MCID: CNG033
MIFTS: 39

Congenital Syphilis malady

Categories: Infectious diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Congenital Syphilis

Aliases & Descriptions for Congenital Syphilis:

Name: Congenital Syphilis 12 14
Syphilis, Congenital 42 69
Syphilis Congenital 52

Classifications:



External Ids:

Disease Ontology 12 DOID:9856
ICD10 33 A50 A50.9
ICD9CM 35 090 090.9
MeSH 42 D013590
NCIt 47 C84649
UMLS 69 C0039131

Summaries for Congenital Syphilis

Disease Ontology : 12 A syphilis that results_in a multisystem infection in the fetus via the placenta.

MalaCards based summary : Congenital Syphilis, also known as syphilis, congenital, is related to syphilis and late congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Congenital Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs chloroquine and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and brain.

Wikipedia : 71 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

Related Diseases for Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
id Related Disease Score Top Affiliating Genes
1 syphilis 31.4 CD40LG CD79A EXTL3
2 late congenital syphilis 12.3
3 early congenital syphilis 12.2
4 alcoholic neuropathy 10.2 CD40LG CD79A
5 camptodactyly vertebral fusion 10.2 CD40LG CD79A
6 spinal polio 10.2 CD40LG CD79A
7 rabies 10.2 CD40LG CD79A
8 unilateral retinoblastoma 10.2 CD40LG CD79A
9 mesangial proliferative glomerulonephritis 10.2 CD40LG CD79A
10 delta chain disease 10.2 CD40LG CD79A
11 discitis 10.2 CD40LG CD79A
12 spinal canal and spinal cord meningioma 10.2 CD40LG CD79A
13 trichostrongyloidiasis 10.2 CD40LG CD79A
14 colloid adenoma 10.2 CD40LG CD79A
15 heart septal defect 10.2 CD40LG CD79A
16 cutaneous polyarteritis nodosa 10.2 CD40LG CD79A
17 retinal microaneurysm 10.2 CD40LG CD79A
18 pediatric meningioma 10.2 CD40LG CD79A
19 tonsil cancer 10.2 CD40LG CD79A
20 indomethacin antenatal infection 10.2 CD40LG CD79A
21 postcricoid region cancer 10.2 CD40LG CD79A
22 beach ear 10.2 CD40LG CD79A
23 acute kidney tubular necrosis 10.2 CD40LG CD79A
24 atheroembolism of kidney 10.2 CD40LG CD79A
25 partial sensory epilepsy 10.2 CD40LG CD79A
26 ritscher-schinzel syndrome 1 10.2 CD40LG CD79A
27 diabetic angiopathy 10.2 CD40LG CD79A
28 endocarditis 10.2 CD40LG CD79A
29 dumping syndrome 10.2 CD40LG CD79A
30 striatonigral degeneration 10.2 CD40LG CD79A
31 ciliary body spindle cell melanoma 10.2 CD40LG CD79A
32 purulent endophthalmitis 10.2 CD40LG CD79A
33 mu chain disease 10.2 CD40LG CD79A
34 generalized atherosclerosis 10.2 CD40LG CD79A
35 bursitis 10.2 CD40LG CD79A
36 homocystinuria 10.2 CD40LG CD79A
37 mental retardation, autosomal dominant 19 10.2 CD40LG CD79A
38 hemangioma of orbit 10.2 CD40LG CD79A
39 leiomyosarcoma 10.2 CD40LG CD79A
40 immunoglobulin beta deficiency 10.2 CD40LG CD79A
41 gestational diabetes 10.2 CD40LG CD79A
42 odontogenic myxoma 10.2 CD40LG CD79A
43 chronic mucocutaneous candidiasis 10.2 CD40LG CD79A
44 alkhurma hemorrhagic fever 10.2 CD40LG CD79A
45 pedophilia 10.2 CD40LG CD79A
46 polyneuropathy due to drug 10.2 CD40LG CD79A
47 colonic benign neoplasm 10.2 CD40LG CD79A
48 cutaneous ganglioneuroma 10.2 CD40LG CD79A
49 ovarian serous cystadenocarcinoma 10.2 CD40LG CD79A
50 coronary artery dissection, spontaneous 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to Congenital Syphilis

Symptoms & Phenotypes for Congenital Syphilis

UMLS symptoms related to Congenital Syphilis:


syphilitic chancre

Drugs & Therapeutics for Congenital Syphilis

Drugs for Congenital Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
2
Azithromycin Approved Phase 3 83905-01-5 55185 53477736 447043
3
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
4
Sulfadoxine Approved Phase 3 2447-57-6 17134
5
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7 mometasone furoate Phase 3 83919-23-7
8 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
9 Vaccines Phase 3
10 Chloroquine diphosphate Phase 3 50-63-5
11 Analgesics Phase 3
12 Folic Acid Antagonists Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Vitamin B Complex Phase 3
16 Anthelmintics Phase 3
17 Anti-Infective Agents Phase 3
18 Fanasil, pyrimethamine drug combination Phase 3
19 Anti-Inflammatory Agents Phase 3
20 Antimalarials Phase 3
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Renal Agents Phase 3
23 Antirheumatic Agents Phase 3
24 Antiparasitic Agents Phase 3
25 Antiprotozoal Agents Phase 3
26 Folate Nutraceutical Phase 3
27 Vitamin B9 Nutraceutical Phase 3
28
Penicillin G Approved, Vet_approved 61-33-6 5904
29 penicillins
30 Penicillin G Benzathine
31 Penicillin G Procaine

Interventional clinical trials:


id Name Status NCT ID Phase
1 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
2 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3
3 Preventing Congenital Syphilis Recruiting NCT02353117

Search NIH Clinical Center for Congenital Syphilis

Cochrane evidence based reviews: syphilis, congenital

Genetic Tests for Congenital Syphilis

Anatomical Context for Congenital Syphilis

MalaCards organs/tissues related to Congenital Syphilis:

39
Bone, Eye, Brain, Placenta, Testes, Skin, Liver

Publications for Congenital Syphilis

Articles related to Congenital Syphilis:

(show top 50) (show all 575)
id Title Authors Year
1
Infectious and congenital syphilis notifications associated with an ongoing outbreak in northern Australia. ( 27080030 )
2016
2
Infant Deaths Due To Herpes Simplex Virus, Congenital Syphilis, and HIV in New York City. ( 26933212 )
2016
3
Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La RAcunion, 2008 to 2014. ( 27711044 )
2016
4
Cuba Validated as the First Country to Eliminate Mother-to-Child Transmission of Human Immunodeficiency Virus and Congenital Syphilis: Lessons Learned from the Implementation of the Global Validation Methodology. ( 27835624 )
2016
5
Syphilis in Pregnancy and Congenital Syphilis: Why Can We not yet Face This Problem? ( 27756083 )
2016
6
"The sins of the fathers will be visited upon the children": Congenital syphilis and leg braces pictorial depiction in eighteenth century Britain. ( 27421914 )
2016
7
Characterization and six-month follow-up on a cohort of newborns with congenital syphilis. ( 27622443 )
2016
8
Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. ( 27443780 )
2016
9
Skin rash: a manifestation of early congenital syphilis. ( 27268292 )
2016
10
The Cuban Experience in the Elimination of Mother-to-Child Transmission of Congenital Syphilis. ( 27715301 )
2016
11
In time: the persistence of congenital syphilis in Brazil - More progress needed! ( 27521453 )
2016
12
Congenital syphilis in the era of decreasing seroprevalence. ( 26776135 )
2016
13
Diagnosing congenital syphilis using Hutchinson's method: Differentiating between syphilitic, mercurial, and syphilitic-mercurial dental defects. ( 26696588 )
2016
14
Early Postnatal Diagnosis of Congenital Syphilis: Contribution of a Comparative Western Blot Method. ( 26961856 )
2016
15
Eliminating congenital syphilis-lessons learnt in the United Kingdom should inform global strategy. ( 27102071 )
2016
16
A Case Report and Review of Early Symptomatic Congenital Syphilis Clinical Variations. ( 26976805 )
2016
17
Underreporting of Congenital Syphilis as a Cause of Fetal and Infant Deaths in Northeastern Brazil. ( 27941983 )
2016
18
Dental Stigmata of Congenital Syphilis: A Historic Review With Present Day Relevance. ( 26897633 )
2016
19
The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015. ( 26931054 )
2016
20
Maternal and congenital syphilis, underreported and difficult to control. ( 27167649 )
2016
21
Wimberger Sign in Congenital Syphilis. ( 26427966 )
2015
22
31-Week Premature Male with Congenital Syphilis. ( 26689031 )
2015
23
Increase in Incidence of Congenital Syphilis - United States, 2012-2014. ( 26562206 )
2015
24
Canadian Public Health Laboratory Network laboratory guidelines for congenital syphilis and syphilis screening in pregnant women in Canada. ( 25798162 )
2015
25
Dental stigmata and enamel thickness in a probable case of congenital syphilis from XVI century Croatia. ( 26263543 )
2015
26
A tryst with a dysmorphic parturient with congenital syphilis. ( 25838595 )
2015
27
Symptomatic Early Congenital Syphilis: ACommon but Forgotten Disease. ( 26522203 )
2015
28
Congenital Syphilis: Trends in Mortality and Morbidity in the United States, 1999-2013. ( 26470826 )
2015
29
Maternal and congenital syphilis in selected Latin America and Caribbean countries: a multi-country analysis using data from the Perinatal Information System. ( 25725563 )
2015
30
Recent change in congenital syphilis in Korea: A retrospective study of 10a88years. ( 25916174 )
2015
31
A review of the guidelines for the evaluation and treatment of congenital syphilis. ( 25996197 )
2015
32
Notification and management of congenital syphilis in the Northern Territory 2009 to 2014. ( 26620345 )
2015
33
Over reporting of congenital syphilis in Guangzhou, China. ( 25587890 )
2015
34
Congenital syphilis presenting as Jarisch-Herxheimer reaction at birth. ( 25868945 )
2015
35
Recurrent Fever, Anemia, Arthralgia, and Genu Varum as Late Manifestations of Congenital Syphilis. ( 26587855 )
2015
36
Congenital syphilis: Marching toward elimination. ( 26392646 )
2015
37
A probable case of congenital syphilis from pre-Columbian Austria. ( 26482430 )
2015
38
Prenatal diagnosis of congenital syphilis presenting with transient pleural effusion in the fetus: a case report and rising incidence of congenital syphilis in South Korea. ( 26753496 )
2015
39
Republication: Two Premature Neonates of Congenital Syphilis with Severe Clinical Manifestations. ( 26543391 )
2015
40
Syphilis in pregnancy and congenital syphilis in Amazonas State, Brazil: an evaluation using database linkage. ( 24896047 )
2014
41
Finding a needle in the haystack: the costs and cost-effectiveness of syphilis diagnosis and treatment during pregnancy to prevent congenital syphilis in Kalomo District of Zambia. ( 25478877 )
2014
42
Early detection of congenital syphilis. ( 25231043 )
2014
43
Incidence of congenital syphilis in the South Region of Brazil. ( 24861290 )
2014
44
Coexistence of congenital syphilis and cytomegalovirus infection: a case report. ( 25230065 )
2014
45
Risk factors for congenital syphilis and adverse pregnancy outcomes in offspring of women with syphilis in Shenzhen, China: a prospective nested case-control study. ( 24326577 )
2014
46
Maternal and congenital syphilis in Karnataka, India. ( 24968685 )
2014
47
50 years ago in the journal of pediatrics: congenital syphilis: a laid ghost walks. ( 24359901 )
2014
48
Evaluation of preventative and control measures for congenital syphilis in State of Mato Grosso. ( 25075485 )
2014
49
Synthesized prevention and control of one decade for mother-to-child transmission of syphilis and determinants associated with congenital syphilis and adverse pregnancy outcomes in Shenzhen, South China. ( 24973132 )
2014
50
Congenital syphilis investigation processes and timing in Louisiana. ( 25118972 )
2014

Variations for Congenital Syphilis

Expression for Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for Congenital Syphilis

Pathways related to Congenital Syphilis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Congenital Syphilis

Biological processes related to Congenital Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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