MCID: CNG033
MIFTS: 34

Congenital Syphilis malady

Infectious category

Summaries for Congenital Syphilis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

MalaCards: Congenital Syphilis, also known as syphilis, congenital, is related to thrombocytopenia and syphilis. An important gene associated with Congenital Syphilis is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Leishmaniasis and B cell receptor signaling pathway. The compounds ursodeoxycholic acid and thyroxine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:8 A syphilis that results in a multisystem infection in the fetus via the placenta.

Aliases & Classifications for Congenital Syphilis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

congenital syphilis 8
syphilis, congenital 61
syphilis congenital 45


External Ids:

Disease Ontology8 DOID:9856
MeSH35 D013590
NCIt40 C84649
ICD9CM27 090, 090.9
ICD1025 A50

Related Diseases for Congenital Syphilis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to congenital syphilis

Clinical Features for Congenital Syphilis

Drugs & Therapeutics for Congenital Syphilis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Congenital Syphilis

Drug clinical trials:

Search ClinicalTrials for Congenital Syphilis

Search NIH Clinical Center for Congenital Syphilis

Search CenterWatch for Congenital Syphilis

Genetic Tests for Congenital Syphilis

Anatomical Context for Congenital Syphilis

Animal Models for Congenital Syphilis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Congenital Syphilis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0ABCB7, IKBKG, CD40LG, STIL
2MP:00053847.7ABCB7, IKBKG, CD40LG, STIL

Publications for Congenital Syphilis

Sources:
51PubMed
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Articles related to Congenital Syphilis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Early Congenital Syphilis Presenting with Vesicobullous Eruptions Beyond Palmoplantar Regions. (24037177)
2013
2
Curse on two generations: a history of congenital syphilis. (23485862)
2013
3
Identifying unreported and undiagnosed cases of congenital syphilis in Arizona using live birth and fetal death registries. (20023596)
2010
4
One-stop service for antenatal syphilis screening and prevention of congenital syphilis in Ulaanbaatar, Mongolia: a cluster randomized trial. (19773681)
2009
5
Opportunities for the prevention of congenital syphilis in Maricopa County, Arizona. (18192931)
2008
6
Missed opportunities for congenital syphilis and HIV perinatal transmission prevention. (18833384)
2008
7
Recognizing and reducing the global burden of congenital syphilis: the time is now. (17592386)
2007
8
Congenital syphilis, still a reality in 21st century: a case report. (17877837)
2007
9
Resurgence of early congenital syphilis in Alberta. (17606936)
2007
10
Congenital syphilis in China. (17416254)
2007
11
Epidemiology of syphilis in pregnant women and congenital syphilis in Belarus. (16850097)
2006
12
Congenital syphilis--United States, 2002. (15306757)
2004
13
Economic and programmatic aspects of congenital syphilis prevention. (15356931)
2004
14
Keratopathy from congenital syphilis. (12131041)
2002
15
Placental histopathology of congenital syphilis. (12100814)
2002
16
Missed opportunities for congenital syphilis prevention in an urban southeastern hospital. (11234792)
2001
17
Congenital syphilis after treatment of maternal syphilis with a penicillin regimen exceeding CDC guidelines. (9785110)
1998
18
Congenital syphilis in newborn infants. (9790623)
1998
19
New approaches to syphilis control. Finding opportunities for syphilis treatment and congenital syphilis prevention in a women's correctional setting. (9101633)
1997
20
The hospital cost of congenital syphilis. (9152285)
1997
21
Congenital syphilis associated with hyperlipoproteinemia. (9192419)
1997
22
Congenital syphilis: still a reality in 1996. (8890847)
1996
23
Congenital syphilis mimicking child abuse. (8545191)
1995
24
Evaluation of congenital syphilis surveillance system--New Jersey, 1993. (7885315)
1995
25
Congenital syphilis surveillance in upstate New York, 1989-1992: implications for prevention and clinical management. (7876630)
1995
26
Congenital syphilis: a reappraisal. (8288353)
1993
27
Comparison of maternal sera, cord blood, and neonatal sera for detecting presumptive congenital syphilis: relationship with maternal treatment. (8416511)
1993
28
Congenital syphilis: clinical manifestations in premature infants. (8052814)
1993
29
Congenital syphilis--now a notifiable disease. (1570571)
1992
30
Congenital syphilis criteria. (1983907)
1991
31
The rising incidence of congenital syphilis: back to the future. (2234612)
1990
32
Congenital syphilis: reporting and reality. (2305902)
1990
33
Early and congenital syphilis. (2687743)
1989
34
Congenital syphilis in Mocambique: the diagnostic complementary role of laboratory and radiological investigations. (2485711)
1989
35
Congenital syphilis and necrotizing funisitis. (2918676)
1989
36
The treatment of congenital syphilis with penicillin. (2799599)
1989
37
Congenital syphilis--a plea for prevention. (3420474)
1988
38
Congenital syphilis in the newborn. (3202651)
1988
39
Sarcoid reactions in a patient with congenital syphilis. (3049736)
1988
40
Review of congenital syphilis. (6710286)
1984
41
The stigmata of late congenital syphilis: an analysis of 100 patients. (6648746)
1983
42
Congenital syphilis in Lusaka--II. Incidence at birth and potential risk among hospital deliveries. (7173066)
1982
43
Congenital syphilis: an unusual presentation. (7403512)
1980
44
Cell-mediated immunological reactivity in neonates and infants with congenital syphilis. (342155)
1977
45
Questionnaire survey of reported early congenital syphilis: problems in diagnosis, prevention, and treatment. (594857)
1977
46
Bone lesions in early congenital syphilis. (1251290)
1976
47
A reappraisal of the value of the IgM fluorescent treponemal antibody absorption test in the diagnosis of congenital syphilis. (1097616)
1975
48
Nephrotic syndrome of congenital syphilis. Biopsy studies in four cases. (4274228)
1974
49
Late congenital syphilis untreated until adulthood. (4714656)
1973
50
Congenital Syphilis showing widespread Periostitis of the Long Bones. (19973989)
1909

Genetic Variations for Congenital Syphilis

Expression for genes affiliated with Congenital Syphilis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for genes affiliated with Congenital Syphilis

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
See all sources

Compounds for genes affiliated with Congenital Syphilis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Congenital Syphilis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid45 11 2411.3ABCB7, CD40LG
2thyroxine45 2410.3ABCB7, CD40LG
3pravastatin45 50 29 11 2413.0ABCB7, CD40LG
4cytidine45 11 2410.9IKBKG, CD40LG

GO Terms for genes affiliated with Congenital Syphilis

Products for genes affiliated with Congenital Syphilis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Syphilis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet