MCID: CNG033
MIFTS: 40

Congenital Syphilis malady

Infectious diseases category

Summaries for Congenital Syphilis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

MalaCards: Congenital Syphilis, also known as syphilis, congenital, is related to thrombocytopenia and syphilis. An important gene associated with Congenital Syphilis is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Leishmaniasis and B cell receptor signaling pathway. The compounds ursodeoxycholic acid and thyroxine have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and brain, and related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:8 A syphilis that results in a multisystem infection in the fetus via the placenta.

Aliases & Classifications for Congenital Syphilis

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

congenital syphilis 8
syphilis, congenital 60
syphilis congenital 44


External Ids:

Disease Ontology8 DOID:9856
MeSH34 D013590
NCIt39 C84649
ICD9CM27 090, 090.9
ICD1025 A50

Related Diseases for Congenital Syphilis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to congenital syphilis

Clinical Features for Congenital Syphilis

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Drugs & Therapeutics for Congenital Syphilis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Congenital Syphilis

Drug clinical trials:

Search ClinicalTrials for Congenital Syphilis

Search NIH Clinical Center for Congenital Syphilis

Search CenterWatch for Congenital Syphilis

Genetic Tests for Congenital Syphilis

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Anatomical Context for Congenital Syphilis

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32MalaCards
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MalaCards organs/tissues related to Congenital Syphilis:

32
Bone, Eye, Brain, Placenta, Testes, Skin, Liver, Tongue, Pituitary

Animal Models for Congenital Syphilis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Congenital Syphilis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0ABCB7, IKBKG, CD40LG, STIL
2MP:00053847.7ABCB7, IKBKG, CD40LG, STIL

Publications for Congenital Syphilis

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50PubMed
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Articles related to Congenital Syphilis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Preventing congenital syphilis - a regional audit of syphilis in pregnant women seen in Genitourinary Medicine services. (24285598)
2013
2
Early congenital syphilis in a premature baby. (21107603)
2011
3
Update on emerging infections: news from the Centers for Disease Control and Prevention. Congenital syphilis--United States 2003-2008. (20879161)
2010
4
Commentary. Update on emerging infections: news from the Centers for Disease Control and Prevention. Congenital syphilis--United States 2003-2008. (20728770)
2010
5
Early congenital syphilis with isolated bone involvement: a case report. (19480330)
2009
6
Managing congenital syphilis again? The more things change ... (17471033)
2007
7
Early congenital syphilis presented with exclusive bending pain of extremity: case report. (17291306)
2007
8
The need and plan for global elimination of congenital syphilis. (17592390)
2007
9
Congenital syphilis. (16641589)
2006
10
Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction. (16843116)
2006
11
Prenatal and congenital syphilis in British Columbia. (16100641)
2005
12
Congenital syphilis presenting with nephrotic syndrome and leucocytoclastic vasculitis. (15196169)
2004
13
Prevention of congenital syphilis--time for action. (15356930)
2004
14
Maternal and congenital syphilis programmes: case studies in Bolivia, Kenya and South Africa. (15356932)
2004
15
Congenital syphilis in a Nairobi maternity hospital. (15868969)
2004
16
Diagnostic tools for preventing and managing maternal and congenital syphilis: an overview. (15356937)
2004
17
Decreased congenital syphilis incidence in Haiti's rural Artibonite region following decentralized prenatal screening. (12604493)
2003
18
Congenital syphilis in an immunocompromised neonate: case report. (15018425)
2003
19
Congenital syphilis after maternal treatment for syphilis during pregnancy. (11904625)
2002
20
Congenital syphilis and fluorescent treponemal antibody test reactivity after the age of 1 year. (11460026)
2001
21
Haemophagocytosis in early congenital syphilis. (10412813)
1999
22
Congenital syphilis in a newborn: an immunopathologic study. (9950167)
1999
23
The resurgence of congenital syphilis: a cocaine-related problem. (9042134)
1997
24
Diagnosis of congenital syphilis from placental examination: comparison of histopathology, Steiner stain, and polymerase chain reaction for Treponema pallidum DNA. (8617480)
1996
25
Centers for Disease Control and Prevention guidelines for congenital syphilis. (8859252)
1996
26
Skeletal lesions in early congenital syphilis (a review of 86 cases). (7552208)
1995
27
Congenital syphilis: evaluation and management of neonates born to mothers with reactive serologic tests for syphilis. (7854881)
1994
28
Absence of lower extremity ossification centers in term infants with congenital syphilis. (8014691)
1994
29
Secular trends in New York City hospital discharge diagnoses of congenital syphilis and cocaine dependence, 1982-88. (8497564)
1993
30
Evaluation of molecular methodologies and rabbit infectivity testing for the diagnosis of congenital syphilis and neonatal central nervous system invasion by Treponema pallidum. (8418161)
1993
31
Critical illness in congenital syphilis after the newborn period. (1563201)
1992
32
Congenital syphilis. (1616961)
1992
33
Risk factors for congenital syphilis. (1715153)
1991
34
Congenital syphilis--breaking through the safety net. (2215621)
1990
35
Epidemiology of congenital syphilis. (2594224)
1989
36
Syphilis and congenital syphilis--United States, 1985-1988. (3135479)
1988
37
Congenital syphilis--a report of 3 cases. (3249970)
1988
38
Early congenital syphilis still occurs. (3707199)
1986
39
Early congenital syphilis: clinico-radiologic features in 202 patients. (4081939)
1985
40
Value of serological diagnosis in congenital syphilis. Report of nine cases. (7448581)
1980
41
Membranous glomerulonephritis in congenital syphilis. (383337)
1979
42
Congenital syphilis with syphilitic arthritis. Radiological quiz. (847214)
1977
43
Treatment of congenital syphilis. (1010784)
1976
44
The glomerulopathy of congenital syphilis. A curable immune-deposit disease. (4276729)
1974
45
Letter: Liver involvement in congenital syphilis. (4602140)
1974
46
Congenital syphilis in newborn. (4692180)
1973
47
Testing for congenital syphilis in interstitial keratitis. (4938990)
1971
48
Paroxysmal cold hemoglobinuria in treated congenital syphilis. (13123556)
1954
49
Fever in early congenital syphilis. (13196895)
1954
50
The effect of penicillin on late congenital syphilis, with special reference to the Wassermann reaction. (18101571)
1948

Genetic Variations for Congenital Syphilis

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Expression for genes affiliated with Congenital Syphilis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for genes affiliated with Congenital Syphilis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Congenital Syphilis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Congenital Syphilis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid44 11 2411.3ABCB7, CD40LG
2thyroxine44 2410.3ABCB7, CD40LG
3pravastatin44 49 28 11 2413.0ABCB7, CD40LG
4cytidine44 11 2410.9IKBKG, CD40LG

GO Terms for genes affiliated with Congenital Syphilis

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Products for genes affiliated with Congenital Syphilis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Syphilis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet