregnancy. (11904625)
2002
13
Unusual presentation of congenital syphilis. (10945059)
2000
14
Haemophagocytosis in early congenital syphilis. (10412813)
1999
15
Congenital syphilis: subtle presentation of fulminant disease. (9039217)
1997
16
New approaches to syphilis control. Finding opportunities for syphilis treatment and congenital syphilis prevention in a women's correctional setting. (9101633)
1997
17
Immune abnormalities in guinea pigs with asymptomatic congenital syphilis. (9396560)
1997
18
Congenital syphilis: still a reality in 1996. (8890847)
1996
19
Diagnosis of congenital syphilis from placental examination: comparison of histopathology, Steiner stain, and polymerase chain reaction for Treponema pallidum DNA. (8617480)
1996
20
A blood-result turn-around time survey to improve congenital syphilis prevention in a rural area. (8685786)
1996
21
Congenital syphilis and STD surveillance. (7809784)
1994
22
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
23
Diagnosis of congenital syphilis by combining Treponema pallidum-specific IgM detection with immunofluorescent antigen detection for T. pallidum. (8515119)
1993
24
The diagnosis and management of maternal and congenital syphilis. (1538267)
1992
25
Radiologic case study. Congenital syphilis. (1508775)
1992
26
Characteristics of mothers of live infants with congenital syphilis in Florida, 1987-1989. (1442732)
1992
27
Congenital syphilis criteria. (1983907)
1991
28
Relative placental weight in congenital syphilis. (2326235)
1990
29
Congenital syphilis. (2274080)
1990
30
Congenital syphilis--breaking through the safety net. (2215621)
1990
31
Early and congenital syphilis. (2687743)
1989
32
Unusual bone changes and laboratory features in congenital syphilis. (2583817)
1989
33
Congenital syphilis and necrotizing funisitis. (2754789)
1989
34
Congenital syphilis in Mocambique: the diagnostic complementary role of laboratory and radiological investigations. (2485711)
1989
35
Congenital syphilis and necrotizing funisitis. (2918676)
1989
36
Leads from the MMWR. Syphilis and congenital syphilis--United States, 1985-1988. (3411729)
1988
37
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. (3276855)
1988
38
From the MMWR. Syphilis and congenital syphilis--United States, 1985-1988. (2844123)
1988
39
Congenital syphilis--a plea for prevention. (3420474)
1988
40
Congenital syphilis. Why is it still occurring? (6471297)
1984
41
Marshall syndrome: a condition resembling congenital syphilis. (7214117)
1981
42
False-positive solubility--turbidity test for sickling hemoglobin in a case of congenital syphilis. (7353299)
1980
43
Membranous glomerulonephritis in congenital syphilis. (383337)
1979
44
Congenital syphilis of the eye with lens involvement. (350202)
1978
45
Transplacental transmission of spirochetes in congenital syphilis: a new perspective. (725705)
1978
46
Value of bone roentgenograms in diagnosis. Congenital syphilis with unusual clinical presentations. (16848)
1977
47
Some aspects of congenital syphilis. (1228134)
1975
48
Congenital syphilis. (4489969)
1973
49
Glomerulopathy of congenital syphilis. (4702912)
1973
50
Nephropathy of congenital syphilis. (4270175)
1973

Variations for Congenital Syphilis

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Expression for genes affiliated with Congenital Syphilis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for genes affiliated with Congenital Syphilis

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Compounds for genes affiliated with Congenital Syphilis

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Congenital Syphilis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid45 24 1111.4CD40LG, ABCB7
2pravastatin45 51 29 24 1113.4CD40LG, ABCB7
3thyroxine45 2410.3ABCB7, CD40LG
4fibrinogen459.3CD40LG, ABCB7
5lactate459.3CD40LG, ABCB7
6creatinine459.2ABCB7, CD40LG
7aspartate459.2CD40LG, ABCB7
8heparin45 29 24 1112.1CD40LG, ABCB7
9alanine459.1CD40LG, ABCB7
10testosterone45 61 24 1112.0ABCB7, CD40LG
11glutamate458.8CD40LG, ABCB7

GO Terms for genes affiliated with Congenital Syphilis

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Products for genes affiliated with Congenital Syphilis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Syphilis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet