MCID: CNG021
MIFTS: 48

Congenital Toxoplasmosis malady

Fetal, Neuronal, Infectious categories

Summaries for Congenital Toxoplasmosis

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. spontaneous abortion and stillbirth may occur.

MalaCards: Congenital Toxoplasmosis, also known as toxoplasma embryofetopathy, is related to toxoplasmosis and rubella, and has symptoms including seizures/epilepsy/absences/spasms/status epilepticus, intellectual deficit/mental/psychomotor retardation/learning disability and failure to thrive/difficulties for feeding in infancy/growth delay. An important gene associated with Congenital Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways is Primary immunodeficiency. The compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and whole blood, and related mouse phenotype nervous system.

Aliases & Classifications for Congenital Toxoplasmosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal, Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
congenital toxoplasmosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

congenital toxoplasmosis 8 43 10 49
toxoplasma embryofetopathy 49
toxoplasmosis, congenital 61
toxoplasmosis congenital 45
toxoplasmosis - congen. 8
toxoplasma embryopathy 49


External Ids:

Disease Ontology8 DOID:13336
MeSH35 D014125
NCIt40 C50503
MESH via Orphanet36 D014125
ICD10 via Orphanet26 P37.1
SNOMED-CT via Orphanet58 73893000
UMLS via Orphanet62 C0040560
ICD1025 P37.1

Related Diseases for Congenital Toxoplasmosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Congenital Toxoplasmosis family:

toxoplasmosis

Diseases related to Congenital Toxoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1toxoplasmosis32.0CD79A, CD40LG
2rubella30.0CD79A, CD40LG
3ocular toxoplasmosis10.5
4congenital human immunodeficiency virus10.4
5diabetes insipidus10.3
6congenital cytomegalovirus10.3
7cytomegalovirus infection10.3
8congenital central diabetes insipidus10.3
9cataract, congenital10.2
10myelitis10.2
11biliary atresia10.0
12sensorineural hearing loss10.0
13lymphocytic choriomeningitis10.0
14west syndrome10.0
15retinitis pigmentosa10.0
16hereditary elliptocytosis10.0
17microcephaly10.0
18acquired immunodeficiency syndrome10.0
19eosinophilic meningitis10.0
20toxocariasis10.0
21n syndrome10.0
22cholelithiasis10.0
23strabismus10.0
24congenital rubella10.0
25hydrops fetalis10.0
26precocious puberty10.0
27lymphedema, congenital10.0
28cd40 ligand deficiency10.0CD40LG
29cryptosporidiosis10.0CD79A
30meningoencephalitis10.0CD79A
31syphilis10.0CD79A
32celiac disease10.0CD79A
33meningitis10.0CD79A
34dermatitis herpetiformis10.0CD79A
35pemphigus foliaceus10.0CD79A
36q fever10.0CD79A
37brucellosis10.0CD79A
38guillain-barre syndrome10.0CD40LG
39mumps10.0CD79A
40leptospirosis10.0CD40LG
41pyelonephritis10.0CD79A
42immunoglobulin g deficiency10.0CD79A, CD40LG
43macroglobulinemia10.0CD79A
44selective iga deficiency disease10.0CD40LG, CD79A
45dermatitis10.0CD79A
46immunodeficiency, centromere instability and facial anomalies syndrome10.0CD79A, CD40LG
47immunoglobulin alpha deficiency10.0CD79A, CD40LG
48immunodeficiency with hyper igm type 110.0CD79A, CD40LG
49infectious mononucleosis10.0CD79A, CD40LG
50connective tissue disease10.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Congenital Toxoplasmosis:



Diseases related to congenital toxoplasmosis

Clinical Features for Congenital Toxoplasmosis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 27)
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • nystagmus
  • intracranial/cerebral calcifications
  • hydrocephaly
  • hypotonia
  • hearing loss/hypoacusia/deafness
  • hepatomegaly/liver enlargement (excluding storage disease)
  • mild visual loss/impaired visual acuity
  • retinitis pigmentosa/retinal pigmentary changes
  • microcephaly
  • visual loss/blindness/amblyopia
  • cardiomegaly
  • ascitis
  • hepatitis/icterus/cholestasis
  • anaemia
  • macules
  • thrombocytopenia/thrombopenia
  • dilated cerebral ventricles without hydrocephaly
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • intrauterine growth retardation
  • abnormal hepatic enzymes/transaminases
  • prematurity
  • lymphadenopathy/polyadenopathies
  • acute diarrhea
  • antenatal exposure : toxoplasmosis

Drugs & Therapeutics for Congenital Toxoplasmosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Congenital Toxoplasmosis

Drug clinical trials:

Search ClinicalTrials for Congenital Toxoplasmosis

Search NIH Clinical Center for Congenital Toxoplasmosis

Search CenterWatch for Congenital Toxoplasmosis

Genetic Tests for Congenital Toxoplasmosis

Anatomical Context for Congenital Toxoplasmosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Congenital Toxoplasmosis:

33
Spinal cord, Brain, Whole blood, Placenta, Monocytes, T cells, B cells, Fetal brain, Pituitary

Animal Models for Congenital Toxoplasmosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Congenital Toxoplasmosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.6ABCA4, CD79A, CD40LG, NLRP1, COL2A1

Publications for Congenital Toxoplasmosis

Sources:
51PubMed
See all sources

Articles related to Congenital Toxoplasmosis:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Toxoplasma gondii infection in Kyrgyzstan: seroprevalence, risk factor analysis, and estimate of congenital and AIDS-related toxoplasmosis. (23409201)
2013
2
Congenital toxoplasmosis. (23622316)
2013
3
A dedicated surveillance network for congenital toxoplasmosis in Greece, 2006-2009: assessment of the results. (23173875)
2012
4
Congenital toxoplasmosis: evaluation of molecular and serological methods for achieving economic and early diagnosis among Egyptian preterm infants. (20961951)
2011
5
First Colombian multicentric newborn screening for congenital toxoplasmosis. (21655304)
2011
6
Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review. (20582922)
2010
7
Sensorial strabismus due to congenital toxoplasmosis. Is it an eso- or exotropia? (20923407)
2010
8
IgG and IgM western blot assay for diagnosis of congenital toxoplasmosis. (20944989)
2010
9
Cerebral and ocular congenital toxoplasmosis complicated by West syndrome. (20714363)
2010
10
Placental testing for Toxoplasma gondii is not useful to diagnose congenital toxoplasmosis. (20305580)
2010
11
Toxoplasma gondii antibody profile in HIV-infected pregnant women and the risk of congenital toxoplasmosis. (18855029)
2009
12
Congenital toxoplasmosis in southeastern Brazil: results of early ophthalmologic examination of a large cohort of neonates. (19744724)
2009
13
Azithromycin reduces ocular infection during congenital transmission of toxoplasmosis in the Calomys callosus model. (20050006)
2009
14
Hearing loss in congenital toxoplasmosis detected by newborn screening. (18392497)
2008
15
Longitudinal study of new eye lesions in treated congenital toxoplasmosis. (17825418)
2008
16
Disease burden of congenital toxoplasmosis. (17479945)
2007
17
Retinitis pigmentosa and congenital toxoplasmosis: a rare coexistence. (17595483)
2007
18
Cellular and molecular physiopathology of congenital toxoplasmosis: the dual role of IFN-gamma. (17958925)
2007
19
Risk factors for congenital toxoplasmosis are not always obvious. (16522442)
2006
20
Ophthalmic outcomes after prenatal and postnatal treatment of congenital toxoplasmosis. (12788116)
2003
21
Congenital toxoplasmosis: assessment of risk to newborns in confirmed and uncertain maternal infection. (12856175)
2003
22
Congenital toxoplasmosis in the United Kingdom: to screen or not to screen? (12370327)
2002
23
Impact of health education on knowledge and prevention behavior for congenital toxoplasmosis: the experience in PoznaA8, Poland. (11525395)
2001
24
High prevalence of congenital toxoplasmosis in Brazil estimated in a 3-year prospective neonatal screening study. (11034982)
2000
25
Commentary: Congenital toxoplasmosis--further thought for food. (10950535)
2000
26
The role of IL-4 in adult acquired and congenital toxoplasmosis. (9504339)
1998
27
Congenital toxoplasmosis: diagnosis by exfoliative cytology. (9582573)
1998
28
Central diabetes insipitus in a patient with congenital toxoplasmosis. (9572376)
1998
29
Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent. (9802080)
1997
30
Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection. (9200383)
1997
31
Ascending paralysis due to myelitis in a newborn with congenital toxoplasmosis. (8836988)
1996
32
Congenital toxoplasmosis: prevention, screening and treatment. (7560949)
1995
33
Evaluation of strategies to reduce the risk of congenital toxoplasmosis: a decision tree analysis approach. (7804220)
1994
34
Congenital toxoplasmosis. The Toxoplasmosis Study Group. (9422215)
1994
35
Congenital toxoplasmosis presenting with eosinophilic meningitis. (8483631)
1993
36
Possible reasons for failure of conventional tests for diagnosis of fatal congenital toxoplasmosis: report of a case diagnosed by PCR and immunoblot. (1644491)
1992
37
Screening programme for congenital toxoplasmosis in France. (1290073)
1992
38
An outbreak of congenital toxoplasmosis in northern Quebec. (1365154)
1991
39
Difficulties in the diagnosis of congenital toxoplasmosis by cordocentesis. Case report. (1911595)
1991
40
Congenital toxoplasmosis. The Toxoplasmosis Study Group. (2189295)
1990
41
An electron microscope and immunohistochemical study of the intracellular location of Toxoplasma tissue cysts within the brains of mice with congenital toxoplasmosis. (2504268)
1989
42
Congenital toxoplasmosis presenting as isolated acute chorioretinitis in the neonate. (3343638)
1988
43
Congenital acquired immunodeficiency syndrome and congenital toxoplasmosis: pathologic support for a chronology of events. (3236102)
1988
44
Congenital toxoplasmosis: epidemiologic features and control. (3756692)
1986
45
Results of 20-year follow-up of congenital toxoplasmosis. (2868264)
1986
46
Congenital ocular toxoplasmosis. (6827609)
1983
47
In vitro lymphocyte stimulation with specific antigen in congenital toxoplasmosis. (7031854)
1981
48
Congenital toxoplasmosis. (7033920)
1981
49
Infants potentially at risk for congenital toxoplasmosis: a prospective study. (7395824)
1980
50
Congenital ocular toxoplasmosis. (14929406)
1952

Genetic Variations for Congenital Toxoplasmosis

Expression for genes affiliated with Congenital Toxoplasmosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congenital Toxoplasmosis

Search GEO for disease gene expression data for Congenital Toxoplasmosis.

Pathways for genes affiliated with Congenital Toxoplasmosis

Sources:
30KEGG
See all sources

Pathways related to Congenital Toxoplasmosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD79A, CD40LG

Compounds for genes affiliated with Congenital Toxoplasmosis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Congenital Toxoplasmosis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4510.0CD79A, CD40LG
2sandoglobulin4510.0CD79A, CD40LG
3gamma globulin4510.0CD79A, CD40LG
4vancomycin45 1111.0CD79A, CD40LG
5pneumococcal4510.0CD40LG, CD79A
6blys4510.0CD79A, CD40LG
7tuberculin4510.0CD79A, CD40LG
8praziquantel45 1111.0CD79A, CD40LG
9hemocyanin4510.0CD40LG, CD79A
10gliadin4510.0CD79A, CD40LG
11pmma4510.0CD79A, CD40LG
12silicone4510.0CD79A, CD40LG
13mannan459.9CD79A, CD40LG
14okt3459.9CD79A, CD40LG
15glutaraldehyde459.9CD40LG, CD79A
16sulfasalazine45 29 50 1112.9CD79A, CD40LG
17cardiolipin45 1110.9CD79A, CD40LG
18mycophenolate mofetil45 50 1111.9CD40LG, CD79A
19valproate459.9CD79A, CD40LG
20phenytoin45 50 29 1112.9CD79A, CD40LG
21cytidine45 11 2411.8CD79A, CD40LG
22anti-fungal459.8CD40LG, CD79A
23ivig459.8CD79A, CD40LG
24doxycycline45 1110.8CD79A, CD40LG
25vitamin b12459.7CD79A, CD40LG
26alginate459.7CD79A, COL2A1
27neopterin459.7CD40LG, CD79A
28rituximab45 50 1111.6CD79A, CD40LG
29polyethylene glycol459.6CD79A, CD40LG
30allergens459.5CD79A, CD40LG
31ascorbic acid45 2410.3COL2A1, CD40LG, CD79A
32theophylline45 29 11 2412.3CD79A, CD40LG

GO Terms for genes affiliated with Congenital Toxoplasmosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Congenital Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.6CD79A, CD40LG
2B cell proliferationGO:0421009.3CD79A, CD40LG

Products for genes affiliated with Congenital Toxoplasmosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congenital Toxoplasmosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet