MCID: CNG033
MIFTS: 37

Congenital Syphilis

Categories: Infectious diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Congenital Syphilis

MalaCards integrated aliases for Congenital Syphilis:

Name: Congenital Syphilis 12 14
Syphilis, Congenital 42 69
Syphilis Congenital 52

Classifications:



External Ids:

Disease Ontology 12 DOID:9856
ICD10 33 A50 A50.9
ICD9CM 35 090 090.9
MeSH 42 D013590
NCIt 47 C84649
UMLS 69 C0039131

Summaries for Congenital Syphilis

Disease Ontology : 12 A syphilis that results_in a multisystem infection in the fetus via the placenta.

MalaCards based summary : Congenital Syphilis, also known as syphilis, congenital, is related to early congenital syphilis and late congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Congenital Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Heptavalent Pneumococcal Conjugate Vaccine and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and eye.

Wikipedia : 72 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

Related Diseases for Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
id Related Disease Score Top Affiliating Genes
1 early congenital syphilis 34.0 CD40LG CD79A
2 late congenital syphilis 12.3
3 paroxysmal cold hemoglobinuria 11.1
4 syphilis 10.9
5 alcoholic neuropathy 10.6 CD40LG CD79A
6 calloso-genital dysplasia 10.6 CD40LG CD79A
7 variola major 10.6 CD40LG CD79A
8 mu chain disease 10.6 CD40LG CD79A
9 rabies 10.6 CD40LG CD79A
10 familial retinoblastoma 10.6 CD40LG CD79A
11 anti-basement membrane glomerulonephritis 10.6 CD40LG CD79A
12 microinvasive cervical squamous cell carcinoma 10.6 CD40LG CD79A
13 fetal erythroblastosis 10.6 CD40LG CD79A
14 spinal canal and spinal cord meningioma 10.6 CD40LG CD79A
15 trichostrongyloidiasis 10.6 CD40LG CD79A
16 retinal microaneurysm 10.6 CD40LG CD79A
17 heart septal defect 10.6 CD40LG CD79A
18 cryptorchidism arachnodactyly mental retardation 10.5 CD40LG CD79A
19 acute kidney tubular necrosis 10.5 CD40LG CD79A
20 secretory meningioma 10.5 CD40LG CD79A
21 hodgkin's lymphoma, nodular sclerosis 10.5 CD40LG CD79A
22 imperforate oropharynx-costo vetebral anomalies 10.5 CD40LG CD79A
23 malignant otitis externa 10.5 CD40LG CD79A
24 transient hypogammaglobulinemia 10.5 CD40LG CD79A
25 benign epilepsy with centrotemporal spikes 10.5 CD40LG CD79A
26 tongue cancer 10.5 CD40LG CD79A
27 hydrops of gallbladder 10.5 CD40LG CD79A
28 gamma heavy chain disease 10.5 CD40LG CD79A
29 diabetic angiopathy 10.5 CD40LG CD79A
30 rosacea conjunctivitis 10.5 CD40LG CD79A
31 viral meningitis 10.5 CD40LG CD79A
32 heart fibrosarcoma 10.5 CD40LG CD79A
33 kidney carcinoma in situ 10.5 CD40LG CD79A
34 cardiac tuberculosis 10.5 CD40LG CD79A
35 dumping syndrome 10.5 CD40LG CD79A
36 leiomyosarcoma 10.5 CD40LG CD79A
37 periarthritis 10.5 CD40LG CD79A
38 generalized atherosclerosis 10.5 CD40LG CD79A
39 colonic benign neoplasm 10.5 CD40LG CD79A
40 pancreatic vasoactive intestinal peptide producing tumor 10.5 CD40LG CD79A
41 oculo-cerebral dysplasia 10.5 CD40LG CD79A
42 aniseikonia 10.5 CD40LG CD79A
43 gestational diabetes 10.5 CD40LG CD79A
44 polyneuropathy due to drug 10.5 CD40LG CD79A
45 chronic mucocutaneous candidiasis 10.5 CD40LG CD79A
46 cutaneous ganglioneuroma 10.5 CD40LG CD79A
47 acute hemorrhagic encephalitis 10.5 CD40LG CD79A
48 mental retardation, autosomal dominant 19 10.5 CD40LG CD79A
49 adie pupil 10.5 CD40LG CD79A
50 immunoglobulin alpha deficiency 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to Congenital Syphilis

Symptoms & Phenotypes for Congenital Syphilis

UMLS symptoms related to Congenital Syphilis:


syphilitic chancre

Drugs & Therapeutics for Congenital Syphilis

Drugs for Congenital Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
2 mometasone furoate Phase 3 83919-23-7
3 Vaccines Phase 3
4
Penicillin G Approved, Vet_approved 61-33-6 5904
5 Penicillin G Benzathine
6 Penicillin G Procaine
7 penicillins

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
2 Preventing Congenital Syphilis Recruiting NCT02353117

Search NIH Clinical Center for Congenital Syphilis

Cochrane evidence based reviews: syphilis, congenital

Genetic Tests for Congenital Syphilis

Anatomical Context for Congenital Syphilis

MalaCards organs/tissues related to Congenital Syphilis:

39
Bone, Liver, Eye, Placenta, Brain, Spleen, Testes

Publications for Congenital Syphilis

Articles related to Congenital Syphilis:

(show top 50) (show all 593)
id Title Authors Year
1
Syphilis in Pregnancy and Congenital Syphilis: Reality in a Portuguese Central University Hospital. ( 28609805 )
2017
2
Congenital Syphilis: Time for a National Prevention Program. ( 28703732 )
2017
3
Diagnostic and Therapeutic Knowledge and Practices in the Management of Congenital Syphilis by Pediatricians in Public Maternity Hospitals in Brazil. ( 28735562 )
2017
4
Congenital Syphilis of Bone: A Potential Mimicker of Childhood Histiocytoses. ( 28614210 )
2017
5
Congenital syphilis. ( 28626975 )
2017
6
Congenital Syphilis Masquerading as Leukemia. ( 28845335 )
2017
7
Sensitivity of nPCR for four types of membrane protein DNA and of two pairs of primers for Tpp47 DNA of Treponema pallidum in whole blood of congenital syphilis newborns. ( 28889773 )
2017
8
Congenital syphilis in neonates with nonreactive nontreponemal test results. ( 28682315 )
2017
9
Pseudoparalysis of Parrot: A Diagnostic Aid in Congenital Syphilis. ( 28918883 )
2017
10
Dental Traits of Congenital Syphilis Revisited in Dental Outpatient Department (OPD). ( 28342059 )
2017
11
Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. ( 28942420 )
2017
12
Barriers and facilitators to the implementation of antenatal syphilis screening and treatment for the prevention of congenital syphilis in the Democratic Republic of Congo and Zambia: results of qualitative formative research. ( 28807019 )
2017
13
Risk of Congenital Syphilis (CS) Following Treatment of Maternal Syphilis: Results of a CS Control Program in China. ( 28444157 )
2017
14
Congenital Syphilis Presenting with Only Nephrotic Syndrome: Reemergence of a Forgotten Disease. ( 28665076 )
2017
15
Early Congenital Syphilis: Recognising Symptoms of an Increasingly Prevalent Disease. ( 28821219 )
2017
16
Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013-2014. ( 28703731 )
2017
17
Syphilis in pregnancy and congenital syphilis in Palmas, Tocantins State, Brazil, 2007-2014. ( 28492767 )
2017
18
Educational intervention in Primary Care for the prevention of congenital syphilis. ( 28146181 )
2017
19
Characterization and six-month follow-up on a cohort of newborns with congenital syphilis. ( 27622443 )
2016
20
Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. ( 27443780 )
2016
21
Diagnosing congenital syphilis using Hutchinson's method: Differentiating between syphilitic, mercurial, and syphilitic-mercurial dental defects. ( 26696588 )
2016
22
Eliminating congenital syphilis-lessons learnt in the United Kingdom should inform global strategy. ( 27102071 )
2016
23
The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015. ( 26931054 )
2016
24
A Case Report and Review of Early Symptomatic Congenital Syphilis Clinical Variations. ( 26976805 )
2016
25
Syphilis in Pregnancy and Congenital Syphilis: Why Can We not yet Face This Problem? ( 27756083 )
2016
26
Cuba Validated as the First Country to Eliminate Mother-to-Child Transmission of Human Immunodeficiency Virus and Congenital Syphilis: Lessons Learned from the Implementation of the Global Validation Methodology. ( 27835624 )
2016
27
Infectious and congenital syphilis notifications associated with an ongoing outbreak in northern Australia. ( 27080030 )
2016
28
Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La RAcunion, 2008 to 2014. ( 27711044 )
2016
29
Dental Stigmata of Congenital Syphilis: A Historic Review With Present Day Relevance. ( 26897633 )
2016
30
Underreporting of Congenital Syphilis as a Cause of Fetal and Infant Deaths in Northeastern Brazil. ( 27941983 )
2016
31
In time: the persistence of congenital syphilis in Brazil - More progress needed! ( 27521453 )
2016
32
Infant Deaths Due To Herpes Simplex Virus, Congenital Syphilis, and HIV in New York City. ( 26933212 )
2016
33
The Cuban Experience in the Elimination of Mother-to-Child Transmission of Congenital Syphilis. ( 27715301 )
2016
34
Early Postnatal Diagnosis of Congenital Syphilis: Contribution of a Comparative Western Blot Method. ( 26961856 )
2016
35
"The sins of the fathers will be visited upon the children": Congenital syphilis and leg braces pictorial depiction in eighteenth century Britain. ( 27421914 )
2016
36
Congenital syphilis in the era of decreasing seroprevalence. ( 26776135 )
2016
37
Skin rash: a manifestation of early congenital syphilis. ( 27268292 )
2016
38
Maternal and congenital syphilis, underreported and difficult to control. ( 27167649 )
2016
39
A tryst with a dysmorphic parturient with congenital syphilis. ( 25838595 )
2015
40
A review of the guidelines for the evaluation and treatment of congenital syphilis. ( 25996197 )
2015
41
Congenital Syphilis: Trends in Mortality and Morbidity in the United States, 1999-2013. ( 26470826 )
2015
42
Dental stigmata and enamel thickness in a probable case of congenital syphilis from XVI century Croatia. ( 26263543 )
2015
43
Increase in Incidence of Congenital Syphilis - United States, 2012-2014. ( 26562206 )
2015
44
Prenatal diagnosis of congenital syphilis presenting with transient pleural effusion in the fetus: a case report and rising incidence of congenital syphilis in South Korea. ( 26753496 )
2015
45
A probable case of congenital syphilis from pre-Columbian Austria. ( 26482430 )
2015
46
Over reporting of congenital syphilis in Guangzhou, China. ( 25587890 )
2015
47
31-Week Premature Male with Congenital Syphilis. ( 26689031 )
2015
48
Republication: Two Premature Neonates of Congenital Syphilis with Severe Clinical Manifestations. ( 26543391 )
2015
49
Canadian Public Health Laboratory Network laboratory guidelines for congenital syphilis and syphilis screening in pregnant women in Canada. ( 25798162 )
2015
50
Congenital syphilis: Marching toward elimination. ( 26392646 )
2015

Variations for Congenital Syphilis

Expression for Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for Congenital Syphilis

Pathways related to Congenital Syphilis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Congenital Syphilis

Biological processes related to Congenital Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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