MCID: CNG033
MIFTS: 40

Congenital Syphilis malady

Infectious diseases category

Summaries for Congenital Syphilis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

MalaCards: Congenital Syphilis, also known as syphilis, congenital, is related to thrombocytopenia and syphilis. An important gene associated with Congenital Syphilis is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Leishmaniasis and B cell receptor signaling pathway. The compounds ursodeoxycholic acid and thyroxine have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and brain, and related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:8 A syphilis that results in a multisystem infection in the fetus via the placenta.

Aliases & Classifications for Congenital Syphilis

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

congenital syphilis 8
syphilis, congenital 60
syphilis congenital 44


External Ids:

Disease Ontology8 DOID:9856
MeSH34 D013590
NCIt39 C84649
ICD9CM27 090, 090.9
ICD1025 A50

Related Diseases for Congenital Syphilis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to congenital syphilis

Clinical Features for Congenital Syphilis

About this section

Drugs & Therapeutics for Congenital Syphilis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Congenital Syphilis

Drug clinical trials:

Search ClinicalTrials for Congenital Syphilis

Search NIH Clinical Center for Congenital Syphilis

Search CenterWatch for Congenital Syphilis

Genetic Tests for Congenital Syphilis

About this section

Anatomical Context for Congenital Syphilis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Congenital Syphilis:

32
Bone, Eye, Brain, Placenta, Testes, Skin, Liver, Tongue, Pituitary

Animal Models for Congenital Syphilis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Congenital Syphilis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0ABCB7, IKBKG, CD40LG, STIL
2MP:00053847.7ABCB7, IKBKG, CD40LG, STIL

Publications for Congenital Syphilis

About this section
Sources:
50PubMed
See all sources

Articles related to Congenital Syphilis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Missed opportunities for preventing congenital syphilis infection. (23584807)
2013
2
Hospitalization cost of congenital syphilis diagnosis from insurance claims data in the United States. (23407468)
2013
3
Seroreversion of treponemal tests in infants meeting canadian surveillance criteria for confirmed early congenital syphilis. (22976052)
2013
4
Epidemiological surveillance of congenital syphilis in Spain, 2000-2010. (22572752)
2012
5
Congenital syphilis in Italy: a multicentre study. (20870907)
2012
6
Disseminated intravascular coagulation with intracranial haematoma in neonatal congenital syphilis. (20889622)
2011
7
A case of congenital syphilis with Hutchinson's triad. (21799574)
2011
8
Higoumenakis' sign in the diagnosis of congenital syphilis in anthropological specimens. (21498006)
2011
9
A risk model for congenital syphilis in infants born to mothers with syphilis treated in gestation: a prospective cohort study. (20460262)
2010
10
Congenital syphilis: an economic evaluation of a prevention program in China. (19734825)
2010
11
Successful outcome with intrauterine transfusion in non-immune hydrops fetalis secondary to congenital syphilis. (21050519)
2010
12
A road map for the global elimination of congenital syphilis. (20706693)
2010
13
Maternal and congenital syphilis in rural Haiti. (20058828)
2009
14
Occurrence of congenital syphilis after maternal treatment with azithromycin during pregnancy. (17589329)
2007
15
Congenital syphilis: a persisting sentinel public health event. (16794558)
2006
16
The girl from the church of the sacrament: a case of congenital syphilis in XVIII century Lisbon. (17308818)
2006
17
Phthisis bulbi caused by late congenital syphilis untreated until adulthood. (15767072)
2005
18
Maternal and congenital syphilis: case definitions. (16206407)
2005
19
The prevention and management of congenital syphilis: an overview and recommendations. (15356934)
2004
20
Congenital syphilis: identification of two distinct profiles of maternal characteristics associated with risk. (14695956)
2004
21
Early congenital syphilis--a continuing problem in Malaysia. (7565181)
1995
22
Maternal and congenital syphilis in Zambia. (12290564)
1995
23
The cost of a preventable disease: estimated U.S. national medical expenditures for congenital syphilis, 1990. (7638327)
1995
24
Congenital syphilis: the diagnostic value of the rheumatoid factor in symptomatic patients. (7506885)
1993
25
Pathology of congenital syphilis in rabbits. (8406873)
1993
26
Congenital syphilis as a notifiable disease. (8191322)
1993
27
Radiologic case study. Congenital syphilis. (1508775)
1992
28
Serological tests in cerebrospinal fluid for congenital syphilis in central Africa. (1280042)
1992
29
Annular lesions in congenital syphilis. (1607199)
1992
30
IgM antibody to Treponema pallidum in cerebrospinal fluid of infants with congenital syphilis. (1415044)
1992
31
Long-bone radiographic abnormalities as a sign of active congenital syphilis in asymptomatic newborns. (1945608)
1991
32
Pulmonary changes in congenital syphilis. (1749670)
1991
33
Immune studies in infants with congenital syphilis. (2143709)
1990
34
Congenital syphilis--who is at risk? A prevalence study at Baragwanath Hospital, Johannesburg, 1985-1986. (2788310)
1989
35
Leads from the MMWR. Syphilis and congenital syphilis--United States, 1985-1988. (3411729)
1988
36
Guidelines for the prevention and control of congenital syphilis. (3123914)
1988
37
Prevention of congenital syphilis. (3167294)
1988
38
Congenital syphilis. A case report. (6848526)
1983
39
Congenital syphilis in Lusaka--III. Incidence in the neonatal intensive-care unit. (7173075)
1982
40
Marshall syndrome: a condition resembling congenital syphilis. (7214117)
1981
41
Congenital syphilis in the fetus and neonate. (7322824)
1981
42
The laboratory diagnosis of congenital syphilis: a review. (382852)
1979
43
Unusual bone involvement in congenital syphilis mimicking the battered child syndrome. (733400)
1978
44
Letter: Behavior of the complement system in the nephropathy of congenital syphilis. (1249704)
1976
45
Acquired syphilis in three patients with congenital syphilis. (4595222)
1974
46
A child with nephrotic syndrome and late congenital syphilis. (Case report). (4456247)
1974
47
Glomerulopathy of congenital syphilis. (4702912)
1973
48
The re-emergence of early congenital syphilis. (4765579)
1973
49
Penicillin treatment for early congenital syphilis. (14350886)
1955
50
The Jarisch-Herxheimer reaction in early congenital syphilis; a study of 93 patients treated with penicillin alone. (18121295)
1949

Genetic Variations for Congenital Syphilis

About this section

Expression for genes affiliated with Congenital Syphilis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for genes affiliated with Congenital Syphilis

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
See all sources

Compounds for genes affiliated with Congenital Syphilis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Congenital Syphilis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid44 11 2411.3ABCB7, CD40LG
2thyroxine44 2410.3ABCB7, CD40LG
3pravastatin44 49 28 11 2413.0ABCB7, CD40LG
4cytidine44 11 2410.9IKBKG, CD40LG

GO Terms for genes affiliated with Congenital Syphilis

About this section

Products for genes affiliated with Congenital Syphilis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Syphilis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet