MCID: CNG033
MIFTS: 40

Congenital Syphilis

Categories: Infectious diseases, Bone diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Congenital Syphilis

MalaCards integrated aliases for Congenital Syphilis:

Name: Congenital Syphilis 12 72 55 14
Syphilis, Congenital 41 69
Mother-to-Child Transmission of Syphilis 55
Syphilis Congenital 51
Mtct of Syphilis 55

Classifications:



External Ids:

Disease Ontology 12 DOID:9856
ICD10 32 A50 A50.9
ICD9CM 34 090 090.9
MeSH 41 D013590
NCIt 46 C84649
Orphanet 55 ORPHA499009
UMLS 69 C0039131

Summaries for Congenital Syphilis

Disease Ontology : 12 A syphilis that results_in a multisystem infection in the fetus via the placenta.

MalaCards based summary : Congenital Syphilis, also known as syphilis, congenital, is related to late congenital syphilis and early congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Congenital Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Penicillin G and penicillins have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and eye.

Wikipedia : 72 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

Related Diseases for Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 late congenital syphilis 34.1 DDX41 EXTL3
2 early congenital syphilis 34.0 CD40LG MYH9
3 syphilis 31.0 CD40LG CD79A EXTL3 MYH9
4 chorioretinitis 29.5 CD40LG CD79A EXTL3
5 primary syphilis 28.8 CD40LG DDX41 EXTL3 MYH9
6 paroxysmal cold hemoglobinuria 11.2
7 selective igg deficiency disease 10.4 CD40LG CD79A
8 c1q nephropathy 10.4 CD40LG CD79A
9 meningovascular neurosyphilis 10.4 CD40LG CD79A
10 alpha chain disease 10.4 CD40LG CD79A
11 brill-zinsser disease 10.4 CD40LG CD79A
12 exudative glomerulonephritis 10.4 CD40LG CD79A
13 cork-handlers' disease 10.4 CD40LG CD79A
14 salpingo-oophoritis 10.4 CD40LG CD79A
15 ventilation pneumonitis 10.4 CD40LG CD79A
16 chronic interstitial cystitis 10.4 CD40LG CD79A
17 axillary adenitis 10.4 CD40LG CD79A
18 cryofibrinogenemia 10.4 CD40LG CD79A
19 trichostrongyloidiasis 10.4 CD40LG CD79A
20 subacute bacterial endocarditis 10.4 CD40LG CD79A
21 heterophyiasis 10.4 CD40LG CD79A
22 immunoglobulin g deficiency 10.4 CD40LG CD79A
23 orbital granuloma 10.4 CD40LG CD79A
24 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
25 hyperglobulinemic purpura 10.4 CD40LG CD79A
26 gastroduodenitis 10.4 CD40LG CD79A
27 bacterial conjunctivitis 10.4 CD40LG CD79A
28 heavy chain disease 10.4 CD40LG CD79A
29 ophthalmia neonatorum 10.4 CD40LG CD79A
30 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
31 parotid disease 10.4 CD40LG CD79A
32 cerebral arteritis 10.4 CD40LG CD79A
33 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
34 geniculate herpes zoster 10.4 CD40LG CD79A
35 erythema elevatum diutinum 10.4 CD40LG CD79A
36 sporotrichosis 10.4 CD40LG CD79A
37 fallopian tube disease 10.4 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.4 CD40LG CD79A
39 polyclonal hypergammaglobulinemia 10.4 CD40LG CD79A
40 monoclonal paraproteinemia 10.4 CD40LG CD79A
41 salpingitis 10.4 CD40LG CD79A
42 ocular toxoplasmosis 10.4 CD40LG CD79A
43 parasitic ichthyosporea infectious disease 10.4 CD40LG CD79A
44 dysgammaglobulinemia 10.4 CD40LG CD79A
45 congenital hypogammaglobulinemia 10.4 CD40LG CD79A
46 acute maxillary sinusitis 10.4 CD40LG CD79A
47 rhinosporidiosis 10.4 CD40LG CD79A
48 chronic polyneuropathy 10.4 CD40LG CD79A
49 spinocerebellar ataxia, autosomal recessive 10 10.4 CD40LG CD79A
50 cd40 ligand deficiency 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to Congenital Syphilis

Symptoms & Phenotypes for Congenital Syphilis

UMLS symptoms related to Congenital Syphilis:


syphilitic chancre

Drugs & Therapeutics for Congenital Syphilis

Drugs for Congenital Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved 61-33-6 5904
2 penicillins
3 Penicillin G Benzathine
4 Penicillin G Procaine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing Congenital Syphilis Active, not recruiting NCT02353117

Search NIH Clinical Center for Congenital Syphilis

Cochrane evidence based reviews: syphilis, congenital

Genetic Tests for Congenital Syphilis

Anatomical Context for Congenital Syphilis

MalaCards organs/tissues related to Congenital Syphilis:

38
Bone, Liver, Eye, Brain, Placenta, Spleen, Testes

Publications for Congenital Syphilis

Articles related to Congenital Syphilis:

(show top 50) (show all 605)
# Title Authors Year
1
Presence of dental signs of congenital syphilis in pre-modern specimens. ( 29102860 )
2018
2
Analysis of cases of gestational and congenital syphilis between 2008 and 2010 in Fortaleza, State of CearA!, Brazil. ( 29412414 )
2018
3
A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities. ( 29314211 )
2018
4
Congenital syphilis in 2 children in a Bolivian prison. ( 29364335 )
2017
5
Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. ( 28942420 )
2017
6
Congenital Syphilis of Bone: A Potential Mimicker of Childhood Histiocytoses. ( 28614210 )
2017
7
Congenital syphilis in neonates with nonreactive nontreponemal test results. ( 28682315 )
2017
8
Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil. ( 29166489 )
2017
9
Dental Traits of Congenital Syphilis Revisited in Dental Outpatient Department (OPD). ( 28342059 )
2017
10
Educational intervention in Primary Care for the prevention of congenital syphilis. ( 28146181 )
2017
11
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. ( 29103618 )
2017
12
Early Congenital Syphilis: Recognising Symptoms of an Increasingly Prevalent Disease. ( 28821219 )
2017
13
Congenital Syphilis: Time for a National Prevention Program. ( 28703732 )
2017
14
Syphilis in Pregnancy and Congenital Syphilis: Reality in a Portuguese Central University Hospital. ( 28609805 )
2017
15
Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis. ( 29233254 )
2017
16
Congenital syphilis with bone lesion: case report. ( 29234661 )
2017
17
Barriers and facilitators to the implementation of antenatal syphilis screening and treatment for the prevention of congenital syphilis in the Democratic Republic of Congo and Zambia: results of qualitative formative research. ( 28807019 )
2017
18
Congenital Syphilis Presenting with Only Nephrotic Syndrome: Reemergence of a Forgotten Disease. ( 28665076 )
2017
19
Sensitivity of nPCR for four types of membrane protein DNA and of two pairs of primers for Tpp47 DNA of Treponema pallidum in whole blood of congenital syphilis newborns. ( 28889773 )
2017
20
Congenital syphilis in England and amendments to the BASHH guideline for management of affected infants. ( 29027897 )
2017
21
Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013-2014. ( 28703731 )
2017
22
Diagnostic and Therapeutic Knowledge and Practices in the Management of Congenital Syphilis by Pediatricians in Public Maternity Hospitals in Brazil. ( 28735562 )
2017
23
Late-onset congenital syphilis with unusual brain abnormalities. ( 28977151 )
2017
24
Pseudoparalysis of Parrot: A Diagnostic Aid in Congenital Syphilis. ( 28918883 )
2017
25
Congenital Syphilis Masquerading as Leukemia. ( 28845335 )
2017
26
Risk of Congenital Syphilis (CS) Following Treatment of Maternal Syphilis: Results of a CS Control Program in China. ( 28444157 )
2017
27
Congenital syphilis. ( 28626975 )
2017
28
Congenital Syphilis: The Great Pretender Strikes Back. A Case Report. ( 29084433 )
2017
29
Syphilis in pregnancy and congenital syphilis in Palmas, Tocantins State, Brazil, 2007-2014. ( 28492767 )
2017
30
Characterization and six-month follow-up on a cohort of newborns with congenital syphilis. ( 27622443 )
2016
31
Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La RAcunion, 2008 to 2014. ( 27711044 )
2016
32
Maternal and congenital syphilis, underreported and difficult to control. ( 27167649 )
2016
33
Infectious and congenital syphilis notifications associated with an ongoing outbreak in northern Australia. ( 27080030 )
2016
34
The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015. ( 26931054 )
2016
35
"The sins of the fathers will be visited upon the children": Congenital syphilis and leg braces pictorial depiction in eighteenth century Britain. ( 27421914 )
2016
36
Dental Stigmata of Congenital Syphilis: A Historic Review With Present Day Relevance. ( 26897633 )
2016
37
Eliminating congenital syphilis-lessons learnt in the United Kingdom should inform global strategy. ( 27102071 )
2016
38
Early Postnatal Diagnosis of Congenital Syphilis: Contribution of a Comparative Western Blot Method. ( 26961856 )
2016
39
Underreporting of Congenital Syphilis as a Cause of Fetal and Infant Deaths in Northeastern Brazil. ( 27941983 )
2016
40
A Case Report and Review of Early Symptomatic Congenital Syphilis Clinical Variations. ( 26976805 )
2016
41
Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. ( 27443780 )
2016
42
Skin rash: a manifestation of early congenital syphilis. ( 27268292 )
2016
43
Congenital syphilis in the era of decreasing seroprevalence. ( 26776135 )
2016
44
Cuba Validated as the First Country to Eliminate Mother-to-Child Transmission of Human Immunodeficiency Virus and Congenital Syphilis: Lessons Learned from the Implementation of the Global Validation Methodology. ( 27835624 )
2016
45
In time: the persistence of congenital syphilis in Brazil - More progress needed! ( 27521453 )
2016
46
Diagnosing congenital syphilis using Hutchinson's method: Differentiating between syphilitic, mercurial, and syphilitic-mercurial dental defects. ( 26696588 )
2016
47
Infant Deaths Due To Herpes Simplex Virus, Congenital Syphilis, and HIV in New York City. ( 26933212 )
2016
48
Syphilis in Pregnancy and Congenital Syphilis: Why Can We not yet Face This Problem? ( 27756083 )
2016
49
The Cuban Experience in the Elimination of Mother-to-Child Transmission of Congenital Syphilis. ( 27715301 )
2016
50
Wimberger Sign in Congenital Syphilis. ( 26427966 )
2015

Variations for Congenital Syphilis

Expression for Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for Congenital Syphilis

Pathways related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Congenital Syphilis

Biological processes related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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